Directory of Cyclotrons used for Radionuclide Production in Member

IAEA-DCRP/2006

Directory of Cyclotrons used for Radionuclide Production in

Member States 2006 Update

October 2006

The originating Section of this publication in the IAEA was:

Industrial Applications and Chemistry Section International Atomic Energy Agency

Wagramer Strasse 5 P.O. Box 100

A-1400 Vienna, Austria

DIRECTORY OF CYCLOTRONS USED FOR RADIONUCLIDE PRODUCTION IN MEMBER STATES:

2006 UPDATE IAEA, VIENNA, 2006

IAEA-DCRP/2006 ISBN 92-0-111506-7

© IAEA, 2006

Printed by the IAEA in Austria October 2006

FOREWORD

The present directory of cyclotron facilities used for the production of radionuclides in Member

States is an update of the one compiled by the International Atomic Energy Agency (IAEA) in late 2001 and published in 2002. This directory was prepared through information collected by questionnaires that the IAEA sent to known institutions operating cyclotrons for radionuclide production. Technical as well as administrative data supplied to the IAEA as of November 2005 were taken into account.

The directory is considered to include most of the cyclotrons of the world that are used at least

partially for radionuclide production. There are 262 entries for cyclotrons operating in 39 Member States of the IAEA. This is an increase of 7% over the 246 reported in the 2002 cyclotron directory. This can be compared to the 350 or so cyclotrons believed to be presently operating in the world, which are involved in some aspects of radionuclide production. The increase has been in the number of cyclotrons in developed countries, but even more so in the developing countries. The increase in number during the last four years was driven by several factors, i.e. advent of advances in medical imaging, introduction of compact, user friendly medical cyclotron, and a recent decision that costs for 15O-oxygen position emission tomography (PET) studies in Japan and 18F-FDG PET studies in Germany and the United States of America are eligible for reimbursement by government or health insurance companies. There is no doubt that the fastest growing segment of the market is in the commercial distribution of FDG to local hospitals.

The IAEA is promoting cyclotron technology as applied to nuclear medicine. Requests for

cyclotron technology is steadily increasing; many developing Member States are interested in this technology. There is need to stimulate, build and maintain consulting capability in interested developing Member States. There are good reasons to believe that the number of cyclotron facilities dedicated to the production of PET tracers will continue to grow in the near future, so the need to further update the directory will be assessed in due course, depending on comments and suggestions receiving from users of the directory. This directory will help decision makers and specialists in Member States to draft mid and long term strategies regarding the implementation of cyclotron technology for radioisotope production and their medical applications, as well as for selection of the most suitable alternative.

The IAEA wishes to thank D.J. Schlyer of the Brookhaven National Laboratories, USA, for his

analysis of the data. The IAEA officer responsible for the compilation of the directory was M. Haji-Saeid of the Division of Physical and Chemical Sciences.

EDITORIAL NOTE

This CD-ROM has been prepared from the original material as submitted by contributors. Neither the IAEA nor its Member States assume any responsibility for the information contained on this CD-ROM. The use of particular designations of countries or territories does not imply any judgement by the publisher, the IAEA, as to the legal status of such countries or territories, of their authorities and institutions or of the delimitation of their boundaries. The mention of names of specific companies or products (whether or not indicated as registered) does not imply any intention to infringe proprietary rights, nor should it be construed as an endorsement or recommendation on the part of the IAEA.

CONTENTS

SUMMARY ............................................................................................................................................ 1 1. Argentina......................................................................................................................................... 7 2. Australia........................................................................................................................................ 11 3. Austria........................................................................................................................................... 17 4. Belgium......................................................................................................................................... 21 5. Brazil............................................................................................................................................. 37 6. Canada........................................................................................................................................... 41 7. China............................................................................................................................................. 59 8. Czech Republic ............................................................................................................................. 77 9. Denmark........................................................................................................................................ 81 10. Egypt ........................................................................................................................................... 85 11. Finland ........................................................................................................................................ 87 12. France.......................................................................................................................................... 95 13. Germany.................................................................................................................................... 107 14. Hungary..................................................................................................................................... 153 15. India .......................................................................................................................................... 155 16. Indonesia ................................................................................................................................... 159 17. Iran, Islamic Republic of........................................................................................................... 161 18. Israel.......................................................................................................................................... 163 19. Italy ........................................................................................................................................... 167 20. Japan ......................................................................................................................................... 193 21. Kazakhstan................................................................................................................................ 265 22. Korea, Republic of .................................................................................................................... 267 23. Mexico ...................................................................................................................................... 297 24. Netherlands ............................................................................................................................... 299 25. Norway...................................................................................................................................... 319 26. Philippines................................................................................................................................. 321 27. Poland ....................................................................................................................................... 323 28. Romania .................................................................................................................................... 327 29. Russian Federation.................................................................................................................... 329 30. Saudi Arabia.............................................................................................................................. 347 31. Slovakia..................................................................................................................................... 349 32. South Africa .............................................................................................................................. 351 33. Spain ......................................................................................................................................... 353 34. Sweden...................................................................................................................................... 363 35. Switzerland ............................................................................................................................... 365 36. Syrian Arab Republic................................................................................................................ 371 37. Turkey ....................................................................................................................................... 373 38. United Kingdom........................................................................................................................ 377 39. United States of America .......................................................................................................... 391

SUMMARY

The directory of cyclotrons used for radionuclide production in Member States contains

technical, utilization and administrative information supplied to the IAEA as of November 2005. It was prepared through information collected by questionnaires sent to institutions that either have a cyclotron or were identified to be in the process of installing a cyclotron.

Included in the directory are a significant fraction of the cyclotrons of the world that are used at

least in part for radionuclide production. If replies were not received from institutions, it was assumed that the cyclotron is still being used for similar tasks as it was at the time of the last survey. Some institutions reported that older cyclotrons had been shut down and replaced with newer cyclotrons. The questionnaire was, in general, not completed by institutions that have cyclotrons dedicated to physics and/or material science activities. Certain of the institutions constructing superconducting cyclotrons for medical and nuclear physics applications responded even though they are not yet involved in radionuclide production initiatives.

The directory is organized alphabetically by Member States and by institutes. There are

individual entries for each cyclotron even for institutions having more than one cyclotron. The names, title/position of the persons listed in position in the entries for individual countries were taken directly from the answers in the questionnaires.

There are 262 entries for cyclotrons operating in 39 Member States of the IAEA. This is an

increase of 7% over the 246 reported in the 2002 cyclotron directory. This can be compared to the 350 or so cyclotrons believed to be presently operating in the world, which are involved in some aspects of radionuclide production. The increase has been in the number of cyclotrons in developed countries, but even more so in the developing countries. Large concentrations of cyclotrons for radionuclide production are located in the United States of America, Japan and Germany. The largest number of cyclotrons for a single country is in the United States of America. However, taken collectively there are more cyclotrons located in the European Union countries that are used for medical radionuclide production.

The number of institutions which distribute radiopharmaceuticals and 18F-FDG, in particular, is

significant and growing. In this sample, 75% of the cyclotrons are being used to produce FDG, either for internal use or for distribution. This is certainly an underestimate as the commercial suppliers are under represented in this survey.

The expansion in the number of cyclotrons during the last 10 years has been driven by the

advent of advances in medical imaging instrumentation (PET, SPECT and more recently PET/CT); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that some PET radiopharmaceuticals are eligible for reimbursement by government or insurance companies. There is no doubt that the fastest growing segment of the market is in the commercial distribution of 18F-FDG to local hospitals. Many centers have begun distributing FDG and at present at least 36% of the centers producing FDG are distributing it. Again this is a lower limit rather than an accurate assessment. The satellite approach is cost-effective because it is not necessary for every medical imaging centre to own a cyclotron as a source of short-lived radiopharmaceuticals. 18F-FDG is gaining widespread clinical acceptance for a variety of disease states.

The number of types of cyclotrons available commercially is quite large and growing. The energies range from a few MeV for only PET isotope production to a few hundreds MeV for proton therapy or production of radioisotopes requiring these high energies. The beam currents range upwards from 40 µ to over 1 mA. The characteristics of the machines available for commercial acquisition are shown in Table I.

1

TABLE I. CHARACTERISTICS OF COMMERCIAL CYCLOTRONS

Company Model Description Oper. Plan CTI, Inc. RDS 111 11 MeV H-, 60µA 44 10 RDS 112 11 MeV H-, 60µA 30 Ebco Technologies TR 14 11-14 MeV H-, 100µA 2 TR 19 14-19 MeV H-, 160µA 2 TR 19/9 19 MeV H-, 9 MeV D-, 160µA 1 3 TR30 30 MeV H-, 100µA 2 TR30/15 30 MeV H-, 15 MeV D-, 160µA 1 D.V. Efremov Institute MGC-20 18 MeV H-, 10 MeV D-, 160µA 4 2 General Electric MiniTrace 9.6 MeV H-, 50µA 2 PETrace 16.5 MeV H-, 8.6 MeV D-, 80µA 16 Ion Beam Applications Cyclone 3 3.8 MeV D-, 60µA 2 Cyclone 10/5 10 MeV H-, 5 MeV D-, 60µA 3 Cyclone 18/9 18 MeV H-, 9 MeV D-, 80µA 15 5 Cyclone 18+ 18 MeV H-, 80µA 1 Cyclone 30 30 MeV H-, 15 MeV D-, 400µA 16 2 Cyclone 235 240 MeV H- 1 Japan Steel Works BC168 16 MeV H+, 8 MeV D+, 50µA 2 BC1710 17 MeV H+, 10 MeV D+, 60µA 7 BC2010N 20 MeV H-, 10 MeV D-, 60µA 2 BC2211 22 MeV H+, 11 MeV D+, 60µA 1 BC3015 30 MeV H+, 15 MeV D+, 60µA 1 Oxford Instrument Co. OSCAR 12 12 MeV H-, 60µA 5 Scanditronix Medical AB MC17 17.2 MeV H+, 8.3 MeV D+, 60µA 13 12 MeV 3He++, 16.5 4He++, 60µA MC30 30 MeV H+, 15 MeV D+, 60µA MC32NI 15-32 MeV H-, 8-16 MeV D-, 60µA 3 11-23 MeV 3He++, 15-31 4He++, 60µA MC40 10-40 MeV H+, 5-20 MeV D+, 60µA 6 13-53 MeV 3He++, 10-40 4He++, 60µA MC50 18-52 MeV H+, 9-25 MeV D+, 60µA 1 24-67 MeV 3He++, 18-50 4He++, 60µA MC60 50 MeV H+, 60µA 1 K130 6-90 MeV H-, 10-65 MeV D-, 60µA 16-173 MeV 3He++, 20-130 4He++ Sumitomo Heavy Industries CYPRIS 325 16 MeV H+, 8 MeV D+, 60µA 1 CYPRIS 370 16 MeV H+, 10 MeV D+, 60µA 4 HM 18 18 MeV H-, 10 MeV D-, 60µA 7 HM 12 12 MeV H-, 6 MeV D-, 60µA 1 480 AVF 30 MeV H+, 60µA 1 AVF 680 40 MeV H+, 60µA 1 AVF 715 50 MeV H+, 60µA AVF 750 70 MeV H+, 60µA 1 AVF 930 90 MeV H+, 60µA 2 AVF 1000 80 MeV H+, 60µA Ring Cyclotron 400 400 MeV H+ (K=400), 60µA 1 Ring Cyclotron 540 240 MeV H+ (K=540), 60µA 1 C235 240 MeV H-, 60µA 1 KIRAMS Kirams-13 13 MeV H+, 100 µA 3

2

Of the respondents to the survey, the number of existing cyclotrons broken down by energy

level is given in Fig. 1.

0

20

40

60

80

100

120

140

160

180

<10 MeV 10-20 MeV 20-30 MeV 30-40 MeV 40-100 MeV >100 MeV

Energy Distribution

Number of Cyclotrons

FIG. 1. Distribution of proton energies as reported by respondents to the IAEA survey.

The preponderance of low energy cyclotrons can be clearly seen from the distribution which is very similar to the distribution from the 2002 edition of the directory. Another interesting aspect is the distribution of time being devoted to radioisotope production. This distribution is shown in Figure 2.

0

10

20

30

40

50

60

70

80

<5 hrs 5-15 hrs 15-25 hrs 25-35 hrs 35-100 hrs >100 hrs

Radioisotope Production Hours per week

Number of Instutions

FIG. 2. Distribution of hours of radioisotope production from the respondents to the IAEA survey.

3

One interesting aspect of this distribution is that many institutions are spending a very small

fraction of the available time in radioisotope production. The cyclotron is idle for a significant fraction of the week. This implies that the cyclotron is not the slow step in clinical applications and that a single cyclotron can support several PET or PET/CT cameras.

The other interesting trend is in the compounds that are being synthesized with these

radioisotopes. A graph of the number of centres that responded synthesizing these compounds is given in Fig. 3.

0

50

100

150

200

250

FDG FLT FDOPA Methonine Ammonia Water

Compound

Number of Instutions

FIG. 3. Number of reporting institutions that use a particular compound.

This figure clearly shows that 18F-FDG is the most widely produced compound at cyclotron facilities world wide. It is now used in many applications in diagnostic nuclear medicine.

TABLE II. EXPECTED PRODUCTION YIELDS (MCI) OF SYNTHETIC PRECURSORS OF PET RADIOPHARMACEUTICALS WITH SELECTED PROTON AND DEUTERON ENERGIES AND IRRADIATION AT 20 TO 35 ΜA AS RECOMMENDED BY THE MANUFACTURER OF VARIOUS CYCLOTRONS.

Precursor 12 MeV p only 10 MeV p + 5 MeV d 18 MeV p + 9 MeV d 11CO2 1500 1000 2800 11CO 1000 350 1400 11CO 1250 350 700 11CO 750 250 1200 13NH3 200 100 450 15O2 1000 >150/min. 1200 15OC 500 >75/min. 700 15OCO 500 >150/min. 700 15OH2 750 200 1000 18F- 700 >500 800 18FF 300

4

One of the areas of current research is on the development of very high current targets that can

produce several curies of fluorine-18 for synthesis of 18F-FDG. This type of target is advantageous for production facilities where distribution of 18F-FDG is being carried out on a routine basis.

5

1

1. ARGENTINA

2005 COUNTRY: ARGENTINA ARG-1

[1] INSTITUTE: Comisión Nacional de Energia Atómica (CNEA) Avenida del Libertador 8250 1429 Buenos Aires

TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:

+54 11 4379 8250 [email protected] +54 11 4480 0615

[2] PERSON IN CHARGE: POSITION:

Mr. Carmelo Rocco Head of the Facility

OTHER SENIOR STAFF: NAME/POSITION

Mr. Ortega Daniel, in charge of Operation and Maintenance Mr. Guevara Ernesto, in charge of Radiochemistry

[3] TYPE OF

CYCLOTRON: Isochronous, negative ion

YEAR OF: (I) INSTALLATION:

1994

MANUFACTURER: The Cyclotron Corporation

(II) UPGRADE: Beam current increase

MODEL: CP - 42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 25/42 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

29 22 - 7 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:

Materials science: Proton therapy:

Physics: Neutron therapy:

Activation analysis: Other (specify)

[7] IS THE CYCLOTRON USED TO PRODUCE:

Calibration sources? (specify which & quantity) Yes No

Mössbauer sources? (specify which & quantity) Yes No

X ray sources? (specify which & quantity) Yes No

Intense neutron beam? (specify average En = ?) Yes No

[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 123I, 123I iodide and other compounds, 67Ga, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s and how often? Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?

Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number

511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

7

2

18F RADIONUCLIDE PRODUCTION Production Typical

production

yield (GBq)

% Isotopic

enrichment 18

O used

Target Volume Usage/year Do you

recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 25 95 1.7 45 Yes No

20Ne (d, α) 18F 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production

Used on site Distribution/

Sales

Price/

GBq 18FDG 15 4 weekly Yes No Yes No U$S 392 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price

/GBq

Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield

on batch, GBq

Frequency of

production

Nuclear reaction used Distribution/

Sales

Price/

GBq

Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on batch

(GBq)

Frequency of production Nuclear reaction

used

Price/

GBq

OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 37 2 monthly Yes No Yes No US$ 324 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being

produced) The production of high purity 123I is a project that was carried out under the IAEA’s Technical Co-operation Programme (ARG/4/085). The IAEA supported the CNEA efforts to set up required facilities including different system provision of expert and personnel training.

8

3

2005 COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina Nuclear

Garibaldi 405, CP 5500 Mendoza 1429


+54 261 4201 615 (1ext. 564; 2ext. 562; 3 ext. 508) [email protected] +54 261 4203 288


Ing. Enrique R. Noya Electronic Engineer – Head of Operation and Maintenance


Dr. Fernando Spigatin2, Head of Radiochemical Laboratory Ing. Norma Acosta3, Head of Radiological Security

[3] TYPE OF

CYCLOTRON: Negative ion hospital cyclotron

YEAR OF: (I) INSTALLATION

1997

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:

This cyclotron is not self-shielded. This is installed inside a bunker. All the support equipment is located in different rooms.

1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

10 8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 15O, 11C [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No


Yes No


511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



9

4


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 >97 0.330 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production

Used on site Distribution/sales Price/

GBq 18FDG 10 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 6/week p+ H20 Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on batch (GBq) Frequency of production Nuclear reaction

used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

10

5

2. AUSTRALIA

2005 COUNTRY: AUSTRALIA AUL-1 [1] INSTITUTE: Austin and Repatriation Medical Centre

Studley Road, Heidelberg, VIC 3084 TELEPHONE NO.:

E-MAIL ADDRESS: FAX NO.:

+61 3 9496 3995 [email protected] +61 3 9496 5892


Dr. Henri Tochon-Danguy Senior Radiochemist

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION

Dr. John Sachinidis, Radiochemist Dr. Uwe Ackermann, Radiochemist Mr. Stan Poniger, Cyclotron/Robotic Engineer

[3] TYPE OF

CYCLOTRON: Negative ion accelerator


1992

MANUFACTURER: IBA, s.a. (II) UPGRADE: 1996 (new sources) MODEL: Cyclone 10/5 2001 (remote start-up &

control) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 50 20 Typical beam employed (µA) 25 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 124I, [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



11

6


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 90 1 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 18FDG 24 7/week Yes No Yes No 18F MISO 2 1/week Yes No Yes No 18FLT 2 2/month Yes No Yes No

18FA85380 2 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq

PIB 2 2/week Yes No Yes No SCH23390 2 1/month Yes No Yes No Ro151788 2 2/month Yes No Yes No Choline 2 2/month Yes No Yes No PK11195 2 2/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


Sales

Price/

GBq

Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 1/min 1/week 14N[d, n] 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/


12

7

2005 COUNTRY: AUSTRALIA AUL-2

[1] INSTITUTE: Australian Nuclear Science & Technology Organization (ANSTO) Radiopharmaceutical Division New Illawarra Road


+61 2 9717 9079 [email protected]


Dr. S. Carr Director, Radiopharmaceuticals


D. Arnott

[3] TYPE OF

CYCLOTRON: Negative ion YEAR OF:

(I) INSTALLATION 1991

MANUFACTURER: IBA, s.a. (II) UPGRADE: 1997 MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



13

8


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Y No


(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


Sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/


14

9

2005 COUNTRY: AUSTRALIA AUL-3 [1] INSTITUTE: Peter MacCallum Cancer Institute

12 Cathedral Place East Melbourne 3002, Victoria


+61 3 9656 1852 [email protected] +61 3 9656 1826


Dr. Rodney J. Hicks Associate Professor/Director, PET Centre


Mr. Peter Eu, Radiochemist

[3] TYPE OF

CYCLOTRON: Superconducting YEAR OF: (I)

INSTALLATION 1998

MANUFACTURER: Oxford (II) UPGRADE: MODEL: 12 MeV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes N Maximum beam available (µA) 80 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

13 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F-AZA, 18F-LT [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F, Wesley Private Hospital/ 2-3 times/week

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 2 – Small animal 1 (Jan. 2002 delivery) – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



15

10


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 55 95 5 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 6.5 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


16

11

3. AUSTRIA

2005 COUNTRY: AUSTRIA AUS-1

[1] INSTITUTE: ARGOS Zyklotron Betriebs-Ges.m.b.H. LKH Klagenfurt, PET-Zentrum NMSE St. Veiter Str. 47, A-9026 Klagenfurt


+43 (0) 463 500 705 +43 (0) 463 500 705 14


Dr. Dirk W. Becker


Dipl. Ing. Mustafa Skenderi, QC Stefan Weber, Leading Technician

[3] TYPE OF

CYCLOTRON: PT YEAR OF:


MANUFACTURER: GE Medical Systems (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes N Maximum beam available (µA) 75 60 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

32 30 1 1 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) Isotope

production






[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): (18F) FLT, 124I, 86Y [9] Do you supply radionuclides to other institutions?



Yes No





17

12


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 120 95-96 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 65 Yes No Yes No DOPA 10 Yes No Yes No MISO 30 Yes No Yes No Fluoride 150 Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionin Yes No Yes No Cholin Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price

/GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


18

13

2005 COUNTRY: AUSTRIA AUS-2 [1] INSTITUTE: Österreichisches Forschungszentrum Seibersdorf

Department of Radiopharmaka A-2444 Seibersdorf


+43 0 50 550 3470 [email protected] +43 0 50 550 3473


Dr. Peter Angelberger Department Head


Dr. Herbert Kvaternik, Deputy

[3] TYPE OF



MANUFACTURER: GE Uppsala (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes N Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Further 18F radiopharmaceuticals [9] Do you supply radionuclides to other institutions?



Yes No





19

14


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 130 95 250 Yes No

20Ne (d, α) 18F 20 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 65 5/week Yes No Yes No FDOPA 2 2/month Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


20

15

4. BELGIUM

2005 COUNTRY BELGIUM BEL 1 [1] INSTITUTE: ULB/Erasme hospital

808 Lennik street, B-1070 Brussel TELEPHONE NO.:


00.32.2.555.47.10 [email protected] 00.32.2.555.47.01

[2] PERSON IN CHARGE: TITLE/POSITION:

Dr. S.Goldman Doctor in medicine


M.Monclus (PhD, radiochemist) M.Kadiata (PhD, radiochemist) J.Van Naemen (cyclotron engineer)

[3] TYPE OFCYCLOTRON: MANUFACTURER: MODEL:

Negative ion IBA Cyclone-30

YEAR OF: (I) INSTALLATION: (II) UPGRADE:

1990 1999-2006

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 30 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radio. product

Hours/week for research Hours/week for

maintenance

Hours/week for

applications

20 3 2.5 1 0 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 20 Radiography: 0

Materials science: 0 Proton therapy: 0

Physics: 0 Neutron therapy: 0

Activation analysis: 0 Other (specify)






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F labeled amino acid and derivatives [9] Do you supply radionuclides to other institutions?



Yes No

[11] Type of imaging equipment available on-site Number of

511 KeV coincidence 0 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 - Clinical 2 - Small animal 0 - Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research?

Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

21

16


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 111 95 1.5 ml 600 Yes No

Ne (d, α) 18F

16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 67 254/year Yes No Yes No 18F MPPF 2 10/year Yes No Yes No 18F F- 2 5/year Yes No Yes No 18F phenylalanine

2 5/year Yes No Yes No

18F FET 2 10/year Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C methionine 8 154 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N radiopharmaceuticals produced Name (list)

Typical yield on batch (GBq)

Frequency of production

Nuclear reaction used Distribution/ sales

Price/ GBq

13N NH3 3 10 16O(p,α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq 15O H2O 3 10/year 16O(p,pn)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 0 Yes No Yes No 67Ga 0 Yes No Yes No 86Y 0 Yes No Yes No 94mTc 0 Yes No Yes No 103Pd 0 Yes No Yes No 111In 0 Yes No Yes No 123I 0 Yes No Yes No 124I 0 Yes No Yes No 201Tl 0 Yes No Yes No 211At 0 Yes No Yes No

22

17

2005 Country: BELGIUM BEL-2 [1] Institute: Institute of Nuclear Sciences

University of Ghent Proeftuinstraat 86, B-9000 Gent

Telephone no.: E-mail address: Fax No.:

+32 9 264 6616 [email protected] +32 9 264 6699

[2] Person in charge: Position:

Professor Dr. Karel Strijckmans Professor

Other senior staff: Name/Position

[3] Type of cyclotron: Isochronous Year of: (i) installation 1977 Manufacturer: CGR-MeV (France) (ii) upgrade: 1982 Model: 520 [4] Cyclotron characteristics: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 2.5 – 24 3 – 14.5 6 – 32 10 – 29 Yes No Maximum beam available (µA) 100 100 60 60 Typical beam employed (µA) 20 5 - - [5] Cyclotron operation: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-30 10 10-20 <1 [6] Cyclotron applications: h/week h/week

Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: <1 Activation analysis: <1 Other (specify) PIXE 10-20 [7] Is the cyclotron used to produce: Calibration sources? (specify which & quantity) Yes No Tracers 1

207Bi 0.4 MBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En = 7MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] Type of imaging equipment available on-site Number

511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



23

18

18F Radionuclide production Production Typical

production

yield (GBq)

% Isotopic

enrichment

18O used

Target Volume Usage/year Do you recycle

18OH2?

18OH2 (ml)

18O2 (ml)

18OH2 (g)

18O2 (l)

18O (p, n) 18F 15 97 0.8 50 Yes No

20Ne (d, α) 18F 16O (α, d) 18F 18F radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 4 3-4/week Yes No Yes No seronotin receptor antagonist

Yes No Yes No

Yes No Yes No Yes No Yes No 11C radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

PK 11195 4 <1/week Yes No Yes No CAMPRAL 4 <2/week Yes No Yes No new research molecules

Yes No Yes No

Yes No Yes No 13N radiopharmaceuticals produced Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Yes No 15O radiopharmaceuticals produced Name

(list)

Typical yield on line

(GBq)


used

Price/

GBq

O2 4 GBq min-1 <1/week 14N(d, n) 15O CO2 4 GBq min-1 <1/week 14N(d, n) 15O CO 2 GBq min-1 <1/week 14N(d, n) 15O Other isotopes produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBql 81Rb 81mKr 0.6 2/week Yes No Yes No 48V <1/week Yes No Yes No 114In <1/week Yes No Yes No 75Se <1/week Yes No Yes No 74As <1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No Comments: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

24

19

2005 COUNTRY: BELGIUM BEL-3

[1] INSTITUTE: MDS Nordion S.A. Zone Industrielle B-6220 Fleurus


+32 10 829 211 +32 10 829 696


Dr. Claude Pirarat Manager, Radiochemical Production


[3] TYPE OF

CYCLOTRON: Isochronous Cyclotron H-


1992

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 - 30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 400 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions? If yes and available, name of

institution/s & how often? Bulk 201Tl – Europe, North and South America, 123I, 201Tl – Europe (OEM manufacturing)

Yes No


Yes No





25

20


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No 123I 100 – 250 4/week Yes No Yes No 201Tl 150 - 300 5/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


26

21

- 2005 COUNTRY: BELGIUM BEL-4

[1] INSTITUTE: Universite catholique de Louvain Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar – Head of Radiochemistry

[3] TYPE OF

CYCLOTRON: Compact H- YEAR OF: (I)

INSTALLATION 1987

MANUFACTURER: UCL/IBA, s.a. (II) UPGRADE: MODEL: Prototype

Cyclone 30

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 – 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 50/300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

30 - 4 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:


Physics: 15 Neutron therapy:










Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



27

22


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 80 95 2 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG 40 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 5 monthly Yes No Yes No Methionine 5 weekly Yes No Yes No Flumazenil 5 monthly Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NH4OH 5 weekly 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 10 2/week 16O (p, pn)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 weekly Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

28

23


[1] INSTITUTE: Universite catholique de Louvain Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar – Head of Radiochemistry

[3] TYPE OF

CYCLOTRON: Isochronous multiparticle variable energy

YEAR OF: (I)

INSTALLATION 1969-1972

MANUFACTURER: Thomson – CSF. (II) UPGRADE: MODEL: Cyclone [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 – 85 10 – 55 15 – 145 20 - 110 Yes No

Maximum beam available (µA) 30 20 5 20 Typical beam employed (µA) 20 10 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? To two centres, sporadically. Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



29

24


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 28Mg 20 MBq Al (100%) Yes No Yes No 52Fe 0,2 – 2 MBq Mn (100%) Yes No Yes No 94,95,96Tc 0,1 – 0,01 MBq Mo (nat) Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

30

25


[1] INSTITUTE: Universite de Liege Centre de Recherches du Cyclotron Sart Tilman, B-4000 Liege


+32 4 366 2360 [email protected] +32 4 366 2946


Dr. A. Luxen Director


C. Brihaye, Senior Radiochemist G. Del Fiore, Senor Radiochemist C. Lemaire, Senior Radiochemist A. Plenevaux, Senior Radiochemist, Aerts/Pharmacist

[3] TYPE OF

CYCLOTRON: H-/D- YEAR OF:


MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 35 Typical beam employed (µA) 50 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) PET/30






[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Several radiopharmaceuticals specific for receptoe and gene expression imaging. [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 –Clinical 2 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No

[14] Is the cyclotron used for targetry development? Yes No

[15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No

[16] Does your institute accept IAEA research fellows for training/experience? Yes No

31

26


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 4 Ci 95 2 Yes

No 20Ne (d, α) 18F 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 75 250/year Yes No Yes No FTyrosine 11 12/year Yes No Yes No FDopa 11 12/year Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 0.37 4000/year OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


32

27


[1] INSTITUTE: University of Leuven (KUL) Department of Nuclear Medicine, U.Z. Gasthuisberg Herestraat 49 B-3000 Leuven


+32 16 34 3715 [email protected] +32 16 34 3759


Luc Mortelmans, MD, PhD. Head of Nuclear Medicine


[3] TYPE OF

CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No

Maximum beam available (µA) 70 50 Typical beam employed (µA) 45 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence 0 Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) 2 – Clinical 0 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






33

28


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F #1 — 20 GBq #2 — 70 GBq

97 #1 — 0,5 mL #2 — 2 mL

Yes


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 350 GBq 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 2 1/week Yes No Yes No Acetate 2 0,5/week Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N H3 2 3/week 16O(p,x) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H215O 2 2-3/week 14N(d,n)


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


34

29


[1] INSTITUTE: Vrije Universiteit Brussels Eenheid Cyclotron Laarbeeklaan 103, B-1090 Brussels


+32 2 4774 864 or +32 2 477 4860 [email protected] [email protected] +32 2 477 4855


Professor A. Hermanne Head, Cyclotron Department


Professor P. Van den Winkel Professor J. Mertens

[3] TYPE OF

CYCLOTRON: AVR YEAR OF:


MANUFACTURER: CGR France (II) UPGRADE: MODEL: 560 [4] CYCLOTRON CHARACTERISTICS: All beams are extracted with an electrostatic deflector – average 50%. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-42 10-22 20-50 20-43 Yes No

Maximum beam available (µA) 100 100 10 20 Typical beam employed (µA) 2-30 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications


Materials science: 7 Proton therapy:







Intense neutron beam? (specify average En = ?) Yes No En > 25 MeV. Thin targets

neutron TOF spectroscopy

[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Neurotensin analogues; 18F peptides and aromatic amino acids; Pd- 103 for research labelling and rodent studies;

188Rh 186Rh [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? RUG , SCK Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? In academic hospitals – Nuclear Medicine

Yes No


511 KeV coincidence 1 Gamma camera > 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) –Clinical From June 2001 –Small animals collaboration with RUG –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for





[16] Does your institute accept IAEA research fellows for training/experience Yes No

35

30


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 16 95 0.45 40 Yes


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 37 2-4 /week Yes No Yes No Stopped in

1996 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

Additional labelled compounds: 77Br, 56Co, 123I , 111In, 206Tl neurotensin analogues, 123I peptides and aromatic amino acids

36

31

5. BRAZIL

2005 COUNTRY: BRAZIL BRA-1

[1] INSTITUTE: Instituto de Engenharia Nuclear (IEN) Caixa Postal 68550, Cidade Universitária S/N – Ilha do Fundão 21945-970 – Rio de Janeiro – RJ

TELEPHONE NO.: E-MAIL ADDRESS:

+55 21 560-4113 ext. 2184 [email protected]


Dr. Julio Cezar Suita Head, Radiopharmaceutical Division


Ana Maria Silveíra Braghirolli José Antônio Dias Furlaneto Jackson Louis Queiroz de Britto Migual Ângelo Valle Bastos

[3] TYPE OF

CYCLOTRON: Isochronous YEAR OF:



(II) UPGRADE:

MODEL: CV-28 [4] CYCLOTRON CHARACTERISTICS: Variable energy and multiparticle 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No

Maximum beam available (µA) 50 75 30 25 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No Occasionally

Mössbauer sources? (specify which & quantity) Yes No Occasionally

X ray sources? (specify which & quantity) Yes No Occasionally

Intense neutron beam? (specify average En = ?) 17 MeV Yes No Occasionally

[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): n-isopropyl para-iodine anphetamine labelled with 123I [9] Do you supply radionuclides to other institutions?



