1

CURRICULUM VITAE

OF

BRIJ B. SINGH, Ph.D

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PERSONAL DATA

Name: Brij B. Singh, Ph.D.

Present Position: Chester Fritz Distinguished Professor and Assistant Dean for Research

Work Address: Department of Biomedical Sciences,

School of Medicine and Health Sciences The University of North Dakota, 1301 N Columbia Road, Room W221. Grand Forks, ND 58203 Phone 701-777-0834 Fax 701-777-2382 Email: brij.singh@med.und.edu

Web page: https://und.edu/faculty/brij.singh

Home Address: 735, River Park PL SE Oronoco, MN 55960 Phone: 701-775-8219: Cell: 701- 330-8575

Nationality: US Citizen

EDUCATION

Undergraduate and Masters • B.S. in Biology, with minor in Chemistry, Aligarh University (AMU), Aligarh, India in 1991. • M.S. in Biotechnology, Aligarh University (AMU), Aligarh, India in 1993.

Graduate

• Post-graduate diploma in Human Resource Management, Indira Gandhi Open National University, India in 1995.

• Ph.D. in Biochemistry, Bhopal University India and the University of Bonn Germany in 1997. Advisor: Dr. P.S Bisen. Thesis title: Calcium and Calmodulin regulation in Cyanobacteria. Awarded DAAD fellowship (sandwich model) to carry out my Ph.D. research in Germany. • Graduate Research Assistant from 1993-1996, Institute of Biotechnology, Bhopal University,

Bhopal, India • Research Fellow (DAAD Fellow) from 1996-1998, Molecular Biochemistry Section, University of

Bonn, Bonn, Germany

Postgraduate • Postdoctoral fellow from 1998-1999, Department of Pharmacology and Therapeutics, Medical

College of Wisconsin, Milwaukee, WI. • Research Fellow from 1999-2002, Gene Therapy and Therapeutics Branch, National Institute of

Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD.

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PROFESSIONAL AND ADMINISTRATIVE EXPERIENCE: • Assistant Dean for Research, School of Medicine and Health Sciences 2016-present • Program Director Host-pathogen interactions, since 2015. Professor with Tenure, Department

of Biomedical Sciences (previously Department of Biochemistry & Molecular Biology), School of Medicine, University of North Dakota, Grand Forks, ND 2011-.

• Associate Professor with Tenure, Department of Biochemistry & Molecular Biology, School of Medicine, University of North Dakota, ND 2007-2011.

• Assistant Professor, Department of Biochemistry & Molecular Biology, School of Medicine, University of North Dakota, ND Feb 2003-2007.

• April 1999- Jan 2003: Research Fellow, Gene Therapy & Therapeutics Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD.

• August 1998 – March 1999 Research Fellow Department of Pharmacology and Therapeutics, Medical College of Wisconsin, Milwaukee, WI.

• September 1996 – July 1998 DAAD Fellow, laboratory of Molecular Biochemistry, University of Bonn, Germany.

SCHOLARSHIP AND RESEARCH ACTIVITIES Current Grant Support

Title: TRPC1 calcium, and exocrine function Source: NIH, NIDCR R01 DE017102 Amount: $1,774,102 Award period 07/01/2005-09/30/2020 Role: PI: (Brij Singh) Co-PI None The long term goal of this project is to identify and elucidate the mechanism of the role of TRPC1 function in salivary glands secretion and regulation. Title: Center for Excellence In-Host Pathogen Interactions Source: NIH, NIGMS 1P20GM113123 Amount: $10,795,000.00 Award period 05/15/2016-05/30/2021 Role: PI: (Brij Singh) Co-PI Malak Kotb and David Bradley The long term goal of this program project grant (COBRE) is to establish a center for host pathogen interaction. Title: Galectins as novel alarmins in salivary gland inflammation Source: NIH, NIDCR 1R21DE024300-01A1 Amount: $385,000.00 Award period 07/01/2015-06/30/2017 Role: PI: (Brij Singh) Co-PI Bibhuti Mishra The long term goal of this project is to identify the role of alarmins in regulating inflammation. Title: Environmental toxins and stem cell epigenetic remodeling Source: NIH, NIHES R01 ES022030-01 Amount: $1,552,500 Award period 09/01/2012-08/30/2017 Role: Co-I: (Brij Singh) PI Joyce Ohm The long term goal of this project is to identify the relationship between environmental toxins and epigenetic regulation in Parkinson’s disease. Title: Lung innate immunity against bacterial infection Source: NIH, NIAID 1R01AI109317-01A1 Amount: $1,770,000 Award period 06/01/2014 – 05/31/2019 Role: Co-I: (Brij Singh) PI Min Wu

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The goal of this project is to determine the role of ATG-7-mediated autophagy in protection against gram-negative bacteria in bacterial clearance by alveolar macrophages.

Grants Pending • PI: Brij B Singh, NIH R01 (DE022765) grant December 2016- November 2021.

Epigenetic regulation in Sjögerns syndrome. Total cost ($ 1,800,500.00). The long-term goal of this project is to elucidate the role of epigenetic regulations in the onset of Sjogren’s syndrome (scored at 12 percentile and is planned to be funded in May 2017).

• PI: Brij Singh; VA Merit award grant (1 I01 RX002110-01A2) December 2016- November 2020. TRPC1-depedent calcium entry inhibits excitotoxicity in DA neurons. Direct cost ($1,100,000.00).The long-term goal of this project is to identify and elucidate the role of calcium in regulating cell death. Scored at 17 percentile and pending.

• PI: Brij B Singh; NIH R01 (NS083707) grant June 2015- May 2020. Loss of TRPC1-mediated SOCE induces ER stress. Total cost ($1,725,000.00).The long-term goal of this project is to identify and elucidate the mechanism of the neuroprotective role of TRPC1. Impact score 36, in the process of revising the grant as has some overlap with the VA merit grant.

• MPI: Brij B Singh and Bidhan Bandyopadhyay; VA Small grant SPiRE (1 I21 RX002055-01A1) 09/01/16 - 08/30/18. TRPC3, and chronic TBI-induced hypopituitarism. Total cost ($205,000.00).This study will investigate the role of TRPC3 in alleviating the neurobehavioral abnormalities in chronic TBI. Scored at 255 and pending council review)

• PI: Brij B Singh, collaborator YS Prakash, and Robert Vassallo (at Mayo clinic) NIH R01 grant Dec 2016- Jan 2021. Electronic cigarette and glandular dysfunction. Total cost ($ 2,556,823.00). The long-term goal of this project is to elucidate the role of e-cigarette and cigarette smoke on oral function.

Grants Completed • PI: Brij B Singh; North Dakota BRIN Faculty Start-Up Grant. “Role of TRP proteins in

calcium signaling” Jan1 2003- Aug 2003 Total Cost $100,000. • PI: Brij B Singh. Infrastructure Improvement Program (IIP) - Equipment Grants ND-

EPSCoR “Calcium imaging facility at UND” Total Cost $ 89,218. • PI: Brij B Singh; North Dakota EPSCoR Seed grant. “TRPC1 regulation and function”

June 1 2003-May 2005 $ 37,500. • PI: Brij B Singh: University Seed money grant. “Defining the role of Transient

Receptor Potential Protein-3 (TRPC3) in brain & primary neurons” 2004-2006 Total cost $ 40,000.

• PI: Brij B Singh: COBRE Research Grant. “TRPC1, apoptosis and Parkinson’s disease” January 2005- June 2007 $ 80,000.

• PI: Brij B Singh: ND-EPSCoR doctoral Dissertation assistantship (student fellowship for Sunitha Bollimuntha). “TRPC3 and Neurosecretion” August 2006- July 2008 $ 32,000.

• PI: Brij B Singh: ND-EPSCoR doctoral Dissertation assistantship (student fellowship for Biswaranjan Pani). “TRPC1, lipid rafts, and salivary function” August 2008- July 2009 $ 20,000.

• PI: Van Doze, Co-PI Brij B Singh; NSF MRI grant September 2009- August 2012. Acquisition of a stereology System for Research and Education in Cell Signaling Total cost $224,840.00).The long-term goal of this project is to obtain a stereology system here at UND.

