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8/6/2019 Diagnostic and Classification of Early Stages of Perthes Disease. Nuno Craveiro Lopes; Carolina Escalda and Carlo
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Diagnostic and Classification of the Early Stages of Legg-Calv-Perthes Diseases.
Role of Ultrasonography and Magnetic Resonance Imaging.Nuno Craveiro Lopes; Carolina Escalda and Carlo Villacreses.
Orthopedic and Traumatologic Department, Pediatric Orthopedic Unit,
Garcia de Orta Hospital, Almada, Portugal
The multifactorial origin of Legg-Calv-Perthes disease (LCPD) is well documented. The same is true
for the existence of two or more ischemic episodes preceding the onset of the disease. After more than 30years of experimental and clinical data analysis about the initial stage of LCPD, the senior Author (NCL)
verified that these episodes are symptomatic. Patients complain of pain and transient limping, and it is
possible to detect those ischemic episodes with imaging techniques. The same Author has also found that
those episodes represent an autonomous disease, which, if some enchained factors are present, can evolve to
LCPD. The Author named this pre-LCPD situation, Ischemic Disease of the Growing Hip (IDGH).
To identify these ischemic episodes and to detect the cases of IDGH at risk of evolution to LCPD, the
Authors have developed a screening protocol. All pediatricians and general doctors of the area of influence
of their hospital have been informed of the protocol and advised to send all children who presented hip,
thigh or knee pain and limping for more than one day of evolution to the emergency unit. From January
1993 to December 1995, the Authors have observed 123 children, with ages between 3 and 12 years,presenting a painful syndrome of the hip. After standard clinical, radiological and laboratorial examination,
32 cases (26%) had a diagnosis, including epiphisiolysis (3), septic arthritis (3), rheuma (3) trauma (2)
LCPD (18) and other causes (3). The protocol was used on the remaining 91 cases and included a first
ultrasound screen to determine the existence of criteria of probability of IDGH. This screen have discarded
48 of the cases (53%), diagnosed as hip toxic synovitis. A second screening was made in the remaining 43
cases that presented ultrasound criteria of IDGH, using a nuclear magnetic resonance. This screening,
detected an ischemic episode in evolution in 6 of those cases (5% of all cases).
IDGH Stage I
Irregular contour
Synovitis, thick cart.
No actual ischemia
IDGH Stage II
Irregular contour
Synovitis, effusionSubchond. ischemia
IDGH Stage III
Porosis (weakening)
+ Synovitis, effusion+ Subchond. ischemia
LCPD Stage I
Dense, subchond. Fr.
+ Synovitis, effusionExtensive necrosis
8/6/2019 Diagnostic and Classification of Early Stages of Perthes Disease. Nuno Craveiro Lopes; Carolina Escalda and Carlo
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The analysis of the data of this screening protocol and of the demography of the area of influence of our
hospital, have shown the existence of a prevalence of 8,5 for LCPD and of 2,8 for active IDGH, for 100.000
children with less than 16 years and per year.
As a guide of the probability of evolution to LCPD, the Authors had developed a classification of IDGH
considering 3 stages: Stage I, represents a hip where one can identify sequel of an old ischemic episode; ithas a low probability of evolution to LCPD. Stage II, shows sequel of an old episode with a new ischemic
episode in evolution; it is considered to have a moderate probability of evolution. Finally, stage III,presenting signs of a recent episode with a new one in evolution, situation that is considered to have almost
100% of probability to evolve to Legg-Calv-Perthes disease.
From the whole of the patients diagnosed as having IDGH, 20 have not been treated and were followed.
From 15 IDGH stage II cases, 3 had evolved to LCPD and from 5 IDGH stage III cases all had evolved to
LCPD.
04/1995 - IDGH Stage III
Porosis, wider medial space
04/1995 - IDGH Stage III
Sub-chondral ischemia
10/1995 Lost from follow-up
6 months later - LCPD Stage I10/1995 LCPD Stage I
Extensive necrosis
The Authors conclude that it is possible to identify the fractional and transitory ischemic events that
precede the beginning of Legg-Calv-Perthes disease, and to define a group of cases at risk of evolution
to LCPD. This allows the introduction of measures to treat IDGH and maybe capable to prevent or to
abort the evolution to Legg-Calv-Perthes disease.