Yes No








37

32


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (ml) 18

O2 (l)

18O (p, n) 18F 11 96 0.3 30 Yes


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

18FDG 6 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 15 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Meta – iodinebenzilguanine labelled with 123I has also been produced.

38

33

2005 COUNTRY: BRAZIL BRA-2 [1] INSTITUTE: Instituto de Pesquisas Energéticas e Nucleares – IPEN/CNEN-

SP Travesa , R, 400, Cidade Universitária CEP – 05508-900, São Paulo, SP


+55 11 3816 9275/ 9265 [email protected] +55 11 3816 9263


Dr. Wanderley de Lima Head, Cyclotron Laboratory


Dra. C. Pagano G. da Silva, Head – Radioisotope Department Uylton Matsoda Valdir Sciani

[3] TYPE OF

CYCLOTRON: Fixed field, fixed frequency

YEAR OF: (I)

INSTALLATION 1998

MANUFACTURER: TBA, S.A. (II) UPGRADE: MODEL: Cyclone - 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 500 Typical beam employed (µA) 200 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 201Tl, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals and medical centers/

weekly

Yes No


Yes No





39

34


production

yield (GBq)

% Isotopic

enrichment

18O used

Target Volume Usage/year 18

OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 94 2 200 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq

FDG 500 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq


(list)

Typical yield on

batch (GBq)

Frequency of

production

Nuclear reaction used Distribution/sales Price/G

Bq


(list)


used

Price/G

Bq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga 50 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 1/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) As of June 2001, MIBG 123I, HEPPURAN 123I and radiopharmaceutical for neuroreceptors are produced.

40

35

6. CANADA

2005 COUNTRY: CANADA CAN-1

[1] INSTITUTE: Clark Institute of Psychiatry 250 College Street Toronto, ON M5T 1R8


+1 416 979 4651 +1 416 979 4656


Dr. Sylvain Houle Head, PET Centre


Allan A. Wilson Jean Da Silva

[3] TYPE OF

CYCLOTRON: Fixed energy isochronous

YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 15-60 20-25 Typical beam employed (µA) 10-40 10-12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-25 20-22 2-3 (additional 1-weekmaintenance/y)

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






41

36


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Yes


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 11C-raclopride Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq 15O-water OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

42

37

2005 COUNTRY CANADA CAN -2 [1] INSTITUTE: Edmonton PET Centre, Cross Cancer Institute

Edmonton, AB, T6G 1Z2, Canada TELEPHONE NO.:


780-989-4311 [email protected] 780-432-8483


Steve McQuarrie, PhD Director, Cyclotron Operations and Professor, Faculty of Medicine, University of Alberta


John Wilson, PhD Sr. Cyclotron Operator

[3] TYPE OF

CYCLOTRON: MANUFACTURER: MODEL:

Negative ion Advanced Cyclotron Systems TR19/9


2001 N/A


Beam energies (MeV) 19 9 Yes x No Maximum beam available (µA) 200 100 200 Typical beam employed (µA) 75 20 75 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

30 30 1 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:



Activation analysis: Other (Medical research) 30


Calibration sources? (specify which & quantity) Yes No X

Mössbauer sources? (specify which & quantity) Yes No X

X ray sources? (specify which & quantity) Yes No X

Intense neutron beam? (specify average En = ?) Yes No X

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Radionuclides: 124I, 64Cu, 86Y Radiopharmaceuticals: Development of new tracers to study metabolic processes in cancer. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes X No

Foothills Hospital, Calgary. 3 – 4/week Health Sciences Centre, Winnipeg. 3 -4/week [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes X No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) –Clinical 3 –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? Yes No X

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No X [14] Is the cyclotron used for targetry development? Yes X No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes X No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

43

38


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 180 95 2 Yes X No

Ne (d, α) 18F 0

16O (α, x) 18F 0 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG 50 - 100 3/day Yes X No Yes X No 18FES 2 - 10 1/week Yes X No Yes No X 18FLT 2 - 10 1/week Yes X No Yes No X 18FAZA 2 - 10 3/week Yes X No Yes No X 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 11C-choline Yes X No Yes No X Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I < 0.05 1 – 4 /month Yes X No Yes No X 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

The Edmonton PET centre is a basic science and translational research centre whose mission is the discovery, elucidation and clinical evaluation of the molecular mechanisms associated with cancer.

44

39


[1] INSTITUTE: Hamilton Health Sciences Corporation Department of Nuclear Medicine Mc Master Site, 1200 Main Street West, Room 1 P 6 Hamilton, ON L8N3Z5


+1 905 521 2100 ext. 76893/73025 [email protected] +1 905 546 1125


Dr. Raman Chirakal Radiochemist


Jia Juen Chen

[3] TYPE OF

CYCLOTRON: RDS 112 YEAR OF: (I)

INSTALLATION 1990

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Negative ion cyclotron 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

5 3 2 1 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 3 Radiography:



Activation analysis: Other (specify) Research - 2







If yes and available, name of institution/s & how often? Ottawa Heart Institute, 1/week Yes No


Yes No





45

40


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 18.5 94 0.8 14 200 10 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 10 6/week Yes No Yes No J6 – F MT 1.12 1/week Yes No Yes No J6 - FDOPA 0.3 2/month Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

ACETATE 0.3 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

AMMONIA 0.8 4/week 16O(p, α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

WATER 5.6 9/month OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

46

41


[1] INSTITUTE: Montreal Neurological Institute McGill University 3801, University Street Montreal, Quebec H3A2BA


+1 514 398 8526 [email protected] +1 514 398 8540


Prof. Mirko Diksic


Dean Jolly

[3] TYPE OF

CYCLOTRON: Negative ion YEAR OF: (I)

INSTALLATION 1993

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 100 60 Typical beam employed (µA) 30-40 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-30 20-30 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





47

42


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F-FDG Yes No Yes No 18F-DOPA Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-RO Yes No Yes No Deprenyl Yes No Yes No α-methyl- L-trypotophan

Yes No Yes No

Bensotropine Yes No Yes No PK-11195 Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


48

43


[1] INSTITUTE: TRIUMF 4004 Westbrook Mall Vancouver, BC V6T 2A3


+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Stefan K. Zeisler Manager, Applied Technology Groups


Mr. R. Van Den Elzen

[3] TYPE OF

CYCLOTRON: H- / sector-focused YEAR OF: (I)

INSTALLATION 1990

MANUFACTURER: EBCO (II) UPGRADE: 1995 MODEL: TR30 [4] CYCLOTRON CHARACTERISTICS 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 1200 Typical beam employed (µA) 1000 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





49

44


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd ~7/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 3/week Yes No Yes No 201Tl ~5/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.

50

45


[1] INSTITUTE: TRIUMF 4004 Wesbrook Mall Vancouver, BC V6T 2A3


+1 604 222-7364 [email protected] +1 604 221-0436


Dr. Stefan K. Zeisler Manager, Applied Technology Group


Mr. R. van den Elzen

[3] TYPE OF

CYCLOTRON: H- / sector-focused YEAR OF: (I)

INSTALLATION 2002

MANUFACTURER: EBCO MODEL: TR30-2 [4] CYCLOTRON CHARACTERISTICS 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 1200 Typical beam employed (µA) 1000 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





51

46


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd ~7/week Yes No Yes No 111In Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.

52

47




+1 604 222-7364 [email protected] +1 604 221-0436





[3] TYPE OF

CYCLOTRON: 520 MeV H-/ sector-focused

YEAR OF: (I)

INSTALLATION 1962

MANUFACTURER: TRIUMF (II) UPGRADE: 1997 MODEL: [4] CYCLOTRON CHARACTERISTICS: Isotope production beam line only 1H 2H 3He 4He Dual Beams Beam energies (MeV) 500 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 70 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

144 4 months/year [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





53

48


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 82 Sr/ 82Rb, Mo(p, spall) — ~ 8 targets/year

54

49




+1 604 222-7364 [email protected] +1 604 221-0436





[3] TYPE OF

CYCLOTRON: H-/sector-focused YEAR OF: (I)

INSTALLATION 1980


(II) UPGRADE: 1991

MODEL: CP42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 42 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

168 158 1 9 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? University of British Columbia, Botany Department, 1-2 times/week

Yes No


Yes No





55

50


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F YeNo


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

13N – NO3 7 1/week 16O(p, α) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/month Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Yields and prices of commercial products are confidential and cannot be reported.

56

51


[1] INSTITUTE: UBC/TRIUMF PET Programme 4004 Wesbrook Mall Vancouver, BC V6T 2A3


+1 604 222 1047 [email protected] +1 604 222 1074


Dr. Thomas Ruth PET Director/Senior Research Scientist


Ken Buckley, PET Project Engineer

[3] TYPE OF

CYCLOTRON: Negative ion, sector focused

YEAR OF: (I)

INSTALLATION 1994

MANUFACTURER: EBCO (II) UPGRADE: MODEL: TR13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Same as below. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Various, on request Yes No


Yes No





57

52


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F F 2 – 18.5 F -26

>90 0.5 500 50 1 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 3.7 1/week Yes No Yes No 18F SETOPERONE 1.8 1/week Yes No Yes No 18F DOPA 0.8 2/week Yes No Yes No 18F EF5 0.8 <1/week Yes No Yes No 18F FHBG 0.8 <1/week Yes No Yes No 18F FLT 0.8 <1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 1.1 3/week Yes No Yes No Schering23390 1.1 <1/week Yes No Yes No Carfentanil 1.1 <1/week Yes No Yes No DHTBZ 1.1 3/week Yes No Yes No NK 1.1 <1/week Yes No Yes No Methylphenidate 1.1 3/week Yes No Yes No Pk 11195 1.1 <1/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NOX 3.0 3/week 16O (p, α ) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C PMP, 1.1 GBq, 1/week

58

53

7. CHINA

2005 COUNTRY: CHINA CPR-1

[1] INSTITUTE: China Institute of Atomic Energy P.O. Box 275 (99) Beijing 102413


+86 01 69358090 +86 01 69357195


Dr. Li Da Kang


Zhao Gui Zhi; Zhao Zhen Lu Shen de Heng Xu Shu He

[3] TYPE OF


INSTALLATION 1995

MANUFACTURER: IBA sa (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) Typical beam employed (µA) 100-220 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

4 days/week 4 days/week 1 day/week [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 186Re [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 57Co to USA 1 per month Yes No


Yes No





59

54


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F 16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


60

55


[1] INSTITUTE: Guangdong Province People's Hospital 96 Dong Chuan Road Guangzhou 5 10 100


+11 86 20 8382 7812 +11 86 20 8382 5453


Dr. Tang Au-Wu


[3] TYPE OF

CYCLOTRON: YEAR OF: (I)

INSTALLATION 1999

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.1 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 38.5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?



Yes No





61

56


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1.2 260 Yes No

Ne (d,α) 18F 16O (α , d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 30 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

AMMONIA 4 1/week 16O (p , α ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 22 3/month 15N (p , n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


62

57

2005 COUNTRY: CHINA CPR-3 [1] INSTITUTE: Hong Kong Sanatorium & Hospital, Ltd.

Department of Radiology & Radiotherapy 2 Village Road, Happy Valley Hong Kong


+11 852 2835 8989 +11 852 2835 8825


Dr. C.L. Ho Director, Department of Nuclear Medicine and PET


Dr. David W.C. Young, Deputy Director Mr. Steve H.Q. Sitt, Manager Dr. M.K. Cheung, Radiochemist

[3] TYPE OF

CYCLOTRON: - YEAR OF: (I)

INSTALLATION 1998

MANUFACTURER: CTI, Inc. (II) UPGRADE: - MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

6 5 – 18F; 1 – 11C 1 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O-oxygen; 18F-Fluoroestradiol, 18F-choline, 18F-fluoro-α-methyltyrosine, 18F-DOPA [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






63

58


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F ~ 37 95 1100 Y No

Ne(d, α) 18F 16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG ~ 15 5 batches/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate ~ 3.7 1-2/week Yes No Yes No Choline ~ 3.7 1/month Yes No Yes No Methionine ~ 3.7 1/ month Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia ~ 1.8 1/month O(p, α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


64

59


[1] INSTITUTE: Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education of China Beijing Normal University Beijing ,100875 , P. R. China


+86-01-6220 7786 [email protected] +86-01-62207786


Professor Lin Zhu


Zhi-Gang Tang/senior Engineer Zheng-Hao Liu/Professor Ming-Da Hua/Professor

[3] TYPE OF

CYCLOTRON: Positive ion YEAR OF:


MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-22 [4] CYCLOTRON CHARACTERISTICS: Our CS-22 will be used to produce radiopharmaceuticals in 2002. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 11 29 Yes No Maximum beam available (µA) 50 50 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18 F, 67 Ga, 111In, 18 FDG, 18F - DOPA [9] Do you supply radionuclides to other institutions?



Yes No


microSPECT 1 Next year [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



65

60


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 95 0.3 Yes No

18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No 18F - DOPA Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


66

61


[1] INSTITUTE: Institute of Applied Chemistry Beijing Normal University Bejing Cyclotron Produced Radiopharmaceutical Laboratory 100875 Beijing, China P.R.


+86 01 6220 7786 or 8396 [email protected] +86 01 6220 0567


Professor Bo Li Liu Dean of Radiochemistry


Huang Zheng Xing Professor Liu Zheng Hao Zhang Hui Xing Chen Ru Yi

[3] TYPE OF



MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26 15 30 Yes No Maximum beam available (µA) 200 200 100 Typical beam employed (µA) 110 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





67

62


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F 16O (α , d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

68

63

COUNTRY: CHINA CPR-6 [1] INSTITUTE: Peking Union Medical College Hospital

Nuclear Medicine Department PET Centre Beijing 100730


+86 10 652 33129 +86 10 652 33129


Dr. Chien Chou


[3] TYPE OF


INSTALLATION 1998

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 35-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

4 – 8 2 - 3 1 - 2 1 - 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No


511 KeV coincidence EXACT HR + Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



69

64


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 14.8 - 29.6 > 94 1.1 Ye No

Ne (d, α) 18F 16O (α , d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG 7.4 – 11.1 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F-F–Ethyl–tyrosine: not in clinical trial yet.

70

65


[1] INSTITUTE: Shanghai Institute of Nuclear Research P.O. Box 800-204 201800 Shanghai


+86 21 5955 3634 [email protected] +86 21 5955 2509


Professor Wang Yongxian Director


Cao Benhong Gao Wenzhao Yuyi

[3] TYPE OF


INSTALLATION 1996

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 150 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

50 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





71

66


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F 16O (α ,d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG 5500 - 7400 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga 12950 - 14800 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 14800- 16650 2/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

72

67


[1] INSTITUTE: The PLA General Hospital 28 Fuxing Road Beijing 100853


+86 10 6693 9424 [email protected] or [email protected] +86 10 681 31142


Professor Jia-he Tian


Jinming Zhang

[3] TYPE OF


INSTALLATION 1999

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





73

68


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 1.1 150 YeNo

Ne (d,α) 18F 16O (α ,d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq

FDG 18.5 2-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq

Acetate 3.7 1-2/week Yes No Yes No Methioine 2 0-1/week Yes No Yes No RACLOPRIDE 2 0-1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq

AMMONIA 1.5 2/week 16O(p, α ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/G

Bq

WATER 74 0-1/week 15N(p, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

74

69


[1] INSTITUTE: Zibo Wanjie Hospital Boshan, Zibo Shandong


+86 533 4650 000 8730 +86 533 4650 830


Dr. Sun Qiyin


Wang Ming Fang Zhao Jun Wang Changqing Li Jiamin

[3] TYPE OF


INSTALLATION 1995

MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 82Rb [9] Do you supply radionuclides to other institutions?


[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No





75

70


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


76

71

8. CZECH REPUBLIC

2005 COUNTRY: CZECH REPUBLIC CZR-1 [1] INSTITUTE: Nuclear Physics Institute

Rez near Prague, 25068 Rez TELEPHONE NO.:


+420 2 6617 3613 [email protected] +420 2 20941130


Ing. Jan Stursa, MSc. Head of the Cyclotron Division


J. Kucera, Deputy Head J. Lacman, Control System M. Cihak, Beam Dynamics

[3] TYPE OF

CYCLOTRON: Isochronous YEAR OF: (I)

INSTALLATION 1977 First beam

MANUFACTURER: JINR Dubna, Russia (II) UPGRADE: 1992 Axial injection MODEL: U-120M 1997 H-, D- Beams

2000 New beam line [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-38 10-20 17-53 20-40 Yes No Maximum beam available (µA) 40 25 3 3 Typical beam employed (µA) 20 10 3 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) - Stent

activation





Intense neutron beam? (specify average En = ?) = 15 MeV Yes No 7

[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 86Y, 123I [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) - Clinical - Small animal - Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



77

72


production

yield (GBq)

% Isotopic

enrichment

18O used


OH2

?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 80 95 2.0 1000 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 45 12/week Yes No Yes No 335

USD Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 4 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I clinical studies Yes No Yes No 124I Yes No Yes No 201Tl 4 1/week Yes No Yes No 211At 1 1/month Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/81mKr – radionuclide generator, 3/week, not used on site, distribution – yes.

78

73

2005 COUNTRY: CZECH REPUBLIC CZR-2

[1] INSTITUTE: Nuclear Research Institute Rez plc 250 68 Rez


+42 02 572 16 982 or +42 02 570 90 616 mailto:[email protected] or ami@ ujv.cz +4202 572 15 949


Ing. Michal Antos Head, Department of PET Radiopharmaceuticals


Ing. Karel Mudra, Cyclone Operator Ing. Petr Kopecky, Vice Director – Division of Radiopharmaceuticals

[3] TYPE OF

CYCLOTRON: IBA cyclone YEAR OF: (I)

INSTALLATION 1999

MANUFACTURER: IBA Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Possible, but

not used Typical beam employed (µA) Up to 37 not used [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No 18

F -5 GBq/year




[8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F- FDG, 11C- labelled pharmaceuticals [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yellow Hill Hospital Brno,FDG twice per day

Yes No


Yes No


511 KeV coincidence 0 Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 2 1xPET,

1xPET/CT - Clinical x - Small animal - Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



79

74


production yield

(GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 140/2hrs-large 65/1,5hrs-medium

>95 2,0 (2x)-large 1,0 (1x)-medium

32g/week totally

Ye No

20Ne (d, α) 18F Not used 16O (α, d) 18F Not used 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 50 –large volume 2x/ day Yes No Yes No 18FDG 20-medium

volume 1x/ day Yes No Yes No

Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Routine production of FDG only – Monday to Thursday 3 batches per day, Friday to Sunday 2 batches per day.

80

75

9. DENMARK

2005 COUNTRY: DENMARK DEN-1

[1] INSTITUTE: University Hospital of Copenhagen Cyclotron and PET Unit, KF 3982 Blegdamsvej 9, DK – 2100 Copenhagen


+45 3545 3915 [email protected] +45 3545 3898


Dr. Mikael Jensen Physicist-in-Chief


Holger Jensen, Physicist Nic Gillings, Chemist Jacob Madsen, Chemist

[3] TYPE OF

CYCLOTRON: Negative ion, sector-focused

YEAR OF: (I)

INSTALLATION 1992

MANUFACTURER: Scandinotrix (II) UPGRADE: 1994 – Addition of positive ions and 4He

MODEL: MC 32-NI [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 16 - 32 Yes No Maximum beam available (µA) 100 80 30 Typical beam employed (µA) 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

30-40 25 5 2 0-8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) Space component tests






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – FLB 457 [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



81

76


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 >95 1.2 200 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available 18FDG 25 2-3/week Yes No Yes No ~600 Euro 18F -ALTANSERIN 4 1/week Yes No Yes No ~400 USD

per. patient dose


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2 2-8/week 16O (p, α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water on line 8 hours/week 14N (d, n ) 15O CO on line 14N (d, n ) 15O OO on line 14N (d, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 5/year Yes No Yes No 201Tl Yes No Yes No 211At 1 1/week Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) The home of : gas phase Methyl iodine - 11C, 10C - carbon dioxide Production of 81Rb/ 81mKr generators 16/week – 12 GBq/week.

82

77

2005 COUNTRY DENMARK DEN-2 [1] INSTITUTE: The Hevesy Laboratory

Risø National Lab P.O.Box 49, DK 4000 Roskilde, Denmark


+45 4677 5300 [email protected] +45 4677 5347


Mikael Jensen Professor

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION

Head of Programme Lars Martiny Radiochemist Palle Rasmussen Physicist Dennis Ringkjøbing Radiochemist Sorin Aburel

[3] TYPE OF


Compact, negative ion General Electric Pettrace


2004


Beam energies (MeV) 16,5 8 Yes X No Maximum beam available (µA) 100 60 Typical beam employed (µA) 60 50 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 3 –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes x No


83

78


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 150 95-97 2,1 Yes X No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 100 2/week Yes No X Yes X No 18FDOPA 0.4 1/month Yes No Yes No 18Fluoride 0.5 1/month Yes No Yes No 18FMISO 2 1/month Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 0.5 1/week Yes No Yes No PK11195 0.5 1/month Yes No Yes No Acetate 5 1/month Yes No Yes No Methonine 3 1/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 2/week 16O(p,α) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 3 daily 14N(d,n) Oxygen 6 1/week 14N(d,n) CO 3 1/week 14N(d,n) OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 3 1/mo Yes x No Yes x No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

84

79

10. EGYPT

2005 COUNTRY EGYPT EGY-1 [1] INSTITUTE: Cyclotron Project, Nuclear Research Center

Atomic Energy Authority, 13759, Egypt


+(202)4620786 +(202)4620786


Ppof.Dr. Sh.M. Saad Supervisor


Prof.Dr. M.N.H. Comsan Prof.Dr. Z.A. Saleh Dr. S. Abdel-Samad

[3] TYPE OF


AVF NIIEFA MGC-20


2000


Beam energies (MeV) 5-18 3-10 8-24 6-20 Yes No X Maximum beam available (µA) 50 50 25 25 Typical beam employed (µA) 30 -- 10 10 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

40 Not yet 30 10 -- [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): I-123, Ga-67, In-111, Cu-64 [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No X


Yes No X




Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes X No [14] Is the cyclotron used for targetry development? Yes X No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes X No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

85

80


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F In plan In plan In plan Ye No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Trial Yes No Yes No 67Ga Trial Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Trial Yes No Yes No 123I Trial Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

86

81

11. FINLAND

2005 COUNTRY: FINLAND FIN-1 [1] INSTITUTE: Laboratory of Radiochemistry

University of Helsinki, Department of Chemistry P.O. Box 55, 00014 University of Helsinki


+358 9191 50133 [email protected] +358 9191 50121


Dr. Kerttuli Helariutta , Senior Laboratory Manager


Martti Hakanen, Laboratory Manager

[3] TYPE OF


INSTALLATION 1997

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 10-20 Not yet used [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

~ 4.5 ~ 4 ~ 0.5 ~ 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:

Materials science: A couple of times Proton therapy:





Mössbauer sources? (specify which & quantity) Yes No 57

Co

X ray sources? (specify which & quantity) Yes No 109

Ag


[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I, 64Cu , 86Y [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals (Helsinli, Tampere, Lahti, Kuojno) 1-3 times/week

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) - Clinical - Small animal - Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



87

82


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1-5 0.4, 2.0 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are still in the beginning of using Cyclotron. Probably this year, the production of radionuclides will increase significantly.

88

83

2005 COUNTRY: FINLAND FIN-2

[1] INSTITUTE: Turku PET Centre Turku University Central Hospital Kiinamyllynkatu 4-8 FIN-20520 Turku


+358 2 313 1860 [email protected] +358 2 313 2882


Mr. Hannu Sipilä Chemist


Mika Teräs, Hospital Physicist Kari Lindberg, Technician Jukka Kaikkonen, Technician

[3] TYPE OF

CYCLOTRON: Positive ion 2H YEAR OF: (I)

INSTALLATION 1992

MANUFACTURER: IBA, s.a. Belgium (II) UPGRADE: MODEL: Cyclone 3 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-7 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 5-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

14 14 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 14












Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 4 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



89

84


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

H2 O 0.2 – 1.4 4 days/week 14N (d, n) 15O CO 2.6 0-1 days/week O2 1.2 0-1 day/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


90

85

2005 COUNTRY: FINLAND FIN-3 [1] INSTITUTE: Turku PET Centre

Accelerator Laboratory Äbo Akademi, Porthansgatan 3 FIN-20500 Turku


+358 2 2654 608 [email protected] +358 2 2654 912


Dr. Sven-Johan Heselius Director


Olof Solin; Jörgen Bergman; Jan-Olof Lill; Ulf Hällsten; Stefen Johansson; Erkki Stenvall; Per Olof Eriksson

[3] TYPE OF

CYCLOTRON: AVF YEAR OF: (I)

INSTALLATION 1974

MANUFACTURER: D.V. Efremov Institute

(II) UPGRADE:

MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-20 6-10.5 9-28 12-21 Yes No Maximum beam available (µA) 30 30 20 20 Typical beam employed (µA) 300 300 80 80 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? ……. Yes No


Yes No


511 KeV coincidence 2 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



91

86


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced

92

87

2005 COUNTRY: FINLAND FIN-4 [1] INSTITUTE: University of Jyväskylä

Department of Physics, P.O. Box 35 40351 Jyväskylä


+358 14 260 2350 [email protected] +358 14 260 2351


Professor Esko Liukkonen Professor


Pauli Heikkinen, in charge of Accelerator Physics Hannu Koivisto, in charge of Ion Sources Teuvo Poikolainen, Radiation Safety Officer

[3] TYPE OF



MANUFACTURER: JYFL, Scandinotrix (II) UPGRADE: 2000 for H- acceleration MODEL: [4] CYCLOTRON CHARACTERISTICS: E = q2 m 130 MeV 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-70 5-65 15 - 168 Yes No Maximum beam available (µA) 100 50 20 Typical beam employed (µA) 30-50 0.1 - 10 0.1 - 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





93

88


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 150 1/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced

94

89

12. FRANCE

2005 COUNTRY: FRANCE FRA-1

[1] INSTITUTE: Centre Antoine Lacassagne Laboratoire du Cyclotron 227, Avenue de la Lanterne, 06200 Nice


+33 4 920 31070 [email protected] +33 4 920 31095


Dr. Pierre Mandrillon Head of Cyclotron Laboratory


Donadey Trimud Giusto

[3] TYPE OF

CYCLOTRON: Compact isochronous - negative ion

YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: Centre Antoine Lacassagne

(II) UPGRADE:

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 65 65 65 65 Yes No Maximum beam available (µA) 40 40 40 40 Typical beam employed (µA) 0.1 - 25 0.1 - 25 0.1 - 25 0.1 - 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications


Materials science: Proton therapy: 20








[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C [9] Do you supply radionuclides to other institutions?



