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Disparities in Colorectal Cancer Incidence, USA 1998-2003: An Updated NPCR/SEER Data Analysis. Sun Hee Rim MPH Laura Seeff MD Faruque Ahmed MD PhD Jessica King MPH Steven Coughlin PhD American Cancer Society Cancer Disparities Conference April 18-20, 2007 - PowerPoint PPT Presentation
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Disparities in Colorectal Cancer Disparities in Colorectal Cancer Incidence, USA 1998-2003:Incidence, USA 1998-2003:An Updated NPCR/SEER An Updated NPCR/SEER
Data AnalysisData AnalysisSun Hee Rim MPHSun Hee Rim MPH
Laura Seeff MDLaura Seeff MDFaruque Ahmed MD PhDFaruque Ahmed MD PhD
Jessica King MPHJessica King MPHSteven Coughlin PhDSteven Coughlin PhD
American American Cancer Society Cancer Disparities Conference Cancer Society Cancer Disparities Conference April 18-20, 2007April 18-20, 2007
Division of Cancer Prevention and Control,
Center for Disease Control and Prevention, Atlanta, Georgia
DisclaimerDisclaimer
The findings and conclusions in The findings and conclusions in this report are those of the authors this report are those of the authors and do not necessarily represent and do not necessarily represent
the views of the Center for the views of the Center for Disease Control and Prevention.Disease Control and Prevention.
Background on Colorectal CancerBackground on Colorectal Cancer
Second leading cause of cancer deaths in Second leading cause of cancer deaths in the USAthe USA
Burden of disease is high but unequal Burden of disease is high but unequal across subpopulationsacross subpopulations
Screening = prevention & early detectionScreening = prevention & early detection
5-year relative survival rate for localized 5-year relative survival rate for localized colorectal cancer is 90%colorectal cancer is 90%
Colorectal Cancer in African AmericansColorectal Cancer in African Americans
Higher CRC incidenceHigher CRC incidence
Younger average age at diagnosisYounger average age at diagnosis Higher proportion present disease at Higher proportion present disease at
age<50 yearsage<50 years
More proximal diseaseMore proximal disease
SEER dataSEER data
Current Screening GuidelinesCurrent Screening Guidelines
National GuidelinesNational Guidelines U.S. Preventive Services U.S. Preventive Services
Task ForceTask Force American Cancer Society American Cancer Society U.S. Multi-society Task U.S. Multi-society Task
Force on CRC Screening Force on CRC Screening
Recommended for all average risk persons regardless of race/ethnicity and sex
Screening Test
Frequency
FOBT (at-home) Annually, guaiac-based or immunochemical
Flexible Sigmoidoscopy
Every 5 years
Combination: FOBT & Flex Sig
FOBT annually and Flex Sig every 5 years
DCBE Every 5 years
Colonoscopy Every 10 years
Tailored Screening Guidelines?Tailored Screening Guidelines?
Should screening guidelines take into Should screening guidelines take into account burden by demographic account burden by demographic subgroups?subgroups?Suggested modification of CRC guidelines Suggested modification of CRC guidelines for African Americans by American for African Americans by American College of GastroenterologyCollege of Gastroenterology Beginning age 45 Beginning age 45 Colonoscopy rather than flexible Colonoscopy rather than flexible
sigmoidoscopysigmoidoscopy
Objective Objective
To describe the most current burden To describe the most current burden of CRC of CRC Updated, nationally representative Updated, nationally representative
NPCR/SEER cancer surveillance dataNPCR/SEER cancer surveillance data By subpopulationsBy subpopulations
Current analysisCurrent analysis African Americans compared to whites African Americans compared to whites Age 45-49 and ≥ 50 years Age 45-49 and ≥ 50 years Incidence rates by sub-site and stage Incidence rates by sub-site and stage
