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Deadline NewsKavali Lecture Focuses

on Ozone Loss . . . . . . . . . . . . .4

Heroes of Chemistry . . . . . . . . . .4

ACS NewsWelcome—Bonnie Charpentier,

Chair, ACS Board

of Directors . . . . . . . . . . . . . . .2

ACS Task Force Tackles Major

Industry Issues . . . . . . . . . . . .3

ACS Initiatives—Madeleine

Jacobs, ACS Executive

Director and CEO . . . . . . . . . .5

Vendor NewsWorkshops . . . . . . . . . . . . . . . . . .6

Vendor Updates . . . . . . . . . . .7–17

Vendor Photos . . . . . . . . . . . . . .18

2 ACS ShowDaily | TUESDAY 30 August 2011 | Denver

Publisher Kenneth M. Carroll

Editor Sharon Donovan

Art Director Connie Hameedi

Photographers Peter Cutts,

Michael Cutts

Advertising Sales USA

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P u b l i s h e d b y A m e r i c a n C h e m i c a l S o c i e t y

Welcome to Denver! Bonnie A. Charpentier, Chair,

ACS Board of Directors

n behalf of the Board

of Directors, wel-

come to this 242nd

National Meeting

of the American

Chemical Society, focused on the

theme “Chemistry of Air, Space, and

Water.” Occurring during the Inter-

national Year of Chemistry, it is our

opportunity to showcase ACS as an

international model of innovation,

collaboration, and inclusion.

As a member of the Board of

Directors, I particularly enjoy

interacting with ACS volunteers

who give freely of their time and

best efforts, despite being busy with

career and family obligations, to

improve people’s lives through the

transforming power of chemistry. I

want to thank our hosts, the Colorado

Local Section, and many volunteer

members of ACS who made the

technical content of this meeting

possible.

Please be sure to stop by the Expo-

sition in the Convention Center and

visit the ACS Booth. Building on its

successful launch at the spring meet-

ing in Anaheim, this booth features

all ACS products, programs, and ser-

vices together, in one space. This in-

novation is part of our ongoing effort

to make our services, including ACS

Publications, Chemical Abstracts Ser-

vice and the ACS Store, more readily

accessible to our members so you can

easily get answers to your questions

about everything ACS has to offer. I

particularly encourage you to stop by

the Chemistry Ambassadors booth

(Booth 1027) and pick up tips on how

to be more effective on communicat-

ing the value of chemistry. If you are

already an experienced Chemistry

Ambassador, come by and share your

experiences.

At this meeting the Board of

Directors asks for your ideas and

opinions about what ACS priorities

should be for our Society goals. What

challenges or opportunities do you

see affecting the lives of chemists and

the practice of chemistry that should

be addressed by ACS? How do you

think ACS should prepare and assist

its members to excel in this era of

rapid change, globalization, and in-

creasingly urgent science-based chal-

lenges? What are the most important

priorities for our Society to establish

for the next several years?

We are in the process this year of

doing a fundamental rewrite of the

ACS Strategic Plan. We appreciate

any input you have on what the

overarching goals of ACS should be.

Please share your thoughts and ideas

with us. A discussion forum about ACS

strategic priorities has been established

on the ACS Network at communities.

acs.org/groups/acs-strategic-plan. I ask

that you take a moment to comment

there, e-mail strategicplan@ acs.org, or

talk to any member of the Board at this

meeting. We look forward to hearing

from you at any time, though your

input would be greatly appreciated by

Sept. 9 so that it can aid our decision-

making for this major strategic focus.

Together, we will identify a great

path for the future of the American

Chemical Society.

As always, please feel free to

contact me about any ACS matter at

[email protected]. u

O

Introducing C&EN Mobile for Daily News Updates

Keeping up with the latest

chemistry news just became easier

with C&EN Mobile for iPhone, iPad,

and Android. The free app became

available through the iTunes

App Store and Android

Market earlier this month.

C&EN Mobile provides

access to daily news up-

dates from C&EN Online,

analysis, and commentary

from the CENtral Science

blog network, and the latest

chemistry job postings.

Individual issues of C&EN are avail-

able for purchase within the app for

$2.99 each. And all August issues

are FREE. A subscription option for

ACS members should be available

in early 2012.

Features of C&EN Mobile in-

clude:

n Preview each weekly issue’s

table of contents

n Store purchased issues in the

“My Library” feature and read

them offline

n Get instant updates from C&EN

Online using the pull-down

refresh feature on “Latest News,”

“CENtral Science,” and “Jobs”

n Read and comment directly on

posts from the CENtral Science

blog network

n Share stories via email, Face-

book, and Twitter

n View an alternate landscape

layout of the table of contents

for the iPad

This month, C&EN is donating

$1 for each app download (up to

$5,000) to the non-profit Children’s

Safe Drinking Water program.

Visit C&EN at ACS at

Booth 1022. u

ACS ShowDaily | TUESDAY 30 August 2011 | Denver 3

mong the deepening

concerns about the

U.S. job situation, the

American Chemical

Society issued a report

Tuesday that maps critical steps to

pioneer new economic growth.

Innovation, Chemistry, and Jobs

details how one of the nation’s most

valuable economic sectors—the chemi-

cal enterprise—can shift from a histori-

cally commodity-based industry to a

highly productive engine capitalizing

on scientific innovations to stimulate

powerful economic growth.

The report is the result of an

ACS presidential task force ap-

pointed by 2010 ACS president

Joseph Francisco, William E. Moore

Distinguished Professor of Earth

and Atmospheric Science and

Chemistry, Perdue University.

“As this nation continues to

wrestle with growing annual budget

deficits and thorny issues attendant

to the raising of our national debt

ceiling, this report recommends

policy changes that, if enacted, will

help created jobs,” Francisco says.

“And with those new jobs comes

increased revenue for this nation.”

The task force consisted of

eminent scientists from industry,

academia and government—all with

experience in entrepreneurship.

