Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)€¦ · Karen McCann, Financial Accounting Assistant Julie Murphy, Accounting/Purchasing Assistant Anna Santacruz, Administrative

Version 25, January 2020

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

The DIAN‐TU acknowledges the many individuals who have contributed to the DIAN‐TU Trials including funding partners, leadership team, core leaders, project arm leaders, study sites and institutional study partners listed in the following pages. All manuscripts should include one of the following statements of acknowledgement of the DIAN‐TU Team located at DIAN.wustl.edu.

General DIAN‐TU and/or DIAN‐TU Trial Platform (not drug specific or all drugs): The DIAN‐TU is supported by the Alzheimer’s Association, GHR Foundation, an anonymous organization, and the DIAN‐TU Pharma Consortium (https://dian.wustl.edu/our‐research/the‐pharma‐consortium/). The DIAN‐TU‐001 Trial has received support from the Alzheimer’s Association, Eli Lilly and Company, Roche, Janssen Pharmaceuticals, NIH U01AG042791, NIH U01AG042791‐S1 (FNIH and Accelerating Medicines Partnership), NIH R1AG046179, NIH R01/R56 AG053267, Avid Radiopharmaceuticals, Cogstate, Bracket, GHR Foundation, and an anonymous organization. We acknowledge the altruism of the participants and their families and contributions of the DIAN and DIAN‐TU research and support staff at each of the participating sites (https://dian.wustl.edu/wp‐content/uploads/2019/04/DIAN‐TU‐Publications_Acknowledgement_V25.pdf) for their contributions to this study.

DIAN‐TU Trial Platform ‐ Sola/Gant specific: The DIAN‐TU is supported by the Alzheimer’s Association, GHR Foundation, an anonymous organization, and the DIAN‐TU Pharma Consortium (https://dian.wustl.edu/our‐research/the‐pharma‐consortium/). This research for the DIAN‐TU‐001 Trial has received support from the Alzheimer’s Association, Eli Lilly and Company, Roche, NIH U01AG042791, NIH U01AG042791‐S1 (FNIH and Accelerating Medicines Partnership), NIH R1AG046179, Avid Radiopharmaceuticals, Cogstate, Bracket, GHR Foundation, and an anonymous organization. We acknowledge the altruism of the participants and their families and contributions of the DIAN and DIAN‐TU research and support staff at each of the participating sites (https://dian.wustl.edu/wp‐content/uploads/2019/04/DIAN‐TU‐Publications_Acknowledgement_V25.pdf) for their contributions to this study.

DIAN‐TU Trial Platform – Atabecestat specific: The DIAN‐TU is supported by the Alzheimer’s Association, GHR Foundation, an anonymous organization, and the DIAN‐TU Pharma Consortium (https://dian.wustl.edu/our‐research/the‐pharma‐consortium/). This research for the DIAN‐TU‐001 Trial has received support from the Alzheimer’s Association, Janssen Pharmaceuticals, NIH R01/R56 AG053267, GHR Foundation, and an anonymous organization. We acknowledge the altruism of the participants and their families and contributions of the DIAN and DIAN‐TU research and support staff at each of the participating sites (https://dian.wustl.edu/wp‐content/uploads/2019/04/DIAN‐TU‐Publications_Acknowledgement_V25.pdf) for their contributions to this study.



Publication Authorship: The overarching considerations for DIAN‐TU publications are collaboration and inclusiveness. When studies use DIAN‐TU Trial data and/or biospecimens processed by the DIAN‐TU Coordinating Center Cores, an invitation to collaborate (meriting authorship) on the manuscript should be issued to respective DIAN‐TU Study Team Members as defined below:

DIAN‐TU Study Team Members (see complete list of individuals on pages 3‐20)

Invite to co‐author:

Leadership Team Pharma Partners Core Leaders (Core leaders may include staff member, fellow, co‐investigator) Site Principal Investigators

Acknowledge: DIAN‐TU Staff Pharma Teams Commercial Vendors and Collaborators DSMB Members Therapy Evaluation Committee Clinical Trials Committee Data Sharing and Communications Committee DIAN EXR Referring Clinicians and Researchers DIAN‐TU Advisers and Collaborators



