CURRICULUM VITAE

Margaret Sällberg Chen, DDS, PhD, Associate ProfessorSenior Lecturer, Research Group Leader (Tenure)Director Doctoral Education and International Affairs

Department of Dental Medicine, Karolinska InstitutetPhone +46-(0)8-52488125 | Email: Margaret.Chen@ki.se Homepage; http://ki.se/people/marche 

PROFESSIONAL QUALIFICATIONS Associate Professor (docent), Karolinska InstitutetPhD in Oral Microbiology and Virology, Karolinska InstitutetSwedish Dentist LicenseDDS, Karolinska Institutet

PREVIOUS APPOINTMENTS Acting Head of Unit, Department of Dental Medicine, KIResearch Theme Leader Infection, Inflammation and Immunology, DENTMED, KIResearch Scientist, Public Health Agency of Sweden Assistant Professor, Dept of Infection, Microbiology, Pathology and Immunology, KIPostdoc Fellow, Prof P. Liljeström´s Laboratory, MTC, KIPostdoc Fellow, Dr D.R. Milich´s Laboratory, The Scripps Research Institute, San Diego, USAGeneral Dental Practitioner, Jönköping, Sweden

SELECTED ACADEMIC MERITS 2019-present, Full Member Cancer Research Reference Group of KI2018-present, Guest Professor, Shanghai Tongji University, Shanghai, China 2020-2023 Expert Reviewer International Liver Congress Scientific Committee, The European Association for the Study of the Liver (EASL)2016, EMBO leadership qualification: The art of leadership, European Molecular Biology Organisation2015, Cancerfonden Travel Award. Visiting Scientist at Dr. Steven Rosenberg´s Laboratory, National Cancer Institute, NIH, Bethesda, Maryland, USA, 2014-present, Editorial Board Member, Scientific Reports, Nature Publishing Group2013, Guest of Honor, Life Science Women in Leadership, Harvard Undergraduate Women Business program

SUPERVISION OF DOCTORATES AND POSTDOCTORAL FELLOWS (* PRESENT)* Main supervisor of Haleh Davian, PhD, Postdoc. Dr. Davanian holds a PhD degree in RNA sequencing.* Main supervisor of Giorgio Gabarrini, PhD, Postdoc, Dr holds a PhD degree in oral microbiology* Main supervisor of Michal Sobkowiak, PhD, Postdoc, Dr holds a PhD degree in mucosal immunology* Main supervisor of 4 PhD students: Hassan Alkharaan (DDS), Katie Healy (MSc), Liyan Lu (DDS), Rahul Harshad Nagadia (DDS, MD, oral surgeon). * Co-supervisor of 3 PhD students: Asif Halimi (MD, pancreas surgeon), Zeeshan Ateeb (MD), Yanhong Su (MD). Main supervisor of Anna Pasetto, PhD thesis defended on 2012. Main supervisor of postdoc fellows: Anila Yasmeen, Balasiddaiah Anangi. Co-supervisor of Michal Sobkowiak PhD defence 2019, Haleh Davanian, PhD defenced 2014, Tanja Näslund PhD defence 2009

BIBLIOMETRIC ANALYSIS (Web of Science by Nov 2019)Sum of the Times Cited: 2552. Average citations per publication: 40.17 H-index: 22

RESEARCH GRANTS attributed past 10 years Total 22,5 million SEK as PI and co-PICancerfonden CAN 2016/731, CAN 2013/833 2007-16, 2017-19, 2020-2022 PI, 6,900,000 SEKJohnson & Johnson Innovation Award 2017-2018 Co-PI, $432,000 USDKI/SLL Strategiska Odontologisk Forskningsfond 2014-2022 PI, 5,310,000 SEKKI/SLL Strategiska Odontologisk Forskningsfond 2014-2016 Co-PI, 1,260,000 SEKKI KID faculty funds 2017- 2020 PI, 1,280,000 SEKVR Medical Research Council 2009-2011 PI, 1,250,000 SEKRuth and Richard Julins funds, Anna Cederbergs stiftelsen PI, 328 000 SEKVR/KI Odontologiska Forskarskola 2009-2014 Co-PI, 1,280,000 SEKRadiumhemmets forskningsfond 2020-2021 PI, 400 000 SEKALF Stockholm 2018 Co-PI, 300 000 SEK

PROFESSIONAL MEMBERSHIPS AND COMMISSIONS OF TRUSTMember, Steering Group, KI-NTU-NDCS Singapore Conference in Oral Health Research, Singapore, 2019

