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Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
DAFTAR ISI
HALAMAN JUDUL
LEMBAR PENGESAHAN
LEMBAR PERNYATAAN ..................................................................................... i
ABSTRAK ................................................................................................................ ii
KATA PENGANTAR .............................................................................................. iv
UCAPAN TERIMA KASIH ................................................................................... v
DAFTAR ISI ............................................................................................................. vii
DAFTAR GAMBAR ................................................................................................ x
DAFTAR TABEL .................................................................................................... xi
DAFTAR LAMPIRAN ............................................................................................ xii
BAB I PENDAHULUAN ............................................................................... 1
1.1 Latar Belakang ...................................................................................... 1
1.2 Rumusan Masalah ................................................................................. 3
1.3 Tujuan Penelitian .................................................................................. 4
1.4 Batasan Masalah Penelitian .................................................................. 4
1.5 Manfaat Penelitian ................................................................................ 4
1.6 Struktur Organisasi Skripsi ................................................................... 5
BAB II TINJAUAN PUSTAKA ...................................................................... 6
2.1 Parkinson .............................................................................................. 6
2.2 Landep .................................................................................................. 8
2.3 Ekstraksi ................................................................................................ 12
2.4 Skrining Fitokimia ................................................................................ 13
2.4.1 Alkaloid ................................................................................................ 13
2.4.2 Tanin ..................................................................................................... 14
2.4.3 Saponin ................................................................................................. 14
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
2.4.4 Terpenoid .............................................................................................. 14
2.4.5 Flavonoid .............................................................................................. 16
2.5 Spektoskopi Fourier Transform Infra Red (FTIR) ............................... 16
2.6 Uji Farmakologi .................................................................................... 17
2.6.1 Hewan Uji ............................................................................................. 17
2.6.2 Pengujian Toksisitas ............................................................................. 18
2.6.3 Katalepsi ............................................................................................... 19
BAB III METODE PENELITIAN .................................................................. 22
3.1 Sampel dan Lokasi Penelitian ............................................................... 22
3.2 Alat dan Bahan Penelitian ..................................................................... 22
3.2.1 Alat ........................................................................................................ 22
3.2.2 Bahan .................................................................................................... 22
3.3 Metode Penelitian ................................................................................. 23
3.3.1 Proses Ekstraksi .................................................................................... 24
3.3.2 Skrining Fitokimia ................................................................................ 24
3.3.3 Karakterisasi Gugus Fungsi .................................................................. 25
3.3.4 Uji Farmakologi Antiparkinson ............................................................ 25
3.3.4.1 Preparasi Hewan Uji ............................................................................. 25
3.3.4.2 Preparasi Pemberian Dosis ................................................................... 26
3.3.4.3 Pengujian Toksisitas ............................................................................. 27
3.3.4.4 Pengujian Katalepsi .............................................................................. 27
3.3.4.5 Analisis Data ......................................................................................... 28
BAB IV HASIL DAN PEMBAHASAN ........................................................... 29
4.1 Hasil Ekstraksi Akar Landep ................................................................ 29
4.2 Hasil Skrining Fitokimia ....................................................................... 30
4.3 Hasil Karakterisasi FTIR ...................................................................... 31
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
4.2 Hasil Uji Toksisitas Akut ...................................................................... 32
4.1 Hasil Uji Katalepsi ................................................................................ 33
BAB V KESIMPULAN DAN SARAN ........................................................... 39
5.1 Kesimpulan ........................................................................................... 39
5.2 Saran ..................................................................................................... 36
DAFTAR PUSTAKA ............................................................................................... 40
LAMPIRAN .............................................................................................................. 43
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
DAFTAR GAMBAR
Gambar 2.1. Struktur Dopamin 6
Gambar 2.2. a. Struktur Levodopa 7
b. Struktur Amantadin 7
c. Struktur Karbidopa 7
d. Struktur Enthocapone 7
Gambar 2.3. Landep 8
Gambar 2.4. a. Daun Landep 9
b. Akar Landep 9
c. Batang Landep 9
Gambar 2.5. Struktur senyawa yang terkandung dalam landep 10
Gambar 2.6. Reaksi uji fitokimia alkaloid 14
Gambar 2.7. Reaksi uji fitokimia triterpenoid 15
Gambar 2.8. Reaksi uji fitokimia flavonoid 16
Gambar 2.9. Struktur Haloperidol 20
Gambar 3.1. Bagan Alir Penelitian 23
Gambar 3.2. Skema Pengujian Katalepsi 28
Gambar 4.1. Akar landep 29
Gambar 4.2. Ekstrak Kering Akar Landep 30
Gambar 4.3. Spektrum IR Akar Landep 31
Gambar 4.4. Pengujian toksisitas akut 33
Gambar 4.5. a. Pengelompokan Mencit 34
b. Induksi Haloperidol 34
c. Pengujian Katalepsi 34
Gambar 4.6. Grafik Uji Katalepsi Ekstrak Landep Dosis 36
200 mg/kg dan 400 mg/kg
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
DAFTAR TABEL
Tabel 2.1. Klasifikasi ilmiah landep (Barleria prionitis) 8
Tabel 2.2. Klasifikasi Mencit 18
Tabel 2.3. Tingkat Toksisitas dosis suatu bahan 19
Tabel 4.1. Hasil uji Skrining Fitokimia ekstrak akar landep 30
Tabel 4.2. Hasil pengujian tingkat toksisitas akut 33
Tabel 4.3. Data Hasil uji katalepsi 35
Tabel 4.4. Hasil Uji One way ANOVA Uji Dunnet Ekstrak Akar 37
Landep Dosis 200 mg/kg Berat Badan dan Dosis 400 mg/kg
Berat Badan Terhadap Pengujian Katalepsi.
Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu
DAFTAR LAMPIRAN
Lampiran 1. Perhitungan Persentase Ekstrak dalam Akar landep. 43
Lampiran 2. Perhitungan pembuatan sediaan haloperidol. 44
Lampiran 3. Konversi Perhitungan dosis untuk berbagai jenis hewan 45
dan manusia.
Lampiran 4. Data berat badan mencit pada pengujian tingkat 46
toksisitas akut
Lampiran 5. Data berat badan mencit pada pengujian katalepsi 47
Lampiran 6. Prosedur pengujian katalepsi 48
Lampiran 7. Tes Kenormalan 49
Lampiran 8. Data hasil uji statistik 50
Lampiran 9. Foto-foto kegiatan 54