Delhi UCSF Jun2009

8/14/2019 Delhi UCSF Jun2009

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HST - in summary:InterConnected Philosophy

Practice

Education

&

Research

Equal Footing:Multidisciplinary

Multicultural/Multiprofessional:Bench to Bedside

Biophysics

EECS CEM

BEH

HSDM

DEAS

NeuroscienceBiology

BCS

ChE

ME

HBS

Sloan

RLE

LCS

AI Lab

Whitehead

CIMIT

CBELEESMTL

AA

MSE

NE

Physics

Media Lab

MathSPLOBL

Steel Lab

NEBBJI

Mol. Med.

MGHSPL

Magnet

Lab

Extensive RootSystem:

Capitalize onEnvironment


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REGIONAL CENTRE FOR BIOTECHNOLOGYREGIONAL CENTRE FOR BIOTECHNOLOGYFaridabad, National Capital RegionINDIA

Autonomous Institution under the aegis of

Department of Biotechnology, Government of India & UNESCO


3/21

Why UNESCO Connectivity and a Regional Emphasis?

The Needham paradox: Although developing societies/economiestraditionally use empirical technologies for social betterment, they face critical

Thus, a diversity of locally driven perspectives on one hand, andexcellence of global standards on the other would be essential in order togenerate competitive human resource for the developing world


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PatientsPatients

CONSTITUENCIESCONSTITUENCIES

StudentsStudents IndustryIndustry

RCB

Academic

THSTI

Translational

CHC

Clinical

Unique CoUnique Co--locationlocation

Tech Animal

Prog 1

Prog 2

Prog 3

Prog 4Domain-specific

centres

Domain-specific

centres

Domain-specific

centres

Health Biotech Science ClusterHealth Biotech Science Cluster

CLUSTER BOARD


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Engineering

Health

Unique NicheUnique NicheInterdisciplinary education and research

Physics

Medicine

Biotechnology Chemistry


6/21

MandateMandate

to provide a platform for interdisciplinary research and education inorder to create human resources required at the biotech interface of

engineering, chemistry, physics and medicine.

to empower human resources critical for a wide range of biotech needsand to seek knowledge-based innovative and context-specific biotechsolutions


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ObjectivesObjectives

To promote capacity building through education, research & development inbiotechnology

To aim for sustainable development through regional and international cooperation

To execute education and expertise building activities to generate knowledge inbiotechnology

To facilitate transfer of knowledge relating to biotechnology at the regional level

To create a hub of biotechnology expertise in the immediate region with global.

To undertake research, development and scientific investigations in collaborationwith other relevant research centres in the region and beyond

To organize scientific symposia & conferences and to conduct expertise buildingworkshops in contemporary areas of Biotechnology

To disseminate the outcomes of research activities through internationalpublications and generation of intellectual property

Promote collaborative research and development networking programmes inspecific areas of biotechnology

To create network of satellite centres in the region


8/21

Regular Faculty

- a framework for faculty recruitment is being worked outin order seek out the best

Adjunct Faculty- from cluster and partner institutions within NCR

FacultyFaculty

Visiting Professorship- Offer five-year lab-visiting professorships

Re-entry Grant- for Indian scientists working abroad

Young Investigator Awards- for outstanding post-doctoral Fellows


9/21

Systems Biology & Rational Drug Design

Analyses of complex diseases for identification ofintervention points

Immediate major areas of researchImmediate major areas of researchThese are only indicative and not restrictive

Development of knowledge-based drug discoveryapproaches

Regenerative Medicine & Tissue Engineering

Application of novel engineering and material scienceapproaches to understanding and building tissue

architecture

Nanoscience for Biotechnology

Design of novel nanodevices for biosensing, diagnostic andtherapeutic utility


10/21

Educational approachesEducational approaches

Regional participation

Interdisciplinary doctoral programmes Integrated programs through participation of domain-

specific networked centres and in RCB groups as theyeve op

Special-domain workshops & post-graduateprogrammes

Intensive short-term workshops with global faculty andstructured postgraduate progammes


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Regional Centre for BiotechnologyRegional Centre for BiotechnologyA University of Higher Education and Research in Biotechnology

With active contributions from the institutions within the Cluster/vicinity andfrom the larger world providing a meeting place where innovation, enterprise,and industrial development will germinate.


