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Cambridge Polymer Group, Inc. 56 Roland Street, Suite 310 Boston, MA 02129 Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100 ANALYZE RESEARCH CREATE Cambridge Polymer Group [email protected] www.campoly.com ISO 9001:2008 Certified Rev: Summary Data and outcomes Description Uses Design of Experiments / Formulation Development Traditional strategies for material development can be involved, requiring gradual iteration towards a target set of properties. Design of Experiments (DoE) allows a structured, statistically robust approach to material development and generates predictive tools for determining optimal formulations from a minimum of experiments. Although DoE does not replace intuition and inspiration, the careful use of the technique allows large parameter spaces to be explored in a highly efficient manner. Experience is important with DoE results. Often, there are a few more steps necessary to make the most of the DoE data because a clear understanding of the physical processes involved is critical to fully leverage the experimental results. As a project progresses, priorities can change. In this situation, the DoE data can be manipulated to address changes in customer interests or needs and can be used to predict properties that were not part of the initial requirements. Design of Experiments (DoE) is a technique for developing an experimental matrix design that requires specific inputs, measurable outcomes, weighted interests, and experience in reviewing the output. At CPG, our experience will help you plan the shortest route to improved product performance. Utilization of a well planned DoE saves supplies, energy, and time. Our experience can help you minimize necessary resources while maximizing product performance. Our broad range of backgrounds allows us to help our clients in choosing relevant parameters and decision weights. Efficient lower cost Research Development and problem solving is possible due to more information from fewer experiments, and the outcomes can be used to predict new formulations and materials. . Formulations Material optimization Property prediction 06/03/11 20.32 43.03 65.75 88.47 111.18 30.38 48.94 67.50 86.06 104.62 0 45 90 135 180 Injection force A: PVAInjection Force B: PEGMW*Conc

Design of Experiments / Formulation Development · • Create and execute experimental design • Validate and verify manufacturing processes • Perform root-cause analysis in product

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Page 1: Design of Experiments / Formulation Development · • Create and execute experimental design • Validate and verify manufacturing processes • Perform root-cause analysis in product

Cambridge Polymer Group, Inc.56 Roland Street, Suite 310Boston, MA 02129

Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100

ANALYZE ● RESEARCH ● CREATE

Cambridge Polymer Group

[email protected]

ISO 9001:2008 CertifiedRev:

Summary

Data and outcomes

Description

Uses

Design of Experiments / Formulation Development

Traditional strategies for material development can be involved, requiring gradual iteration towards atarget set of properties. Design of Experiments (DoE) allows a structured, statistically robust approachto material development and generates predictive tools for determining optimal formulations from aminimum of experiments. Although DoE does not replace intuition and inspiration, the careful use of thetechnique allows large parameter spaces to be explored in a highly efficient manner.

Experience is important with DoE results. Often,there are a few more steps necessary to makethe most of the DoE data because a clearunderstanding of the physical processes involvedis critical to fully leverage the experimentalresults. As a project progresses, priorities canchange. In this situation, the DoE data can bemanipulated to address changes in customerinterests or needs and can be used to predictproperties that were not part of the initialrequirements.

Design of Experiments (DoE) is a technique fordeveloping an experimental matrix design that requiresspecific inputs, measurable outcomes, weightedinterests, and experience in reviewing the output. AtCPG, our experience will help you plan the shortestroute to improved product performance. Utilization of awell planned DoE saves supplies, energy, and time.Our experience can help you minimize necessaryresources while maximizing product performance. Ourbroad range of backgrounds allows us to help ourclients in choosing relevant parameters and decisionweights. Efficient lower cost Research Developmentand problem solving is possible due to moreinformation from fewer experiments, and the outcomescan be used to predict new formulations and materials.

.

• Formulations

• Material optimization

• Property prediction

06/03/11

20.32

43.03

65.75

88.47

111.18

30.38

48.94

67.50

86.06

104.62

0

45

90

135

180

In

ject

ion

forc

e

A: PVA Injection Force B: PEG MW*Conc

Page 2: Design of Experiments / Formulation Development · • Create and execute experimental design • Validate and verify manufacturing processes • Perform root-cause analysis in product

Cambridge Polymer Group, Inc.56 Roland Street, Suite 310Boston, MA 02129

Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100

ANALYZE ● RESEARCH ● CREATE

Cambridge Polymer Group

[email protected]

ISO 9001:2008 CertifiedRev:

ANALYZE ● RESEARCH ● CREATE

Cambridge Polymer Group, Inc.56 Roland Street, Suite 310Boston, MA 02129

Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100Cambridge

Polymer Group ISO 9001:2008 CertifiedRev:

[email protected]

06/03/11

Cambridge Polymer Group, Inc. is a contract research laboratory specializing in materials. We partner with our clients to solve problems utilizing our multi-disciplinary

research team and full service laboratory.

We work with clients throughout the product life cycle to:• Develop new materials• Design prototypes for proof-of-concept studies• Create and execute experimental design• Validate and verify manufacturing processes• Perform root-cause analysis in product failures

Cambridge Polymer Group, Inc. was founded in 1996 to provide a cost-effective resource for testing, research and

development to clients who need periodic access to Ph.D.-level scientists and their support structure. We have developed a host of testing methods and materials for our

clients, which number more than 300.

Page 3: Design of Experiments / Formulation Development · • Create and execute experimental design • Validate and verify manufacturing processes • Perform root-cause analysis in product

Cambridge Polymer Group, Inc.56 Roland Street, Suite 310Boston, MA 02129

Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100

ANALYZE ● RESEARCH ● CREATE

Cambridge Polymer Group

[email protected]

ISO 9001:2008 CertifiedRev:

ANALYZE ● RESEARCH ● CREATE

Cambridge Polymer Group, Inc.56 Roland Street, Suite 310Boston, MA 02129

Ph: 1 (617) 629 4400 Fax: 1 (617) 629 9100Cambridge

Polymer Group ISO 9001:2008 CertifiedRev:

[email protected]

06/03/11

Cambridge Polymer Group, Inc. is a contract research laboratory specializing in materials. We partner with our clients to solve problems utilizing our multi-disciplinary

research team and full service laboratory.

We work with clients throughout the product life cycle to:• Develop new materials• Design prototypes for proof-of-concept studies• Create and execute experimental design• Validate and verify manufacturing processes• Perform root-cause analysis in product failures

Cambridge Polymer Group, Inc. was founded in 1996 to provide a cost-effective resource for testing, research and

development to clients who need periodic access to Ph.D.-level scientists and their support structure. We have developed a host of testing methods and materials for our

clients, which number more than 300.