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Estadísticas de la regresiónCoeficiente d 0.98660399Coeficiente d 0.97338742R^2 ajustado 0.96451657Error típico 181.922765Observacione 5
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 3631567.87 3631567.87 109.728659 0.00185747Residuos 3 99287.6768 33095.8923Total 4 3730855.55
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 2132.01837 190.802205 11.1739713 0.00153626 1524.8006 2739.23615 1524.8006Variable X 1 120.524983 11.5058059 10.4751448 0.00185747 83.9083734 157.141592 83.9083734
Superior 95.0%2739.23615157.141592
Resumen
Estadísticas de la regresiónCoeficiente d 0.98322278Coeficiente d 0.96672703R^2 ajustado 0.96007244Error típico 135.627682Observacione 7
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 2672261.66 2672261.66 145.27213 6.93968E-05Residuos 5 91974.3404 18394.8681Total 6 2764236
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 690.987732 108.098402 6.39221042 0.00138809 413.111943 968.863522 413.111943Variable X 1 55.3762564 4.59443849 12.0528889 6.93968E-05 43.5658763 67.1866365 43.5658763
Superior 95.0%968.86352267.1866365
Resumen
Estadísticas de la regresiónCoeficiente d 0.99081063Coeficiente d 0.9817057R^2 ajustado 0.97804684Error típico 89.4093613Observacione 7
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 2144872.62 2144872.62 268.309172 1.54713E-05Residuos 5 39970.1694 7994.03389Total 6 2184842.79
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 2250.11133 71.2613308 31.5754885 5.98271E-07 2066.92825 2433.29442 2066.92825Variable X 1 49.6117852 3.02877558 16.3801457 1.54713E-05 41.8260697 57.3975007 41.8260697
Superior 95.0%2433.2944257.3975007
Resumen
Estadísticas de la regresiónCoeficiente d 0.98728965Coeficiente d 0.97474085R^2 ajustado 0.96968902Error típico 151.582508Observacione 7
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 4433416.88 4433416.88 192.94805 3.47444E-05Residuos 5 114886.284 22977.2568Total 6 4548303.16
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 1390.78728 120.814768 11.5117324 8.67188E-05 1080.22303 1701.35153 1080.22303Variable X 1 71.3269063 5.1349142 13.8905741 3.47444E-05 58.1271892 84.5266235 58.1271892
Superior 95.0%1701.3515384.5266235
Resumen
Estadísticas de la regresiónCoeficiente d 0.98806859Coeficiente d 0.97627955R^2 ajustado 0.96837273Error típico 151.226954Observacione 5
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 2823779.93 2823779.93 123.473124 0.00156168Residuos 3 68608.7753 22869.5918Total 4 2892388.71
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 1542.96333 202.89225 7.60484115 0.00471852 897.269642 2188.65703 897.269642Variable X 1 106.278501 9.56443239 11.1118461 0.00156168 75.8402083 136.716793 75.8402083
Superior 95.0%2188.65703136.716793
Resumen
Estadísticas de la regresiónCoeficiente d 0.99911685Coeficiente d 0.99823449R^2 ajustado 0.99788138Error típico 45.6434731Observacione 7
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 5889645.28 5889645.28 2827.03882 4.44969E-08Residuos 5 10416.6332 2083.32664Total 6 5900061.91
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 1396.35945 36.3789047 38.3837683 2.26158E-07 1302.8445 1489.8744 1302.8445Variable X 1 82.2107617 1.54618974 53.1699052 4.44969E-08 78.2361544 86.1853689 78.2361544
Superior 95.0%1489.8744
86.1853689
Resumen
Estadísticas de la regresiónCoeficiente d 0.97025596Coeficiente d 0.94139663R^2 ajustado 0.9316294Error típico 151.343442Observacione 8
