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1RaLabo
Insignifi“precoIn thisgold c
Misoflurscannewere mmaps 40s). TFA = 3, 4 hosourcemetho90 mithe blinput f
ReLnCaptumorhours POST
permeeffectsFigureaccumeffectsmonitRefereal., MaFundedCytImm
DeteIsabelle I
adiology, Universoratory, Minneapo
ntroduction. Reicantly improveonditioning”, has work, we propconstruct (CYT-6
Materials & Merane in O2/N2O ed using an RF vmonitored throuprior to contrastThe same basic 30º, total acquisours after an intre DICOM viewiods using the prenutes of the expood to ve) and kfunction (AIF) wesults. In one cap tumors after inr region is showafter injection o
T, while kep dro
eability and retes were observede 1c. Along with
mulation of theras of CYT in vivor novel precond
ences. 1. Goel, R.,agn Reson Med, 20d by NIH P41 Rmune Sciences, In
ction of the efltis1, Jeunghwan City of Minnesota -
olis, MN, United StStates, 4
ecently, it has bed by using TNFs been studied uose to use Dyna6091) [1] in micethods. Four to(50/50). A cathevolume coil (Mi
ughout the expert injection (FOVacquisition was
sition time = 1h ravenous injectiong software (Ose-contrast T1 maperiment. The pakep (rate constanwas determined fase, the data wentraperitoneal inj
wn (B, average oof CYT. The parops considerably
ention (EPR) [6]d in the muscle, h improving cryapeutic agents pvo with non-desditioning of ther, et al., Mol Cance005. 5. Ocak, I., e
RR008079, The Wnc. for providing C
ffect of nanopaChoi2, Emily Colon
CMRR, Minneapotates, 3Biomedical 4Department of Ur
een shown that thF-� based nanopausing invasive oramic Contrast Ence bearing LnCapo 5 weeks after eter was placed iillipede, Agilentriment. A multisV = 35 mm, matrs used to acquire29min. Animalson of CYT (POSsiriX) [2]. Paramaps [3, 4]. The aarameters ve (exnt between the vfrom a posterior re discarded duejection of Gd (A
of 10 tumors). Inrametric maps oy after CYT, sug
]. The results ofthe greatest chan
yosurgical procedpreferentially witructive method
rapeutic intervener Ther, 2007. 2. Rt al., AJR Am J R
WM KECK FoundCYT-6091.
article preconnna1, Manda Vollmolis, MN, United SEngineering, Uni
rologic Surgery, U
he outcome of crarticles before thr post-mortem mnhanced Imagingp tumors, beforeimplantation onin the intraperitot, Palo Alto) at alice gradient echrix size = 128 xe DCE-MRI dats were scanned oST). Enhanceme
metric maps werearea under the gaxtravascular and ve and plasma) vessel within th
e to movements A). Enhancementn both the tumoof a typical mousggesting slightly
f this study demnges in contrast dures, the retentiithin a tumor, th
ds is important antions will be advRosset, A., et al., J
Roentgenol, 2007. dation and AHC
nditioning in amers1, Mithun SheStates, 2Mechanicaversity of Minneso
University of Minne
ryosurgery, a prohe procedure is
methods in animag (DCE-MRI) ase and after injectn both hindlimboneal cavity for a 9.4T magnet eqho sequence was
x 128, 1 mm thica to follow conton day 1 withou
ent curves were oe obtained by firadolinium conceextracellular vowere calculated
he imaging volumduring the acqut curves of the sir and the musclse are also showy slower “washi
monstrate that enretention are fo
ion of contrast inhus increasing eas such compounvantageous in fuJ Digit Imaging, 2189(4): p. 849. 6.
