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Discovery Development and Delivery of Biopesticides for
Integrated Pest Management
Amit Vasavada
Vice President RampD Marrone Bio Innovations
Davis California
Sept 12 2016 Global Biocontrol and Biostimulants Congress
Philadelphia PA USA
Forward-Looking Statements
Page 2
Forward-Looking Statements
This presentation contains forward-looking statements that involve substantial risks and uncertainties
All statements other than statements of historical facts included in this press release regarding
strategy future operations and plans including assumptions underlying such statements are forward-
looking statements and should not be relied upon as representing the Companyrsquos views as of any
subsequent date Such forward-looking statements are based on information available to the Company
as of the date of this presentation and involve a number of risks and uncertainties some beyond the
Companys control that could cause actual results to differ materially from those anticipated by these
forward-looking statements including any difficulty in developing manufacturing marketing or selling
the Companyrsquos products any failure to maintain and further establish relationships with distributors
competition in the market for pest management products lack of understanding of bio-based pest
management products by customers and growers adverse decisions by regulatory agencies and the
impact of negative publicity and perceptions around the companyrsquos financial restatement Additional
information that could lead to material changes in the Companyrsquos performance is contained in its filings
with the SEC The Company is under no obligation to and expressly disclaims any responsibility to
update or alter forward-looking statements contained in this presentation whether as a result of new
information future events or otherwise
Marrone Bio Innovations Overview
Page 3
bull Incorporated in June 2006
bull 5 commercially available MBI products + 1 Isagro product 2 addrsquol EPA registered amp 2 submitted for EPA registration
bull 85 employees 27 in RampD
bull Library of 18000+ proprietary microorganisms screened against multiple targets
bull Wholly-owned operational fermentation facility in Bangor MI
bull Commercial sales in North America LATAM parts of MEampA early in our long term growth curve
bull Listed on NASDAQ as MBII August 2 2013
Partners Distributors
Robust Pipeline amp IP
Company Highlights
bull Pipeline products Bioherbicide Downy mildew fungicide Biofumigant Anti-transpirant
bull Many more earlier stage candidates across all categories
bull 30 issued US and 99 issued foreign patents 27 pending US and 173 pending foreign patent applications
Commercial Products
8
1
2
3 Bio-based Agricultural Product Market is the Fastest Inputs Growth Segment
4 Expanding Internationally ndash a focused growth area for MBI
5
Highlights Marrone Bio Innovations Inc
Page 4
1 7
6
6 Existing Commercial Products With Significant Addressable Markets
Only Pure-Play Public Biopesticide Company in this Disruptive Technology-Driven Market
Experienced Management Team with Successful Track Record
Valuable Library of Patents and Intellectual Property
Focused RampD Supporting Existing Products and Select Pipeline of Near-term New Products that Meet Unmet Market Needs
MBI Products Help on All the Key Drivers in Food Production
Global Food Security
Growing more
from less
Climate Change
Temperature
moisture salinity pest
extremes
Environmental Pollution
Residues leachates
Sustainability
Ecosystem services
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Forward-Looking Statements
Page 2
Forward-Looking Statements
This presentation contains forward-looking statements that involve substantial risks and uncertainties
All statements other than statements of historical facts included in this press release regarding
strategy future operations and plans including assumptions underlying such statements are forward-
looking statements and should not be relied upon as representing the Companyrsquos views as of any
subsequent date Such forward-looking statements are based on information available to the Company
as of the date of this presentation and involve a number of risks and uncertainties some beyond the
Companys control that could cause actual results to differ materially from those anticipated by these
forward-looking statements including any difficulty in developing manufacturing marketing or selling
