Date Prepared: March 3, 2020 · 2020. 3. 3. · Curriculum Vitae Lance L. Munn, PhD - 1 - Date Prepared: March 3, 2020 Name: Lance L. Munn Education 1987 B.S. summa cum laude Chemical

Curriculum Vitae Lance L. Munn, PhD

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Date Prepared: March3,2020

Name: LanceL.Munn

Education 1987 B.S.

summacumlaudeChemicalEngineering Universityof

Cincinnati1993 Ph.D. ChemicalEngineering&Bioengineering

(Advisor:K.Zygourakis)RiceUniversity

Industry Experience 1984-1986 Co-opEngineer Photolithography/Inkformulation Diconix,Inc. (Kodak)Dayton,OH

Postdoctoral Training 06/93-03/96 PostdoctoralFellow BloodRheology&LeukocyteTrafficking

(Advisors:R.Melder,R.K.Jain)MassachusettsGeneralHospital

Faculty Academic Appointments 1996-1998 Instructor RadiationOncology HarvardMedicalSchool1999-2004 AssistantProfessor RadiationOncology HarvardMedicalSchool2004-present AssociateProfessor RadiationOncology HarvardMedicalSchool

Appointments at Hospitals/Affiliated Institutions 1988-1993 Asst.Fellowof

ImmunologyImmunology M.D.AndersonCancerCenter

1993-1996 ResearchFellow RadiationOncology MassachusettsGeneralHospital2004-2016 AssociateBiologist RadiationOncology MassachusettsGeneralHospital2016-present Investigator MGHResearchInstitute MassachusettsGeneralHospital

Major Administrative Leadership Positions

Local

1995-present Director,Bioengineering,Imaging,andComputingCore,SteeleLaboratories

MassachusettsGeneralHospital

2010-present DeputyDirector SteeleLaboratories,MGH2017 Co-chairandorganizer 2017BostonAngiogenesisMeeting

StarrCenter,Boston

Regional

2006-present ProgramSteeringCommitteeMember CityCollegeNewYork/MemorialSloanKetteringCancerCenterPartnershipforCancerResearch,TrainingandCommunityOutreach


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National and International

2012-2014 ExpertPanelist AssessmentofPhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology(APHELION)inEuropeNCI,OfficeofPhysicalSciencesOncology

2012 Co-ChairandOrganizer USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:“MechanicsinOncology”

2014 Co-ChairandOrganizer MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,OhioStateUniversity

2018 Co-Chair 8thWorldCongressofBiomechanics,Dublin,Ireland

2019-present SABmember SimBioSys,Inc.

Committee Service

Local

1993-present CandidateSearchCommittee SteeleLaboratories,MGH 1993-96 Chair2016-present Co-Organizer,MGHsite HarvardMedicalSchoolVascularBiology

SeminarSeries

National and International

2013 Thesiscommitteemember Univ.Waterloo,MadjidSoltanidissertation2013 President,thesiscommittee InstitutCurie,KevinAlessandridissertation2016 Externalthesiscommitteemember McGillUniversity,S.Ghaffaridissertation

Professional Societies 1993-present AmericanInstituteofChemicalEngineers 1999–2008 sessionchair2001-present BiomedicalEngineeringSociety 2000-2005 sessionchair2002-present AmericanAssociationforCancerResearch 2002-present RadiationResearchSociety 2010-present MicrocirculatorySociety 2009-present NorthAmericanVascularBiologyAssociation 2017-present AmericanAssociationfortheAdvancement

ofScience

Grant Review Activities

6/7/00 TransfusionMedicine NIH(NHLBI)


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AdhocMember3/23/01 OncologicalSciencesRev.Committee NIH(NCI)

AdhocMember6/2/04-6/10/04 FastLanereviewsystem NationalScienceFoundation

AdhocMember3/9/05 MicroscopicImagingStudySection NIH

AdhocMember10/12–10/13/06 TumorMicroenvironment NIH(NCI)

AdhocMember6/4-6/6/07 Modeling&AnalysisofBiologicalSystems NIH

AdhocMember2010-present SystemsBiology,ZRG1VH-D(55) NIH(NHLBI)

Member1/11-3/12 VascularHematologySEP NIH

AdhocMember3/18/14 SEP/ScientificReviewGroupZEB1OSR-C

(M3)ReviewpanelNIH(NIBIB)AdhocMember

11/19/2015 SEP/ScientificReviewGroup2016/01ZCA1TCRB-T(J2)Reviewpanel

NIH(NCI)AdhocMember

4/14/2016 PhysicalSciencesOncologyCenters(U54)Reviewpanel

NIH(NCI)AdhocMember

2014-present ResearchCouncilKULeuven UniversityofLeuven,BelgiumReviewer

2016-present ResearchGrantsCouncil(RGC)ofHongKong

UniversityGrantsCommitteeReviewer

2/19-2/202019 DrugDiscoveryandMolecularPharmacologyStudySection

NIH(NCI)Ad hoc Member

2019-present ITMOCanceroftheFrenchNationalAllianceforLifeandHealthSciences

Inserm,Reviewer

2/19/2020 HypertensionandMicrovasculature NIH(NHLBI)AdhocMember

Editorial Activities (reviewer)

AmericanJournalofPhysiology LabonaChipAnalyticalChemistry LancetOncologyAnnalsofBiomedicalEngineering MicrocirculationBiorheology MicrovascularResearchBiotechniques NatureCellBiologyCancerCell NatureMethodsCancerResearch PhysicalReviewLettersIntegrativeBiology PLoSComputationalBiologyJournalofTheoreticalBiology PNAS


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Other Editorial Roles 2015-present GuestEditor PNAS2017-present Editor Microcirculation

Honors and Prizes 1987 EngineeringHonorSociety,

TauBetaPiUniversityofCincinnati

1989 CoxFellowship RiceUniversity 1991 PhillipsAwardforPre-

doctoralResearchRiceUniversity

1995 Postdoctoraltraininggrant NIH 2000 LJISTravelAward WhitakerFoundation 2006 Outstandingcoverdesign Taylor&FrancisGroup,

ComputationalandMathematicalMethodsinMedicine

Scientificillustrationforjournalcover

2013 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2014 GerritsenAward MicrocirculatorySociety Mostcitedjournalarticle2015 DistinguishedAlumnus

AwardRiceUniversity

2016-present MemberoftheCollegeofFellows

AmericanInstituteforMedicalandBiologicalEngineering

2018 UniversityDelegate,InaugurationofHarvardPresident

RiceUniversity

Formally Supervised Trainees

1996—1998 Hera Lichtenbeld, PhD/Currently:ProjectManagement,PharmaCell,Maastricht,NetherlandsPostdoctoral,Projecttitle:“VascularPermeabilityofIndividualMicrovessels”Published one paper.

1997—2000 Jin Yuan, PhD/Currently:SeniorResearchScientistatGenoceaBiosciencesPostdoctoral, Project title: “Fluid Dynamics and Leukocyte Adhesion” Published three papers.

2001-2002 Cristina Sousa/ Doctoral, Project title: “TraffickingofLymphocytesandMetastaticCancerCells”

1998–1999 Gerald Koenig, MD, PhD/Currently:Cardiologist,HenryFordWestBloomfieldHospital,MIPostdoctoral,Projecttitle:“BiophysicsofLymphocyteAdhesioninTumors”Publishedonemanuscript,grantedF32Fellowship,co-authoredpatent.


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1998—2000 Yong Chang, PhD/Currently:VicePresidentatIntelliaTherapeutics,Inc.Postdoctoral,Projecttitle:“HydraulicConductivityandPermeabilityofEndothelialMonolayers”Publishedthreepapers,oneinPNAS.

1998—2000 Randall Dull, MD, PhD/Currently:PresidentialEndowedChairinAnesthesiology,Director,LungVascularBiologyLaboratory,AssociateProfessor,Bioengineering,UniversityofUtahPostdoctoral,Projecttitle:“PlGF-VEGFSynergyinEndothelialResponses”Publishedtwopapers.

1998—2001 Emmanuelle di Tomaso, PhD/Currently:VicePresident,TranslationalMedicine,SyrosPharmaceuticals,CambridgeMAPostdoctoral,Projecttitle:“PermeabilityofBrainTumorVasculature”Publishedfourpapers,oneinCancerResearchandoneinPNAS;receivedClaflinDistinguishedScholarAward,andMartinPrize

2000—2001 Cristiano Migliorini, PhD/Currently:ExecutiveDirectoratBankVontobelAG,Geneva,SwitzerlandPostdoctoral,Projecttitle:“ModelingFluidDynamicsandLeukocyteAdhesion”Publishedthreepapers.

