Dilution of Antibiotics

8/12/2019 Dilution of Antibiotics

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DILUTION OF ANTIBIOTICS

Sr No. Constituent Antibiotic Strength Diluent for Constitution Vol of I.F Infusion Fluids

1 Amoxycillin+Clavulinic acid Inj Augpen 150 mg IV 5 ml S.W within 20 minutes of reconstitution

300 mg IV 5 ml S.W within 20 minutes of reconstitution

600 mg IV infusion 10 ml S.W 50 ml S.W, N.S (0.9% w/v)

1.2 g IV infusion 20 ml S.W 100 ml S.W, N.S (0.9% w/v)

2 Ampicillin Inj Biocillin 100 mg 3ml S.W For IM, 5ml S.W For IV500 mg 3ml S.W For IM, 5ml S.W For IV

3 Azithromycin Inj Azee 500 mg 4.8 ml S.W for 1mg/ml 500 ml N.S (0.9, 0.45%), 5%D

for 2mg/ml 250 ml

4 Aztreonam Inj Azactum 2 g 6-10 ml S.W, 0.9%NaCl S.W, N.S (0.9% w/v)

5 Bleomycin Inj Bleocip 5 ml IM 1-5 ml S.W, 0.9%NaCl S.W, N.S (0.9% w/v)

5 ml =15 units 5 ml IV 5 ml S.W S.W, N.S (0.9% w/v)

60 units IP 5 ml N.S 50-100 ml N.S (0.9% w/v)

6 Cefazolin Inj Reflin 250 mg 2 ml S.W

500 mg 2 ml S.W

1 g 5 ml S.W

7 Cefipime Inj Novapime 500 mg IV 5 ml S.W S.W, N.S (0.9% w/v), 5%, 10% D

500 mg IM 1.3 ml S.W

1 g IV 10 ml S.W

1 g IM 2.4 ml S.W

2 g 10 ml S.W

8 Cefipime Inj Maxipime 2 g 10 ml S.W, N.S, 5%D 50-100 ml N.S (0.9% w/v), sterile water, 5% D

9 Cefipime+Tazobactum Inj Actamase 1000/125 mg 3ml S.W For IM

10ml S.W For IV

10 Cefipirome Inj Cefrom 1 g 10ml water for injection 100 ml N.S (0.9% w/v)

11 Cefoperazone+sulbactum Inj Cefmate 1 g Diluent in the pack (N.S 0.9%) Diluent in the pack (N.S 0.9%)

2 g Diluent in the pack (N.S 0.9%) Diluent in the pack (N.S 0.9%)

12 Cefoperazone+Sulbactum Inj Lactagard 750 mg 2 ml S.W, N.S, 5% D 20 ml N.S (0.9% w/v), 5%D, S.W

1.5 g 4 ml S.W, N.S, 5% D 20 ml N.S (0.9% w/v), 5%D, S.W

3 g 8 ml S.W, N.S, 5% D 20 ml N.S (0.9% w/v), 5%D, S.W

13 Ceftriaxone Inj Monocef 250 mg IM 0.9 ml S.W, 0.9%NaCl, 5%D

IM = 250 mg/ml 500 mg IM 1.8 ml S.W, 0.9%NaCl, 5%D

1 g IM 3.6 ml S.W, 0.9%NaCl, 5%D

2g IM 7.2 ml S.W, 0.9%NaCl, 5%D


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IV = 100 mg/ml 250 mg IV 2.4 ml S.W, 0.9%NaCl, 5%D as per need N.S (0.9% w/v), S.W, 5%,10% D

