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DIABETES IN PREGNANCYDIABETES IN PREGNANCY
Josephine Carlos-Raboca, MD
• Pregnancy is a time when Pregnancy is a time when serial metabolic changes serial metabolic changes in the mother are carefully in the mother are carefully regulated to provide regulated to provide optimum substrate to optimum substrate to mother and fetus. mother and fetus.
GOALS:GOALS:
Normal outcome of index pregnancy.Decrease risk for abnormal glucose and
insulin homeostasis.Mother (before, during, after pregnancy).Infant subsequent generations.
Gestational Diabetes Mellitus Gestational Diabetes Mellitus (GDM)(GDM)
Any degree of glucose in tolerance with onset or first recognition during pregnancy.
4th International Workshop-Conference on GDM, 1998.
Pregestational Diabetes MellitusPregestational Diabetes Mellitus
Diabetes diagnosed before pregnancy.
PrevalencePrevalence of GDMof GDM
1 – 14%USA--- 3-5%MMC (Asian Population)
– Raboca et al 13.4%
Perinatal Complications:Perinatal Complications:
MacrosomiaRespiratory Distress Syndrome (RDS)HypocalcemiaHyperbilirubinemiaHypoglycemiaPolycythemia
Congenital MalformationsCongenital Malformations
SkeletalCardiac (septal and outflow tract lesions)CNS and neural tube defectsGastrointestinal DefectsGenitourinary Tract lesions
Maternal and Fetal Factors of Maternal and Fetal Factors of TeratogenesisTeratogenesis
Genetic Background Teratological Period Disturbances in Maternal-Fetal Transport Concentrations of Metabolites Hyperglycemia Hyperketonemia Somatomedin inhibitors Arachidonic/myoinositol deficiency Generation of free oxygen radicals Genotoxity
Teratology 1997
Objectives:Objectives:
1. Recognize GDM
2. Know how to provide nutritional plan
3. Know how to give insulin
4. Discuss preconception and postpartum care
5. Recognize special problems of pregestational diabetes
Case ICase I
31 year old female
G1 PO, Age of Gestation 20 weeks
Weight gain of 5 kg in the last 4 weeks
BMI (pre-pregnant) = 30 Height: 165 cm actual body weight 90 kg Family History (+) DM in mother
• Would you recommend Would you recommend testing for GDM at this testing for GDM at this time time or later at 24or later at 24thth to 28 to 28thth weeks of gestationweeks of gestation
Risk Factors of GDMRisk Factors of GDM
Age > 25 years of ageObesity – BMI > 27 kg/m2 or > 20% over
DBWFamily History of diabetes in first degree
relativeEthnicity (Hispanic American, Native
American, Asian American, Pacific Islander)
ADA 2001ADA 2001
– Low risk – no test– Average risk – test at 24th-28th
week– High risk – test at 1st visit if
negative repeat at 24 – 28 weeks.
ASGODIP– Test at 1st visit and every
trimester if negative in previous test
50 gm glucose challenge test was 150 mg/dl
100 gm OGTT F=102; 1H=192; 2H=155; 3H=140
Does this patient have GDM?
Diagnosis of GDMDiagnosis of GDM
100 gm OGTT 75 gm OGTT
mg/dl mml/L mg/dl mml/LF 95 5.3 95 5.3
1H 180 10.0 180 10.0
2H 155 8.6 155 8.6
3H 140 7.8
> 2 values met = GDM
ASGODIP, WHOEuropean Diabetes
Policy Group 1992-1998 75 gm OGTT, 2H >140
Prescribe diet for this patientPrescribe diet for this patientFor normal weight – 30 kcal/kg of
