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Delivering Valued Genomic Products to Livestock Customers

Sue DeNise, Ph.D. Sr. Director, Global Genetics R&D

Veterinary Medicine Research and Development

Predict  The  Future  Now!  

Who We Are u A Pfizer business

u A leading global animal health company

u Working to assure a safe, sustainable global food supply from healthy beef and dairy cattle, swine, poultry, sheep and fish

u Helping dogs, cats and horses live healthier longer lives

What We Do

A leader in discovery, development, and manufacture of veterinary vaccines & medicines

5000+ colleagues worldwide including 800+ veterinary R&D scientists and specialists

Diverse portfolio of leading veterinary products & services for livestock & companion animals

Melbourne  Australia  

Mumbai  (Thane)  India  

Bri=sh  Columbia  Canada  

Kansas  City  Missouri  

Lincoln  Nebraska  

Charles  City  Iowa  

College  Park  Maryland  

Kalamazoo  Michigan  

Louvain-la-Neuve Belgium

Zaventem Belgium

Olot Spain

Lyon France

Sao  Paolo  Brazil  

Shanghai  China  

New  Delhi  India  

PAH Global R&D Network – Genetics Businesses

Genetics Business Locations

Dunedin  New  Zealand  

PAH Leads Industry in Global R&D Investment

Pfizer Merck Merial Elanco, Janssen

Bayer BIVI Novartis CEVA Virbac Vétoquinol

30M 48M 56M

115M 122M 127M 166M

206M 240M

Sources: Pfizer Animal Health actual 2010 R&D spend. Vetnosis July 29, 2011 Income Statement Report of 2010 R&D spend for other animal health companies.

R&D Spend (in $Millions) PAH R&D

$321 million Strategic  Investments  Include:  ü Animal  Gene=cs  ü Diagnos=cs  ü Emerging  Infec=ous  Diseases  

Why Genetics – The Challenge

Source: Food Economics and Consumer Choice (Simmons, 2008)

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Genomic Tools for Dairy Cattle

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U.S  Holstein  Gene0c  Trend  –  Sires  and  Elite  Dams  

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2000   2001   2002   2003   2004   2005   2006   2007   2008   2009   2010   2011  

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AIPL  Bull  PTA   AIPL  Cow  PTA  

Gene=c  Gap  

What is CLARIFIDE® for Dairy? A Portfolio of Predictions and Tools to Implement Genetic Improvement of Commercial Dairy Females

•  A panel of 6,900 (LD) and 50,000 (50K) genetic markers –  USDA Animal Improvement Programs Laboratory (AIPL) –  Derived from 54,001 (50K) marker panel test

•  Delivers genomic predictions for: –  Holstein, Jersey, and Brown Swiss –  30 production, health and type traits –  9 composite indexes

•  Includes markers to: –  Authenticate parentage –  Bolster reliability of genetic predictions –  Help manage inbreeding

CLARIFIDE® Empowers Female Selection

Based on CLARIFIDE in Holstein Cattle. Pfizer Animal Genetics, Data on File

0 10 20 30 40 50 60 70 80

NM$ PL SCS DPR Milk Fat Prot

Rea

liabi

lity

Parent Avg Reliability CLARIFIDE 6K Reliability

What’s a SNP Genotype Worth?

For the protein yield (h2=0.30), the SNP genotype provides information equivalent to an additional 34 daughters

Pedigree is equivalent to information on about 7 daughters

John Cole: aipl.arsusda.gov/publish/presentations/.../NCSU_2012_jbc.pptx

And for daughter pregnancy rate (h2=0.04), SNP = 131 daughters What’s a SNP Genotype Worth?

