Institite Pasteur of Iran

Institite Pasteur of Iran

Biotechnology Department,

P.O.Box: 13146

Telefax: 98 21 648 07 80

Fax: 98 21 646 51 32

E. mail: shahbazzadeh@yahoo.com,

delavar@institute.pasteur.ac.ir

CURRICULUM VITAE

SHAHBAZZADEH, Delavar

Personal Information

Marital status: Married with three children

Nationality: Iranian

Date of birth: 1958.03.23

Place of Birth: Tehran-Iran

Home address: Pasdaran, 10th Baharestan, Maryam Alley, No. 31, 2rd-Floor,

Postal Code: 1958816116 Tehran-IRAN

Cell phone: 09126905795

Education

2004~2005

Post Doctorate Fellowship in Pasteur Institute of Tunis.

Title of the project: Characterization of Iranian scorpion venoms.

1990-1995

Doctor of Philosophy (Ph.D) in Medical Biochemistry, Hokkaido UniversitySchool of Medicine, Sapporo, Japan.

Dissertation title: Estrogen binding activity of recombinant alpha-fetoproteinexpressed in yeast.

1981-1987

Doctor of Veterinary Medicine (DVM) from Tehran University.

Thesis title: Surveying in Saprolegniasis disease in Rainbow fish in Iran.

Positions

1996~Present, Faculty Assistant Professor, Biotechnology Dept., Pasteur Institute of Iran, Tehran-Iran.

2002-2004, Head of Biotechnology Department, IPI.

Member of Higher Scientific Board of IPI.

Member of Scientific Biochemistry Committee of IPI.

Member of Network of Association Committee of Institute Pasteurs (ACIP) in Venom Research.

Awards

Receiving Five-years scholarship for Ph.D. Program from MONBUKAGAKUSHO of Japan (1990-1995).

Receiving three-months fellowship from Ministry of Health and Medical Education (2002).

Receiving One-year post-doctorate fellowship from Institute Pasteur of Paris (2005).

Area of Research

Sub cloning and Eukaryotic Gene expression, --

Recombinant DNA Technology, proteomics.

Venom and Toxins study: protein purification, HPLC, cysteine mapping, N-terminal sequencing, tandem mass spectrometry analysis, and peptide mass fingerprinting.

Electrophysiology: Na+ and K+ voltage-gated channel.

Nanotechnology, nano-antibodies.

Projects

1997-1999

Expression of human Alpha-feto protein (AFP) in yeast in order to design AFP diagnostic kit.

1999-2001

Chemical synthesis of GnRH in industrial scale for the treatment of ovarian cystic disorders in veterinary medicine.

2001-2003

Epidemiological survey and clinical characteristics of the scorpion envenomation in Khuzestan province of Iran.

2002-2005

Chemical synthesis of Prostaglandin F2 in industrial scale and its application in ovarian disorders in large animals.

2007-2009

Immunological characterization of Iranian (Khuzestan) scorpion Hemiscorpius lepturus venom in animal model in order to detect the immunogenic proteins

2007-2008

Toxic Effect of Hemiscorpiuos lepturus venom on liver carbohydrate enzymes , thyroid, testosterone and liver histology.

2008-2011 (IP-Tunis, Joint Actions INTERPASTEURIENNES Project-ACIP)

Peptide design and synthesis with high affinity and selectivity for the channels potassium of the Kv1.3 type.

Workshops & Training attended

1. Using PCR for detection of animal diseases (Rinder Pest and PPR), directed by Dr. Tom Barrett from PirBright, England, 15-22 July 1995.

2. Mycotoxins and antibiotic residues in milk and foodstuffs, directed by Dr. Ralf Drener from R-Biopharm GmbH, Germany, 18-21 Nov. 1995.

3. Using RT-PCR for detection of HCV from patients. By Dr. Shaheed Jamil, in Pasteur Institute of Iran, 15-22 Oct., 1997.

