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Neurociencia de S
istemas
Rodrigo Q
uian Quiroga
Departm
ent of Engineering
University of Leicester
ww
w.le.ac.uk/neuroengineering
“… ‘You’, your joy and your sorrow
s , your m
emories and your am
bitions, your sense of personal identity and free w
ill, are in fact no m
ore than the behaviour of a vast assembly of
nerve cells and their associated molecules.”
Francis Crick. The Astonishing hypothesis.
Francis Crick (1916-2004)
Cracking the neural code!
Main research areas
How
are concepts represented in the hum
an brain?H
ow can w
e optimise data processing m
ethods to obtain m
ore information from
neural data?
Can paralized patients m
ove prosthetic devices w
ith their thought?
I - Recordings in epileptic patients
II - Advanced processing of neural data
IV - Neuroprosthetics
III - Art &
Science
Can w
e combine know
ledge from arts and
neuroscience ?
V - EEG &
Eye tracking
How
can we study non-invasively perception
and mem
ory processes?D
o animals have conceptual
representations as humans?
VI - Anim
al recordings
Neurociencia de Sistem
as
•M
odelado
•A
nalisis de seniales
•Experim
entos (Neurofisiologia)
Which level?
Neurociencia de Sistem
as
•Clase 1. Introducción
•Clase 2. Registros extracelulares y Spike sorting.
•Clase 3. Procesado de inform
ación visual.
•Clase 4. Percepción y m
emoria.
•Clase 5. D
ecodificación – Teoría de la información.
•Clase 6. Electroencefalografía – A
nálisis de tiempo-frecuencia y W
avelets.
•Clase 7. Potenciales evocados – A
nálisis de ensayo único.
Algunas ideas basicas
de Neurociencia
Phrenology
Franz Gall
Pierre Flourens
Aggregate-field view
Brocca’s area: Speech
Wernicke’s area: Language understanding
Motor areas (Jackson)
Are functions localized?
Ram
on y Cajal
Extracellular recordings
Movem
ent planning areas
Richard A
ndersen
Monkey does reaches and saccades
Adapted from
ww
w.vis.caltech.edu
Recorded activity for an eye
movem
ent to a briefly flashed target.
FLAS
HE
D TA
RG
ET
EY
E M
OV
EM
EN
T
Tim
e
Movem
ent planning areasPlanning of arm
reaches
Planning of saccades
Spike sorting?Spike detection
Spike sorting
Wave_clus
Neural C
omputation, 2004
www.le.ac.uk/csn
Visual perception
Visual pathway
from van E
ssen and colleagues
Time
Time
Orientation TuningD
avid Hubel &
Torsten Wiesel
Kanizsa triangle
Perception
Change blindness
Visual illusion
Scintillating grid illusion
Scintillating grid illusion
Scintillating grid illusion
Perception
Hippocam
pus
V1
ITPerception Action
Hubel and W
iesel
Gross and cow
orkers
Single cell recordings in humans
•Subjects: –
Epileptic patients, candidates for epilepsy surgery
•Recordings:–
64 microwires able to record single-
neurons and LFPs•
In hippocampus, am
ygdala, entorhinal cortex and parahippocam
pal gyrus.
Clinical contacts
MR
I
Background image by Peter Clevestig. Graphic design by Dave Barton.
DecodingN
ature Review
s Neuroscience 10: 173-185; 2009
Unit 1
Unit 2
Unit 3
Unit 4
Unit 5
1sec
40 Hz
J. Neurophysiology, 2007
Neural Prosthesis
Adapted from
ww
w.vis.caltech.edu
From A
ndy Schwartz lab
Neurociencia de Sistem
as
•Clase 1. Introducción
•Clase 2. Registros extracelulares y Spike sorting.
•Clase 3. Procesado de inform
ación visual.
•Clase 4. Percepción y m
emoria.
•Clase 5. D
ecodificación – Teoría de la información.
•Clase 6. Electroencefalografía – A
nálisis de tiempo-frecuencia y W
avelets.
•Clase 7. Potenciales evocados – A
nálisis de ensayo único.
Electroencephalography (EEG)
Hans Berger (1873-1941)
Scalp EEG
Blink artifact
Sleep stages
Grand M
al Seizure
Intracranial recordings
EE
G of an epileptic patient
Seizure-w
arning devices
Evoked potentials
Time (sec)
µVµV
Time (sec)
Averaged evoked potentials
Wavelet function
--
Multiresolution decom
position
EP_den �
Nonlinear dynam
ics
Phase sp
ace
Synchronization
Lorenz driven by a Rossler
Coup
ling
Lorenz driven by a Rossler
Clase 1. Introducción a neurociencia de sistem
as
The Astonishing H
ypothesis. Francis Crick. 2004. (el m
ejor de divulgacion entre m
uchos…)
Gazzaniga, Ivry and M
angun. Cognitive N
euroscience (excelente libro de texto) K
andel, Schw
artz and Jessell. Principles of N
eural Science (caro
pero el mejor – el m
as completo)
Que es la m
emoria?
Rodrigo Q
uian Quiroga.
Paidos, 2015. (de autor controvertido, pero relativam
ente barato) B
orges y la Mem
oria.R
odrigo Quian Q
uiroga. Sudam
ericana, 2011. (del mism
o autor, que lucra con B
orges…)