Dosage Delivery System Operation Manual

© 2011 Distek, Inc.

Dosage DeliverySystem OperationManual

Operation Manual

Document: 3800-0170

Revision: A

Dosage Delivery System

Operation Manual

Document 3800-0170

© Distek , Inc.121 North Center Dr. • North Brunswick , NJ 08902Phone 732.422.7585 • Fax 732.422.7310http://www.distek inc.com

All rights reserved. No parts of this work may be reproduced in any form or by any means - graphic, electronic, ormechanical, including photocopying, recording, taping, or information storage and retrieval systems - without thewritten permission of Distek, Inc.

Products that are referred to in this document may be either trademarks and/or registered trademarks of therespective owners. Distek, Inc. makes no claim to these trademarks.

The information contained in the document is subject to change without notice.

While every precaution has been taken in the preparation of this document, Distek, Inc. assumes no responsibilityfor errors or omissions, or for damages resulting from the use of information contained in this document or from theuse of programs and source code that may accompany it. In no event shall Distek, Inc. be liable for any loss of profitor any other commercial damage caused or alleged to have been caused directly or indirectly by this document.

WarrantyThe material in this document is provided "as is", and is subject to changes without notice in future revisions. Distek, Inc. disclaims all warranties, either express or implied, with regard to this manual and any informationcontained herein, including but not limited to the implied warranties of merchantability and fitness for a particularpurpose. Distek, Inc. shall not be liable for errors or for incidental or consequential damages in connection with thefurnishing, use, or performance of this document or of any information contained herein.

Dosage Delivery System Operation Manual


© Distek , Inc.121 North Center Dr. • North Brunswick , NJ 08902Phone 732.422.7585 • Fax 732.422.7310http://www.distek inc.com

4ContentsDosage Delivery System Operation Manual


Table of Contents

Chapter 1 Introduction 6

................................................................................................................................... 71.1 Specifications & Requirements

................................................................................................................................... 81.2 Document Revision History

Chapter 2 Installation & Operation 10

................................................................................................................................... 112.1 Installation - Evolution 6300

................................................................................................................................... 142.2 Operation - Evolution 6300

................................................................................................................................... 162.3 Operation - Evolution 4300 Controlling an Evolution 6300

Index 18

Introduction

Chapter

1

IntroductionDosage Delivery System Operation Manual 6


1

IntroductionThe Dosage Delivery System is installed into the vessel cover and allows for automatic introduction ofthe dosage form (tablet, capsule, sinker, etc.) into the vessel.

Simultaneous sample delivery into non-stirring paddle (stand-alone Evolution 6100/6300,2100C and non-Distek dissolution baths).Automated options using the instrument programmed methods (Evolution series only).Option to manually introduce the sample by simply pushing the drop dosage push buttonswitch.Modularity allows the customer to specify the number of positions (1 to 8) desired, allowingthe flexibility for users to scale up the dissolution unit to meet their needs.Flexible enough to work with non-Distek dissolution instruments.



Specification

Dosage DeliverySystem

1 to 8 positions

Modeso Automated Programmed Method (Evolution series only)

o Manual

Interface Ports 1 RS-232

Dimensions (eachmodule)

Height: 1.6 inch (4 cm)Width: 2.0 inches (5 cm)Depth: 2.4 inches (6 cm)

Weight 2.8 ounces (79 grams) per module/position (not including wiring)

Electrical Power AC Power Adapter 100-240 Volts/2.5A /50-60 Hz

Requirements

Firmware Evolution 6100/6300 Rev. 2.17 and higher

Serial Cable

Standard DB-9 Male to Female

RS232 DB9 pin assignment



Document Revision History

Revision Date Comments

A 21 Jun 2011 Initial release

Manual Part Number3800-0170

Installation & Operation

Chapter

2

Installation & OperationDosage Delivery System Operation Manual 10


2

Installation and Operation

Installation and Operation contains information on how to properly install and operate the DosageDelivery Modules on a Evolution 6300 dissolution system.



Installation - Evolution 6300 The dosage delivery system is primarily used to introduce the sample when using paddles with pre-programmed methods.

Installation:

1 Locate the dosage delivery control box and peel off the paper backing of the Velcro strip. Installthe dosage delivery control box on the left hand side column of the dissolution bath as shownbelow.

Dosage Delivery System Control Box

2 Connect the DC power source from the adapter, the serial cable and the dosage deliveryconnector on the control box.

Control box hookup



3 Install the vessel covers intended for the dosage delivery modules. Position the vessel coversso that the hinge on the cover sits behind the shafts and the cover sits squarely on the vessels.