Chaired by George Whitesides,

Woodford L. and Ann A. Flowers

University Professor, Harvard Uni-

versity, the report recommends four

main initiatives for ACS to:

n Develop a single organizational

unit to help entrepreneurs

n Increase advocacy of policies at the

federal and state level to improve

business environmental for entre-

preneurs and startup companies

n Work with academic instituions

and other organizations to

promote career pathways and

educational opportunities that

include entrepreneurship

n Increase public awareness

of the value of early-stage

entrepreneurship

“Innovations in chemical processes

and products are brought to the

market now through complex

relationships between entrepre-

neurs, academia, and large and small

companies,” says Whitesides. “The

biggest single issue is facilitating sup-

port for entrepreneurs in the early

states as they start small companies,

navigate the patent process, identify

larger companies with whom they

can partner, and identify markets.

ACS has the capacity to make these

connections.”

The biotech and technology

industries have pursued similar

models with great success, which

has allowed them to become more

thoroughly embrace technological

advancements than other industries

in recent years. This ability to capi-

talize, develop and commercialize

innovations is where the U.S. has

fallen short in the last 20 years and

that has stymied productivity and

limited economic growth, particu-

larly for the chemical industry, the

task force members agree.

On the plus side, the chemical

enterprise represents one of the

country’s most valuable economic

sectors. At $145 billion, the industry

accounts for more than 10 percent

of U.S. total merchandise exports,

according to the report. The U.S.

produces 19 percent of the world’s

chemicals, more than any other

single country. Additionally, more

than 96 percent of manufactured

goods are touched by the business

of chemistry, employing more than

800,000 people in the industry.

A major goal of the task force is

to support entrepreneurs directly,

according to the report, but it also

notes that reforming the U.S. busi-

ness climate is equally important. u

As the 242nd ACS National Meeting convened at the Colorado Convention Center on Tuesday, crowds flooded into the Exhibition Hall, while more than 7,500 reports on new advances in science were scheduled for release and some 9,500 scientists and others were expected to attend.

ACS Report Commits Resources to Support Chemical Entrepreneurs, Create Jobs, Stimulate National Growth

Legendary industry leaders, including Joseph Francisco, 2010 ACS president, George Whitesides, Robert Grubbs, Pat Confalone, and Michael Lefenfeld (via Skype) were among ACS task force mem-bers who gathered Tuesday to discuss details of an ACS report calling for support of innovation, chemistry, and jobs.

A


ven after many decades

of studying ozone and its

loss from the atmosphere

miles above the Earth,

plenty of mysteries

and surprises remain, including an

unexpected loss of ozone over the

Arctic this past winter, an author-

ity on the topic said Tuesday at the

242nd National Meeting & Exposition

of the American Chemical Society

(ACS). She also discussed chemistry

and climate change, including some

proposed ideas to “geoengineer”

the Earth’s climate to slow down or

reverse global warming.

In a Kavli Foundation

Innovations in Chemistry Lecture,

Susan Solomon, of the University

of Colorado, Boulder, said that the

combined efforts of scientists, the

public, industry, and policy makers

to stop ozone

depletion is

one of science’s

greatest success

stories, but

unanswered

questions

remain. And

ozone is still

disappearing.

“We’re no

longer produc-

ing the primary

chemicals—

chlorofluorocar-

bons (CFCs)—

that caused the

problem, but

CFCs have very

long lifetimes in our atmosphere,

and so we’ll have ozone depletion

for several more decades,” she says.

“There are still

some remark-

able mysteries

regarding ex-

actly how these

chlorine com-

pounds behave

in Antarctica—

and it’s amaz-

ing that we still

have much to

learn, even after

studying ozone

for so long.”

The ozone

layer is crucial

to life on

Earth, forming

a protective

shield high in the atmosphere that

blocks potentially harmful ultravio-

let rays in sunlight. Scientists have

known since 1930 that ozone forms

and decomposes through chemical

processes. The first hints that human

activity threatened the ozone layer

emerged in the 1970s, and included

one warning from Paul Crutzen that

agricultural fertilizers might reduce

ozone levels. Another hint was from

F. Sherwood Rowland and Mario

Molina, Ph.D., who described how

CFCs in aerosol spray cans and other

products could destroy the ozone

layer. The three shared a 1995 Nobel

Prize in Chemistry for that research.

In 1985, British scientists discovered

a “hole,” a completely unexpected

area of intense ozone depletion over

Antarctica. Solomon’s 1986 expedi-

tion to Antarctica provided some of

the clinching evidence that under-

pinned a global ban on CFCs and

certain other ozone-depleting gases. u

wo scientists developed

a new drug that helped

pioneer the era of

“personalized medicine”

for cancer patients, an

approach in which one-size-fits-all

drugs yield to medicines custom-

ized to the genetic endowment of

individual patients. Another scien-

tist invented today’s predominant

technology for genetic sequencing,

deciphering the genetic blueprint in

the DNA that makes up the genes of

living things.

The American Chemical Society

(ACS) honored all three Monday at

the ACS 242nd National Meeting &

Exposition, inducting pharmaceutical

researchers Keith Gibson and An-

drew Barker, as well as DNA sequenc-

ing pioneer George Trainor, into

its scientific “hall of fame,” the ACS

Heroes of Chemistry. Established in

1996, the ACS Heroes of Chemistry

program recognizes scientists whose

work in various fields of chemistry

and chemical engineering has led to

the successful innovation and devel-

opment of commercial products.

ACS is honoring Gibson and Barker

for research at AstraZeneca, the global

biopharmaceutical company, on the

compound that became a new drug

named Iressa (gefitinib) for certain

patients with advanced non-small cell

lung cancer (NSCLC). Barker currently

works for AstraZeneca, and Gibson is

retired from the company.

The most common type of lung

cancer, NSCLC accounts for about

85 percent of the 1.6 million new

cases of lung cancer that occur each

year around the world. As of Janu-

ary 2011, Iressa was approved in

76 countries, and sales totaled $637

million in 2010.

Iressa helped pioneer personal-

ized medicine for advanced NSCLC

in the sense that it works specifically

for NSCLC patients who have certain

genetic mutations in their tumors.

Trainor developed a new way to

read, or sequence, the genetic code

in the late 1980s, while he was in

the Central Research Department of

DuPont. Unlike the traditional Sanger

method, Trainor’s fluorescence-

tagged terminator strategy could eas-

ily be automated and did not require

use of radioactive substances. Auto-

mation of DNA sequencing allowed

scientists to analyze unprecedented

amounts of DNA, making it possible

to decode an entire human genome

containing more than 3.4 billion

base pairs (or rungs on the double

helix) and 20,000-25,000 genes. The

approach is now the dominant DNA

sequencing method. Trainor is cur-

rently an independent pharmaceuti-

cal consultant, but developed the

method while employed at DuPont.