Member ABC Academic Programme Group of Paedatric Dentistry, KI/SLL, 2016-presentMember, International Association of Dental Research (IADR), Oral Medicine Section, 2019-presentMember, The European Association for the Study of the Liver (EASL), 2017-presentMember, American Association for the Study of Liver Diseases (AASLD), 2017-presentMember, Dissertation Committee, Board of Doctoral Education, KI, 2015 – 2019 Organiser, KI-NTU-NDCS Singapore Joint Conference, Stockholm, 2017Organiser, Swedish Cariology Association, Annual Meeting, Stockholm, 2016

FORMAL COURSES TAUGHT AT UNIVERSITY LEVELCourse director “Exam Work in Oral Sciences”, 30 credits, Dentistry Programme KI, 2015 – presentCourse director “Medical Microbiology, 30 credits, Medical Programme KI, 2002Curriculum Director, Year 2, Dentistry Programme KI, 2014- presentClinical instructor for Dentistry Students (Year 3-5), Dentistry Programme KI, 2008-2017

SELECTED PUBLICATIONS Soon CF, Behrendt P, Manns MP, Wedemeyer H, Sällberg Chen M#, Cornberg M#. Defining CD8+ T cell Repertoires Against Hepatitis E Virus (HEV) for Therapeutic Regeneration of T cells Against Chronic Hepatitis E. Journal of Hepatology. 2019 Jun 14. pii: S0168-8278(19)30349-6. #Both authors contributed equally.

Gaiser GA, Halimi A, Alkharaan H, Lu L, Davanian H, Healy K, Hugerth LW, Ateeb Z, Valente R, Férnandez Moro C, Del Chiaro M, Sällberg Chen M. Enrichment of Oral Microbiota in Early Cystic Precursors to Invasive Pancreatic Cancer. GUT. 2019 Mar 14. pii: gutjnl-2018-317458.

Gaiser GA, Pessia A, Ateeb Z, Davanian H, Fernández Moro C, Alkharaan H, Healy K, Velagapudi V, Sällberg Chen M#, Del Chiaro M#. Integrated Metabolome and Lipidome of Liquid Biopsies to Discriminate Severity of Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas. Scientific Reports. 2019 Jul 15;9(1):10208. #Both authors contributed equally.

Davanian H, Gaiser GA, Silfverberg M, Hugerth LW, Sobkowiak MJ, Sandberg JK, Näsman P, Karlsson J, Jansson L, Engstrand L and Sällberg Chen M. Tissue MAIT Cell Infiltration and Riboflavin Producing Microbiome in Persistent Apical Periodontitis. Int J Oral Sci. 2019 May 9;11(2):16.

Koh S, Tham CY, Ceccarello E, Chia A, Yang N, Chen M, Khakpoor A, Pavesi A, Tan AT and Bertoletti A. Engineering non-cytolytic T cells activating the APOBEC3 innate antiviral pathway. Gastroenterology. 2018 Mar 14. pii: S0016-5085(18)30321-4. doi: 10.1053/j.gastro.2018.03.027.

Ahlen G, Frelin F, Brenndörfer E, Brass A, Weiland O, Chen M, and M Sällberg. Containing “The Great Houdini” of viruses: Combining directly acting antivirals with the host immune response for the treatment of chronic hepatitis C. Drug Resistance Updates. 2013 Aug. doi:pii: S1368-7646(13)00025-3.

Schulz O, Diebold SS, Chen M, Näslund T, Nolte M, Alexopoulou L, Azuma YT Flavell R, Liljeström P, and C Reis e Sousa. Toll-like receptor 3 mediates dendritic cell activation by virus-infected cells and promotes cross-priming in vivo. Nature. 2005. 433:887.

Chen M, Billaud JM, Sällberg M, Guidotti L, Chisari F, Jones J, Hughes J and Milich DR. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci U S A. 2004. 12;101(41):14913-8.

Chen M, Sällberg M, Sönnerborg A, Weiland O, Mattsson L, Jin L, Birkett A, Peterson D, Milich D.R. Limited immunogenicity of the hepatitis C virus proteins. Gastroenterology. 1999. 116(1):135-143.

Milich DR, Chen M, Schödel F, Peterson D, Jones J, Hughes J. Role of B cells in antigen presentation of the hepatitis B core. Proc Natl Acad Sci U S A. 1997. 94(26): 14648-14653.

A full list of publications is available at: http://ki.se/people/marche 

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