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Early Pregnancy Loss
Definition
• Nonviable intrauterine pregnancy charactized by empty gestational sac or embryo/fetus <13 weeks with no fetal heart activity
• 10% of all pregnancies• 50% are generally chromosomal
abnormalities
Signs and Symptoms
• First trimester cramping/bleeding• DDx: early pregnancy loss, viable
intrauterine pregnancy, ectopic pregnancy
• A pelvic exam is important before testing
Testing
• Ultrasound is the prefered method to determine viabilty
• HCG levels are important in interpreting ultrasound findings and for serial follow up
Beta HCG
• Discriminatory zone 1500-2000 mIU/ml is associated with a gestational sac in singleton pregnancies
• A rise of < 50% in 48 hours is associate with an abnormal pregnancy with a sensitivity of 99%
Treatment Options
• Expectant• Medical treatment• Surgical treatment
Expectant
• May take up to 8 weeks• 80% success• What is success
– HCG < 5 mIU/ml– Endometrial stripe of < 3 cm– Return of normal menstrual function
• Patient needs to be prepared for moderate to heavy bleeding with cramps and may need a suction currettage
Medical Treatment
• Goal is to shorten the time to complete explusion as compared to expectant
• 85% success with complete expulsion with in 3 days for 70% of patients
• Patient should expect moderate to heavy bleeding and cramping issues as well as possible suction currettage
Surgical
• Suction curettage has replaced sharp curetting
• It is immediate and 99% successful• Clinically important intrauterine
adhesions are a rare complication
Complications of all treatments
• Incomplete requiring curettage• Infection 2%• Transfusion 1%
Rh Negative Mother
• Give 50-300 micrograms rhogam within 72 hrs of diagnosis of early pregnancy loss
Subsequent Pregnancy
• No evidenced based data on when it is safe to get pregnant again
• BCP or IUD can be started as soon as you are sure the process is complete
• Consider workup for recurrent EPL after the 2nd consecutive EPL
• No proven treatment for threatened abortion
• Progesterone in first trimester after at least 3 EPL may be beneficial
Case Studies
Am I ready to do office gyn?
Sally is a 23 y/o GoPo complaining of irregular bleeding
Gyn Hx: sexually active uses condoms most times
PE: 105 lb
Abdomen soft nontender
Pelvic exam: no vaginal bleeding, Cervix is closed nontender, uterus normal, adenexa neg
Test Results
• Quantative Beta HCG < 1
• Ultrasound normal uterus, endometrium, and ovaries
What if Ultrasound Shows
• uterus 11x9x8 cm with multiple leiomyoma about 2-3 cm in diameter, endometrial thickness 6 mm, normal ovaries
Sally returns after 3 months on her new birth control pill still having breakthrough bleeding
Pelvic exam is normal
Test: STD negative pregnancy test negative
Judy is a 30 y/o G2P2 for annual exam on Ortho Tricyclen Lo
Social hx: married, monogamous
She is complaining that she had regular periods for a while but now having breakthrough bleeding for 6 months
Exam: Normal
Differential diagnosis?
Mary is a 45 y/o G3P3 status post tubal ligation
Menstral formula: 2 weeks/3 days heavy on day 1
PMH: negative
Pelvic exam: Cervix normal, pap doneUterus 6 weeks size, irregular, firm,
nontenderOvaries not enlarged, nontender
Guidelines for Endometrial Biopsy
• All women with history of AUB of 2-3 yrs duration
• All women > 45 yrs old with AUB• All women who do not respond to
treatment
Endometrial Biopsy Results
• Complex hyperplasia with atypia• Complex hyperplasia• Simple hyperplasia• Proliferative endometrium• Secretory endometrium
Vicki is a 60 y/o complaining of 3 days of light bleeding 3 weeks ago
PMH: Illnesses: diabetes controlled on diet
mild hypertension
Meds: Atenolol
Continuous hormone replacement therapy
Exam: 5’4”, 175 lb
Pelvic:vagina slightly atrophic
cervix stenotic, pap done
uterus NS/NS
adenexa negative
Endometrial thickness
• < 4 mm generally atrophic endometrium
• > 4 mm you can’t rule out cancer
60 yr old menopausal female complaining of incontinence
PI: leaking urine for several months now worse
PMH: TAH/BSO for benign disease age 45
Lumbar disk fusion 1 years ago
PE: Pelvic – 1st degree cystocoele and 1st degree rectocoele
• Complaining of urgency, frequency, nocturia, sudden loss of large amounts of urine
• Residual urine 10 ml
• Urine culture positive > 100,000 e-coli
• Loss of urine with coughing, sneezing, laughing, squatting, jumping
• Residual 50 ml and culture negative
• Residual > 200 ml
22 yr old female complaining of amenorrhea for 1 yr
PI: LMP 1 yr ago prior menstral formula 28d/5d
BC: noneGyn Hx delivered a baby 2 yrs ago
PMH: Schizophrenic on anti-psychotic med
Soc Hx: Occasionally sexually active without condoms
PE: Thin female, no distressBreasts bilateral milky dischargePelvic exam normal
• Prolactin 100 ng/ml., TSH 5.5 uU/ml.,
• Prolactin, TSH normal