DuPont sold Trainor’s DNA

sequencing method under the

name Genesis 2000 DNA Analysis

System and later licensed the

technology to Applied Biosystems.

The market for DNA sequencing

methods is expected to exceed $1

billion this year. u

New ‘Heroes of Chemistry’ Pioneer Personalized Medicine, Decoding Genes

Left to right, Keith Gibson and Andrew Barker, both of AstraZeneca, and George Trainor of DuPont

Mysteries of Ozone Depletion Continue 25 Years After Discovery of the Antarctic Ozone Hole

E

T


ACS Focus on Jobs for Members Takes Top Priority With Numerous InitiativesMadeleine Jacobs, ACS executive

director and CEO

nemployment

remains

unacceptably high,

housing starts are

lagging, Standard

and Poor’s has downgraded the

U.S. credit rating for the first time

in decades, and there are not too

many bright spots in the U.S.

economy. The last time chemists

saw an outlook this grim, the year

was 1971. That is a year many of

us remember well: New PhDs were

unemployed and seasoned chemists

lost their jobs in large numbers. The

fact that the economy eventually

recovered and the employment

outlook brightened is not much

consolation for ACS members who

are struggling today.

Back in the late 1960s and

early 1970s, ACS established a

robust suite of career services

for its members, which has been

continually reinvented and

expanded ever since. I invite you

to visit the ACS website, www.

acs.org, and click on the Careers

tab at the top. There is a wealth of

information, programs, and services

for members to help them with their

career planning. At this national

meeting, we also are hosting

workshops, interviews, résumé

reviews, and other traditional onsite

career fair activities.

We are also holding a greatly-

enhanced virtual career fair on

a new technology platform in

connection with the national

meeting. For the first time, the

career fair will be a true hybrid

event, fully integrating the virtual

career fair into the onsite career

fair in Denver. This innovative

onsite/online program will offer

job seekers more venues to connect

with prospective employers

and various programs to gain

knowledge and career skills. Virtual

participants will be able to interact

with onsite attendees and speakers

through webcams and workstations,

while onsite attendees will

also have access to on-demand

presentations.

At this meeting,

we have also hosted a

webinar with Harvard

University Chemistry Pro-

fessor and serial entrepre-

neur George Whitesides

and 2010 ACS President

Joseph Francisco of

Purdue University on the

recommendations from

an ACS Presidential Task

Force on Innovation. The

Task Force was appointed

by Dr. Francisco in May

2010 and finished its work

in March 2011. The report,

“Innovation, Chemistry,

and Jobs” may be accessed

at www.acs.org/creating-

jobs. The report’s recom-

mendations focus on how

ACS can help stimulate

job creation through

entrepreneurial initia-

tives. Many initiatives are

already underway, thanks

to the work of ACS staff

and various

ACS divisions

and committees;

new initiatives

are also being

planned. More

publicity on

these initia–

tives will be

forthcoming.

Finally, ACS

is developing

new ways of

assisting

members,

whether students

or seasoned

professionals.

ACS has

launched a new

effort to

encourage

members to help other members

find jobs, while bolstering the role

of local sections. An Aug. 8 C&EN

Comment by ACS president Nancy

Jackson calls on all members to

support job seekers and share job

leads through a new “Paying it

Forward” employment forum on the

ACS Network (www.acs.org/

payingitforward).This Comment is

being followed by a series of four

related C&EN Comments on

networking, employment trends,

and job creation. In addition, a

groundbreaking onsite and online

Global Networking Reception is

also being held at this meeting

where national meeting attendees

and members online will learn how

to build networking relationships

and then put those skills into

practice.

Every member of the ACS Board

of Directors and every ACS staff

member is focused on providing

as much assistance as possible to

help our members find jobs. Be sure

to visit the ACS Careers website

frequently for updates on new

services. u

U


Exploring the Chemistry of Air, Space and Waterhatever your

research inter-

est—rocket

propulsion, ar-

tificial sweeten-

ers, or “fracking” and groundwater

contamination—the CAS databases

cover it. SciFinder, the world’s best

chemistry research information

tool, provides access to the CAS

databases, including CAS Regis-

stry, the gold standard for chemical

substances that has now surpassed

61 million small molecules.

New SciFinder features like

SciPlanner take synthesis planning to

a new level and allow users to search

and manage synthetic pathways,

quickly organize answer sets, and

communicate learnings with col-

leagues. Researchers can also connect

with SciFinder Mobile, a smartphone-

optimized version of SciFinder that

provides anytime, anyplace access to

chemical structures, nomenclature,

and properties, plus abstracts of the

latest scientific research.

The CAS booth features an up-

close look at SciFinder and other

CAS products, and its presentations

dive into the databases and search

tools that will help organizations

stay on the cutting edge of scientific

discovery.

Among the topics that CAS is presenting:

n What does a pharmaceutical

researcher to do? In patent litera-

ture, early-stage drug candidates

are often disclosed only by struc-

ture, and sometimes the structure

is embedded in a Markush group.

In CAS Databases as Key Sources

of Pharmaceutical Information,

Elaine Cheeseman will show that

by using STN to search, users can

efficiently locate information of

interest and analyze the retrieved

results with advanced tools such

as STN AnaVist.

n Need to quickly locate informa-

tion on regulated substances?

In CHEMLIST: Chronicling the

Course of Regulated Chemistry,

CAS content manager Roger

Schenck explores the riches of

this CAS database, from polymers

and polymer blends to complex

biological entities—and also

describes CAS techniques for

representing these commercial

substances in the CAS Registry.

Visit CAS at Booth 1022. u

W

New Website, Expanded Library Add to Building Blocks of ServicesThe kinase-focused KINACore Library has

been expanded to over 8,000 compounds.

The increase represents the addition of

compounds that scored highly against

pharmacophore models created from known

kinase actives. The IONCore Library of more

than 4,000 compounds includes compounds

that scored highly against pharmacophore

models created from known ion channel

actives, and the NHRCore Library is

composed of more than 1,000 compounds

that scored highly against pharmacophore

models created from known nuclear hormone

receptor actives. Clients can purchase the

complete libraries or make a custom selection.