Funding Partners Through public/private support and partnership, the DIAN‐TU has launched trials to provide advancement of treatments, scientific understanding and improvements in the approach to Alzheimer’s disease drug developments. DIAN‐TU Trial Pharma Partners: Lilly (Solanazemab), Roche (Gantenerumab) and Janssen (BACEi)

Alzheimer’s Association GHR Foundation National Institute on Aging of the National Institutes of Health; Accelerating Medicines

Partnership (AMP) ‐ U01 AG042791, R01 AG046179, R01/R56 AG053267, R13 AG055232 DIAN‐TU Pharma Consortium: Biogen Idec, Eisai, Janssen, Lilly, Roche/Genentech, United

NeuroScience (Former Members: Abbvie, Amgen, AstraZeneca, Elan, Forum, Mithridion, Novartis Pharm AG, Pfizer, Sanofi‐Aventis)

CogState Bracket Avid Radiopharmaceuticals Anonymous Foundation

Leadership Team

Washington University School of Medicine, Department of Neurology Randall Bateman, MD Eric McDade, DO Director and Principal Investigator DIAN‐TU Associate Director, DIAN‐TU

David Clifford, MD Medical Director

Project Arm Leaders Steve Salloway, MD, Gantenerumab Martin Farlow, MD, Solanazemab Butler Hospital Indiana University

Lon Schneider, MD, BACE Butler Hospital Pharma Partners Eli Lilly Hoffman La‐Roche Janssen John Sims Greg Klein Gary Romano Cheryl Brown Smilijana Ristic Hong Sun Eric Siemers (retired) Monika Baudler Luc Tritsman (retired)



DIAN‐TU Core Leaders

Randall Bateman, MD Administrative Core Leader Washington University School of Medicine Anne Fagan, PhD Biomarker Core Leader Washington University School of Medicine Chengjie Xiong, PhD Biostatistics Core Leader Washington University School of Medicine Guoqiao Wang, PhD Biostatistics Co‐Core Leader Washington University School of Medicine Jason Hassenstab, PhD Cognition Core Leader Washington University School of Medicine Alison Goate, DPhil Genetics Core Leader Mt. Sinai School of Medicine Carlos Cruchaga, PhD Genetics Core Leader Washington University School of Medicine Tammie Benzinger, MD Imaging Core Leader Washington University School of Medicine Rick Perrin, MD Neuropathology Core Leader Washington University School of Medicine Cliff Jack, MD MRI, Mayo Clinic Robert Koeppe, MD PET Imaging, University of Michigan

Nigel Cairns, MD (retired) Neuropathology Core Leader Washington University School of Medicine

Peter Snyder, PhD (Former Cognition Core Leader) Brown University



DIAN‐TU Staff

Administration Garland Edmonds, Accounting/Purchasing Assistant

Amanda Fulbright, Grant Specialist

Jacki Mallmann, Senior Grant Specialist

Karen McCann, Financial Accounting Assistant

Julie Murphy, Accounting/Purchasing Assistant Anna Santacruz, Administrative Director

Jeanette Schillizzi – Research Administrator

Shannon Sweeney, Finance Analyst

Linda Watkins‐Imhof, Accounting/Purchasing Assistant

Biomarker Kelley Coalier, Lead Scientist

Matt Amos, Lead Technician

Fatima Amtashar, QC Technician

Sushila Sathyan, Archivist

Clinical Operations

Susan Mills – Director of Clinical Operations

Nicole Kelley ‐ Associate Director of Clinical Operations

Stephanie Belyew ‐ Clinical Research Development Coordinator, Site, Vendor and GCP Management

Angela Fuqua ‐ Clinical Research Development Coordinator, Clinical Scale, Drug Supply and Vendor Management

