Disorders associated with a positive test for Rheumatoid Factor

Autoimmune Disorders

RA, Primary Sjogrens, MCTD, PM/DM, Scleroderma, ANCA-Associated vasculitis, PAN, Primary Biliary Cirrhosis.

Chronic Infections

Subacture bacterial endocarditis, TB, Leprosy, Syphilis, Hep C, Hep B, Other viral infections, Parasitic Infections

Miscellaneous Conditions

Sarcoidosis, Idiopathic Pulm Fibrosis, Silicosis, Asbestosis, Malignancy, Age >65.

(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

Conditions Associated with positive ANA detected by Indirect Immunofluorescence

Rheumatic Disease

SLE, MCTD, Scleroderma, Sjogren, RA, PM/DM, Discoid Lupus.

Organ-Specific Autoimmune Disease

Autoimmune thryoid disease, autoimmune hepatitis, Primary biliary cirrhosis, Autoimmune cholangitis.

Other

Drug-induces lupus, asymptomatic drug-induced ANA, chronic infections, idiopathic pulmonary fibrosis, primary pulmonary hypertension, lymphoproliferative disorders.

(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

Selected Antinuclear Antibodies with High Sensitivity or Specificity

Conditions High Sensitivity High Specificity

SLE ANA Anti-dsDNA, Anti-Sm

Drug-Induced Lupus ANA, antihistone --

Neonatal Cutaneous Lupus Maternal anti-Ro/SS-A --

Congenital complete heart block Maternal anti-Ro/SS-A --

MCTD ANA, anti-RNP --

Primary Sjogren Anti-Ro/SS-A (75%) --

Scleroderma (limited and Difuse) ANA (>85%) Anticentromere, anti-Scl-70

High sensitivity: >95% except where noted.High specificity: >95% except where noted.

(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.