New Corporate Website LaunchedTo provide customers with more convenient

access to information and files on its prod-

ucts and services, ChemBridge has launched

a totally new corporate website. Clients now

have the option to create individual accounts

where they can access both standard and

custom chemical structure files, upload data

to ChemBridge and access other technical

information. Product information has been

reorganized, and a site search function has

been added to make access to information

based on key words quick and easy for

clients. The new site also provides more op-

tions for accessing its Hit2Lead.com online

chemical store, which allows users to search

by ID or chemical structure, view up to date

availability information, access its San Diego-

based Rush stock of screening compounds

and building blocks, and to place orders.

Building BlocksChemBridge continues to grow its collec-

tion of commercially available reagents and

now offers over 13,000 building blocks for

synthesis of molecules ideal for hit-to-lead

and lead optimization programs. Its products

can be ordered online from www.Hit2Lead.

com, where most building blocks are avail-

able for overnight delivery from San Diego

stock in pre-packaged 1g and 5g amounts.

Hit2Lead.com offers clients a direct ordering

solution for Building Blocks and Screening

Compounds and allows customers to search

and order ChemBridge products by chemi-

cal structure, sub-structure or similarity. You

can also search by compound ID, name or by

uploading an SD file or ID list.

Custom Synthesis and Re-SynthesisChemBridge offers the following custom syn-

thesis and re-synthesis services: custom build-

ing blocks, monomers, scaffolds or fragments,

synthesis or re-synthesis of leadlike or druglike

compounds from ChemBridge, other sources, or

from published articles, in addition to analogs

for SAR studies or hit expansion.

Visit ChemBridge at Booth 818. u

Chemistry Reactor System for Fluorine Applications

Ace Glass introduces

an all-PTFE reactor

in 250mL, 500mL,

or 1000mL sizes for

fluorine chemistry ap-

plications. The reactor

is comprised of a solid

PTFE filter reactor body

with PTFE bottom valve

and filter assembly; a

solid PTFE reactor head

with PTFE standard

taper joints; and a PTFE

stirrer bearing, stir shaft, and agitator assembly.

PTFE accessories such as baffle, additional funnel,

and condenser are also available. The reactor can

be used for strong alkaline reagents and in areas

where glass could react with the process.

Ace Glass is celebrating its 75th anniversary

manufacturing glassware and equipment, as well

as both bench- and process-scale reactors, for the

scientific lab and process industries.

Founded in 1936 in Vineland, NJ, Ace Glass is

a leader and innovator of scientific glassware, lab

equipment and glass apparatus. The firm’s inno-

vations and inventions include the first American

made spherical joints and sintered-glass fritted

disks. Ace also designed and patented the first

internally threaded glassware—Ace Threds—plus

Ace Trubore Precision Bore Tubing and Insta-

therm oil baths.

Visit Ace Glass at Booth 923. u


Asylum Research is introducing

Electrochemical Strain Microscopy

(ESM), an innovative new scanning

probe microscopy (SPM) technique

for energy storage research and

development.

Developed by the Oak Ridge

National Laboratory and Asylum

Research, ESM is a SPM technique

capable of probing electrochemical

reactivity and ionic flows in solids

on the sub-ten-nanometer level,

three to four orders of magnitude

below the effective resolution

of conventional electrochemical

methods. While scanning tunnel-

ing microscopes (STMs) measure

electronic currents and atomic

force microscopes (AFMs) measure

forces, ESM is the first technique

that measures ionic currents,

providing a new tool for mapping

electrochemical phenomena on the

nanoscale.

In ESM, a biased SPM tip

concentrates an electric field in a

nanometer-scale volume of material,

inducing interfacial electrochemical

processes at the tip-surface junction

and ionic currents through the

solid. The intrinsic link between

concentration of ionic species and/

or oxidation, states of the host

cation and molar volume of the

material results in electrochemical

strain and surface displacement.

The sensitivity of standard SPM

platforms allows for detection of

~2 to 5 pm (1 picometer (pm) =

10-3 nanometers (nm) or 10-12 m)

surface displacements in the ~0.1

to 1 MHz frequency range, which

allows the theoretical detection

limits to be estimated as ~20%

changes in lithiation state within

one unit cell (i.e., elementary

volume of material) for materials

such as LiCoO2 (the most common

cathode component).

The capability to probe electro-

chemical processes and ionic trans-

port in solids is invaluable for a broad

range of applications for energy

generation and storage (batteries, fuel

cells). The viability of electric vehicles

and grid storage as key components

of renewable energy technology

hinges on advances in battery energy

densities and lifetimes. ESM has the

potential to aid in these advances

with two major improvements over

other current technologies: (a) the

resolution to probe nanometer-scale

volumes and (b) imaging capability

extended to a broad range of spec-

troscopy techniques.

To date, ESM has been has been

demonstrated for a variety of lithi-

um-ion materials, including layered

transition metal oxide cathodes,

silicon anodes, and electrolytes such

as LISICON; oxygen electrolytes,

including yttria-stabilized zirconia

(YSZ) and samarium-doped ceria;

mixed electronic-ionic conductors

for fuel cell cathodes; and some

proton conductors. In addition,

because electrochemical strains are

ubiquitous in virtually all solid-state

ionics, ESM will be applicable to

all battery and fuel cell materials

in energy technologies, as well as

ionic-based memory and informa-

tion technology devices.

Visit Asylum Research at

Booth 508. u

Scanning Probe Microscopy Technique Tailored for Energy Storage Research, Development

Systems Combine For Superior Performance, FlexibilityAgilent Technologies is featuring

its 1290 Infinity UHPLC system

paired with the Agilent 6490 Triple

Quadrupole LC/MS system. This

combination couples unrivalled

LC separation performance and

flexibility with the most sensitive

triple quad mass available.

The Agilent 1290 Infinity UHPLC

is designed to provide highest

speed, resolution, and ultra-sensi-

tivity. Its extremely wide power

range enables use of any particle

type, any column dimensions, or

any mobile and stationary phases.

In other words, it’s a universal

instrument for UHPLC, RRLC, and

HPLC applications. Breakthrough

ISET technology lets the Agilent

1290 Infinity execute other HPLC

and UHPLC methods and deliver

the same chromatographic results

without any change to the instru-

ment or the original method.