Annette Stiebel ‐ Clinical Research Development Coordinator

Caryll Bentley ‐ Contract Project Manager

JaNeen Wisner ‐ Contract Project Coordinator

Tayona Mayhew ‐ Data Management Specialist

Zenobia Bridgewater ‐ Clinical Research Coordinator

Erin Cattoor ‐ Research Nurse Coordinator II

Molly Fitzgerald – Clinical Research Study Assistant I

Erica Fowler ‐ Clinical Research Coordinator I

Kurtis Hanks ‐ Clinical Research Coordinator I

Dottie Heller ‐ Research Nurse Coordinator II

Latoya Jones ‐ Clinical Research Coordinator II

Paulette MacDougall ‐ Research Nurse Coordinator II

Michelle Jorke ‐ Clinical Research Coordinator II

Eugene Rubin ‐ QC

Jessi Smith ‐ Senior Clinical Research Coordinator

Marisol Tahan ‐ Clinical Research Coordinator

Mary Wolfsberger ‐ Clinical Research Coordinator

Biostatistics Yan Li ‐ Co‐Investigator

Xu Xiong ‐ Database Manager

Cognition Andy Aschenbrenner – Research Instructor

Jennifer Smith ‐ Professional Rater III

DIAN Expanded Registry (DIAN EXR) Eric McDade ‐ Director

Randall Bateman – Associate Director

Jorge Llibre‐Guerra – Post‐Doctoral Associate

Ellen Ziegemeier ‐ Senior Clinical Research Coordinator

Jennifer Petranek ‐ Clinical Coordinator I

Sarah Adams ‐ Clinical Research Coordinator II

Susan Brandon ‐ Clinical Research Coordinator II

DIAN‐TU Post‐Doctoral Associate(s) Jorge Llibre‐Guerra – Post‐Doctoral Associate

Imaging Theresa Butler ‐ Research Lab Manager

Lisa Cash ‐ Senior Clinical Research Coordinator

Jon Christensen ‐ Staff Scientist

Aylin Dincer ‐ Research Assistant

Tony Durbin ‐ Senior Clinical Research Coordinator

Shaney Flores ‐ Research Assistant

Karl Friedrichsen ‐ Research Assistant

Brian Gordon ‐ Co‐Investigator

Russ Hornbeck ‐ Project Manager

Nelly Joseph‐Mathurin ‐ Post‐doc

Sarah Keefe ‐ Research Assistant

Lakisha Lloyd ‐ Research Coordinator

Laura Marple ‐ Research Technician II

Austin McCullough ‐ Graduate Research Assistant

Jeanine Portell ‐ Senior Clinical Research Coordinator

Stephanie Schultz ‐ Pre‐Doctoral Trainee

Sally Schwarz ‐ Co‐Investigator

Yi Su ‐ Co‐Investigator

Andrei Vlassenko ‐ Co‐Investigator

Qing Wang ‐ Post‐doc

Jinbin Xu ‐ Co‐Investigator

Neuropathology Erin Franklin ‐ Research Coordinator

Erin Cattoor ‐ Research Nurse Coordinator II



Eli Lilly Team John Sims, GBD Leader and Senior Medical Director Cheryl Brown, COO Roy Yaari, Senior Medical Advisor Karen Chilcotte Holdridge, CRS Isabella Velona, Clinical Trial Project Manager Scott Andersen, Biostatistician Michele Mancini, GPS Brian Willis, PK/PD Project Leader Sonia Nijampatnam, Pharmaceutical Project Management Kathryn Broderick, Global Regulatory Affairs Julie Bush, Product Delivery Shamrock Garrett, Sr. CTMA Traci Peddie, Data Sciences & Solutions Natalie Vantwoud, Data Management Barbara Lightfoot‐Owens, Medical Writer John Brad‐Holmes, Central Lab

Former

Phyllis Ferrell Barkman Russ Barton Lauren Brunke Robert Dean Deanilee Deckard Ann Catherine Downing Ganapathy Goppalrathnam David Henley Janice Hitchcock Tracie Peddie Melissa Pugh Tami Jo Rayle Shiloh Scott James Senetar Gopalan Sethuraman Eric Siemers Brian Steuenwald Connie Tong Jim Vandergriff