John Cole: aipl.arsusda.gov/publish/presentations/.../NCSU_2012_jbc.pptx

Genomic Predictions Upper Midwest Dairy (n=240)

Based on CLARIFIDE in Holstein Cattle. Pfizer Animal Genetics, Data on File

R² = 0.2673 Correlation = 0.52

15.000 17.000 19.000 21.000 23.000 25.000 27.000 29.000 31.000 33.000 35.000 37.000 39.000 41.000 43.000 45.000 47.000

-1.500 -1.250 -1.000 -750 -500 -250 0 250 500 750 1.000 1.250 1.500 1.750

Act

ual M

ilk P

rodu

ctio

n (M

E305

)

CLARIFIDE Milk Genomic Prediction Based on AIPL Predictions (DGV April 2011)

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Strategies for Accelerating the Female Genetic Improvement

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Real World Example: Strategic Breeding

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•  California  Dairy  Customer  is  using  sexed  semen  in  beJer  heifers  to  improve  quality  of  future  female  progeny  

•  Strategic  alloca0on  of  sexed  semen  in  top  50%  of  gPTA  heifers  for  Net  Merit  $  

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•  Future progeny of California Dairy will increased genetic progress 134% or $ 224 Net Merit in the next heifer generation

 

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Heifers  

Future  Progeny  

Real World Example: Strategic Breeding

Dairy Solutions Provider

Gene=cs  

Health  

Milk  Quality  

Reproduc=on  

Nutri=on   Ø Comprehensive  porZolio  of  products  and  services    

Ø Deliver  solu0ons  for  technical  business  challenges  

Ø Strive  to  earn  a  place  in  dairy  management  teams  

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Partnering to Deliver Genomic Products

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American Angus Assoc. ANCP Red Angus Assoc NAPCo Ovita

Traits – GE-EPDs & Ranks

•  Calving Ease Direct •  Birth Weight •  Weaning Weight •  Yearling Weight •  Dry Matter Intake (RADG) •  Residual Feed Intake •  Yearling Height •  Scrotal Circumference •  Docility •  Calving Ease Maternal •  Milking Ability •  Mature Weight •  Mature Height •  Carcass Weight •  Fat Thickness •  Ribeye Area •  Marbling Score •  Tenderness

Parentage – HD 50K Features of HD 50K for Angus

HD 50K Information is Integrated into EPDs, Indexes and Accuracy Values

Lot 1 Pfizer Example Reg. No: Tattoo:

GE-­‐EPDs  simplify  selec0on,  ma0ng  and  marke0ng  because  all  available  data  is  integrated,  removing  the  need  to  consider  

individual  sources  of  trait  informa0on.    

Trait Average

Change in EPD from HD 50K1

Average Change in Accuracy with HD 50K

from .052 Accuracy

Approximate Progeny

Equivalents

CED ±1.6 units .24 14

BW ±.45 lb .25 8

WW ±2.2 lbs .23 16

YW ±3.1 lbs .27 20

RADG ±.03 lbs/day .27 13

YH ±.10 in .29 8

SC ±.12 cm .30 9

Doc ±2.9 units .25 8

Milk ±1.2 lbs .15 12

MW ±14 lbs .29 7

CW ±4.1 lbs .17 7

Marb ±.08 units .24 12

RE ±.10 in2 .23 9

FAT ±.01 in .23 11

1Derived from animals with ≤ .30 accuracy. 2Accuracy from pedigree only

Acquiring Technology •  Sponsored  Research  

–  Academic  Ins0tu0ons  –  CSIRO  

•  License  Technology  –  Ovita  –  Australian  CSIRO  –  Gene0c  Condi0ons  

•  Internal  R&D  –  Nelore  predic0ons  –  Global  Angus  predic0ons  

•  Collabora0ve  research  –  Angus  Gene0c,  Inc.  –  Large  Pastoral  Companies  

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R&D Pipeline Decisions “Customer focused”

v Can we use synergies to develop complete solutions for our customer’s challenges? v Health Traits v Diagnostic tools to refine

genomics v Rational use of Pharma/

biopharma products

Integrated Solutions Path Forward

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