The Agilent 6490 Triple Quad

LC/MS delivers attograms limit of

detection and zeptomole sensitiv-

ity with an unprecedented six logs

of linearity. It achieves this by

employing breakthrough iFunnel

technology to dramatically increase

the number of ions that enter the

mass spectrometer. First, Agilent

Jet Stream technology surrounds

droplets at the inlet with a sheath

of superheated gas to desolvate and

concentrate ions near the MS inlet

for more effective sampling. Next,

the Hexabore array of six capil-

laries spread across the ion-rich

confinement zone samples the ions.

Thirdly, an innovative dual-stage

ion funnel efficiently removes

gas while focusing ions into the

entrance of the mass analyzer. The

result is unprecedented sensitivity.

This level of sensitivity is par-

ticularly useful for environmental

applications where parts per trillion

sensitivity is often required and in

the pharmaceutical arena for micro-

dosing, detection of inhaled drugs,

and other high sensitivity applica-

tions. Routine access to such high

sensitivity will create new opportu-

nities for clinical, food safety, and

protein/peptide quantitification. Visit

Agilent Technologies at Booth 1500. u

Mapping of Li-ion diffusion: The topographic image, left, of amorphous Si anode in the Si/LiPON/LiCoO2 thin-film battery structure shows the presence of a number of grain boundaries, as well as extensive surface roughness. The ESM image, right, is obtained by measuring the electrochemical strain hys-teresis loops at each pixel (100x100 pixel image over 1 micron area). The area hysteresis loop is a measure of Li-ion mobility, and is plotted as 2D map (dark blue corresponds to closed loops, red to open loops). The enhanced Li-ion mobility along the sharp grain boundary is clearly seen, as well as localized hot spots on the diffuse grain boundary and within the grains. The effective resolution of ESM for this material is ~ 10nm, providing a high-resolution view of Li-ion dynamics in these materials.


Microwave Peptide Synthesizer Delivers Reliability, Purity Biotage, a supplier of tools and

technology for analytical, medicinal,

and peptide chemistry, has intro-

duced an innovative instrument for

peptide professionals.

The Biotage Initiator+ SP Wave

is a versatile synthesis solution as it

can be used as a standalone peptide

synthesizer or easily converted to

a high specification MAOS system.

It is the ideal development tool

for chemists synthesizing pep-

tides, peptidomimetics and small

molecules using single or multi-step

procedures.

Suited for the small scale synthe-

sis of peptides and peptidomimetics

including PNA using microwave

irradiation, from a scale as low as 5

µmol, the semi-automated operation

can reduce the consumption and

waste of expensive reagents which

occur in other systems due to prim-

ing or use of large dead volumes.

The Initiator+ SP Wave is a semi-

automated, programmable synthesis

system. It includes a large 10” touch

screen, intuitive software, pre- or

self-defined methods, inert gas capa-

bility, vortex and magnetic stirring.

With the recent introduction of

the Initiator Peptide Workstation

and Syro Wave, Biotage now offers

a manual, semi-automatic and fully

automatic peptide synthesis solution

including resins and HPLC columns.

Biotage is the only manufacturer

of traditional, room temperature

peptide synthesizers as well as

microwave peptide synthesizers in

both entry-level and high through-

put configurations.

Visit Biotage at Booth 1416. u

Disposable Tips Pierce Tube, Microplate Septa

Hamilton Robotics introduces disposable CO-RE Piercing Tips for its

MICROLAB STAR and NIMBUS automated liquid handling platforms.

The new proprietary tips are designed to pierce septa, sealing mats, and

foils on tubes and plates. They incorporate carbon fiber reinforcement

and vertical ribbing features to increase rigidity and strength, and a tip

bore that prevents blockage and ensures consistent pressure.

Hamilton Piercing Tips are available in black conductive for liquid

level detection and can handle volumes up to 250 µL.

Hamilton is a leading worldwide supplier of precision liquid handling

equipment, laboratory automation and storage systems, serving custom-

ers in academic and private research laboratories, pharmaceutical and

clinical diagnostic companies, and governmental institutions.

With headquarters in Reno, NV and Bonaduz, Switzerland, both of

which house R&D and production facilities, Hamilton has subsidiaries for

direct sales and service in many countries and works with a wide distributor

network in other regions. u

Peptide Synthesizer Features UV-Monitoring, Feedback Control

The TRIBUTE from Protein Technolo-

gies is a revolutionary peptide syn-

thesizer designed with convenience

in mind. With its compact bench-top

design and simple setup, the TRIB-

UTE is perfect for the novice, while

its powerful features and flexibility

make it perfect for the advanced pep-

tide chemist. With the IntelliSynth

UV-Monitoring and Feedback Control

Option, the TRIBUTE is a powerful

platform for the synthesis of difficult

sequences. Remove the trial-and-

error and make difficult sequences

successfully the first time with UV-

Monitoring on the TRIBUTE. With

never-before-seen features like its full-

color, chemical-resistant touchscreen,

the TRIBUTE will revolutionize the

way make peptides are made.

Special features include the Safe-

Response feature that automatically

drains and rinses the resin with solvent

when an error occurs, as well as email

Notification that can send an email to a

computer or cell phone with the status

of a synthesis, for worry-free operation.

Other features include a workstation

utility, which allows syntheses to be

created on a desktop computer, and

then transferred to the TRIBUTE with

a USB stick.

Protein Technologies, a private

company located in Tucson, AZ,

specializes in the manufacture

and distribution of high quality

peptide synthesizers and reagents.

PTI peptide synthesizers have a

reputation for high performance,

flexibility, and reliability, and are

based on a unique, patented matrix

block technology. PTI has placed

hundreds of peptide synthesizers in

academic institutions, biotechnol-

ogy companies and pharmaceutical

companies worldwide.

Visit Protein Technologies at

Booth 1526. u


New Product Line Enables Rapid Development of AnalyzersStellarNet has introduced the

newest member of the low cost

miniature spectrometer product

line, the DWARF-Star NIR,

along with the recently released

ChemWiz Chemometrics Analyzer

Development Kit (ADK) for

complete multivariate calibration,

analysis, and run-time. The system

enables rapid development of

complex analyzers needed to

provide custom measurement

solutions for many applications and

industries, including food and drug,

chemical, oil and gas, and plastics.