Avid Michael Devous Erica Elephant Laura Harper Marybeth Howlett Mark Mintun Michael Pontecorvo



Hoffman‐LaRoche Team Monika Baudler, LifeCycle Leader

Rachelle Doody, Global Head of Neurodegneration

Paul Delmar, Principal Statistical Scientist

Carsten Hofmann, Clinical Pharmacologist

Michaela Jahn, Global Biometrics Team Leader

Geoff Kerchner, Global Development Leader

Gregory Klein, Biomarker Experimental Medicine Leader

Smiljana Ristic, Associate Group Medical Director

Alison Searle, Operations Program Leader

Marco Sonderegger, Technical Development Leader

Roz Sutton, EU Regulatory Partner

Janette Turner, US Regulatory Partner

Jaku Wojtowicz, Safety Science Director

Susan Yule, Global Regulatory Leader

Former Elizabeth Ashford, Operations Program Leader Bogdon Balas, Safety Science Leader Estelle Vester‐Blokland, LifeCycle Leader Stephanie Capo‐Chichi, EU Regulatory Partner

David Agnew, Global Study Manager Ernest Dorflinger, Translational Medicine Leader Efe Egharevba, Global Study Manager Christelle Laroche, Technical Development Leader

Isabelle Bauer Dauphin, Technical Development Leader Rob Lasser, Global Development Leader Ferenc Martenyi, Global Development Leader Glenn Morrison, Global Development Leader Tania Nikolcheva, Biomarker Experimental Medicine Leader Michael Rabbia, Statistical Scientist Juha Savola, Project Leader Janice Smith, Clinical Science Leader Dietmar Volz, Statistical Scientist



Janssen Team Caitlin Beatty

Jennifer Bogert

Miranda Damen

Carol Davies

Marisa Ehinger

Suzanne Foy

Monique Franc

Betty Guinter

Katrin Haeverans

Megan Katz

Hartmuth Kolb

Cathy Marseca

Reena Mistry

Sophie Morin

Gary Romano

Maria Schpatschynskyj

Hong Sun

Monika Sulidis

Luc Tritsman



The following should be acknowledged in DIAN‐TU Publications Commercial Vendors and Collaborators DSMB Members Therapy Evaluation Committee Clinical Trials Committee Data Sharing and Communications Committee DIAN EXR Referring Clinicians and Researchers DIAN‐TU Advisers and Collaborators

DIAN‐TU Commercial Vendors and Collaborators IQVIA Lynne Hughes Miriana Vankov Denise Dormody Ryan Thompson Frederique Alary Carla Hancock Kim Hughes Eva Irmy David Margolin, MD Olja Tanjga, MD Deitra Wade

Berry Consultants Scott Berry Melanie Quintana Barbara Wendelberger

CogState Granzer Regulatory Consulting Cardinal Health Regulatory Sciences Signat



DIAN‐TU DSMB Members

The DSMB is an expert advisory group who functions as a review committee independent from the Sponsor. DSMB members meet without the Sponsor or study team members to review and discuss provided data. The DSMB scope is to review study data to ensure the safety of subjects enrolled in DIAN‐TU‐001.

Gary Cutter, DSMB Chairperson

Steve Greenberg

Scott Kim

David Knopman

Willis Maddrey (Retired)

Kristine Yaffe

Karl Kieburtz (Retired DSMB Chairperson)

Allan Levey (Retired)

DIAN‐TU Data Sharing and Communications Committee

Andy Aschenbrenner, PhD, Committee Chair Anna Santacruz, Administrative Director



DIAN‐TU Therapy Evaluation Committee The DIAN‐TU established a Therapy Evaluation Committee comprised of worldwide experts in AD research and clinical studies from multiple institutions to vet and evaluate compounds nominated for participation in the DIAN‐TU trial. Areas of expertise include clinical trials in AD and other diseases, autosomal dominant and sporadic AD, immunotherapy, neurodegenerative disorders, cell and molecular biology of AD, preclinical AD studies, proteomics (AD related proteins), AD neuropathology, cognitive and clinical testing, cerebral amyloid angiopathy, neuroimaging, translational AD trials, and tau biology. Randall Bateman, MD, Chair, Washington University Eric McDade, DO, Co‐Chair, Washington University Paul Aisen, MD, Alzheimer's Therapeutic Research Institute (clinical trials)