Present BWFor overweight – 24 kcal/kg of Present
BW For morbidly obese – 12 kcal/kg
Present BW3 meals, 3 snacks, 40% of total calories
= CHO Medical Management of Pregnancy
Complicated by Diabetes
1. With diet, preprandial capillary blood glucose level were 70 - 80 mg/dl,2HPPCBG 95 – 115 mg/dl
2. Would she require insulin?
ADA 2001ADA 2001
Insulin Required if diet fails to maintain glucose
at following levels. Fasting whole blood glucose < 95 mg/dl (5.3 mml/L) Fasting Plasma Glucose < 105 mg/dl (5.8 mml/L)
OR 1H Postprendial whole blood glucose < 140 mg/dl (7.8 mml/L) 1H Postprendial Plasma Glucose < 155 mg/dl (8.6 mml/L)
OR 2H Postprandial whole blood glucose < 120 mg/dl (6.7 mml/L) 2H Postprandial Plasma Glucose < 130mg/dl (7.2 mml/L)
1. How would you follow up this patient Postpartum?
2. What are her chances of developing diabetes?
75 gm OGTT > 6 wks. postpartum
FPG every year x 3 years
50% in 20 years time50% in 20 years timePredictors of DMPredictors of DM
maternal obesity fasting hyperglycemia duration of time from
index pregnancy
TRIPODTRIPOD
Case 2Case 2 28 years old Go Po
diabetic X 1 year
desires pregnancy
When is the best time for
patient to get pregnant? What advise would you
give her?
Counseling about risk of malformation with poor control
Use of low dose estrogen progestogen
contraceptive till good metabolic control is
achieved.
Goals:
HBA is 1% above normal Preprandial CBG 70-110 mg/dl (3.9-5.6mml/L)
CPG 80-110 mg/dl (4.4-6.1 mml/L) 2H Postprandial CBG < 140 mg/dl (7.8mml/L)
CPG < 155 mg/dl (8.6mml/L)
4-7 X / day4-7 X / day preprandial preprandial 1 hour or 2 hour post prandial 1 hour or 2 hour post prandial
What other medical What other medical problems should you problems should you consider in a diabetic consider in a diabetic pregnant?pregnant?
Acceleration of retinopathy Pregnancy induced hypertension Progression of Nephropathy
What is your goal for glycemic What is your goal for glycemic control during labor?control during labor?
120 mg/dl D5 0.45 NSS at 100-125 ml/hour CBG every 1-4 hours Insulin infusion to start at
1unit/hour of regular insulin if CBG > 120 mg/dl
THANK YOU.THANK YOU.
HYPERGLYCEMIA AND HYPERGLYCEMIA AND ADVERSE PREGNANCY ADVERSE PREGNANCY
OUTCOME STUDY (HAPO)OUTCOME STUDY (HAPO)
Background: Overt diabetes clearly increases the risk of adverse pregnancy outcome
What level of glucose intolerance short of diabetes increases the risk of adverse pregnancy outcome?
Study protocolStudy protocol
75gm OGTT 24-32 weeks (average 28) 0,1,2 hours
Venous plasma, enzymatic methodResults provided if FPG> 105 (5.8)
2 hour > 200 (11.1)
any value <45(2.5)
otherwise blinded to caregivers
EndpointsEndpoints
Relationship between maternal hyperglycemia and
cesarian rate
macrosomia rate
fetal hyperinsulinemia
neonatal obesity (skinfold thickness)
neonatal hypoglycemia rate
other morbidities
Study ProtocolStudy Protocol
Routine prenatal care Daily kick count from 28 weeks Random venous plasma glucose at 34-37 weeks if
> 160 mg/dl (8.9) or <45 Umbilical cord glucose and C-peptide levels Routine neonatal care Neonatal blood glucose at 1-2 hours of age First feeding 2 hours after birth (may nurse earlier
if desired)
Interim Study ReportInterim Study Report
Enrollment: 9396 womenDeliveries:5282
primary CS 14.5%
repeat CS 7.3%
prenatal loss 5.5/1000Number of OGTT: 7160Unblinded: 158 (2.2%)
Interim…Interim…
Glucose levels
FPG 10% > 90
1 hour 15% > 160
2 hour 4% > 140
SummarySummary
Preliminary data from HAPO enrollees confirm the safety of the study protocol and yielded the predicted prevalence of “lesser degrees”of glucose intolerance that should permit an adequate test of the study hypothesis.
Study HypothesisStudy Hypothesis
Hyperglycemia in pregnancy less severe than overt diabetes is associated with increased risk of adverse maternal fetal and neonatal outcomes that is independently related to the degree of metabolic disturbance.