4. Pharmaceutical GMP, 18-22 October 2001, Iranian Veterinary Organization, Ministry of Jihad, Tehran, Iran.

5. Molecular methods: DNA extraction, Restriction analysis, Transformation, Digestion, and Electrophoresis. Pasteur institute of Iran, Medical Biotechnology Network, Biotechnology Department.

6. Protein analysis methods Including: amino acid hydrolysis, amino acid analysis, and reverse phase methods., Protein chemistry lab, Medical Biotechnology Network, Biotechnology Department, Pasteur institute of Iran.

7. HPLC system., Protein chemistry lab., Medical Biotechnology Network, Biotechnology Department, Pasteur institute of Iran.

8. Mass Spectrometry workshop, 26 April., 2005, Institute Pasteur of Tunis, Tunis.

Collaborations

2002~Present

International Network of Institute Pasteurs (ACIP) including: Tunis, Algeria, Morocco, Iran and Paris.

2003~Present

Cancer Research Centre of Karolinska, Sweden.

2001~Present

Health Centre of Khuzestan Province, Ahwaz, Iran. 2001~present

Health Centre of Kerman Province, Kerman, Iran. 2004

Lectures and Seminars

1. Estrogen binding site of Rat Alpha-Fetoprotein, International society for oncodevelopmental biology and medicine (ISOBM), Seminar 6-10 Sep. 1992 Sapporo Japan.

2. Production of subunit vaccines in biotechnology, Seminar held in Industrial and Scientific Research Organization in Tehran Feb. 1995.

3. Expression of human AFP in Saccharomyces cerevisiae. 4th Biochemistry Congress. 19-22 Oct. 1997, Babol, Iran.

4. Shaabani A, Kazemi B, Karimi M, Shahbazzadeh D, Ghadiri A. and Mahboudi F. (1999). Cloning and expression of leishmania gp63 gene in pichia pastoris. First congress of Iranian Biotechnology. Feb. 1999.Tehran. I.R.

5. Shahbazzadeh, D., Amirkhani, A., Ddjadid, N., Karimi, V. Study on scorpion envenomation in Iran, Khuzestan province during 2003-2004. The 2nd Iranian Epidemiol. Congress, Zahedan, 16-18 Feb., 2005.

6. Mansouri, P., Nahvandi, A, Shahbazzadeh, D., Karimpour M. Familial systemic lupus erythematosus and NOS gene polymorphism-A case report. 2nd Congress of Dermatology, 3 & 4 Feb. 2005, Iran University of Medical Sciences, Tehran, Iran.

7. Snake and scorpion envenomation workshop, 4 March, 2004, Bam, Kerman.

8. Mirzahoseini, H., Shahbazzadeh, D., Omumi, A., Enayati, S. Medium effect on heterologous protein leaky expression in E. coli. 1st International conference on environ. Industrial and applied microbiology (BioMicro World-2005). Bedajoz (Spain), March 15-18th 2005.

9. Scorpion envenomation in Khuzestan Province of Iran. 1st ACIP meeting Maghreb-Iran, Casablanka, 25- 26 Jan 2007.

10. The study of origin of H9N2 avian influenza outbreak in Iran. 8th Asian pacific poultry conference (APPC) science to solutions, Bangkok, 5-6 March 2007.

11. 2nd Iranian Congress of Clinical Microbiology, Shiraz, Iran, 2008 Construction of a new fusion protein vaccine against Staphylococcus aureus infections based on adhesin molecules J.Faghri, D.Shahbaz zadeh, R.Yazdani, H.Mirmohmmad Sadeghi, S.Moghim, K.Pooshang Bagheri.

