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Drug Formulation / Drug Delivery
Raj Suryanarayanan (Sury)Department of Pharmaceutics
College of [email protected]
1
Faculty Research AreasBiological Pharmaceutics
(Pharmacokinetics, Pharmacodynamics, Metabolism)
Elmquist, Fairbanks, Sawchuk, Zimmerman
Physical Pharmaceutics (Materials Science)
Suryanarayanan, Sun
Drug Delivery
Kandimalla, Prabha, Panyam, Siegel, Wiedmann
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Center for Translational Drug Delivery
Developing collaborative relationships with pharmaceutical companies in the
area of drug delivery
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Raj Suryanarayanan(Sury), [email protected]
Goals and missions of the CenterBring together faculty with interest in drug
deliveryLeverage our comprehensive expertise in
drug delivery – develop collaborations with pharmaceutical companies
Work with the different administrative units to expedite legal and contractual issues
Serve as a platform for training grants and program project grants that are focused on drug delivery
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AeroCore
Supporting research and product development through inhalation
drug delivery
Core Activities
Aerosol generation Characterization of aerosol particles (output/particle
size distributions) Exposure of rodents to aerosol particles or vapors Measurement of chemicals deposited in the
respiratory tract and accumulation in blood of rodents Gross and microscopic examinations of rodents Disease induction in animal models (e.g. cancer)
1. Drug solubilization through engineering solid form (nanocaging, solid dispersion, cocrystallization, salt formation, etc.)
2. Tablet formulation and manufacturing process understanding and control
3. Structure-mechanical property relationship in organic crystals and powders
The aqueous solubility of poorly soluble drugs is significantly improved by nanocaging.
C.C. Sun
Kandimalla lab drug delivery projects
Design of nanotheranostics for the diagnosis and treatment of cerebrovascular diseases.
Elucidation of biophysical properties of endogenous macromolecules and their transport across the cellular barriers, particularly the blood brain barrier.
Development of novel drug delivery approaches to disrupt bacterial biofilms.
Strategies to evaluate and enhance oxidative stability of natural carrier oils.
Prabha Research Interests
Oral formulations to improve bioavailability of Oral formulations to improve bioavailability of poorly soluble drugspoorly soluble drugs
Anti-angiogenic therapy for ovarian cancerAnti-angiogenic therapy for ovarian cancer
Photodynamic therapy for treating microbial Photodynamic therapy for treating microbial infections in chronic woundsinfections in chronic wounds
Sustained protein/gene delivery for chronic woundsSustained protein/gene delivery for chronic wounds
Panyam Research Interests
Targeted Antibiotic Delivery for Chlamydial InfectionsTargeted Antibiotic Delivery for Chlamydial InfectionsNIAID/NIH NIAID/NIH
Magnetic Hyperthermia for Lung CancerMagnetic Hyperthermia for Lung CancerDepartment of Defense Department of Defense
Targeting Cancer Stem CellsTargeting Cancer Stem CellsRandy Shaver Foundation Randy Shaver Foundation
Polymeric Systems for Cancer Prevention/TreatmentPolymeric Systems for Cancer Prevention/TreatmentNCI/NIHNCI/NIH
SIEGEL LAB• Polymeric Drug Delivery Systems, Hydrogels• Microfabricated Sensors (e.g. temperature, pH,
glucose)• Intranasal Delivery of Low Solubility, Fast Acting
Drugs
Unabsorbed DZP Cleared in Nasopharynx
Diazepam (DZP) prodrug administered with converting enzyme
Absorption Through
Nasal MucosaDZP in
Bloodstream
Crystallization in
Nasal Cavity
Starting Line Finish Line
“Crystallization” Horse “Absorption” Horse
Application:Canine Epilepsy