CDC’s National Program of Cancer Registries (NPCR) and CDC’s National Program of Cancer Registries (NPCR) and NCI’s Surveillance, Epidemiology, and End Result (SEER)NCI’s Surveillance, Epidemiology, and End Result (SEER)
Slide courtesy of Cancer Surveillance Branch, DCPC, CDChttp://apps.nccd.cdc.gov/cancercontacts/npcr/contacts.asp
MethodsMethodsIncidence rates (IR) were age-adjusted by the Incidence rates (IR) were age-adjusted by the Direct Method to the 2000 U.S. standard Direct Method to the 2000 U.S. standard populationpopulation 95% CI and p-values were calculated95% CI and p-values were calculated
Rate Ratio (RR) was defined as the ratio of the Rate Ratio (RR) was defined as the ratio of the age-adjusted incidence ratesage-adjusted incidence rates Rate Ratio = (IRRate Ratio = (IRAfrican AmericansAfrican Americans)/(IR)/(IRWhitesWhites))
Rate Difference (RD) measured the difference Rate Difference (RD) measured the difference between the rates (per 100,000 population)between the rates (per 100,000 population) Rate Difference = (IRRate Difference = (IRAfrican AmericansAfrican Americans)-(IR)-(IRWhitesWhites))
Definition of Stage & Sub-siteDefinition of Stage & Sub-site
Stage at Stage at DiagnosisDiagnosis
Early Early localized cancerslocalized cancers
LateLatemetastasized cancersmetastasized cancers
Anatomic Anatomic SubsitesSubsites
Right: Proximal colonRight: Proximal coloncecum, ascending colon, hepatic flexure, cecum, ascending colon, hepatic flexure,
transverse colon, splenic flexuretransverse colon, splenic flexure
Left: Distal colon + RectumLeft: Distal colon + RectumDistal: descending colon and sigmoid colonDistal: descending colon and sigmoid colon
Rectum: rectosigmoid junction and rectum not Rectum: rectosigmoid junction and rectum not otherwise specifiedotherwise specified
Diagram of the ColonDiagram of the ColonSplenic flexure
Hepatic Flexure
Right Colon(Proximal)
Left Colon(Distal Colon + Rectum)
Burden of DiseaseBurden of DiseaseInvasive CRC by Selected Features,Invasive CRC by Selected Features,
United States, 1998-2003United States, 1998-2003
Sex Number (%)Age-adjusted
Incidence Rates
n = 750,252 (per 100,000)
MaleMale 380,890 (51%)380,890 (51%) 63.063.0
FemaleFemale 369,362 (49%)369,362 (49%) 45.545.5
Age
< 45 yrs 31,906 (4%) 3.5
45-49 yrs 28,643 (4%) 28.1
50-64 yrs 175,990 (24%) 82.3
≥ 65 yrs 513,713 (68%) 287.8
Invasive CRC by Selected Features,Invasive CRC by Selected Features,United States, 1998-2003United States, 1998-2003
Race Number Age-adjusted
Incidence Rates
WhiteWhite 655,491 (87%)655,491 (87%) 52.452.4
African AmericansAfrican Americans 66,233 (9%)66,233 (9%) 58.058.0
Other race*Other race* 28,528 (4%)28,528 (4%) 50.550.5
Sub-site
Proximal ColonProximal Colon 316,087 (44%)316,087 (44%) 22.322.3
Distal ColonDistal Colon 191,607 (27%)191,607 (27%) 13.613.6
RectumRectum 205,941 (29%)205,941 (29%) 14.614.6
Stage
EarlyEarly 274,461 (37%)274,461 (37%) 19.419.4
LateLate 422,704 (56%)422,704 (56%) 29.929.9
UnstagedUnstaged 53,080 (7%)53,080 (7%) 3.73.7
*Other races includes American Indian/Alaska Native, Asian or Pacific Islander, and persons of unknown race.
Invasive CRC by Age and RaceInvasive CRC by Age and RaceUnited States, 1998-2003United States, 1998-2003
Age < 50 Age ≥ 50
Number
(%)
Incidence Rate (per 100,000)
Number
(%)
Incidence Rate (per 100,000)
White White 48,315 48,315
(6.4%)(6.4%)
5.75.7 607,176 607,176
(81%)(81%)
174.7174.7
African African AmericanAmerican
8,3008,300
(1.1%)(1.1%)
7.57.5 57,933 57,933
(8%)(8%)
190.0190.0
Other Other racesraces
3,6263,626
(0.5%)(0.5%)
6.26.2 23,10723,107
(3%)(3%)
166.5166.5
Total N = 750,252 malignant tumors
*Other races includes American Indian/Alaska Native, Asian or Pacific Islander, and persons of unknown race.
