BME 722/822 / ECE 895 – Quantitative Analysis of Human Physiological Systems II

Class time: Tuesday/Thursday 11.00-12.15h, KH228

Instructor: Dr. Christian ZemlinOffice: IRP-2 (Monarch Way 4211), Rm 418Email: czemlin@odu.edu

Use an email subject line: QAHPS2 + a descriptive subjectOffice hours: F 2.00-3.00 pm or by appointment

Textbook: Mathematical Physiology II by James Keener and James Sneyd, 2nd Edition. Springer, NewYork (2008). Note: Only part of the course is covered by the textbook, and buying it is not obligatory.

Pre-, Co-requisites: BME 721/821 / (Quantitative Analysis of Human Physiological Systems I)

Course Web site: BlackBoard will be used in this course for the purposes of communication, posting grades and providing certain additional course materials. You should be sure to check BlackBoard regularly to ensure you receive any critical announcements that may be posted over the course of the semester. To access BlackBoard at www.blackboard.odu.edu you must have a valid ODU e-mail account.

Topics to be covered1. The endocrine system2. Muscle3. Renal physiology4. Vision5. Respiration 6. The heart

Learning outcomes: 1. The ability to formulate, implement, and analyze mathematical models of spatially distributed

physiological systems.2. An understanding in which situations distributed systems can be adequately described by ordinary

differential equations and in which situations partial differential equations are necessary3. The ability to numerically solve 1D and 2D partial differential equations and to visualize the

results.4. Experience in modeling major body systems, including the endocrine system, muscle, the kidneys,

vison, respiration, and the heart.5. Formulate and execute a larger modeling project (six weeks).6. Present the results of the modeling projects.

Lecture schedule

Date Day Topic Assignments 1 1/14 Tu Introduction, Muscle: The Hill model2 1/16 Th Muscle: The Huxley crossbridge model Hill/Huxley models3 1/21 Tu Vision: Ligth adaptation4 1/23 Th Vision: Receptor physiology Receptor physiology I5 1/28 Tu Vision: Receptor physiology6 1/30 Th Vision: Receptor physiology / in-class

programmingReceptor physiology II

7 2/4 Tu Endocrine system: Insulin and glucose8 2/6 Th Endocrine system: Insulin and glucose Insulin and glucose9 2/11 Tu Kidney : Glomerulus10 2/13 Th Kidney: Urinary concentration Urinary concentration11 2/18 Tu Respiration: Gas exchange12 2/20 Th Respiration: Regulation of ventilation Respiration13 2/25 Tu Midterm14 2/27 Th Heart: Propagation in 2D Spiral waves15 3/4 Tu Heart: Spiral waves16 3/6 Th Heart: ECG I17 3/18 Tu Discuss midterm / assign projects Projects: Week 118 3/20 Th Heart: ECG II19 3/25 Tu Phenomenological models of excitation Projects: Week 220 3/27 Th 3D: Scroll waves21 4/1 Tu 3D: Scroll waves Projects: Week 322 4/3 Th Realistic geometries: Finite Difference and

Elements23 4/8 Tu Realistic geometries: Finite Difference and

ElementsProjects: Week 4

24 4/10 Th Ovulation in mammals25 4/15 Tu Ovulation in mammals Projects: Week 526 4/17 Th Project advising27 4/22 Tu Project advising Projects: Week 628 4/24 Th Presentation preparation29 4/29 Tu Presentation of modeling projects

Grading and homeworksThere will be six graded homeworks; each of them will be given on a Thursday and is due the following Wednesday by noon. Each homework counts 3% towards the final grade. The Midterm Exam counts 20% and the Final Exam 32%. In the last six weeks, the homework will consist of modeling projects that the students work on individually or in small groups. The final presentation of the modeling projects counts 30% towards the grade.

Grade composition:Homeworks: 18%Midterm: 20%Final Exam: 32%Presentation of modeling project: 30%

Special accommodationsIf you require special accommodations, contact me at the earliest possible time so that alternate arrangements can be made for taking exams and completing assignments. The Office of Educational Accessibility is located in 1525 Webb Center and can be contacted at (757) 683-4655. Information can also be found at http://studentaffairs.odu.edu/educationalaccessibility/

Academic integrityAcademic dishonesty of any kind will not be tolerated. You are expected to adhere to all aspects of the ODU Honor System. The Honor Code, Honor Pledge, and the Monarch Creed can be found at http://studentaffairs.odu.edu/oscai/. Appeal procedures can be found at http://www.odu.edu/ao/bov/manual/pdfs/1530.pdf