2000-2002 RobertCampbell,PhD/Currently:AssociateProfessor,MassachusettsCollegeofPharmacyandHealthSciencesPostdoctoral,Projecttitle:“DeliveryofLiposomestoTumorVessels”Publishedonepaper,CancerResearch.

2000-2003 Maximilian Bockhorn, MD, PhD/Currently:Surgeon,DepartmentofGeneral&TransplantSurgery;UniversityHospital,Essen,GermanyPostdoctoral,Projecttitle:“AnalysisofCancerCellsShedfromaSolidTumor”Publishedtwopapers,LancetOncologyandCancerResearch.

2000-2003 Neil Forbes, PhD/Currently:Professor,U.MassachusettsAmherstPostdoctoral,Projecttitle:“TreatingTumorswithPenetratingBacteria”Publishedonepaper,CancerResearch.

2002-2006 Chenghai Sun, PhD/Currently:Sr.ResearchScientist,ExaCorp.,Burlington,MAPostdoctoral,Projecttitle:“Lattice-BoltzmannModelingofHemodynamics”Publishedfivepapers,twoinBiophysicalJournal.

2003-2007 Aaron Mulivor, PhD/Currently:SeniorAssociate,Pharma&LifeSciencesAdvisoryatPwCPostdoctoral,Projecttitle:“BloodDynamicsandAtherosclerosis”

2004-2008 Michael Dupin, PhD/Currently:DirectorofPPNRAnalytics,SVPatCitizensBank,Boston,MAPostdoctoral,Projecttitle:“3DSimulationofBloodRheology”Publishedthreepapers.

2004-2010 Janet Tse/ Currently:PatentAgent,NixonPeabodyLLP,BostonDoctoral,Projecttitle:“TumorSolidStress”Published1paper,PNAS.

2005-2009 Gang Cheng, PhD/Currently:HeadofScientificLiaisonatRocheChinaPostdoctoral,Projecttitle:“CellularmechanismsofAngiogenesis”Published2papers,oneinBlood.


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2006-2009 James Alex Tyrrell, PhD/Currently:VicePresident,PlatformSearchCapabilityatThomsonReutersPostdoctoral,Projecttitle:“QuantitativeImageAnalysisofVascularNetworks”Publishedthreepapers.Co-authoredsuccessfulR01application(R01CA149285).

2006-2011 Delphine Lacorre, PhD / Currently: Research Engineer, Lille, France Postdoctoral,Projecttitle:“EffectsofVascularNormalizationonDrugDelivery”Publishedtwopapers;receivedKomenFellowship.

2006-2011 Walid Kamoun, PhD/Currently:AssociateDirector-ResearchTeamLeader,MerrimackPharmaceuticalsPostdoctoral,Projecttitle:“BloodFlowDistributioninTumors”Publishedfivepapers,oneinNatureMethods;receivedKomenFellowship.

2008-2011 Temitope Sodunke, PhD/ Currently:Strategy,Innovation,MedicalDeviceProfessionalatBDPostdoctoral,Projecttitle:“StromalDeterminantsofCancerCellInvasion”ReceivedMerckPostdoctoralFellowship.

2008-2011 Abhishek Jain, PhD/Currently:AssistantProfessor,TexasA&M;Doctoral,Projecttitle:“BloodMicrofluidics”Publishedthreepapers,oneinLabChip

2008-2014 Jonathan Song, PhD /Currently:AssistantProfessor,OhioStateUniversityPostdoctoral,Projecttitle:“Fluidforcescontrolendothelialmorphogenesis”Publishedthreepapers,PNAS,LabChip,IntegrativeBiology

2010-2015 Christian Kunert, PhD/ Currently:Amgen,Cambridge,MAPostdoctoral,Projecttitle:“Mechanobiologyoflymphatictransport”ReceivedDFGFellowship;publicationinPNAS

2011-2015 Gabriel Gruionu, PhD/ Currently:Instructor,MassachusettsGeneralHospitalPostdoctoral,Projecttitle:“Determinantsofvascularremodelingintumors”Published2patentsandonepaper

2011-2016 Despina Bazou, PhDPostdoctoral,Projecttitle:“Endothelialdynamicsandtumortissueengineering”Published5papers

2012-2019 Nir Maimon, PhDPostdoctoral,Projecttitle:“Communicationbetweenbloodvesselcellsintumors”

2014-2019 Hadi Tavakoli Nia, PhD Postdoctoral,Projecttitle:Quantifyingtumormechanopathologies

2017-present Huabing Li, PhDPostdoctoral,Projecttitle:“Lymphaticvalvemechanics”

2018-present Mohammad Reza NikmaneshiDoctoral,Projecttitle:“Tumorengineeringandangiogenesis”

2019-present Kazumichi Kawakubo Postdoctoral,Projecttitle:“EngineeredPDACtumorsfordrugtesting”

2020-present Mohammad Razavi Postdoctoral,Projecttitle:“Systemsbiologyofanti-cancerimmunity”


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Local Invited Presentations No presentations below were sponsored by outside entities

November3,2008 “Multiscaleanalysesofblooddynamics.”MartinosCenterforBiomedicalImaging,NeurovascularSeminarSeries,MGH,Charlestown,MA

October14,2009 “Blooddynamicsandtumormicro-anatomy.”HarvardCatalyst,CenterforNanoscaleSystemsSpecialSeminar:ApplyingNanoscaleTechnologiesinBiomedicalResearch,CambridgeMA.

November5,2010 “Connectionofvascularnetworksviawrapping-and-tappinganastomosis.”BostonAngiogenesisMeeting,MEEI,2010,BostonMA

March8,2011 "Microanatomyandmechanobiology:howthecellmicroenvironmentinfluencescoordinatedmigrationandvascularmorphogenesis."TopicsinBioengineeringSeminarSeries,HarvardSchoolofEngineeringandAppliedSciences(SEAS),Cambridge,MA.

April21,2013 “MechanobiologyofVascularDynamics.”MechanicalForcesinDevelopmentmeeting,TuftsMedicalSchool,Boston

November7,2013 “Biomechanicalcontrolofvesselmorphogenesis,adaptationandfunction.”BostonAngiogenesisMeeting,MEEI,2013,BostonMA

March8,2013 “VascularBiologyandMechanobiology.”MGHT32LectureSeriesNovember4,2015 “Untanglingtumorvasculature.”BostonAngiogenesisMeeting,MEEI,2015,BostonMA

Report of Regional, National and International Invited Teaching and Presentations Thosepresentationsbelowsponsoredbyoutsideentitiesaresonotedandthesponsorisidentified.

Invited Presentations and Courses

Regional

March31,2009 “Multi-scaleAnalysesoftumorphysiologyandbloodvesseldynamics.”2009SeminarSeries,CenterforFluidDynamics,BrownUniversity,Providence,RI.

National

July23-28,1995 “TheRoleofErythrocytesinLeukocyte-EndothelialInteractions.”AnnualConferenceonBiorheologyandClinicalHemorheology,BigSky,MT.

October4-6,1996 “QuantificationofMetastaticCellArrest,Extravasation,andColonization.”AnnualMeetingoftheBiomedicalEngineeringSociety,PennStateUniversity.

June4,1999 "MolecularDeterminantsofTumorPathophysiology."AmericanAssociationofClinicalChemistryMeeting,Boston,MA

June25-26,1999 “TransvascularTransportinTumors.”8thAnnualWorkshoponAdvancedMethodsofPharmacokineticandPharmacodynamicSystemsAnalysis,LosAngeles,CA.

Jan11-15,2000 "VisualizationandQuantificationofGeneFunctioninVivo.”QuantitativeChallengesinthePost-genomicSequenceEra:AWorkshopandSymposium,SanDiego,CA

January19,2001 “TumorAngiogenesisattheCellularLevel.”(MayoClinic)MayoClinicGoldmanSymposiumonInnovativeResearchinMultipleMyeloma,AmeliaIsland,FL


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April29,2001 “VascularDevelopmentandAnti-angiogenicStrategies.”PediatricAcademicSocieties’2001AnnualMeeting,Baltimore,MD

November8,2001 “Modelingleukocyteadhesioninsmallvessels:aLatticeBoltzmannapproach.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Reno,NV

September6-8,2002

“TumorPhysicsandBiology:ImpactofAberrantVascularArchitectureonTherapy.”ThirdAnnualBioMEMs&BiomedicalNanotechnologyWorld2002Columbus,OH

October25,2002 “InfluenceofVesselGeometryonLeukocyteAdhesion:aLattice-BoltzmannModel.”AnnualMeetingoftheBiomedicalEngineeringSociety,Houston,TX.