Incidence by Specific Age & RaceIncidence by Specific Age & Race
AgeAge 45-49 years, 45-49 years, ≥50 years≥50 years
RaceRace African Americans, WhitesAfrican Americans, Whites
Sub-siteSub-site Right (Proximal) vs. Left (Distal + Rectum)
Stage at Stage at diagnosisdiagnosis
Early vs. Late
Colorectal Cancer Incidence Rates by Age and Race USA 1998-2003
Rates are age-adjusted except when age-specified
RR=1.39*RD=10.5
RR=1.09*RD=15.3
RD is per 100,000* Indicates p<0.05
0
50
100
150
200
250
age 45-49 age ≥ 50
Age at Diagnosis (years)
Rat
e p
er 1
00,0
00
White
AfricanAmerican
Colorectal Cancer Incidence Rate Colorectal Cancer Incidence Rate by Sub-site, Age, and Race, USAby Sub-site, Age, and Race, USA
Source Data: NPCR/SEER 1998-2003
0
20
40
60
80
100
Ag
e-A
dju
ste
d R
ate
pe
r 1
00
,00
0
White
AfricanAmerican
RR=1.16*RD=12.2
RR=0.99*RD=-1.3
Right Colon Left Colon Right Colon Left Colon
Age 45-49 Age ≥ 50
RR=1.86*RD=6.4
RR=1.18*RD=3.2
RD is per 100,000* Indicates p<0.05
Colorectal Cancer Incidence Rate Colorectal Cancer Incidence Rate by Stage, Age, and Race, USAby Stage, Age, and Race, USA
Source Data: NPCR/SEER 1998-2003
0
20
40
60
80
100
120
Ag
e-A
dju
ste
d R
ate
pe
r 1
00
,00
0
White
AfricanAmerican
RR=1.22*RD=1.9
RR=1.46*RD=7.6
RR=0.95*RD=-3.4
RR=1.14*RD=14.0
Early Late Early Late
Age 45-49 Age ≥ 50
RD is per 100,000* Indicates p<0.05
SummarySummary
Higher incidence rates among African Americans Higher incidence rates among African Americans 10 to15 more cancers/100,000 population 10 to15 more cancers/100,000 population
By sub-site, overall greater burden in left colon vs. By sub-site, overall greater burden in left colon vs. right colonright colon 6 to12 more cancers/100,000 in the right (proximal) 6 to12 more cancers/100,000 in the right (proximal)
colon among African Americans ages 45-49 and colon among African Americans ages 45-49 and ≥ 50≥ 50 3 more cancers/100,000 in the left colon among African 3 more cancers/100,000 in the left colon among African
Americans age 45-49 Americans age 45-49
By stage, overall greater burden of late vs. By stage, overall greater burden of late vs. early stage early stage 8 to 14 more cancers/100,000 at late stage among 8 to 14 more cancers/100,000 at late stage among
African Americans ages 45-49 and African Americans ages 45-49 and ≥ 50≥ 50
Strengths and LimitationsStrengths and Limitations
StrengthsStrengths NPCR/SEER combined data are most recentNPCR/SEER combined data are most recent Data provides national representation Data provides national representation
LimitationsLimitations The number of cases of disease in the U.S. is The number of cases of disease in the U.S. is
actually higher actually higher Hispanics are inclusive in the race categoryHispanics are inclusive in the race category This is a cancer registry not polyp registryThis is a cancer registry not polyp registry
DiscussionDiscussionIssues to be considered:Issues to be considered: BurdenBurden
(Incidence, counts, RR and AR)(Incidence, counts, RR and AR) CostsCosts Endoscopic capacity Endoscopic capacity Risks associated with screeningRisks associated with screening Patient preferencesPatient preferences Resource allocationResource allocation Impact of early screening on population mortality Impact of early screening on population mortality There may be other considerations… There may be other considerations…
Each of these considerations will be viewed Each of these considerations will be viewed differently from the public health, clinical, and differently from the public health, clinical, and policy perspective.policy perspective.
Contact InformationContact Information
For more information please contact:For more information please contact:
Sun Hee Rim MPHSun Hee Rim MPHASPH/CDC FellowASPH/CDC FellowDivision of Cancer Prevention and ControlDivision of Cancer Prevention and ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention4770 Buford Highway NE, MS K-554770 Buford Highway NE, MS K-55Atlanta, GA 30341-3724Atlanta, GA 30341-3724(770) 488-3252 office(770) 488-3252 [email protected]@cdc.gov
http://www.cdc.gov/cancer/http://www.cdc.gov/cancer/
AcknowledgementsAcknowledgementsLaura Seeff MD, Faruque Ahmed MD PhD, Jessica King MPH, Steven Laura Seeff MD, Faruque Ahmed MD PhD, Jessica King MPH, Steven Coughlin PhD Coughlin PhD