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 2207641.23 2207641.23 96.3831874 6.43281E-05Residuos 6 137429.024 22904.8374Total 7 2345070.26
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 2613.1041 115.445522 22.6349542 4.868E-07 2330.61909 2895.58912 2330.61909Variable X 1 32.1374332 3.27348643 9.81749395 6.43281E-05 24.1275004 40.1473659 24.1275004
Superior 95.0%2895.5891240.1473659
Resumen
Estadísticas de la regresiónCoeficiente d 0.99251167Coeficiente d 0.98507942R^2 ajustado 0.98321435Error típico 141.23158Observacione 10
ANÁLISIS DE VARIANZAGrados de libertadSuma de cuadradosPromedio de los cuadradosF Valor crítico de F
Regresión 1 10535111.8 10535111.8 528.172164 1.36336E-08Residuos 8 159570.875 19946.3593Total 9 10694682.6
Coeficientes Error típico Estadístico t Probabilidad Inferior 95% Superior 95%Inferior 95.0%Intercepción 1002.09954 82.9460582 12.0813402 2.03626E-06 810.825591 1193.3735 810.825591Variable X 1 49.4259493 2.15063775 22.9819965 1.36336E-08 44.4665698 54.3853289 44.4665698
Superior 95.0%1193.3735
54.3853289
Tiempo (minutos) Absorbancia m (cantidad en mcg) C (concentracion mmol/ml)
55 0.9721 2608.01210508242 0.0177257222626183
10 1.2443 3338.28768887363 0.02268914330971715 1.5422 4137.51287774725 0.028121190076545520 1.7335 4650.74476304945 0.031609443002004725 1.8506 4964.90813873626 0.033744698713302530 1.8877 5064.44239354396 0.034421197320383240 1.9338 5188.12242445055 0.035261806101688350 1.9286 5174.17153159341 0.035166986889914260 1.9063 5114.34366414835 0.034760358347113770 1.9087 5120.78253777473 0.034804121060240280 1.9136 5133.92857142857 0.034893469932873590 1.8534 4972.42015796703 0.0337957552119501
100 1.848 4957.93269230769 0.0336972891074154
Equipo 1 acetaminofen 750 mcg/ml
tiempo absorbancia m (cantidad en mcg) C (concentracion mmol/ml)
5 0.1983 789.938159216474 0.0053689261593640710 0.3184 1268.3626318433 0.0086206055932502215 0.3948 1572.70592667002 0.010689117739369320 0.4722 1881.03277247614 0.012784704651798925 0.5567 2217.64283023606 0.015072522405032730 0.602 2398.09768960321 0.016299009318896540 0.6875 2738.69129834254 0.018613901838440750 0.7498 2986.86652435962 0.020300659779582360 0.7746 3085.65858864892 0.020972113984081770 0.7954 3168.51644902059 0.021535269123339380 0.8219 3274.08054997489 0.022252750430566490 0.8129 3238.22859116022 0.0220090775337723
100 0.8023 3196.0029507785 0.0217220850108814110 0.7945 3164.93125313913 0.0215109018336599
equipo 6 metoprolol 1250 mcg/mltiempo abs m (masa mcg) C (concentracion mmol/ml)
5 0.1904 1812.5241707571 0.0067792379331439610 0.2301 2190.45069165551 0.0081927660105904815 0.2741 2609.31131935148 0.0097593966253926520 0.318 3027.21999107541 0.011322466716070325 0.3704 3526.04492042243 0.013188181357334730 0.4091 3894.45188160048 0.014566104193535740 0.4869 4635.07362784471 0.017336191962435950 0.4884 4649.35296742526 0.017389599824304260 0.5272 5018.71188457534 0.0187710831846297
70 0.5613 5343.32887103972 0.019985221911101480 0.5735 5459.46749962814 0.020419605854296690 0.5719 5444.23620407556 0.0203626374683037
100 0.5836 5555.61505280381 0.0207792187908761110 0.586 5578.46199613268 0.0208646713698653
Gradiente de concentracion P*A
0.0417448867373818 2887.179538591780.036781465690283 3276.78575519193
0.0313494189234545 3844.568319536780.0278611659979953 4325.913094867320.0257259102866975 4684.964748995560.0250494116796168 4811.489561931440.0242088028983117 4978.560209493270.0243036221100858 4959.136637455490.0247102506528863 4877.529755649070.0246664879397598 4886.183356274490.0245771390671265 4903.946814143630.0256748537880499 4694.281175813240.0257733198925846 4676.34683196855