February27,2003 “TumorVesselAbnormalitiesandLeukocyte-ErythrocyteDynamics.”PennStateUniversity,StateCollege,PA

November11,2004 “Microfluidicdeviceforauto-separationofwhitebloodcellsfromwholeblood.”PlenaryTalk(selectedabstract),AmericanInstituteofChemicalEngineeringAnnualMeeting,Austin,TX

December1,2004 “Reverseengineeringofbloodcelldynamics.”CityCollegeofNewYork,Fall2004SeminarSeries,DepartmentofBiomedicalEngineering

February17-21,2005

“TheTumorMicroenvironment:ModelingandExperimentalValidation.“MathematicalOncology:BridgingtheScientificDivide,AAASAnnualMeeting,WashingtonDC

May10,2005 “BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”NSTINanotechnologyConference,AnaheimCA

December18-19,2006

“Microfluidicsandparticletransportintumors.”FineParticleSocietyNanotechnologyinLifeSciencesSymposium,SanDiego,CA

December18-21,2006

“BiomimeticDesignofaMicrofluidicDeviceforAuto-separationofLeukocytesfromWholeBlood.”SymposiumonNanotechnologyinLifeSciences20thInternationalConferenceonBioandPharmaceuticalScienceandTechnology,SanDiego,CA

October2-4,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,StLouis,MA

October26-28,2008

“IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”NCIInnovativeMolecularAnalysisTechnologies(IMAT)program,Cambridge,MA

November30,2008 “IsolationofRareCellsfromWholeBloodUsingMicrofluidics.”MaterialsResearchSociety:CancerNanotechnologyMedSchool–RealWorldChallengesandNano’sStrengthsinCancerPrevention,Diagnosis,andTreatment,Boston,MA

January26-30,2009

“Multi-scaletumorphysiologyandbloodvesseldynamics.”MathematicalBiosciencesInstituteWorkshoponCancerDevelopment,Angiogenesis,ProgressionandInvasion,Columbus,OH

October8,2009 “Tumorbloodvesseldynamics.”QuantitativePharmacologyTechnicalSummit(EliLilly),Indianapolis,IN

October7-10,2009 “Tumorbloodvesseldynamics.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Pittsburgh,PA

November23,2009 “Tumorbloodvesseldynamics.”62ndAnnualMeetingoftheAPSDivisionofFluidDynamics,Minneapolis,Minnesota

April24-28,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),ExperimentalBiologyMeeting,Anaheim,CA

October6-8,2010 “Wrapping-and-tappinganastomosisbetweenengraftedendothelialnetworksandhostvasculature.”PlenaryTalk(selectedabstract),AnnualMeetingoftheBiomedicalEngineeringSociety,Austin,MA


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November1-2,2010 “Compression-inducedcancercellinvasion:don’tpushme‘causeI’mclosetotheedge.”UCSD/NSFPhysicsofCancerMetastasisMeetingArlington,VA

April3-6,2011 “Tumorvesseldynamicsduringanti-angiogenictherapy.”AmericanConferenceonPharmacometrics,SanDiego,CA

Aug30-Sept3,2011 “Cell-MatrixInteractionswithinTumorsandNormalTissue.”33rdAnnualInternationalConferenceoftheIEEEEngineeringinMedicineandBiologySocietyBoston,MA

March7,2011 “Tumorbloodvesseldynamics.”PhysicalSciences–OncologyCenterSteeringCommitteemeeting

October28,2011 "Imagingvasculardynamics"MultiscaleSystemsBiologyworkinggroupoftheMultiscaleModeling(MSM)Consortium

October24,2012 “SolidandFluidBiomechanicsintheTumorEnvironment”.USNationalCommitteeonBiomechanics4thSymposiumonFrontiersinBiomechanics:MechanicsinOncology

April2,2013 “MechanobiologyandVascularDynamics,”IMESeminarSeries,UniversityofPennsylvania

September27,2013 "Biomechanicaldeterminantsofcellinvasion,angiogenesisandlymphaticfunction."CusterWorkplaceLectureSeries,UniversityofWesternMichigan

October15,2014 “Biomechanicsofcancerinvasionandvesselfunction.”MathematicalBiosciencesInstituteWorkshoponMetastasisandAngiogenesis,Columbus,OH.

April3,2015 “Deconvolvingtumordynamics.”DepartmentofMechanicalandAerospaceEngineeringSeminarSeries,OhioStateUniversity

March29,2016 “Deconvolvingtumordynamics.”RiceUniversity'sBioengineeringColloquiumOctober27,2016 “SystemsBiologyofLymphTransport.” NHLBISystemsBiologymeeting,Bethesda,MD. April10,2018 “TumorEngineeringandMechanobiology.”DepartmentofChemicalandBiomolecular

EngineeringSeminarSeries,OhioStateUniversitySeptember7,2018 “Engineeredtumorsforpersonalizedmedicine.”DukeUniversityLectureSeries,Durham,

NCMarch5,2019 “Reverseengineeringtumorsandvasculature.”(Keynote)UniversityofNorthCarolina

IntegrativeVascularBiologyresearchsymposium.ChapelHill,NCSeptember12,2019 “Mechanobiologicalcontrolofvascularfunction.”AmericanPhysiologicalSociety

meeting,Interfaceofmathematicalmodelsandexperimentalbiology:Roleofmicrovasculature.Scottsdale,AZ

January20,2020 “ReengineeringthePhysicalMicroenvironmentofTumorstoImproveTreatmentResponse”CambridgeHealthtechInstitute;EngineeringNextGenerationCancerImmunotherapies;Partofthe19thAnnualPepTalk,SanDiego,CA

International

August25-30,1996 “InteractionofActivatedLeukocyteswithTumorVessels.”SixthWorldCongressforMicrocirculation,Munich,Germany

October3-7,1998 “TumorAngiogenesisandMicrocirculation.”10thAnnualConferenceoftheInternationalSocietyofDifferentiation,Houston,TX

Oct22-25,1999 “TumorAngiogenesis.”ConferenceonAngiogenesisandTumors,Paris,FranceOct12-15,2002 “TumorVesselAbnormalities.”SecondInterdisciplinaryEuroconferenceonAngiogenesis,

Cascals,PortugalApril23-24,2004 “Theinteractionofcirculatingcellswithtumors:pharmacokineticandfluiddynamic

models.”WorkshoponMathematicalOncology,TheFieldsInstitute,Toronto,ON


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August1,2006 “Tumorvesselabnormalitiesaffectbloodcelldynamicsandflowdistribution.” CancerandBioengineering;WorldCongressofBiomechanics,MunichGermany

July2-4,2008 “Multi-scaleanalysesoftumorphysiologyandbloodvesseldynamics.”FieldsInstituteWorkshoponGrowthandControlofTumors:TheoryandExperimentToronto,CA

July9-13,2008 “Blooddynamicsinnormalandabnormalvesselnetworks.”InternationalCongressofBiorheology,PennStateUniversity,StateCollege,PA

January4-7,2010 “ModelingTumorbloodvesseldynamics.”WorkshoponMathematicalMethodsinSystemsBiology,TelAviv,Israel

March18-20,2010 “ModelingTumorbloodvesseldynamics.”FieldsInstituteWorkshoponMathematicalOncologyToronto,CA

May10-12,2010 “ModelingTumorbloodvesseldynamics.”CentreEuropeandeCalculAtomiqueetMoleculaire(CECAM)WorkshoponTrendsinComputationalHemodynamics,Lausanne,Switzerland

Sept.17-20,2011 “Vasculardynamicsandanti-angiogenictherapy.”Tumor-VesselInterfacemeeting,KlosterSeeonGermany

March28-30,2011 “Targetingvasculardynamics.”VIIthAcademicianNicolaeCajalSymposium,Bucharest,Romania

December3,2013 “Biomechanicaldeterminantsofmorphogenesisandvascularfunction”InstitutCurie,ParisFrance

May29-30,2014 “Microsystemsforprobingblood,vesselandtumordynamics.”(Keynote)Ontario-on-a-ChipConference,UniversityofToronto,Toronto,CA

July6-11,2014 “BiomechanicalControlofVesselMorphogenesis,AdaptationandFunction.”SeventhWorldCongressofBiomechanics,Boston,MA

July6-11,2014 “Biomechanicalautoregulationoflymphatictransport.”SeventhWorldCongressofBiomechanics,Boston,MA

October2-8,2014 "Biomechanicalprocessesandtopologicaldynamicsintumors"AnnualSymposiumofPhysicsofCancer,UniversityofLeipzig

June25-28,2016 "Visualizingcellandmatrixdynamicsintumors"AACRSpecialConferenceonEngineeringandPhysicalSciencesinOncology,WestinBostonWaterfront,Boston,MA

February5-9,2017 “Tumorsolidstressandmechanobiology”PhysicalScienceofCancerGordonResearchConference,Galveston,TX

Dec.7-10,2017 “Acceleratingrevascularization.”InnovationsinWoundHealingConference,Bimini,Bahamas.

