Digital Health: Connecting Your Medicines to the Internet Means Better Care at Lower Cost George M. Savage, MD Cofounder & Chief Medical Officer May 2,

Digital Health: Connecting Your Medicines to the Internet Means Better Care at Lower Cost

George M. Savage, MDCofounder & Chief Medical Officer

May 2, 2013

2©2013 Proteus Confidential

6,000,000,000

87%


PersonalMedicalRecords

Percent of People with Type 2 Diabetes

<4%

4%

5%

7%

9%

>12%

Chronic Illness is an Enormous 21st Century Medical Challenge


Over 50 Percent of Prescription Medicines are Not Taken Correctly

WHO 20033

•Poor adherence to treatment of chronic diseases is a worldwide problem of striking magnitude

• Adherence to long-term therapy for chronic illnesses in developed countries averages 50%.

•The impact of poor adherence grows as the burden of chronic disease grows worldwide

•The consequences of poor adherence to long-term therapies are poor health outcomes and increased health care costs

•Improving adherence also enhances patients’ safety

•Adherence is an important modifier of health system effectiveness”

Medication adherence in heart failure1

Sources: (1) Hauptman J, Heart Fail rev 2008;13:99(2) Wong J, Can J Neurol Sci 2011; 38: 429(3) Sabate E, WHO 2003, pp xiii-xiv.

Medication adherence in multiple sclerosis2


The Patient’s View of Medical Therapy


Digital Health Feedback System: Internet-Enabled Medicines



Digital Medicines Deliver a Continuous, Unified Picture of Life

TherapeuticInformation

• Medication• Dose• Timing• Adherence• Supply Chain

PhysiologicInformation

• Heart Rate• Respiration• Activity• Posture• Gait• Sleep• Stress• Temperature

Mobile Information

• Sociability• Engagement• Cognitive Assessment• Environment• Location• Context

Subjective Information

• Side Effects• Symptoms• QOL• Mood• Emotion


Patient Engagement is the New Blockbuster “Drug”

Believe

Frame

KnowPrompt

Act

Reinforce


As With Phones, Complexity Invisible to User and Privacy Assured

Web/Mobile Applications

Patient/Caregiver Networks

Clinician and Clinical trial tools

Analytics

Patch attached to user and Paired to Phone, data upload periodic and

automatic, always on

Phone receives data from Patch, forwards to cloud. Analytics returned from

cloud

Ingestible sensor

activated upon fluid contact


$32B HF cost forecast to grow to $70B by 2030 (source: AHA)

25% of 1M discharged HF patients readmitted within 30 days

Overwhelming majority of readmissions are preventable

Solution: Digital health system to monitor medication taking and patient response

Opportunities from Heart Failure to Tuberculosis to HIV and More


• How best to regulate and reimburse cross-disciplinary digital health platform?

• How to allow business model innovation yielding improved patient care and productivity gains that lower cost?

• How to allow public and private sector payers to experiment with new, possibly transformative digital health technologies?

• How to keep platform implementation patient-centric, allowing the individual to control privacy, particularly the flow of personally-generated data?

• Blue ribbon panel• Innovators and policymakers tasked with exploring what steps are needed to

get digital health to patients

• White paper/report to Congress• Scientific innovations associated with digital health platform technologies,

challenges from regulatory and reimbursement perspectives, and potential policy solutions

Policy Considerations and Next Steps

Documents

Digital Health: Connecting Your Medicines to the Internet Means Better Care at Lower Cost George M. Savage, MD Cofounder & Chief Medical Officer May 2,