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• PI: Brij B Singh: ND-EPSCoR doctoral Dissertation assistantship (student fellowship for Jordan Karlstad). “STIM1 regulation and function” August 2008- July 2010 $ 32,000.

• PI: Brij B Singh: NSF regular grants (MCB-0548733) Title: Structure-Function investigation and regulation of TRPC1. Award period 06/01/06-05/31/2010, $404,646. The long-term goal of this project is to identify the domains critical for TRPC1 regulation and function.

• PI: Brij B Singh: RO1 DE017102 NIH, NIDCR Title: TRPC1 calcium, and saliva secretion. Award period 05/01/06-03/31/2011, $1, 223,600.00. The long-term goal of this project is to identify the role of TRPC1 and calcium in salivary secretion.

• Project leader Brij B Singh (P20 RR017699) Title: Neurodegenerative Diseases and Signaling Award period 08/01/2007-07/31/2012 Total Amount: $10,092,241.00 (NIH, NCRR (COBRE) Project title: TRPC1, Calcium, and Parkinson’s disease (cost for this project $1,223,600). The long-term goal of this project is to elucidate the role and the mechanism of TRPC1 channels in Parkinson’s disease.

• PI (Brij Singh, Joyce Ohm, Min Wu and Jamie Foster) Title: Molecular mechanisms of neurodegenerative disorders: a role of environmentally-induced oxidative stress in Parkinson’s disease. Award period 08/01/10-07/31/2012 Amount: $100,000 (COBRE, Pilot Project). The long-term goal of this project is to identify the epigenetic regulations in Parkinson’s samples.

• PI: (Brij Singh) Title: Testing of neuroprotective effects of a novel compound using PD models. Award period 04/01/10-03/30/2013 Amount: $32,000. Source: Rexahn Pharmaceuticals. The long-term goal of this project is to evaluate the neuroprotective role of Rx10010 in neurodegenerative diseases.

• Title: STAT3 and its Acetylation in Acute Lung Injury. Award period 08/01/08-05/31/2014 Amount: $1,653,000 (1R01HL092905-01), Source: NIH, NHLB. Role: Co-PI, PI: (Hongwei Gao).The long-term goal of this project is to identify the role of STAT3 in regulating cytokine expression.

• PI: (Brij Singh) Title: Ceramide membrane microdomains regulate cytokine secretion. Award period 05/15/2012-04/30/2015. Amount: $138,000, Source: NIH, NIAID 1R03AI097532-01A1. The long-term goal of this project is to evaluate the role of lipid rafts in cytokine secretion.

• Title: Acquisition of a TIRF/Widefield fluorescence microscope. Source: NIH NCRR. Award period 08/01/13-07/31/14. Amount: $341,070 (direct) (Grove) (Co-PI: Singh, Vaughan, Geiger, Ghribi). The goal of this project is to attain a TIRF microscope for the UND Imaging Center.

• PI: Brij B Singh: RO1 DE017102 NIH, NIDCR Title: TRPC1 calcium, and saliva secretion. Award period 05/01/11-08/31/2015, $1,773,600.00. The long-term goal of this project is to identify the role of TRPC1 and calcium in salivary secretion.

• Title: Role of STIM1 in E.coli Pneumonia sepsis. Source: NIH, NIAID R21AI110882-01A1.Amount: $456,359 (subcontract 70,000). Award period 12/01/2015-11/30/2017.Role: Co-I: (Brij Singh) PI: (Hongwei Gao). The long-term goal of this project is to evaluate the role of STIM1 and calcium entry in sepsis.

HONORS, SPECIAL RECOGNITIONS, AND AWARDS

• Awarded Chester Fritz Distinguished Professorship (the highest award that is bestowed on UND

faculty) in 2016. • Received 2016 UND Foundation/Thomas J. Clifford Faculty Achievement Award for Excellence in

Research.

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• Received a five-year renewal of the NIH R01 grant “TRPC1, Calcium, and function in 2015”. • Received North Dakota Spirit Award at UND Founders day in 2012. • Received a five-year renewal of the NIH R01 grant “TRPC1, Calcium, and Salivary gland

Dysfunction in 2011”. • Received Dean H David Wilson Academic Award in Neurosciences at School of Medicine and

Health Sciences in 2011. • Received School of Medicine and Health Sciences Grant Achievement Award in 2010. • Received North Dakota Spirit Award at UND Founders day in 2009. • Received funding for a five-year NIH program project grant (COBRE) “Neurodegenerative diseases

and signaling” in 2008. • Received a five-year NIH R01 award “Salivary gland Dysfunction: Role of TRPC1 protein”. • Received a three-year NSF award “Structure-Function investigation and regulation of TRPC1

protein”. • Received ND-EPSCoR Doctoral dissertation award” TRPC3 and Neurosecretion”. • Received a two-year COBRE pilot grant “TRPC1 and PD”. • Received ND-EPSCoR Infrastructure Improvement Equipment Grants “Calcium imaging facility at

UND” • Received ND-EPSCoR Seed grant. “TRPC1 regulation and function • Received Faculty Start-Up Grant. “TRP proteins its regulation and function” at School of Medicine

and Health Sciences, University of North Dakota. • Received ND-BRIN award to define the functional role of TRPC1 in salivary gland physiology. • Received a Fellowship award in recognition of outstanding research in oral and craniofacial health

and disease in 2003. • Received competitive Travel Award for the year 2002 to present my research at a scientific

meeting. This award was in recognition for outstanding research important for NIH mission. • Received competitive Travel Award for the year 2000 to present my research at a scientific

meeting. This award was in recognition for outstanding research important for NIH mission. • Fellow 1999-2003 at Gene Therapy and Therapeutics Branch, NIDCR, NIH USA. • Post Doctoral Fellow 1998-99 Department of Pharmacology Wisconsin USA. • DAAD Fellow 1996-98 Botanisches Institut der Universitat Bonn, Germany. • National Educational Test 1993 (June) CSIR & UGC, Ministry of HRD, Govt. of India. • GATE 1993 Conducted by IIT on behalf of Dept. of Education HRD with 98.62 percentile. • Received Department of Biotechnology fellowship for the session 1991-93. • Received merit scholarship in B.Sc. (Hons) at Aligarh University Aligarh for the session 1988-91. • Vice Chancellor's award for the year 1988-89 at Aligarh University Aligarh.

PROFESSIONAL MEMBERSHIPS

• New York Academy of Sciences 2002-2010 • North Dakota Academy of Sciences 2003-present • American Society of Biochemistry and Molecular Biology 2003- present • American Society of Advancement of Sciences 2003-present • American Society of Cell Biology 2005- present • Sigma Xi 2003- present.

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REVIEW AND REFEREE WORK

Editorial board member • Academic Editor “Scientific Reports” (Nature Publishing Group) (handling editor) • Academic Editor “PLOS ONE” (handling editor) • Editorial Board “Journal of Dental Research” (handling editor) • Editorial Board “New Journal of Science” (handling editor) • Senior Editorial Board “International Journal of Biochemistry and Molecular Biology” • Editorial Board “Channels” (Taylor and Francis Publishing) • Editorial Board “Journal of Membrane Science & Technology” (OMICS Publishing) • Editorial Board “Dataset Papers in Biology” • Editorial Board “World Journal of Pharmacology” • Editorial Board “Transcriptomics (OMICS Publishing) • Editorial Board “Journal of Neurorestoratology” • Member Reviewers Board “Journal of Pediatric Biochemistry”

Scientific Activities (Journal reviewer)

• Reviewer for Journal of Cell Biology (Rockefeller press) • Reviewer for Proceedings National Academy of Sciences (PNAS) • Reviewer for Chemistry and Biology (Cell press) • Reviewer for FASEB Journal • Reviewer for Journal of Immunology • Reviewer for Journal of Biological Chemistry • Reviewer for Journal of Cellular Physiology • Reviewer for Alzheimer Research • Reviewer for Molecular Pharmacology • Reviewer for Biochimica et Biophysica Acta (BBA - Molecular Cell Research). • Reviewer for Biochemical Pharmacology • Reviewer for BBRC • Reviewer for Brain Research • Reviewer for Canadian Journal of Physiology and Pharmacology • Reviewer for Molecular and Cellular Biochemistry • Reviewer for Neurotoxicity Research • Reviewer for Molecular Vision • Reviewer for Glia • Reviewer for Vaccine • Reviewer for Cell Calcium • Reviewer for AIDS Research and Human Retroviruses • Reviewer for Current Cancer Therapy Reviews • Reviewer for Springer’s book review (total 3).