July10,2018 “Leaky Blood Vessels, GAGs and Metastasis” World Congress of Biomechanics 2018, Dublin, Ireland

Report of Scholarship Publications

Peer reviewed publications in print or other media [more than 18,000 citations; h-index= 61 (Google), 56 (Web of Science)]

Research Investigations 1. MunnLL,GlackenMW,McintyreBW,ZygourakisK.Analysisoflymphocyteaggregationusingdigital

imageanalysis.JImmunolMethods.1993;166:11-25.


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2. TeagueTK,MunnL,ZygourakisK,McintyreBW.Analysisoflymphocyteactivationandproliferationbyvideomicroscopyanddigitalimaging.Cytometry.1993;14:772-82.

3. MunnLL,MelderRJ,JainRK.Analysisofcellfluxintheparallelplateflowchamber:implicationsforcellcapturestudies.BiophysJ.1994;67:889-95.

4. MelderRJ,MunnLL,YamadaS,OhkuboC,JainRK.Selectin-andintegrin-mediatedT-lymphocyterollingandarrestonTNF-alpha-activatedendothelium:augmentationbyerythrocytes.BiophysJ.1995;69:2131-8.

5. MunnLL,KoenigGC,JainRK,MelderRJ.Kineticsofadhesionmoleculeexpressionandspatialorganizationusingtargetedsamplingfluorometry.Biotechniques.1995;19:622-6,628-31.

6. MelderRJ,KoenigGC,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-alpha-treatedendotheliumunderphysiologicalflowconditions.NatImmun.1996a;15:154-63.

7. MelderRJ,KoenigGC,WitwerBP,SafabakhshN,MunnLL,JainRK.Duringangiogenesis,vascularendothelialgrowthfactorandbasicfibroblastgrowthfactorregulatenaturalkillercelladhesiontotumorendothelium.NatMed.1996b;2:992-7.

8. MunnLL,MelderRJ,JainRK.Roleoferythrocytesinleukocyte-endothelialinteractions:mathematicalmodelandexperimentalvalidation.BiophysJ.1996;71:466-78.

9. PatanS,MunnLL,JainRK.Intussusceptivemicrovasculargrowthinahumancolonadenocarcinomaxenograft:anovelmechanismoftumorangiogenesis.MicrovascRes.1996;51:260-72.

10. NeelameghamS,MunnLL,ZygourakisK.Amodelforthekineticsofhomotypiccellularaggregationunderstaticconditions.BiophysJ.1997;72:51-64.

11. ShiodaT,MunnLL,FennerMH,JainRK,IsselbacherKJ.Earlyeventsofmetastasisinthemicrocirculationinvolvechangesingeneexpressionofcancercells.TrackingmRNAlevelsofmetastasizingcancercellsinthechickembryochorioallantoicmembrane.AmJPathol.1997;150:2099-112.

12. LichtenbeldHC,FerarraN,JainRK,MunnLL.Effectoflocalanti-VEGFantibodytreatmentontumormicrovesselpermeability.MicrovascRes1999;57:357-62.

13. ChangYS,diTomasoE,McDonaldDM,JonesR,JainRK,MunnLL.Mosaicbloodvesselsintumors:frequencyofcancercellsincontactwithflowingblood.ProcNatlAcadSciUSA.2000a;97:14608-13.

14. ChangYS,MunnLL,HillsleyMV,DullRO,YuanJ,LakshminarayananS,GardnerTW,JainRK,TarbellJM.Effectofvascularendothelialgrowthfactoronculturedendothelialcellmonolayertransportproperties.MicrovascRes.2000b;59:265-77.

15. MelderRJ,YuanJ,MunnLL,JainRK.Erythrocytesenhancelymphocyterollingandarrestinvivo.MicrovascRes.2000;59:316-22.

16. DaviesCdeL,MelderRJ,MunnLL,Mouta-CarreiraC,JainRK,BoucherY.Decorininhibitsendothelialmigrationandtube-likestructureformation:roleofthrombospondin-1.MicrovascRes.2001;62:26-42.

17. DullRO,YuanJ,ChangYS,TarbellJ,JainRK,MunnLL.Kineticsofplacentagrowthfactor/vascularendothelialgrowthfactorsynergyinendothelialhydraulicconductivityandproliferation.MicrovascRes.2001;61:203-10.

18. MelderRJ,KristensenCA,MunnLL,JainRK.ModulationofA-NKcellrigidity:Invitrocharacterizationandinvivoimplicationsforcelldelivery.Biorheology.2001;38:151-9.

19. PatanS,MunnLL,TandaS,RobergeS,JainRK,JonesRC.Vascularmorphogenesisandremodelinginamodeloftissuerepair:bloodvesselformationandgrowthintheovarianpedicleafterovariectomy.CircRes.2001a;89:723-31.

20. PatanS,TandaS,RobergeS,JonesRC,JainRK,MunnLL.Vascularmorphogenesisandremodelinginahumantumorxenograft:bloodvesselformationandgrowthafterovariectomyandtumorimplantation.CircRes.2001b;89:732-9.

21. YuanJ,MelderRJ,JainRK,MunnLL.Lateralviewflowsystemforstudiesofcelladhesionanddeformationunderflowconditions.Biotechniques.2001;30:388-94.

22. CampbellRB,FukumuraD,BrownEB,MazzolaLM,IzumiY,JainRK,TorchilinVP,MunnLL.Cationicchargedeterminesthedistributionofliposomesbetweenthevascularandextravascularcompartmentsoftumors.CancerRes.2002;62:6831-6.

23. FriedrichSW,LinSC,StollBR,BaxterLT,MunnLL,JainRK.Antibody-directedeffectorcelltherapyoftumors:analysisandoptimizationusingaphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:449-63.


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24. KoikeC,MckeeTD,PluenA,RamanujanS,BurtonK,MunnLL,BoucherY,JainRK.Solidstressfacilitatesspheroidformation:potentialinvolvementofhyaluronan.BrJCancer.2002;86:947-53.

25. MelderRJ,MunnLL,StollBR,MarecosEM,BaxterLT,WeisslederR,JainRK.Systemicdistributionandtumorlocalizationofadoptivelytransferredlymphocytesinmice:comparisonwithphysiologicallybasedpharmacokineticmodel.Neoplasia.2002;4:3-8.

26. MiglioriniC,QianY,ChenH,BrownEB,JainRK,MunnLL.Redbloodcellsaugmentleukocyterollinginavirtualbloodvessel.BiophysJ.2002;83:1834-41.

27. PaderaTP,KadambiA,diTomasoE,CarreiraCM,BrownEB,BoucherY,ChoiNC,MathisenD,WainJ,MarkEJ,MunnLL,JainRK.Lymphaticmetastasisintheabsenceoffunctionalintratumorlymphatics.Science.2002;296:1883-6.

28. ForbesNS,MunnLL,FukumuraD,JainRK.SparseinitialentrapmentofsystemicallyinjectedSalmonellatyphimuriumleadstoheterogeneousaccumulationwithintumors.CancerRes.2003;63:5188-93.

29. FriedrichEB,TagerAM,LiuE,PetterssonA,OwmanC,MunnL,LusterAD,GersztenRE.MechanismsofleukotrieneB4--triggeredmonocyteadhesion.ArteriosclerThrombVascBiol.2003;23:1761-7.

30. RooseT,NettiPA,MunnLL,BoucherY,JainRK.Solidstressgeneratedbyspheroidgrowthestimatedusingalinearporoelasticitymodel.MicrovascRes.2003;66:204-12.