4 Loosen the two front feet that holds the water bath in place. Push down the water bath slightlyto partially separate it from the vessel plate.

Bath front support feet location

5 Install the two bath wiring bracket clips by sliding them on the lip of the water bath as shown. Locate the bath clips approximately in between the front four vessel positions (between vessels2 and 3, 4 and 5). Tighten the water bath support feet so that the bath creates a tight sealagainst the vessel plate. DO NOT OVER TIGHTEN THE BATH.

Bracket clip for wiring harness

6 Install the dosage delivery module onto the vessel covers by lining up the module's bottom tabswith the tabs on the vessel covers.



Module attached to vessel cover

7 Route the cables into the wire clips (3 each) as shown below. The other end of the cableharness can go underneath the dissolution bath towards the location of the control box.

Cable harness routing

Make sure that the module cables have enough slack for the end-user toinstall or remove the dosage delivery modules.Manage the cable of the tablet dropper so that it does not touch thestirring shafts.

8 Connect the plugs of the modules to the dosage delivery connector.

9 Connect the serial cable to the Evolution 6300 RS-232 serial port.

10 Connect the power supply to the appropriate AC outlet.



Operation - Evolution 6300

1 Evolution Series firmware Revision 2.17 or higher must be installed for theDosage Delivery System to work with the instrument.

Configure the Evolution 6300. From the main display screen, select SYSTEM CONFIG thenSYSTEM SETUP. In the system setup screen, change the setting on the Tablet Dropper toON (use + or - key to toggle the setting). Exit the SYSTEM SETUP by selecting HOME.

System Setup Setting

2 Create a Method. (Refer to the Evolution Operation Manual for more information.)

3 Select and Run a method. The instrument will start pre-heating the dissolution media. Thedisplay prompts the user that the Tablet Dropper is enabled. The user needs to select when tointroduce the samples. The following modes are available:

TEMP Samples are introduced after the set temperature and RPM are achieved.

Display Message, TEMP Selected (default)

TIME Samples are introduced at a specified time set by the user.

Display Message, Time Selected

When TIME is selected, the user needs to set the time to introduce the sample into the vessel.If the set temperature and RPM are not reached before the set drop time, the instrument will waituntil the settings are reached. This is true also if TEMP is selected.

Display Message, Specify Time

4 Once the preheating is complete, depending on the mode chosen to introduce the samples, the



samples are dropped into the vessel and the test timer starts.



Operation - Evolution 4300 Controlling an Evolution 6300

1 Evolution Series firmware Revision 2.17 or higher must be installed for theDosage Delivery System to work with the instrument.

Configure the Evolution 6300. From the main display screen, select SYSTEM CONFIG thenSYSTEM SETUP. In the system setup screen, change the setting on the Tablet Dropper toON (use + or - key to toggle the setting). Exit the SYSTEM SETUP by selecting HOME.

System Setup Setting

2 On the Evolution 4300 verify that bath communication has been configured and bath parametersare correctly set. See the Evolution 4300 Operation Manual for further information on configuringcommunication.

3 On the Evolution 4300 select START BATH from the Main screen.

4 The Evolution 4300 will display the message "PLEASE WAIT FOR BATH TEMPERATURE" onthe Main screen.

5 The dissolution instrument will start pre-heating the dissolution media. On the dissolutioninstrument, the display prompts the user that the Tablet Dropper is enabled. The user needs toselect when to introduce the samples. The following modes are available:

TEMP Samples are introduced after the set temperature and RPM are achieved.

Display Message, TEMP Selected (default)

TIME Samples are introduced at a specified time set by the user.

Display Message, Time Selected

When TIME is selected, the user needs to set the time to introduce the sample into the vessel.If the set temperature and RPM are not reached before the set drop time, the instrument will waituntil the settings are reached. This is true also if TEMP is selected.



Display Message, Specify Time

6 When the bath temperature has been reached the Evolution 4300 will display the message:

BATH_NAMEVESSEL TEMP HAS BEEN REACHED. PLEASEFOLLOW INSTRUCTIONS ON THE 6100/6300

7 Once the preheating is complete, depending on the mode chosen to introduce the samples, thesamples are automatically dropped into the vessels, the instruments and the test timer starts.

IndexDosage Delivery System Operation Manual 18


Index- D -Dimensions 7

- E -Electrical Power 7

Evolution 4300 16

Evolution 6300 Installation 11

Evolution 6300 Operation 14, 16

- F -Firmware 7

- I -Introduction 6

- R -Revision History 8

- S -Serial Cable 7

Specification 7

- W -Warranty 8

Weight 7

Documents

Dosage Delivery System Operation Manual