Jasmeer Chhatwal, MD, PhD, MMSc, Massachusetts General Hospital, Harvard Medical School (imaging)

David Clifford, MD, Washington University School of Medicine (Medical Director, DIAN‐TU Trials)

David Cribbs, MD, UC Irvine (immunotherapy)

Nick Fox, MD, FRCP, FMedSci, Dementia Research Centre (genetics)

Serge Gauthier, Serge Gauthier, CM, MD, FRCPC, Director, AD & Related Disorders Unit

McGill Centre for Studies in Aging (clinical trials)

David Holtzman, MD, Washington University School of Medicine (neurodegeneration, animal models)

Matthias Jucker, PhD, Hertie Institute for Clinical Brain Research (translational AD)

Jeff Kelly, MD, Scripps (proteomics)

Virginia Lee, PhD, University of Pennsylvania, Perelman School of Medicine (tau biology)

Simon Mead, FRCP, PhD, Institute of Prion Diseases (genetics)

Cath Mummery, PhD, FRCP, Dementia Research Centre (genetics)

Erik Musiek, MD, PhD, Washington University School of Medicine (translational AD)

Erik Roberson, MD, PhD, University of Alabama (tau proteins)

Mathias Staufenbiel, PhD, Hertie Institute for Clinical Brain Research, Tubingen (pre‐clinical and clinical AD studies)

Robert Vassar, PhD, Northwestern (cell and molecular biology)

Former TEC Members

Bart DeStrooper, PhD, VIB, K.U. Leuven, Germany

William Klunk, MD, PhD, University of Pittsburgh, Pennsylvania

Cynthia Lemere, MD, Brigham and Women’s Hospital, Boston, Massachusetts

John C. Morris, MD, Washington University School of Medicine, St. Louis, Missouri



Clinical Trials Committee (CTC) Members

Randall Bateman, Washington University in St. Louis School of Medicine

John Morris, Washington University in St. Louis School of Medicine

Chengjie Xiong, Washington University in St. Louis School of Medicine

Denise Heinrichs, DIAN Family Representative

John Ringman University of California, Los Angeles

Laurie Ryan, Division of Science, National Institute on Aging

Neil Buckholtz, National Institute on Aging

Reisa Sperling, Director, Center for Alzheimer Research and Treatment

Stephen Salloway, Butler Hospital

Paul Aisen, University of California, San Diego

Anna Santacruz, Washington University in St. Louis School of Medicine

Gabrielle Strobel, Alzheimer Research Forum

Bill Klunk, University of Pittsburgh

William Thies, Alzheimer's Association

CTC Steering Committee Members

Anne Fagan, Washington University in St. Louis School of Medicine

Mark Mintun, Washington University in St. Louis School of Medicine

Natalie Ryan, University College London

Virginia Buckles, Washington University in St. Louis School of Medicine

David Hawver, FDA

Martin Farlow, Indiana University

Maritza Ciliberto, DIAN Family Representative

Ralph Martins, Edith Cowan University

Jennifer Williamson, Columbia University



Study Sites

Argentina Insituto de Investigaciones Neurologicas Fleni https://www.fleni.org.ar/especialidades/neurologia/neurologia‐cognitiva‐neuropsicologia‐y‐neuropsiquiatria/ Ricardo F. Allegri Principal Investigator

Patricio Chrem Mendez Co‐Investigator

Lucia Crivelli Neuropsychologist

Ezequiel Surace Biologist

Gustavo Sevlever Neuropathologist

Silvia Vazquez Imaging Principal Investigator

Luciana Armanini Study Coordinator

Australia Neuroscience Research –Sydney (SG, AV) William Brooks Principal Investigator