Grant Review Activities

• Permanent Member, NIH, Oral, Dental and Craniofacial Sciences study section (2015-2019).

• Reviewer for the Belgium Research Agency for 2017. • Reviewer for the French National Research Agency, France for 2016 • Reviewer for the Belgium Research Agency for 2016 • Reviewer for National Institute on Drug Abuse, Cutting-Edge Basic Research Awards

(CEBRA) in 2016.

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• Ad hoc reviewer for U.S.-Israel Binational Science Foundation for 2016. • Reviewer for National Science Centre, Poland, 2015. • DOD FY 2015 Lung Cancer Research Program Exploration-Hypothesis Development

Award panel. • Reviewer for Fund for Scientific Research-FNRS (F.R.S), Brussels Belgium, 2015 • Ad hoc Member, NIH, Oral, Dental and Craniofacial Sciences study section (June and Oct

cycle in 2014). • DOD FY 2014 Lung Cancer Research Program Exploration-Hypothesis Development

Award panel. • DOD FY 2014 Prostate Cancer Research Program Exploration-Hypothesis Development

Award (EHD-MBG) panel. • Reviewer for UK Research Foundation, 2014. • Reviewer for Association for International Cancer Research (AICR), Australia, 2014 • Co-Chairperson ZRG1 MOSS-C (02) Musculoskeletal, Oral and Skin Sciences Study

Section (Dec 2013). • DOD FY 2013 Lung Cancer Research Program Exploration-Hypothesis Development

Award panel. • Ad hoc Member, Musculoskeletal, Oral and Skin Sciences Study Section (June 2013) • DOD FY 2013 Prostate Cancer Research Program Exploration-Hypothesis

Development Award (EHD-MBG) panel. • Ad hoc Member, Neurosciences Fellowship Study Section (F01) (June 2013) • Reviewer for National Science Centre, Poland, 2013 • Reviewer for French National Research Agency (ANR), France, 2013. • Ad hoc Member, NIH, Oral, Dental and Craniofacial Sciences study section (June 2013) • Ad hoc Member, Neurosciences Fellowship Study Section (F01) (March 2013) • Ad hoc Member, NIH, Oral, Dental and Craniofacial Sciences study section (Feb 2013) • Ad hoc Member, Neurosciences Fellowship Study Section (F01) (2012) • DOD FY 2012 Prostate Cancer Research Program (PCRP) Exploration-Hypothesis

Development Award (EHD-MBG) panel • Ad hoc Member, NIH, Musculoskeletal, Oral and Skin Sciences study section

(2011/2012) (ZRG1 MOSS-S(02)). • Ad hoc Member, NIH, Musculoskeletal, Oral and Skin Sciences study section (2011)

(ZRG1 MOSS-C90). • Ad hoc Member, NIH, NIDCR, DSR study section (2011). • Online Peer Review Panel BCRP Molecular Biology and Genetics-1 for the Idea

Program of the Department of Defense, US (2011). • Online Peer Review Panel PCRP Cell biology panel for the Idea Program of the

Department of Defense, US (2011). • UK Parkinson’s foundation since 2011 • Full member Peer Review Concept Award for Prostate Cancer for the Department

of Defense, US (2010). • Full member Peer Review Panel BCRP Molecular Biology and Genetics-3 for the

Idea Program of the Department of Defense, US (2010). • Ad hoc reviewer for U.S.-Israel Binational Science Foundation (2010-) • Full member Peer Review Concept Award for Lung Cancer for the Department of

Defense, US (2009). • Full member Peer Review Concept Award for Breast Cancer. Molecular Biology

and Genetics-1 section for the Department of Defense, US (2009). • Ad hoc reviewer (Carrier award) for Austrian National Science Foundation, (2009)

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• Full member Peer Review Concept Award for prostate cancer for the Department of Defense, US (2009).

• Full member Peer Review Concept Award Molecular Biology and Genetics-1 for the Department of Defense, US (2008).

• Full member Peer Review Panel BCRP Molecular Biology and Genetics-3 for the Idea Program of the Department of Defense, US (2008).

• Ad hoc reviewer (Carrier award) for National Science Foundation, US (2008-) • Ad hoc Member, NIH, Oral, Dental and Craniofacial Sciences study section (2007) • Full member Peer Review Panel BCRP Molecular Biology and Genetics-3 for the

Idea Program of the Department of Defense, US (2007). • Ad hoc Reviewer for Philip Morris External Research Program (2007-). • Full member Peer Review Panel for Molecular Biology and Genetics-3 for the

Idea Program of the Department of Defense, US (2006). • Reviewer Seed Money grants proposals for School of Medicine & Health Sciences 2005-. • Ad hoc reviewer for SBIR/STTR grants for the Department of Energy, US (2005-). • Ad hoc reviewer for the U.S. Civilian Research & Development Foundation (2005-). • Ad hoc reviewer (Research award) for American Arthritis foundation, US (2004-). • Ad hoc reviewer (Carrier award) for Czech Science Foundation, Czechoslovakia (2004-).

External Evaluator

• External evaluator for tenure and promotion (to Associate Professor) for the Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA.

• External evaluator for promotion (to Professor) for the Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA.

• External evaluator for tenure and promotion (to Associate Professor) for the Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

INVITED LECTURES/PRESENTATIONS

Invited Lectures

• Characterization of amino acids necessary for oxygen stability of Ferredoxin, Molecular Biochemistry section, University of Bonn, Germany March 22nd 1997.

• “Retinal degeneration: the role of RanBP2” Presented at Department of Pharmacology and therapeutics, Medical College of Wisconsin, Milwaukee, on December 18th 1998.

• “Export of RanBP2: a unique tale of protein-protein interaction” Presented at NIDCR, NIH on January 12th 1999.

• “TRPC1 a candidate for SOCE channels”. Presented at the Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma on May 27th 2001.

• “TRPC1 a functional analysis on its store-operated calcium channels properties”. Presented at NIDCR, NIH on March 07th 2002.

• “Molecular and biochemical characterization of TRPC1: A functional role in SOCE”. Presented at the Department of Biochemistry, School of Veterinary Sciences University of Columbia, Missouri on May 20th 2002.

• “Molecular characterization of TRPC1”. Presented at the Department of Biochemistry and Molecular Biology, Grand Forks, North Dakota April 19th 2002.

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• “Calcium Signaling: Role of TRP proteins”. Presented at the Department of Chemistry and Molecular Biology, Fargo, North Dakota on 19th June 2003.

• “Role of calcium ion channels in Cellular activities”. Presented at the Department of Biology, University of Marry, Bismarck, North Dakota on 20th October 2003.

• “Calcium ion channels Role of TRP proteins” Presented at Department of Biology, Dickinson State University Dickinson, North Dakota on 22nd October 2003.

• “Role of calcium ion channels in relevant proteins in regulation of cellular activities”. Presented at BRIN Faculty Exchange Seminar, Department of Chemistry Minot State University Minot, North Dakota on 23rd October 2003.

• “Calcium Influx: What we know and what we don’t” Presented at the Foundation of Biomedical Science Seminar Series, School of Medicine and Health Sciences, Grand Forks on October 24th, 2003

• “TRP proteins and calcium Influx”. Presented at Biochemistry and Molecular Biology Seminar Series, School of Medicine and Health Sciences, Grand Forks, North Dakota on 30th October 2003.

• Invited to give a talk at the Department of Anatomy and Cell Biology, School of Medicine and Health Sciences, Grand Forks, North Dakota on "Trafficking of TRPC proteins to the membrane" on 22nd March 2004.

• TRPC3 its role and function in the neuron. Presented at North Dakota Science Academy, Fargo, North Dakota 2004.

• TRPC1 and its role in cell proliferation. Presented at Jiwaji Institute of Technology, Gwalior, India on January 12th 2006.