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Vaccine and InfectiousDisease Research Center

at

Translational Health Science andTechnology Institute(THSTI)


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Vision

To improve human health through research directed

at the prevention, intervention, and therapy for

infectious diseases that pose a serious threat to

humanity

Mission

To study infectious diseases and pathogens to

generate translatable knowledge for developingprophylactic and therapeutic measures against

diseases prevalent in India


14/21

Aims and Objectives

In pursuit of its mission, the VIDRC will:

Conduct a comprehensive research program spanningbasic through translational research,

Serve as a national resource for biomedical researchersy prov ng access o qua e sc en s s,

Establish partnerships with industry and academia

Develop national and international collaborations, and

Serve as a center of excellence for training futureresearchers in the fields of science and technologyrelevant to the vaccine and infectious disease research


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Identify virulence properties of the pathogens through studies of

molecular pathogenesis to construct vaccine candidates andtheir pre-clinical evaluation.

Develop of novel vaccine delivery systems including recombinant viral

Vaccine Research at VIDRC

.

Assess the suitability of candidate vaccines in clinical studies.

Measure human immune responses to vaccines.

Evaluate the efficacy of candidate vaccines in large-scale fieldtrials.

Advise governments and health management agencies on

vaccine policy.


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Infectious Disease Research at VIDRC

Strengthen basic and applied research on the pathogen, host and

environmental factors that influence disease emergence

Use knowledge of pathogen, host, and environment interactions to

enhance our ability to predict and prevent conditions that lead to human

disease

Support sequencing and post-genomics research of emerging infectiousdisease agents and animal vectors to reveal genetic basis for pathogen

evolution, adaptation, and pathogenicity

Develop new strategies to control diseases that are re-emerging due to

drug or insecticide resistance and identify better control strategies forintractable infectious diseases that continue to challenge global health

Maintain and develop the scientific expertise required to respond to

future health threats by supporting research and training programs


17/21

DUSCNII / ICGEB

Newadjuvantsand vector

development

Vaccineantigen

discoveryEstablishpartnerships

Pathogen & Disease biology studies

CDC

WHO

Functioning of VIDRC

VIDRC

NDSA

Clinical development of vaccines through various stages and datamanagement, vaccine need forecasting, market evaluation, policy advice,

IP evaluation and protection

with

internationalvaccine R&Dinstitutionsand funding

sources

PATH

NIH

SASClinicalTrials

cGLP,cGMP and

BSL3facility for

DBT


18/21

Key activities

Basic Research (Lab, patient or population based)

Translational biology, Bioprocess, formulation and Analytical research

Clinical development through Phase-I, II and III (SAS and NDSA)

Population based studies on IDs (SAS, NDSA, other partners)

Project management (SAS, NDSA)

Licensing and Business development


19/21

Scientific activities of VIDRC

Toxicology

Process

Pre-clinicalDevelopment

ProtocolDevelopment

QC assays Vaccine Release Tests

Development

AdjuvantResearch

VaccineDelivery Immunology

Candidate Vaccine

eve opmen

Clinical Trial

Efficacy Assaysand validation

For Furtherimprovement

Biomarkers

Cohorts

SurveillanceInfectious Disease

Research

and approval

recruitment

and trialmonitoring

Data storageand analysis

VIDRC activity

SAS activity


20/21

Scientific program of VIDRC (ongoing research activities)

Oral Rotavirus vaccine 116E clinical development programCompleted phase II trial in childrenInterference trial with EPI vaccines to be taken up shortly

Disease burden and RV genotype prevalence studies plannedPhase III efficacy trial of vaccine under planning

Tuberculosis vaccine development programrBCG expressing 85C and other antigens developed

Constructs to be humanized for phase I trialJapanese encephalitis vaccine development programProcess for a tissue culture derived JE vaccine transferred to industry where ithas been scaled uprAd5 expressing novel JEV antigen provides robust protection in animal studies

Exploring ovine adenovirus based delivery of JEV antigenDeveloping infectious clone of JEV to generate attenuated viruses

Development of novel viral vectors for antigen deliveryNovel adenoviruses from animals (fowl and buffalos) being isolatedThese will be characterized genetically and developed as vectors for antigen

delivery


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New Research Activities of VIDRC ????Hepatitis E

Vaccine development

Why Neutralizing abs decline faster?

Immune responses in pregnant women (why high mortality?)

Noroviruses

Very little data on virus activity in India, strains, genotypes, incidence??

Vaccine develo ment

Leishmania, Pneumococcal and Typhoid vaccines

Vaccine development using genome-based approach and bioinformatics??

Cancer vaccines

HPV, breast/oral cancers

Research on antivirals (RCB will have a strong drug development program)

Development of inhibitors for protease, replicase, helicase (Structure based modeling)

Novel adjuvants and viral vectors

Influenza, HIV, Dengue

Documents

Delhi UCSF Jun2009