Gradiente de concentracion (mmol/ P*A
0.0201184778406359 2752.504460757430.0168667984067498 3283.148269433250.0147982862606307 3742.068441216920.0127026993482012 4359.404129945180.0104148815949673 5317.02636223524
0.00918839468110354 6026.754609690890.00687350216155928 8056.475243391460.00518674422041766 10676.48560382270.00451529001591828 12264.15131802740.00395213487666073 14011.7181544140.00323465356943356 17119.66948278090.00347832646622769 15920.35725733830.00376531898911856 14706.9080096620.00397650216634014 13925.8568670583
Gradiente de concentracion P*A0.016597132066856 4953.31129230878
0.0151836039894095 5414.44322072940.0136169733746074 6037.374049655050.0120539032839297 6820.260603575750.0101881886426653 8069.22256449221
0.00881026580646431 9331.246467771510.0060401780375641 13610.652066119
0.00598677017569584 13732.0724320510.00460528681537029 17851.3879770348
0 10 20 30 40 50 60 70 80 90 100 1100
1000
2000
3000
4000
5000
6000
Tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
500
1000
1500
2000
2500
3000
3500
Tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0.0033911480888986 24242.75187386440.00295676414570345 27804.30147130970.00301373253169626 27278.71860626810.00259715120912386 31654.20688556360.00251169863013465 32731.1408703085
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
Equipo 2 acetaminofen 1000 mcg/ml
tiempo abs m (cantidad C (concentra5 0.6008 2365.35433 0.01607646
10 0.7038 2770.86614 0.0188325815 0.791 3114.17323 0.0211659220 0.8405 3309.05512 0.0224904625 0.8806 3466.92913 0.0235634730 0.9478 3731.49606 0.0253616440 1.0634 4186.61417 0.0284549150 1.069 4208.66142 0.0286047660 1.1326 4459.05512 0.030306670 1.1383 4481.49606 0.0304591280 1.1933 4698.0315 0.0319308390 1.1324 4458.26772 0.03030125
100 1.133 4460.62992 0.0303173110 1.136 4472.44094 0.03039758120 1.1029 4342.12598 0.02951187
Equipo 3 1250 mcg/ml
tiempo abs m (cabntidadC (concentra5 0.3828 1545.94595 0.01050724
10 0.521 2104.06959 0.0143006115 0.6339 2560.01864 0.0173995320 0.725 2927.92793 0.0199000825 0.8141 3287.76017 0.0223457330 0.8903 3595.4955 0.0244372940 1.0045 4056.69463 0.027571950 1.0794 4359.17987 0.0296277860 1.1086 4477.10469 0.0304292770 1.1287 4558.27897 0.0309809980 1.1204 4524.75924 0.0307531690 1.0993 4439.54644 0.030174
100 1.1019 4450.0466 0.03024537110 1.0922 4410.87294 0.02997912
Equipo 7 piroxicam 1250 mcg/mltiempo Abs m (masa mcgC (concentra
5 0.4424 2058.41088 0.0062123810 0.5804 2700.50107 0.0081502415 0.6565 3054.58125 0.0092188720 0.7147 3325.37581 0.0100361425 0.7624 3547.31568 0.0107059730 0.7958 3702.72011 0.0111749940 0.8654 4026.55691 0.0121523450 0.9036 4204.29492 0.01268876
0 10 20 30 40 50 60 70 80 90 100 1100
1000
2000
3000
4000
5000
6000
Tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
500
1000
1500
2000
2500
3000
3500
Tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
60 0.9409 4377.84538 0.0132125570 0.9676 4502.07588 0.0135874880 0.9936 4623.04939 0.0139525890 0.9968 4637.93844 0.01399752
100 1.0049 4675.62634 0.01411126110 1.0175 4734.25197 0.0142882120 1.0194 4743.09234 0.01431488130 0.9972 4639.79957 0.01400314
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
Gradiente deP*A0.01790674 2770.564810.01515062 3274.570790.01281729 3870.693090.01149274 4316.791620.01041973 4761.330270.00862157 5754.382450.00552829 8974.163050.00537844 9224.189510.00367661 13493.90230.00352408 14077.92090.00205237 24172.91230.00368196 13474.289