31. StollBR,MiglioriniC,KadambiA,MunnLL,JainRK.Amathematicalmodelofthecontributionofendothelialprogenitorcellstoangiogenesisintumors:implicationsforantiangiogenictherapy.Blood.2003;102:2555-61.

32. SunC,MiglioriniC,MunnLL.Redbloodcellsinitiateleukocyterollinginpostcapillaryexpansions:alatticeBoltzmannanalysisBiophysJ.2003;85:208-22.

33. BockhornM,RobergeS,SousaC,JainRK,MunnLL.Differentialgeneexpressioninmetastasizingcellsshedfromkidneytumors.CancerRes.2004;64:2469-73.

34. DudaDG,FukumuraD,MunnLL,BoothMF,BrownEB,HuangP,SeedB,JainRK.Differentialtransplantabilityoftumor-associatedstromalcells.CancerRes.2004;64:5920-4.

35. WillettCG,BoucherY,diTomasoE,DudaDG,MunnLL,TongRT,ChungDC,SahaniDV,KalvaSP,KozinSV,MinoM,CohenKS,ScaddenDT,HartfordAC,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ChenHX,ShellitoPC,LauwersGY,JainRK.DirectevidencethattheVEGF-specificantibodybevacizumabhasantivasculareffectsinhumanrectalcancer.NatMed.2004;10:145-7.

36. WinklerF,KozinSV,TongRT,ChaeSS,BoothMF,GarkavtsevI,XuL,HicklinDJ,FukumuraD,diTomasoE,MunnLL,JainRK.KineticsofvascularnormalizationbyVEGFR2blockadegovernsbraintumorresponsetoradiation:roleofoxygenation,angiopoietin-1,andmatrixmetalloproteinases.CancerCell.2004;6:553-63.

37. DemouZN,AwadM,MckeeT,PerentesJY,WangX,MunnLL,JainRK,BoucherY.LackoftelopeptidesinfibrillarcollagenIpromotestheinvasionofametastaticbreasttumorcellline.CancerRes.2005;65:5674-82.

38. diTomasoE,CapenD,HaskellA,HartJ,LogieJJ,JainRK,McDonaldDM,JonesR,MunnLL.Mosaictumorvessels:cellularbasisandultrastructureoffocalregionslackingendothelialcellmarkers.CancerRes.2005;65:5740-9.

39. KashiwagiS,IzumiY,GohongiT,DemouZN,XuL,HuangPL,BuerkDG,MunnLL,JainRK,FukumuraD.NOmediatesmuralcellrecruitmentandvesselmorphogenesisinmurinemelanomasandtissue-engineeredbloodvessels.JClinInvest.2005;115:1816-27.

40. ShevkoplyasSS,YoshidaT,MunnLL,BitenskyMW.Biomimeticautoseparationofleukocytesfromwholebloodinamicrofluidicdevice.AnalChem.2005;77:933-7.

41. SunC,MunnLL.Particulatenatureofblooddeterminesmacroscopicrheology:a2-DlatticeBoltzmannanalysis.BiophysJ.2005;88:1635-45.

42. WillettCG,BoucherY,DudaDG,diTomasoE,MunnLL,TongRT,KozinSV,PetitL,JainRK,ChungDC,SahaniDV,KalvaSP,CohenKS,ScaddenDT,FischmanAJ,ClarkJW,RyanDP,ZhuAX,BlaszkowskyLS,ShellitoPC,Mino-KenudsonM,LauwersGY.Surrogatemarkersforantiangiogenictherapyanddose-limitingtoxicitiesforbevacizumabwithradiationandchemotherapy:continuedexperienceofaphaseItrialinrectalcancerpatients.JClinOncol.2005;23:8136-9.


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43. JonesR,CapenD,JacobsonM,MunnL.PDGFandmicrovesselwallremodelinginadultratlung:imagingPDGF-AAandPDGF-Ralphamoleculesinprogenitorsmoothmusclecellsdevelopinginexperimentalpulmonaryhypertension.CellTissueRes.2006;326:759-69.

44. DupinMM,HallidayI,CareCM,AlboulL,MunnLL.Modelingtheflowofdensesuspensionsofdeformableparticlesinthreedimensions.PhysRevEStatNonlinSoftMatterPhys.2007;75:066707.

45. JainRK,TongRT,MunnLL.Effectofvascularnormalizationbyantiangiogenictherapyoninterstitialhypertension,peritumoredema,andlymphaticmetastasis:insightsfromamathematicalmodel.CancerRes.2007;67:2729-35.

46. SunC,JainRK,MunnLL.Non-uniformplasmaleakageaffectslocalhematocritandbloodflow:implicationsforinflammationandtumorperfusion.AnnBiomedEng.2007;35:2121-9.

47. JonesRC,CapenDE,CohenKS,MunnLL,JainRK,DudaDG.Aprotocolforphenotypicdetectionandcharacterizationofvascularcellsofdifferentoriginsinalungneovascularizationmodelinrodents.NatProtoc.2008;3:388-97.

48. DupinMM,HallidayI,CareCM,MunnLLEfficiency-oriented,hybridapproachformodelingdeformableparticlesinthreedimensions.ProgressinComputationalFluidDynamics.2008;8109-120

49. MunnLL,DupinMM.Bloodcellinteractionsandsegregationinflow.AnnBiomedEng.2008;36:534-44.50. SunC,MunnLL.LatticeBoltzmannsimulationofbloodflowindigitizedvesselnetworks.ComputMath

Appl.2008;55:1594-1600.51. AuP,TamJ,DudaDG,LinPC,MunnLL,FukumuraD,JainRK.ParadoxicaleffectsofPDGF-BB

overexpressioninendothelialcellsonengineeredbloodvesselsinvivo.AmJPathol.2009;175:294-302.52. ChengG,TseJ,JainRK,MunnLL.Micro-environmentalmechanicalstresscontrolstumorspheroidsize

andmorphologybysuppressingproliferationandinducingapoptosisincancercells.PLoSOne.2009;4:e4632.

53. diTomasoE,LondonN,FujaD,LogieJ,TyrrellJA,KamounW,MunnLL,JainRK.PDGF-Cinducesmaturationofbloodvesselsinamodelofglioblastomaandattenuatestheresponsetoanti-VEGFtreatment.PLoSOne.2009;4:e5123.

54. JainA,MunnLL.Determinantsofleukocytemarginationinrectangularmicrochannels.PLoSOne.2009;4:e7104.

55. KamounWS,LeyCD,FarrarCT,DuyvermanAM,LahdenrantaJ,LacorreDA,BatchelorTT,diTomasoE,DudaDG,MunnLL,FukumuraD,SorensenAG,JainRK.Edemacontrolbycediranib,avascularendothelialgrowthfactorreceptor-targetedkinaseinhibitor,prolongssurvivaldespitepersistentbraintumorgrowthinmice.JClinOncol.2009;27:2542-52.

56. PerentesJY,MckeeTD,LeyCD,MathiewH,DawsonM,PaderaTP,MunnLL,JainRK,BoucherY.Invivoimagingofextracellularmatrixremodelingbytumor-associatedfibroblasts.NatMethods.2009;6:143-5.

57. VakocBJ,LanningRM,TyrrellJA,PaderaTP,BartlettLA,StylianopoulosT,MunnLL,TearneyGJ,FukumuraD,JainRK,BoumaBE.Three-dimensionalmicroscopyofthetumormicroenvironmentinvivousingopticalfrequencydomainimaging.NatMed.2009;15:1219-23.

58. ChaeSS,KamounWS,FarrarCT,KirkpatrickND,NiemeyerE,DeGraafAM,SorensenAG,MunnLL,JainRK,FukumuraD.Angiopoietin-2interfereswithanti-VEGFR2-inducedvesselnormalizationandsurvivalbenefitinmicebearinggliomas.ClinCancerRes.2010;16:3618-27.

59. KamounWS,ChaeSS,LacorreDA,TyrrellJA,MitreM,GillissenMA,FukumuraD,JainRK,MunnLL.SimultaneousmeasurementofRBCvelocity,flux,hematocritandshearrateinvascularnetworks.NatMethods.2010;7:655-60.

60. StylianopoulosT,Diop-FrimpongB,MunnLL,JainRK.Diffusionanisotropyincollagengelsandtumors:theeffectoffibernetworkorientation.BiophysJ.2010a;99:3119-28.

