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DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

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Page 1: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

DAFTAR ISI

HALAMAN JUDUL

LEMBAR PENGESAHAN

LEMBAR PERNYATAAN ..................................................................................... i

ABSTRAK ................................................................................................................ ii

KATA PENGANTAR .............................................................................................. iv

UCAPAN TERIMA KASIH ................................................................................... v

DAFTAR ISI ............................................................................................................. vii

DAFTAR GAMBAR ................................................................................................ x

DAFTAR TABEL .................................................................................................... xi

DAFTAR LAMPIRAN ............................................................................................ xii

BAB I PENDAHULUAN ............................................................................... 1

1.1 Latar Belakang ...................................................................................... 1

1.2 Rumusan Masalah ................................................................................. 3

1.3 Tujuan Penelitian .................................................................................. 4

1.4 Batasan Masalah Penelitian .................................................................. 4

1.5 Manfaat Penelitian ................................................................................ 4

1.6 Struktur Organisasi Skripsi ................................................................... 5

BAB II TINJAUAN PUSTAKA ...................................................................... 6

2.1 Parkinson .............................................................................................. 6

2.2 Landep .................................................................................................. 8

2.3 Ekstraksi ................................................................................................ 12

2.4 Skrining Fitokimia ................................................................................ 13

2.4.1 Alkaloid ................................................................................................ 13

2.4.2 Tanin ..................................................................................................... 14

2.4.3 Saponin ................................................................................................. 14

Page 2: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

2.4.4 Terpenoid .............................................................................................. 14

2.4.5 Flavonoid .............................................................................................. 16

2.5 Spektoskopi Fourier Transform Infra Red (FTIR) ............................... 16

2.6 Uji Farmakologi .................................................................................... 17

2.6.1 Hewan Uji ............................................................................................. 17

2.6.2 Pengujian Toksisitas ............................................................................. 18

2.6.3 Katalepsi ............................................................................................... 19

BAB III METODE PENELITIAN .................................................................. 22

3.1 Sampel dan Lokasi Penelitian ............................................................... 22

3.2 Alat dan Bahan Penelitian ..................................................................... 22

3.2.1 Alat ........................................................................................................ 22

3.2.2 Bahan .................................................................................................... 22

3.3 Metode Penelitian ................................................................................. 23

3.3.1 Proses Ekstraksi .................................................................................... 24

3.3.2 Skrining Fitokimia ................................................................................ 24

3.3.3 Karakterisasi Gugus Fungsi .................................................................. 25

3.3.4 Uji Farmakologi Antiparkinson ............................................................ 25

3.3.4.1 Preparasi Hewan Uji ............................................................................. 25

3.3.4.2 Preparasi Pemberian Dosis ................................................................... 26

3.3.4.3 Pengujian Toksisitas ............................................................................. 27

3.3.4.4 Pengujian Katalepsi .............................................................................. 27

3.3.4.5 Analisis Data ......................................................................................... 28

BAB IV HASIL DAN PEMBAHASAN ........................................................... 29

4.1 Hasil Ekstraksi Akar Landep ................................................................ 29

4.2 Hasil Skrining Fitokimia ....................................................................... 30

4.3 Hasil Karakterisasi FTIR ...................................................................... 31

Page 3: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

4.2 Hasil Uji Toksisitas Akut ...................................................................... 32

4.1 Hasil Uji Katalepsi ................................................................................ 33

BAB V KESIMPULAN DAN SARAN ........................................................... 39

5.1 Kesimpulan ........................................................................................... 39

5.2 Saran ..................................................................................................... 36

DAFTAR PUSTAKA ............................................................................................... 40

LAMPIRAN .............................................................................................................. 43

Page 4: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

DAFTAR GAMBAR

Gambar 2.1. Struktur Dopamin 6

Gambar 2.2. a. Struktur Levodopa 7

b. Struktur Amantadin 7

c. Struktur Karbidopa 7

d. Struktur Enthocapone 7

Gambar 2.3. Landep 8

Gambar 2.4. a. Daun Landep 9

b. Akar Landep 9

c. Batang Landep 9

Gambar 2.5. Struktur senyawa yang terkandung dalam landep 10

Gambar 2.6. Reaksi uji fitokimia alkaloid 14

Gambar 2.7. Reaksi uji fitokimia triterpenoid 15

Gambar 2.8. Reaksi uji fitokimia flavonoid 16

Gambar 2.9. Struktur Haloperidol 20

Gambar 3.1. Bagan Alir Penelitian 23

Gambar 3.2. Skema Pengujian Katalepsi 28

Gambar 4.1. Akar landep 29

Gambar 4.2. Ekstrak Kering Akar Landep 30

Gambar 4.3. Spektrum IR Akar Landep 31

Gambar 4.4. Pengujian toksisitas akut 33

Gambar 4.5. a. Pengelompokan Mencit 34

b. Induksi Haloperidol 34

c. Pengujian Katalepsi 34

Gambar 4.6. Grafik Uji Katalepsi Ekstrak Landep Dosis 36

200 mg/kg dan 400 mg/kg

Page 5: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

Page 6: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

DAFTAR TABEL

Tabel 2.1. Klasifikasi ilmiah landep (Barleria prionitis) 8

Tabel 2.2. Klasifikasi Mencit 18

Tabel 2.3. Tingkat Toksisitas dosis suatu bahan 19

Tabel 4.1. Hasil uji Skrining Fitokimia ekstrak akar landep 30

Tabel 4.2. Hasil pengujian tingkat toksisitas akut 33

Tabel 4.3. Data Hasil uji katalepsi 35

Tabel 4.4. Hasil Uji One way ANOVA Uji Dunnet Ekstrak Akar 37

Landep Dosis 200 mg/kg Berat Badan dan Dosis 400 mg/kg

Berat Badan Terhadap Pengujian Katalepsi.

Page 7: DAFTAR ISI HALAMAN JUDUL LEMBAR PENGESAHAN KATA PENGANTAR ...repository.upi.edu/12778/2/S_KIM_1005280_Table_of_content.pdfKATA PENGANTAR ... 1 1.1 Latar Belakang ... Uji Farmakologi

Ari Ardianti, 2014 Uji Farmakologi Ekstrak Akar Landep (Barleria Prionitis Linn) Asal Indonesia Sebagai Antiparkinson Universitas Pendidikan Indonesia | repository.upi.edu | perpustakaan.upi.edu

DAFTAR LAMPIRAN

Lampiran 1. Perhitungan Persentase Ekstrak dalam Akar landep. 43

Lampiran 2. Perhitungan pembuatan sediaan haloperidol. 44

Lampiran 3. Konversi Perhitungan dosis untuk berbagai jenis hewan 45

dan manusia.

Lampiran 4. Data berat badan mencit pada pengujian tingkat 46

toksisitas akut

Lampiran 5. Data berat badan mencit pada pengujian katalepsi 47

Lampiran 6. Prosedur pengujian katalepsi 48

Lampiran 7. Tes Kenormalan 49

Lampiran 8. Data hasil uji statistik 50

Lampiran 9. Foto-foto kegiatan 54