0.0036659 13533.30050.00358563 13836.28490.00447133 11095.5244
Gradiente deP*A0.03197177 2230.93419
0.0281784 2531.261740.02507948 2844.034710.02257893 3159.002840.02013328 3542.736510.01804171 3953.444120.01490711 4784.757950.01285122 5550.202930.01204973 5919.376870.01149802 6203.407840.01172584 6082.88174
0.012305 5796.578110.01223364 5830.392860.01249989 5706.20469
Gradiente deP*A0.01265042 2540.424950.01071256 2999.977710.00964393 3332.401330.00882666 3640.95250.00815683 3939.941380.00768781 4180.309330.00671046 4789.156960.00617404 5205.2557
0 10 20 30 40 50 60 70 80 90 100 110 120 1300
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
tiempo (minutos)m
(mas
a en
micr
ogra
mos
)
0 10 20 30 40 50 60 70 80 90 100 110 1200
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
en m
cg)
0 10 20 30 40 50 60 70 80 90 100 110 120 130 1400
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
0.00565025 5687.787770.00527532 6092.036870.00491021 6545.016320.00486528 6605.466290.00475153 6763.59025
0.0045746 7025.19030.00454792 7066.404040.00485966 6613.10114
0 10 20 30 40 50 60 70 80 90 100 110 120 130 1400
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
Equipo 4 acetaminofen 1500 mcg/ml
tiempo abs m (cantidad C (concentra Gradiente de5 0.5605 2262.06044 0.01537441 0.0356004
10 0.6202 2502.99712 0.01701197 0.0339628315 0.7751 3128.14103 0.02126085 0.0297139620 0.9611 3878.79802 0.0263628 0.0246120125 1.045 4217.40083 0.02866416 0.0223106530 1.1436 4615.32975 0.03136874 0.0196060740 1.2695 5123.43574 0.03482215 0.0161526550 1.3828 5580.69078 0.03792995 0.0130448660 1.4563 5877.32136 0.03994604 0.0110287670 1.5094 6091.62182 0.04140257 0.0095722480 1.5168 6121.48667 0.04160555 0.0093692690 1.532 6182.83068 0.04202248 0.00895233
100 1.5268 6161.84458 0.04187985 0.00909496110 1.5174 6123.90815 0.04162201 0.0093528
Equipo 8 ac nalidixico 1250 mcg/mlTiempo Abs m (masa mcgC (concentra Gradiente de
5 0.425 1042.4843 0.00448892 0.0224234710 0.5697 1397.41954 0.00601727 0.0208951315 0.7232 1773.94035 0.00763856 0.0192738420 0.832 2040.81633 0.00878772 0.0181246725 0.9564 2345.95761 0.01010165 0.0168107430 1.0543 2586.09694 0.01113569 0.015776740 1.2728 3122.05651 0.01344352 0.0134688750 1.4564 3572.40973 0.01538274 0.01152966
0 10 20 30 40 50 60 70 80 90 100 110 120 1300
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
en m
cg)
0 10 20 30 40 50 60 70 80 90 100 110 120 130 1400
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
60 1.6177 3968.06319 0.01708641 0.0098259870 1.7266 4235.18446 0.01823663 0.0086757680 1.8086 4436.32261 0.01910273 0.0078096690 1.8819 4616.12049 0.01987694 0.00703546
100 1.9437 4767.70997 0.02052968 0.00638272110 2.0096 4929.35636 0.02122573 0.00568667120 2.0263 4970.31986 0.02140211 0.00551028
0 10 20 30 40 50 60 70 80 90 100 110 120 130 1400
500100015002000250030003500400045005000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
P*A2985.318023129.258833576.71999
4318.15614763.577455420.694246579.630838147.15803
9636.483311102.781911343.318411871.606411685.4256
11363.279
P*A2204.205692365.429252564.406352726.99809
2940.14123132.843783669.643034286.85309
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
7000
Tiempo (minutos)
m (m
asa
en m
icrog
ram
os)
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
5030.128875697.015996328.819297025.265027743.718498691.547468969.77032
0 10 20 30 40 50 60 70 80 90 100 110 1200
1000
2000
3000
4000
5000
6000
Tiempo (minutos)
m (m
asa
micr
ogra
mos
)
