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Corticosteroids:

Advantage:

• gluconeogenesis => increase cell growth and less feeling of cold in winter

Disadvantage:

• Abortion from 6th month of pregnancy

Mode of Action:

Inected !> enter into body cells => attached to steroid receptors in cytoplasm =>

enter into nucleus !>protein synthesis and en"yme control => inhibits the

phospholipase a!# en"yme which is directly proportional to arachidonic acid $##

carbons% in&ammatory mediator' => (o in&ammation => anti!in&ammatory )

analgesic ) antipyretic

Indications:

• *aminitis

• Musculos+eletal disorders

• Allergic reactions

•  ,o-emia

• .hoc+

.ide e/ects:

• Abortion => prostaglandin production => regress corpus lutiam =>

abortion

• Immunosuppression => inhibits the antibody formation => decreased

concentration of lymphocytes and eosinophils $, and 0 cells'

• Delayed wound healing => decreased migration of neutrophils at inured

site => decreased phagocytosis

1ole of administration:

I23% I2M% intra!articular

.alts:

45 rednisolone acetate#5 rednisolone acetate ) De-amethasone75 Iso&uprednisolone acetate85 De-amethasone

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rednisolone acetate:

• Intermediate acting corticosteroid

• 4#!76 hrs

• 9uines ;

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• *ong acting caricosteroids

• 8F hrs to B# hrs

• 1uminants ;