Michael J Fulham Imaging Principal Investigator

Jacob Bechara Study Coordinator

David Foxe CDR assessments

Australian Alzheimer’s Research Foundation – Perth (SG) Roger Clarnette Principal Investigator

Nick Reynders Imaging Principal Investigator

Paula Mather Study Coordinator

University of Melbourne – Melbourne (SG, AV) Colin Masters Principal Investigator

Christopher Rowe Imaging Principal Investigator

Bev Clinch Study Coordinator

David Baxendale Back up Coordinator

Brazil University of São Paulo Ricardo Nitrini Principal Investigator

Legend for site participation: SG = Solanazemab and Gantenerumab arms; B = BACE; MK = MK6240 Tau; AV = AV1451 Tau; CRI = Cognitive Run‐in



Study Sites (continued)

Canada Douglas Hospital Research Centre (SG, AV) Serge Gauthier Principal Investigator

Pedro Rosa‐Neto Imaging Co‐Investigator

Carley Mayhew Study Coordinator

Laura Robb Back up Coordinator

Vancouver Coastal Health Authority (SG, AV) Robin Hsiung Principal Investigator

Dan Worsley Imaging Principal Investigator

Michele Assaly Study Coordinator

Eloise Nicklin Back up Coordinator

Sunnybrook Health Science Centre (SG, AV) Mario Masellis Principal Investigator Katie Sharp Study Coordinator

Stephanie Hetherington Back up Coordinator

Universite Laval Robert Laforce Principal Investigator

Colombia Grupo de Neurociencias Sede de la Universidad de Antioquia Francisco Lopera Principal Investigator

Yakeel Quiroz Sub‐Investigator




Study Sites (continued) France CHU de Rouen (SG, AV) www.alzheimer‐genetique.fr David Wallon, MD, PhD Principal Investigator

Didier Hannequin, MD, PhD Sub‐investigator

Alexandre Morin, MD Sub‐Investigator

Aline Zarea, MD Sub‐investigator

Emmanuel Gerardin, MD, PhD MRI Neuroimaging Investigator

Pierre Bohn, PharmaD Imaging principal Investigator

Mathieu Chastan, MD Imaging Sub‐Investigator

Pierre Vera, MD, PhD Imaging Sub‐Investigator

Marion Colnot, Pharma D Hospital Pharmacist

Nathalie Donnadieu, PharmaD Hospital Pharmacist

Muriel Quillard‐Muraine, MD, PhD Biologist

Celine Bergot Study Coordinator Severine Jourdain Back‐up Study Coordinator Hopital Larrey – Angers (SG) Valérie Chauviré, MD Sub‐investigator Frédérique Etcharry‐Bouyx, MD Sub‐investigator

Groupe Hospitalier Pitie (SG, AV) Bruno Dubois Principal Investigator

Marie‐Odile Habert Imaging Principal Investigator

Nadjia Younsi Back up Coordinator

Hopital Neurologique Pierre Wertheimer– Lyon (SG) Maite Formaglio Principal Investigator

Didier Lebars Imaging Principal Investigator

Najat El Kfif Study Coordinator

Aurélie Jullien Back up Coordinator

CHU de Toulouse (SG, AV) Jereme Pariente Principal Investigator

Pierre Payoux Imaging Principal Investigator

Claire Thalamas CID

Amel Driff CRA

Elsa Pomies Neuropsychologist Pascale Gauteul Study Coordinator





France (continued) Centre Hospitalier Unversitaire - Lille (SG, AV) Florence Pasquier Principal Investigator Adeline Rollin‐Sillaire Co‐Investigator

Franck Semah Imaging Principal Investigator Laetitia Breuilh Study Coordinator Manon Laforce Back up Coordinator Michael Bottlaender, MD, PhD Imaging Principal Investigator

Orsay Imaging Michael Bottlaender, MD, PhD Imaging Principal Investigator

Germany German Center for Neurodegenerative Diseases (DZNE), Universitaetsklinikum Tuebingen Christoph Laske Principal Investigator

Ludwig-Maximilians-Universität Johannes Levin Principal Investigator

Adrian Danek Principal Investigator (retired)