12. 10th Iranian Congress of Microbiology, Ilam, Iran, 2009. Expression of a new fusion protein derived from Fibronectin binding protein A and Clumping factor A associated to Staphylococcus aureus NCTC8325 J. Faghri, D.Shahbazzadeh, R. Yazdani, H. Mirmohmmad Sadeghi, S. Moghim, K.Pooshang Bagheri

13. 3rd Iranian Proteomics Conference (3rd IPC), Tehran, Iran, 2010

Biological analysis and proteome mapping of Hemiscorpius lepturus venom Delavar Shahbazzadeh, Kamran Pooshang

Bagheri, Mohammad Hosseini Nejad, Atiyeh Ghamnak, Ana

Meyfur, Behrouz Vaziri

Supervisor on Student Thesis (MS, Ph.D)

1. Supervising MS student thesis in Sub-cloning human alpha-fetoprotein in Pichia pastoris vector (1999).

2. Supervising MS student thesis in "Expression of Human Alpha-fetoprotein in Pichia pastoris" (2000).

3. Supervising MS student thesis in "Expression of chimeric AFP gene with estrogen binding characteristic in Pichia pastoris" (2001).

4. Teaching a part of Genetic engineering course for Ph.D. students.

5. Ph.D " (hbFGF) " 76.

6. Ph.D " RAPD-PCR" 78.

7. Ph.D " PCR" 79.

8. Ph.D " gp63 ( )" 79.

9. Ph.D " PCR " 81.

10. Ph.D " Real-time PCR" .

11. Ph.D " H9N2 81-1377" 83.

12. Ph.D " RAPD-RCR" 1383.

13. Ph.D " Real-time PCR" 27 1383. .

14. Ph.D " A A NCTC8325 " 1385.

15. Ph.D " (Zataria mutiflora) (Geranium pelargonium roseum) . 85.

16. Ph.D " VP2 A . 85.

17. Ph.D " F (PPRV) " 85.

18. Ph.D " " 85.

19. Ph.D " " 85.

20. Ph.D " K78:080 " 86-1385.

21. Ph.D 86.

Supervisor on Student Thesis (MS)

1. " " 76.

2. " ( ) " 76.

3. "" 76.

4. " " 78.

5. " " 79.

6. " " 82.

7. " " 82.

8. " " 82.

9. " " .

10. " " 1383.

11. . " " 15 1383 .

12. . " " 17 1382. .

13. " " 16 1382 .

14. " " 85.

15. " " 85.

16. " MULTI PELEX PCR S rRNA 23 SEA SEB SEC " 85-86.

17. " codon usage human basic fibroblast growgh factor ". - 87-1386.

18. "" 27/11/86.

19. " () " 87-86.

20. " codon usage human basic fibroblast growth factor (hbFGF) " 87-1386.

21. . 88 89.

1. " " Ph.D 1383-84.

2. " " 84-1383.

Publications (1995 till now)

1. D. Shahbazzadeh. Estrogen binding activity of recombinant alpha-fetoprotein expressed in yeast. Hokkaido J. Medical Science 70(3): 473-483, 1995.

2. M. Saadat, D. Shahbazzadeh, Regional assignment of the Rat Alpha-fetoprotein (AFP) to chromosome 14p21-p22. Iranian Biomedical Journal, 1 (I): 59-60, 1997.

3. A. A. Shabani, D. Shahbazzadeh, R. McMaster, A. Ghadiri, F. Mahboudi. (1998). Expression of gp63 gene from Leishmania in methylotrophic yeast Pichia pastoris. International proceedings Divisio, Monduzzi Editore; 883-886.

4. Ali Akbar Shaebani, Robert W. McMaster, Delavar Shahbazzadeh, Mohsen Karimi and Fereidoun Mahboudi. Expression of Gp63 Gene from NIH Strain of Leishmania major in Pichia pastoris Iran. Biomed. J. 5 (1): 39-45, 2001.

5. V. Karimi, M. H. Bozorgmehri Fard, D. Shahbazzadeh, M. Esmaelizad, S. A. Pourbakhsh (2004) Sequence analysis and phylogenetic study of hemagglutinin gene of H9N2 subtype of avian influenza virus isolated during 1998-2002 in Iran. Iran. Biomed. J. 8(4): 167-172.