Yes No





95

90


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 150 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


96

91

2005 COUNTRY FRANCE FRA-2 [1] INSTITUTE: CNRS/CERI

3a rue de la Férollerie 45071 Orléans cedex 2 France


+33238255410 [email protected] +33238630271


Gilbert Blondiaux Director


J.Briaud : Technical director L.Le Polotec : assistant of the technical director M.F.Barthe : leader of the research staff

[3] TYPE OF


K50 isochronous CGR MeV


1974 upgraded continuous by the technical staff from 1998-2005


Beam energies (MeV) 36 25 65 50 Yes No X Maximum beam available (µA) 50 40 10 5 Typical beam employed (µA) 50 40 5 5 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

64 6 30 8 20 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:


Physics: Neutron therapy: 20






Intense neutron beam? (specify average En = ?) Yes X No 25

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F for FDG and fluoride, 11C, 81mKr, 64Cu, 123I, [9] Do you supply radionuclides to other institutions?



Yes No X


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical –Small animal 1 in end 2006 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No X

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? X No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

97

92


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 0.1 3/month Yes No X Yes No X [17] COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

We are installing on the site a production of classical 511 keV positrons emitter form PET imaging of small animals. We are also starting this month a production of 211At for research A large part of the beam time of this machine is utilized for nuclear waste management studies (alpha radiolysis simulation with external beam). A project of boron capture enhance fast neutron therapy is also under progress.

98

93


[1] INSTITUTE: Centro d'Exploration et de Recherche Medicales par Emission de Positrons (CERMEP) Cyclotron Biomedical de Lyon 59 Boulevard Pinel, F-69003 Lyon


+33 4 726 88600 [email protected] +33 4 726 88610


Dr. D. Le Bars Head of Radiochemistry


G. Galy P. Lanai D. Comar

[3] TYPE OF



MANUFACTURER: CGR-MeV (II) UPGRADE: MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No

Maximum beam available (µA) >50 >50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

>15 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? 18F-FDG one per/month to one per week.

Yes No


Yes No





99

94


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


100

95


[1] INSTITUTE: CERMEP – Imagerie du Vivant Hopital Neurocardiologique 59 Bd Pinel F - 69003 Lyon




Dr. Gimenez Director


Dr. D. Le Bars, Head of Radiochemistry Radiopharmacy Dr. L. Zimmer, Radiopharmacology Radiopharmacy Dr. S. Guillouet, Radiochemist

[3] TYPE OF

CYCLOTRON: CYCLONE 18/9 YEAR OF: (I)

INSTALLATION 1999

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 15-35 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





101

96


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 25-75 >95 0.5 50-100 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 10 3/week Yes No Yes No DOPA 6 1/week Yes No Yes No MPPF 3 3/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 2 1/week Yes No Yes No Flumazenil 2 1/week Yes No Yes No Raclopride 2 1/week Yes No Yes No Diprenorphine 2 2/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/G

Bq


(list)


used

Price/G

Bq

Water 0.33 2/week 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) [11C]acetate, [11C]MQNB, [11C]PE2I; [18F]FLT, [18F]FCH, [18F]NaF

102

97

2005 COUNTRY FRANCE FRA-5 [1] INSTITUTE: CNRS CERI

45071 Orleans Cedex 02 France


33 2 38 25 54 05 [email protected]


Joseph Briaud Engineer

OTHER SENIOR STAFF: [3] TYPE OF CYCLOTRON

MANUFACTURER: MODEL:

Compact CGR-MeV 680


1971


Beam energies (MeV) 38 25 65 50 Yes No x Maximum beam available (µA) 40 40 10 10 Typical beam employed (µA) 40 20 1 1 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications




Activation analysis: 10 Other (specify) 10





Intense neutron beam? (specify average En = ?) Yes x No

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F by 18O (p, n) 18F 11C 64Cu 123

I

[9] Do you supply radionuclides to other institutions?


For the moment we deal with industrial partnerships the conditions of production and

delivery radionuclides(frequency, activityies,…).

[10]

Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?

Yes No X


511 KeV coincidence 2 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No x


103

98


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

104

99

2005 COUNTRY FRANCE FRA-6 [1] INSTITUTE: Advanced Accelerator Applications

20 rue Diesel 01630 Saint-Genis-Pouilly France


+33-4-50993070 [email protected] +33-4-50993071


Stefano Buono President & CEO


Luca Maciocco/cyclotron engineer & researcher Vincent Tadino/research radiochemist Philippe Dasse/responsible radiopharmacist

[3] TYPE OF


Negative ions, fixed energy General Electric PETrace


2003


Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 42 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radionuclide production


maintenance

Hours/week for

applications

…… 30 10 8 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): F-MISO (2005) [9] Do you supply radionuclides to other institutions?



Yes No





105

100


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 160 98 1.6 2500 Ye No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 90 3/day Yes No Yes No 18F-Choline 20 2/week Yes No Yes No 18FLT 20 2/week Yes No Yes No 18

MPPF 10 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name (list) Yield on batch

(GBq)

Frequency of

production


sales

Price/


106

101

13. GERMANY

2005 COUNTRY: GERMANY GER-1

[1] INSTITUTE: Cyclotron Laboratory Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe


+49 7247 82 2433 [email protected] +49 7247 82 3156


Dr. H. Schweickert Director, Cyclotron Laboratory


Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique

[3] TYPE OF


INSTALLATION 1984

MANUFACTURER: Cyclotron Corporation

(II) UPGRADE: Continuous

MODEL: CP 42 H- [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-40 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

140 50 70 when needed 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) TLA







If yes and available, name of institution/s & how often? To hospitals and industry Yes No


Yes No





107

102


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 75-150 >95 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 37 - 75 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Planned Yes No Yes No 94mTc Planned Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 175 1/day Yes No Yes No 124I 3.7 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

108

103


[1] INSTITUTE: Cyclotron Laboratory Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe


+49 7247 82 2433 [email protected] +49 7247 82 3156


Dr. H. Schweickert Director, Cyclotron Laboratory


Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique in Mechanical Engineering

[3] TYPE OF

CYCLOTRON: Positive ion YEAR OF: (I)

INSTALLATION 1964

MANUFACTURER: AEG (II) UPGRADE: Continuous MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 52 104 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





109

104


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F >95 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 1/week Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

110

105


[1] INSTITUTE: Eberhard-Karls-University Tübingen Interdisciplinary PET Centre, Radiopharmacy Röntgenweg 15, D-72076 Tübingen


+49 7071 29 87443 [email protected] +49 7071 29 5264

[2] PERSON IN CHARGE: Professor Dr. H.-Juergen Machulla OTHER SENIOR STAFF:

NAME/POSITION NAME/POSITION

Dr. rer. nat. C. Solbach Dr. rer. nat. G. Reischl Dipl.-Ing. A. Stahlschmidt

[3] TYPE OF


INSTALLATION 1995

MANUFACTURER: GE (II) UPGRADE: MODEL: PETtrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No

Maximum beam available (µA) 75 Typical beam employed (µA) 35-55 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

15-20 15-20 15-20 1 15-20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 15-20 Radiography:










If yes and available, name of institution/s & how often? Katharinenhospital (Stuttgart) 4/week, Kernchemie (Mainz) 1/week, Dr. Hörr (Plochingen) 1/week, Universitätsklinikum RDI (München) 1/week

Yes No


Yes No


511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 2 Positron emission tomography (PET) –Clinical 2 PET and

PET/CT –Small animal 1 –Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



111

106


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 75 95 0.6 1000 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available

FDG 30 5/week Yes No Yes No FLT 10 1/week Yes No Yes No FAZA 10 1/week Yes No Yes No FMISO 10 1/week Yes No Yes No FEC 13 2/week Yes No Yes No Depends

on number of patients: ~100 €/GBq

11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available

Raclopride 4 3/week Yes No Yes No Methylphenidat 5 3/week Yes No Yes No DASB 6 1/week Yes No Yes No BTA-1 8 1/3 months Yes No Yes No 6-OH-BTA-1 6 1/3 months Yes No Yes No Cholin 30 4/week Yes No Yes No Depends

on number of patients: ~750 €/batch

Methionin 8 1/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/GBq

if available

Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/GBq

if available

Water 12 1/3month 14N(d, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 2/month Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.4 1/month Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

112

107


[1] INSTITUTE: Euro-PET GmbH Hugstetlerstrasse 55 D-79106 Freiburg


+49 761 270 9204 [email protected] +49 761 270 9200


Professor Dr. Peter Reuland

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITIO

Dr. Ursula Sahm, Chief Chemist Kenneth Stalmo, Technician Bernd Morasch, Chemist Dagmar Hentschel, Engineer

[3] TYPE OF

CYCLOTRON: Negative Ion YEAR OF: (I)

INSTALLATION 1996

MANUFACTURER: GE. (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: ……. 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 75 75 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

3 0.25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-carbon monoxide and carbon dioxide, 15O–water, carbon monoxide and oxygen. [9] Do you supply radionuclides to other institutions? To different institutions



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 - Clinical - Small animal - Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



113

108


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 110 >95 1.2 1000 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 35-45 8-10/week Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

(see comments) Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13NH3 10-13 10/year Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

N213O 8-10 50/year


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


114

109

2005 COUNTRY GERMANY GER – 5 [1] INSTITUTE: Forschungszentrum Rossendorf

Institut fuer Bioanorganische und Radiopharmazeutische Chemie P.O Box 51 01 19 01314 Dresden, Germany


+49 (0) 351 260 3170 [email protected] +49 (0) 351 260 3232


Prof. Dr. habil. Joerg Steinbach Director of the Institute


Dr. Frank Wuest, Head of PET Tracer Dept. Dipl.-Ing. Stephan Preusche, Head of PET Cyclotron Unit


Negative ion IBA, Belgium CYCLONE 18/9


1996


Beam energies (MeV) 18 9 ----- ----- Yes X No Maximum beam available (µA) 35 20 Possible for

1H, 2H; not used

Typical beam employed (µA) 30 15-18 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

13-25 13-25 for PET routine and R&D

3

[6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: --------- Radiography: ---------

Materials science: --------- Proton therapy: ---------

Physics: --------- Neutron therapy: ---------

Activation analysis: --------- Other (specify): RN

production

13-25


Calibration sources? (specify which & quantity) Yes X No 56Co (1-2)/year

some kBq







Yes X No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical, Small animal , Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No X


115

110


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O(p, n)18F 60-90 97 1.4 ml 300 Yes X No

20Ne(d, α)18F 8-11 600 ml Ne/F2

16O(α, x)18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

[18F]FDG 33-45 1/day Yes X No Yes X No [18F]FDOPA 1.2 2/week Yes X No Yes X No [18F]3-O-Methyl-FDOPA

1.2 2/week Yes X No Yes No X

[18F]NAF 1/week Yes X No Yes No X 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

[11C]Acetate 12-15 2/week Yes X No Yes No X Various research products

on request Yes X No Yes No X


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Currently not used

Yes No


(list)


used

Price/

GBq

[15O]H2O 5-6 2/month 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1.1 2/month Yes X No Yes X No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Our internet home pages: Forschungszentrum Rossendorf: http://www.fz-rossendorf.de Institut für Bioanorganische und Radiopharmazeutische Chemie: http://www.fz-rossendorf.de/pls/rois/Cms?pNid=130 CYCLONE 18/9 and 10/5 USER COMMUNITY: http://www.fz-rossendorf.de/pls/rois/Cms?pNid=531

116

111


[1] INSTITUTE: Forschungszentrum Rossendorf Institut für Bioanorganische und Radiopharmazische Chemie P.O. Box 510119, 01314 Dresden


+49 351 260 3170 [email protected] +49 351 260 3232


Professor habil. Bernd Johannsen Director of the Institute


F. Wuest, Head of PET Tracer Department St. Preusche, Head of Cyclotron Unit

[3] TYPE OF

CYCLOTRON: U-120 YEAR OF: (I)

INSTALLATION 1958

MANUFACTURER: NIIEFA St. Petersburg

(II) UPGRADE: 1989

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 7 14 28 Yes No

Maximum beam available (µA) Typical beam employed (µA) 50 50 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? External application of radionuclides generally

Yes No


Yes No





117

112


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

118

113


[1] INSTITUTE: German Cancer Research Centre (DKFZ) Im Neuenheimer Feld 280 D-69120 Heidelberg


+49 6221 550 3 [email protected] +49 6221 422 572


Dr. Gerd Wolber, Head, Cyclotron Operation Group Professor Dr. Wolfhard Semmler, Head – Biophysics


Professor Dr. Michael Eisenhut, Head – Radiochemistry

[3] TYPE OF

CYCLOTRON: Isochronous, negative ion

YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 32 NI [4] CYCLOTRON CHARACTERISTICS: Average magnetic field: 1.59 T; pole face diam.: 135 cm; accel. freq: 24.3 MHz;

2 Dees 90º; dual cold cathode ion source; total weight: 53 tons; total power dissipation: 185 kva. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-32 8-16 Yes No Maximum beam available (µA) 100 100 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

50 (aver), 1997-2000 25 15 2-5 45 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography:

Materials science: 2-3 Proton therapy:


Activation analysis: Other (specify) Neutron dosimetry - 2


Calibration sources? (specify which & quantity) Yes No 140 Pr



Intense neutron beam? (specify average En = ?) Yes No εn= 14MeV

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): see comments [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Dept. of Nuclear Medicine, Radiological Clinic of the University of Heidelberg; daily

Yes No


Yes No

Both [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number

511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal planned – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



119

114


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 50-70 >95 1 16 at 30 bar

300 1 Ye No

20Ne (d, α) 18F 20-30 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15-20 1-2/day Yes No Yes No FLT 1.7 on demand Yes No Yes No

Yes No Yes No Others, see comments Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Others, see comments Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 5-6 2-3/week 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu rare Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I in preparation Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F – DOPA, FU, FET, 2F-Throsine,Choline 11C – AIB, ethanole, doxorubicine, dacarbacine, acetate, choline In preparation : Iodinated compounds (124I, 121I) 140 Pr ( 20%β +,via 141Pr (p, 2n) 140 Nd is used for calibration of PET systems.

120

115


[1] INSTITUTE: Herz- und Diabeteszentrum NRW Universitaetsklinik der Ruhr-Universitaet Bochum Institut für Molekulare Biophysik, Radiopharmazie u. Nuklearmedizin Georgstrasse 11. D-32535 Bad Oeynhausen


+49 5731 97 1308 [email protected]/[email protected]/[email protected] +49 5731 97 1819


Professor W. Burchert Director of Institute


Ms. Petra Hadjilazaros (responsible for cyclotron operation) Mr. Harald Henneken

[3] TYPE OF

CYCLOTRON: Negative Ion YEAR OF: (I)

INSTALLATION 1994

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: d P 3He 4He Dual Beams Beam energies (MeV) 9 18 Yes No Maximum beam available (µA) 40 80 Typical beam employed (µA) 5 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 20 2 days quarterly [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 4-[18F]-FBA (in vivo identification and quantification of apoptotic cells with PET) [9] Do you supply radionuclides to other institutions?



Yes No





121

116


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 25 50

95 1 1.6

400 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F-FDG 20 5-7 syntheses/week Yes No Yes No 18F-Fluorine 5 10/year Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 3.7 4/week Yes No Yes No MHED 2.6 2/month Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4.5 4/day 16O(p, α ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 3 6/week 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


122

117


[1] INSTITUTE: Institut für Nuklearchemie Forschungszentrum Jülich GmbH D-52425 Juelich


+49 2461 614141 [email protected] +49 2461 612535


Professor H.H. Coenen


Professor S.M. Qaim Dr. M. Holschbach

[3] TYPE OF

CYCLOTRON: Fixed energy, two particle

YEAR OF: (I)

INSTALLATION 1997

MANUFACTURER: General Electric (II) UPGRADE: 1999 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No

Maximum beam available (µA) Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?

(radiochemistry) Yes No


123

118


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Flumazenil 3 2/week Yes No Yes No Raclopride 3 2/week Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 15 daily 14N(d, n) 15O Butanol 5 daily 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


124

119




+49 2461 614141 [email protected] +49 2461 612535




Professor S.M. Qaim Dr. J. Ermert Dr. K. Hamacher

[3] TYPE OF

CYCLOTRON: Baby Cyclotron YEAR OF: (I)

INSTALLATION 1987

MANUFACTURER: Japan Steel Works, Ltd.

(II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?

(radiochemistry) Yes No


125

120


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 60 96 1.5 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available 18FDG 30 4/week Yes No Yes No CPFPX 15 1/week Yes No Yes No FET 15 occasionally Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available

Methionine 1-3 occasionally Yes No Yes No Flumazenil 1-3 occasionally Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/GBq

if available

Ammonia 1 occasionally 16O(p, α ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/GBq

if available


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/GBq

if available 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

126

121




+49 2461 614141 [email protected] +49 2461 612535




Professor S. Qaim Dr. B. Scholten

[3] TYPE OF

CYCLOTRON: Variable energy compact


1976


(II) UPGRADE: 1986, 1991, 1997

MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-22 4-14 18-36 10-28 Yes No Maximum beam available (µA) 30 20 10 20 Typical beam employed (µA) 30 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 86Y, 94mTc and 12yI to several clinics under co-operative research

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



127

122


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 35 95 50 5 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2 on demand Yes No Yes No 94mTc 2 on demand Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.5 ½ weeks Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

128

123


[1] INSTITUTE: Institute for Medical Radiation Physics Hufelandstrasse 55 D-45122 Essen


+49 201 723 4182 +49 201 723 5907


Professor Dr. A. Bochisch Director


G. Hudepohl, Technician/Engineer

[3] TYPE OF

CYCLOTRON: Positive Ion, sector-focused

YEAR OF: (I)

INSTALLATION 1975


(II) UPGRADE:

MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No Maximum beam available (µA) 100 100 50 50 Typical beam employed (µA) 100 100 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 20 10 5 Neutrons 5 patient treatment

[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: research 5 Radiography:


Physics: research 5 Neutron therapy: 5










Yes No





129

124


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 16O (3He,p)18F

37

Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 18.5 3/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11CO2 37 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

O2 15/min 3/week 14N(din)15O CO2 15/min 3/week 14N(din)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y temporary Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 7.4 temporary Yes No Yes No 124I 3.7 temporary Yes No Yes No 201Tl Yes No Yes No 211At temporary Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):

130

125


[1] INSTITUTE: Institute of Radiology and Nuclear Medicine Adickes-Allee 51-53 60322 Frankfurt am Main


+49 69 95961 626 +49 69 95961 630


Professor G. Hoer


Dr. W.T. Kranert

[3] TYPE OF

CYCLOTRON: Negative ion H YEAR OF: (I)

INSTALLATION 1998

MANUFACTURER: CTI. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) Nuclide production for

Nuclear Medicine






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 94mTc, 124I [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? We can give addresses, after the cyclotron is established.

Yes No


Yes No





131

126


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 80 0.8 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 40 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

CO 5 1/week Yes No Yes No CO2 5 1/week Yes No Yes No Amino acids 5 1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 5 2/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 1/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) The cyclotron is not established so far.

132

127


[1] INSTITUTE: Max-Planck-Institut fuer Neurologische Forschung Gleueler Strasse 50 D-50931 Koeln (Lindenthal)


+49 221 4726 220 [email protected] +49 221 4726 298


Professor Wolf-Dieter Heiss Director


Professor Dr. Klaus Wienhard

[3] TYPE OF

CYCLOTRON: Baby cyclotron YEAR OF: (I)

INSTALLATION 1987

MANUFACTURER: Scandinotrix (II) UPGRADE: 2005 MODEL: MC 16 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often?

Yes No


Yes No


Positron emission tomography (PET) – Clinical 3 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



133

128


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15 95 1.2 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 10 4/week Yes No Yes No Dopa 1 2/week Yes No Yes No FLT 1 1/week Yes X No Yes No X FHBG 1 1/week Yes X No Yes No X 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 12 3/week Yes No Yes No Raclopride 5 2/week Yes No Yes No Flumazenil 10 1/week Yes No Yes No MPHA 8 1/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 6 25/week 14N(d,n) 15O

CO 5 1/month 14N(din)15O O2 5 3/month 14N(din)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 124I – FIAU with 124I from outside.

134

129

2005 COUNTRY GERMANY GER-15 [1] INSTITUTE: Medizinische Hochschule Hannover

Klinik für Nuklearmedizin Carl-Neuberg-Str. 1, D-30625 Hannover


+49 (0) 511 532 3085 [email protected]


Dr. Helmeke Head of the Cyclotron Group


Prof. Dr. W.H. Knapp / Director of Nuclear Medicine Prof. Dr. G.J. Meyer / Head of the Radiopharmazie Group

[3] TYPE OF


Isochronous, Scanditronix MC 35


1976/77


Beam energies (MeV) 7,5-35 3,8-18 5,6-47 7,5-35 Yes No X Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 30-40 30 15 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

18,5 (incl. stand by) 17 1,5 6 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:





Calibration sources? (specify which & quantity) Yes No x

Mössbauer sources? (specify which & quantity) Yes No x

X ray sources? (specify which & quantity) Yes No x

Intense neutron beam? (specify average En = ?) Yes No x




Yes X No


511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No X

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No X [14] Is the cyclotron used for targetry development? Yes X No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No X [16] Does your institute accept IAEA research fellows for training/experience? Yes No X

135

130


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 - 40 85-97 1,5 ml 200 Yes X No

Ne (d, α) 18F 1,8


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F-FDG 9-20 5 / week Yes X No Yes X No 18F-dopa 0,6 1 / week Yes X No Yes No X 18F-NaF 4 2 / week Yes X No Yes No X Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-acetic acid 6-10 2 / week Yes X No Yes No X 11C-methionine 2-5 1 / week Yes X No Yes No X 11C-m-Hed 0,5-1,5 1 / week Yes X No Yes No X Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15O[H2O] 0,15 2 / week 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At up to 0,16 1-2/week Yes X No Yes X No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/ radiopharmaceuticals being produced)

136

131

2005 COUNTRY GERMANY GER-16 [1] INSTITUTE: Klinik für Nuklearmedizin

Universitätsklinikum Aachen Pauwelsstraße 30 . 52057 Aachen . Germany


+49 241 80 88740 [email protected] +49 241 80 82520


Univ.Prof. Dr.med. Dr.med.habil. Udalrich Büll

OTHER SENIOR STAFF: Dr.rer.physiol. Berthold Müller [3] TYPE OF


Negative Ion CTI, Inc. RDS 111


1997



for radionuclide

production


maintenance

Hours/week for

applications

22 20 2 - [6] CYCLOTRON APPLICATIONS: Hours/week --- none --- Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera (planar) 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No


137

132

18F RADIONUCLIDE PRODUCTION --- none --- Production Typical

production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F

16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED --- none --- Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED --- none --- Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

[13N]NH4+ 4 50 (per month) 16O (p,α) 13N Yes No


(list)


used

Price/

GBq

[15O]H2O 1 20 (per day) 15N (p,n) 15O OTHER ISOTOPES PRODUCED --- none ---

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Aachen, 2005-09-28 B.Müller

138

133

2005 COUNTRY GERMANY GER-17 [1] INSTITUTE: Klinikum Rechts der Isar der Technischen Universitaet

Muenchen, Nuklearmedizinische Klinik und Poliklinik Ismaninger Strasse 22 D-81675 Muenchen / Germany


+49 (0)89 4140-2972 [email protected] +49 (0)89 4140-4841


Markus Schwaiger, MD Director


Hans-Jürgen Wester, PhD / Radiopharm. Chemistry Ingo Wolf, PhD / Targeting Michael Herz / FDG Production Petra Watzlowik / PET Tracer Production

[3] TYPE OF


Siemens / CTI RDS 112


1992 —


Beam energies (MeV) 10.5 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 - 40 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

16 16 — 2 — [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:












Yes No


511 KeV coincidence — Gamma camera 1 Single photon tomography (SPET) 4 Positron emission tomography (PET) –Clinical 2 –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No


139

134


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 45 97 0.7 700 Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBqe 18FDG 20.0 3 / day Yes No Yes No FLT 0.75 1 / week Yes No Yes No FET 3.0 2 / week Yes No Yes No RGD 0.75 2 / month Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

methionine 2.6 2 / week Yes No Yes No choline 6.0 3 / week Yes No Yes No flumazenil 1.5 1 / month Yes No Yes No BTA 1.2 1 / week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13NH3 1.2 4 / week 16O(p,α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H215O 1.2 2 / month


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


11C-hydroxyephedrine 2.2 GBq 1 / month 11C-diprenorphine 0.9 GBq 18F-octreotide 0.5 GBq 1 / week 18F-fluoride 1.2 GBq 1 / month

140

135


[1] INSTITUTE: Universitätsklinikum Hamburg-Eppendorf Klinik u. Poliklinik für Radiologie, Abteilung für Nuklaermedizin, Bereich Zyklotron u. Radiopharmazie Luruper Chaussee 149 D-22761 Hamburg


+49 40 8998 2968 [email protected] +49 40 8998 2960


Dr. Pal Mikecz Head


Uve Kirchner Dr. Oliver Schulze

[3] TYPE OF


INSTALLATION 1968

MANUFACTURER: Philips (II) UPGRADE: MODEL: 140/IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 16 42 30 Yes No Maximum beam available (µA) 130(internal) Typical beam employed (µA) 20(external) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 5-7/week Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural

applications such as plant biochemistry/research? Yes No


141

136


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 28 75-95 0.9 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15 10/week Yes No Yes No 18FLT 1-5 1 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

McN 5652z 1-3 4/week Yes No Yes No Choline 1 1 Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


142

137


[1] INSTITUTE: Universitätsklinikum Ulm, Abteilung Nukleamedizin Robert-Koch-Strasse 8 D-89081 Ulm


+49 731 500 24981 [email protected] +49 731 500 24979


Dr. Bernd Neumaier Head of PET Chemistry


Dr. Andreas Vogg, Radiochemist Christoph Solbach, Radiochemist Dr. Michaela Schmid, Chemist

[3] TYPE OF


INSTALLATION 1994

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 40 20 Typical beam employed (µA) 30 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) 20






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Research, still not specified. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Munich, Nuklearneclizimsche

und Polikline, KRI & in cases of cyclotron maintenance

Yes No


Yes No

e.g. with FLP, FDOpa [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number



[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience?

The candidate can only visit our cyclotron site, self-operation is impossible. Yes No

143

138


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 50 95 2 600 Yes No

20Ne (d, α) 18F 6 21 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 22 4/week Yes No Yes No Dopa 0.8 2/week Yes No Yes No FLT 3 1/week Yes No Yes No Fluoride 6 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 7 2/week Yes No Yes No Acetate 2.5 2/week Yes No Yes No Raclopride 4 2/week Yes No Yes No PK11195 1 0-1/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonic 16 0/week 16O(p,α) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 8 0/week 14N(din) OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 18F micliosides by electrophilic fluorination. 0.4GBq, occasionaly for research 11C chlorine, 6GBq/batch, 0.1/week 11C alpha-methyl-tryptophane, 1.5 GBq/batch, 0.1/week 11C carfentanil, 4GBq/batch, 0-1/week 11C flumazenile, 4GBq/batch, 0.1/week.

144

139


[1] INSTITUTE: Universitätsklinikum Ulm Abteilung Nukleamedizin Robert-Koch-Strasse 8 D-89081 Ulm


+49 731 500 24981 [email protected] +49 731 500 24979


Dr. Bernd Neumaier Head of Cyclotron / Radiopharmacy


Dr. Andreas Vogg, Radiochemist Wolfgang Scheel, Cyclotron Engineer Dr. Michaela Schmid, Chemist

1994 TYPE OF


INSTALLATION 07 / 2002

MANUFACTURER: GE Medical Systems. (II) UPGRADE: MODEL: PETtrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 30 Typical beam employed (µA) 35 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

25 h 20 h 5 h 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) Radpharm 25






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Research, still not specified. [9] Do you supply radionuclides to other institutions?



Yes No

e.g. with FLP, FDOpa [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number

511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 3 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience?

The candidate can only visit our cyclotron site, self-operation is impossible. Yes No

145

140


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 60 95 2 600 Yes No

20Ne (d, α) 18F 10 21 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 26 4/week Yes No Yes No DOPA 0.8 2/week Yes No Yes No Fluoride 6 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 7 2/week Yes No Yes No Choline 9 9/week Yes No Yes No Raclopride 2 1/week Yes No Yes No BTA-1 2 2/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonic 16 0/week 16O(p,α) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 8 0/week 14N(d,n) OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 11C alpha-methyl-tryptophane, 1.5 GBq/batch, 1/week

146

141

COUNTRY: GERMANY GER-21 [1] INSTITUTE: University of Frankfurt

Department of Nuclear Medicine Klinikum der Johann Wolfgang Goethe-Universität Theodor-Stern-Kai 7, Jaus 21 D D-60590 Frankfurt am Main


+49 69 6301 4330 [email protected] +49 69 6301 6805


Professor Dr. Frank Grünwald Chairman and Director


Professor Dr. Christian Menzel, Deputy Director

[3] TYPE OF

CYCLOTRON:


2002

MANUFACTURER: (II) UPGRADE: MODEL: PetTrace? [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





147

142


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced

148

143


[1] INSTITUTE: Westfaelische Wilhelms Universitaet Klinik und Poliklinik fuer Nuklearmedizin Domagkestrasse 5 48189 Münster


+49 251 83 473 76 or 473 62 [email protected] +49 251 83 473 63


Professor Dr. O. Schober Director


Jörg Eckardt, Physicist Dr. Markus Knickmeier, Chemist

[3] TYPE OF



MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

11 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 10 Radiography:












Yes No





149

144


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 97 1.1 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 2 weekly 15N(p,n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


150

145


[1] INSTITUTE: Zentralklinik Bad Berka GmbH Bad Berka PETCT Centre Robert-Koch-Allee 9 99437 Bad Berka, Germany


+49 364 585 2200 [email protected] +49 364 585 3515


Professor Dr. Richard P. Baum Chairman, Department of Nuclear Medicine/Centre for PETCT


Dipl.-.Ing. R. Wortmann, Head of Radiopharmacy

[3] TYPE OF



MANUFACTURER: CTI, Inc. (II) UPGRADE: 1998/99 (Dual Beam) MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week

16

h/week for radionuclide

production

14 - 15

h/week for

research

none

h/week for

maintenance

1-2

h/week for

applications

none

Installation underway [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: none Radiography: none

Materials science: none Proton therapy: none

Physics: none Neutron therapy: none

Activation analysis: none Other (specify) none






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 13N, 15O, 18F [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals in Germany, daily Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals caried out on-site?