500 mg IV 4.8 ml S.W, 0.9%NaCl, 5%D as per need N.S (0.9% w/v), S.W, 5%,10% D

1 g IV 9.6 ml S.W, 0.9%NaCl, 5%D as per need N.S (0.9% w/v), S.W, 5%,10% D

2g IV 19.2 ml S.W, 0.9%NaCl, 5%D as per need N.S (0.9% w/v), S.W, 5%,10% D

14 Cefotaxime Inj Taxim 125 mg 2 ml S.W

500 mg 2 ml S.W

1 g 4 ml S.W

15 Ceftazidime Inj Fortum 250 mg IM 1 ml S.W

500 mg IM 1.5 ml S.W

1 g IM 3 ml S.W

2 g IM 10 ml S.W

250 mg IV 2.5 ml S.W

500 mg IV 5 ml S.W

1 g IV 10 ml S.W

2 g IV 10 ml S.W

1 g IV infusion 10 ml S.W 50 ml Sterile water

2 g IV infusion 10 ml S.W 50 ml Sterile water

16 Ceftriaxone Inj Oframax for 250 mg/ml

250 mg IM 0.9 ml S.W, N.S, 5 %, 10%D

500 mg IM 1.8 ml S.W, N.S, 5 %, 10%D

1 g IM 3.6 ml S.W, N.S, 5 %, 10%D

2 g IM 7.2 ml S.W, N.S, 5 %, 10%D

250 mg IV infusion 2.4 ml S.W, N.S, 5 %, 10%D 50-100 ml N.S (0.9% w/v), S.W, 5% D, 10% D

500 mg IV infusion 4.8 ml S.W, N.S, 5 %, 10%D 50-100 ml N.S (0.9% w/v), S.W, 5% D, 10% D

1 g IV infusion 9.6 ml S.W, N.S, 5 %, 10%D 50-100 ml N.S (0.9% w/v), S.W, 5% D, 10% D

2 g IV infusion 19.2 ml S.W, N.S, 5 %, 10%D 50-100 ml N.S (0.9% w/v), S.W, 5% D, 10% D

17 Ceftriaxone+Sulbactum Inj Formic 375 mg IV 3 ml S.W for injection

750 mg IV 5 ml S.W for injection

1.5 g IV 10 ml S.W for injection

375 mg IM 1 ml S.W for injection

750 mg IM 2 ml S.W for injection

1.5 g IM 5 ml S.W for injection

18 Ceftriaxone+Tazobactum Inj Cefoprox XP 250 mg IV 2.4 ml S.W, N.S, 5%D

500 mg IV 4.8 ml S.W, N.S, 5%D

1 g IV 9.6 ml S.W, N.S, 5%D

250 mg IM 0.5-0.9 ml S.W, N.S, 5%D

500 mg IM 1.0-1.8 ml S.W, N.S, 5%D

1 g IM 2.1- 3.6 ml S.W, N.S, 5%D

19 Cefuroxime Inj Supacef 250 mg IV 2 ml S.W

750 mg IV 6 ml S.W

1.5 g IV 15 ml S.W

250 mg IM 1 ml S.W


3/8

750 mg IM 3 ml S.W

1.5 g infusion 15 ml S.W 50 or 100 ml N.S (0.9% w/v), 5%,10% D

20 Clarithromycin Inj Klacid 500 mg 10 ml S.W 250 ml 5%D, 5%D in 0.9, 0.45, 0.3% N.S

21 Daptomicin Inj Cubicin 350 mg N.S (0.9% w/v) only N.S (0.9% w/v) only

500 mg

22 Doripenem Inj Sudopen 250 mg 10 ml S.W, 0.9%NaCl 100 ml N.S (0.9% w/v), 5% DNot for direct injection after dilution 500 mg 10 ml S.W, 0.9%NaCl 100 ml N.S (0.9% w/v), 5% D

