Department of Chemistry Seminar Announcement

Date/Time/Venue

Title/Speaker

1 Feb (Tue)3pm – 4pm

@ S8 Level 3 Executive Classroom

New Glycosylation Protocols for New Glycosylation Protocols for the Synthesis of Complex the Synthesis of Complex Glycoconjugates of Biological Glycoconjugates of Biological SignificanceSignificance

Professor Yu BiaoProfessor Yu BiaoShanghai Institute of Organic Chemistry Chinese Academy of SciencesHost : Asst Prof Wang Jian

About the Speaker

All are Welcome

AbstractGlycoconjugates of the secondary metabolites exist abundantly in

plants, microorganisms, and lower marine animals. Many of those compounds bear complicated carbohydrate residues which occur as heterogeneous ‘glycoforms’, so that isolation of a homogeneous congener, especially in an appreciable amount, is always a formidable task. The poor accessibility remains as a hurdle for elucidation of the structure-activity relationships and the mechanism of action of glycoconjugates, which have shown a variety of the pharmacological activities. This lecture focuses on our synthetic accesses to the complex glycoconjugates of steroids and triterpenes, which are mostly from the traditional Chinese medicinal plants. Highlighted are new glycosylation methods which have been developed to tackle the emerged synthetic problems.

Professor Yu Biao received his B.S. in Nuclear chemistry from Peking University in 1989, his M.S and Ph.D (with Prof. Y.Z.Hui) from Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), in 1992 and 1995, respectively. After one-year postdoctoral research in New York University, Professor Yu returned to SIOC as an Assistant Professor, and became an Associate Professor in 1997 and Professor in 1999. His research interests include total synthesis, synthetic methodology and chemical biology of biologically significant oligosaccharides, glycoconjugates, and other natural products,especially the glycosaminoglycans of mammal, antibiotics of microbe, glycosides of plants and marine species and Chemistry in the Traditional Chinese Medicine. He received the National Award for Natural Sciences (2nd Class) in 2010.