Yes No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



151

146


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F > 3.4 GBq/µA 34 - 120 GBq

> 95 0.8 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 - 70 daily Yes No Yes No 18Fluoride 20 2/week Yes No Yes No 18FET (Tyrosin) 4 1/week Yes No Yes No 18FECh (Cholin) 4 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

None Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

None Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

None OTHER ISOTOPES PRODUCED

None Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


Ga-68 DOTA-NOC, Y-90 DOTA-TATE, Lu177-DOTA-TATE N-13 ammonia

152

147

14. HUNGARY

2005 COUNTRY: HUNGARY HUN-1

[1] INSTITUTE: Institute of Nuclear Research of the Hungarian Academy of Sciences Bem ter 18/c, P.O. Box 51


+36 52 417 266 +36 52 416 181


F. Tarkanyi Head, Cyclotron Department


Dr. L. Trón, Head of PET Centre Z. Kormany P. Kovacs

[3] TYPE OF

CYCLOTRON: Compact isochronous YEAR OF: (I)

INSTALLATION 1985

MANUFACTURER: NIIEFA Russia (II) UPGRADE: 1997 MODEL: MGC 20E [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 26 20 Yes No Maximum beam available (µA) 200 300 50 50 Typical beam employed (µA) 50 50 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

94 28 (56 every 2nd week) 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 13N-Ammonia, 15O-Water, 11C-Flumezinil, 111In-DTPA, 123I-mIBG, 123I-Imoazine [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Na123

I-every 2 weeks; 67

Ga-citric

acid – every 2 weeks.

Yes No


Yes No


511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



153

148


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): Neutron source (radiobiology, radiation hardness test, neutron activation, Thin Layer Activation (TLA), wear measurements, activation analysis (charged particle) Basic nuclear physics (in beam nuclear spectroscopy, astrophysical nuclear reactions)

154

149

15. INDIA

2005 COUNTRY: INDIA IND-1

[1] INSTITUTE: Radiation Medicine Centre Bhabha Atomic Research Centre (BARC) Trombay, Mumbai 400 085


+91 22 550 5326 [email protected] +91 22 550 5326


Dr. A.M. Samuel Director, Bio-Medical Group, BARC, Mumbai Dr. N. Ramamoorthy Chief Executive, BRIT, Mumbai


Dr. B.N. Karkers, Head, MD & PDS Dr. M.R.A. Pillai, Head, Radiopharmaceuticals Division Dr. N. Nair, Head, Radiation Medicine Centre

[3] TYPE OF

CYCLOTRON: Medical YEAR OF: (I)

INSTALLATION 2001

MANUFACTURER: Wipro GE, Mumbai (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: Dual particle (16.5 MeV Proton and e MeV Deuteron) 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

10-12 10-12 Not yet decided [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions? If yes and available, name of

institution/s & how often? Planned to supply 18

F to Nuclear Medicine Departments Yes No


Yes No


511 KeV coincidence Gamma camera 4 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



155

150


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

This is the first facility to be set up in the country with expertise in accelerations, radiopharmaceuticals, radiation biology and nuclear medicine. It is anticipated that apart from the routine PET radiopharmaceuticals, research in the development of new PET labeled compounds will be initiated.

156

151

2005 COUNTRY: INDIA IND-2

[1] INSTITUTE: Variable Energy Cyclotron Centre (VECC) 1/AF, Bidhan Nagar Calcutta - 700 064


+91 33 3371 230 +91 33 3346 871


Dr. B.C. Sinha Director


[3] TYPE OF

CYCLOTRON: Sector-focused (pole diameter 224 cm)

YEAR OF: (I)

INSTALLATION 1997

MANUFACTURER: VEC Centre (II) UPGRADE: MODEL: (Individual design) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6.30 12.30 25.80 Yes No Maximum beam available (µA) 200 200 200 Typical beam employed (µA) 20 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Regional Radiation Medicine

Centre, Thakurpukur, Calcutta – weekly, Radiation Medicine Centre Mumbai - monthly

Yes No


Yes No





157

152


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


158

153

16. INDONESIA

2005 COUNTRY: INDONESIA INS-1

[1] INSTITUTE: National Atomic Energy Agency, BATAN PPR-Batan Kawasan Puspiptek Serpong 15310


+21 756 3141 [email protected]


Mr. Silakhuddin Head, Cyclotron Division


Mr. Tonny Heryanto Budi Tarigan

[3] TYPE OF

CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1990

MANUFACTURER: CTI, Inc. (II) UPGRADE: 1995 (modified to negative ion by IBA)

MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24-27 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): We would like to produce 123I. Unfortunately we have no experts and facility. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals, 1-2/week Yes No


Yes No





159

154


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 1/2week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

We are planning to produce 18FDG in 2002.

160

155

17. IRAN, ISLAMIC REPUBLIC OF

COUNTRY: IRAN IRA-1

[1] INSTITUTE: Nuclear Research Centre for Agriculture and Medicine (NRCAM) P.O. Box 31585-4395, Karaj


+98 261 313 0676 +98 261 411 105


Professor Hossein Afarideh


Satari; Partovi Rafii; Akbari; Shafiei

[3] TYPE OF


INSTALLATION 1995

MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 7-15 Yes No Maximum beam available (µA) Typical beam employed (µA) 500 150 175 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-25 12-17 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 81mKr – Rb generator, 18F – FDG , 123In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To all nuclear medicine centres – Once a week

Yes No


Yes No





161

156


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 0.1 0.5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 0.5 0.5/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 0.037 1/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

162

157

18. ISRAEL

2005 COUNTRY: ISRAEL ISR-1

[1] INSTITUTE: Hadassah Medical Organization Ein Karem Il-91 120 Jerusalem


+972 2 6777 197 [email protected] +972 2 6438 506


Dr. Eyal Mishani Head of Cyclotron Unit


Mr. Desideriu Laky, Cyclotron Operator Dr. Revital ben-Daniel, Research Mr. Daniel Wajnblum, Engineer

[3] TYPE OF


INSTALLATION 1997


production

h/week for

research

h/week for

maintenance

h/week for

applications

18 12 6 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 4 Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, DOPA, 18F – FES; 18F –FLT; 11C – Choline ; 15O - Water [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence 2 Gamma camera 2 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



163

158


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 110 97 2.3 900 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 50 2-3/day Yes No Yes No Dopa Yes No Yes No ML 01 Yes No Yes No ML 03 Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline 10 Yes No Yes No Deprenyl 3 Yes No Yes No Methionine Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 8 16O(p,α ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 4 -8 1/week 14N (d, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


164

159

2005 COUNTRY: ISRAEL ISR-2

[1] INSTITUTE: Soreq NRC 81800 Yavne


+97 2 8943 4615 [email protected] +97 2 8943 4133


Engineer Yosef Shohet Head of Facility


Dr. M.B. Goldberg, Head, Steering Committee Dr. D. Berkovits, Chief Physicist Bs. Phrm. B. Hoch, Chief Radiochemist Mr. T. Arbel, Head of Operation Staff

[3] TYPE OF

CYCLOTRON: Cyclone series YEAR OF: (I)

INSTALLATION 2000

MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-25 15-20 1-2 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 15-20 Radiography:

Materials science: 1-2 Proton therapy:








[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C 66-68Ga 15F-DOPA [9] Do you supply radionuclides to other institutions?



Yes No





165

160


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15000 94 2 600 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 50 1-2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


166

161

19. ITALY

2005 COUNTRY: ITALY ITA-1

[1] INSTITUTE: Azienda Ospedaliero Universitaria Policlinico S. Orsola - Malpighi Via Massarenti, 9 40138 Bologna


+39 051 636 3952 [email protected] +39 051 636 3954


Professor Roberto Franchi Professor of Nuclear Medicine


Dr. Mario Marengo, Medical Physicist, Head Nuc. Med. Physics Dr. Stefano Boschi, Chemist, Head Radiopharmacy

[3] TYPE OF

CYCLOTRON: PETtrace YEAR OF: (I)

INSTALLATION 2001

MANUFACTURER: GE (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 38 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? Hospitals of Cesena and Forlì,

daily

Yes No


Yes No





167

162


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 100 >95 1.5 1000 Yes No

20Ne (d,α) 18F 5.5 Ne+0.3 %F2 60 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F - FDG 50 2/day Yes No Yes No 18F - FDOPA 1 1 / week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C - Choline 26 1 / day Yes No Yes No 11C - Methionie 26 1 / week Yes No Yes No 11C - acetate 26 1 / week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


168

163


[1] INSTITUTE: Azienda Ospedaliera 5. Maria Nuova Servizio di Medicina Nucleare V. le Risorgimento 80, Reggio Emilia


+39 0522 296 284 [email protected] +39 0522 296 392


Dr. Diana Salvo Department Chief


Dr. Annibale Versari chair of PET-Center activities

[3] TYPE OF

CYCLOTRON: 10 Mev YEAR OF: (I)

INSTALLATION October 2001

MANUFACTURER: General Electric (II) UPGRADE: MODEL: Minitrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Maybe 11C [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? In 2002 Yes No


Yes No





169

164


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 95 0.8 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 37 1or 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


170

165


[1] INSTITUTE: CNR Institute of Clinical Physiology Via Moruzzi, 1 I-56100 Pisa


+39 050 315 3384 [email protected] +39 050 315 2166


Piero A. Salvadori Head – PET/Cyclotron Facility


Luca Menichetti, Radiopharmacist Debora Petroni, Radiopharmacist Michela Poli, Pharmacist

[3] TYPE OF


INSTALLATION 1996

MANUFACTURER: GE Medical Syst. (II) UPGRADE: 2001 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 5 beam ports used (6 available); targets resident on beam ports, no beam

transport lines. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.7 8.4 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 1 –Small animal planned –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



171

166


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 55 97 1 150 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 11 1/day Yes No Yes No Fluoride 3.7 2/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methyl iodide 37 Development Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2 1/day Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

O Development Water Development OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Development Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Development Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Development Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Additional activities planned for near future:

- use of cyclotron for research in Boron neutro capture therapy

- FDG manufacturing site

- research in molecular imaging applied to genomic and proteonomic.

172

167


[1] INSTITUTE: Consiglio Nazionale delle Ricerche Institute Pascale (CNR) Via M. Semmola I-80131 Napoli


+39 81 5903 528/527 +39 81 5465 797


Professor Marco Salvatore


Antonello Green

[3] TYPE OF


INSTALLATION 1991

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water , 11C – CH3 I [9] Do you supply radionuclides to other institutions?



Yes No





173

168


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


174

169

2005 COUNTRY: ITALY ITA-5 [1] INSTITUTE: Istituto Naziónale per lo Studío e la Çura dei Tumori

Via G. Venezian 1 I-20133 Milano


+39 2 2390 2220 [email protected] +39 2 2367 874


Dr. Emilio Bombardieri Director, Nuclear Medicine Department


Dr. Flavio Crippa, Co-ordinator, Clinical PET Dr. Claudio Pascali, Co-ordinator, Radiopharmacy Eng. Vinicio De Sanctis, Responsible for the Cyclotron

[3] TYPE OF


INSTALLATION 1995

MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) PET 35







institutions?


Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 9-10 patients/day –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



175

170


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 4500 94-97 ~ 1 250 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 10-15 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 2 - 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


176

171

2005 COUNTRY: ITALY ITA-6 [1] INSTITUTE: Istituto Scientifico H. San Raffaele

Servizio di Medicina Nucleare Via Olgettina, 60 I-20132 Milano




Professor Ferruccio Fazio


Mario Matarrese Francesco Perugini Sergio Todde

[3] TYPE OF


INSTALLATION 1988

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: Negative hydrogen ions 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











institutions?


Yes No


Yes No


511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 3 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



177

172


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 26 > 94 0.65 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methyl choline 3 2/week Yes No Yes No FE – CIT 1 2/week Yes No Yes No Raclopride 1.5 1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 370 MBq 3/week 15N (p, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


178

173


[1] INSTITUTE: Ospedale San Raffaele, Universita Degli Studi Cattedra di Medicina Nucleare Via Olgettina 60 I-20132 Milano


+39 2 2153056/2643/ 2716 [email protected] +39 2 2640390


Professor Ferruccio Fazio


Mario Matarrese, in charge of the Cyclotron Francesco Perugini, in charge of Operations Sergio Todde, in charge of Radiochemistry

[3] TYPE OF


INSTALLATION 2000

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: Protons and deuterons beam. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











institutions?


Yes No


Yes No


511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 3 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



179

174


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 74 >94 2 700 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 37 1 run/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


180

175

2005 COUNTRY ITALY ITA-8 [1] INSTITUTE: European Commission – Joint Research Centre

Institute for Health and Consumer Protection Via E. Fermi 1, I-21020 Ispra (VA), Italy


+39-0332-785194 [email protected] +39-0332-789385


Uwe Holzwarth Technical Director


Kamel Abbas Neil Gibson

[3] TYPE OF


Compact Scanditronix MC40


1982 none to accelerator; laboratory continuous


Beam energies (MeV) 8-39 4-19.5 11-53 8-39 Yes No X Maximum beam available (µA) 60 50 20 30 Typical beam employed (µA) 30 15 3 5 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

70 35 20 5 10 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 0 Radiography: 0



Activation analysis: 5 Other (Target developm.) 10








Istituto Nazionale di Fiscica Nucleare according to common project necessities Istituto Europeo di Oncologia (start envisaged for 2006) [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No X


511 KeV coincidence 0 Gamma camera 0 Single photon tomography (SPET) 0 Positron emission tomography (PET), (PET-CT) 0 –Clinical 0 –Small animal 0 –Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes X No [14] Is the cyclotron used for targetry development? Please, specify. Yes X No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes X No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

181

176


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 100 95 1.5 ml Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 50 Yes No X Yes X No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu < 1 2/month Yes X No Yes X No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At < 1 1/month Yes X No Yes X No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F-FDG production in collaboration with commercial partner that is in charge with distribution (commercial data confidential) proton therapy: test and development of beam diagnostic equipment in collaborations 64Cu and 211At: target development, alternative production routes, production capacity will increase Distribution of 64Cu and 211At to collaboration partners in the nuclear and medical field for in vitro (later in vivo) studies; studies with 211At have to start in our labs due to missing licenses for handling alpha-emitters in hospitals CPAA for biokinetics studies on radioactive fallout components TLA for release studies on biomedical materials and implants, as well as engine components

182

177

2005 COUNTRY ITALY ITA- 9 [1] INSTITUTE: U.O.Medicina Nucleare centro PET

Ospedale S.Giacomo via Ospedale n° 18 31033 Castelfranco Veneto Treviso, ITALY


+390423732435 [email protected] +390423732426


F.Chierichetti MD director of Nuclear Medicine Department Head of PET center


Dr A.Fini, radiochmist Dr M.Marcolin, radiopharmacist

[3] TYPE OF


11 MeV CTI RDS 112


1994 2002

[4] CYCLOTRON CHARACTERISTICS: MEDICAL CYCLOTRON NEGATIVE IONS ACC. 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 10.5 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 28 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications




Activation analysis: Other (specify) Clinical






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18RFbFLT 18F MISO 18F DOPA [9] Do you supply radionuclides to other institutions?


2 other regional institutios [10] Are clinical medical research using cyclotron radiopharmaceuticals carried out on-site? Yes X No [11] Type of imaging equipment available on-site Number of

511 KeV coincidence 0 Gamma camera 0 Single photon tomography (SPET) 2 Positron emission tomography (PET), (PET-CT) 1 PET – Clinical, Small animal, Plant biochemistry 1 PET-TC [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No X

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No X [14] Is the cyclotron used for targetry development? Please, specify. Yes No X [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes X No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

183

178


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 >95 0.85 ml 800 gr Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 21 daily Yes X No Yes No X Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-Acetate 5 Twice a week Yes X No Yes No X Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N-Ammonia 1.1 Twice a week 16O ( p alfa )13N Yes No X Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 5.5 rare 15N (p n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

184

179


[1] INSTITUTE: Ospedale Maggiore di Milano Servizio di Medicina Nucleare Via Francesco Sforza 35 Pad. Granelli, I-20133 Milano


+39 02 5503 3340 +39 02 5503 5510


Dr. Paolo Gerundini Gherardi Primario


Fabio Riccardo Colombo Rosangela Casati

[3] TYPE OF

CYCLOTRON: PET Trace YEAR OF: (I)

INSTALLATION 2000

MANUFACTURER: (II) UPGRADE: MODEL: PT GEMS [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) PET






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water, 13N - Ammonia, 11C - Radiopharmaceuticals to be decided. [9] Do you supply radionuclides to other institutions?



Yes No





185

180


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 44.4 95 1.2 400 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 22.2 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


186

181

2005 COUNTRY ITALY ITA-11 [1] INSTITUTE: Istituto Clinico Humanitas

Via Manzoni 56 20089 Rozzano (MI), Italy


+390282246622 [email protected] +390282246691


Arturo Chiti Director, Nuclear Medicine


Giovanni Tosi / Physicist Katia Marzo/ Senior Radiochemist Mauro Almangano / Junior Radiochemist


Cyclone IBA Cyclone 18/9


2003

[4] CYCLOTRON CHARACTERISTICS: PROTON BEAM 18 MEV DEUTERON BEAM 9 MEV 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) 30 25 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

12 12 [6] Cyclotron applications: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-choline; 11C-metionine; 13N-ammonia [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET), (PET-CT) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Please, specify. Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

187

182


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 95 2000 µl 600 µl

Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 14.8 2 / DAY Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


188

183

2005 COUNTRY ITALY ITA-12 [1] INSTITUTE: AZIENDA OSPEDALIERA S. CROCE E CARLE - CUNEO

Via M Coppino 26 12100 Cuneo , Italy


+39.0171.64.1690 [email protected] +39.0171.64.1554


Dr. Alberto Biggi Head of Nuclear Medicine Dept


Dr. Gianni Perno, Physicist Dr. Michelangelo Longo, Chemist Ing. Roberto Giuliano. Chemist

[3] TYPE OF


Self-shielded GE Healthcare MINItrace


2002 -


Beam energies (MeV) 9.6 Yes No X Maximum beam available (µA) 35 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications




Activation analysis: Other (specify) Medical






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-Choline [9] Do you supply radionuclides to other institutions?



Yes X No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 5 Positron emission tomography (PET), (PET-CT) – Clinical 1 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


Yes No X

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No X [14] Is the cyclotron used for targetry development? Please, specify. Yes No X [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes X No [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

189

184


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 45 97 1 cc 300 Yes No X

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 25 1/die Yes X No Yes No X Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NH3 1 1/week 16O (p, α) 13N Yes No X


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


190

185

2005 COUNTRY ITALY ITA-13 [1] INSTITUTE: A.O. CANNIZZARO

VIA MESSINA 829 95126 CATANIA (ITALY)


++ 30 095 7263588 [email protected]


Dr. M. Ippolito MD/ head of Pet-Cyclotron Division


MG SABINI MEDICAL PHYSICIST F. SCOPELLITI RADIOCHEMISTRY P. DIRAIMONDO RADIOCHEMISTRY

[3] TYPE OF

CYCLOTRON: MANUFACTURER:MO

DEL:

IBA Cyclone 18/9


2004


Beam energies (MeV) 18 9 Yes x No Maximum beam available (µA) 80 35 Typical beam employed (µA) 40 20 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

12 7 N/A N/A N/A [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C- Methyoinine and Coline [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes x No

in next future [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No x


511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) Positron emission tomography (PET), (PET-CT) 2 (1+1) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? Yes No x

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No x [14] Is the cyclotron used for targetry development? Please, specify. Yes No x [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No x [16] Does your institute accept IAEA research fellows for training/experience? Yes No COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

191

186


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1500mCi 95% x 100% Yes x No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 900 mCi daily Yes x No Yes No x Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No

192

187

20. JAPAN

2005 COUNTRY: JAPAN JAP-1

[1] INSTITUTE: Biomedical Imaging Research Centre Fukui Medical University 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui, 910-1193


+81 776 61 8430 [email protected] +81 776 61 8170


Yoshiharu Yonekura Director, Professor of Medical Imaging


Yasuhisa Fujibayashi, Professor of Molecular Imaging Tatsuo Ido, Professor of PET Engineering

[3] TYPE OF

CYCLOTRON: OSCAR 5, superconducting, negative-ion RDS eclipse, negative-ion


1994

MANUFACTURER: NKK CMI/CTI

(II) UPGRADE: 2004

MODEL: Oxford RD/HP

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12

11 Yes No

Yes No Maximum beam available (µA) 50 - 40 Typical beam employed (µA) 30 - 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No 18F — 0.5/week




[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions? If yes, name of institutions. Yes No [10] Are clinical& medical research using cyclotron radiopharmaceuticals carried out on-site? Yes No [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number

511 KeV coincidence Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) –Clinical, Small animal, Plant biochemistry 2 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



193

188


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 96 4.2 1.5

800 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 20 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 1/month 16O(p,α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 0.37 2/week 15N(p,n) 15O CO CO2 O2

0.37 0.37 0.37

1/week 1/week 1/week

15N(p,n) 15O 15N(p,n) 15O 15N(p,n) 15O


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 0.37 1- 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 64Cu - ATSM (Hypoxia), 62Cu - ATSM (Hypoxia), 67Cu - PTSM (Perfusion) and 18F - FES (Estrogen receptor)

194

189

2005 COUNTRY: JAPAN JAP-2

[1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd. 453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592


+81 479 86 4721 [email protected] +81 479 86 5112


Mr. Takashi Syogenji Manager, RI Production Group


Yasuharu Sato

[3] TYPE OF


INSTALLATION 1991

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



195

190


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 5/week Yes No Yes No 124I Yes No Yes No 201Tl 1/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

196

191

2005 COUNTRY: JAPAN JPN-3

[1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd. 453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592


+81 479 86 4721 [email protected] +81 479 86 5112


Mr. Takashi Syogenji Manager, RI Production Group


Yasuharu Sato

[3] TYPE OF


INSTALLATION 1984

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



197

192


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 4/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

198

193


[1] INSTITUTE: Department of Radiology University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113


+81 3 381 55411 ext. 5129 +81 3 5800 8935


Toshimitsu Momose, MD Assistant Professor


Shinya Oku

[3] TYPE OF


INSTALLATION 1988

MANUFACTURER: Sumitmo Heavy Industries, Ltd.

(II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) PET clinical

applications









Yes No





199

194


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No DOPA Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

NHSP Yes No Yes No NHPB Yes No Yes No Methionine Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammpnia Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

O2 CO2 Water CO


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


200

195


[1] INSTITUTE: Gunma University School of Medicine 39-15 Showa-machi 3-chome Maebashi-shi, Gunma-ken 371




Professor Keigo Endo Chairman


Tomio Inoue, M.D. Kunio Matsubara, PhD. Katsumi Tomiyoshi, PhD.

[3] TYPE OF


INSTALLATION 1983


(II) UPGRADE:

MODEL: BC 1700 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

16 10 5 0.5 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0.5 Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α- Methyl - Tryptophan, 11C – Annexine [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No


511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



201

196


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 4 -5 60 2.0 50 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 4 -5 5/week Yes No Yes No FAMT 4 1/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline 10 - 15 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 10 1/month 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

O2 21 1/week 15N(p, n) 15O Water 10 1/month 15N(p, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


202

197


[1] INSTITUTE: HIMEDIC Imaging Center at Lake Yamanaka 562-12 Yanagihara, Hirano Yamanakako-mura, Minamitsuru-gun


+81 555 65 9135 [email protected] +81 555 20 3007


Dr. Michiru Ide President

OTHER SENIOR STAFF: [3] TYPE OF


INSTALLATION 1993

MANUFACTURER: Sumitomo Heavy Industries, Ltd.

(II) UPGRADE:

MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes N Maximum beam available (µA) 70 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





203

198


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 29 94 1.3 450 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 3 20/week 16O(p,α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


204

199


[1] INSTITUTE: Hokkaido University, Graduate School of Medicine Department of Tracer Kinetics Kita 15 Nishi 7 Kita-ku, Sapporo 060-8638


+81 11 706 5150 [email protected] +81 11 706 7155


Nagara Tamaki Professor and Chairman


Yuji Kuge, Associate Professor

[3] TYPE OF


INSTALLATION 1998


(II) UPGRADE:

MODEL: CYPRIS-HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes N Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C - NHSP, 18F DOPA, 11C Palmitic Acid , 11C CGFI 2177 [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No


511 KeV coincidence 2 Gamma camera Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



205

200


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 50 95 1.8 240 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 8 2/week Yes No Yes No Methyonine 7 1/week Yes No Yes No Flumazenil 5 1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2 Occasionally 16O(p,α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 1.5 2/week 14N(d,n) 15O O2 0.5 2/week 14N(d,n) 15O CO CO2

2.0 1.0

3/week 2/week

14N(d,n) 15O 14N(d,n) 15O


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

206

201


[1] INSTITUTE: Hyogo Institute for Aging Brain and Cognitive Disorders 520 Saisho-ko, Himeji Hyogo 670


+81 792 95 5511 [email protected] +81 792 95 8199


Dr. Masahiro Sasaki Chief, Nuclear Pharmacology Laboratory


[3] TYPE OF

CYCLOTRON: Superconducting negative ion cyclotron

YEAR OF: (I)

INSTALLATION 1992

MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR-2 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C MPHA [9] Do you supply radionuclides to other institutions?



Yes No





207

202


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15 50 5 25/ 95% Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 4 2 - 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 2 - 3/year Yes No Yes No NMSP 2 - 3/year Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 5 6 - 10/week 13N(p, n ) 15O O2 5 2 - 5/month 13N(p, n ) 15O CO 5 2 - 5/month 13N(p, n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


208

203


[1] INSTITUTE: Institute for Biofunctional Research 5-7-1 Fujishiro-dai, Suita-shi Osaka 565


+81 6 834 7000 [email protected] +81 6 872 8761


Dr. Naoto Hashimoto Director


Norimasa Ejima

[3] TYPE OF


INSTALLATION 1992


(II) UPGRADE:

MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 25 20 Typical beam employed (µA) 15-20 10-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

~24 810 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:











[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Specific to animal PET studies.

Yes No





209

204


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C - N2 40-50 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N – H2

16O+5mM EtOH

1.7 1 per 3 months Yes No


(list)


used

Price/

GBq 15O – N2+O2 (0.4%)

7.5 (2-3) × (5-7)


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


210

205


[1] INSTITUTE: International Medical Centre of Japan Radiology Department 1-21-1 Toyama, Shinjaku-ku


+81 3 3202 7181 [email protected] +81 3 3202 7181


Toshihiko Hara, MD Chief - Nuclear Medicine


Noboru Kosaka, MD

[3] TYPE OF


INSTALLATION 1994


(II) UPGRADE:

MODEL: BC 2010N [4] CYCLOTRON CHARACTERISTICS: p.d. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 1 Yes No Maximum beam available (µA) 50 30 Typical beam employed (µA) 30 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





211

206


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 18.5 70 2 260 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 7.4 Yes No Yes No Choline 3.7 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline 14.8 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 3.7 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


212

207


[1] INSTITUTE: Japan Atomic Energy Research Institute (JAERI) 1233 Watanuki, Takasaki Gunma 370-1292


+81 27 346 9420 [email protected] +81 27 346 9688


Dr. Toshiaki Sekine Deputy Director Department of Radiation Research for Environment and Resources


Ms. Noriko Shigeta Ishikoka Mr. Sutoshi Watanabe

[3] TYPE OF

CYCLOTRON: AVF Cyclotron, K-110

YEAR OF: (I)

INSTALLATION 1990

MANUFACTURER: Sumitomo Heavy Industries

(II) UPGRADE:

MODEL: 930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 50 100 Yes No Maximum beam available (µA) 5 7 7 Typical beam employed (µA) 5 5 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

101 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 32 Radiography:



Activation analysis: Other (specify) 29,cyclotron

technology

development






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 76Br, 77Br [9] Do you supply radionuclides to other

institutions?


Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry 2 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



213

208


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


20Ne (d, α) 18F 16O (α, d) 18F 0.1 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 0.03 1/month Yes No Yes No 18F - WATER 0.1 2/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Mehionine 0.4 3/week Yes No Yes No CO2 3 8/week Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NO-3 0.3 15/week 16O(p,α) 13N Yes No


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Products with our cyclotron are used in plant physiology only. Once, we have produced 186Re for medical research. Production of this radionuclide, for medical purposes may be done again. Metallic positron emitters 48V, 52 Mn, 52 Fe and 62 Zn are also produced.

214

209


[1] INSTITUTE: Kanazawa Cardiovascular Hospital Ha 16 Tanaka, Kanazawa Ishikawa


+81 76 253 8000 [email protected] +81 76 253 0008


Mr. Toshihiko Morikawa


CYCLOTRON: Baby cyclotron for medical use

YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: The Japana Steel Works Ltd.

(II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

~ 20 ~ 4 ~ 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



215

210


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): ………

216

211

2005 COUNTRY: JAPAN JPN-13 [1] INSTITUTE: Kyoto University Hospital

54 Shogoin Kawahara-cho, Sakyo-ku Kyoto 606-8507


+81-75-751-3306 [email protected] +81-75-751-3217


Hidekazu Kawashima, PhD.


Mr. Haruhiro Kitano

[3] TYPE OF


INSTALLATION 1982


(II) UPGRADE: 1997 (change of electronic circuit)

MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other:

Radiopharmaceuticals for

clinical and animal studies

7






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [11C]SCH23390, [11C]CFT, [18F]FDOPA [9] Do you supply radionuclides to other institutions?