the Companyrsquos products any failure to maintain and further establish relationships with distributors
competition in the market for pest management products lack of understanding of bio-based pest
management products by customers and growers adverse decisions by regulatory agencies and the
impact of negative publicity and perceptions around the companyrsquos financial restatement Additional
information that could lead to material changes in the Companyrsquos performance is contained in its filings
with the SEC The Company is under no obligation to and expressly disclaims any responsibility to
update or alter forward-looking statements contained in this presentation whether as a result of new
information future events or otherwise
Marrone Bio Innovations Overview
Page 3
bull Incorporated in June 2006
bull 5 commercially available MBI products + 1 Isagro product 2 addrsquol EPA registered amp 2 submitted for EPA registration
bull 85 employees 27 in RampD
bull Library of 18000+ proprietary microorganisms screened against multiple targets
bull Wholly-owned operational fermentation facility in Bangor MI
bull Commercial sales in North America LATAM parts of MEampA early in our long term growth curve
bull Listed on NASDAQ as MBII August 2 2013
Partners Distributors
Robust Pipeline amp IP
Company Highlights
bull Pipeline products Bioherbicide Downy mildew fungicide Biofumigant Anti-transpirant
bull Many more earlier stage candidates across all categories
bull 30 issued US and 99 issued foreign patents 27 pending US and 173 pending foreign patent applications
Commercial Products
8
1
2
3 Bio-based Agricultural Product Market is the Fastest Inputs Growth Segment
4 Expanding Internationally ndash a focused growth area for MBI
5
Highlights Marrone Bio Innovations Inc
Page 4
1 7
6
6 Existing Commercial Products With Significant Addressable Markets
Only Pure-Play Public Biopesticide Company in this Disruptive Technology-Driven Market
Experienced Management Team with Successful Track Record
Valuable Library of Patents and Intellectual Property
Focused RampD Supporting Existing Products and Select Pipeline of Near-term New Products that Meet Unmet Market Needs
MBI Products Help on All the Key Drivers in Food Production
Global Food Security
Growing more
from less
Climate Change
Temperature
moisture salinity pest
extremes
Environmental Pollution
Residues leachates
Sustainability
Ecosystem services
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Marrone Bio Innovations Overview
Page 3
bull Incorporated in June 2006
bull 5 commercially available MBI products + 1 Isagro product 2 addrsquol EPA registered amp 2 submitted for EPA registration
bull 85 employees 27 in RampD
bull Library of 18000+ proprietary microorganisms screened against multiple targets
bull Wholly-owned operational fermentation facility in Bangor MI
bull Commercial sales in North America LATAM parts of MEampA early in our long term growth curve
bull Listed on NASDAQ as MBII August 2 2013
Partners Distributors
Robust Pipeline amp IP
Company Highlights
bull Pipeline products Bioherbicide Downy mildew fungicide Biofumigant Anti-transpirant
bull Many more earlier stage candidates across all categories
bull 30 issued US and 99 issued foreign patents 27 pending US and 173 pending foreign patent applications
Commercial Products
8
1
2
3 Bio-based Agricultural Product Market is the Fastest Inputs Growth Segment
4 Expanding Internationally ndash a focused growth area for MBI
5
Highlights Marrone Bio Innovations Inc
Page 4
1 7
6
6 Existing Commercial Products With Significant Addressable Markets
Only Pure-Play Public Biopesticide Company in this Disruptive Technology-Driven Market
Experienced Management Team with Successful Track Record
Valuable Library of Patents and Intellectual Property
Focused RampD Supporting Existing Products and Select Pipeline of Near-term New Products that Meet Unmet Market Needs
MBI Products Help on All the Key Drivers in Food Production
Global Food Security
Growing more
from less
Climate Change
Temperature
moisture salinity pest
extremes
Environmental Pollution
Residues leachates
Sustainability
Ecosystem services
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
8
1
2
3 Bio-based Agricultural Product Market is the Fastest Inputs Growth Segment
4 Expanding Internationally ndash a focused growth area for MBI
5
Highlights Marrone Bio Innovations Inc
Page 4
1 7
6
6 Existing Commercial Products With Significant Addressable Markets
