DR.R.MEHER ALI, M.D.PROFESSOR OF

CLINICAL PHARMACOLOGY

MADRAS MEDICAL COLLEGE

CHENNAI.

IMPORTANCE OF PLANTS & THEIR PRODUCTS

• Plants – Major source of drugs

Eg :

Digoxin

Vincristine

Vinblastine

Atropine

DRUG DISCOVERY IDENTIFICATION OF NEW DRUGS

RATIONAL DRUG DESIGN

CHEMICAL MODIFICATION OF KNOWN COMPOUND

BIO TECHNOLOGY

RANDOM SCREENING

ENVIRONMENTAL PHARMACOLOGY

ROLE OF NONI IN ENVIRONMENTAL

PHARMACOLOGY - HIGH SCOPE FOR

FUTURE RESEARCH

ROLE OF NONI IN HEALTH CARE SYSTEM

NONI PLANT ORGAN

COMPOUNDS EFFECTS

Fruit and Fruit Juice Alkaloids

(Xeronine)

Enhances enzyme activity & protein

structure

Foliage & Cell suspensions

1.Anthroquinone

(Damnacanthal)

2.Glycosides

Antiseptic & Antibacterial in GI

Anticancer Effect&

Anti oxidant Effect

Roots 1.Anthroquinones

2. Morindin &

Morindone

Anticancer Effect

Antibacterial Effect

METHODS TO PROVE THE CLAIM • PROPER STANDARDIZATION

UV SPECTROSCOPY

FLUORIMETRY

NMR

IR

MASS SPECTROMETRY

CHROMATOGRAPHY – HPLC, LCMS & GCMS

FUTURE PLANS

• CONTAINS > 150 CONSTITUTIENTS

• YET TO PROVED EXPERIMENTALLY AND CLINICALLY

• PROPER STANDARDIZATION