Translational Re
a mouse modelenoi3, Joel Slaton4,al Engineering, Unota - Bioheat and Mesota, Minneapolis
ocedure gainingperformed [1].
als, but has neves a method to mtion of CYT-609bs of LnCap tumGadolinium-DTquipped with a Vs acquired at muckness, TE = 1.4trast kinetics wiut injection of Cobtained in regiorst converting thentration curve (olume per unit vo
by applying theme to mitigate su
uisition. Figure 1ignal relative to le (not shown),
wn (C). In the tuin” and a substa
tumor, respecslightly increa
between PREincreased (5-fothe AUGC m250% in the tuAUGC maps processing damodeling is dsmall size of th
Discussionthe effect of construct can using DCE-MPreconditioninphysiological
nhanced EPR is ound in the tumon these studies mefficacy while rends progress towuture translationa004. 3. Daldrup, HShenoi, M.M., et esearch Grant Pro
Figure 1.injection (signal enhdynamic cvivo in tuData are mThe solid w
l of prostate c, John Bischof2, anniversity of MinnesMass Transfer Labs, MN, United Stat
g acceptance for The effect of th
er been charactermonitor in vivo th91 (CYT). mors, 6 male nuTPA (Gd) injectiVarian console. ultiple flip angle43 ms, TR = 65 th the followingYT (PRE), recoon of interests (t
he signal changes(AUGC) was deolume of tissue)e two-compartmubject and exper
1 shows an axialthe maximum swe observed th
umor region, Ktrantially slower “ctively. In the ase post-CYT. V
E and POST coold) in the area o
maps show that umor, and by onare independen
ata. This is signdifficult to identhe vessels in then and Conclus
“preconditioninbe detected non
MRI in a moung has been event involving,likely the resul
or as demonstratmay indicate theeducing toxicitywards clinical tral studies. H.E., et al., Magn al., Nanomedicineogram 2009 09-0
Axial view of a m(A). Regions of inhancement at eachcurves of relativeumors before and mean ± SEM. In Cwhite line delineat
ancer by MRInd Gregory J Metzsota - Bioheat and boratory, Minneaptes
prostate cancer this nanoparticlerized in vivo in the effect of a we
ude mice were aon (0.6 mmol/kgTemperature an
es (from 5 to 40ms, 4 averages,
g parameter chanovered, and scanntumor and muscls to concentratio
etermined by int), KTrans (transf
ment Kety modelrimental variatio view of a typic
signal observed aat contrast uptak
rans is slightly lo“washout” of thmuscle, these sVe is comparab
onditions, while of the tumor POGd concentrati
nly 18% in the mnt of the kineticnificant as the Atify reliably in
e imaging volumsion. In this wong” of the tumn-invasively in tuse model of
shown to b, among other chlt of CYT admited in the pharme potential of CYy. The ability torials. Non-invasi
Reson Med, 1998e (Lond), 2011. Ac
08. We also grate
mouse after CYT nterest for the tumoh time point is obe signal enhancem
after CYT treatmC), the parametric tes the tumor regio
I zger1 d Mass Transfer polis, MN, United
treatment, can bon the tumor, o
the intact animaell-defined TNF-
anesthetized witg). Animals wer
nd respiration rat0º) to calculate T, acquisition timnges: 8 averagesned again on dale) using an opeon using standaregrating over thfer constant froml [5]. The arteriaons. al mouse bearinafter CYT for thke is enhanced ower PRE versuhe contrast in thsame parameter
ble in the muscl
it is drasticallOST. Remarkably
ion increases bmuscle. Note thac model used foAIF used for thmice due to th
me rk, we show tha
mor by a TNF-the intact animaprostate cancerbe a complehanges, enhanceinistration. Whil
macokinetic mapsYT to enhance tho characterize thive techniques t
8. 4. Deoni, S.C., ecknowledgements
efully acknowledg
and gado-linium or are drawn and btained (B). The ment obtained in ment are shown. maps are shown.
on.
e or l. -�
h re te T1
me s, y n d e
m al
g he 4
us he rs e
y y, y at or e
he
at -� al r. x d e s, e
he o
et s.
ge
3020Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)