• The role of TRP proteins in Parkinson disease and Neurosecretion. Presented at 4th annual Neuroscience meeting, Grand Forks, ND, December 1st, 2006.

• “TRPC1, its regulation and function in diseases” presented at Biochemistry Department, Temple University, December 2007.

• “TRPC1 and its role in saliva secretion” presented at the Department of Oral Biology, New York University, Buffalo, New York, January 2008.

• “TRPC1 and its role in neurodegenerative diseases” presented at North Dakota State University Joint ND-COBRE session, February 2009.

• “TRPC1 function as an SOCE channel in dopaminergic neurons” presented at UND-COBRE symposium, October 2010.

• “TRPC1 function and regulation in dopaminergic neurons” presented at NIHES, NIH, June 2011.

• “Cav1 and lipid raft-mediated regulation of TRPC1 in non-excitable cells” presented at Mayo Clinic, Rochester, July 2011.

• “Calcium Signaling, old sage new players” presented at Salivary gland and Exocrine secretion Gordon Conference, Galveston, TX, Feb 2013.

• “Calcium and Cell physiology” presented at Physiology Department, Stillwater Oklahoma, August 2014.

• “TRPC1 mediated regulation of ion channel essential for secretion” presented at Arthur Dugoni Dental School, Pacific University, San Francisco, CA, March 2015.

• “TRPC1 and Saliva Secretion” presented at Basic and Craniofacial Department, School of Dentistry, New York University, New York, NY, April 2015.

• “Biology of Ca2+ signaling” at Georgia State University, Biology Department, Atlanta, GA, May 2015.

• Calcium and neuronal function at University of Toledo Medical College, Toledo, Ohio, June 2015.

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• “Calcium signaling in cancer and neurodegeneration” presented at Roseman University, Las Vegas, NV, Feb 2016.

Professional Meetings Attended/Presented • Chaired a session and oral presentation at the Salivary gland and Exocrine secretion

Gordon Conference, Galveston, TX, Feb 2017. • Attended Calcium Signaling Gordon Conference in June 2015 at Sunday River, Maine. • Attended the Gordon Conference on Salivary gland and Exocrine Biology Gordon

Conference, Galveston, TX in 2015. • Chaired a session and oral presentation at the Salivary gland and Exocrine secretion

Gordon Conference, Galveston, TX, Feb 2013. • Attended the Gordon Conference on Calcium Signaling in July 2011 held at Colby

College, Maine. • Attended and presented at the IIIrd Biennial national IDeA symposium of Biomedical

Research Excellence in 2010. • Attended the Gordon Conference on Calcium Signaling in July 2009 held at Italy. • Attended a conference on Salivary gland physiology organized by oral biology

Rochester, NY in June 2008. • Attended and presented at the IInd Biennial national IDeA symposium of Biomedical

Research Excellence in 2008. • Attended Calcium Signaling Gordon Conference (July 2007) held at Tilton College, NH. • Attended and invited as a judge for poster competition for the Gordon Conference on

Salivary gland secretion in Feb 2007 held at Ventura, California. • Attended Ist Biennial National IDeA symposium of Biomedical Research Excellence in

2006. • Attended North Dakota Academy of Science meeting in 2006. • Attended Gordon Salivary gland secretion in Feb 2005 held at Ventura, California. • Attended North Dakota Academy of Science meeting in 2005 • Attended the 2004 ND- EPSCoR Conference held in Grand Forks, • Presented a talk at the North Dakota Academy of Science meeting in 2004 • Presented a poster at the Neuroscience meeting in the year 2004. • Attended the NSF regional Grant Conference hosted by the University of Minnesota

on November 9th – 11th 2003. • Presented a poster at the 2003 ND/SD EPSCoR Joint Biennial Conference. • Invited to attend the Metalloproteinase meeting organized by the Department of

Chemistry & Molecular Biology, NDSU (May 30-June 1, 2003) • Attended and presented at the 42nd American society for Cell Biology, Annual

Meeting, San Francisco, CA, 2002. • Attended and presented at the Experimental Biology, annual meeting, New Orleans,

Louisiana, 2002. • Attended and presented at the FASEB summer conference on calcium cell function in

June 2002 at Salt Lake City Utah. • Presented at the Experimental Biology, annual meeting, Orlando, Florida, 2001. • Presented at the 40th ASCB, Annual Meeting, San Francisco, CA, 2000. • Attended and presented at the FASEB summer conference on calcium cell function in

June 2000 at Copper Mountains, Colorado. • Presented at the American Society for Biochemistry and Molecular Biology,

International meeting, held in Boston, Massachusetts, 2000.

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• Presented at the Association for Research in Vision and Ophthalmology (ARVO), Annual meeting, held in Fort Lauderdale, Florida, 2000.

• Presented at the XIX All India Cell Biology Conference, Calcutta, India 1996.

MAJOR COMMITTEE AND SERVICE RESPONSIBILITIES

University/School of Medicine and Health Sciences • Served as chair of the CPT committee for the Department of Basic Science in 2015-2016. • Serving on Administrative Search Committee for the School of Medicine and Health

Sciences (SMHS) since 2013-present. • Serving on the Research Committee for SMHS from 2013-present. • Serving on University-wide Associate Deans for Research Committee since 2011. • Serving on University-wide Seed Grant Committee since 2011. • Serving on Founders Day awards committee since 2012. • Served on the LCME committee for faculty affairs for the reaccreditation of the School of

Medicine and Health Sciences in 2012. • Serving on the School of Medicine and Health Sciences tenure and promotion committee

since 2011-present • Served as chair of the CPT committee for the Department of Biochemistry and Molecular

Biology in 2012. • Serving on the Seed Money grant committee for the University of North Dakota since

2011-present. • Nominated by the Dean of the School of Medicine and Health Sciences to serve on the

Research Committee for 3 years (2011-2013). • Serving on the PPT Departmental tenure and promotion committee since 2011 • Served as Vice Chair on the school-wide Basic Science Recruitment Committee 2010-

2011. • Serving on the Animal Care Committee since 2009. • Serving as Bock I design team for the School of Medicine and Health Sciences since 2009. • Served as a reviewer for the evaluation of the Seed Money grant proposals for the

University of North Dakota in 2010. • Judged Poster Competition at the 29th Frank Low Research day held on April 30th 2009. • Served as a reviewer for the evaluation of the Seed Money grant proposals for the

University of North Dakota, School of Medicine and Health Sciences in 2009. • Served as a reviewer for the evaluation of the Seed Money grant proposals for the

University of North Dakota, School of Medicine and Health Sciences in 2008. • Served on the Graduate Curriculum Committee (GCC) 2006-2009. • Nominated by the Dean of the School of Medicine and Health Sciences to serve on the

Research Committee for 3 years (2006-2009). • Served as a reviewer for the evaluation of the Seed Money grant proposals for the

University of North Dakota, School of Medicine and Health Sciences in 2007. • Participated and met with the evaluators of the LCME site visit for the accreditation of the

School of Medicine and Health Sciences in 2006. • Judged Poster Competition at the Basic Science Retreat, September 24-25 2004. • Was involved in meeting and in the selection of candidates for various faculty

positions in the Departments of Pharmacology, Physiology, and Therapeutics, and in Anatomy and Cell biology.

• Judged Poster Competition at the 23rd Frank Low Research day held on April 24th 2003.

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Departmental • Initiated and maintained Biochemistry and Molecular Biology seminar series for the

year 2003- 2006. • Was actively engaged in the recruitment of graduate and medical students from

North Dakota and nearby states. • Contacted the officials and organized a visit to Jamestown, Valley City, Fargo, and

Minot undergraduate colleges for recruitment of the students. • Interviewed several prospective graduate students for fall 2003, 2004, 2005, 2006. • Along with the Biochemistry, faculty was involved in the recruitment of Dr. Min

Wu for assistant professor position (2003). • Along with Dr. Homandberg and two graduate students visited University of Mary,

Dickinson State University, and Minot State University for the recruitment of prospective graduate students.

• Along with the Biochemistry, faculty was involved in the recruitment of Dr. Gao for assistant professor position (2006).

• Along with the Biochemistry, faculty was involved in the recruitment of Dr. Ohm for assistant professor position (2008).