The DWARF-Star NIR spec-

trometer is equipped with a high

performance InGaAs detector array

for the 900-1700nm wavelength

range and achievable resolutions to

1.25nm. The InGaAs PDA 512 pixels

detector (1024 pixels optional) pro-

vides maximum sensitivity and has

an integrated thermo electric cooler

(TEC) maintained at -10 °C. The

miniature spectrometer features no

moving parts making it the most

rugged NIR analyzer on the market.

Its small footprint—5" x 3" x 2"—al-

lows for simple OEM integration or

field portable measurements. Multi-

unit pricing is available making

implementation of NIR spectrosco-

py realistic and affordable for many

new applications.

Each DWARF-Star includes free

SpectraWiz software that offers

many basic spectroscopy applica-

tions as well as high speed spectral

data acquisition with advanced

features, such as time series analy-

sis, baseline correction, and spectral

derivatives. Additionally, a free

developer’s toolbox of source codes,

customizable demo programs, and

full spectroscopy applications in

LabVIEW, Visual Basic, Delphi Pas-

cal, and MS Visual C are provided.

The newly released ChemWiz

ADK is a powerful add-on feature

of SpectraWiz for full spectrum

chemometric analysis of multiple

components. Real-time spectral data

is used to measure concentrations

of up to six components such as

moisture, fat, protein, alcohols, ac-

ids, or chemicals, such as pesticides.

Alternatively, the ChemWiz ADK

can be used to identify samples,

i.e. plastics. A model builder pro-

cesses spectra from a set of known

component concentrations and

variety of spectral pre-processing

techniques can be selected, as well

as multivariate analysis type, such

as partial least squares (PLS). A

cross validation technique improves

the reported statistics indicating ac-

curacy and fitness of the calibration

model created. The ADK includes a

runtime engine that performs the

analysis in real-time with little to no

sample preparation.

StellarNet also offers light

sources, probes, and sampling

accessories to facilitate NIR ap-

plications. StellarNet provides

many other spectrometer models

for UV-VIS analysis and even has

extended range NIR units from

900-2300nm. Dual spectrometer

systems are available providing

complete spectroscopy solutions

from 200-2300nm. StellarNet’s

advanced software combined with

ultra-portable, rugged spectrometers

allow scientists to accomplish just

about any spectral measurement

whether in the research lab, field, or

classroom.

Visit StellarNet at Booth 829. u


Flow Chemistry System Achieves Integration

Flow chemistry promises to open

new synthetic routes and permit

screening of hazardous chemistry

not previously available on the

bench. The new iFlow system from

Reaction Analytics builds on the

iChemExplorer to bring in-line

chemical analysis together with

flow chemistry so the scientist may

see the chemistry as it happens.

This insight can speed the search

for likely candidates.

The iFlow system is easily

configurable for contiguous or

continuous flow. For reaction seg-

ments, iChemExplorer with the

autosampler prepares and injects

iFlow integration with HPLC autosampler

Continued on page 11 l

Electron Microscope Wins R&D 100 Award

The JEOL InTouchScope SEM, a touchscreen-controlled

analytical, portable low vacuum Scanning Electron Micro-

scope, has been recognized by the editors of R&D Maga-

zine as one of the 100 most technologically significant

products introduced into the marketplace over the past year.

“This is a significant honor for JEOL because the InTouchScope is the

first SEM to combine the convenience of multi-touch screen operation,

analytical versatility, and ease of use in a very portable, small electron

microscope. We’re delighted that it has become a very popular product

and that it has been recognized with this prestigious award,” says Donna

Guarrera, SEM product manager at JEOL USA.

Introduced in September 2010, the InTouchScope has been selected

by microscopy labs throughout the U.S. for a variety of routine and

research applications. It features integrated Energy Dispersive Spec-

troscopy (EDS) with the latest Silicon Drift Detector (SDD) technology,

automated stage navigation capability, wireless capability, high and low

vacuum operation, and a magnification range of 5X – 300,000X.

The multi-touch operating screen has the familiar look of today’s

personal electronic media.

The R&D 100 Awards are a benchmark of excellence for industry

sectors as diverse as telecommunications, high-energy physics, software,

manufacturing, and biotechnology. Since 1963, the R&D 100 Awards have

identified revolutionary technologies newly introduced to the market.

Visit JEOL at Booth 1410. u


Wireless Remote Controls Pump SystemThe KNF SC920 Series vacuum

pump system for laboratory pro-

cessing applications is exclusively

equipped for wireless remote con-

trol of all pump operating modes

and functions. The wireless tech-

nology maximizes pump system

flexibility and saves valuable space

by allowing the system to be located

away from process equipment with-

out requiring obstructive cabling.

Users ultimately benefit from the

system’s fast and precise process-

ing, extremely quiet operation, and

easy regulation of all vacuums from

afar using the remote.

This system notably can help mini-

mize energy consumption and costs

with the capability to perform with

the fume hood sash partially or fully

closed. This results in dramatically less

airflow in the hood and reduced need

for lab air-conditioning or heating that

otherwise would be necessary.

All process parameters can be

entered and adjusted using the

system’s portable Bluetooth-enabled

handheld terminal integrating

user-friendly touch screen, rota-

tion knob, and intuitive user guide.

Supported operating modes include

vessel evacuation with adjustable

pump capacity, constant pres-

sure control managed precisely

to selected values,

automatic detection

of a sample’s vapor

pressure, and intel-

ligent regulation of

process pressure.

The pump’s

patented diaphragm

stabilization system

serves to develop

high suction speeds,

even at low pres-

sures, and the

system can be used

with all models of

rotary evaporators.

Flow rates up to 20 l/

min (at atmospheric

pressure) and ultimate vacuum of

1.5 Torr (2 mbar) absolute can be

achieved. The SC920 pump system

can additionally be controlled by a

PC using KNF-supplied Windows-

based software.

Visit KNF Neuberger at Booth

1508. u

reaction mixtures to the reactor

flow. After the reactor, a sample can

be diverted from the flow for an on-

line analysis by LC/MS. For continu-

ous flow, the reaction components

are pumped directly to flow reactor

bypassing the autosampler to make

production volumes. Samples may

be diverted for analysis at anytime

through the flow run.

