Development of a Wearable, Wireless, NIR* Imaging Device

Rowan University Biosensors LabLinda M. Head PhD, Faculty Director

Rane Pierson BSECE, MS Student Undergraduate Students:

Jessica Donovan, Andrew Flanyak, Michael McDonald

*Near InfraRed

OUTLINE

A. Uses of fNIRB. Our goalsC. Progress to dateD. Future workE. AcknowledgementsF. References

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APPLICATIONS OF NIR SENSING & IMAGING TECHNIQUES

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Figure 1: Hb and HbO2

absorption spectra [1]

1. Absorption of radiation by Hb and HbO2 exceeds absorption by H2O at NIR wavelengths. [1]

2. Medical applications for near-infrared have proliferated into areas of blood analyte monitoring and imaging of materials including tissue. [2,3]

3. Specific applications include:a) Oximetry – measurement of O2 levels in the

blood (e.g. pulse oximetry) [4]b) Non-invasive assessment of brain function [5]c) In-vivo muscle metabolism measurement [6]

GOALS FOR ROWAN NIR IMAGING PROJECT

Integrated electronicsCustom packageReconfigurable FPGA-based control and data

processingWireless portability

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Figure 2: Modular Concept Drawing

Fully modular and programmable NIR sensor.

STATE OF THE PROJECT: INTEGRATED ELECTRONICS

• Prototype component-based version of control system completed.– λ designation– Sampling rate– Noise suppression– Data storage &

transmission

• Spartan3 development board prototype.

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Figure 3: Component-Based Board layout

STATE OF THE PROJECT:SENSOR

• NIR LED with 4 programmable settings:– dark – 730 nm – 805 nm – 850 nm

• OPT101 Photodiode detector• Customizable package with embedded flexible circuit• http://www.youtube.com/watch?v=j5SYnL0bh50

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Figure 5: Version1, Molded Rubber Sensor Assembly

Figure 4: EPITEX NIR LED Specifications

STATE OF THE PROJECT:WIRELESS SOLUTION

• Goal is a single chip solution that can be embedded in the individual sensor modules– Single unit/multiple sensor – custom design– Multiple unit/multiple sensor – modular design

• Wireless network solutions required

• Development board in use for design prototypes

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Figure 6: Radiotronix RK-Wi232-DTS-R [7]

FUTURE PLANS

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Jr/Sr “Clinic” Thesis Project

Product Development

Sensor Package

Wireless Network

Project Planning

FPGA SolutionsPhantom Production

Prototype ProductionTesting/Verification

Funding Proposals

Data Analysis Solution Conference Presentations

ACKNOWLEDGEMENTS

• Initial project conceived in collaboration with the Functional Optical Brain Imaging group at Drexel University.

• Funding provided by Rowan Dean’s Research Fund, Electrical & Computer Engineering program.

• Dr Sachin Shetty for conversations on wireless networks.

• Drs. Ramachandran and Tang for allowing undergraduates to miss class today!

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REFERENCES1. http://www.biop.dk/Research/Main_research_tweezers.htm2. http://www.spectroscopynow.com/coi/cda/detail.cda&id=1881&type=EducationFeature&c

hId=2&page=1#Refs3. E. Ciurczak and J. Drennen, Near-Infrared Spectroscopy in Pharmaceutical and Medical

Applications, Marcel-Dekker, Inc. New York, 2002.4. Yoshiya I, Shimada Y, Tanaka K. Spectrophotometric monitoring of arterial oxygen in the

fingertip. Med Biol Eng Comput 1980;18:27-325. Wolf M, et al. Progress of near infrared spectroscopy and imaging instrumentation for brain

and muscle clinical applications. J. Biomed. Opt. 2007; 12, 062104. Review6. Yuanqing Lin,a) Gwen Lech, Shoko Nioka, Xavier Intes, and Britton Chance, Noninvasive,

low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager. Review of Scientific Instruments, Vol. 73, No. 8, August 2002.

7. http://www.radiotronix.com/products/proddb.asp?ProdID=12

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