"Metformin (Glucophage)"-It increases peripheral glucose uptake
& decreases both basal & postmeal BG-Take it w/
food-mointor LL & KK- LACTIC ACIDOSIS -adverse reaction-hold
24-48 hrs before & after ivy dye
2) Sulfonylurea agents --> inhibit K+ channels in BETA CELLS
which increases insulin release (3 main drugs)
"Glipizide (Glucotrol)"-take 30 min before meals-KK
function-Adverse effects --> HYPOGLYCEMIA, disulfram like
effects (GI disturbances)-Avoid NSAIDs (pg 1428 -- all the meds
that interact w/ Sulgonylurea agents)
"Micronase (Glyburide)"
5) Miglitinide Analogs --> similar action & adverse
effect to Sulfonylureas.
"Nateglinide (Starlix)"
-rapidly absorbed & stimulates insulin secretion within 20
min
-taken just before meals to control mealtime hyperglycemia &
improves overall glycemic control
-adverse effect -- HYPOGLYCEMIA
-if skipping meal, also skip dose to reduce risk of
hypoglycemiaIncretin Memetics (GLP-1 agonist) Exenatide (Byetta)
-increases insulin secretion by increasing CAMP levels within the
cell-decreases glucagon release -Adverse effects PANCREATITIS, GI
disturbances