The iFlow system builds on

concepts proven with the iChem-

Explorer. Use of HPLC modules

makes the system robust and easily

serviceable.

Many of these components

may already be available in the lab

making the integration quick and

inexpensive to implement. With

the iChemExplorer software, all

analytical results are accessible in

real-time. A one-button export to

Microsoft Excel makes the results

ready for presentation and records

as soon as the run is complete.

Visit Reaction Analytics at Booth

1732. u

Reaction Analytics from page 10


Optimizing, Controlling Flow Chemistry with Real-time Analysis of Continuous ReactionsResearchers across academia and

industry are increasingly using

continuous flow chemistry to

develop reactions and processes

with increased specificity, yield

and product quality. Optimization

of this work is often challenging

as offline analytical techniques,

such as HPLC, do not provide the

information required fast enough to

optimize the reaction as it happens.

Mettler-Toledo’s new FlowIR sys-

tem has been specifically designed as

a small, ergonomic in situ analysis tool

and enables the screening and optimi-

zation of flow reactions in real time,

saving valuable time and materials.

Knowing immediately if the

chemistry is at steady-state and

converting to the desired product

is essential information when

developing a robust process in the

shortest possible time. FlowIR can

be interfaced to any continuous

flow reactor system and placed

virtually anywhere in the fume hood

where space is limited ensuring

the system is easy to use. Being

able to monitor the chemistry in

situ ensures the collection of the

best possible reaction information

which is typically not the case for

conventional offline measurement

methods. In addition, not having to

extract samples increases personnel

safety when dealing with highly

toxic, energetic, or unstable materials.

In situ monitoring of a continu-

ous flow reaction by FlowIR

provides chemists with the ability

to know when a process is at steady-

state and if there is any transient

intermediate formation, dispersion

characteristics, etc. With the costs of

materials rising significantly, one

powerful application of FlowIR is

the ability to track the dispersion

characteristic of reagents.

Another key aspect of the small

footprint and ergonomic design

is the ability to stack multiples of

FlowIR instruments in the small-

est space possible. Along with the

powerful iC IR analysis software,

development chemists are able to

use multiple FlowIR systems, for ex-

ample, to follow dispersion profiles

of several reagents in a multistep

continuous flow synthesis of a com-

plex compound. Without the ability

to measure the dispersion profiles

in situ and in real time, chem-

ists have to use excess amounts

of reagents (very expensive) and

ultimately requires an additional

process step to remove the excess

material from the final product.

Stoichiometric control via FlowIR

is a breakthrough in technology for

multistep/reagent synthesis.

Visit Mettler-Toledo at

Booth 1824. u


Galbraith Laboratories, founded in

1950, is recognized as one of the

world’s largest and most experi-

enced independent micro-analytical

testing laboratories specializing in

chemical analysis. More than 750

analytical tests are offered on most

sample types for the detection of

elements on the Periodic Table.

Galbraith provides analytical

testing support from R&D through

product development, handles high-

volume sample submissions as well as

technically complex projects requiring

method development and validation,

and performs analyses on sample

volumes as little as 1 milligram, with

up to 6 method options available for

elements routinely analyzed.

It is compliant with the Code

of Federal Regulations (CFR)

parts 210 and 211 for analytical

subcontract laboratories, is GLP/

cGMP compliant, FDA registered,

and maintains a current ISO 17025

certification (please see www.

galbraith.com/iso17025.pdf for

scope of ISO certified services).

Listed on the Consumer Product

Safety Commission’s website as an

accredited analytical testing labora-

tory, Galbraith provides services to all

segments of business and industry,

government, academia, and other

laboratories. With the high level of

diversity Galbraith encounters in the

types of clients served, there exists

an even greater diversity in sample

types. The various regulatory bodies

and compendial methods complete

the configuration of a well-developed

specialty support lab.

Visit Galbraith Laboratories at

Booth 809. u

Lab Offers 750 Analytical Tests on Most Sample Types

Innovation Addresses LCMS Market

LECO’s Citius LC-HRT repre-

sents a substantive innovation

in High Performance Mass

Spectrometers for the LCMS

market. The system utilizes

LECO’s Folded Flight Path

(FFP) technology to provide

full-range mass spectra at

speeds of up to 200 spectra per

second, and resolutions of up

to 100,000 with high-perfor-

mance mass accuracy. The sys-

tem provides the versatility of

ESI, APCI, and DESI (desorp-

tion electrospray) ionization

sources as options to comple-

ment its high-performance MS

capabilities and unchallenged

dynamic range.

“The Citius LC-HRT sys-

tem provides high integrity,

high information-content

mass-spectral performance,

with the data analysis tools

our customers have come to

expect from LECO,” says Jeff

Patrick, LECO’s separation

science product specialist.

Visit LECO at Booth 706. u


International Centre for Diffraction Data Celebrates Anniversaries

ICDD was established in 1941 as a

non-profit scientific organization

dedicated to collecting, editing,

publishing, and distributing pow-

der diffraction data for the identifi-

cation of crystalline materials. As it

celebrates its 70th anniversary, the

company reflects on its founders’

visions to serve as an organization

dedicated to diffraction technology

and education.

From handwritten entries

to data cards, keypunch cards,

magnetic tape, CDs and DVDs, and

now internet access, the dynamic

organization continues to evolve

along with the community that it

serves. It will continue to be the

world center for quality diffraction

and related data and promote

the application of materials

characterization methods in science

and technology by providing

forums for the exchange of ideas

and information.

This year’s milestones: 70th An-

niversary Servicing the Scientific

Community; 60th Denver X-ray

Conference; and 25th Anniversary

of Powder Diffraction

ICDD’s material identification

databases are designed for rapid

materials identification and

interfaced with diffractometers

and data analysis systems of

the world’s leading software

developers and manufacturers

of X-ray equipment. The File is

available in PDF-2 Release 2011

(243,911 entries); PDF-4+ 2011

(316,291 entries) featuring digitized

patterns, molecular graphics and

atomic parameters; PDF-4/Minerals

2011 (37,642 entries); and PDF-4/

Organics 2012 (470,181 entries).

ICDD promotes the application of

materials characterization methods

by sponsoring the Denver X-ray

Conference; its proceedings,

Advances in X-ray Analysis and the

journal, Powder Diffraction.

