ebuilding A Brain

Dr. Marc Funderlich Jr.

Rebuilding A Brain

Objectives

1. Neurology

2. HBOT

3. Laser

4. Immunology

Why

Why

Why

Why

Why

Principles in Our Practice

Metabolic Stability

Energy Optimization,

Oxygen / Electrons

Neuro-Specific

Activation

Functional Neurology

Eye Movements

Vestibular

Holds image of the seen

world steady on the retina during brief

head rotation or translation

Holds image of the stationary object on he

fovea by minimizing drift

Holds image of the seen world steady on the retina during

sustained head rotation

Visual Fixation

Optokinetic Smooth Pursuit

Nystagmus Quick Phase

Saccades Vergence

Holds the image of a

moving target on the fovea either with

head or object motion.

Resets the eyes during

prolonged rotation and direct gaze

towards the oncoming visual

stimulus

Brings images of objects of interest onto

the fovea

Moves the eyes in opposite directions

When They break you can experience the same symptoms

Future

Future

Future

Future

Future

Future

Functional Neurology

Future

Future

Future

• How do we implement HBOT and laser with neuro rehab?

• Before after during?

• How Long?

HBOT

HBOT

HBOT

HBOT

Neuroimmune Approach To Brian Health

What Made Einstein Different?








The accumulation of macrophage-like cells was semiquantitatively assessed

by CD68 staining in the ischaemic area and ischaemic border zone, and linked

to the clinical course. CD11b, ionized calcium binding adaptor molecule 1

(Iba), glial fibrillary acidic protein (GFAP) and Neuronal Nuclei (NeuN) were

applied to reveal delayed glial and neuronal alterations. In all groups, the

accumulation of macrophage-like cells increased distinctly from 24 hours to 7

days post ischemia.

The tendency towards a decreasing macrophage-like cell

accumulation after tPA+HBO needs to be discussed

critically since neuroprotective properties were recently

ascribed to long-term inflammatory processes.


Is Hyperbaric Alone Enough?


Broken or Intact BBB

Transport Signaling


CBC

Inflammation

CMP

Vit D

ThyroidAutoimmune

Iron

Blood Sugar

Hormones



Polyphenols only become active via

microbiome enzymes

Polyphenols can not cross an unhealthy BBB



ORAL FLUID COLLECTION

WHY TEST MUCOSAL

IGA IN CHILDREN

• Systemic Immune Failures normally caught by the

medical system

• Starting place for interaction with Environment

• Information we can act on

S E C R E T O R Y I G A S E C R E T I O N A N D

R E L A T E D E V E N T S

T H R O U G H T H E P R E N A T A L A N D

E A R L Y D E V E L O P M E N T

O F A C H I L D .

S C = S E C R E T O R Y C O M P O N E N T

42



45Triggers of polyreactive antibodies by T-cell-independent mechanism or by B cell

46

Binding of a single antibody to three different epitopes due to the flexibility of the binding sites. Modified from Dimitrov et al. 2013.


48

SUGGESTIONS ON HOW TO FIX ORAL TOLERANCE

Key Nutrients Explored

250mg-1000mg Saccharomyces Boulardii

1 billion-30 billion Lactobacillus GG, Plantarum,

Rhamnosus, Bifido Bifidus (or other IL10 inducing probiotics)

Iron binding Probiotics

- Propionibacterium freudenreichii/ Escherichia coli Nissle 1917

Diet rich in AhR ligand foods and SCFA promoting foods

12,000-50,000iu of Vitamin A (Retinol Palmitate)

2,000-50,000iu Vitamin D3

MitoQ 5-10mg daily (or ubiqinol ≥100mg) BID

Lipid Replacement Therapy – 1000mg-1500mg TID

B12 supplementation

Aloe Vera, Oral 50ml

Key Lifestyle Events Explored

Time restricted feeding (TRF)

Focused exercise

Metabolic integration with mitochondria

Reduced exogenous exposure

Inhibition of inflammasomes

Microbial diversification

Metabolite induction

Barrier management




Time Table

Start Patient Specific Metabolic Stability

Start Veggie Mash or Short Chain Fatty Acid

/ FiberStart Hyperbaric

Introduce Anti-Inflammatory / Brain

Specific

2 weeks prior to HBOT or practitioner

decision

2 weeks prior – 3 days prior

Introduce after 10 hours / 2 weeks

Low Level Laser Combined with HBOT

Energy Optimization

Energy Optimization

Glycolysis

Pyruvate Pyruvate

2 Acetyl CoA

Citric Acid Cycle / KrebCycle

Chain of complex chemical reactions

FADH2 NADHNADPH

Oxidative Phosphorylation

H20ATP

Energy Optimization

Energy Optimization

• Terminal Enzyme of the electron transport chain

• Needed for ATP production

• Large drop in Gibbs free energy

• Low in vivo reserve capacity

• Mediating the electrontransfer from Cytochrome C to molecular oxygen.

Energy Optimization

• Oxidative Stress

• Optimal health is hurt by psychosocial / biologic stress due to

• Over production of reactive oxygen species

• O2- and H2O2 inside the Mitochondria

Superoxide radical anion O2- mostly produced O2- plus

superoxide dismutases

Yield H2O2

Energy Optimization

Healthy Unhealthy

Mitochondria Membrane Mitochondria Membrane

100-130mV 180-200mV

Healthy ATP levels = Healthy Cell Low ATP levels = Cell Headed to Apoptosis

Energy Optimization

Bacterial COX

• 3-4 sub units

Mammalian COX

• 13 sub units not 14

Cytochrome C Oxidase catalyzes electron transport from cytochrome c to oxygen and the pumping of protons

Energy OptimizationC

OX

Reg

ula

tio

n Expression of tissue-

specific / species specific isoforms

Interactions with small molecules like nucleotides

and hormones

Reversible phosphorylation of subunits at serine, threonine or tyrosine

Loose and reversible binding of proteins or

enzymes

Binding to form a super-complex

Major rate limiting step for mitochondrial respiration in vivo

Energy Optimization

Energy Optimization

Biogenesis of COX

20 nuclear-coded

accessory proteins

Hemes a, a3

Copper CuA, CuB

Translational activators

Translocases

Molecular chaperones

Energy Optimization

• COX produces no ROS during reduction of dioxygen

• Heme, Cu, and tyrosyl-group allow 4 electrons to transfer simultaneously to O2

Cytochrome C Oxidase can yield 5-7x more processing power than needed

Cytochrome C Oxidase

Red Visible Light Wave Lengths

Cytochrome C Oxidase (complex 4) acts as a

photoceptor

Increases available electrons for reduction

Increased MMP

Increased ATP, cAMP

Increased short term

ROS


Time Table



/ Fiber

Start Hyperbaric Treatment and LLLT

Introduce Anti-inflammatory / Brain

Specific


decision



Neuro-General Rehab

Neuro-General Rehab

Neuro-General Rehab

Neuro-General Rehab

Neuro-General Rehab

Rebuilding A Brain

Time Table



/ Fiber

Start Hyperbaric Treatment and LLLT

Introduce Anti-inflammatory Therapy

/ Brain Specific


decision



Introduce TcVnsand HIIT

Introduce ½ way through protocol

Disclosures

• No Disclosures to announce

• Special thanks to Dr’s Kharrazian, Vojdani, and Yanuck for their great work and contributions to this lecture

Documents

ebuilding A Brain