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Development of Harvard Catalyst Imaging Consultation Service. C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD. February 27,2009. Agenda. Harvard Catalyst Imaging Consortium Technology and Expertise IT Structure Why be a consultant ? Educational Opportunities Contact. - PowerPoint PPT Presentation
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Development of Harvard Catalyst Imaging Consultation Service
C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD
http://catalyst.harvard.edu February 27,2009
Agenda
2
• Harvard Catalyst
• Imaging Consortium
• Technology and Expertise
• IT Structure
• Why be a consultant ?
• Educational Opportunities
• Contact
Harvard Catalyst: The History and the Basics
3
• GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued– BWH/MGH imaging cores (CT/AVD/GS)
• CTSA 2007(Roadmap initiative-EAZ)• HU- Response-Harvard Catalyst
– (PI Lee Nadler/Co-Director: Steve Freedman)
• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers
National Effort in C/T Research
38 AHC/23 states
4
• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08
Source: http://www.ctsaweb.org/
Duke
Mayo Clinic
Cornell
J.Hopkins
UC Davis
Wash. U.
Northwestern
Emory U.
• Imaging programs-(Dan Sullivan/RSNA)
Institutions participating in Harvard
CTSC
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Academic Healthcare Centers• Beth Israel-Deaconess Medical Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston
Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear Infirmary• McLean Hospital• Schepens Eye Research Institute
Massachusetts Institutes of Technology
Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering
Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory
Care and Prevention at Harvard Pilgrim Healthcare
Red –Imaging Consortium
Year 01 total budget: $22,148,106
Harvard catalyst
• Programs (Selected list)
– Biomedical Informatics-Kohane– Community engagement– Design and Biostats– Dev of Novel CT methodologies-Vikas– Diversity/Health Disparities research– Ethics– Linkages-HL, HBS, Kennedy School etc– Pilot studies– Regulatory-BB– Research Education
6
Harvard catalyst
• Programs– Translational Technologies and Resources-
GW• Imaging
– increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.
7
Pilot funds
• Eligibility:Any individual with a Harvard faculty appointment regardless of degree.
• Funds:Pilot grants ranging from $40,000 to $100,000 for one year. Majority of the awards will be in the $50,000 to $75,000 range. Application for second year of funding will be considered if benchmarks are achieved. Occasionally grants up to $200,000 will be awarded.
• Deadlines:RFA Posted for Round One - September 4, 2008 Preliminary Proposal (two page) Due - October 15, 2008Semi-Finalists Selected - November 7, 2008Secondary Application (5 pages) Due - December 7, 2008Round One Pilots Grants Funded - January 15, 2009
• Contact:Harvard Catalyst Research NavigatorsE-mail617 432-7800
8
Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director
Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director
Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager
Valerie Humblet, Imaging Liaison
Imaging Consortium Team
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Mission of the Imaging Consortium
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• Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research
• Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment.
Harvard Catalyst website
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• Access to resources and profiles
http://catalyst.harvard.edu/home.html
Image Consortium Consultation Service
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• Access to the consultation service:
http://catalyst.harvard.edu/home.html
Technologies and Expertise
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• Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging.
• Focused on assisting with planning and design of research proposals and/or methods for image analysis.
• Consultation is available for the preparation of a grant or IRB submission.
• We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies.
XNAT-PACS-i2b2 Integration
14
• IT Catalyst infrastructure:– i2b2: scalable computational framework to help
translation of genomic findings. – BIRN: XNAT imaging informatics platform: large
collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer.
XNATEnterprise
DataRepository
(CRC)
FileRepository
IdentityManagement
OntologyManagement
CorrelationAnalysis
De -Identification
Of dataNatural
LanguageProcessing
AnnotatingGenomicData #1
ProjectManagement
WorkflowFramework
AnnotatingGenomicData #2PACS PACS
i2b2 HIVE
Dr X Desktop Pediatric
rare disease
Dr YDesktop
Alzheimer
Dr ZDesktop
Chronic pain management Dr W
Desktop Quantitative
cancer biomarkers
XNAT-PACS-i2b2 Integration
15
Slicer:Data
visualization analysis
Becoming an Imaging Consultant
16
• Potential benefits of being an active collaborator:– Good framework for research– Research opportunities through collaborations– Meeting experts out of radiology– Networking with imaging cores outside of Boston
• Example: standardization of physiologic monitoring system for fMRI
Educational Opportunities proposal
17
• Nanocourse: Imaging 101• More advanced classes:
– Tumor metrics– Radiation safety issues for IRB submission– Hands-on classes on data analysis– Imaging perfusion– Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt