Denis Poncelet - · PDF fileDenis Poncelet. ENITIAA, BP82225, F-44322 Nantes ... Prilling Spraying Emulsion Dispersion Stabilisation Solidification Gelification Polymerisation

ENITIAA, BP82225, F-44322 Nantes - Email : [email protected]

Microencapsulation ?Denis Poncelet


Introduction : définitions

Microencapsulation

Entrapment of a material inside microparticles for :

immobilized itprotect itrelease itstructure it

microcapsulesmicroparticlesmicrospheres

nanocapsulesnanoparticlesnanosphères

micellesliposomes

(micro)emulsions

molecular inclusion

matrixmicrocapsule

reservoir or hollowmicrocapsule

polynuclear or multicore

microcapsule

micelle

uni- or multilamellar vesicle

Hydrogel bead


Objectives : Immobilization

Continuous processing (bio-cells & enzymes)

Microencapsulation



Volatile compounds

Lactic bacteria culture

free cells< 108

cells/ml

immobilized> 1010cells/ml

http://www.mane.com/


Objectives : Protection

About degradation (O2, ligth, heat, water)

Microencapsulation



During shell-life, processing and digestion

www.customprobiotics.com

Vitamin A / monosodium glutamateappearance (white)protection (water, T, ligth)

www.encap.com

www.balchem.com

Meatshure


Objectives : Protection

Microencapsulation



Taste masking

Medium protection

Ferrous fumarate agglomerated and coated with 60% hydrogenated soy oil using the Wurster process. 100-450 µm

Immunoprotection

www.human-nutrition.basf.com

http://www.islet.com


Objectives : Release

Diffusion-rehydration-degradation-rupture

Microencapsulation



Chemical - physical - mechanical factors

www.salvona.com


Release of a by-product

Water

2 enzymesglucose+ HCN

lactoperoxidase system (LPS)

OSCN- Listeriabactericide

Objectives : Release

Microencapsulation



material immobilizationcontrol of hygroscopyflowdability & dispersibilityenzyme protectionhigh reaction efficiencycontrolled releaselong term & more efficient action against listeria


Objectives : Structuration

Liquid or gaz to solid

Microencapsulation



Dispersibility

Solubility

Flowdability

Tabletisatisable

Dust free powder

Hygroscopicity controle

Spic and Span


Objectives : Structuration

Microencapsulation



Visual aspect and marketing concept

http://www.colorcon.com

http://www.coletica.fr

http://euracli.fr/


Microencapsulation : Applications

Chemistry Printing & recording Carbonless paper Adhesives Pigments and fillers Catalysts

Agriculture Fungicide - herbicide Insect repellent Biopesticide Pigments and fillers Artificial insemination

Food & feed Aromas Probiotics Unsaturated oil Enzyme food processing aminoacid for cows

Medecine & Pharmacy & vetinary Controle release Taste masking Vectorisation Artificial organs single dose treament

Biotechnology & enviroment Continuous reactor Shear protection Reactor oxygenation Bioprobes

Consumer & diversified cosmetics detergents (enzymes) sanitary (active, aromas)


0

200

400

600

800

1000

1200

1400

1600

1800

2000

Num

ber o

f doc

umen

ts

1965

1967

1969

1971

1973

1975

1977

1979

1981

1983

1985

1987

1989

1991

1993

1995

1997

1999

2001

2003

Year

Non-patent (7500)

Patent (11000)

non patents (7500)

patents (11000)

2000

1500

1000

500

01965 1970 1975 1980 1985 1990 1995 2000

From Bojana boh (2003) MLL vol. 6, Citus Book, london, UK.

Microencapsulation documents referenced in Chemical Abstracts

Microencapsulation : Applications


Encapsulation : methods & technologies

Incorporation du principe actif

liquid in air liquid in liquid

PrillingSpraying

Emulsion

Dispersion

StabilisationSolidification Gelification

PolymerisationCoacervation

Liquide(solution, melting, emulsion, suspension)

Solide

Technics

Coating / agglomeration

Pan reactor / Fluid bed

Stabilisation

Evaporation (drying)Solidification Evaporation

Coalescence

1

2

3

1 5Microemulsion

2 3 4

Chemistry Physicochemistry Physic

Step


Prilling / dropping methods

Principe actif

Prilling Spraying

Dispersion

StabilisationSolidification

Gelification

Polymerisation

Coacervation

Liquide

Evaporation

0-10 kV

Rezonnance Nozzle T.