Only Pure-Play Public Biopesticide Company in this Disruptive Technology-Driven Market
Experienced Management Team with Successful Track Record
Valuable Library of Patents and Intellectual Property
Focused RampD Supporting Existing Products and Select Pipeline of Near-term New Products that Meet Unmet Market Needs
MBI Products Help on All the Key Drivers in Food Production
Global Food Security
Growing more
from less
Climate Change
Temperature
moisture salinity pest
extremes
Environmental Pollution
Residues leachates
Sustainability
Ecosystem services
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBI Products Help on All the Key Drivers in Food Production
Global Food Security
Growing more
from less
Climate Change
Temperature
moisture salinity pest
extremes
Environmental Pollution
Residues leachates
Sustainability
Ecosystem services
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Biopesticides + Conventional Crop Protection Products
Biopesticides Can Help Meet the Challenges of Sustainable Agriculture
Page 6
Meeting the Challenges of Sustainable Agriculture
1
2
3
Integrated Pest Management
Resistance Management
Harvest amp Labor Management
Residue Management
1
2
3
Additional Benefits
Increased efficacy
Higher yield
Reduced chemical load
Increase Productivity
Promote Food Quality
Minimize Impact
1
2
3
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBIrsquos primary Core Strength is Biopesticides
Biopesticides Crop Protection
Biofertilizers Crop Nutrition
Biostimulants Crop Enhancement
bull Many many companies are going into biostimulants but fewer venture into biopesticides because of the higher technical and regulatory barriers to entry
bull MBIrsquos competitive advantage is discovering and rapidly commercializing registered biopesticides many of which also have biostimulant properties
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBI finds and develops biopesticides that also are biostimulants providing both crop protection and increased plant health and yield
MBIrsquos Unique Dual-Use Approach
Plant Growth Promotion
Stress Tolerance
Pesticidal Activity
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Discovery
Page 9
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
10
Screening the Microbial Diversity
gt40 000
samples
gt18 000
isolates
Isolation Multi-target Screening
37
24
39
Bacteria
Fungi
Actinomycetes
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBI Unique Natural Product Chemistry-Focused Discovery
Samples from around the world from areas of high biodiversity are collected and cultured
Microbes are grown in liquid commercial-like media Water extracts of fermentation broths are prepared for bioassays
Biological testing against weeds insects plant pathogens nematodes algae and for growth promotion are performed Microbegenetic ID
Identify pesticidal compounds eliminate harmful strains Develop analytical assays for mfg QC
Isolation Fermentation Biological Testing Natural Product amp Analytical Chemistry
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Primary Screen Testing Progression Hundreds of early stage hits for partnering
Hit Type Total Hit Rate
()
One Hit
Perhellip
What Has Been
Screened
Herbicide - Broadleaf 305 195 51 15670
Herbicide - Grass 151 119 84 12695
Herbicide - Plant Test Grass 63 232 43 2721
Herbicide - Plant Test
Broadleaf
19 070 144 2729
Insecticide - Beet Armyworm 16 010 1002 16037
Insecticide - Lygus 8 006 1568 12547
Insecticide - Corn Rootworm 2 072 138 276
Fungicide - Botrytis 954 574 17 16620
Fungicide - Monilinia 940 565 16 16620
Nematicide 206 20 9695 9695
Algaecide 83 067 150 12419
Bactericide 74 138 73 5371
Plant Health (Corn) 108 772 13 1399
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
2007Started screening
Herbicide broadleafInsecticide BAW
Fungicide (Bot+Mon)
2012Plant health and growth promoters
2011Algaecides amp Bactericides
2009Grass Herbicides amp Lygus
2010Nematicides
A B C D FE G H I J K L M N O P Q R S
2013-2014Improvement of bioassays and refining of target Rescreening collections
Hit type Total Hit Rate () One hit perhellipWhat has been
screened
Herbicidal broadleaf 305 195 51 15670
Herbicidal grass 151 119 84 12695
Herbicidal in planta grass 63 232 43 2721
Herbicidal in planta broadleaf 19 070 144 2729
Insecticidal chewing (BAW) 16 010 1002 16037
Insecticidal sucking (Lygus) 8 006 1568 12547
Insecticidal CRW 2 072 138 276
Fungicidal Botrytis 954 574 17 16620
Fungicidal Slerotinia 5 893 11 56
Nematicidal 1 001 9695 9695
Algaecidal 83 067 150 12419
