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HEALTH NUTRITION MATERIALS
ROYAL DSM
Driving sustainable growth through innovationRob van Leen, Chief Innovation Officer & Member Executive CommitteeDelft, September 25, 2017
Safe harbor statement
▪ This presentation may contain forward-looking statements with respect to DSM’s future (financial) performance and
position. Such statements are based on current expectations, estimates and projections of DSM and information
currently available to the company. DSM cautions readers that such statements involve certain risks and uncertainties
that are difficult to predict and therefore it should be understood that many factors can cause actual performance and
position to differ materially from these statements. DSM has no obligation to update the statements contained in this
presentation, unless required by law.
▪ A more comprehensive discussion of the risk factors affecting DSM’s business can be found in the company’s latest
Annual Report, which can be found on the company's corporate website, www.dsm.com
Agenda | Sustainable growth through innovation
Page 1
▪ Innovation within DSM
▪ Big need and potential for biotechnology in the world
▪ DSM is a biotechnology powerhouse
▪ How biotechnology innovation is driving DSM’s above market
1
2
3
4
DSM transformed into an intrinsically innovative company
Page 2
22% (2016)
Innovation Sales
All @ Higher Gross Margins
Top Quartile
Innovation
Benchmark
New Materials & Biotechnology/Food Lab
€426 million R&D investment in 2016
DSM organized for new growth platforms & accelerating innovation
Page 3
BiomedicalBio-based Products
& Services
Advanced Solar Business incubator
Excellence in Innovation Venturing
IP & Licensing Science & Technology
DSM Innovation Center
New Business Development Enablers / Accelerators
We drive innovation through all our businesses
Page 4
Resins & Functional Materials Engineering Plastics
Nutritional Products
Dyneema
Food Specialties
Powered by DSM’s scientific competences
Page 5
Page 6
Biotechnology is a key competence
Delft: DSM’s center of biotechnology
What is biotechnology?
Page 7
Living micro-
organismse.g. dairy cultures
for cheese ripening
Cell extractse.g. yeast extracts
for savory flavor
Purified products e.g. enzymes for
bread structuring
Industrial Micro-Organisms
Renewable Feedstock
Bacteria Yeasts
Fungi
+
Algae
DSM’s biotechnology strength has a long history since 1870
Page 8
▪ Biorefinery
▪ Bioinformatics and modeling
▪ Systems & synthetic biology
▪ Automated Strain Engineering
▪ Whole genome sequencing
▪ Low-cost DNA synthesis
▪ Precision Genome Editing
▪ Recombinant DNA technology
▪ Biocatalysis
▪ Metabolic pathway engineering
▪ Advanced analysis
▪ DNA shuffling, DNA sequencing
▪ Protein engineering
▪ Classical strain improvement
▪ Industrial fermentation
▪ Biodiversity exploration
▪ Mutagenesis and screening
▪ Microbial breeding
▪ Exploration natural products
Yeast • Ethanol • Vitamins • Antibiotics • Citric acid • Savory ingredients • Carotenoids
Natamycin • Dairy cultures • Enzymes • PUFAs – Omega’s • Microbial gums • Succinic acid • C5 yeast • Stevia1870 Today
CLASSICAL BIOTECH
(1870 - present)
MODERN BIOTECH
(1980 - present)
INDUSTRIAL BIOTECH
(2005 - present)
DSM’s global biotechnology R&D infrastructure
Page 9
Winchester, KY (US)
- Scale-up and piloting
Lexington, MA (US)
• Carotenoids, flavors &
fragrances, water and fat
soluble vitamins
• R&D with yeast, bacteria,
filamentous fungi
Delft (NL), Shanghai (CN)
• Yeast extracts (flavors),
enzymes, cultures, specialty
ingredients (preservatives,
sweeteners, protein,
biocatalysts,..)