Yes No





217

212

18F Radionuclide production Production Typical

production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 97 4 200 Yes No

20Ne (d, α) 18F 17 16O (α, d) 18F 18F radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 16 140/year Yes No Yes No FLT 2.0 10/year Yes No Yes No Yes No Yes No Yes No Yes No 11C radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 2.0 12/year Yes No Yes No Flumazenil 2.5 4/year Yes No Yes No PK11195 1.0 6/year Yes No Yes No Yes No Yes No 13N radiopharmaceuticals produced Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Yes No 15O radiopharmaceuticals produced Name

(list)


used

Price/

GBq

CO 1.5/min 48/year 14N(d, n ) 15O O2 0.8/min 24/year 14N(d, n ) 15O CO2 0.5/min 24/year 14N(d, n ) 15O Other isotopes produced

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No Comments: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

218

213


[1] INSTITUTE: Kyushu University Department of Radiology, Faculty of Medicine Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582


+81 92 6425 788 +81 92 642 5833


Dr. Yasuo Kuwabara Chief, Nuclear Medicine Section


Masayuki Sasaki Isuyoshi Yoshida Toshimitsu Fukumura

[3] TYPE OF


INSTALLATION 1983


(II) UPGRADE: 1998


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





219

214


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 10 95 2 40 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 2/week Yes No Yes No DOPA Yes No Yes No Estiradiol Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 1/week Yes No Yes No Methionine 1/week Yes No Yes No NMPB 1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

H2O 1/week 14N(d, n ) 15O CO 1/week 14N(d, n ) 15O O2

CO2

1/week 1/week

14N(d, n ) 15O 14N(d, n ) 15O


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


220

215


[1] INSTITUTE: Medical School of Nagoya University Department of Radiology 65 Tsurumaicho, Showa-ku Nagoya City 466


+81 52 741 2111 or 733 9415


Mr. Masanori Tadokoro


Takeo Ishigaki Masanari Nishino

[3] TYPE OF


INSTALLATION 1989


(II) UPGRADE:


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



221

216


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 16 3 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C–Methionine 100 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15O-Water 100 1 per week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


222

217


[1] INSTITUTE: Nagoya City Rehabilitation and Sports Center 1-2 Mikanyama, Yatomi-cho Mizuho-ku, Nagoya 467-8622


+81 52 83 4573 [email protected] +81 52 835 3745


Yoshihiro Ito


Noriyuki Kato Katsumi Araki

[3] TYPE OF


INSTALLATION 1989


(II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 40 40 Typical beam employed (µA) 20 5 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C Raclopride , Na 18H [9] Do you supply radionuclides to other institutions?



Yes No





223

218


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1.8 1day/week Yes No Yes No DOPA 1 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

NMSP 2.5 5 days/year Yes No Yes No Methionine 2.5 3days/year Yes No Yes No Palmitic Acid 2.5 6 days/year Yes No Yes No Acetic Acid Flumazenil

2.5 2.5

6 days/year 1 day/month

Yes No Yes No

13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on batch

(GBq)


used

Price/

GBq

Water 4 days/week 14N(d,n )15O CO, CO2 & O2 1.5 days/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


224

219


[1] INSTITUTE: National Cardiovascular Centre 5-7-1 Fujishirodai, Suita Osaka 565


+81 6 833 5012 [email protected] +81 6 872 7486


Dr. Yoshio Ishida Director of Nuclear Medicine


Dr. Yoshinori Miyake

[3] TYPE OF

CYCLOTRON: AVF YEAR OF:



(II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 70 70 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 1 2 5 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 12










institutions?


Yes No


Yes No


511 KeV coincidence 3 Gamma camera 5 Single photon tomography (SPET) 5 Positron emission tomography (PET) –Clinical 2 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



225

220


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F In future

22 94 0.7 60 Yes No

20Ne (d, α) 18F 18.5 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1.5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 3.3 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.4 5/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 3.3 3- 9/week 14N(d, n ) 15O CO,CO2,O2 0.01 9/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


226

221


[1] INSTITUTE: National Centre of Neurology and Psychiatry 4-1-1 Ogawahigashi-cho 4-chome, Kodaira, Tokyo 187


+81 423 412 711 [email protected] +81 423 446 745


Dr. Hiroshi Matsuda Director, Radiological Division


Yutaka Takayama; Satoru Horikoshi Kenichi Ogawa; Masato Kobayashi

[3] TYPE OF

CYCLOTRON: Superconducting compact

YEAR OF: (I)

INSTALLATION 1997

MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR, SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 11.4 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





227

222


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 1-2 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15O-Water 18 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


228

223

COUNTRY: JAPAN JPN-19

[1] INSTITUTE: National Institute for Longevity Sciences Gengo, Morioka Obu 474-8522


+81 562 46 2311 [email protected] +81 562 44 6 596


Dr. Kengo Ito


Dr. Kentaro Hatano Dr. Takashi Kato

[3] TYPE OF

CYCLOTRON: Negative ion acceleration AVF

YEAR OF: (I)

INSTALLATION 1995


(II) UPGRADE:

MODEL: HM-18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications







F, 370MBq







Yes No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 1 –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



229

224


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 17 >93 2 80 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 2.4 1/week Yes No Yes No DOPA 0.875 1/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 0.37 24/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 17.4 30/year 14N(d, n )15O CO 3.7 5/year OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - SCH 23390 and B-CFT are used for animal experiments (including PET). Some novel radiopharmaceuticals are produced for drug development research.

230

225

2005 COUNTRY: JAPAN JPN-20 [1] INSTITUTE: National Institute of Radiological Sciences

Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku


+81 43 206 3262 [email protected] +81 43 206 3261


Dr. Kazutoshi Suzuki Head


Mr. Toshiaki Irie, Head Mr. Kiyoshi Fukushi, Senior Researcher Mr. Terushi Haradahira, Senior Researcher

[3] TYPE OF


INSTALLATION 2000


(II) UPGRADE:

MODEL: BC - 2010 BC-2010 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No for PET







Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 3 –Clinical –Small animal 2 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



231

226


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1 – 10 50 1.5 30 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 4 8/week Yes No Yes No McN5652X 1-2 3/week Yes No Yes No Raclopride 1-2 1/week Yes No Yes No MP4A 2 1/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2-3 1/week 16O(p,α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 2 6/week 14N(d, n )15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - Ro 15-1788, Ro 15- 4513, NMSP and SCH 23390

232

227


[1] INSTITUTE: National Institute of Radiological Sciences Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku


+81 43 206 3262 [email protected] +81 43 206 3261





[3] TYPE OF


INSTALLATION 1994


(II) UPGRADE:


production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No PET







Yes No





233

228


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1- 10 20 - 50 1.5 30 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1 – 10 1 - 2/week Yes No Yes No Labeled Compd. 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Ro15 - 4513 3 1 - 2/week Yes No Yes No Methionine 4 6/week Yes No Yes No WAY 100635 1 -2 2 - 3/week Yes No Yes No MP4A 1 - 2 1/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2-3 1/week 16O(p,α) 13N Yes No NPC 1 1/month Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 2 12/week 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, McN 5652X(+),McN 5652, Ro15 - 1788, SCH 23390, Raclopride, FLB 457, NMPB and Cyanoimipramine

234

229


[1] INSTITUTE: National Institute of Radiological Sciences Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku


+81 43 206 3262 [email protected] +81 43 206 3261





[3] TYPE OF

CYCLOTRON: AVF multi-particle YEAR OF: (I)

INSTALLATION 1973

MANUFACTURER: Thomson CSF (II) UPGRADE: MODEL: AVF-930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 55 145 110 Yes No Maximum beam available (µA) 20 20 10 10 Typical beam employed (µA) 20 15 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





235

230


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 1-10 20-50 1.5 30 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1-10 1-2/week Yes No Yes No Labeled Compd 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

WAY 100635 1-2 1-2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2-3 1/week Yes No NPC 1 1/month Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 2 6/week 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3 1/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, MCN 5652X(+), MCN 5652, RO15-1788, SCH 23390, RACLOPRIDE, FLB457, NMPB, CYANOIMIPRAMINE, 38K

236

231


[1] INSTITUTE: National Research Institute for Metals 1-2-1 Sengen, Tsukuba Ibaraki 305


+81 298 592 014 [email protected] +81 298 592 014


Mr. Johsei Nagakawa Group Leader


Mr. Norikazu Yamamoto, Subgroup Leader Mr. Yoshiharu Murase, Researcher Mr. Toshimitsu Fukuzawa, Researcher

[3] TYPE OF

CYCLOTRON: AVF (fixed energy) YEAR OF: (I)

INSTALLATION 1986


(II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 26 20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 30 30 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





237

232


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We use our cyclotron only for studying radiation damage in nuclear reactor materials and not for RADIONUCLIDE

PRODUCTION

238

233


[1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility 3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266


+81 438 634 771 +81 438 633 306


Dr. Masaji Takahashi Manager of Technical Section 1


[3] TYPE OF


INSTALLATION 1986


(II) UPGRADE:

MODEL: 750 PV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 130/55 Typical beam employed (µA) 120/50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? — everyday to hospitals. Yes No


Yes No





239

234


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 500(@EOB) 3/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb

240

235


[1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility 3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266


+81 438 634 771 +81 438 633 306


Dr. Masaji Takahashi Manager of Technical Section 1


[3] TYPE OF


INSTALLATION 1985


(II) UPGRADE: 1999 (H- acceleration)

MODEL: 480P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28 Yes No Maximum beam available (µA) 55 Typical beam employed (µA) 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? — everyday, to hospitals. Yes No


Yes No





241

236


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 300(@EOS) 5/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb

242

237


[1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility 9-1 Techno Park, Sanda City Hyogo Pref., 669-1339


+81 795 684 771 +81 795 683 071


Mr. Shigeaki Kataoka Manager of Technical Section 1


[3] TYPE OF

CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions

YEAR OF: (I)

INSTALLATION 1992

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes N Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? Everyday, to Hospitals

Yes No


Yes No





243

238


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

244

239


[1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility 9-1 Techno Park, Sanda City Hyogo Pref., 669-1339


+81 795 684 771 +81 795 683 071


Mr. Shigeaki Kataoka Manager of Technical Section 1


[3] TYPE OF

CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions


1990

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? Everyday, to Hospitals Yes No


Yes No





245

240


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

246

241


[1] INSTITUTE: Nikko Memorial Hospital Shintomi-cho 1-5-13 Muroran-shi, Hokkaido 51


+81 143 24 1331 +81 143 22 5296


Masahiro Shinohara Chief of Radiology


Takafumi Mochizuki, Radiology

[3] TYPE OF

CYCLOTRON: Deep valley fixed energy proton

YEAR OF: (I)

INSTALLATION 1996/7


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





[14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No


247

242


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 11 40% 1.1 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 3.7 1 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


248

243


[1] INSTITUTE: Nishidai Clinic Diagnostic Imaging Center, Inc. 1-83-8 Takashimadaira, Itabashi-ku Tokyo 175-0082


+81 3 5922 0700 [email protected] +81 3 5922 0701


Kimiichi Uno, M.D. Chairman


Keiichi Nakagawa, M.D. Katsumi Tomiyoshi, PhD., M.D.

[3] TYPE OF


INSTALLATION 2000


(II) UPGRADE:


production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α - Methyl Tyrosine (18F AMT) [9] Do you supply radionuclides to other institutions?



Yes No





249

244


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 95 2.0 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 10-15 1-2/day Yes No Yes No 18F 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

MET 5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 10 3/day 16O(p,α) ) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 5 1/week 13N(p, n) 15O CO, O2 & C O2 10 1/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced We carry out clinic diagnostic studies only, in collaboration with Gunma University School of Medicine.

250

245


[1] INSTITUTE: Nishijin Hospital 1035 Mizomae-cho, Kamigyo-ku Kyoto 602




Dr. Takahiro Kanatsuna President


Akira Fijii Hitoshi Horii Kazuo Wakita

[3] TYPE OF


INSTALLATION 1985


(II) UPGRADE:

MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 10 ~ 50 Typical beam employed (µA) 70 ~ 80 extracting

efficiency: (60 ~ 65%)

[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

6 ~10 6 ~10 4 ~ 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:











Yes No





251

246


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


252

247


[1] INSTITUTE: Nishina Memorial Cyclotron Centre 348-58 Tomegamori, Takizawa Iwate 020-0173


+81 19 688 6071 [email protected] +81-19 688 6072


Tsuneo Takahashi Director


Shoji Futatsugawa, General Manager Kouichiro Sera, Professor Satoru Hatakeyama, Manager

[3] TYPE OF


INSTALLATION 1989

MANUFACTURER: Shimazu (II) UPGRADE: MODEL: MCY 1750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.9 8.3 Yes No Maximum beam available (µA) 30 30 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





253

248


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 14.5 1 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Oxygen Carbon dioxide Water OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


254

249


[1] INSTITUTE: Osaka City University Medical School Division of Nuclear Medicine 1-4-3 Asahi-machi, Abenoku Osaka 545-8585




Dr. Hironobu Ochi Professor, Division of Nuclear Medicine


Dr. Masaji Okamoto Susumu Shiomi, Associate Professor

[3] TYPE OF

CYCLOTRON: Compact superconducting, negative ion

YEAR OF: (I)

INSTALLATION 1992

MANUFACTURER: Oxford-NKK (II) UPGRADE: 1993 MODEL: OSCAR SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





255

250


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 5 50 5 50 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5 15/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 5 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2 10/month Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

CO2 2 2/month O2 4 CO 4 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


256

251


[1] INSTITUTE: Research Institute for Brain & Blood Vessels Akita 6-10 Senshu-Kubota-machi Akita City


+81 188 330 115 [email protected] +81 188 332 104


Dr. Kazuhiro Takahashi Head


Masanobu Ibaraki

[3] TYPE OF


INSTALLATION 1983


(II) UPGRADE:

MODEL: BC-168 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











institutions?


Yes No


Yes No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



257

252


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 60 1.5 40 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 6 2/week Yes No Yes No 3NHPB 2 15/year Yes No Yes No NMSP 2 15/year Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

H2O 4 20/week 14N(d, n )15O O2 20 6/week CO 10 6/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


258

253


[1] INSTITUTE: Tohohu University Cyclotron and Radioisotope Center (CYRIC) Aramaki, Aoba-ku Sendai 980-7


+81 217 7798 [email protected] +81 263 5358


Professor Tsutomu Shinozuka


[3] TYPE OF

CYCLOTRON: AVF multi particle YEAR OF: (I)

INSTALLATION 1977


(II) UPGRADE:

MODEL: 680 AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 25 65 50 Yes No Maximum beam available (µA) 15 12 5 5 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

87 ~ 96 16 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





259

254


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 11 3-4 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine Yes No Yes No Doxepin Yes No Yes No Nemonapride Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water ~ 30 2 per week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


260

255


[1] INSTITUTE: Tokyo Metropolitan Institute of Gerontology 35-2 Sakaecho Itabashi Tokyo 173-0015


+81 3 3964 3241 ext. 3505 [email protected] +81 3 3964 2188


Dr. Kiichi Ishiwata Head, Positron Medical Center


Dr. Yuichi Kimura, Senior Research Scientist Dr. Toru Sasaki, Research Scientist Kenji Ishii, M.D., Research Scientist Keiichi Oda, Research Scientist

[3] TYPE OF

CYCLOTRON: AVF, positive ion YEAR OF: (I)

INSTALLATION 1990


(II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 24 (not

routinely used)

18 (not routinely used)

Yes No

Maximum beam available (µA) Typical beam employed (µA) 30 10 ~ 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





261

256


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine Yes No Yes No Flumazenil Yes No Yes No N-methyl spiperone

Yes No Yes No

Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Oxygen Carbon dioxide Carbon monoxide


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


262

257


[1] INSTITUTE: University of Tokyo Department of Radiology 7-3-1 Hongo Bunkyo-ku Tokyo 113


+81 3 3815 5411 ext. 5129 +81 3 5800 8678


Professor Johru Ontoke


Toshimitsu Momose Shinya Oku

[3] TYPE OF




(II) UPGRADE:

MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes N Maximum beam available (µA) Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 –Clinical –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



263

258


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine Yes No Yes No N-Methyl- spiperone

Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water Oxygen C. monoxide Carbon dioxide OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


264

259

21. KAZAKHSTAN

2005 COUNTRY: KAZAKHSTAN KAZ-1

[1] INSTITUTE: Institute of Nuclear Physics 480082 Almaty-82, Ibragimov str., 1


+7 327 2 546 433 [email protected] +7 327 2 546 517


Professor A.A. Arzumanov Head, Accelerator Laboratory


Sychikov Gennadi Popov Yuri Batischev Viktor

[3] TYPE OF

CYCLOTRON: Variable energy isochronous K=50 MeV

YEAR OF: (I)

INSTALLATION 1965

MANUFACTURER: Efremov Institute, Leningrad

(II) UPGRADE: 1972, converted to variable energy isochronous

MODEL: U 150 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-30 12-25 18.5-62 25-50 Yes No Maximum beam available (µA) 500 200 50 100 Typical beam employed (µA) 300 100 20 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 16.5 15.7 4.3 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:

Materials science: 1.8 Proton therapy:

Physics: 15.7 Neutron therapy:

Activation analysis: Other (specify) Neutron Source, 1.7



Co, (5)


Co, (1)


Co, (4) 109

Cd,(6)

Intense neutron beam? (specify average En = ?) Yes No 2 MeV

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl Chloride, 67Ga Citzate, 57Co, 109Cd, 111In, 237Pu, 88Y, 85 Sr [9] Do you supply radionuclides to other institutions?If yes and available, name of

institution/s & how often? Hospitals, central clinics, on request. Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical, Small animal, Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



265

260


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2

(l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 13 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 3.0 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 3.3 On request. Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

266

261

22. REPUBLIC OF KOREA

2005 COUNTRY: KOREA, REPUBLIC OF ROK-1

[1] INSTITUTE: Korea Cancer Centre Hospital Korea Atomic Energy Research Institute 215-4 Gongneung-Dong, Nowon-Ku, Seoul


+82 2 970 1331 [email protected] +82 2 970 1332


CHAI, Jong-Seo Principal Researcher/Director


KIM, Yu-Seok, Senior Engineer HONG, Seong-Seok, Engineer LEE, Min-Yong, Engineer

[3] TYPE OF


INSTALLATION 1987

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 50 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50 25 60 50.5 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 60 low current low current [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 20 6 [6] CYCLOTRON APPLICATIONS: 60 h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F production by 20Ne target; High purity 123I production by 124Xe target; on plan: 11C, 45Ti, 211At, 186Re, 124I [9] Do you supply radionuclides to other

institutions?

If yes and available, name of institution/s & how often? 67Ga-citrate, 201TICI, Na123I, 123I-mIBG – 1 per week

Yes No


Yes No





267

262


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


20Ne (d, α) 18F 16O (α,d )18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


268

263


[1] INSTITUTE: Korea Cancer Centre Hospital Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul


+82 2 970 1331 [email protected] +82 2 970 1332





[3] TYPE OF

CYCLOTRON: Proton only YEAR OF: (I)

INSTALLATION 2002

MANUFACTURER: IBA (II) UPGRADE: MODEL: Cyclone-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 200 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





269

264


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 1.5 2/week 15N(p, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


270

265


[1] INSTITUTE: Korea Cancer Centre Hospital Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul


+82 2 970 1331 [email protected] +82 2 970 1332





[3] TYPE OF


INSTALLATION 2001

MANUFACTURER: KIRAMS (II) UPGRADE: MODEL: KIRAMS -13 [4] CYCLOTRON CHARACTERISTICS: H+ 13 MeV, 4 sector magnet, 4th harmonics, PIG internal ion source, GUI

computer control. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): F-18, FDG [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? National Cancer Center; Ajou University Hospital, Yonsei University Hospital.

Yes No


Yes No


511 KeV coincidence 2 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



271

266


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


272

267


[1] INSTITUTE: Seoul National University Hospital Department of Nuclear Medicine 28 Yungun-Dong, Chongro-Ku Seoul 110-744


+82 2 760 3805 [email protected] +82 2 745 7690


Dr. Jae Min Jeong Director, Cyclotron and Radiochemistry; Associate Professor


In Won Lee, Chief Technologist

[3] TYPE OF


INSTALLATION 1994

MANUFACTURER: EBCO Technology (II) UPGRADE: MODEL: TR-13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? Yunsei University Hospital — 5/week; National Cancer Center — 2/week

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



273

268


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 18 97 0.5 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionine 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 1.5 2/week 15N(p, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


274

269


[1] INSTITUTE: Samsung Medical Centre Department of Nuclear Medicine Sungkyunkwan University School of Medicine 50 Ilwon-Dong, Kangnam-Ku Seoul 135-710


+82 2 3410 2623 [email protected] +82 2 3410 2639


Yearn Seong Choe Assistant Professor/Senior Research Scientist


[3] TYPE OF


INSTALLATION 1994

MANUFACTURER: GEMS (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 5/5 Positron emission tomography (PET) 1 – Clinical 1/1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



275

270


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 97 1.5 ~ 310 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 7 -11 6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

CFT Yes No Yes No Methionine 1/week Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia > 1.9 1/week 16O (p, α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water > 3.7 1/week 14N(d, n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


276

271


[1] INSTITUTE: Asan Medical Center Seoul


+82 2 2224 4590 [email protected] +82 2 2224 4588


Dr. Seung Jun Oh


CYCLOTRON: H-/D- YEAR OF: (I)

INSTALLATION 2001

MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 25 Typical beam employed (µA) 38 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-neuroreceptor imaging radiopharmaceuticals [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Two-three times in a week. Yes No


Yes No





277

272


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 185 95 2.0 480 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methonine 18.5 3-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 18.5 1-2/week 160 (p,a)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 18.5 1-2/week 14n(D,N)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


278

273


[1] Institute: Yonsei University Hospital Department of Nuclear Medicine 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752


+82 2 365 8441 +82 2 365 8437


Wan-won Seo


[3] TYPE OF

CYCLOTRON:

1H, 2H YEAR OF: (I)

INSTALLATION 2003

MANUFACTURER: IBA (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 100 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FDG [9] Do you supply radionuclides to other institutions?



Yes No





279

274


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


280

275


[1] INSTITUTE: NATIONAL CANCER CENTER Department of Nuclear Medicine 809 Madu1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do 411-769


+82 31 920 0176 +82 31 920 0179


Yong-keun, Kim Director


[3] TYPE OF


INSTALLATION 2001

MANUFACTURER: CTI (II) UPGRADE: MODEL: RDS111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FDG, 11C-acetate, FLT [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



281

276


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


282

277


[1] INSTITUTE: The Catholic University of Korea, Kangnam St. Mary's Hospital Department of Radio-pharmaceutical 505 Banpo-dong, Socho-gu, Seoul 137-701


+82 2 3478 1816 +82 2 3478 1819


Hee-cheol, Kim Director


[3] TYPE OF


INSTALLATION 2004

MANUFACTURER: CTI (II) UPGRADE: MODEL: RDS eclipse [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





283

278


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


284

279


[1] INSTITUTE: Kosin University Gospel Hospital Department of Cyclotron 34 Ahnnam-Dong,Seo-Ku Pusan 602-702




Sung-kwon Lee Director,


[3] TYPE OF


INSTALLATION 2004

MANUFACTURER: CTI (II) UPGRADE: MODEL: RDS eclipse [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





285

280


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


286

281


[1] INSTITUTE: Kyungbook National University Hospital 50 Samduk-2ga, Jung-gu Daegu, 700-721




[3] TYPE OF


INSTALLATION 2005

MANUFACTURER: KIRAMS (II) UPGRADE: MODEL: KIRAMS-13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





287

282


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


288

283


[1] INSTITUTE: Yeungnam University Medical Center Department of PET-CT 317-1 Daemyung-Dong, Nam-Ku Daegu 705-717


+82 53 620 3126 [email protected] +82 53 625 3126


Ssang-tae Kim Director,


[3] TYPE OF


INSTALLATION 2004

MANUFACTURER: GE (II) UPGRADE: MODEL: G.E MINItrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 35 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? Daegu Catholic University Hospital -5/week;

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 –Clinical 1 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



289

284


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


290

285


[1] INSTITUTE: Chonnam National Univeristy Hospital Department of Nuclear Medicine 8 Hak-dong, Dong-gu Gwangju 501-757


+82 61 379 7262 [email protected] +82 61 379 7281


Jeong-young Kim


[3] TYPE OF


INSTALLATION 2004

MANUFACTURER: GE (II) UPGRADE: MODEL: G.E PETtrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) 70 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FDG, Ammonia [9] Do you supply radionuclides to other institutions?



Yes No





291

286


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


292

287


[1] INSTITUTE: Eulji Univeristy Hospital Department of Nuclear Medicine 1306 Dunsan-Dong, Seo-Ku Daejeon 302-799


+82 42 259 1425


Mon-hyung Gu


[3] TYPE OF


INSTALLATION 2004

MANUFACTURER: Sumitomo (II) UPGRADE: MODEL: Cypris HM-12S

12/6MeV

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





293

288


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


294

289


[1] INSTITUTE: Chosun University Hospital 588 Seoseok-Dong,Dong-Ku Gwangju 501-717




[3] TYPE OF

CYCLOTRON: YEAR OF:

(I) INSTALLATION 2005 (Installing)

MANUFACTURER: KIRAMS (II) UPGRADE: MODEL: KIRAMS-13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No

Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





295

290


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GB q


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


296

291

23. MEXICO

2005 COUNTRY: MEXICO MEX-1

[1] INSTITUTE: Unidad PET, Facultad de Medicina Univesidad Nacional Autónoma de México Circuito Escolar S/N, Ciedad Universitaria Del. Coyoacán 04510 México, D.F.


+52 5623 22 88 or 5623 22 99 [email protected] +52 5623 21 15 or 5623 22 41


Dra. Nora E. Kerik Rotenberg Chief of Department


Dr. René Drucker Colín, Scientific Committee Member M. en C. Adolfo Zárate Morales, Cyclotron Operator M. en C. Martha Pedraza López, Radiopharmacist Q.F.I. Irma Martínez Hernández, Radiopharmacist Fís. Miguel Angel Avila Rodríguez, Cyclotron Operators

[3] TYPE OF

CYCLOTRON: YEAR OF:



production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - DOPA and Raclopride [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To hospitals in the future Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical, Small animal, Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



297

292


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 95-97 0.8 7 250 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

HCN 33.3 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 3.7 2/week 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 28 15N(p,n ) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


298

293

24. NETHERLANDS

2005 COUNTRY: NETHERLANDS NET-1

[1] INSTITUTE: Accrec B.V. Eindhoven University of Technology (TUE) Cyclotron Building Postbus 513, NL-5600 MB Eindhoven


+31 40 247 4048 [email protected] +31 40 243 8060


Professor Dr. M.J.A. de Voight/Professor Dr. M.J. u.d. Wiel Directors, Accrec B.V.


[3] TYPE OF


(I) INSTALLATION Planned during 2002

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18-30 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





299

294


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


300

295




+31 40 247 4048 [email protected] +31 40 243 8060




[3] TYPE OF

CYCLOTRON: 2nd harmonic dees with 6th harmonic flat top dees


1989

MANUFACTURER: Home-made (II) UPGRADE: MODEL: ILEC [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





301

296


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


302

297




+31 40 247 4048 [email protected] +31 40 243 8060




[3] TYPE OF


INSTALLATION 1963

MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3- 30 2-20 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

~ 80 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:

Materials science: Yes Proton therapy:


Activation analysis: Other (specify) Catalysis/

radiochemistry









Yes No


511 KeV coincidence 1 (PEP) Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



303

298


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C alkanes weekly Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NO 16O(p, α)13N Yes No Ammonia 16O(p, α)13N Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

N2 150 14N (d, n) 15O


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Commercial isotope production for Nycomed, Amersham and Cygne Production of short - lived positron emitters for University Research in catalysis using PEP Beam analysis techniques for material research (University related) This AVF Cyclotron will be shut - down in 2002 - 03 and a new Negative ion , IBA, Cyclone 30, 18-30 MeV is planned.

304

299


[1] INSTITUTE: Groningen University Hospital PET Centre P.O. Box 30.001 NL-9700 RB Groningen


+31 50 361 3311 +31 50 361 1687


Professor William Vaalburg


A.M.J. Paans P.H. Elsinga

[3] TYPE OF

CYCLOTRON: AVF YEAR OF:


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 780 750 Typical beam employed (µA) 20 - 30 20 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





305

300


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 > 94 1 300 Yes No

20Ne (d, α) 18F 7 16O (α,d )18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG > 8 200/year Yes No Yes No DOPA 0.5 60/year Yes No Yes No MPPF 0.5 10/year Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline > 3 60/year Yes No Yes No Tyrosine 2-3 40/year Yes No Yes No Raclopride 0.5 30/year Yes No Yes No Verapamil Bicarbonate Acetate CSP - 12388

2 > 3 > 3 1

20/year 20/year 10/year 20/year

Yes No Yes No Yes No Yes No

Yes No Yes No Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 0.8 - 1.0 500/year 16O (p, n) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 2-4 600/year OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


306

301


[1] INSTITUTE: Mallinckrodt Medical P.O. Box 3 NL-1755 ZG Pette


+31 224 567 890 [email protected] +31 224 563 566


Eng. (Ir.) H. Buurlage General Manager


Eng. (Ir.) F. de Lange, Head of Cyclotron Operations

[3] TYPE OF



MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 2×180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

130 130 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?



Yes No





307

302


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

308

303


[1] INSTITUTE: Mallinckrodt Medical P.O. Box 3 NL-1755 ZG Petten


+31 224 567 890 [email protected] +31 224 563 566


Eng. (Ir.) H. Buurlage General Manager


Eng. (Ir.) F. de Lange, Head of Cyclotron Operations

[3] TYPE OF

CYCLOTRON: AVF – Positive ion YEAR OF:


MANUFACTURER: Philips (II) UPGRADE: 1996 MODEL: AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-30 Yes N Maximum beam available (µA) 150 Typical beam employed (µA) 120 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

100 100 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0











Yes No


Yes No





309

304


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2

(l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price

/GBq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

310

305

2005 COUINRTY NETHERLANDS NET-7 [1] INSTITUTE: Vrije Universiteit, BV Cyclotron VU

De Boelelaan 1081 NL-1081 HV Amsterdam


+31-20-4449123 [email protected] +31-20-4449128


Dr. P.J. van der Jagt General Director


Drs. P. Kruijer/Chemist Dr. ing. F. van Langevelde/Physicist P.J. van Leuffen/Daily Operations R. Mooij/Chief Cyclotron Operator

[3] TYPE OF


H- IBA S.A. Cyclone 18/9


1997


Beam energies (MeV) 18 9 Yes x Maximum beam available (µA) 80 Typical beam employed (µA) 70 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT, O-15, Zr-89, I-124 [9] Do you supply radionuclides to other institutions?



