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B. Mathes
Webinar, July 1 2014
DaNa2.0 – Communication platform for safety research on nanomaterials
Supported by Supported by
DECHEMA - Link between disciplines and organisations
Non-profit scientific-technological society
More than 5,800 members (including more than 650 companies)
Honorary service of far more than 1,000 high-ranking experts from research institutions and industry
About 100 working groups on scientific issues
Together with DECHEMA Ausstellungs-GmbH we are the organizers of ACHEMA, the world forum for the process industry
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2002 • Discussion in DECHEMA
workgroups
2005 • Announcement of BMBF*
funding
2006 • Project
2009 • Project
2013 • Project
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Nanomaterial safety research in Germany
*BMBF = German Federal Ministry of Education and Research
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Roots of DaNa2.0
Project NanoCare (2006 – 2009) - largest project on (human-)toxicology of nanomaterials - 11 “on the market” substances examined (19 variations)
- Public dialogue:
• Website: www.nanoobjects.info: Knowledge Base Nanoparticles (today: nanoobjects)
- SOPs (standard operation procedures) introduced
• For nanomaterials • Reproduceable • Available at www.nanoojects.info
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German national funding (2008 ff)
BMBF* funding actions (2008) - NanoCare (this time as the name
of a funding action) Human toxicology of
nanomaterials - NanoNature Nanomaterials for and
in Nature (Ecotoxicology) 18 projects and 1 accompanying: DaNa – „Database Nanomaterials“ (i.e. DaNa1.0)
*BMBF = German Federal Ministry of Education and Research
Motivation for the knowledge base
Nanotechnology in applications and consumer products
Different nanomaterials used (individual and in combinations)
When in textiles, food supplements, cosmetics:
Safety concerns
among consumers
Source: Nature
Target groups
Interested laymen
Journalists
Politicians
NGOs
Scientists but „non-toxicologists“
Complete content is available in German and English
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Picture: http://www.target-catalogue.com
Aims of DaNa/DaNa2.0
Central component of DaNa:
Communication of research on safety of nanomaterials
• Website (German/English) • Brochure, Flyer • Other Media (lectures, …)
No active research but assessment of literature and projects
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Central issues of DaNa/DaNa2.0
Impartial information on nanomaterials for objectification of public discussion
Support of German funded projects e.g. project information, SOP template, cluster meetings, …
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In-depth information on each nanomaterial
Material / Applications Exposure / Uptake / Behaviour Human toxicology / Eco-toxicology
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1 summary
2 main results known in the field
3 Link to scientific literature
Increasing depth of details
Nanotoxicology literature
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Increasing numbers of publications
# of Nanotoxicology Papers published per year. Columns for 2010 and 2011 were added by H.F.Krug and C.Steinbach. (modified from original: C.L. Haynes: The emerging field of nanotoxicology. Anal. Bioanal. Chem 398, 587-588, 2010).
Usability of nanotoxicology papers
An actual publication showed: for titaniumdioxide only ~32%, and for Zinkoxide even only 13%
of the published data are suitable for risk assesment
(Hristozov et al. 2012).
Today about 2000 publications / year => in maximum ~600 useable!
Need to be sorted out!
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Risk assessment for nanomaterials
Important • Hazard potentials and exposure
have to be determined case-bycase
• Conclusions by analogy for substance characteristics not possible
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Short risk assessment for nanomaterials TiO2 (nano) in sunscreens Positive prospects: - effective sunblock - yearly tens of thousands
skin cancer diagnoses less
Negative prospects: - permeation into the body - negative impact of nano
particles in human body
Conclusion: - better sun protection - good protection via healthy skin - more information needed for injured skin
Real: - good protection via healthy
skin
Real: - better sun protection - less use of chemical UV
block substances
Still open - epidemiology of incidence of
skin cancer by TiO2-sunscreens
Still open - research with injured skin
Contact!
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Dr. Björn Mathes DECHEMA e.V. +49 69 7564 365 [email protected] www.nanoobjects.info @nano_info