• R&D, scale-up and piloting
• Yeast, bacteria, filamentous
fungi
Columbia, MD (US)
• Nutritional lipids
• Algae, yeast, bacteria,
filamentous fungi
Grenzach (DE)
• Scale-up and piloting
• Formulation
(lab and pilot scale)
Winchester, KY (US)
• Scale-up and piloting
Complemented by partnerships and open innovation enabling further
access to global capabilities and technologies
Page 10
Collaborating with 80+ top academic institutes Active in 30+ Public Private Partnerships (PPPs)
Venturing, partnerships and collaborative innovation initiatives in biotechnology
▪ Continuous technology scouting
▪ Long-standing connecting bright innovations
partnering events attracting start-up in biotechnology
Biotechnology key to address grand challenges of growing global population
Page 11
ChemistryExtraction from
Naturals
Biotechnology
Biotechnology solution of choice:
▪ More sustainable
✓ Clean label
✓ Drive for Natural
✓ Non-fossil based
▪ Lower cost
Biotechnology solution of choice:
▪ More sustainable
✓ Scarcity resources e.g. land/water-use
✓ No chemical extraction
▪ Consistent quality
▪ Lower cost
Biotechnology potential is enormous and growing high-single digit per year
Page 12
North America Europe Asia RoW
Current global market ~US$300-350bnEstimated to grow high-single digit ~US$750bn by 2025*
* Market size and growth based on various publications incl. Deloitte, E&Y, grandviewresearch
Main applications
Medicine - Pharma Chemicals - Fuel
Food Feed Agri
Materials
Innovation Center
DSM has a strong biotechnology driven portfolio
Page 13
Food Specialties Nutritional Products Bio-based Solutions
▪ Food enzymes
▪ Dairy Cultures
▪ Savory yeast-
extracts
▪ Bio-preservatives
▪ Processing agents
▪ Hydrocolloids
▪ Steviol Glycosides
▪ Vitamins
▪ Nutritional Lipids
▪ Natural beta-
carotene
▪ Probiotics
▪ Feed enzymes
▪ Aquaculture,
Green Ocean JV
▪ Ethanol C5 yeast
▪ Cellulosic
enzymes/POET JV
▪ Bio-succinic acid
▪ Proteins - Canola
▪ BioAlliance
▪ Venturing incl.
Isobionics, Amyris
Gistex®, yeast-extract
for taste enhancementOmega-3 and Omega-6
for Early Life Nutrition
Bio-succinic acid for
green materialsInnovative flavor &
fragrance ingredients
CleanCow
Rich biotechnology innovation pipeline driving growth
Page 14
BioAlliance
Steviol Glycosides GreenOcean
DSM and Syngenta develop and
commercialize biological
solutions for agriculture
Sustainable fermentative Stevia to
replace sugarProducing omega-3 fatty acids for
animal nutrition without use of
fish
Sustainable biofuels CanolaPro™
Feed additives to significantly
reduce methane/GHG
emissions from cattle
Enzymes and yeast enabling
biofuels
Plant protein for foods and
beverages
Developing sustainable biological solutions to protect agriculture
Page 15
▪ Strong societal and industry need for sustainable solutions to
safeguard food and nutrition security
✓ Biocontrols market set for double-digit growth from
~US$1.5bn (2015) to >US$7bn by 20301
✓ By 2030 these could represent up to 10% of global crop
protection market
▪ Cooperation DSM and Syngenta makes excellent progress to
accelerate development these solutions
✓ DSM contributes unique leading microbial database, strong
screening competence and decades of experience in
scaling and manufacturing of microbial products
✓ Syngenta has specialized know-how in agri-applications,
plant biotechnology, global market access and commercial
strength
▪ Project with long-term focus and high potential
1 Source: Dunham Trimmer − July 2014 + Syngenta
Page 16
▪ Development and supply of high-value knowledge,
ingredients and expertise in the field of bio-conversion
technology are critical success factors
▪ Building on unique position in biotechnology we are leading
in cost-effective, high-yield enzymes and yeasts enabling
biofuels
▪ Our strategy is to license our technology and expertise to
bio-based entrepreneurs
▪ Based on breakthroughs achieved by DSM in the performance
of its enzymes, POET-DSM decided to manufacture the
enzymes on-site
Best-in-class enzymes and yeast enabling biofuels
Canola protein: turning an inedible by-product into valuable food protein
Page 17
▪ Plant-based proteins key for healthy, nutritious diet:
should be 10-15% of daily intake
▪ Currently available plant proteins do not ideally
comply with needs of consumers
▪ Market value of specialty food proteins is about
US$6.5 bln1
▪ DSM takes canola meal as raw material and extracts
food proteins
✓Good taste
✓ High solubility
✓ Non-GMO, non-gluten
▪ Demo unit up and running, strong market interest
and preparing to scale
1 Giract Food Ingredient Research 2015/2016 + DSM
Biotechnology is driving growth
Page 18
▪ Biotechnology offers substantial benefits over traditional chemical routes and natural
extraction routes
▪ DSM has a 150 year track record in biotechnology and a wide range of world class
(bio)technology platforms
▪ DSM’s rich biotechnology innovation pipeline driving growth, including:
✓ GreenOcean, omega-3 fatty acids for animal nutrition without use of fish
✓ CleanCow, feed additives to significantly reduce methane/GHG emissions from cattle
✓ Fermentative Stevia to replace sugar
✓ BioAlliance, biological solution for sustainable crop-protection
✓ Canola, plant-based proteins
Biotechnology pioneer with 150 years experience set to capture growth