Yes x No


511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 2 Positron emission tomography (PET) 2 – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for


[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No x [14] Is the cyclotron used for targetry development? Yes x No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes x No [16] Does your institute accept IAEA research fellows for training/experience? Yes x No

311

306


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 95 Yes x

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15 Yes x No Yes x No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Yes x No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


312

307

2005 COUNTRY NETHERLANDS NET- 8 [1] INSTITUTE: Vrije Universiteit

BV Cyclotron VU De Boelelaan 1081 NL-1081 HV Amsterdam


+31-20-4449123 [email protected] +31-20-4449128





[3] TYPE OF


H+ Philips AVF


1965


Beam energies (MeV) 6-28 3-16 10-45 6-32 Yes No x Maximum beam available (µA) 200 Typical beam employed (µA) 35 15 10 10 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications













Yes x No





313

308


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15 Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No x Yes x No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Rb-81 is produced for the production of Rb/Kr-generators

314

309

2005 COUNTRY NETHERLANDS NET- 9 [1] INSTITUTE: Kernfysisch Versneller Institute

Zernikelaan 25 NL-9747 AA Groningen


+31 50 363 3600 [email protected] +31 50 363 4003


W K van Asselt


[3] TYPE OF



1996

[4] CYCLOTRON CHARACTERISTICS: Compact superconducting cyclotron for research in physics, also used for radiotherapy related radiobiological

experiments, development of dose imaging systems and radiation hardness testing Ions of alle elements up to lead are accelerated, for more information see http://www.kvi.nl/ 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 200 Yes No x Maximum beam available (µA) 100 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours/ year Hours/year

for radionuclide

production

Hours/year for research Hours/year for

maintenance

Hours/year for

applications

[6] CYCLOTRON APPLICATIONS: Hours/year Hours/year Radiobiology: Radiography:



Activation analysis: Detector development









Yes No




Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes X No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No X [16] Does your institute accept IAEA research fellows for training/experience? Yes X No

315

310


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


316

311

2005 COUNTRY NETHERLANDS NET-10 [1] INSTITUTE: Vrije Universiteit, BV Cyclotron VU

De Boelelaan 1081 NL-1081 HV Amsterdam


+31-20-4449123 [email protected] +31-20-4449128





[3] TYPE OF


H- IBA S.A. Cyclone 18/9


2004


Beam energies (MeV) 18 9 Yes x No Maximum beam available (µA) 80 Typical beam employed (µA) 70 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT, O-15, Zr-89, I-124 [9] Do you supply radionuclides to other institutions?



Yes x No





317

312


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 95 Yes x

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15 Yes x No Yes x No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


318

313

25. NORWAY

COUNTRY: NORWAY NOR-1

[1] INSTITUTE: University of Oslo Department of Physics P.O. Box 1048, Blindern N-0316 Oslo


+47 22 856 460 +47 22 856 422


Professor Magne Guttormsen


John Rekstad Svein Messelt

[3] TYPE OF

CYCLOTRON: Sector focusing YEAR OF: (I)

INSTALLATION 1979

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 35 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 35 17 47 35 Yes No Maximum beam available (µA) 100 80 10 20 Typical beam employed (µA) 70 50 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





319

314


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


320

315

26. PHILIPPINES

2005 COUNTRY: PHILIPPINES PHI-1

[1] INSTITUTE: Positron Emission Tomography and Cyclotron Facility St. Luke’s Medical Center, E. Rodriguez Avenue Quezon City 1102


+63 2 7268369 [email protected] /[email protected] +63 2 7268369


Jonas Y. Santiago, MD, FACNP Chief, Section of PET


Nathaniel B. de Vera, Manager, PET & Cyclotron Facility Katheryn S. Mandap, Radiochemist

[3] TYPE OF

CYCLOTRON: Negative Ion YEAR OF:

(I) INSTALLATION 2001 (November)

MANUFACTURER: GE (II) UPGRADE: MODEL: Minitrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.5 Yes No x Maximum beam available (µA) 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

5 4 0 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: N/A Radiography: N/A

Materials science: N/A Proton therapy: N/A

Physics: N/A Neutron therapy: N/A

Activation analysis: N/A Other (specify) N/A






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): F-18 and N-13 [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No x


Yes x No x




[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No x [14] Is the cyclotron used for targetry development? Yes No x [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No x [16] Does your institute accept IAEA research fellows for training/experience? Yes x No

321

316


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 18.9 for 60 min bombardment 16 for 60 min

97 95

1.4 1.4

Yes No x


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5.5 for 30min 1 per day Yes x No Yes No x 9.4 for 60 min

bombardment Yes x No Yes No x


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

N/A Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

N-13 ammonia

1.1 for 30 min bombardment

occasional 16O(p,a)13N Yes No x


(list)


used

Price/

GBq

N/A OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu N/A Yes No Yes No 67Ga N/A Yes No Yes No 86Y N/A Yes No Yes No 94mTc N/A Yes No Yes No 103Pd N/A Yes No Yes No 111In N/A Yes No Yes No 123I N/A Yes No Yes No 124I N/A Yes No Yes No 201Tl N/A Yes No Yes No 211At N/A Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) This is the first cyclotron in the country; will be dedicated to produce 18F FDG and

13N Ammonia for use in PET

procedures of the Medical Center and supply to other users on request. Detailed information will be supplied when the unit becomes operational.

322

317

27. POLAND

2005 COUNTRY: POLAND POL-1

[1] INSTITUTE: Henryk Niewodnicanczanski Institute of Physics (HNIP), Radzikowskiego 152 PL-31-341 Krakow


+48 12 637 0222 [email protected] +48 12 637 5441


Mr. Edmund Makewicz, MSc., EE Head of Cyclotron Unit


Mr. Henryk Doruch, MSc., EE/Mr. Marek Talach, MSc., EE Dr. Ryszard Taraszkiewicz, Cyclotron Research Dr. Barbara Petelenz, head – Laboratory of Physical Chemistry

[3] TYPE OF

CYCLOTRON: AVF isochronous YEAR OF: (I)

INSTALLATION 1997

MANUFACTURER: HNIP (II) UPGRADE: 2001 MODEL: AIC-144 [4] CYCLOTRON CHARACTERISTICS: K-factor = 60; extraction radius R = 0.62 M. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-60 15-30 30-60 Yes No Maximum beam available (µA) 100/45

MeV 100 30

Typical beam employed (µA) 2-5 n/a 3-5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

Variable [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: planned Radiography:

Materials science: Proton therapy: planned

Physics: variable Neutron therapy: planned




Mössbauer sources? (specify which & quantity) Yes No variable


Intense neutron beam? (specify average En = ?) Yes No planned

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 111In, 211At [9] Do you supply radionuclides to other institutions?



Yes No





323

318


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No F-Dopa Yes No Yes No ML01 Yes No Yes No ML03 Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline Yes No Yes No Deprenyl Yes No Yes No Methionine Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In variable Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At variable Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 57Co — occasionally, used on site in test of Si strip detectors, 99Rh — occasionally, used on site for Mössbauer research, 173Hf — occasionally, used on site in model studies of chemistry of transuranium elements, 178W, 181W — occasionally, used on site in model studies of chemistry of transuranium elements.

324

319

2005 COUNTRY: POLAND POL-2

[1] INSTITUTE: Warsaw University Heavy Ion Laboratory uL Pasteura 5A PL-02-097 Warszawa


+48 22 658 2021 +48 22 659 2714


Professor Dr. hab. Jan Kowracki


Mr. Tomasz Czosnyka Mr. Jerzy Jastrzebski

[3] TYPE OF

CYCLOTRON: AVF, 4-sector, 2-dee, 2 m diameter

YEAR OF: (I)

INSTALLATION 1994

MANUFACTURER: Magnet - Dubna, rest all Polish parts

(II) UPGRADE: ECR installation, 1997

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) * Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Planned after the ECR installation Yes No


Yes No





325

320


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


Basic research, e.g. Coulomb excitation, Giant Dipole Resonances In-beam high-spin spectroscopy Radioactive decays in He-jet system and isotope separation in-line.

326

321

28. ROMANIA

2005 COUNTRY: ROMANIA ROM-1

[1] INSTITUTE: National Institute for Physics and Nuclear Engineering IFIN-HH Bucharest, Str. Atomistilor 407 POB MG-6, 76900 Bucharest-Magurele

TELEPHONE NO./ FAX NO.: E-MAIL ADDRESS:

+40 1 404 23 00/4406/+401 4023 1701 [email protected]


Dipl. Eng. Dorin Dudu Head of the Cyclotron Accelerator


Dip. Eng. Nicolae Tetcu, Deputy Head Dr. Eugen Ivanov Dr. Petru Mihai Racolta

[3] TYPE OF

CYCLOTRON: Classical, var. energy, 60 cm magnetic pole radius


1957/1958

MANUFACTURER: URSS - Petrograd/Leningrad

(II) UPGRADE: 1970 development of 7 beam transport lines 1999 upgrading of RF controls

MODEL: U-120/1956 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-15 10-13 - 20-27 Yes No Maximum beam available (µA) 25 25 - 10 Typical beam employed (µA) 55 10 - 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

45 10 10 10 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: - Radiography: -

Materials science: 15 Proton therapy: -

Physics: 5 Neutron therapy: -

Activation analysis: 5 Other (specify) -


Calibration sources? (specify which & quantity) 22

Na/1 mCi Yes No



Intense neutron beam? (specify average En = ?) 5 MeV Ø –

1012

n/cm2s typically for d (13 MeV) on Be target.

Yes No

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18f, 103Pd, 22Na, 67Ga, 111In, 123I, 68Ge [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



327

322


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


328

323

29. RUSSIAN FEDERATION

2005 COUNTRY: RUSSIA RUS-1

[1] INSTITUTE: Bakoulev Scientific Centre for Cardiovascular Surgery Roubevsekoe sh 135 121552 Moscow


+7 095 414 7917 [email protected] +7 095 414 7782


Dr. Evgeny Derevyanko, PhD. Head of PET Radiochemistry


Professor Leo Bokeria, Director of Bakoulev Cardiosurgery Dr. Iracly Aslanidis, Head of Nuclear Diagnostics Dr. Vladimir Leonov, Cyclotron Engineer

[3] TYPE OF

CYCLOTRON: Self-shielded, proton cyclotron

YEAR OF: (I)

INSTALLATION 1998 - mounter

MANUFACTURER: CTI, Inc. (II) UPGRADE: 2001 - accepted MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Nil nil Nil Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 11C - acetate, 11C - methinione, 15O – water [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence - Gamma camera - Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal - – Plant biochemistry - [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



329

324


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 10 70-95 1.1 - 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N - ammonia 1 1/month 16O(p,a) Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


330

325


[1] INSTITUTE: Central Research Institute of Roentgenology and Radiology 189646 St. Petersburg Pesochny-2 Leningrad ul., 70


+7 812 596 6609 [email protected] or [email protected] +7 812 596 6609


Oleg A. Shtukovski, PhD. Head of the Department of Cyclotron Radiopharmaceuticals


Mikhail Korsakov, Scientific Expert

[3] TYPE OF

CYCLOTRON: Isochronous cyclotron with variable energy

YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: Efremov Institute, St. Petersburg, Russia

(II) UPGRADE:

MODEL: MGC-20P [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-18 7-10 10-28 4-20 Yes No Maximum beam available (µA) 100 50 30 25 Typical beam employed (µA) 30 - - - [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

60 40 12 8 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 11 different clinical institutions in St. Petersburg, 2times/week

Yes No


Yes No





331

326


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15-18 95+ 1,4 nil 150 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5-10 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C – butyrate 4-6 2/week Yes No Yes No 11C – acetate 2-3 validation for

patient studies Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N – ammonia 3-5 1 runday/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 2/week Yes No Yes No 124I 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 123I - iodide, 123I – iodo hippurate, 123I – iodo bengal rose, 123I – iodo iodopentadecanoic acid.

332

327


[1] INSTITUTE: Cyclotron Co. Ltd. Bondarenko Sq. 1, Obninsk, Kaluga Region 249033


+7 95 255 2385 [email protected] +7 95 255 2326


Professor N.N. Krasnov Director General


A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General

[3] TYPE OF

CYCLOTRON: lsochronic YEAR OF: (I)

INSTALLATION 1999

MANUFACTURER: Scientific Institute, Electrophysics

(II) UPGRADE: 2003

MODEL: RIC - 14 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 14 Yes No Maximum beam available (µA) 1000 Typical beam employed (µA) 850 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

52 weeks 130 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:




57

Co, 109

Cd , 68

Ge


Calibration sources? (specify which & quantity) Yes No 68Ge


Co


Co,109

Cd





Yes No





333

328


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


20Ne (d, α)18F 16O (α,d)18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Upto 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Upto 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

334

329


[1] INSTITUTE: Cyclotron Co. Ltd. Bondarenko Sq. 1, Obninsk, Kaluga Region 249033


+7 95 255 2385 [email protected] +7 95 255 2326


Professor N.N. Krasnov Director General


A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General

[3] TYPE OF

CYCLOTRON: Classical cyclotron YEAR OF: (I)

INSTALLATION - 1963

MANUFACTURER: Scientific Institute Electrophysics

(II) UPGRADE: 1993

MODEL: U - 150 - 1 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 22 Yes No Maximum beam available (µA) 1000 1000 Typical beam employed (µA) 700 700 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

52 weeks in year 2000 144 hours 4 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:




Co, 109

Cd, 68

Ge


Calibration sources? (specify which & quantity) Yes No 68Ge


Co


Co,109

Cd



institutions?


Yes No


Yes No





335

330


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


20Ne (d, α)18F 16O (α,d)18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Up to 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Up to 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

336

331


[1] INSTITUTE: Institute of Human Brain RAS 9 Pavlov Street St. Petersburg 197376


+7 812 234 9347 [email protected] +7 812 234 3247


Demianov Alexandr Cyclotron Engineer


Krasikova Raisa, Head of Radiopharmacy

[3] TYPE OF

CYCLOTRON: Medical YEAR OF: (I)

INSTALLATION 1990

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 15-40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

16 7 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify): PET 16









Yes No





[14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

337

332


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 14.8 95 1.0 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

L-11C – methyl methionine

4.4 4/week Yes No Yes No

Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N[NH3] 2.6 1/month 15O(p,a)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq 15O[H2O] 4.4 25/week 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


338

333


[1] INSTITUTE: Kurchatov Institute of Atomic Energy (KIAE) Moscow 123 182


+7 095 196 9782 or +7 095 196 9977* +7 095 737 0600


Unezhev Vitaly


Oglobin Alexei V.E. Jarosh

[3] TYPE OF

CYCLOTRON: KIAEC YEAR OF: (I)

INSTALLATION 1976

MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 30 70 60 Yes No Maximum beam available (µA) 30 15 15 20 Typical beam employed (µA) 25 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications









Intense neutron beam? (specify average En = ?) Yes No En=30MeV




Yes No





339

334


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 98.6 1.5 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No On

request Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 37 3 days/week Yes No Yes No On

request 124I Yes No Yes No 201Tl 10 2 days/month Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

340

335

COUNTRY: RUSSIA RUS-7

[1] INSTITUTE: Nuclear Physics Institute at Tomsk Polytechnic University Lenina 2-1 St., P.O. Box 25 634050 Tomsk


+7 3822 417 953 or +7 3822 424 003* [email protected] +7 3822 423 934


V.M. Golovkov Deputy Director


A.I. Komov*, Chief of the Cyclotron Department

[3] TYPE OF

CYCLOTRON: Tomsk(U-120) YEAR OF: (I)

INSTALLATION 1959

MANUFACTURER: “Electrosila” St. Petersburg

(II) UPGRADE: 1971

MODEL: R - 7M [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 14 30 28 Yes No Maximum beam available (µA) 35 50 20 55 Typical beam employed (µA) 30 45 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications









Intense neutron beam? (specify average En = ?) Yes No En=7.5 MeV

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123 I, Sodium Iodide, Iod - O - gippurate, MIBG, Iodophen [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Institute of Cardiology of Tomsk Research Centre (TRC) of Siberian Branch of Russian Academy Medical Sciences (SB RAMS)- 2 per week; Institute of Oncology of TRC SB RAMS- 2 per week; Siberian State Medical University- 2 per week.

Yes No


Yes No


511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



341

336


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Since 1990, TI-199 isotope is produced as analog of TI-201. The “Thallium Chloride, TI-99” radiopharmaceutical is provided to some medical institutes. Deliverables are realized twice per week. Quantity of the supplying radiopharmaceutical with the TI-11 is equal to 5-6 Ku/year.

342

337


[1] INSTITUTE: Research Institute of Nuclear Physics St. Petersburg Technical University 194223 St. Petersburg, ul. Kurchatova 10


+812 552 98 96 [email protected] +812 552 98 31


V.N. Lomasov Director, Research Institute of Nuclear Physics (RINP)


B.V. Zabrodin, Director of the Cyclotron Laboratory, RINP

[3] TYPE OF

CYCLOTRON: MGC-20 YEAR OF: (I)

INSTALLATION 1985

MANUFACTURER: SRIEPhA, Russia (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 27 20 Yes No Maximum beam available (µA) 50 50 20 25 Typical beam employed (µA) 20 20 5 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

0 – 50 0 - 50 0 – 20 2 – 5 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:

Materials science: 0 - 20 Proton therapy:

Physics: 0 - 20 Neutron therapy:

Activation analysis: sometimes Other (specify)






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 124I, 85Sr. [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? As required. Yes No


Yes No





343

338


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 1 - 10 As required Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 1 - 10 as required Yes No Yes No 124I 0,5 - 4 as required Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 85Sr

344

339


[1] INSTITUTE: V.G. Khlopin Radium Institute 2nd Murinski Prospect 28 149 021 St. Petersburg


+7 812 247 [email protected] +7 812 237 6181


L.M. Solin, PhD. Head of Laboratory


[3] TYPE OF


INSTALLATION 1988

MANUFACTURER: Efremov NIIEFA (II) UPGRADE: MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-18 3-10 8-24 8-20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 5-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Sodium iodide, 123I; Sodium-Iodohippurate, 123I; 123I -MIBG; 123I -BMIPP; 67Ga Citrate: [9] Do you supply radionuclides to other institutions?



Yes No





345

340


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 3.5 1/ month Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 10 2-3 / week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

346

341

30. SAUDI ARABIA

2005 COUNTRY: SAUDI ARABIA SAU-1

[1] INSTITUTE: King Faisal Specialist Hospital and Research Centre P.O. Box 3354, Riyadh 11211


+966 1 442 7856 [email protected] +966 1 442 4743


Eng. Salman Melibari Head of, Cyclotron Operations


Eng. Salam Rahma, Senior Engineer Ahmad Algaith, Engineer Faisal Alromayanman, Engineer

[3] TYPE OF

CYCLOTRON: Positive ion, AVF, electrostatic extraction

YEAR OF: (I)

INSTALLATION 1981


(II) UPGRADE:

MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28.5 15 38 30 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 100 100 100 80 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

45 < 10 < 10 < 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:


Physics: Neutron therapy: 25 (on hold)






Intense neutron beam? (specify average En = ?) Yes No En =14 MeV

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 103Pd, and 123I [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No 124I, 203Pb


Yes No





347

342


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 28 > 95 0.33 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15 Every day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 3.7 1-2/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 44.0 Every week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 16.7 Occasionally Yes No Yes No 123I 28.0 Every day Yes No Yes No 124I 16.0 Occasionally Yes No Yes No 201Tl 34.0 Every Week Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Kr81m generator production everyday.

348

343

31. SLOVAKIA

2005 COUNTRY: SLOVAKIA SLR-1

[1] INSTITUTE: Slovak Office for Standards, Metrology and Testing Cyclotron Centre of the Slovak Republic Stefanovicova 4, P.O. Box 76, SK-81005 Bratislava


+421 7 524 91085 [email protected] +421 7 524 91050


Dr. Dusan Podhorsky Chairman


Dr. Peter Kovac, Senior Operators Dr. Josef Kristiak, Senior Scientist Professor Fedor Macasek, Senior Scientist Professor Jan Ruzicka, Scientific Secretary Professor Stefan Saro, Senior Scientist

[3] TYPE OF

CYCLOTRON: Fixed energy H- and D- ions

YEAR OF: (I)

INSTALLATION 2001 - 2002

MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications



Physics: 5 (Planned) Neutron therapy:







[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, 11C – Raclopride [9] Do you supply radionuclides to other institutions?



Yes No





349

344


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 2 x 50 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 2 x 20 Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 40 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 16O(p,α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

CO2 (10) 14N(p,n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


350

345

32. SOUTH AFRICA

2005 COUNTRY: SOUTH AFRICA SAF-1

[1] INSTITUTE: Themba LABS P.O. Box 722, Somerset West 7129


+27 21 843 1334 [email protected] or [email protected]* +27 21 843 3525


Professor J.F. Sharpey-Schafer until 30 June 2005 Professor K Bharuth-Ram from 1 July 05 to 31 December 06 Dr ZZ Vilakazi, from 1 January 2007 Director


Mr Y Manjoo, Head - Administration Dr C. Naidoo*, Head - Radionuclide Production Dr. L. Conradie, Head - Accelerator Group

[3] TYPE OF

CYCLOTRON: Separated sector w/ solid pole injector cyclotron

YEAR OF: (I)

INSTALLATION 1986

MANUFACTURER: NAC (II) UPGRADE: 1994 (2nd injector) MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 66 - 200 Yes No Maximum beam available (µA) 180 Typical beam employed (µA) 90 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

144 38 24 24 ~20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:




Radionuclide production

38






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F and 18F FDG; 68Ge; 82Sr, 88Yr [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Nuclear medicine centres in South Africa and Namibia — on a weekly basis. 22Na to USA , European and Far East Markets, RbCl & Ga irradiated targets to USA (DOE)

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical, Small animal, Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



351

346


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 2 2-4 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG To be

determined, not in production yet

4 times a week Yes No Yes No Not availabl

Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga weekly Yes No Yes No $ 372 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I weekly Yes No Yes No $ 405 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/81MKr generators, 123I – MIBG, 123I-NaI capsule, , 123I-NaI solution, 67Ga-resin

352

347

33. SPAIN

2005 COUNTRY: SPAIN SPA-1

[1] INSTITUTE: BARNATRON Anselm Clave, 100 08950 Espluges de Llobregar Barcelona


+34 93 473 5144 [email protected] +34 93 473 4839


Isabel R. de Arellano Radiochemist, responsible for Installation


Carlos Piera, responsible for Quality Control Pedro Larroza, Technician – Production Martin Vargas, Technician – Quality Control

[3] TYPE OF


INSTALLATION 2001

MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.4 MeV Yes No Maximum beam available (µA) Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

11 7 - 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 Advanced GE – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



353

348


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F >95.5 1.6 mL Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 65/2 MR bomb 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


354

349


[1] INSTITUTE: Centro Andaluz de Díagnóstíco PET (CADPET) Ronda de Capuchinos, 11 41009 Sevilla


+34 954 432 537 ext. 172 administrací[email protected]/[email protected]/[email protected] +34 954 435 5850


Mr. Miguel Perez Consejero Delegado (Managing Director)


Mr. Miguel Cantero, Radiochemist Mrs. Rocío Iglesias, Radiopharmacist

[3] TYPE OF


INSTALLATION 2001

MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace 2132402 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) 75 Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

26 26 n/a [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:




Radiopharmaceuticals

26/week







If yes and available, name of institution/s & how often? CADPET Málaga: 3/week; Hospital Universitario Virgen del Rocío (Sevilla): 5/week Hospital Universitario Virgen de las Nieves (Granada): 6/week; IPO (Lisboa): 5/week ;

Yes No


Yes No





355

350


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 95 1,5 mL Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


356

351


[1] INSTITUTE: Centro PET Complutense (CPC) Manuel Bartolome Cossio, 10 E-28040 Madrid


+34 91 534 4896 [email protected] +34 91 553 0845


José Miguel Alfonso President


Antonio Maldonado, Medical Director Magdalena Melgarejo Icaza, Laboratory Director José Manuel Nieto, Administrative Director

[3] TYPE OF

CYCLOTRON: Superconducting, negative ion

YEAR OF: (I)

INSTALLATION 1994

MANUFACTURER: Oxford Intr. (II) UPGRADE: MODEL: OSCAR IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify):

FDG fabrication







If yes and available, name of institution/s & how often? IVO (Valencia): 3-4/week; Hospital del Rocío (Sevilla: 5-9/week; Hospital Dr. Peset (Valencia): 2-3/week

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical 1 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






357

352


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 25 >95 5 ± 400 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 25 2-4/day Yes No Yes No P45,000

/injection to patient

Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


Centro PET Complutense S.A. is dedicated only in the production and utilization of 1`8FDG for clinical use. During this utilization it participates in diverse projects of clinical investigation.

358

353


[1] INSTITUTE: Clinica Universitaria de Navarra Facultad de Medicina Apartado, 4029 31080 Pamplona


+34 948 255 400 ext. 4941 [email protected] +34 948 296 500


José A. Richter MD, PhD. Chief of Nuclear Medicine


Josep M. Marti-Climent, PhD. Iván Peñuelas, PhD. Javier Arbizu, MD María J. García-Velloso, MD, PhD.

[3] TYPE OF

CYCLOTRON: Double particle YEAR OF: (I)

INSTALLATION 1996


production

h/week for

research

h/week for

maintenance

h/week for

applications

10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





359

354


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)


20Ne (d,a) 18F 16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


360

355


[1] INSTITUTE: MOLYPHARMA Avenida Dr. Severo Ochoa, 37-41-1 28100 Alcobendas Madrid


+34 91 490 5730 [www.molypharma.es] +34 91 490 5740


Mr. Rafael Jimenez Shaw Director de Operaciones


Mr. Tomas Arroyo, Radiopharmacist

[3] TYPE OF

CYCLOTRON: GE Minit-11 YEAR OF: (I)

INSTALLATION 2001

MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: (ESTIMATION) Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 5 during 2001 (expected) Yes No


Yes No





361

356


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 52 96 0.5 Yes No

20Ne (d,α)18F 16O (α, d)18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 37 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 5 Daily 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


362

357

34. SWEDEN

2005 COUNTRY: SWEDEN SWE-1 [1] INSTITUTE: Uppsala Universitet

PET-Centrum UAS, S-75185 Uppsala


+46 18 471 5388 [email protected] +46 18 471 53890


Joachim Schultz Engineer


Mr. Gunnar Antonio, Senior Chemist

[3] TYPE OF

CYCLOTRON: Isochron, deflector YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 17 MeV protons, 8,5 deuterons, mx 50 µA on target 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 17 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 45 45 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



363

358


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 95 0.9 1.2 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

CO2 ~20 5/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15O water 1 5/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


364

359

35. SWITZERLAND

2005 COUNTRY: SWITZERLAND SWI-1

[1] INSTITUTE: Paul Scherrer Institute CH-5232 Villigen-PSI


+41 56 310 2813 [email protected] +41 56 310 2849


Professor P.A. Schubiger Head of Centre for Radiopharmacy


Simon Ametamey Peter Bläuenstein Roger Schibli

[3] TYPE OF

CYCLOTRON: PSI construction YEAR OF: (I)

INSTALLATION 1974

MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Total beam is 200 Micro Amp; a splitter divides into main beam and a small part

for the radiopharmacy; this sheet is filled out with respect to RPH applications 1H 2H 3He 4He Dual Beams Beam energies (MeV) 72 - - - Yes No Maximum beam available (µA) 70 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



[14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No


365

360


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 50 >80 2 50 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Flumazenil Yes No Yes No Raclopride Yes No Yes No Methionine Yes No Yes No Ketamine Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 2/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are concentrating on research of new radiopharmaceuticals for brain imaging and tumour therapy. The products are investigated in vitro and in vivo (animals). If good results are obtained, first clinical tests are started, but there is no regular distribution to hospitals anywhere. In addition to 18F, we are producing 11C, 67Cu and 76Br.

366

361


[1] INSTITUTE: Geneva University Hospitals (HUG) Department of Radiology and Medical Informatics, Nuclear Medicine Service, Cyclotron Unit 24, rue Micheli-du-Crest, CH-1211 Geneva


+41 22 37 27 580 [email protected] +41 22 37 27 585


Dr. Dmitri Soloviev, PhD. Radiopharmacist, Qualified Person, Head of Cyclotron Unit a.i.


Claire Tamburella, PhD., Cyclotron Physicist

[3] TYPE OF

CYCLOTRON: Negative ion, fixed energy


2001 (machine manufactured in 1997)

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 40 15 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 18F, 64Cu, 55Co, 86Y, 124I [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? [18F]FDG to PET Centers in

Switzerland daily beginning in December, 2005.

Yes No


Yes No





367

362


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 95 1.5; 2.5;3 600 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

[18F]FDG 20 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

[11C]acetate 20 3 d/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


368

363


[1] INSTITUTE: University Hospital Zürich, PET Center Raemistrasse 100 CH-8081 Zürich


+41 1 255 1111 [email protected] +41 1 255 4428


Professor A. Schubiger


Dr. G. Westera

[3] TYPE OF

CYCLOTRON: Fixed energy, negative ion


1994

MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 Stand-by 20 Beam on target 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – DOPA, FLT, 11C – Various [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) –Clinical 2 –Small animal 1 –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



369

364


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 110 95 1.6 600 Yes No

Ne (d, α) 18F 600 MBq 16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 45 1/day Yes No Yes No SFR

200 18FET 2.5 1/week Yes No Yes No 18F- 1.5 1/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 2.5 1/2 weeks Yes No Yes No Flumarenil 2.5 1/2 weeks Yes No Yes No Acetate 2.5 1/month Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13NH3 10 10 / week 16O (p, a) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H2O Continuous 10 / week 15N(p.n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


370

365

36. SYRIAN ARAB REPUBLIC

2005 COUNTRY: SYRIA SYR-1

[1] INSTITUTE: Atomic Energy Commission of Syria (AECS) P.O. Box 6091 Damascus


+963 11 391 2896 or 391 3923 +963 11 611 2289


Dr. Abdul Hamid Al-Reyyes


[3] TYPE OF

CYCLOTRON: Negative ion, variable energy

YEAR OF: (I)

INSTALLATION 2001

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No

Maximum beam available (µA) 350 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In, 103Pd, 11C, 15O [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Not yet. Yes No


Yes No





371

366


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F ~ 90 97 1.3 250 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


372

367

37. TURKEY

2005 COUNTRY TURKEY TUR-1 [1] INSTITUTE: MONROL Nuclear Products Inc.

Tubitak MAM Teknoparki Gebze / Kocaeli TELEPHONE NO.:


+90 262 646 40 66 [email protected] +90 262 646 40 66


Baris Cakir Eng. / Specialist


Ozgur Ustaoglu / Asst. Specialist H. Ozgur Kazanci / Asst. Specialist

[3] TYPE OF


(-) Ion Beam CTI RDS 111


2000


Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

31 30 - 1 - [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT, FDOPA [9] Do you supply radionuclides to other institutions?


