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DELS BIOLOGICS A LES TERÀPIES CEL·LULARS IMMUNOMEDIADES EN EL TRACTAMENT DE MALALTS AMB CÀNCER Societat Catalano-Balear d'Oncologia i Societat Catalana d’Immunologia Introductor: C. Juárez. Moderadora: M. Bonet.

DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

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Page 1: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

DELS BIOLOGICS A LES TERÀPIES CEL·LULARS IMMUNOMEDIADES EN EL TRACTAMENT DE MALALTS AMB

CÀNCER

Societat Catalano-Balear d'Oncologia i Societat Catalana d’Immunologia

Introductor: C. Juárez.

Moderadora: M. Bonet.

Page 2: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Page 3: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

The Hallmarks of Cancer

Hanahan and Weinberg. Cell 2000

Page 4: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Hanahan and Coussens. Cancer Cell 2012

Page 5: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

The primary tumour microenvironment

Joyce and Pollard. Nature Rev. Cancer 2009

Page 6: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

ELIMINACIÓ

SUPERVIVÈNCIA

SUPERVIVÈNCIA

Inducció tolerància

Mecanismes

resistència

Alteració

genètica

Transformació

progressiva

Immunovigilància

Annu. Rev. Immunol. 2003; 21:807-839

Cèl. Normal Cèl. tumoral

Progressió de la cèl·lula tumoral

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8

La respuesta inmune y el cáncer,

conclusiones

Page 9: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Page 10: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Chen and Mellman. Immunity 2013

Page 11: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Park et al. Trends in Biotechnology 2011

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Page 13: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

Page 14: DELS BIOLOGICS A LES TERÀPIES CEL·LULARS … · Tumor immunity Tumor cells Proinflammato cytokines (IL.6 and Tumor growth . Metastasis Associated Macrophage Integrin a4 PI or 37?

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