6. Mashyekhi MR, Zarghami N, Shahbazzadeh D, Rohvand F, Azizi M., Alani B, Subcloning and Expression of Human Alphafetoprotein Gene in Pichia Pastotris Yeast. Medical Journal of Tabriz University of Medical Science. (In Persian, 2004).

7. M. R. Mashayekhi, N. Zarghami, D. Shahbazzadeh, F. Rohvand, M. Azizi, B. Alani (2006) Subcloning and expression of human alpha-fetoprotein gene in Pichia pastoris. African J. Biotech. 5 (4), 321-326.

8. Soltani Banavandi, M.J. Shahhosseiny, M.H., Shahbazzadeh, D., Karimi, V., Mirzahoseini, H., Mahboudi, F., Abachi, M., and Javadi, G. (2005). Selective Amplification of prt, tyv and invA Genes by Multiplex PCR for Rapid Detection of Salmonella typhi. Iran. Biomed. J.9(3):135-138.

9. Delavar Shahbazzadeh, Najet Srairi-Abid, Wei Feng, Narendra Ram, Lamia Borchani, Michel Ronjat, Abolfazl Akbari, Isaac N. Pessah, Michel De Waard & Mohamed El Ayeb (2007) Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine- sensitive Ca2+ channels. Biochemical J. May 15, 404 (1): 89-96.

10. Karimi V, Bozorgmehrifard MH, Shahbazzadeh D, Esmaelizad M & Pourbakhsh SA (2007) The study of origin of H9N2 avian influenza outbreak in Iran. International proceedings in 8th Asian pacific poultry conference science to solutions, Bangkok, Thailand, 201-204.

11. Srairi-Abid N, Shahbazzadeh D, Chatti I, Mlayah-Bellalouna S, Mejdoub H, Borchani L, Benkhalifa R, Akbari A, El Ayeb M. (2008) Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus. FEBS J. Sep; 275(18):4641-50.

12. Delavar Shahbazzadeh, Aref Amirkhani, Navid Dinparast Djadid, Shahla Bigdeli, Abolfazl Akbari, Hamed Ahari, Hossein Amini, Rouhullah Dehghani (2009) Epidemiological and clinical survey of scorpionism in Khuzestan province, Iran (2003). Toxicon 53, 454459.

13. Ruhollah Dehghani, Navid Dinparast Djadid, Delavar

Shahbazzadeh, Shahlla Bigdelli (2009) Introducing Compsobuthus

matthiesseni (Birula, 1905) scorpion as one of the major stinging

scorpions in Khuzestan, Iran. Toxicon 54 (2009) 272275.

14. . ... . (1387) 1382. - 3.

15. Delavar Shahbazzadeh, Hamed Ahari, Narges Mohammad Rahimi, Farhad Dastmalchi, Mahdi Soltani, Mansour Fotovat, Jafar Rahmannya, Neda Khorasani (2009) The Effects of Nanosilver (Nanocid) on Survival Percentage of Rainbow Trout (Oncorhynchus mykiss). Pakistan Journal of Nutrition 8 (8): 1178-1179.

16. Jamshid Faghri, Kamran Pooshang Bagheri, Delavar Shahbaz Zadeh, Rahmatolah Yazdani, Hamid Mirmohammad Sadeghi, Sharareh Moghim (2009) Construction of a New Fusion Protein Vector Associated to Fibronectin Binding Protein A and lumping Factor A Derived from Staphylococcus aureus NCTC8325. Iranian Journal of Basic Medical Sciences, Vol. 12, No. 1, 18-24.

17. : (1389). . 68 5 273-268.

18. Somayyeh Moaddab, Hamed Ahari, Delavar Shahbazzadeh, Abbas Ali Motallebi, Amir Ali Anvar, Jafar Rahman-Nya, Mohamad Reza Shokrgozar (2011). Toxicity study of nanosilver (Nanocid) on osteoblast cancer cell line. Int. Nano Lett., 1(1): 11-16.

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Professional memberships

-Biochemical Society of Iran

-Iranian Biotechnological Society (directory member)

Language

English , Japanese.

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