Various National Institutions [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No





373

368


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l) Yes No

18O (p, n) 18F 55.5 97 1.2 600

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 25 2 Yes No Yes No - Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


374

369

2005 COUNTRY TURKEY TUR-2 [1] INSTITUTE: MONROL Nuclear Products Inc.

Tubitak MAM Teknoparki Gebze / Kocaeli TELEPHONE NO.:


+90 262 646 40 66 [email protected] +90 262 646 40 66


Baris Cakir Eng. / Specialist


Ozgur Ustaoglu / Asst. Specialist H. Ozgur Kazanci / Asst. Specialist Halil Kusanlı / Asst. Specialist

[3] TYPE OF


(-) Ion Beam IBA 18/9


2004 -



for radionuclide

production


maintenance

Hours/week for

applications

31 30 - 1 - [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT FDOPA [9] Do you supply radionuclides to other institutions?


Various National Institutions [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No





375

370


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l) Yes No

18O (p, n) 18F 166.5 97 2.1 2000

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 74 2 Yes No Yes No - Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


376

371

38. UNITED KINGDOM

2005 COUNTRY: UNITED KINGDOM UK-1

[1] INSTITUTE: Douglas Cyclotron Unit Clatterbridge for Oncology Bebington, Wirral L63 4JY


+44 151 334 6366 [email protected] +44 151 334 2845


Dr. Andrzej Kacperek Head, Cyclotron Unit


B. Marsland

[3] TYPE OF

CYCLOTRON: AVF, single particle, fixed energy

YEAR OF: (I)

INSTALLATION 1984

MANUFACTURER: Scandinotrix (II) UPGRADE: 1988 (beamline of proton therapy)

MODEL: MC-62 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 62 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 - 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications







Na




[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu, 55Co [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Paterson Institute, Christie Hospital, (4-8/month) Manchester, M20 4BX, U.K.

Yes No


Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



377

372


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 95 1 Mostly recycled

Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1 1/month Yes No Yes No Research

contract 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We only produce isotopes, not pharmaceuticals.

378

373


[1] INSTITUTE: Hammersmith Imanet Limited Cyclotron Building Hammersmith Hospital Ducane Road, London W12 ONN


+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029


Sue Matthews Managing Director


Bruce Mackay, Cyclotron Operations Manager Mike Renton, Chief Cyclotron Engineer Shaun Creasey, Radiochemistry Production Manager

[3] TYPE OF

CYCLOTRON: O-15 generator YEAR OF: (I)

INSTALLATION 1991

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 3D [4] CYCLOTRON CHARACTERISTICS: Positive ion, fixed energy, fixed frequency, internal beam only. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3.8 Yes N Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) O-15









Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






379

374


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15H2O continuous daily 14N(d,n)15O 15CO continuous daily 14N(d,n)15O 15O continuous weekly 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


380

375




+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029





[3] TYPE OF

CYCLOTRON: Positive ion, variable energy

YEAR OF: (I)

INSTALLATION 1986

MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 40 Mark II [4] CYCLOTRON CHARACTERISTICS: Isochronous cyclotron for acceleration of light ions, delivers high quality

external beams via a beam transport system with seven (7) lines to more than 20 installed targets. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-40 5-20 12-53 10-40 Yes No Maximum beam available (µA) 65 65 50 60 Typical beam employed (µA) 30 30 30 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? Daily Yes No


Yes No





381

376


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 10/F2; 55/F- 95 1.2 150 400 10 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 daily Yes No Yes No Wide range of compounds

Yes No Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Extensive range of compounds

daily Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15CO continuous daily 14N(d,n)15O 15CO2 continuous daily 14N(d,n)15O 15H2O continuous daily 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.3 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/Kr generators

382

377




+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029





[3] TYPE OF

CYCLOTRON: GE PETtrace YEAR OF: (I)


MANUFACTURER: GEMS Uppsala. (II) UPGRADE: MODEL: PETtrace self-

shielded

[4] CYCLOTRON CHARACTERISTICS: Positive ion, fixed energy, fixed frequency, internal beam only. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify) O-15









Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for






383

378


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F as F-

100 95 0.8 Yes No

18Ogas (p, n) 18F as F2

50


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

11C CO2 Yes No Yes No 11C Methane Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15H2O continuous daily 14N(d,n)15O 15CO continuous daily 14N(d,n)15O 15O continuous weekly 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


384

379


[1] INSTITUTE: John Mallard Scottish PET Centre University of Aberdeen Department of Biomedical Physics and Bioengineering Foresterhill, Aberdeen, AB9 2ZD


+44 1 224554767 [email protected] +44 1 224552514


Dr. Andrew Welch Director


M.G. Dodd, Cyclotron Engineer Dr. Lutz Schweiger, Senior Chemist

[3] TYPE OF


INSTALLATION 1998

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No

Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 12 4 0.2 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 16 Radiography:



Activation analysis: Other (specify): Target dev. 1









Yes No


511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



385

380


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 16 40 1.1 180 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 8 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline 2 weekly Yes No Yes No Methylene blue 4 weekly Yes No Yes No methionone 4 Yes x No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 3 as required 16O(p, Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 3 weekly 15N(p,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


386

381


[1] INSTITUTE: St. Thomas Hospital The Clinical PET Centre Guy’s, King’s, St. Thomas School of Medicine Lambeth Palace Road, London SE1 7EH


+44 207 188 4988 +44 207 922 0790


Dr Michael O’Doherty Director, The Clinical PET Centre


Ms. Margaret Dakin Mr. Gavin d’Costa Mr. Phil Halstead Mr. Paul Marsden

[3] TYPE OF


INSTALLATION 1991

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

19 15 4 As required [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu – In development; 18F – FLT – In development; 18F –Peptides – In development [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Fluoride for scanner applications Yes No


Yes No





387

382


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F > 95 0.5 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 2 /day Yes No Yes No £ 325/

patient dose

FLT Yes No Yes No FMISO Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C Metnionine Yes No Yes No 11C Fumazenl Yes No Yes No 11C Methyl acetate

Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13NH3 16O(p,)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 15N(p,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


388

383


[1] INSTITUTE: University of Cambridge Wolfson Brain Imaging Centre Box 65, Addenbrook's Hospital Cambridge CB2 2QQ


+44 1223 33 1820 [email protected] +44 1223 33 1826


John C. Clark, DSc. PET Science Director


Professor John D. Pickard, Clinical Director and Chairman Dr. Franklin I. Aigbirhio, Radiopharmaceutical Chemist Dr. Peter J. Johnstrom, Radiopharmaceutical Chemist Mr. Paul Burke, Cyclotron Engineer

[3] TYPE OF

CYCLOTRON: Negative ion, fixed energy


1994

MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes No Maximum beam available (µA) 100 40 Typical beam employed (µA) 45 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify): PET






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F peptides; 11C ligands and substrates; 64Cu antibody fragments/chelates [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 3/week to two centres. Yes No


Yes No





389

384


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water CO O2 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


390

385

39. UNITED STATES OF AMERICA

2005 COUNTRY: UNITED STATES OF AMERICA USA-1

[1] INSTITUTE: Bowman Gray School of Medicine Medical Centre Boulevard Winston-Salem, NC 27157


+1 910 716 7461


Dr. Richard L. Witcofski Director


Richard Ehrenkaufer Henry Chilton

[3] TYPE OF



MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-FDG, daily Yes No


Yes No





391

386


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F – FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C - methionine Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq 15O - water OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


392

387


[1] INSTITUTE: Brookhaven National Laboratory Chemistry Department, Bldg. 901 Upton, NY 11973


+631 344 4587 [email protected] +631 344 4587


David J. Schlyer Manager, BNL Cyclotron Facility


Joanna Fowler, Programme Director Richard Ferrieri, Chemist Michael Schueller, Assistant Chemist

[3] TYPE OF

CYCLOTRON: Isochronous YEAR OF:



(II) UPGRADE:


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 2 – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



393

388


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 13.5 95 3.1 45 Yes No

20Ne (d, α)18F 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 3.5 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Cocaine 0.5 3/week Yes No Yes No Raclopride 0.5 3/week Yes No Yes No Deprenyl 0.5 2/week Yes No Yes No Clorgyline 0.5 2/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.0 On demand 160(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 195m Pt

394

389

2005 COUNTRY UNITED STATES OF AMERICA USA-3 [1] INSTITUTE: Brookhaven National Laboratory

Building 901 Upton, NY 11973


(631) 344-4587 [email protected] (631) 344-7350


David J. Schlyer Head, BNL Cyclotron Facility


Michael Schueller Assistant Scientist Richard Ferrieri Chemist

[3] TYPE OF


Negative ion Ebco Technologies Inc. TR19


2002


Beam energies (MeV) 19 10 Yes No Maximum beam available (µA) 100 100 100 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

25 20 5 4 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 0 Radiography: 0









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): New tracers for receptor systems [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence 2 Gamma camera 0 Single photon tomography (SPET) 0 Positron emission tomography (PET) 0 –Clinical 2 –Small animal 2 –Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



395

390


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 13.5 95% 2.3 Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 13.5 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Cocaine 0.5 3/week Yes No Yes No Raclopride 0.5 8/week Yes No Yes No Ritalin 0.5 1/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

ammonia 0.25 1/week 16O (p, a) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


[11C] Jasmonic acid for plant studies

396

391


[1] INSTITUTE: Carolinas Medical Center Department of NM & PET 1000 Blyth Blvd., P.O. Box 32861 Charlotten NC 28232




Dr. Ron Borchert


[3] TYPE OF


INSTALLATION 1993

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes N Maximum beam available (µA) 80 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? Confidential Yes No


Yes No


511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



397

392


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F ~ 37 95 0.5 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 400-450 2-4/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 15 - 22 1-2/week 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


398

393


[1] INSTITUTE: Case Western Reserve University and University Hospitals of Cleveland Division of Radiology 11100 Euclid Avenue, Cleveland, OH 44139




Dr. Marc Berridge Associate Professor


Lei Zheng Ken Voelker

[3] TYPE OF


INSTALLATION 1985

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

25 25 average: 6 (some weeks, none)











If yes and available, name of institution/s & how often? 18F-Fluoride; 13N-Ammonia; 18F-FDG

Yes No


Yes No





399

394


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


400

395


[1] INSTITUTE: Childrens Hospital of Michigan PET Center 3901 Beaubien Boulevard Detroi, MI 48201


+1 313 993 2618 [email protected] +1 313 993 3845


Dr. Thomas J. Mangner Director, PET Chemistry


Dr. Harry T. Chugani, Medical Director

[3] TYPE OF


INSTALLATION 1993

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 20 - 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 20-24 10 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 20 - 24 Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – leucine; 11C - DWAY [9] Do you supply radionuclides to other institutions?



Yes No





401

396


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 22 >95 0.35 150 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 12 5-6/week Yes No Yes No 18F FLT 2 1/week Yes No Yes No 18F FMAU 1.5 1/monoth Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C FMZ 15 2-3/week Yes No Yes No 11C AMT 6 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N NH3 2 5-10/week 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq 15O Water 4 5-6/month 15N(p,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Other radiopharmaceuticals produced on an irregular basis: C-11 acetate, C-11 m-hydroxyephedrine (HED), 2-C-11 thymidine, C-11 methionine, F-18 FAU, F-18 FIAU, F-18 FBAU.

402

397

2005 COUNTRY UNITED STATES OF AMERICA. USA-7 [1] INSTITUTE: Columbia University, Kreitchman PET Center

177 Ft Washington Ave, MHB B1 room 4 New York, NY 10032


(212)923-1555 [email protected] (212)543-8879


Ronald Van Heertum M.D Director Kreitchman PET Center


Norman Simpson, Director Radioisotope & Radioligand Product Dave Wilson, Radiopharmacy Manager

[3] TYPE OF


Negative Ion Medical Cyclotron CTI RDS112


1992 n/a


Beam energies (MeV) 11MeV N/A N/A N/A Yes No Maximum beam available (µA) 120 µA

(spilt beam)

N/A N/A N/A N/A

Typical beam employed (µA) 30-40 N/A N/A N/A N/A [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

75

18F – 15 15O – 0.5 13N – 0.25 11C -15

0 cyclotron research 2 hours chem. Res

20

[6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 40 Radiography: 0












Yes No


511 KeV coincidence 3 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical, Small animal, Plant biochemistry 3 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



403

398


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 81.4 98% 1.2ml 624 Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 40.7 2 Batches/Day Yes No Yes No FPS 3.7 1/month Yes No Yes No Fallypride 3.7 2/month Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

M100907 7.4 2 Batches/week Yes No Yes No Raclopride 7.4 4 Batches/week Yes No Yes No WAY 100635 0.37 2 Batches/week Yes No Yes No DASB .74 2 Batches/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.85 2-3 per week 160(p,α)13N Yes No N/A Yes No N/A Yes No N/A 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Oxygen 3.7 1 Batch every 2-3 months 15N(p,n)15O N/A Water 3.7 2-3 Batches per month 15N(p,n)15O N/A Carbon Monoxide

N/A


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu N/A N/A Yes No Yes No 67Ga N/A N/A Yes No Yes No 86Y N/A N/A Yes No Yes No 94mTc N/A N/A Yes No Yes No 103Pd N/A N/A Yes No Yes No 111In N/A N/A Yes No Yes No 123I N/A N/A Yes No Yes No 124I N/A N/A Yes No Yes No 201Tl N/A N/A Yes No Yes No 211At N/A N/A Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

[C-11]NNC112, [C-11]acetate, [C-11]Palmitate, [C-11]mHED, [C-11]cocaine, [C-11]Carfentil, [C-11]DTBZ, [C-11]McN5652

404

399


[1] INSTITUTE: Creighton University Center for Metabolic Imaging 901 Dorcas Street Omaha, NE 88106


+1 402 346 4181


Dr. Marc Wrichelt Manager


Dr. Mike Harrington Mr. Steve Torres

[3] TYPE OF


INSTALLATION 1989

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

~ 7 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










institutions?

If yes and available, name of institution/s & how often? 18

F-FDG Yes No


Yes No





405

400


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


406

401


[1] INSTITUTE: Crocker Nuclear Laboratory University of California, Davis, 1 Bainer Drive Davis, CA 95616


+1 916 752 1460 [email protected] +1 916 752 0952


Dr. Manuel C. Lagunas-Solar Senior Radiochemist


Mr. Nolan X. Zeng Mr. Carlos M. Castaneda Ms. Krystyna Trzepla-Nabaglo

[3] TYPE OF

CYCLOTRON: 76 inch isochronous YEAR OF:

(I) INSTALLATION 1964-1966

MANUFACTURER: W.M. Brobeck & Associates

(II) UPGRADE:

MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-68 15-45 20-90 16-90 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 1 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

112 4-8 ~ 16 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:



Activation analysis: Other (specify) Food irradiation

& conservation






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F; 205Bi; 206Bi; 67Cu [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Benedict Nuclear Pharmaceuticals, CO. USA – 4/w; University of California, Irvine, CA, USA – 1-2/w; University of California, Berkley, CA, USA –1-2/w; VA Hospital, Palo Alto CA. USA – 1-2/w; National Institute of Health, MD, USA – 2-4/y; NeoRx Corporation, WA, USA – 2-4/y

Yes No


Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



407

402


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3.7 – 7.4 4/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 205Bi, 206Bi

408

403


[1] INSTITUTE: Downstate Clinical PET Center Methodist Medical Center 221 North East Glen Oak Ave. Illinois 61606


+1 309 6724 191 +1 309 6712 166


Dr. Danny Bingham Manager


Brenda Shields

[3] TYPE OF


INSTALLATION 1990

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 20 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often?18F-FDG, 5/week Yes No


Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



409

404


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


410

405


[1] INSTITUTE: Duke University Medical Centre Department of Radiology Box 3808 Durham, NC 27710


+1 919 684 7708 [email protected] +1 919 684 7121


Dr. Bruce Wieland Director, Cyclotron


Dr. Michael Zalutsky, Professor

[3] TYPE OF

CYCLOTRON: Isochronous fixed field, positive ion

YEAR OF: (I)

INSTALLATION 1985


(II) UPGRADE:

MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 27.6 14 28.3 Yes No Maximum beam available (µA) 120 120 100 Typical beam employed (µA) 70 70 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



411

406


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 97 0.4 300 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

ammonia 1 3/week 13C(p,n)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H2O 1 2/week 14N(d,n)15O O2 8 2/week 14N(d,n)15O CO 8 2/week 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 4/week Yes No Yes No 201Tl Yes No Yes No 211At 4 1/week Yes No Yes No COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):

412

407


[1] INSTITUTE: Emory University, Division of Nuclear Medicine 1364 Clifton Road NE Atlanta, GA 30322


+1 404 712 7930


Mark Goodman


Ronald Crowe

[3] TYPE OF


INSTALLATION 1992


production

h/week for

research

h/week for

maintenance

h/week for

applications

30 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No





413

408


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


414

409


[1] INSTITUTE: Gershenson Radiation Oncology Center Harper University Hospital and Wayne State University 3990 John R Detroit, MI 48201


+1 313 745 2487 [email protected] +1 313 745 2314


Dr. Richard L. Maughan


Mark Yudelev, PhD., Senior Clinical Medical Physicist

[3] TYPE OF

CYCLOTRON: 50 MeV deuteron superconducting cyclotron


1990

MANUFACTURER: Michigan State University

(II) UPGRADE:

MODEL: K100-Harper [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 48.5 Yes No Maximum beam available (µA) ~ 20 Typical beam employed (µA) ~ 12 [5] CYCLOTRON OPERATION: Totalhours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications



Physics: (medical) 5 Neutron therapy: 50






Intense neutron beam? (specify average En = ?) Yes No En = 19MeV, 55




Yes No





415

410


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


416

411


[1] INSTITUTE: Good Samaritan Medical Center PET Net Pharmaceutical Services 1111 E. McDowell Road, West Tower, Lower Level 1


+1 602 239 4100/4747 +1 602 239 2810


Dr. Tricia Giurlani PDC Manager


Dr. Michael Lawson Mr. David Stith Mr. Jay Stivers

[3] TYPE OF


INSTALLATION 1990

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40-100 Typical beam employed (µA) 20-100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

15-30 5-10 5-10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? 18F-FDG, daily; 13N-ammonia, 1/month.

Yes No


Yes No





417

412


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


418

413


[1] INSTITUTE: Indiana University Cyclotron Facility 2401 Milo B. Sampson Lane Bloomington, IN 47408


+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645


Dr. John M. Cameron Director


D. Friesel J. Collins G. East

[3] TYPE OF

CYCLOTRON: Separated sector YEAR OF: (I)

INSTALLATION 1975

MANUFACTURER: In-house (II) UPGRADE: MODEL: K200 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 205 Yes N Maximum beam available (µA) 5 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





419

414


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


420

415


[1] INSTITUTE: Indiana University Cyclotron Facility 2401 Milo B. Sampson Lane Bloomington, IN 47408


+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645


Dr. John M. Cameron Director


D. Friesel J. Collins G. East

[3] TYPE OF

CYCLOTRON: Separated sector YEAR OF:


MANUFACTURER: In-house (II) UPGRADE: MODEL: K16 [4] CYCLOTRON CHARACTERISTICS: (Used as injector to K2000). 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 Yes No

Maximum beam available (µA) 20 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





421

416


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


422

417


[1] INSTITUTE: John Hopkins University School of Medicine Division of Nuclear Medicine, PET Center 600 North Wolfe Street, Nelson B1-150 Baltimore, MD 21287


+1 410 955 2916 rfd @jhu.edu +1 410 955 0691


Robert F. Dannais, PhD. Professor, Radiology/Director, PET Center


Hayden T. Ravert, PhD. John L. Musachio, PhD. William B. Mathews, PhD.

[3] TYPE OF


INSTALLATION 2000

MANUFACTURER: GE (II) UPGRADE: The installation of the PETtrace

MODEL: PET Trace represents an upgrace from our previous Scandinotrix MC-16F which is still on-site, but no longer used.

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 75 40 Typical beam employed (µA) 60 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify): Radiotracer

chemistry









Yes No





423

418


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F ~ 90 > 90 1.5 800 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG > 55 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Many 11C ligands

~ 3.7 4/daily Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water On-line, ~ 3 GBq daily 14N(d,n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


424

419


[1] INSTITUTE: Kettering Memorial Hospital Department of Nuclear Medicine and PET 3535 Southern Boulevard Kettering, OH 45429


+1 937 296 7211 +1 937 296 4265


Dr. Joseph Mantil


Dr. Martin Satter

[3] TYPE OF


INSTALLATION 1989

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 25-43 Typical beam employed (µA) 20-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





425

420


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


426

421


[1] INSTITUTE: LA Tech Center UCLA School of Medicine Department of Molecular and Medical Pharmacology and PETNet Pharmaceuticals, Inc.


+1 310 670 1010 [email protected] +1 310 670 2521


Henry C. Padgett, PhD. Managing Director


[3] TYPE OF

CYCLOTRON: Deep Valley YEAR OF: (I)

INSTALLATION 2000

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-111 (2) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-30 20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



427

422


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 95+ ~ 1 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5 days/week Yes No Yes No F-dopa (in progress) Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

[11C] CO2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


428

423


[1] INSTITUTE: Lawrence Berkeley Laboratory Department of Functional Imaging 1 Cyclotron Road, 55-121 Berkeley, CA 94720


+1 510 486 5276 [email protected] +1 510 486 6208


James P. O’Neil Supervisor, Biomedical Isotope Facility


Dr. Thomas F. Budinger Dr. Henry VanBrocklin

[3] TYPE OF


INSTALLATION 1994

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: Prototype(1st built), H+ only, dual beam, 1 fixed 112–style target, 1 8 position

turret assembly 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications



Physics: <10 Neutron therapy:







[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 55Co, 124I, 94mTc, 76Br [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) KLEON Positron emission tomography (PET) ECAT 531 (1) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



429

424


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 9 37

33 > 95

0.3 1

10 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Various 1/week Yes No Yes No 18FMT 1.9 - 3.7 24/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Choline Various 1 week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.1 3/month 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


430

425


[1] INSTITUTE: Mallinckrodt Institute of Radiology Washington University 510 Kingshighway St. Louis, MO


+1 314 362 8435


Professor M.J. Welch Division Head of Radiological Sciences


[3] TYPE OF

CYCLOTRON: Cyclone 30; 4 beam lines


1977 and 1991

MANUFACTURER: IBA, s.a., The Cyclotron Corp., and Japan Steel Works

(II) UPGRADE:

MODEL: CS-15 (3); JSW 168

(1)

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40-50 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify): PET 35









Yes No





431

426


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37-111 95 1.7 1.2

Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 29-60 daily Yes No Yes No Captopi1 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 10 3/week Yes No Yes No Palmitate 8 3/week Yes No Yes No Glucose 1.5 3/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 4-8 Varies 14N(d,n)15O Oxygen 4-8 Varies 14N(d,n)15O CO 4-8 Varies 14N(d,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 15 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 76Br, 66Ga

432

427


[1] INSTITUTE: Massachusetts General Hospital Department of Radiology Boston, MA 02114


+1 617 726 8336 [email protected] +1 617 726 5123


John A. Correia, PhD. Director, Cyclotron Laboratory


Eli Livni, PhD., Radiochemist David Elmaleh, PhD., Radiochemist Alan Fischman, MD, PhD., Physician William Bucekwicz, Cyclotron Engineer

[3] TYPE OF


INSTALLATION 1989

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: Fixed energy, 18 MeV protons, 8.5 MeV deuterons 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18FDG daily, ten local institutions/hospitals.

Yes No


Yes No





433

428


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 80 97+ 1 500 Yes No

20Ne (d, α)18F 1.2 250 16O (α, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 40 daily Yes No Yes No DOPA 0.05 weekly Yes No Yes No Setopirine 0.1-0.5 weekly Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-CFT, Raclopride

Yes No Yes No

Altopene, SCH 50 mCi 10/week Yes No Yes No 11CO 100 mCi 2/week Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N2 100 mCi 10/week 12C(d,n) Yes No 13N2H3 300 mCi 5/week 16O(p, α) Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

C15O2 300 mCi 10/week 14N(d,n) 15O 15O2 300 mCi 2/week 14N(d,n) 15O H21

5O 300 mCi 5/week 14N(d,n) 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.037 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

434

429

COUNTRY: UNITED STATES OF AMERICA USA-23

[1] INSTITUTE: Medi-Physics, Inc. Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080


+1 908 757 0500


Gordon Glass Site Administration Manager


William McClain

[3] TYPE OF

CYCLOTRON: Negative ion, fixed field, fixed freq., var. energy

YEAR OF: (I)

INSTALLATION 1989

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? Proprietary info Yes No


Yes No





435

430


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


436

431


[1] INSTITUTE: Medi-Physics, Inc. Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004


+1 847 3988 400


Thomas Springer Director of Operations


Brian Carus

[3] TYPE OF


YEAR OF: (I)

INSTALLATION 1986

MANUFACTURER: Sumitomo & CGR (II) UPGRADE: MODEL: PV-750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





437

432


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


438

433


[1] INSTITUTE: Medi-Physics, Inc. Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004


+1 847 3988 400


Thomas Springer Director of Operations


Brian Carus

[3] TYPE OF


YEAR OF: (I)

INSTALLATION 1979

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





439

434


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


440

435


[1] INSTITUTE: Medi-Physics, Inc. Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080


+1 847 3988 400


Gordon Glass Site Administration Manager


William McClain

[3] TYPE OF

CYCLOTRON: Positive ion, Azimuthally varying field, isochronous

YEAR OF: (I)

INSTALLATION 1973


(II) UPGRADE:

MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





441

436


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


442

437


[1] INSTITUTE: Mount Sinai Medical Center 4300 Alton Road Miami Beach, FL 33140


+1 305 674 2465 +1 305 674 2428


Dr. Thomas E. Boothe Director, Cyclotron/Radiochemistry


Mike Plitnikes Patricia Smith Manny Tavana

[3] TYPE OF




(II) UPGRADE:

MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

Proprietary Proprietary Proprietary [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? 67Ga-chloride; 111In-chloride; 201Tl-chloride – world wide

Yes No


Yes No





443

438


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


444

439


[1] INSTITUTE: National Institute of Drug Abuse NIDA/IRP, NIH 5500 Nathan Shock Drive, Room 405 Baltimore, MD 21224


+1 410 550 1440 (general)/ +1 410 550 2916 (cyclotron) [email protected] +1 410 550 2724


Alane Kimes, PhD. Acting Branch Chief


Andrew Horti, PhD., Chief Radiochemist Carlo Contoreggi, MD, Authorized Radiation User/Nuclear Medicine Physician

[3] TYPE OF


INSTALLATION 1997


production

h/week for

research

h/week for

maintenance

h/week for

applications

20 0 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0



Activation analysis: 0 Other (specify): 20: PET









Yes No








445

440


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 12-15 95 1.1 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 4-8 1-2/week Yes No Yes No 18F – 2-Fa 1 0-2/week Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 4-8 0-6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

n/a Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 0.7-1 0-30/week 15N(p,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Many research tracers labeled with 11C and 18F.

446

441


[1] INSTITUTE: National Institute of Health Building 10, Room 1C401, MSC 1180 Bethesda, MD 20892


+1 301 496 0345 [email protected] +1 301 402 3521


Dr. William Eckelman Chief, PET Department


Paul S. Plascjak

[3] TYPE OF


INSTALLATION 1999

MANUFACTURER: (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

40 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 40 Radiography:










If yes and available, name of institution/s & how often? ORNL - monthly; NIST - yearly.

Yes No


Yes No





447

442


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 95 1.5 600 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 1/day Yes No Yes No Dopamine 0.3 1/week Yes No Yes No DOPA 0.3 1/week Yes No Yes No FPTZTP 0.2 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Raclopride 1 1/week Yes No Yes No Palmitic acid 1 2/week Yes No Yes No Aracidonic 0.5 4/week Yes No Yes No CO 2 2/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.5 10/week 16O(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water Continuous daily 14N(d, n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 0.75 1/week Yes No Yes No 94mTc 1.0 1/week Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1.5 1/month Yes No Yes No 201Tl Yes No Yes No 211At 1.5 1/month Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

448

443




+1 301 496 0345 +1 301 402 3521




Paul S. Plascjak

[3] TYPE OF

CYCLOTRON: Fixed energy compact

YEAR OF: (I)

INSTALLATION 1985


(II) UPGRADE:

MODEL: JSW-1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 9.8 Yes No Maximum beam available (µA) 150 150 Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

72 (6 days/ week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? 18F FDG provided to one centre 1/week

Yes No


Yes No





449

444


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


6 -18F – Cylofoxy.

450

445




+1 301 496 0345 [email protected] +1 301 402 3521




Paul S. Plascjak

[3] TYPE OF

CYCLOTRON: Fixed energy compact

YEAR OF: (I)

INSTALLATION 1985


(II) UPGRADE:

MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.5 14.8 38.1 29.6 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 60 100 60 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

72 (6 days/week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? 18FDG provided to one centre, 1/week

Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Research/diagnosis on site.

Yes No





451

446


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


6 -18F – Cylofoxy.