Jonathan Vöglein Co‐Investigator

Igor Yakushev Imaging Principal Investigator

Siri Houeland di Bari Study Coordinator

Ireland St. Vincent’s University Hospital Justin Kinsella Principal Investigator

Gillian O'Boyle Study Coordinator

Italy

Azienda Ospedaliera Universitaria Careggi Sandro Sorbi Principal Investigator

IRCCS Centro San Giovanni di Dio Fatebenefratelli Giovanni Frisoni Principal Investigator

Sara Gipponi Study Coordinator

Michela Rampini Study Coordinator

Anna Mega Genetic Counseling

Emilio Di Maria, MD Geneticist

Samantha Galluzzi, MD Geriatrician

Amalia Cecilia Bruni Neurologist

Nicoletta Smirne Statistician

Valentina Laganà Psychologist

Fabrizio Tagliavini Neurologist

Cristina Muscio Psychologist

Alessandro Padovani Neurologist

Barbara Borroni Neurologist

Elio Scarpini Neurologist

Gabriella Salvini Porro President, Federazione Alzheimer Italia




Study Sites (continued) Mexico Instituto Nacional de Neurologica y Neurocirugla Ana Luisa Sosa Principal Investigator

Longoria Mariana Co‐Investigator

Netherlands Amsterdam University Medical Centers Phillip Scheltens Principal Investigator

Spain Hospital Clinic I Provincial de Barcelona (SG, B, AV) Raquel Sanchez‐Valle Principal Investigator

Mircea Balasa Co‐Investigator

Albert Lladó Co‐Investigator

Beatriz Bosch Study Coordinator

Nuria Bargalló Imaging Co‐Investigator

Ignacio Banzo Imaging Co‐Investigator

Andres Perisinotti Imaging Principal Investigator

United Kingdom

University College London Hospital (SG)

Catherine Mummery Principal Investigator

Irfan Kayani Imaging Principal Investigator

Jane Douglas Study Coordinator

Miguel Grilo Co‐Investigator





United States Washington University, St. Louis, Missouri (SG, B, AV, MK)

Barbara J. Snider, MD Principal Investigator

Tammie Benzinger, MD Imaging Principal Investigator

Wendy Sigurdson, RN Study Coordinator

Tamara Donahue, RN Study Coordinator

Peggy Kelly, RN Study Coordinator

Emory University, Atlanta, Georgia (SG, B, AV, MK) James Lah Principal Investigator

Carolyn Meltzer Imaging Principal Investigator

Gail Schwartz Study Coordinator

Phyllis Vaughn Study Coordinator

Lydia Piendel Study Coordinator

University of Pittsburgh, Pennsylvania (SG, B, AV, MK) Sarah Berman Principal Investigator

James Mountz Imaging Principal Investigator

Lori Macedonia Study Coordinator

Snezana Ikonomovic Back up Coordinator

Sarah Goldberg, M.S. Neuropsychometrist

Elise Weamer, MPH Neuropsychometrist

James Ruskiewiecz, BS PET Research Manager

Steven Hegedus MR Research Assistant

Lee Tarr MR Research Technologist

Tom Potter MR Research Technologist

Gina Valetti MR Research Technologist

University of Alabama at Birmingham (SG, B, AV, MK)

Erik D. Roberson Principal Investigator

David S. Geldmacher Co‐Investigator

Marissa Natelson Love Co‐Investigator

Amber Watkins Study Coordinator

Loren Ashley Back up Coordinator

Indiana University (SG, B, AV, MK)

Jared R. Brosch, M.D. Principal Investigator

Brand Mathews, M.D. Former Principal Investigator

Arlene Kohn Study Coordinator

Nancy McClaskey, RN Study Coordinator

Jill Buck, RN Study Coordinator

James Fletcher Imaging Principal Investigator

Butler Hospital, Providence, Rhode Island (SG, B, AV, MK) Ghulam Surti Principal Investigator

Richard Noto Imaging Principal Investigator

Courtney Bodge Study Coordinator

William Menard Back up Coordinator





United States University of Puerto Rico (SG, B, AV, MK) Ivonne Z. Jimenez Velazquez Principal Investigator

