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DNA Nanostructures and Patterning

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DNA Nanostructures and Patterning . Taylor Stevenson Nucleic Acid Engineering February 15 th , 2011. Agenda. Structures Origami Branched Annealing Nanotubes Alternative Materials Patterning and Application Combing Origami as Scaffold Micropatterning Nanotubes. Origami Structures. - PowerPoint PPT Presentation

Text of DNA Nanostructures and Patterning

DNA Nanostructures and Patterning

DNA Nanostructures and Patterning Taylor StevensonNucleic Acid Engineering February 15th, 2011AgendaStructures Origami Branched AnnealingNanotubesAlternative MaterialsPatterning and ApplicationCombingOrigami as ScaffoldMicropatterning Nanotubes

Origami StructuresRothemund Folding DNA to create nano-scale shapes and patterns Nature Articles (2006)Origami StructuresRothemund Folding DNA to create nano-scale shapes and patterns Nature Articles (2006)

Branched Annealing Structures

Modified from Luo et.al. Nature Letters 2006 5. Nano-Tube Structures

Chen et. al. Approaching The Limit: Can One DNA Oligonucleotide Assemble into Large Nanostructures? (2006)Other Forms of Nucleic Acid

Braasch & Corey, Chemistry and Biology (2001)Other Forms of Nucleic Acid Lin et. al. Mirror Image DNA Nanostructures forChiral Supramolecular Assemblies Nano Letters (2009)

Combing Linear DNA for Nanowires

Deng and Mao DNA-Templated Fabrication of 1DParallel and 2D Crossed MetallicNanowire Arrays Nano Letters (2003)9DNA Origami as a Scaffold

RNA/DNA hybridization assaysKe et. al. Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays Science (2008)DNA Origami as a Scaffold

Ke et. al. Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays Science (2008)DNA Origami as a Scaffold

Rinker et. al. Self-assembled DNA nanostructuresfor distance-dependent multivalentligandprotein binding Nature Letters (2008)Micropatterning Nanotubes

Lin et. al. Functional DNA Nanotube Arrays: Bottom-Up Meets Top-Down Ange Chem (2007)

2D Patterning Branched Annealing Structures15

2D Patterning Branched Annealing StructuresRigidity of monomers affects 2/3D structure.

Varying the length of red region produces different flexibilities.16

StiffnessFlexibility2D Patterning Branched Annealing Structures

StiffnessFlexibility2D Patterning Branched Annealing StructuresMicropatterning Nanotubes