61. StylianopoulosT,PohMZ,InsinN,BawendiMG,FukumuraD,MunnLL,JainRK.Diffusionofparticlesintheextracellularmatrix:theeffectofrepulsiveelectrostaticinteractions.BiophysJ.2010b;99:1342-9.

62. BaishJW,StylianopoulosT,LanningRM,KamounWS,FukumuraD,MunnLL,JainRK.Scalingrulesfordiffusivedrugdeliveryintumorandnormaltissues.ProcNatlAcadSciUSA.2011;108:1799-803.

63. ChengG,LiaoS,KitWongH,LacorreDA,diTomasoE,AuP,FukumuraD,JainRK,MunnLL.Engineeredbloodvesselnetworksconnecttohostvasculatureviawrapping-and-tappinganastomosis.Blood.2011;118:4740-9.


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64. JainA,MunnLL.Biomimeticpostcapillaryexpansionsforenhancingrarebloodcellseparationonamicrofluidicchip.LabChip.2011;11:2941-7.

65. LiaoS,ChengG,ConnerDA,HuangY,KucherlapatiRS,MunnLL,RuddleNH,JainRK,FukumuraD,PaderaTP.Impairedlymphaticcontractionassociatedwithimmunosuppression.ProcNatlAcadSciUSA.2011;108:18784-9.

66. PerentesJY,KirkpatrickND,NaganoS,SmithEY,ShaverCM,SgroiD,GarkavtsevI,MunnLL,JainRK,BoucherY.Cancercell-associatedMT1-MMPpromotesbloodvesselinvasionanddistantmetastasisintriple-negativemammarytumors.CancerRes.2011;71:4527-38.

67. SongJW,MunnLL.Fluidforcescontrolendothelialsprouting.ProcNatlAcadSciUSA.2011;108:15342-7.

68. HuangY,YuanJ,RighiE,KamounWS,AncukiewiczM,NezivarJ,SantosuossoM,MartinJD,MartinMR,VianelloF,LeblancP,MunnLL,HuangP,DudaDG,FukumuraD,JainRK,PoznanskyMC.Vascularnormalizingdosesofantiangiogenictreatmentreprogramtheimmunosuppressivetumormicroenvironmentandenhanceimmunotherapy.ProcNatlAcadSciUSA.2012;109:17561-6.

69. PlotkinSR,BredellaMA,CaiW,KassarjianA,HarrisGJ,EsparzaS,MerkerVL,MunnLL,MuzikanskyA,AskenaziM,NguyenR,WenzelR,MautnerVF.Quantitativeassessmentofwhole-bodytumorburdeninadultpatientswithneurofibromatosis.PLoSOne.2012;7:e35711.

70. SongJW,BazouD,MunnLL.Anastomosisofendothelialsproutsformsnewvesselsinatissueanalogueofangiogenesis.IntegrBiol(Camb).2012a;4:857-62.

71. SongJW,DaubriacJ,TseJM,BazouD,MunnLL.RhoAmediatesflow-inducedendothelialsproutingina3-Dtissueanalogueofangiogenesis.LabChip.2012b;12:5000-6.

72. StylianopoulosT,MartinJD,ChauhanVP,JainSR,Diop-FrimpongB,BardeesyN,SmithBL,FerroneCR,HornicekFJ,BoucherY,MunnLL,JainRK.Causes,consequences,andremediesforgrowth-inducedsolidstressinmurineandhumantumors.ProcNatlAcadSciUSA.2012;109:15101-8.

73. TseJM,ChengG,TyrrellJA,Wilcox-AdelmanSA,BoucherY,JainRK,MunnLL.Mechanicalcompressiondrivescancercellstowardinvasivephenotype.ProcNatlAcadSciUSA.2012;109:911-6.

74. KirkpatrickND,ChungE,CookDC,HanX,GruionuG,LiaoS,MunnLL,PaderaTP,FukumuraD,JainRK,Video-rateresonantscanningmultiphotonmicroscopy:Anemergingtechniqueforintravitalimagingofthetumormicroenvironment.IntraVital.2012;1:60-68.

75. NiemeyerE,KamounWS,HanH-S,HuangY,BhaumikJ,ChenY,GillisenM,MartinJD,RobergeS,LanningRM,CuiJ,MunnLL,NoceraDC,PaderaT,FukumuraD,JainRK,BawendiMG,DunstJ,DudaDG.Multiphotonmicroscopyandin-situlabelingtechniquesallowdetectionofendogenoushematopoeticstemcellsandmeasurementoffunctionalparametersinthestemcellniche.ONKOLOGIE.2013;36:229-230.

76. Qazi,H,PalominoR,ShiZ-D,MunnLL,TarbellJM.CancerCellGlycocalyxMediatesMechanostransductionandFlow-RegulatedInvasion.Integr.Biol.2013;5:1334-43.

77. MunnLL.Dynamicsoftissuetopologyduringcancerinvasionandmetastasis.PhysicalBiology.2013;10(6):065003(13pp).

78. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Mechanobiologicaloscillatorscontrollymphflow.ProcNatlAcadSciUSA.2015; 112:10938-43.

79. KunertC,BaishJW,LiaoS,PaderaTP,MunnLL.Nitricoxideregulateslymphaticcontractions.ProcNatlAcadSciUSA.2016.113:E106.

80. KloepperJ,RiedemannL,AmoozgarZ,SeanoG,SusekK,YuV,DalvieN,AmelungRL,DattaM,SongJW,AskoxylakisV,TaylorJW,Lu-EmersonC,BatistaA,KirkpatrickKD,JungK,SnuderlM,MuzikanskyA,StubenrauchKG,KrieterO,WakimotoH,XuL,MunnLL,DudaDG,FukumuraD,BatchelorTT,JainRK.Ang-2/VEGFbispecificantibodyreprogramsmacrophagesandresidentmicrogliatoanti-tumorphenotypeandprolongsglioblastomasurvival.ProcNatlAcadSciUSA.2016;113:4476-4481

81. GruionuGG,BazouD,MaimonN,Onita-LencoM,GruionuLG,HuangP,MunnLL.ImplantableTissueIsolationChambersforAnalyzingTumorDynamicsInVivo.LabChip.2016;16:1840-51.

82. QaziH,ShiZD,SongJW,CancelLM,HuangP,ZengY,RobergeS,MunnLL*,TarbellJM.*HeparanSulfateProteoglycansMediateRenalCarcinomaMetastasis.InternationalJournalofCancer.2016;139:2791-2801.*Equalcontributions.


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83. BazouD,NgMR,SongJW,ChinSM,MaimonN,MunnLL.Flow-inducedHDAC1phosphorylationandnuclearexportinangiogenicsprouting.ScientificReports.2016a;6:34046.

84. BazouD,MaimonN,GruionuG,MunnLL.Self-assemblyofvascularizedtissuetosupporttumorexplantsinvitro.IntegrativeBiology.2016b;8:1301-11.

85. BaishJW,KunertC,PaderaTP,MunnLL.Synchronizationandrandomtriggeringoflymphaticvesselcontractions.PLOSComputationalBiology.2016;12:e1005231.doi:10.1371/journal.pcbi.1005231.

86. NiaHT,LiuH,SeanoG,DattaM,JonesD,RahbariN,IncioJ,ChauhanVP,JungK,MartinJD,AskoxylakisV,PaderaTP,FukumuraD,BoucherY,HornicekFJ,GrodzinskyAJ,BaishJW,MunnLL,JainRK.Solidstressandelasticenergy:newmeasuresoftumormechanopathology.NatureBiomedicalEngineering.2017;1:0004.

87. GuptaN,BadeauxM,LiuY,NaxerovaK,SgroiD,MunnLL,JainRK,GarkavtsevI.Stressgranule-associatedproteinG3BP2regulatesbreasttumorinitiation.ProcNatlAcadSciUSA. 2016;114:1033-1038.doi:10.1073/pnas.1525387114.

88. KozinSV,MaimonN,WangR,GuptaN,MunnLL,JainRK,GarkavtsevI.Secretoryleukocyteproteaseinhibitor(SLPI)asapotentialtargetforinhibitingmetastasisoftriple-negativebreastcancers.Oncotarget.2017;8(65):108292–108302.

89. BazouD,MaimonN,MunnLL,GonzalezI.EffectsofLowIntensityContinuousUltrasound(LICU)onMousePancreaticTumorExplants.Appl.Sci.2017;7(12)1275;doi:10.3390/app7121275.

