Urea Breath Test (UBT)

A noninvasive, nonradioactive breath test for effective, proactive H pylori management to:• Accurately detect active H pylori infection using

patient breath samples1-3

• Determine whether treatment for an H pylori infection has been successful2,3

• Provide cost-effective testing relative to other diagnostic methods2

UBT provides the ability to differentiate between active and resolved infections1,2

• Antibody testing cannot distinguish between active infection and recent exposure to infection1,2,4

• Accuracy of blood antibody tests differs based on geography and varying local H pylori strains4

• Reduces the number of patients inappropriately treated1

Accuracy, simplicity, and convenience for H pylori detection

Urea Breath Test for H pylori

“ Because of its lower specificity, serologic testing leads to more treatment of patients without active infection, more antibiotic resistance, and wasting of resources.”

— Cleveland Clinic Journal of Medicine1

UBT: Increased Predictive Values Over Antibody Testing1*

Sensitivity for Active Infection

94.7%

Urea Breath

Test

85%

Serum IgG AntibodySerology

Specificity for Active Infection

95.7%

Urea Breath

Test

79%

Serum IgG AntibodySerology

*Data are weighted mean values compiled from multiple published clinical trials.

UBT is accurate and easy to use for diagnosis and post treatment testing.

Detect with breath

QuestDiagnostics.comQuest, Quest Diagnostics, any associated logos, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third party marks - ® and ™ - are the property of their respective owners. © 2015 Quest Diagnostics Incorporated. All rights reserved. SB3440 09/2015

For further information on usage and warnings regarding the H pylori assay, see the FDA approved package insert.

References: 1. Vakil N, Fendrick AM. How to test for Helicobacter pylori in 2005. Cleve Clin J Med. 2005;72 (suppl 2): S8-S13. 2. Saad R, Chey WD. A clinician’s guide to managing Helicobacter pylori infection. Cleve Clin J Med. 2005;72(2):109-110, 112-113, 117-118. 3. BreathTek UBT Kit [package insert]. Rockville, MD: Otsuka America Pharmaceutical, Inc.; 2013. 4. Chey WD. Diagnosis of Helicobacter pylori. Pract Gastroenterol. 2001;25(4):28-41.

Get results in a few easy steps for you and your patientBaseline breath sample is collected prior to ingesting 13C-urea (a naturally occurring, nonradioactive carbon isotope) prepared in a Pranactin®-Citric solution

Second breath sample is then collected after ingestion of 13C-urea

• 13C-urea is degraded by H pylori-associated urease, producing ammonia and 13CO2

• The 13CO2 is absorbed in the blood and then exhaled in a postdose breath sample

Presence of H pylori is indicated by an increase in the ratio of 13CO2 to 12CO2 between pre- and postdose samples.

For more information about the H pylori UBT Test Collection Kit, please contact your Quest Diagnostics sales representative or visit QuestDiagnostics.com.

Collect secondbreath sample after

15 minutes. Usesame procedure asexplained in Step 1.

4

Send both breathsamples to Quest

Diagnostics.

Physician receivespatient results andtreats accordingly.

6

Patient drinksPranactin®-

Citric solution.

3

2

PreparePranactin®-

Citric solution

1

Collect baselinebreath sample.Patient takes a

breath, holds it fora count of 2, and

exhales into the bag.

5

Administration of H pylori UBT:

Exhale, drink, exhale, done...it’s that simple.

Helicobacter pylori Urea Breath – Test Code: 14839(X)