Janice Diaz Study Coordinator

Karen Aleman Study Coordinator

Yale University, New Haven, Connecticut (SG, B, AV, MK) Christopher Van Dyck Principal Investigator

Ming‐Kai Chen Imaging Principal Investigator

Nina Diepenbrock Study Coordinator

Adam Mecca, MD, PhD Sub‐Investigator

Susan Good, APRN Study Nurse

University of California, San Diego (SG, B, AV, MK) Doug Galasko Principal Investigator

Carl Hoh Imaging Principal Investigator

Dan Szpak Study Coordinator

Shawnees Peacock Back up Coordinator

University of Washington (SG, B, AV, MK) Suman Jayadev Principal Investigator

David Lewis Imaging Principal Investigator

Yeung Tuttero Study Coordinator

Advocate Lutheran General Hospital, Park Ridge, Illinois Darren Gitelman Principal Investigator

Victoria Begoun Study Coordinator

Evelyn Torres Back up Coordinator

AUSC Keck School of Medicine, Los Angeles, California Sonia Pawluczyk Principal Investigator

Columbia University, New York City (SG, B, AV, MK) Lawrence Honig Principal Investigator

Chaitanya Divgi Imaging Principal Investigator

Ruth B. Tejeda Rater

Solciris A. Dominguez Rater

Katrina Cuasay Rater

Evelyn Dominquez‐Rivera Study Coordinator

Kerwin Research Center, Dallas, Texas Diana Kerwin Principal Investigator

Micah Eimberbrink, PhD Head of Research Operations Legend for site participation: SG = Solanazemab and Gantenerumab arms; B = BACE; MK = MK6240 Tau; AV = AV1451 Tau; CRI = Cognitive Run‐in



DIAN EXR Referring Clinicians and Researchers

Neelum T. Aggarwal, MD, Rush University Medical Center, Chicago IL Tom Ala, Center for Alzheimer’s Disease and Related Disorders, Southern Illinois University School of Medicine Thomas Bird, University of Washington Sandra E. Black, Sunnybrook Health Sciences Centre, University of Toronto William J. Burke, MD, Banner Alzheimer’s Institute Cynthia M. Carlsson, MD, MS, University of Wisconsin School of Medicine and Public Health Andrew Frank M.D. B.Sc.H. F.R.C.P.(C), Bruyere Continuing Care, Ottawa, Ontario, Canada James E. Galvin, MD, MPH, Charles E. Schmidt College of Medicine, Florida Atlantic University Alvin C Holm, MD, Bethesda Hospital, St. Paul, MN John S.K. Kauwe, Brigham Young University David Knopman MD, Mayo Clinic, Rochester MN Sarah Kremen, MD, University of California, Los Angeles Alan J. Lerner, University Hospitals Cleveland Medical Center Barry S. Oken, MD, PhD, Oregon Health & Science University Hamid R. Okhravi, Eastern Virginia Medical School Ronald C. Petersen, Mayo Clinic Aimee L. Pierce, MD, University of California Irvine Marsha J. Polk, MED, University of Texas Health Science Center at San Antonio John M. Ringman, MD, MS, University Southern California Sanjeev N. Vaishnavi, MD, PhD, University of Pennsylvania Sandra Weintraub, Northwestern University Feinberg School of Medicine

DIAN‐TU Collaborators and Advisers

John Morris, MD, Senior Advisor David Holtzman, MD, Senior Advisor Thomas Bird, MD, University of Washington Dennis Dickinson, MD, Mayo Clinic, Jacksonville, FL Peter St. George Hyslop, MD, FRS, FRSC, FRCPC, University of Toronto M. Marsel Mesulam, MD, Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University Cornelia Kamp, MBA, University of Rochester ADCS Ron Thomas, PhD Paul Aisen, MD

Documents

Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)€¦ · Karen McCann, Financial Accounting Assistant Julie Murphy, Accounting/Purchasing Assistant Anna Santacruz, Administrative