90. BoutaEM,BlatterC,RuggieriTA,MeijerEFJ,MunnLL,VakocBJ,PaderaTP.Lymphaticfunctionmeasurementsinfluencedbycontrastagentvolumeandbodyposition.2018;JCIInsight.3(2):e96591.

91. JonesD,MeijerEFJ,BlatterC,LiaoS,PereiraER,BoutaEM,JungK,ChinSM,HuangP,MunnLL,VakocBJ,OttoM,PaderaTP.Methicillin-resistantStaphylococcusaureuscausessustainedcollectinglymphaticvesseldysfunction.2018;ScienceTranslationalMedicine.10(424),eaam7964.OI:10.1126/scitranslmed.aam7964.

92. NiaHT,DattaM,SeanoG,Huang,P,MunnLL,JainRK.Quantifyingsolidstressandelasticenergyfromexcisedorinsitutumors.NatureProtocols.2018;13(5)1091-1105.

93. BazouD,MaimonN,GruionuG,GrahovacJ,SeanoG,LiuH,EvansCL,MunnLL.Vascularbedsmaintainpancreatictumorexplantsforexvivodrugscreening.JournalofTissueEngineeringandRegenerativeMedicine.2018;12(1):e318-e322.

94. VoutouriC,KirkpatrickND,ChungE,MpekrisF,BaishJW,MunnLL,FukumuraD,StylianopoulosT,JainRK.Experimentalandcomputationalanalysesrevealdynamicsoftumorvesselcooptionandoptimaltreatmentstrategies.ProceedingsoftheNationalAcademyofSciences2019,116:2662-2671.

95. SeanoG,Nia,HT,EmblemKE,DattaM,RenJ,KrishnanS,KloepperJ,PinhoMC,HoWW,GhoshM,AskoxylakisV,FerraroGB,RiedemannL,GerstnerER,BatchelorTT,WenPY,LinNU,GrodzinskyAJ,FukumuraD,HuangP,BaishJW,PaderaTP,MunnLL,JainRK.Solidstressinbraintumourscausesneuronallossandneurologicaldysfunctionandcanbereversedbylithium.NatureBiomedicalEngineering2019;3:230-245.

96. LiH,MeiY,MaimonN,PaderaTP,BaishJW,MunnLL.Theeffectsofvalveleafletmechanicsonlymphaticpumpingassessedusingnumericalsimulations.ScientificReports2019;9(1):10649.

97. MoranH,CancelLM,MayerMA,QaziH,MunnLL,TarbellJM.Thecancercellglycocalyxproteoglycanglypican-1mediatesinterstitialflowmechanotransductiontoenhancecellmigrationandmetastasis.Biorheology1-11,2019.

98. MpekrisF,VoutouriC,BaishJW,DudaDG,MunnLL,StylianopoulosT,JainRK.Combiningmicroenvironmentnormalizationstrategiestoimprovecancerimmunotherapy.ProceedingsoftheNationalAcademyofSciences,117:3728-3737,2020.

99. VoutouriC,KirkpatrickND,ChungE,MpekrisF,BaishJW,MunnLL,FukumuraD,StylianopoulosT,JainRK.Experimentalandcomputationalanalysesrevealdynamicsoftumorvesselcooptionandoptimaltreatmentstrategies.ProceedingsoftheNationalAcademyofSciences,116:2662-2671,2019.

100. NikmaneshiMR,FiroozabadiB,MozafariA,MunnLL.Amulti-scalemodelfordeterminingtheeffectsofpathophysiologyandmetabolicdisordersontumorgrowth.ScientificReports,10(1):3025,2020;doi:10.1038/s41598-020-59658-0.

Non-peer reviewed scientific or medical publications/materials in print or other media


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Reviews, Chapters and Editorials 1. JainRK,KoenigGC,DellianM,FukumuraD,MunnLL,MelderRJ.Leukocyte-endothelialadhesionand

angiogenesisintumors.CancerandMetastasisReviews1996;15:195-204.2. MelderRJ,KoenigG,MunnLL,JainRK.Adhesionofactivatednaturalkillercellstotumornecrosisfactor-

alpha-treatedendotheliumunderphysiologicalflowconditions.NaturalImmunity1996;15:154-163.3. JainRK,LLMunnLL,FukumuraD,MelderRJ.Invitroandinvivoquantificationofadhesionbetween

leukocytesandvascularendothelium.In:MorganJR,YarmushML,editorsMethodsinMolecularMedicineTotowa,NJ,HumanaPress,Inc1998;18:553-575.

4. JainRK,MunnLL.Leakyvessels?CallAng1!NatureMedicine2000;6:131-2.5. McDonaldD,MunnL,JainR.Vasculogenicmimicry:howconvincing,hownovel,andhowsignificant?

AmericanJournalofPathology2000;156:383-388.6. JainRK,MunnLL,FukumuraD.Transparentwindowmodelsandintravitalmicroscopy:imaginggene

expression,physiologicalfunctionanddrugdeliveryintumors.In:Teicher,B,editorTumorModelsinCancerResearchTotowa,NJ,HumanaPress,Inc2001;pp647-672.

7. JainRK,MunnLL,FukumuraD.Dissectingtumoursusingintravitalmicroscopy.NatureReviewsCancer2002;2:266-276.

8. MunnLL.Aberrantvasculararchitectureintumorsanditsimportanceindrug-basedtherapies.DrugDiscoveryToday2003;8:396-403.

9. JainRK,BrownEB,MunnLL,FukumuraD.Intravitalmicroscopyofnormalanddiseasedtissuesinmice.In:LiveCellImaging-ALaboratoryManual,GoldmanRDandSpectorDL,editors,CSHLPress,ColdSpringHarbor,NY2004;Chapter24,pp435-466.

10. BrownEB,MunnLL,FukumuraD,JainRK.Apracticalguidetoinvivoimagingoftumors.In:MPLSMLaboratoryManual,ColdSpringHarborLaboratoryPress,ColdSpringHarbor,NY2005;Chapter92,pp695-700.

11. MunnLL.Analyticalapproachestoleukocyte-endotheliuminteractions.In:MicrovascularResearch:BiologyandPathology,SheproD,editorElsevierPress,Amsterdam2005;Chapter117,pp791-794.

12. BockhornM,JainRK,MunnLL.Activeversuspassivemechanismsinmetastasis:docancercellscrawlintovessels,oraretheypushed?LancetOncol2007;8:444–48.

13. JainRK,MunnLL.Vascularnormalizationasarationaleforcombiningchemotherapywithantiangiogenesisagents.Principles&PracticeofOncology2007;21:1-7.

14. MunnLLandJainA.Designandfabricationofmicrofluidicdevicesforflow-basedseparationofbloodcells.Lab-on-a-ChipTechnology(Vol2):BiomolecularSeparationandAnalysis2009Herold,KEandRasooly,A(Eds)CaisterAcademicPress,Norfolk,UKISBN978-1-904455-47-9.

15. JainRK,MunnLL,FukumuraD.TransparentWindowModelsandIntravitalMicroscopy:ImagingGeneExpression,PhysiologicalFunctionandTherapeuticEffectsinTumors.In:TumorModelsInCancerResearch,BeverlyATeicher,edCancerDrugDiscoveryandDevelopment,2011,Part9,641-679,DOI:101007/978-1-60761-968-0_26.

16. BrownE,MunnLL,FukumuraD,JainRK.Invivoimagingoftumors.ColdSpringHarbProtoc,2010:pdbprot5452.

17. FukumuraD,DudaDG,MunnLL,JainRK.Tumormicrovasculatureandmicroenvironment:novelinsightsthroughintravitalimaginginpre-clinicalmodels.Microcirculation2010;17:206-225.

18. MunnLL,Kamoun,W,Dupin,M,TyrrellJA.Modelingstructuralandfunctionaladaptationoftumorvesselnetworksduringanti-angiogenictherapy.ModelingTumorVasculature,TrachetteJackson,ed.,SpringerScience,2011.

19. GoelS,DudaDG,XuL,MunnLL,BoucherY,FukumuraD,JainRK.Normalizationofthevasculaturefortreatmentofcancerandotherdiseases.PhysiolRev2011;91:1071-1121.

20. KozinSV,DudaDG,MunnLL,JainRK.Isvasculogenesiscrucialfortheregrowthofirradiatedtumours?NatRevCancer2011;11:532.

21. MunnLL,KamounWS.LaserScanningMethodologiesforMeasuringRBCVelocity,Flux,HematocritandShearRateinVascularNetworks.TheTextbookofAngiogenesisandLymphangiogenesis:MethodsandApplications.ZudaireEnrique,Cuttitta,F(Eds.)Springer2012,pp417-431.