Bactericidal 74 138 73 5371
Plant Health (in planta corn) 108 772 13 1399
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBIrsquos Strength Diverse Chemistry Found
O
N
CH3H3C
H2N
O
N
O
N
H
O
OH3C
CH3H3C
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
HO
CH3
OH
OH
CH3
N CH3 HO OH
OH3C
O
O
H
OH3CCH3
O
O
CH3
OH
CH3
DISCOVERY
from a new bacterial species
HerbicidalAlgicidal
Templazole A Templazole B
Herbicidal
Templamide B
HerbicidalAlgicidalInsecticidal
Templamide A
HerbicidalInsecticidal
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Development
Page 14
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Innovative Iterative Interactive
15
bull Manufacturing bull Sales and Marketing
bull Regulatory
bull QCQA
bull Product and field Development
Microbiology amp Molecular
Technologies
Bioprocess Technologies
Analytical Chemistry
Bioassay
Innovation
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Product and Process Development Cost-effective Value-added Consistent efficacy Easy to use
Develop farmer-friendly
formulations (lab amp pilot facilities)
Develop and scale manufacturing processes (lab pilot amp mfg facilities)
Conduct field trials (4 MBI
Field Dev staff)
Develop data for the regulatory submission
(in-house team)
Goal Cost-effective Value-added Consistent efficacy Easy to use
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Case Study Grandevoreg
17
5 lb bag Fine powder with 30 active
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
18
bull Proven cross-spectrum control
ndash Chewing and sucking insects
ndash Mites
bull Naturally derived from Chromobacterium subtsugae
bull Complex modes of action
bull Easy on beneficials
Photos courtesy of Lygus Entomart Beet armyworm Clemson Univ USDA Cooperative Extension Slide Series Bugwoodorg Western flower thrip Frank Peairs CO St Univ Bugwoodorg citrus leaf miner Center for Invasive Species Research UC Riverside cabbage Looper RJ Reynolds Tobacco Company Bugwoodorg twospotted spider mite Clemson EDU
GrandevoregmdashProven InsecticideMiticide
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Microbial Biopesticide Formulations
19
Develop both liquid and dry formulae for different applications
Liquid Concentrates Spray or Freeze Dried Powder Granules
bull Strategies in formulation development
Stabilize active ingredients
Reduce application rate
Market acceptance
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
2nd Generation Formulation Development
20
Areas for Improvement
bull Dispersion of the powder
bull Dustiness and handling
bull Occasional spray nozzle clogging at lower water volumes
Tier 1 Grower preference
bull Liquid formulation
bull Wettable dispersible granules
Tier 2 Product (spray applications)
bull Easily dispersible in water
bull No dustiness no clogging
bull Equivalent active loading
Tier 3 Manufacturing and Regulatory
bull Low COGS
bull Scalability and processability
bull Suitable for Organic market
Development Approach
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
21
Approach 1 amp 2 Processing and formulation change
Wetting and Dispersion
1 Contact angle and surface tension 2 Particle size and surface property 3 Density of the powder 4 Wetting and fish eye structure
Efficacy and Stability
1 UV stability 2 Sprayable solution (sedimentation and clogging issues) 3 Spreadability
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Processed samples
22
Grandevo Processing Change Formulation change
- Grandevo (35um mean)
- Processing change (100um mean)
- Formulation change (73um mean)
- Grandevo(0979um mean)
- Processing change (12um mean)
- Formulation change(461um mean)
Dry particle size Wet particle size
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Microscopic images
Page 23
Grandevo
Formulation change
Processing Change
Zoomed pictures
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Field Trials Grandevo vs Grandevo WDG
24
Trial ID Crop Pest Outcome
15-018BMS-FL Tomato Whitefly Equivalent in control
15-019BMS-FL Tomato Whitefly Equivalent in control
15-020BMS-FL Tomato Whitefly Equivalent in control
15-022BMS-FL Tomato Whitefly Equivalent in control
15-043MJO-CA Lettuce Western flower thrip Equivalent in control
15-027NWV-WA Cane berry SWD Equivalent in control
15-028NWV-WA Cane berry SWD Equivalent in control
15-045MJO-CA Cane berry SWD Equivalent in control
15-030TBJ-MI Cherry SWD Equivalent in control
15-038MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-039MJO-CA Grape Lepidoptera-OLR Equivalent in control