Jet cutter Electrostaticgenerator

Rotative or spinning disk

liquid in air


http://www.nisco.ch

Prilling / Electrostatic generator

Principe actif

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

0-10 kV

low dispersion (20 %)50 to 1000 micrometerslarge range of viscosity viscositylow troughput (10 to 100 ml/h)

U

liquid in air


Prilling / Rezonnance Nozzle Technology

Principe actif

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

low dispersion (5-10 %)high troughput (0.1 to 2 l/h)100 to 1000 micrometersincluding medical applicationslow viscosity

http://www.inotech.ch

liquid in air


Prilling / Jet cutter

Principe actif

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

low dispersion (5-10 %)high troughput (0.1 to 5 l/h)300 to 1000 micrometershigh viscosity

http://geniaLab.de

pectate beads with TiO2 and vitamine, Ø 500 µm

liquid in air


www.swri.org

Particle and coating technologywww.pctincusa.com

Prilling / Rotating devices

Principe actif

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

www.niro.com

liquid in air


Prilling / Stabilisation

Principe actif

Prilling Spraying

Dispersion


GelificationCoacervation

Liquide

Evaporation

Gel

Gelation bath

Melted material

Coldair or water

polymer+ solvent

Hot air

Polymer-

Polymer+

Solidification

Gelification

InterfacialCoacervation

Evaporation or drying

liquid in air

inner core = solution, emulsion, suspension, powder


Prilling / Coextrusion

Principe actif

Prilling Spraying

Dispersion


GelificationCoacervation

Liquide

Evaporation

liquid in air

http://www.inotech.ch


Spraying / Stabilisation

Principe actif

Pulvérisation

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

http://www.niroinc.com/


Pulverisation / stabilisation

Principe actif

Pulverization

Prilling Spraying

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

Spray dryingspray = aqueous solutionhot air

! over heating! low initial dry matter! matrix structuration

Spray chillingspray = thermogelcold air + drying air

Spray cooling or congealingspray = hot meltcold air> high yield, fast process

Spray = solution, emulsion, suspension

http://www.nutriprocess.com/

http://www.innov-ia.com/


membrane formingmaterial + cells

Cross-linkerVegetable ormineral oil

static mixers

Batch processTurbine reactor

Continous processStaticmixers

Emulsion / dispersion

Principe actif

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

liquid in liquid

Emulsion Microemulsion

fast dispersion (< 1 sec)high troughput (m3/h)Cheap, easy


Acid dichloride(Poly)amine

Oil

(Interfacial)Polymerisation

Solvent

water

Polymer + solvent

Solvent evaporation or extraction

Acid or salt

Polymer(s) solution

Oil

Coacervation

Alginate +CaCO3

Aceticacid

Vegetal Oil

Internal gelationPrincipe actif

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

liquid in liquid


K-carraghenane

Vegetal Oil

Thermal gelation

Emulsion / stabilisation

inner core = solution, emulsion, suspension, powder


Principe actif

Dispersion


Gelification

Polymerisation

Coacervation

Liquide

Evaporation

liquid in liquid


nanoencapsulation

surfactant

Nanoencapsulation & molecular inclusion

Liposomes

molecular inclusion


Coating - pelletizing - layering

Principe actif

Solide

Technics



Stabilisation

SolidificationEvaporation

Coalescencehttp://www.glatt.dewww.encap.com


Fluid bed technologies

Principe actif

SolideTechnics



Stabilisation

Solidification

Evaporation

Coalescence

http://www.glatt.de

Rotor sprayvery dense coating

spheronisationlow drying capacity

lower cooling capacity

Top spray Coating & DryingHot melt coatingAgglomerationHigh capacitypoor coating

WursterCoating & Dryinglower capacity

more homogeneous coating


Advances coating technologies

Principe actif

SolideTechnics



Stabilisation


Coalescence

Pan coaterCoating & agglomeration

dry powder coatinglarge particleslower capacity

Continuous coaterlower cost

higher capacity

Spouted bedbetter particle circulation

better temperature controle

T<


Coating / stabilisation processes

Principe actif

SolideTechnics



Stabilisation


Coalescence

Evaporation (spray coating)spray = solutionhot air! slow process! energy demand

Coalescence (dry powder coating)spray = fine powder + plastifiantair at room temperature

Spray = solution, emulsion, suspension, powderpolymer, filler, surfactant, active

Solidification (hot melt coating)spray = hot meltcold air air

http://mcc-ch.org

www.syntapharm.com


1000 groupsover 80 countries(30 % industrials)

research coordination over 25 (-> 35) countries

Topical team to develop research projects

European plateform for promoting encapsulation industrial business

Marie Curie thematicnetwork

UNESCO/INTAS network

Fluid bed technologies

http://bioencapsulation.net

http://ncapsolutions.com

http://COST865.bioencapsulation.net

865


http://bioencapsulation.net/XIII_IWB http://bioncap.com

Documents

Denis Poncelet - · PDF fileDenis Poncelet. ENITIAA, BP82225, F-44322 Nantes ... Prilling Spraying Emulsion Dispersion Stabilisation Solidification Gelification Polymerisation