• Serving on the Departmental tenure and promotion committee since 2008. • Chair for the CPT evaluation for Dr. Homandberg (Professor and Chair,

Biochemistry and molecular Biology) in 2009 • Chair for the CPT evaluation for Dr. Ohm (Assistant Professor, Biochemistry and

molecular Biology) in the year 2010, 2011, and 2012. • Chair for the departmental CPT for the year 2012/13.

Graduate students committees

• Graduate committee member for Danielle Rastedt from 2010 • Graduate committee member for Yan Ye from 2010 • Graduate committee member for Michael Tomlinson from 2011 • Graduate committee member for Jessica Warns from 2013

Other significant services • Served as a session chair at the Salivary Gland Gordon conference in 2013. • Served as a judge for poster competition at Salivary Gland Gordon conference in 2007. • Served as a judge in the Brain Bee (Grand Forks) competition in 2007. • Organized a workshop on microarray principles and implementations for graduate

students at the School of Medicine and Health Sciences in 2007.

STUDENTS AND FELLOWS Graduate Committee Chair Sunitha Bollimuntha (2003-2009) Recipient of ND-EPSCoR Doctoral Dissertation Award 2006-2008 Recipient of Ya-Pin Lee Award (2007) Recipient of ASBMB and UND travel Awards, and have won numerous

poster competitions, which were regional, national, and international. Ph.D Thesis Title: “TRPCs and neuronal function” Biswaranjan Pani (2004-2010) Recipient of ND-EPSCoR Doctoral Dissertation Award 2008-2009 Recipient of Ya-Pin Lee Award (2009)

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Recipient of Graduate Summer Scholarship Recipient of Travel awards from UND and won numerous poster awards at regional and national meetings. Ph.D. Thesis Title: “TRPC1 and its regulation and function” Jordan Karlstad (2009-2011) Recipient of ND-EPSCoR Doctoral Dissertation Award 2009-2010 Recipient of Cornatzer Award (2011) MS Thesis Title: “STIM1 and its regulation and function” Ann Schaar (2014-) Ph.D. Thesis Title: “TRPCs and SOCE in Obesity” Recipient of ND-EPSCoR Doctoral Dissertation Award 2016-2017 Jessica Warns (2014-) co-chair Ph.D. Thesis Title: “EMT calcium and gene regulations” F32 submitted and scored pending council review Graduate Committee Member

Mohammad Hamad Ph.D. Microbiology and Immunology (2003-2006) Mark Cervinski Ph.D. Biochemistry and Molecular Biology (2003-2006) Shibi Kannan Ph.D. Biochemistry and Molecular Biology (2003-2008) Jara Javier Ph.D. Pharmacology, Physiology & Therapeutics (2004-2008) Chandra Bathula Ph.D. Biochemistry and Molecular Biology (2005-2010) Melody Toosky Ph.D. Microbiology and Immunology (2006-2011) Amy Moritz Ph.D. Biochemistry and Molecular Biology (2006-2011) Gunjan Dhawan Ph.D. Pharmacology, Physiology & Therapeutics (2007-2011) Chyuan Yan Ph.D. Biochemistry and Molecular Biology (2006-2012) Jason Ashvig Ph.D. Anatomy and Cell Biology (2007-2012) Bhanu Desari Ph.D. Pharmacology, Physiology & Therapeutics (2007-2012) Michael Schott Ph.D. Anatomy and Cell Biology (2009-2014) Sathya Challa Ph.D. Biochemistry and Molecular Biology (2009-2014) Yan Ye Ph.D. Biochemistry and Molecular Biology (2010-) Rejwi Acharya Ph.D. Biochemistry and Molecular Biology (2010-2014) Danielle Rastedt Ph.D. Biochemistry and Molecular Biology (2010-) Michael Tomlinson MS. Biochemistry and Molecular Biology (2010-) Jessica Warns Ph.D. Biochemistry and Molecular Biology (2013-)

Undergraduate and Medical School Research Students Debaro Liao, Colgate University (2000) Brooke Blicher, Colgate University (2001)

Manjari Bhatte New Jersey Dental School (2001) Eric Cornatzer University of North Dakota (2003-2004) Todd Dupong University of North Dakota (2003-2005) Afsaneh Shamlou University of North Dakota (2004) Ashley Bansal Red River high School (2003-2004) Nadia Mac University of North Dakota (2004) Sheela Damle Cornell University (2006) Kristina Rouser University of North Dakota (2006-) Lara Schmidt University of North Dakota (2006) Yassin Labyed University of North Dakota (2006-2007) Ravi Panji University of North Dakota (2008-2010) Alexis Hanson Red River high School (2009-2010)

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Joshua Maliske University of North Dakota (2011-2012) Dhilhan Marasinghe Carleton College, MN (2012-) Lucas Schnaidt University of North Dakota (2013-)

Postdoctoral Fellows 2006-2007 Bidhan Bandyopadhyay, Ph.D. Presently Assistant Professor at VA Medical

Center, Washington DC 2007-2011 Senthil Selvaraj, Ph.D, Presently Senior Scientist (independent position) at Qatar

Cardiovascular Research Center 2009- 2012 Sunitha Bollimuntha, Ph.D, Presently Research Fellow at NIHES, NC 2009- 2012 Biswaranjan Pani, Ph.D Presently Research Fellow at Duke University, NC 2008- Yuyang Sun, Ph.D. 2013- Pramod Sukumaran, Ph.D.

Technicians

2006- Virginia Achen 2006 Shree Paudal 2006-2007 Kristina Rauser

TEACHING ACTIVITIES

UND School of Medicine (lectures)

• Delivered five lectures for Medical Students (Block-1) (August/September 2016). (Mean Score 4.5/5.0)

• Delivered one lecture for Medical Students (Block-III) (February 2016). • Delivered five lectures for Medical Students (Block-1) (August/September 2015).

(Mean Score 4.46/5.0) • Delivered one lecture for Medical Students (Block-III) (February 2015). • Delivered five lectures for Medical Students (Block-1) (August/September 2014)

(Mean Score 4.5/5.0). • Delivered one lecture for Medical Students (Block-III) (February 2013). (Mean

Score 4.6/5.0). • Delivered five lectures for Medical Students (Block-1) (August/September 2013). • Delivered one lecture for Medical Students (Block-III) (February 2013). • Delivered five lectures for Medical Students (Block-1) (August/September 2012)

(Mean Score 4.5/5.0). • Delivered five lectures for Medical Students (Block-1) (August/September 2011)

(Mean Score 4.4/5.0). • Delivered five lectures for Medical Students (Block-1) (September/October 2010)

(Mean Score 4.3/5.0). • Delivered five lectures for Medical Students (Block-1) (September/October 2009)

(Mean Score 4.51/5.0). • Delivered four lectures for Medical Students (Block-1) (September/October 2008).

(Mean Score 4.78/5.0). • Delivered two lectures for Medical Students (Block-1) (September 18-19th 2007)

"Cell Signaling overview and Insulin Signaling”. (Mean Score 4.59/5.0). • Delivered two lectures for Medical Students (Block-1) (September 19-20th 2006)

"Cell Signaling overview and Insulin Signaling”. (Mean Score 4.38/5.0).

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• Delivered one lecture for Medical Students (Block-1) (September 14th 2005) "Overview of Cell Signaling”. (Mean Score 4.20/5.0).

Problem- based learning (PCL) • Served as a facilitator in patient-Centered Learning Curriculum (Problem Based

Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2016. (Mean score 5.0/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2015. (Mean score 4.95/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2014. (Mean score 4.9/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2013. (Mean score 4.7/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2012. (Mean score 4.9/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for inter-health professional. Late spring 2012. (Mean score 4.75/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2011. (Mean score 4.96/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VI) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2010. (Mean score 4.98/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block IV) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2009. (Mean score 4.89/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block II) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2008. (Mean score 4.68/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block III) for a total of 8 weeks (7 hours direct contact each week). Jan-March 2008. (Mean score 4.63/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for inter-health professional. Late spring 2007. (Mean Score 4.48/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block II) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2006. (Mean score 4.79/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block II) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2005. (Mean Score 4.50/5.0).

• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block II) for a total of 8 weeks (7 hours direct contact each week). Oct-Dec 2004. (Mean Score 4.25/5.0).

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• Served as a facilitator in patient-Centered Learning Curriculum (Problem Based Curriculum) for medical students (Block VIII) for a total of 8 weeks (7 hours direct contact each week). March-May 2003 (Mean Score 3.75/5.0).

UND Graduate Core Course (BIMD)

• Conducted lab course on antibody production and application on August 17th, 2003 to graduate students in Core Course BIMD 500

• Delivered a lecture at BIMD 512 (October 24th, 2003) "Calcium influx what we know and what we don’t".

• Conducted lab course on antibody production and application on August 13 and 15th 2004 to graduate students in Core Course BIMD 500.

• Delivered three lectures to graduate students in Core Course BIMD 500, August 2004, on Cell Signaling.

• Conducted Biochemistry and Molecular Biology lab courses to graduate students in Core Course BIMD 500 for the year 2004.

• Delivered two lectures and one problem-solving session to graduate students in Core Course BIMD 500, in 2005, 2006, 2007, 2008, on Cell and intracellular signaling.

• Delivered five lectures and one problem-solving session to graduate students in Core Course BIMD 500, in 2009.

• Delivered five lectures and one problem-solving session to graduate students in Core Course BIMD 500, in 2010.

• Delivered three lectures to graduate students in Core Course BIMD 500, in 2011, 2012, and 2013.

• Delivered 1 lecture and worked with BIMD 503 module graduate students for a week (7 contact hours), also was involved in evaluating and public speaking.

Advance Course

• Delivered one lecture at PPT 527 (January 27, 2004) TRPC proteins and synaptic transmission

• Coordinated student presentation for PPT 527 on January 29th, 2004. • Course Director (1 module, 537) Delivered eight lectures for advanced

Biochemistry (BMB 532) and was involved in formulation and evaluation of the course (2004). (Evaluations received were excellent)

• Course Director (514) Current Literature in the year 2005. • Delivered one lecture at PPT 527 (January 20, 2006) TRP proteins calcium and

synaptic transmission. • Course Director (514) Current Literature for the year 2006. • Coordinated student presentation for PPT 527 on January 29th, 2006. • Course Director (1 module, 537) Advance Course in Molecular Biology in the year

2006 and was involved in the formulation as well as evaluation of the course. (Evaluations received were excellent).

• Delivered two lectures at PPT 540 (November 30 and December 04 2006). • Course Director (514) Current Literature in the year 2007. • Delivered two lectures at PPT 540 (November 29 and December 03 2008).

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• Course Director (1 module, 537) Delivered eight lectures for advanced Biochemistry (BMB 532) and was involved in formulation and evaluation of the course 2008.

• Delivered one lecture at PPT 527 (2011) TRPC proteins and survival of dopaminergic neurons and participated in evaluating the specific aim page.

• Course Director (1 module, 537) Delivered eight lectures for advanced Biochemistry (BMB 532) in 2011.

• Course Director (514) Current Literature in the year 2013. • Delivered one lecture at PPT 527 (March 20, 2013) TRP proteins calcium and

synaptic transmission and participated in student presentations. • Delivered one lecture and one hands-on demonstration for PPT 525 (Feb 2015) on

electrophysiology in non-excitable cells (contact hours 4). • Proposal Review for BIMD 518 Students (3 students) for 2013 and 2014.

Undergraduate

• Taught Molecular Biology course (including labs) to undergraduate students in BMB 403 for the year 2004, 2005, 2006, 2007, 2008 and 2009.

Informal instruction • Mentored Biochemistry 494, Directed Studies for Eric Cornatzer and Todd Dupong for fall

semester 2003 (total 8 credits) • Mentoring Biochemistry 494, Directed Studies for Eric Cornatzer and Afsaneh Shamlou

for spring semester 2004 (total 6 credits). • Mentored Ashley Bansal a Red River high school student to do summer research at

University of North Dakota (2003-2004). • Mentored Biochemistry 494, Directed Studies for Eric Cornatzer and Nadia Mac for fall

semester (2004) (total 6 credits). • Mentored Sheela Damle from Cornell University for research in her winter break for the

year 2005. • Mentored Biochemistry 494, Directed Studies for Eric Cornatzer and Nadia Mac for fall

semester (2004) (total 6 credits). • Mentored Kristina Rouser from UND for research in her summer break for the year 2006. • Mentored Biochemistry 494, Directed Studies for Kristina Rouser and Lara Schmidt for fall

semester (2006) (total 6 credits). • Mentoring Biochemistry 494, Directed Studies for Kristina Rouser for spring semester

(2007) (total 4 credits). • Mentoring Sunitha Bollimuntha for the fall and spring semester 2003, 2004, 2005, 2006

(total 52 credits) • Mentoring Biswaranjan Pani for the fall and spring semester, 2004, 2005, 2005, 2006 (total

36 credits) • Served as a chair on the graduate committee of Sunitha Bollimuntha, Department of

Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota.

• Served as a chair on the graduate committee of Biswaranjan Pani, Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences.

• Served on the graduate committee of Mohammad Hamad, Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences.

• Served on the graduate committees for more than 10 graduate students.

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• Serving on the graduate committee of four graduate students, Department of Biochemistry and Molecular Biology University of North Dakota School of Medicine and Health Sciences

Curriculum/Professional Development

• Participated in a year-long Grant writing workshop organized by BRIN 2004-2005. • Participated in the revision of the BIMD 500 (cell signaling module) core course. • Participated in the development and revision of BMB-402 course. • Organized a workshop on microarray principles and implementations for graduate

students at the School of Medicine and Health Sciences. • Serving as Bock I design team for the School of Medicine since 2009. • Serving on Module-3 core course development for BIMD502 graduate program • Serving on Cell and Molecular Biology Track for BMD graduate students.

LIST OF PUBLICATIONS:

1. Sun, Y., Zhang, H., Selvaraj, S., Sukumaran, P., Lei, S., Birnbaumer, L., and Singh B.B. (2017).

Inhibition of Cav1.3 channels by STIM1 in dopaminergic neurons is regulated by TRPC1. Journal of Neuroscience. (In press).

2. Schaar, A., Sun, Y., Sukumaran, P., Dhasarathy, A., and Singh, B.B (2016) TRPC1 and STIM1

are critical for TGFβ induced EMT migration through regulation of calpains. Oncotarget. Oct 25: 7 (49): 80554-80567.

3. Madeo, M., Sun, Y., Chandrasekar, I., Yarrow, A., Cordeiro, D., McCormick, E.M., Murarescu, C. C., Nolan, PM., Acevedo-Arozena, A., Singh, B.B., and Kruer, MC (2016). Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy. American Journal of Human Genetics (Cell Press). Jun 2;98 (6):1249-55.

4. Sun, Y., Sukumaran, P., Selvaraj, S., Schaar, A., Cilz, N., Lei, S., and Singh, B.B (2016). TRPM2 inhibition protects neurotoxin MPP+-induced oxidative stress-mediated cell degeneration. Molecular Neurobiology. Dec 12. [Epub ahead of print]

5. Sukumaran, P., Sun, Y., Schaar, A., Selvaraj, S and Singh, B.B (2016). The role of TRPC channels

in Parkinson’s disease In TRPC channels and Brain Diseases (Eds JunFeng Wang Springer Nature. Advances in Experimental Medicine and Biology, Vol. 976, Chapter 8, In press.

6. Sukumaran, P., Schaar, A., Sun, Y., and Singh, B.B (2016). Functional role of TRP channels in modulating ER stress and Autophagy. Cell Calcium. Aug; 60 (2):123-132.

7. Sun, Y., Sukumaran, P., Schaar, A., and Singh, B.B (2015).TRPM7 and its role in neuro-

degenerative diseases. Channels. 9:5, 244-252 8. Sukumaran, P., Sun, Y., Vyas, M., and Singh, B.B (2015). TRPC1-mediated Ca2+ entry is essential

for the regulation of hypoxia and nutrient depletion-dependent autophagy in salivary gland cells. Cell Death and Disease. Mar 5;6:e1674. doi: 10.1038/cddis.2015.7.