15-026NWV-WA Grape Mites Equivalent in control
22 Field trials 12 shown below 4 had no pest pressure and 6 showed
poor control for both formulations
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Pilot scale up
Extruder
Dome Extrusion Radial Extrusion Basket Extrusion
The formulation was processed through different extrusion equipment with varying
shearcompaction and processing variables to test robustness
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Timeline
26
Proof of concept to launch of product 20 months
bull Formulation and process development 9 months
bull Scale up of the WDG and DF formulations 6 months
bull Scale up effort was performed at 6 different facilities
bull Manufacturing start date Month 15th
bull Packaging and labeling was designed in house
bull Field testing 2 seasons
bull EPA registration 7+ months
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Delivery
Page 27
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
28
Grandevo WDG Development
Grandevo
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Highlights
Broad spectrum protection thatrsquos easy on beneficials hellip including honey bees
Help ensure quality and can enhance yields
Safe for workers
Environmentally friendly
Can be used in organic or conventional production greenhouses and field
Reduce use of synthetic chemicals
No residues or required spray buffer zone
Minimize risk of resistance
MRL tolerance exemption exempt from CODEX
Naturally derived produced via clean fermentation and extraction processes
Our Bio-based Products are Ideal Additions to Integrated Pest Management Programs
Page 29
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Near-term Pipeline is Targeting Key Unmet Needs
30
MBI-110 Biofungicide (Discovered in MBIrsquos screen) bull Controls difficult plant diseases such as white mold amp downy mildews where there
are fewer chemical and biological alternatives
MBI-010 Bioherbicide (New species of bacteria produces systemic compounds) bull Controls glyphosate-resistant and other herbicide-resistant weeds bull Addresses the 1 need of organic farmers ndash weed control bull Novel mode of action (No new herbicide modes of action in ~25 years)
MBI-601 Biofumigant (Novel genus and species of volatile gas-producing fungus) bull Alternative for toxic methyl bromide and other chemical fumigants that are heavily
restricted or being phased out bull Could be deployed for post harvest control on fruits and grains
MBI-505 Anti-transpirant (extracted fatty alcohol compounds from coconut oil) bull Reduces water loss reflects heat to reduce crop stress and increase yield
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
MBIrsquos Products and Pipeline MBIrsquos current RampD is primarily focused on supporting existing commercial products
Page 31
Insecticide
Pre-Development Development Regulatory Natrsquol Launch Discovery
Insecticidemiticide
Fungicide (powdery mildewbroad spectrum plant health) 2011
2013
Nematicide
Herbicide (burndown) MBI 011
MBI 303
EPA approved
Ne
ar-t
erm
Pip
elin
e
Co
mm
erc
ial
Pip
elin
e
Anti-transpirant State registrations only
2015
2014
Herbicide Submit to EPA 2016 MBI 010
Nematicide MBI 302
Nematicide
MBI-005
Aquatic molluscicide for invasive mussels 2013
2013
EPA approved
Nematicideinsecticide
Intern
al D
evelop
men
t Seekin
g develo
pm
ent amp
m
arketing p
artners
Biostimulant (yield and stress) MBI 506
2016
Herbicide (pre- and post emergence)
MBI-304
EPA approved (needs cost reduction)
EPA approved (needs mfg partner)
Biofumigant MBI 601 Pending EPA approval
Biostimulant (yield and stress) Market-ready State registrations only
MBI 5078
Fungicide (downy mildewwhite mold) Pending EPA approval MBI 110
EPA package largely developed
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
Our Products Are Used Across All Production Systems and IPM Programs
2) No Residues For Export 3) Conventional
In the tank with chemicals to enhance control reduce resistance
Early sprays and last spray before harvest
Rotated with a limited of bioinsecticides amp to
each other
For organic production
1) Organic
reg
32
4-hour REI
0-day PHI
Tolerance
Exempt
Complex
Modes
of Action
Reduces
Chemical
Impact
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
33
Thank You wwwmarronebioinnovationscom
530-750-2800 Infomarronebiocom
![Lecture-Biopesticides [Compatibility Mode].pdf](https://img.pdfslide.us/doc/110x75/577cc31d1a28aba711952b43/lecture-biopesticides-compatibility-modepdf.jpg)