Visit ICDD at Booth 1806. u


Extensive Video Series Highlights Education

Syrris has developed a series of

educational videos on its Atlas auto-

mated chemistry systems. Avail-

able to view at www.syrris.com/

videos, the extensive video portfolio

includes: Atlas Overview, Atlas

jacketed vessels, Atlas calorimeter

and Atlas software. With the ability

to perform reactions in jacketed re-

actors, round bottomed flasks, pres-

sure reactors or vials, the system is

ideal for use in applications such

as reaction calorimetry, volumetric

dosing, gravimetric dosing, and pH

monitoring.

As a modular laboratory product

designed specifically for research

and development chemists, Atlas is

a cost-effective and easy-to-use sys-

tem. It offers an automated solution

for a range of functions including

heating, stirring, cooling and auto-

mated reagent addition. Providing

true flexibility, the intelligent Atlas

base can operate as a stand-alone

unit, where it automatically logs all

set-points and sensor data. For more

sophisticated reaction control with

real-time graphs, the Atlas system

can be controlled by the unique

Atlas software.

Visit Syrris at Booth 1815. u


TodayACD/Labs Software for Analytical

Chemistry and Education

Sponsor: Advanced Chemistry

Development, Booth 1818

Room 503, 8:30-11 am

Learn about ACD/Labs’ new

software for analytical chemists

and educators in this interactive

workshop. Chemists can spend

less time on analytical

interpretation and more time

on synthesis by using ACD/

Spectrus Processor, an all-in-one

multi-technique data processing

and chemical characterization

tool. Both educators and

researchers can benefit from

using ACD/I-Lab, an online

service that provides instant

access to spectral and chemical

databases, and predicts

properties based on chemical

structures.

Molecular Modeling with Spartan”10

Sponsor: Wavefunction,

Booth 1516

Room 504, 8:30–11 am

The hands-on course will utilize

Spartan’’10 software to provide an

introduction to the application of

molecular mechanics and quantum

chemical methods to determine

molecular shape, structure,

energies and properties. Topics

include: Description/Examples of

common molecular modeling tasks;

applications describing molecular

structure, properties, reactivity and

selectivity; graphical models for the

prediction/analysis of properties,

reactivity and selectivity;

calculation of Spectra (IR, UV/

Vis and NMR); performance

assessment of molecular mechanics

and quantum chemical Methods;

and data mining (Spartan Molecular

Database, Cambridge Structural

Database). All Attendees will

receive fully functional evaluation

versions of Spartan for Windows,

Macintosh, or Linux.

Desmond Beginner’s Tutorial

Workshop

Sponsor: D.E. Shaw, Booth 938

Room 503, Noon-2:30 pm and

3:30-6pm

D. E. Shaw Research will be

conducting two Desmond 3.0

workshops and tutorials, one

beginner and one advanced. The

workshops will include exercises in

preparing structure files, simulating

the system, and analyzing results.

The beginner workshop will focus

on simple protein simulations

as well as basic workflow issues

and the advanced workshop will

include configuring advanced

options, preparing a membrane

protein simulation, an example of

FEP relative binding free energy

calculation, and, if time permits,

a metadynamics example. Each

participant will have a dedicated

remote server running Desmond

(but must provide their own laptops

to access the server).

Improved Analysis Methods for

Detecting Contaminants of Emerging

Concern in Food and Water

Sponsor: Dionex, Booth 1017

Room 504, Noon–2:30 pm

From pesticides in processed

foods, to dioctyl sulfosuccinate in

waters of the Gulf of Mexico, the

development of analytical methods

for contaminants of emerging

concern is a major area of interest.

The seminar covers analytical

approaches for identification

and quantification of trace-level

contaminants in food and water

E x h i b i t o r W o r k s h o p s

Continued on page 17 l


The determination of

disinfection byprod-

ucts, (DBPs) such as

bromate, chlorate, and

chlorinated halo-

acetic acid is critical

to the management

and protection of drinking water

sources. With Dionex now part of

the Thermo Scientific brand IC/MS

workflows are seamlessly integrated

with automated sample preparation

tools, bringing unique capabili-

ties in sample preparation to the

industry’s leading portfolio of MS

systems, and creating new possibili-

ties for scientific analyses.

Potentially harmful byproducts

can form when chlorine used to

disinfect drinking water reacts with

natural organic matter

and bromide. Increas-

ingly, municipalities

are requiring lower

detection limits for

these compounds.

The Thermo

Scientific MSQ Plus Mass Detector

enables the trace-level quantitation

of disinfection byproducts. Using

the unique specificity and selectiv-

ity of ion chromatography (IC) as

a separation technique, coupled

with mass spectrometric detection

(IC-MS) permits sensitive, direct

injection of samples for the detec-

tion and quantitation of haloacetic

acids and other ionic contaminants

in water.

Visit Dionex at Booth 1017. u

using LC-MS/MS analysis with

charged aerosol detection (CAD).

Use of the CAD with MS/MS

detection permits near-universal

detection in which response

is independent of chemical

structure for accurate quantita–

tion without use of reference

standards. u

Cooling, Heating Features ExcelLauda-Brinkmann’s new LAUDA Integral XT 280 has

an impressive 1.2 kW of cooling capacity at -50 °C, in

addition to a 4.0kW integrated heater. Extreme process

heating and cooling requirements, especially those that

are exothermic in nature, are easily accommodated

via the efficient 2.9 bar pump, with flow rates up to 45

liters per minute, and the small internal bath volume of

only 5.0 liters. LAUDA’s proprietary “degassing feature”

allows for safe and rapid removal of air and other debris from the

heat transfer fluids. The Integral XT 280 is an air-cooled device

eliminating the need for cooling water consumption and special

facility resources. Visit Lauda-Brinkmann at Booth 1829. u

Workshops from page 16

Increase Productivity for MS Systems Dispense Mode for High Pressure, Low Flow Apps

Teledyne Isco’s high precision, high pressure syringe pumps

now offer an easy-to-use dispense mode for applications

demanding precise fluid delivery. Dispense mode

programming allows you to specify volumes from 100 µL

to 1 L in 1 µL increments. Additional programming options

can modify the flow profile of the dispensed volume over

time. This mode can simplify chemical feed for research and

development, pilot plants, and manufacturing.

Visit Teledyne Isco at Booth 1724. u


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