9. Selvaraj, S., Singh, B.B., Bollensdorff, C., Suwaidi, J AL., Yacoub, M (2015). A critical role of

TRPC1-ORAI1-STIM1 mediated store-operated calcium entry in cardiac hypertrophy. Journal of the American College of Cardiology. 65(10_S):. doi:10.1016/S0735-1097(15)60902-0

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10. Zhou, X., Ye, Y., Sun, Y., Privratsky, B., Wang, W., Birnbaumer, L., Wu, M., and Singh, B.B (2015). TRPC1 deficiency impairs host defense and proinflammatory responses to bacterial infection by regulating PKC signaling Molecular and Cellular Biology. 35(16):2729-2739.

11. Selvaraj, S., Sun, Y., Sukumaran, P., and Singh, B.B (2015). Resveratrol- activates autophagic cell

death in cancer cells via down regulation of TRPC1-STIM1 and the mTOR pathway. Molecular Carcinogenesis. Apr 27. doi: 10.1002/mc.22324.

12. Chauhan, A., Quenum, F., Abbas, A., Bradley, DA., Nechaev, S., Singh, B.B., Sharma, J., Mishra,

B.B (2015). Epigenetic modulation of microglial inflammatory gene loci in helminth-induced immune suppression. ASN Neuro. Jul 6;7(4). pii: 1759091415592126.

13. Sun, Y., Birnbaumer, L and Singh, B.B (2015). TRPC1 regulate calcium-activated chloride

channels in salivary gland tissues and cells. Journal of Cellular Physiology. 230(11):2848-56. 14. Sun, Y., Chauhan, A., Sharma, J., Singh, B.B., and Mishra, BB (2014). Inhibition of store-

operated Ca2+ entry in microglia by helminth antigens. Journal of Neuroinflammation. 11, 1 (Dec 24, 2014).

15. Sun, Y., Sukumaran, P., Varma, A., S Derry, S., Sahmoun, A. E., and Singh, B.B. (2014).

Cholesterol-induced activation of TRPM7 regulates cell viability, proliferation, and migration of human cancer cells Biochim Biophys Acta. 1843 (9), 1839–1850.

16. Chauhan, A., Sun, Y., Pani, B., Fredice, Q., Sharma, J., Singh, B.B., and Mishra, BB (2014).

Helminth-induced suppression of macrophage activation is correlated with inhibition of calcium channel activity PLOS1. Jul 11;9 (7):e101023. doi: 10.1371

17. Sun, Y., Sukumaran, P., and Singh, B.B. (2014). Physiological function and characterization of

TRPCs in non-excitable and excitable cells. Cells. 3(2), 455-475. 18. Pabelick, C. M., Singh, B.B, and Prakash. Y.S (2014). The role of Caveolae in the Airway in

Calcium Signaling In Airway Smooth Muscle Cells (Editor Yong-Xiao) Springer Heidelberg 235-246.

19. Pani, B., Xibao L., Bollimuntha, S., Ingrid, R., Chen, O., Achen, V., Patel, HH, Ambudkar IS., and

Singh, B.B. (2013). Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1. Journal of Cell Science 126, 667-675.

20. Dasari, B Jaya Prasanthi R.P., Meiers, C., Singh, B.B. and Ghribi, O (2013). Differential effects of

the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. Current Eye Research Online, 1–13.

21. Vohra, PK., Sathish, V., Thompson, MA. Kiel, A., Pabelick, CM., Singh, B.B and Prakash Y.S.

(2013). TRPC3 Regulates Release of Brain-Derived Neurotrophic Factor From Human Airway Smooth Muscle Biochim Biophys Acta. Jul 27; 1833 (12): 2953-2960.

22. Sun, Y., Selvaraj, S., Varma, A., S Derry, S., Sahmoun, A. E., and Singh, B.B. (2013). The increase

in serum Ca2+/Mg2+ ratio promotes cell proliferation of prostate cancer cells by activating the TRPM7 channel. Journal of Biological Chemistry 288, 255-263.

23. Mandavilli, S., Sahmoun, A. E., and Singh, B.B (2013). Association between serum calcium levels,

calcium channels, microcalcification and breast cancer using breast imaging reporting and data system scores Breast Cancer treatment and therapy 5, 1 – 7.

24. Selvaraj, S., Sun, Y., Watt, J.A., Song, S., Lei, S., Birnbaumer, L and Singh, B.B (2012). Toxin- induced ER stress in mice involves downregulation of TRPC1 and inhibition of the AKT/mTOR

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signaling. Journal of Clinical Investigation. 122 (4) 1354-1367. Highlighted with a commentary in JCI and also recommended by the faculty of 1000.

25. Kost, GC., Selvaraj, S., Lee, YB., Kim, DJ., Ahn, C-H., and Singh, B.B. (2012). Clavulanic acid

inhibits MPP+-induced ROS generation and subsequent loss of dopaminergic cells. Brain Research 1469:129-135

26. Singh, B.B, Christina M Pabelick and Y S Prakash. (2012). Canonical Transient Receptor Potential

channel expression, regulation and function in vascular and airway diseases TRP channels in drug discovery (Editors Arpad Szallasi and Tamas Biro) Humana Press. Chapter 4, 61-87.

27. Sahmoun, A.B, and Singh, B.B. (2012). Calcium homeostasis and Cancer. Environment and

Biotechnology (Editors Ram Prasad and Arvind Kumar) Lambert Academic Press. Chapter 4, 89-109.

28. Guo, Q, Shen, N, Yuan, K, Li, J, Wu, H, Zeng, Y, Fox, J,. Bansal, A. K, Gao, H, Singh, B B, and Wu, M (2012). Caveolin -1 plays a critical role in host immunity against Klebsiella pneumoniae by regulating STAT5 and Akt activity. Eur J Immunol 42 (6):1500-1511.

29. Bollimuntha, S, Pani, B., and Singh, B.B. (2012). The pathophysiological perspective of neuronal store-operated Ca2+ signaling. Store-operated calcium entry pathways (Klaus Groschner and Christopher Romanian eds) Springer Heidelberg Chapter 26, 245-254.

30. Karlstad, J., Sun, Y and Singh, B.B. (2012). Ca2+ signaling: an outlook on the characterization of

Ca2+ channels and their importance in cellular functions. Advances in Experimental Medicine and Biology. 740, 143-157.

31. Pani, B., Bollimuntha, S and Singh, B.B. (2012). The TR(i)P to Ca2+ signaling just got STIMy: an

update on STIM1 activated TRPC channels. Frontiers in Biosciences Jan 1;17:805-823. 32. Kost, GC., Selvaraj, S., Lee, YB., Kim, DJ., Ahn, C-H., and Singh, B.B. (2011). Clavulanic acid

enhances dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking. Neuroscience letters 504, 170-175.

33. Dasari, B., Jaya Prasanthi R.P., Marwarha, G., Singh, B.B. and Ghribi, O (2011). Cholesterol-

Enriched Diet Causes Age-Related Macular Degeneration-Like Pathology in Rabbit retina. BMC Ophthalmology. 11:22-29.

34. Yuan, K, Huang C, Fox J, Gaid M, Weaver A, Li G, Singh B.B, Gao H, Wu M (2011). The

elevated inflammatory response is mediated by STAT3 and NF-κB in Caveolin-1 deficient mice in P. aeruginosa infection. Journal of Biological Chemistry 286 (24): 21814-25.

35. Bollimuntha, S., Selvaraj, S and Singh, B.B. (2011). Emerging role of canonical TRP channels in

Neuronal function. Advances in Experimental Medicine and Biology. 704, 573-593. 36. Dasari, B Jaya Prasanthi R.P., Marwarha, G., Singh, B.B. and Ghribi, O (2010). The oxysterol 27-

hydroxycholesterol increases beta-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmology. 10: 22-31.

37. Labyed Y, Kaabouch N, Schultz RR, Singh, B.B, and Milavetz B. (2010). An improved 1-D gel

electrophoresis image analysis system. Advances in Experimental Medicine and Biology. 680:609-617.

38. Sahmoun, A.B, and Singh, B.B. (2010). Does higher ratio of serum calcium to magnesium

increases the risk of postmenopausal breast cancer? Medical Hypotheses 75, 315-318.

