1. A 40-year-old man is beginning to have symptoms of a resting
tremor, postural instability, and mask-like (expressionless)
facies. Name the antiviral drug and its mechanism of action that
could be used against this disease. (FA13 p455) (FA14 p496) (SU14
p48) (GG p614)
2. What are the symptoms of decompression sickness? (Phys
p538)
STEP 1 REVIEW COURSE Part 1, Set 34
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3. A 55-year-old alcoholic is admitted to the hospital for upper
GI bleed. A ruptured esophageal varicose is found to be the cause.
What is the preferred medical treatment for this condition? (FA13
p341) (FA14 p371) (SU14 p121)
4. A 28-year-old man is being treated with combination of
bleomycin, etoposide and cisplatin for metastatic non-seminoma
testicular cancer. The patient develops SOB during the course of
treatment. Pulmonary function testing indicates that the patient
has a restrictive lung disease. Which of the chemotherapy agents is
responsible for this restrictive lung disease? Which of the
chemotherapy agents in the above regimen work by inducing free
radicals to interfere with DNA structure? (FA13 p372) (FA14 p404)
(SU14 p290)
STEP 1 REVIEW COURSE Part 1, Set 34
Page 3 of 5
5. How does flutamide differ from finasteride in terms of
clinical use and mechanism of action? (FA13 p539) (FA14 p591) (SU14
p225)
6. A 3-day-old preterm infant delivered at 34-weeks gestational
age develops respiratory distress syndrome (RDS). What types of
pneumocytes are affected in RDS? What is the mechanism that leads
to poor O2-CO2 exchange at the gas exchange barrier in preterm
infants with RDS? What structures make up the gas exchange barrier?
How would you increase surfactant production in the pre-term
neonate? (FA13 p544, 555) (FA14 p594, 606) (SU14 p98, 103-104)
STEP 1 REVIEW COURSE Part 1, Set 34
Page 4 of 5
7. What might you observe in a patient who presents to the
emergency room with PCP intoxication? (FA13 p471) (FA14 p515) (SU14
p55)
8. Which bone is commonly fractured when a person hits something
with the knuckles of a clenched fist, causing deep pain in the
anatomical snuffbox? (SU14 p244, 385) (COA p686)
STEP 1 REVIEW COURSE Part 1, Set 34
Page 5 of 5
9. How does the mechanism of action of benzodiazepines differ
from the mechanism of action of barbiturates? What toxicities of
barbiturates can be fatal? (FA13 p452-453) (FA14 p493) (SU14
p46)
10. IFN- stimulates macrophages and inhibits T2 helper cells.
What cell type releases IFN-? (FA13 p196) (FA14 p201) (SU14
p261)
*Page references are as follows: FA13: First Aid for the USMLE
Step 1 2013 FA14: First Aid for the USMLE Step 1 2014 SU14: Step-Up
to USMLE Step 1 2014 R: Robbins and Cotran Pathologic Basis of
Disease, 8th ed. (2010) Phys: Guyton and Hall Textbook of Medical
Physiology, 12th ed. (2011) H: Harrisons Principles of Internal
Medicine, 18th ed. (2012) COA: Clinically Oriented Anatomy, 6th ed.
(2010) GG: Goodman and Gilman Pharmacological Basis of
Therapeutics, 12th ed. (2011)
