DESIGNER GENES: PLYM

A PRESENTATION BY MEGAN HINES

BRITTANY DANIEL, ACTRESS

WHAT IS NON-HODGKIN’S LYMPHOMA?• A cancer of lymph tissue

• No initial cause

• Affects those of any age but almost half that are affected are over age 65

• Symptoms- swollen lymph nodes on neck, armpits, groin; abdominal pain or swelling; chest pain, coughing or trouble breathing; fatigue, fever, night sweats, weight loss

• Treatment depends on the symptoms, stage/location of the disease, and the age/health of the patient.

HOW DOES PLYM SAVE LIVES?

• Vector: The pLym is inserted into the retrovirus (aka deadened cell).

• Den-ase: The operon will be turned on in the presence of intestinal microbiota to trigger transcription.

• GLP: Growing Lymph Protein, begins transcription in the presence of Den-ase.

• *Intestinal Microbiota – the bacteria that lives in the human gut; cancer of white blood cells

ORIpLym

Den-ase

GLP

EARLY DETECTION (THE PILL)

This pill will be taken with the bacteria in it where the GLP will glow.

LYMPHOMA AWARENESS

FDA COMPLIANCE GUIDELINES

• http://www.fda.gov/iceci/compliancemanuals/compliancepolicyguidancemanual/ucm074396.htm

WORK CITED

• "Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, 15 July 2013. Web. 24 Mar. 2014.

• "Swollen Lymph Nodes: Causes, Symptoms, and Treatment." WebMD. WebMD, 6 Dec. 2012. Web. 24 Mar. 2014.