23 Ertapenem Inj Invanz 1 g IV 10 ml S.W, 0.9%NaCl only 50 ml N.S (0.9% w/v) only

1 g IM 3.2 ml 1%, 2% lidocaine HCl inj

24 Imipenam+Cilastatin Inj I-nem 250 mg 10 ml 0.9%NaCl 100 ml N.S (0.9% w/v), 5%,10% D

500 mg 10 ml 0.9%NaCl 100 ml N.S (0.9% w/v), 5%,10% D

25 Imipenam+Cilastatin Inj Zienam 250 mg 10 ml 0.9%NaCl, 5, 10% D 50 ml N.S (0.9% w/v), 5%,10% D

500 mg 10 ml 0.9%NaCl, 5, 10% D 100 ml N.S (0.9% w/v), 5%,10% D

26 Imipenem+Cilastatin Inj Cilanem 250 mg 10 ml S.W, N.S 0.9% 100 ml N.S (0.9% w/v), 5%,10% D

500 mg 10 ml S.W, N.S 0.9% 100 ml N.S (0.9% w/v), 5%,10% D

27 Levofloxacin Inj Levoflox Available in Diluted form Available in Diluted form

28 Linezolid Inj Linox 600 mg/300 ml dilution form 300 ml dilution form

29 Meropenem Inj Merotec 500 mg 5 ml N.S (0.9% w/v) 50-200 ml N.S (0.9% w/v)

1 g 10 ml N.S (0.9% w/v) 50-200 ml N.S (0.9% w/v)

500 mg IV bolus 10 ml S.W

1g IV bolus 20 ml S.W

30 Meropenem Inj Meroza 500 mg 10 ml S.W, N.S (0.9% w/v) 50 ml N.S (0.9% w/v)

1 g 20 ml S.W, N.S (0.9% w/v) 50 ml N.S (0.9% w/v)

31 Ofloxacin Inj Oflox 200 mg Available in Diluted form 100 ml Available in Diluted form

32 Piperacillin+Tazobactum Inj Tazact 1.125 g 5 ml S.W, N.S, 5%D 50-150 ml N.S (0.9% w/v), sterile water, 5% D

2.25 g 10 ml S.W, N.S, 5%D 50-150 ml N.S (0.9% w/v), sterile water, 5% D

4.5 g 20 ml S.W, N.S, 5%D 50-150 ml N.S (0.9% w/v), sterile water, 5% D

33 Piperacillin+Tazobactum Inj Piptamate 4.5 g Diluent in the pack (N.S 0.9%) Diluent in the pack (N.S 0.9%)

34 Polymixin B Inj Polymixin B 5 lac unit 2-3 ml 5% D 300 - 500 ml 5% D in water only

35 Teicoplanin Inj Targocid 200 mg 3 ml S.W for injection 10-20 ml 5% D, N.S (0.9% w/v)

400 mg 3 ml S.W for injection 10-20 ml 5% D, N.S (0.9% w/v)


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36 Teicoplanin Inj Ticocin 200 mg 3 ml S.W for injection 10-20 ml N.S (0.9% w/v)

400 mg 3 ml S.W for injection 10-20 ml N.S (0.9% w/v)

37 Teigecycline Inj Tevran 50 mg 5.3 ml N.S, 5%D 100 ml N.S (0.9% w/v), 5% dextrose

38 Ticarcillin+Clavulinic Acid Inj Timentin 3 g 13 ml S.W, 0.9%NaCl as per need 5% D, N.S (0.9% w/v)

for 10 mg/ml - 300 ml diluent

for 100 mg/ml - 30 ml diluent

39 Vancomycin Inj Vanlid 500 mg 10 ml S.W only 100 ml 5% D, N.S (0.9% w/v)

N.S = NORMAL SALINE

D = DEXTROSE

S.W = STERILE WATER


5/8

Duration of infusion

3-4 minutes

3-4 minutes

30-40 minutes

30-40 minutes

Over 60 minutes

20-60 minutes

over 10 minutes

over 30 minutes

30-60 minutes

20-30 minutes

over 30 minutes

over 30 minutes

15-60 minutes


6/8

over 30 minutes

over 30 minutes

over 30 minutes

over 30 minutes

15-30 minutes

15-30 minutes

30-60 minutes

30-60 minutes

30-60 minutes

30-60 minutes


7/8

over 30 minutes

Over 60 minutes

over 30 minutes

over 60 minutes

over 30 minutes

over 30 minutes

over 30 minutes

40-60 minutes

40-60 minutes

40-60 minutes

40-60 minutes

60-90 minutes

30-120 minutes

15-30 minutes

15-30 minutes

15-30 minutes

Over 60 minutes

30-60 minutes

30-60 minutes

30-60 minutes

30-60 minutes

upto 4 hours

over 30 minutes


8/8

over 30 minutes

30-60 minutes

over 30 minutes

Over 60 minutes

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Dilution of Antibiotics