22. JainRK,MunnLL,FukumuraD.Rabbitearchambers.ColdSpringHarbProtoc.2012Jul1;2012(7):813-14.doi:10.1101/pdb.prot070045.PubMedPMID:22753607.


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23. JainRK,MunnLL,FukumuraD.Cornealpocketassayinrabbits.ColdSpringHarbProtoc.2012Sep1;2012(9):1017-8.doi:10.1101/pdb.prot070052.PubMedPMID:22949714.

24. JainRK,MunnLL,FukumuraD.Mammaryfatpadchamberpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1113-4.doi:10.1101/pdb.prot071506.PubMedPMID:23028075.

25. JainRK,MunnLL,FukumuraD.Mammaryfatpadtumorpreparationinmice.ColdSpringHarbProtoc.2012Oct1;2012(10):1115-6.doi:10.1101/pdb.prot071514.PubMedPMID:23028076.

26. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemousetail.ColdSpringHarbProtoc.2012Nov1;2012(11):1177-8.doi:10.1101/pdb.prot072108.PubMedPMID:23118364.

27. JainRK,MunnLL,FukumuraD.Lymphangiographyofthemouseear.ColdSpringHarbProtoc.2012Nov1;2012(11):1179-80.doi:10.1101/pdb.prot072116.PubMedPMID:23118365.

28. JainRK,MunnLL,FukumuraD.Pancreatictumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072363.10.1101/pdb.prot072363.PubMedPMID:23209145.

29. JainRK,MunnLL,FukumuraD.Livertumorpreparationinmice.ColdSpringHarbProtoc.2012Dec1;2012(12).doi:pii:pdb.prot072371.10.1101/pdb.prot072371.PubMedPMID:23209146.

30. JainRK,MunnLL,FukumuraD.Lungwindowpreparationinmice.ColdSpringHarbProtoc.2013Jan1;2013(1).doi:pii:pdb.prot072678.10.1101/pdb.prot072678.PubMedPMID:23282642.

31. JainRK,MunnLL,FukumuraD.MeasuringInterstitialDiffusion,Convection,andBindingParametersinMouseTumors.ColdSpringHarbProtoc.2013,2013(7).

32. JainRK,MunnLL,FukumuraD.MeasuringInterstitialpHandpO2inMouseTumors.ColdSpringHarbProtoc.2013,2013(7).

33. JainRK,MunnLL,FukumuraD.MeasuringLeukocyte-EndothelialInteractionsinMice.ColdSpringHarbProtoc.2013,2013(6).

34. JainRK,MunnLL,FukumuraD.MeasuringVascularPermeabilityinMice.ColdSpringHarbProtoc.2013,2013(5).

35. JainRK,MunnLL,FukumuraD.Measuringangiogenesisandhemodynamicsinmice.ColdSpringHarbProtoc.2013,2013(4).

36. DudaDG,MunnLL,JainRK.CanWeIdentifyPredictiveBiomarkersforAntiangiogenicTherapyofCancerUsingMathematicalModeling?JNCI2013105:762-765.

37. MunnLL,KunertC,TyrrellJA.ModelingTumorBloodVesselDynamics.inMathematicalMethodsandModelsinBiomedicine--LectureNotesonMathematicalModellingintheLifeSciences,UrszulaLedzewicz,HeinzSchättler,AvnerFriedman,EugeneKashdaned.2013,pp117-147.

38. KeslerCT,LiaoS,MunnLL,PaderaTP.Lymphaticvesselsinhealthanddisease.WileyInterdisciplinaryReviews:SystemsBiologyandMedicine,2013.

39. ChauhanVP,BoucherY,FerroneCR,RobergeS,MartinJD,StylianopoulosT,BardeesyN,DePinhoRA,PaderaTP,MunnLL,JainRK.Compressionofpancreatictumorbloodvesselsbyhyaluronaniscausedbysolidstressandnotinterstitialfluidpressure.CancerCell2014,26(1):14-15.

40. MunnLL,PaderaTP.Imagingthelymphaticsystem.MicrovascularResearch2014:55-63.41. SongJW,BazouD,MunnLL.MicrofluidicModelofAngiogenicSprouting.InVascularMorphogenesis,

Springer,NY.(2015)pp243-254.42. King-,ReinhartMunnLFletcherD,GerechtS,LevineR,MallickP,McCartyO,JanmeyP, C.PhysicalSciences

andEngineeringAdvancesinLifeSciencesandOncology:AWTECGlobalAssessment.Springer,Nov19,2015403pages- .

43. MunnLL.Mechanobiologyoflymphaticcontractions.SeminarsinCell&DevelopmentalBiology.2015Elsevier,38:67-74.

44. MunnLL.FluidMechanicsandTransportinTumors.PhysicalSciencesandEngineeringAdvancesinLifeSciencesandOncology.PartoftheseriesSciencePolicyReports,2016;pp73-88.

45. PaderaTP,MeijerEFJ,MunnLL.TheLymphaticSysteminDiseaseProcessesandCancerProgression.Annu.Rev.Biomed.Eng.(2016)18:125–58.

46. MunnLL,JainRK.TheForcesofCancer.TheScientist.2016;30:52-57.47. MunnLL.CancerandInflammation.WIREsSystemsBiologyandMedicine.2017;9:e1370

doi:10.1002/wsbm.1370.


- 18 -

48. StylianopoulosT,MunnLL,JainRK.ReengineeringthePhysicalMicroenvironmentofTumorstoImproveDrugDeliveryandEfficacy:FromMathematicalModelingtoBenchtoBedside.TrendsinCancer.2018;4(4):292-319.

49. StylianopoulosT,MunnLL,JainRK.ReengineeringtheTumorVasculature:ImprovingDrugDeliveryandEfficacy.TrendsinCancer.2018;4(4):258-59.

50. MunnLL,GarkavtsevI.SLPI:anewtargetforstoppingmetastasis.Aging.2018;10(1):13–14.51. Nowak-SliwinskaP,AlitaloK,AllenE,AnisimovA,AplinAC,AuerbachR,AugustinHG,BatesDO,Van

BeijnumJR,BenderRHF,BergersG,BikfalviA,BischoffJ,BöckBC,BrooksPC,BussolinoF,CakirB,CarmelietP,CastranovaD,CimpeanAM,CleaverO,CoukosG,DavisGE,DePalmaM,DimbergA,DingsRPM,DjonovV,DudleyAC,DuftonNP,FendtS-M,FerraraN,FruttigerM,FukumuraD,GhesquièreB,GongY,GriffinRJ,HarrisAL,HughesCCW,HultgrenNW,Iruela-ArispeML,IrvingM,JainRK,KalluriR,KaluckaJ,KerbelRS,KitajewskiJ,KlaassenI,KleinmannHK,KoolwijkP,KuczynskiE,KwakBR,MarienK,Melero-MartinJM,MunnLL,NicosiaRF,NoelA,NurroJ,OlssonA-K,PetrovaTV,PietrasK,PiliR,PollardJW,PostMJ,QuaxPHA,RabinovichGA,RaicaM,RandiAM,RibattiD,RueggC,SchlingemannRO,Schulte-MerkerS,SmithLEH,SongJW,StackerSA,StalinJ,StratmanAN,VanDeVeldeM,VanHinsberghVWM,VermeulenPB,WaltenbergerJ,WeinsteinBM,XinH,Yetkin-ArikB,Yla-HerttualaS,YoderMC,GriffioenAW.Consensusguidelinesfortheuseandinterpretationofangiogenesisassays.Angiogenesis.2018;21(3):425–532.DOI:10.1007/s10456-018-9613-x.

52. NiaHT,MunnLL,JainRK,Mappingphysicaltumormicroenvironmentanddrugdelivery.ClinicalCancerResearch.2019,clincanres.3724.2018.

53. MunnLL,JainRK.Vascularregulationofanti-tumorimmunity.Science365:544-545,2019.DOI:10.1126/science.aaw7875.

54. MunnLLandNiaHT.Mechanosensingtensilesolidstresses.ProceedingsoftheNationalAcademyofSciences,116:21960-21962,2019.

Documents

Date Prepared: March 3, 2020 · 2020. 3. 3. · Curriculum Vitae Lance L. Munn, PhD - 1 - Date Prepared: March 3, 2020 Name: Lance L. Munn Education 1987 B.S. summa cum laude Chemical