452

447

2005 COUNTRY UNITED STATES OF AMERICA USA- 32

[1] INSTITUTE: National Superconducting Cyclotron Laboratory Michigan State University, 1 Cyclotron East Lansing, MI 48824-1321


+1-517-355-9671 [email protected] +1-517-353-5967


Dr. C.-K. Gelbke Director


Dr. Peter S. Miller / Head, Operations Department


Superconducting magnet cyclotron In-house, K1200


1980-1987 1996-2000

[4] CYCLOTRON CHARACTERISTICS: 1200 q2/A2 MeV/nucleon, focusing limit 400 q/A MeV/nucleon 16O 150 MeV/u, 136Xe 120 MeV/u, 209Bi 80 MeV/u for example 1H 2H 3He 4He Dual Beams

Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications





Production of rare isotope

beams by nuclear

fragmentation process








We supply beams of rare isotopes to users, many from other institutions. [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried

out on-site? Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



453

448


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq

if

availabl

e 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


454

449

2005 COUNTRY UNITED STATES OF AMERICA USA-33

[1] INSTITUTE: National Superconducting Cyclotron Laboratory Michigan State University, 1 Cyclotron East Lansing, MI 48824-1321


+1-517-355-9671 [email protected] +1-517-353-5967


Dr. C.-K. Gelbke Director


Dr. Peter S. Miller / Head, Operations Department


Superconducting magnet cyclotron In-house, K500


1977-1981 1996-2000

[4] CYCLOTRON CHARACTERISTICS: 520 q2/A2 MeV/nucleon, focusing limit 160 q/A MeV/nucleon 1H 2H 3He 4He Dual Beams

Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

156 156 12 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week

Radiobiology: Radiography:




Injector for K1200cyclotron









Yes No





455

450


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


456

451


[1] INSTITUTE: North Shore University Hospital Research Department - Cyclotron/ PET Facility 350 Community Drive Manhasett, NY 11021


+1 516 562 1055 [email protected] +1 516 562 1120


Dr. J. Robert Dahl


Thomas Chaly

[3] TYPE OF


INSTALLATION 1987

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 8.75 17.5 Yes No Maximum beam available (µA) 180 180 Typical beam employed (µA) 30-40 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20 20 4, plus 2 weeks/year for periodic maintenance











If yes and available, name of institution/s & how often? Only to research collaborators with continuing joint projects.

Yes No


Yes No





457

452


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


458

453


[1] INSTITUTE: Northern California PET Imaging Center 3195 Folsom Boulevard Sacramento, CA 95816


+1 916 737 3200


Dr. Peter Valk


Mason Jones

[3] TYPE OF


INSTALLATION 1992


production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-FDG, 1/month Yes No


Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



459

454


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N-ammonia Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq 15O-water OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


460

455


[1] INSTITUTE: Oak Ridge National Laboratory Bldg. 6000, MS 6368 Oak Ridge, TN 37831-6368


+1 423 574 4111 +1 423 574 1268


B.A. Tatum Engineering Manager


S.W. Mosko

[3] TYPE OF

CYCLOTRON: K=100 Isochronous YEAR OF: (I)

INSTALLATION 1960

MANUFACTURER: ORNL (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) < 60 < 40 Yes No Maximum beam available (µA) < 100 < 200 Typical beam employed (µA) < 50 < 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





461

456


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


462

457


[1] INSTITUTE: PET Net - Chicago 200 E. Howard Street No. 240 Des Plaines, IL 60018


+1 847 297 1322


Mr. Russ Greenberg Manager


Clyde Cole

[3] TYPE OF


INSTALLATION 1995


production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-FDG, 5 × per week Yes No


Yes No





463

458


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


464

459


[1] INSTITUTE: PETNet Pharmaceutical Services 1350 Manufacturing Drive, Suite 105 Dallas, TX 75207


+1 214 741 2075 [email protected] +1 214 741 9323


Mr. Steve Torres


[3] TYPE OF


INSTALLATION 2001


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





465

460


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 133 96 1.3 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


466

461


[1] INSTITUTE: PETNet Pharmaceutical Services 1350 Manufacturing Drive, Suite 105 Dallas, TX 75207


+1 214 741 2075 [email protected] +1 214 741 9323


Mr. Steve Torres


[3] TYPE OF


INSTALLATION 1999


production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





467

462


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 133 96 1.3 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


468

463


[1] INSTITUTE: PET Net/VAMC Palo Alto Nuclear Medicine Service (115) 3801 Miranda Avenue




Dr. Henry C. Padgett Manager


Dave Wilson

[3] TYPE OF


INSTALLATION 1996


production

h/week for

research

h/week for

maintenance

h/week for

applications

5-15 5-15 ~ 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 2-3/ week Yes No


Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



469

464


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


470

465


[1] INSTITUTE: Regional Nuclear Pharmaceutical, LLC 1224 3rd Avenue South University Park Birmingham, Alabama 35233


+1 205 322 4252 [email protected] +1 205 322 4859


Mr. John Haynes Director of Operations


[3] TYPE OF


INSTALLATION 2000


production

h/week for

research

h/week for

maintenance

h/week for

applications




Activation analysis: Other (specify): 18

F production

25/week







If yes and available, name of institution/s & how often? New Orleans, Regional PET; Memphis Regional PET; Jeff Anderson Regional Medical Centre.

Yes No


Yes No





471

466


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 >95 1 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 55 2/day Yes No Yes No $750/

dose Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


472

467


[1] INSTITUTE: Saint Louis University Health Sciences Center, School of Medicine Division of Nuclear Medicine 3635 Vista Avenue at Grand Blvd. P.O. Box 15250 St. Louis, MO 63110-0250


+1 314 577 8801 +1 314 268 5486


Dr. Ranajit K. Bera Assistant Professor


Dr. James W. Fletcher, Director

[3] TYPE OF


INSTALLATION 1991


production

h/week for

research

h/week for

maintenance

h/week for

applications





Radiopharmaceuticals

20 h/week









Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Advanced – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



473

468


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 95 0.38 140 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 15-20 everyday Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13NH3 0.8 13C(p,n)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H215O 15 15N(p,n)15O


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F - Cyclofoxy

474

469


[1] INSTITUTE: Saint Joseph's Positron Center 3003 W. Dr. Martin Luther King, Jr. Boulevard Tampa, FL 33607-4227


+1 813 876 5620


John Mather


Kathie Krista Mike Mosley John O'Connen

[3] TYPE OF


INSTALLATION 1989


production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-FDG, 5 days/week Yes No


Yes No





475

470


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


476

471


[1] INSTITUTE: State University of New York at Buffalo Department of Nuclear Medicine 105 Parker Hall, 3435 Main Street Buffalo, NY 14214-3007


+1 716 838 5889 [email protected] +1 716 838 4918


Prof. R. E. Ackerhalt Director of the Cyclotron Facility


Michael S. Haka

[3] TYPE OF



MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 0-450 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

164 8 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 103 Pd [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F-FDG VA, daily; 13N-ammonia, weekly; -18F-FDG, MFH 3-4 x/week/Roswell 1/week/Biomedical Research, 1-2/week

Yes No


Yes No





477

472


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water CO OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Cu, 62Zn

478

473

2005 COUNTRY UNITED STATES OF AMERICA USA-45

[1] INSTITUTE: Texas A&M University Cyclotron Institute College Station, TX 77843


979-845-1411 [email protected] 979-845-1899


Robert Tribble Director


Don May Fred Abegglen George Kim Henry Clark

[3] TYPE OF


K500 Superconducting TAMU K500


1988 none


Beam energies (MeV) 10-70 MeV/nuc

55-70 MeV/nuc 25-40 MeV/nuc

15-70 MeV/nuc

Yes No

Maximum beam available (µA) 0.2 1 1 1 Typical beam employed (µA) 0.01 0.01 0.01 0.05 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radionuclide

production


maintenance

Hours/week for

applications

168 0 69% 1% 30% [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 0 Radiography: 0

Materials science: 30% Proton therapy: 0

Physics: 69% Neutron therapy: 0

Activation analysis: 0 Other (specify) 1%









Yes No





479

474


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being

produced)

480

475


[1] INSTITUTE: The Christ Hospital 2139 Auburn Avenue Cincinnati, OH 45219


+1 513 585 0836 [email protected] +1 513 585 0835


Mr. Thomas G. Kemme Manager


Ms. Carla C. Pemberton, RPh. Mr. George H. Day, RPh.

[3] TYPE OF


INSTALLATION 1991


production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- FDG, 13NH3

[9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? University of Cincinnati – 2/week; Fort Hamilton Hughes Hostpital – 1/month; Proctor & Gamble – 1/month

Yes No


Yes No





481

476


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 32 > 95 0.33 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 10 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 30 1-2/yr Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 1.2 1/week Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


482

477


[1] INSTITUTE: The Queen's Medical Center 1301 Punchbowl Street Honolulu, HI 96813


+1 808 537 7077 [email protected] +1 808 585 5095


Pat McGuigan Manager


Marc Coel, MD

[3] TYPE OF


INSTALLATION 1998

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) (yes) Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications










[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [F-18] Choline [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Tripler Hospital and Kuakini Hospital

Yes No


Yes No





483

478


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F > 95 1.1 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


[F-18] Choline

484

479


[1] INSTITUTE: Theragenics Corporation 5325 Oakbrook Parkway Norcross, GA 30093


+1 770 381 8447


Tony Longo Cyclotron Facility Manager


Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung

[3] TYPE OF


INSTALLATION 1996

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18+ [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 Yes No Maximum beam available (µA) various Typical beam employed (µA) N/A [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

144-168 Typical 0-36 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? Medical; Typical 1 to 10 / month/ client

Yes No


Yes No





485

480


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd 10 - 60 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Brachytherapy

486

481




+1 770 3818 447




Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung

[3] TYPE OF




production

h/week for

research

h/week for

maintenance

h/week for

applications












Yes No


Yes No





487

482


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


488

483




+1 770 381 8447




Tom West; Ty Robin Joe Rodgers; J. Hwung

[3] TYPE OF




production

h/week for

research

h/week for

maintenance

h/week for

applications












Yes No


Yes No





489

484


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


490

485


[1] INSTITUTE: University of California at Los Angeles Biomedical Cyclotron 10833 Le Conte Avenue Los Angeles, CA 90095


+1 310 825 6231 +1 310 825 4517


N. Satyamurthy


[3] TYPE OF


INSTALLATION 1994


production

h/week for

research

h/week for

maintenance

h/week for

applications

40 20 10 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Several 18F and 11C labeled radiopharmaceuticals [9] Do you supply radionuclides to other institutions?



Yes No





491

486


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 40 95 0.8 15 750 5 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 20 10/week Yes No Yes No Variety of 18F-labeled prods.

10/week Yes No Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-Acetate 10 2/week Yes No Yes No Variety of 11C-labeled prods.

4/week Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 3 20/week 16O(p, α) 13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H2O 4 10/week 15N(p, n) 15O O2 4 3/week CO 4 3/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


492

487


[1] INSTITUTE: University of California-Irvine Brain Imaging Centre Irvine, CA 92697


+1 714 824 2018 [email protected] +1 714 824 2230


Dr. Ahmod A. Najafi


[3] TYPE OF

CYCLOTRON: Positive ion YEAR OF


MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 8-10 Yes No Maximum beam available (µA) 20 Typical beam employed (µA) 2-3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

12 12 2 -3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) (yes) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



493

488


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


494

489


[1] INSTITUTE: University of Iowa PET Imaging Centre Iowa City, IA 52242


+1 319 356 4100 [email protected] +1 319 353 6512


Professor Richard D. Hichwa Director


G. Leonard Watkins Laura Boles Ponto Mark T. Madsen

[3] TYPE OF

CYCLOTRON: Positive ion, sector-focused, resistive magnet

YEAR OF: (I)

INSTALLATION 1990

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 7.3 (fixed energy) Yes No Maximum beam available (µA) 1-70 1-70 Typical beam employed (µA) 25-50 100

max 10-15 100 max

[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

> 40 20-30 < 1 target maintenance 1/year












[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Medical research/diagnosis

Yes No





495

490


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Mehionine Yes No Yes No Acetate Yes No Yes No CO, CO2 Yes No Yes No Receptor ligands

Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water CO, CO2 O2 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 48V

496

491


[1] INSTITUTE: University of Michigan 3480 Kresge III Ann Arbor, MI 48109-0552


+1 313 763 9244 +1 313 764 0288


Professor Michael R. Kilbourn Director, PET Chemistry


Dr. Robert Koeppe Mr. James Moskwa

[3] TYPE OF

CYCLOTRON: Medical YEAR OF:



(II) UPGRADE:

MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.0 15.0 38.0 30.0 Yes No Maximum beam available (µA) 200 300 100 90 Typical beam employed (µA) 30 30 50 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications













Yes No





497

492


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

Bq 18FDG Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Epinephrine Yes No Yes No Pseuolophedrine Yes No Yes No Diahydiotetabenazine

Yes No Yes No

Acetate Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Zn

498

493

2005 COUNTRY UNITED STATES OF AMERICA USA-55 [1] INSTITUTE: University of Pennsylvania

Department of Radiology 420 Curie Blvd Philadelphia, PA 19104


215-662-7550 [email protected] 215-662-7551


Richard Freifelder, Ph.D. Senior Research Investigator, Cyclotron Facility Manager


Joel S. Karp, Ph.D. Harry White Larry Toto


Positive Ion Japan Steel Works 3015 BC


1985


Beam energies (MeV) 18, 22, 30 11 Yes No Maximum beam available (µA) 30 15 Typical beam employed (µA) 10-15 10 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week or

radioproduction


maintenance

Hours/week for

applications




Activation analysis: Other (specify)PET Tracers 30






[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18-F, 11-C Choline, FIAU, Fallypride, 11-C Cartentenil [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 5 Positron emission tomography (PET) 5 – Clinical 4 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



499

494


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 55 97 0.6 cc 250 g Yes No

Ne (d, α) 18F 3.7 50 cc Ne gas

16O (α, x) 18F n/a 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 18 Daily Yes No Yes No 18F-DOPA 0.37 Once/week Yes No Yes No 18F-FHBG 0.19 Once/week Yes No Yes No 18F-FLT 0.19 Once/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C-Raclopride

0.19 Once/month Yes No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq 13N-ammonia 3.7 Once/month 12C(p,n)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


EF5 (18-F) 15-O water 18-F NaF

500

495


[1] INSTITUTE: University of Southern California 1510 San Pablo, #350 Los Angeles, CA 9003


+1 213 342 5884 [email protected] +1 213 342 5778


Dr. Peter S. Conti Director, PET Imaging & Radiological Resources


James R. Bading; Miar Alauddin Mr. John Fissikis; Mr. Keith Higa

[3] TYPE OF




Maximum beam available (µA) 150 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-FDG daily Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on and off site

Yes No





501

496


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water O CO, CO2 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


502

497


[1] INSTITUTE: University of Tennesse Medical Centre Biomedical Imaging Center 1924 Alcoa Highway, Knoxville, TN 37920


+1 865 544 9818 or 865 544 9697 [email protected] OR [email protected] +1 865 544 8395


C.P.D. Longford Manager


K.F. Hubner

[3] TYPE OF



MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 2000 - two (2) high pressure target; APS power supply upgraded

2001 - new main magnet power supply - solid state; new automated chemistry equipment

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.2 Yes No Maximum beam available (µA) Typical beam employed (µA) 32/target [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

30-40 30-40 1-2 4-8 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:










If yes and available, name of institution/s & how often? Daily deliveries of 18FDG to hospitals within 4-5 km radius. Currently have 20 customers, shipping up to 20 doses/day with planned expansion to ship 60 doses/day.

Yes No


Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



503

498


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 65 > 94 0.90 5 1200 None Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 30-60 2-3/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

ACBC 3.0 5-10/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Planned: 18F -BPA and DOPA – not yet available.

504

499

2005 COUNTRY: UNITED STATES OF AMERICA USA-58 [1] INSTITUTE: University of Texas Houston

6431 Fannin Street, Houston, TX 77030 TELEPHONE NO.:


+1 713 500 7755 [email protected] +1 713 500 7771


Carlos Gonzalez Lepera Associate Professor and Executive Director

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION

Nancy Haberman, Chemist Kevin Grilley, Radiopharmacist Russell Hildebrandt, Radiopharmacist Isidoro Vaquila, Cyclotron Engineer David Andews, Cyclotron Operator

[3] TYPE OF

CYCLOTRON: Variable energy isochronous


1983

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 40 Yes N Maximum beam available (µA) 150 40 30 Typical beam employed (µA) 40 15 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications






Calibration sources? (specify which & quantity) Yes No 22Na, 0.037

GBq




[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I , 211At [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Hospitals and PET Centres throughout Southeast Texas

Yes No


Yes No





505

500


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 100 95 1.4 300 Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 50 2/day Yes No Yes No NaF 50 1/day Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 6/day 160(p, α)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 4 1/day 14N(d, n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga 555 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 370 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

506

501


[1] INSTITUTE: University of Texas Research Imaging Center Health Science Center, San Antonia 7703 Floyd Curl Drive San Antonio, TX 78284


+1 210 567 8190 [email protected] +1 210 567 8152


Dr. Peter Fox Director


Paul Jerabbk

[3] TYPE OF

CYCLOTRON: Fixed energy, isochronous, positive ion


1991

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.2 8.6 Yes N Maximum beam available (µA) < 10 < 10 Typical beam employed (µA) 10-50 10-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

3-5 3-5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:












Yes No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 - Clinical - Small animal - Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



507

502


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate Yes No Yes No Methionine Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


508

503

2005 COUNTRY: UNITED STATES OF AMERICA SA-60

[1] INSTITUTE: University of Washington Medical Centre Department of Radiation Oncology Box 356043, Room NN-136, 1959 NE Pacific Street Seattle, WA 98195-6043


+1 206 548 4136 [email protected] +1 206 548 6218


Dr. Ruedi Risler Senior Cyclotron Engineer


Professor Kenneth A. Krohn Professor Jeanne A. Link

[3] TYPE OF

CYCLOTRON: Compact room temperature cyclotron


1983

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50.5 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications









Intense neutron beam? (specify average En = ?) Yes No 35

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C, 15O, 13N, 86Y, 99Tc, 124I, 19Ne [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence 0 Gamma camera 6 Single photon tomography (SPET) 2 Positron emission tomography (PET) 1 –Clinical 1 –Small animal –Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



509

504


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15-20 95 3 No 60 None Yes No

Ne (d, α) 18F No 16O (α, x) 18F No 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5 2/day Yes No Yes No FES 1 3/month Yes No Yes No FM180 1 3/month Yes No Yes No FLT 1 3/month Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Glucose 1 1/month Yes No Yes No Thyamidine 1 3/momth Yes No Yes No MHED 1 4/month Yes No Yes No CGP12177 2 8/month Yes No Yes No Flumazenile 1 1/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

H2O O2 OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2/yr Yes No Yes No 94mTc 2/yr Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I planned Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)

510

505

2005 COUNTRY UNITED STATES OF AMERICA USA-61 [1] INSTITUTE:

MEDICAL PHYSICS DEPARTMENT UNIVERSITY OF WISCONSIN, 1530 MEDICAL SCIENCE CENTER 1300 UNIVERSITY AVE, MADISON, WI, 53706, A


608-263-3910 [email protected] FAX 608-262-2143


RJ Nickles Professor of Medical Physics


Brad Christian, Assistant Professor of Medical Physics Onofre DeJesus, Professor of Medical Physicss


11 MeVproton CTI Inc 112 (first prototype)


1985 2005

[4] CYCLOTRON CHARACTERISTICS: 11 MEV PROTON, NEGATIVE ION, 50 MICROAMPS ONTO 4 TARGET POSITIONS, ONE A VERTICAL BEAM PORT FOR MOLTEN TARGETS 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 11 Yes x No Maximum beam available (µA) 50 Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week or

radiopoduction


maintenance

Hours/week for

applications

10-20 10 5 2 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:



Activation analysis: Other (specify) teaching




X ray sources? (specify which & quantity) Yes x No Ce-139

Intense neutron beam? (specify average En = ?) Yes x No Protons on Be-9

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Br-76, Cl-34m, O-14, [9] Do you supply radionuclides to other institutions?


Stanford (monthly) TRIUMF (soon to start) [10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out

on-site? Yes x No


511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) –Clinical, Small animal, Plant biochemistry 2 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? [F-18] atrazine (Roundup) leachng into ground water

Yes x No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes x No [14] Is the cyclotron used for targetry development? Yes x No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes x No [16] Does your institute accept IAEA research fellows for training/experience? Yes x No

511

506


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 30-50% 0.9 ml 20 ml 100 30 Yes No

Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Purchase

commercially Yes No Yes No

F-DOPA, FMT 3 30 Yes x No Yes No fallypride 2 50 Yes x No Yes No Fatty acids 2 2 Yes x No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

SCH 23,390 2 10 Yes x No Yes No Raclopride 2 15 Yes x No Yes No PK 11195 2 15 Yes x No Yes No Methy- phenidate

2 15 Yes x No Yes No


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NH3 4 5 Protons on O-16 water Yes No x Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 20-40 10 Yes x No Yes x No $162/

GBq 67Ga Yes No Yes No 86Y 2 5 Yes x No Yes No 94mTc 4 5 Yes x No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.2-0.4 10 Yes x No Yes x No 201Tl Yes No Yes No 211At Yes No Yes No [17] COMMENTS:(e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

Over the period of 1971 to the present, about 120 radioisotopes have been studied, making about over hundred labeled compounds. (Nickles RJ, . Production of a Broader Palette of PET Tracers. J Lab Comp Radiopharmaceuticals 46, 1-27: 2003

512

507


[1] INSTITUTE: VA Medical Centre (11P) 1 Veterans Drive Minneapolis, MN 55417


+1 612 725 2230 [email protected] +1 612 725 2068


Dr. David Rotenberg


Mr. Rashid Syed Ms. Carroll Arnett E. Akguen Munawwar Sajjad

[3] TYPE OF


INSTALLATION 1985

MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 Yes N Maximum beam available (µA) 40 50 Typical beam employed (µA) 25 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











institutions?


Yes No


Yes No





513

508


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15 > 95 1.2 100 Yes No

Ne (d, α) 18F 11 99.999 16O (α, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 1.8 on demand Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 2.2 5/week 16O(p,a)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq 15O Water 6.0 36/week 14N(d,n)15O 14O Water 3.5 on demand 14N(p,n)14O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


514

509


[1] INSTITUTE: VAMC & University of Pittsburgh Medical Facility PET Center -9B 200 Lothrop Street Pittsburg, PA 15213


+1 412 647 0736 [email protected] +1 412 647 0700


Professor Chet Mathis Co-Director, PET Facility


Professor David Townsend, Co-Dir., PET Facility

[3] TYPE OF




production

h/week for

research

h/week for

maintenance

h/week for

applications

35 20 15 <5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Many, various – 11C-CFT, 11C-acetate and choline [9] Do you supply radionuclides to other institutions?



Yes No


511 KeV coincidence 3 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 + 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



515

510


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 22 > 95 0.3 200 YeNo


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 7 5/week Yes No Yes No 18F-Altanarin 2 2/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Flumezenil 4 1/week Yes No Yes No McN 5652 4 2/week Yes No Yes No Way 100635 1 4/week Yes No Yes No PMD 4 4/week Yes No Yes No Raclopride 3 10/week Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NH3 3 4/week 16O(p,a)13N Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

H2O 4-20 20/week O2 4-10 5/week 15N(p,n)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


516

511

2005 COUNTRY: UNITED STATES OF AMERICA USA-64 [1] INSTITUTE: Vanderbilt University Medical Center

Radiology Department 100 Medical Center South Nashville, TN 3723206315




Dr. Ronald G. Manning


Jeff Clanton Jeff Clauton, ominique Delbeke Robert Kessler

[3] TYPE OF


INSTALLATION 1989

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? PETNet Site; Several Customers >15

Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on & off sites.

Yes No


511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



517

512


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBqe 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


518

513

2005 COUNTRY: UNITES STATES OF AMERICA USA-65

[1] INSTITUTE: Weill Medical College at Cornell University and Memorial Sloan Kettering Cancer Center Consortium 1300 York Avenue New York, NY 10021


+1 212 639 2458 [email protected] +1 212 717 3821


Dr. Ron Finn Head, Cyclotron Division


Yiauchung Sheh, MS, Senior Cyclotron Engineer

[3] TYPE OF

CYCLOTRON: Negative Ion YEAR OF:

(I) INSTALLATION Ongoing and in progress (2001)

MANUFACTURER: EBCO Industries (II) UPGRADE: Incorporation of external beam

MODEL: TR 19/9 line with target changer [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications


Materials science: 10% anticipated Proton therapy:



Radionuclide preparation

90% anticipated







If yes and available, name of institution/s & how often? On scientific collaborative basis Yes No


Yes No





519

514


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F >95 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 69Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Imaging Center building completion scheduled for October 2001. Cyclotron already in vault, awaiting building service availability for start of the assembly.

520

515


[1] INSTITUTE: West Virginia University Hospital PET Centre P.O. Box 9236 Morgantown, WV 26506-9236


+1 304 293 7798 [email protected] +1 304 293 7142


Dr. Naresh C. Gupta Director


Mr. Samuel M. Mazza Mr. Raymond R. Raylman

[3] TYPE OF

CYCLOTRON: Negative ion, dual beam


1995

MANUFACTURER: General Electric (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications











If yes and available, name of institution/s & how often? 18F-Fluoride – irregularly; 18F-FDG - planned

Yes No


Yes No





521

516


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)



(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


522

517


[1] INSTITUTE: William Beaumont Hospital Department of Nuclear Medicine 3601 West Thirteen Mile Road Royal Oak, MI 48083-6769


+1 313 551 831


Dr. Ram B. Sharma Radiochemist


[3] TYPE OF




Maximum beam available (µA) 40 Typical beam employed (µA) 20-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

13 13 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Nucl. Med. 40 Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C and 15O [9] Do you supply radionuclides to other institutions?



Yes No





523

518


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 30 95-98 0.3 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 16/batch 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBqle 13NH3 1.9 2/month Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


524

519


[1] INSTITUTE: Yale University/VAMC West Haven PET Imaging Center (115A) 950 Campbell Avenue West Haven, CT 06516




Dr. Pradeep Garg Director, Radiopharmaceutical Chemistry


[3] TYPE OF




production

h/week for

research

h/week for

maintenance

h/week for

applications

30-40 ~ 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography:









[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- labeled androgens, 18F- labeled prostate probes [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yale University and VA Nuclear Medicine: 0-2 times/month

Yes No


Yes No





525

520


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F ~16 >98 0.32 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 5 - 6 4 - 10/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia ~1 1-10/month 16O(p,a)13N Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 3-4 0-40/week OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NNC 112, Dolipram, Tropanes; 18F Deutero-Altanserine, para fluoro benzylguanidine, Fallypride.

526

521

2005 COUNTRY UNITED STATES OF AMERICA USA-69 [1] INSTITUTE: Cyclo-Tech, LLC

7650 First Place, Oakwood Village, OH 44146 TELEPHONE NO.:


440-439-5356 [email protected] 440-439-5403


Marc Berridge, Ph.D., President


Ken Voelker / VP Cyclotron Engineering Bonnie Bennington / VP Production

[3] TYPE OF CYCLOTRON: MANUFACTURER: MODEL:

PET-Trace GE PETtrace


2002 N/A

[4] CYCLOTRON CHARACTERISTICS: 17 MeV proton, 8 MeV deuteron, Negative ion 1H 2H 3He 4He DualBea Beam energies (MeV) 17 8 na na Yes Maximum beam available (µA) 60 40 Typical beam employed (µA) 50 20 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week

application 25 21 4 8 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week

Radiobiology: 0 Radiography: 0




[7] Is the cyclotron used to produce:

Calibration sources? (specify which & quantity) Yes G No G n

Mössbauer sources? (specify which & quantity) Yes G No G n

X ray sources? (specify which & quantity) Yes G No G n

Intense neutron beam? (specify average En = ?) Yes G No G n

[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): I-124, Cu-64 [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Y


Y

[11] Type of imaging equipment available on-site Number

511 KeV coincidence Gamma camera Positron emission tomography (PET) –Clinical, Small animal, Plant biochemistry 0.1 (Shared Mobile) [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural

applications such as plant biochemistry/research? N

[13] Is the cyclotron used for nuclear reaction cross-section measurements? N [14] Is the cyclotron used for targetry development? Y [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? N [16] Does your institute accept IAEA research fellows for training/experience?

527

522


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 2.5 Ci 95 1.3 mL 100g Y

Ne (d, ) 18F na 16O (, x) 18F na 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBqe 18FDG 50% (uncorr) Y Y na Fluorocarazolol 40% 1/mo Y Y fluticasone propionate

40% 18/mo Y Y

6-FDG 50% 4/mo Y Y etc 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Topotecan 15% 1/mo Y Y Nicotine 85% 2/mo Y N Various Steroids 70% 2/mo Y N Raclopride 70% 1/mo Y N etc 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 0.8 Ci 20/mo O-16 (p,alpha) Y Nitrogen 0.8 Ci 1/mo O-16 (p,alpha) N Yes G No G 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 0.5 Ci N-14 (d,n) CO 0.5 Ci Butanol 0.15 Ci OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes G No G Yes G No G 67Ga Yes G No G Yes G No G 86Y Yes G No G Yes G No G 94mTc Yes G No G Yes G No G 103Pd Yes G No G Yes G No G 111In Yes G No G Yes G No G 123I Yes G No G Yes G No G 124I Yes G No G Yes G No G 201Tl Yes G No G Yes G No G 211At Yes G No G Yes G No G

528

523

2005 COUNTRY UNITED STATES OF AMERICA USA-70 [1] INSTITUTE: CYCLOTOPE – Accelerated Medicine

8285 El Rio, Suite 160 Houston, TX 77054


(713) 747-5686 [email protected] (713)747-4858


Carlos Gonzalez President


Roberto Strangis, Cyclotron Engineer


Negative Ion ACS TR19/9


2002


Beam energies (MeV) 18 9 Yes X No Maximum beam available (µA) 350 50 Typical beam employed (µA) 100 40 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week for

radioproduction


maintenance

Hours/week for

applications

[6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: Radiography:












Yes No X





529

524


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)


Ne (d, α) 18F


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Daily Yes No X Yes X No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


530

531

02-3

1581

532

Documents

Directory of Cyclotrons used for Radionuclide Production in Member