ANALYSIS OF UBCH10 EXPRESSION REPRESENTS A USEFUL TOOL FOR THE DIAGNOSIS AND THERAPY OF LUNG CANCER. Donato G., Conforti F., Zuccalà V., Amorosi A.. U.O. di Anatomia Patologica Università degli Studi di Catanzaro Magna Græcia. - PowerPoint PPT Presentation
Text of Donato G., Conforti F., Zuccalà V., Amorosi A.. U.O. di Anatomia Patologica
ANALYSIS OF UBCH10 EXPRESSION REPRESENTS A USEFUL TOOL FOR THE
DIAGNOSIS AND THERAPY OF LUNG CANCER
Donato G., Conforti F., Zuccal V., Amorosi A..U.O. di Anatomia
PatologicaUniversit degli Studi di Catanzaro Magna GrciaThe
expression of UbcH10 gene, that codes for a protein that belongs to
the ubiquitin-conjugating enzyme family, as a valid indicator of
the proliferative and aggressive status of tumors of different
origin. There is no expression of UBCH10 in normal lung.
Normal lung Therefore, to look for possible tools to be used as
diagnostic markers in lung neoplasias, we have investigated UbcH10
expression in low grade and high grade lungs tumors by
Non-small cell lung cancer
Small cell lung cancerOur data indicate a correlation between
UbcH10 expression and the histological grade of the lungs tumors.
It is possible that up-regulation of UbcH10 play a role in
progression of lungs tumors. Finally, since proteasome inhibitors
have been, recently, considered as possible drugs in the
chemotherapy of various tumors our results would suggest new
perspectives for the treatment of lung malignancies based on the
suppression of the UbcH10 function by these drugs.