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39. Liu, X., Ong, H.L., Pani, B., Katherine Johnson, Abinav Reddy., William B Swaim., Singh, B.B., and Ambudkar I.S. (2010). Effect of cell swelling on ER/PM junctional interactions and channel assembly involved in SOCE. Cell Calcium. 47, 491-499.

40. Selvaraj, S., Sun, Y., and Singh, B.B. (2010). TRPC channels and their implication in neurological

diseases. CNS and Neurological Disorders-Drug targets. Volume 9, 94-104. 41. Pani, B., Brazer, So-Ching., Xibao Liu, Ong, H.L., Ambudkar IS., and Singh, B.B (2009).

Activation of TRPC1 by STIM1 in ER-PM micro domains involves the release of the channel from its scaffold Caveolin1. Proceedings National Academy of Science. 106, 20087-20092.

42. Selvaraj, S., Watt, J, and Singh, B.B (2009). TRPC1 inhibits apoptotic cell degeneration induced by

dopaminergic neurotoxin MPTP/MPP+ Cell Calcium. 46, 209-218. 43. Ambudkar, I.S, Ong, H.L., and Singh, B.B. (2009). Molecular and functional determinants of Ca2+

signaling microdomains Signal Transduction: Pathways, Mechanisms, and Diseases, (ed Sitaramayya A). Springer, Heidelberg Chapter 13, 237-253.

44. Pani, B, and Singh, B.B. (2009). Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium. 45, 625-633. The second most cited article till date.

45. Pani, B, and Singh, B.B. (2009). Principles and applications of Proteomics: Molecular

determination of TRPC1 target proteins. Textbook on Molecular Biotechnology (Ashok Chauhan and Ajit Varma eds) IK International Publishing house. Chapter 53, 1125-1138.

46. Bandyopadhyay B.C., Ong, H.L., Lockwich, T.P., Liu, X., Paria, B., Singh, B.B., and Ambudkar,

I.S., (2008). TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between IP3R and RACK1. Journal of Biological Chemistry. 283(47):32821-32830.

47. Pani B., Ong, H.L., Liu, X., Rauser, C., Ambudkar, I.S. and Singh, B.B (2008). Lipid Rafts

Determine Clustering of STIM1 in ER-Plasma Membrane Junctions and regulation of SOCE. Journal of Biological Chemistry. 283; 17333-17340.

48. Pani, B, and Singh, B.B. (2008). Dariers disease: a calcium-signaling perspective. Cellular and

Molecular Life Sciences. 65; 205-211. 49. Liu, X., Cheng, O., Bandyopadhyay B.C, Pani B., Dietrich, A., Paria, B., Swaim, W., Birnbaumer,

L., Singh, B.B., and Ambudkar, I.S. (2007). An essential role for TRPC1 in store-operated Ca2+ entry and regulation of salivary gland fluid secretion. Proceedings National Academy of Science, USA. 104; 17542-17547.

50. Ong, H.L., Liu, X, Atanasova, K-T., Singh, B.B., Bandyopadhyay, B., Swaim, W.D., Hegde, R.S.,

Sherman, A, and Ambudkar, I.S. (2007). Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane-endoplasmic reticulum Ca2+ store. Journal of Biological Chemistry. 282; 12176-12185.

51. Labyed, Y., Kaabouch, N., Schultz, R.R., and Singh, B.B. (2007). “Automatic segmentation and

band detection of protein images based on the standard deviation profile and its derivative,” IEEE Electro/Information Technology Proceedings, article. no. 4374497, pp. 577-582.

52. Ong, H.L., Cheng, K.T., Liu, X., Bandyopadhyay, B., Paria, B.C., Soboloff, J., Pani B., Gwasck,

Y., Srikanth, S., Gill, D., Singh, B.B., and Ambudkar, I.S (2007). Dynamic assembly of the TRPC1/STIM1/Orai1 ternary complex is involved in store-operated Ca2+ influx. Journal of Biological Chemistry. 282; 9105-9116.

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53. Jara, J.H, Singh, B.B., Floden, A.M, Hansen, J, and Combs, C.K. (2007). Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. Journal of Neurochemistry. 100; 1407-1420.

54. Pani B., Cornatzer E., Cornatzer W., Shin DM., Pittelkow MR., Ambudkar IS., and Singh B.B.

(2006). Upregulation of TRPC1 following SERCA2 gene silencing promotes cell survival. Molecular Biology of the Cell. 17; 4446-4458.

55. Bollimuntha, S., Ebadi, M., and Singh, B.B (2006). TRPC1 protects SH-SY5Y cells against

salsolinol induced cytotoxicity by inhibiting apoptosis. Brain Research. 1099; 141-149. 56. Liu, X., Bandyopadhyay, B., Nakamoto, T., Singh, B.B., Liedtke, W., Melvin, J.E., and

Ambudkar, I.S. (2006). A role of AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in the regulation of cell volume recovery. Journal of Biological Chemistry. 281; 15485-15495.

57. Liu, X., Bandyopadhyay, B., Singh, B.B., Groschner, K., and Ambudkar, I.S. (2005). Molecular

analysis of a store-operated and OAG sensitive non-selective cation channel. Journal of Biological Chemistry. 280; 21600-21606.

58. Bollimuntha, S., Cornatzer, E, and Singh, B.B (2005). Plasma membrane localization and function

of TRPC1 depend on its interaction with tubulin in epithelium cells. Visual Neuroscience. 22; 163-170.

59. Bollimuntha, S., Shavali, S., Sharma, S.K., Ebadi. M., and Singh, B.B (2005). TRPC1-mediated

inhibition of MPP+ neurotoxicity in human SH-SY5Y neuroblastoma cells. Journal of Biological Chemistry. 280; 2132-2140.

60. Singh, B.B et al., (2004). Moving TRPs to the membrane, Science. 305; 1680. 61. Ebadi, M., Brown-Borg, H., Refaey, H.E., Singh, B.B., Garrett, S., Shavali, S and Sharma, SK

(2005). Metallothionein-mediated neuroprotection in genetically engineered mice models of Parkinson’s disease and aging. Molecular Brain Research. 134; 67-75.

62. Singh, B.B., Lockwich, T., Bandyopadhyay, B., Liu, X., Bollimuntha, S., Brazer, SC., Combs, C.,

Sheng, Z., Knepper, M., Ambudkar, S, and Ambudkar, I.S. (2004). VAMP-2-dependent exocytosis is involved in plasma membrane insertion of TRPC3 channels and contributes to the agonist-stimulated Ca2+ influx. Molecular Cell. 15; 635-646. A summary of this article was published in Nature Cell Biology and Science SKTE.

63. Itagaki, K., Kannan, K.B., Singh B.B and Hauser C.J. (2004). Cytoskeletal reorganization

internalizes multiple Transient Receptor Potential channels and blocks calcium entry into human neutrophils. Journal of Immunology. 172; 601-607.

64. Ambudkar IS, Brazer SC, Liu X, Lockwich T, and Singh, B. B. (2004). Plasma membrane

localization of TRPC channels: the role of caveolar lipid rafts. Mammalian TRP Channels as Molecular Targets (Chadwick DJ and Goode J, eds) Wiley InterScience Publications. 258; 63-70.

65. Brazer, S.W., Singh B.B., Liu, X., Swaim, W & Ambudkar I.S (2003). Caveolin-1 contributes to

assembly of store-operated Ca2+ influx channels in regulating plasma membrane localization of TRPC1. Journal of Biological Chemistry. 278; 27208-15.

66. Singh, B.B*., Liu, X* & Ambudkar, I.S. (2003). Acidic amino acid residues in the S5-S6 region of

TRPC1 contributes to the store-operated Ca2+ influx. Journal of Biological Chemistry. 278; 11337-11343. *both contributed equally

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67. Singh, B.B., Liu, X., Tang, J., Zhu, M.X & Ambudkar, I.S. (2002). .Calmodulin regulates Ca2+-dependent feedback inhibition of store-operated Ca2+ influx by interaction with a site in the C-terminus of TRPC1. Molecular Cell. 9; 739-750.

68. Singh, B.B., Zheng, C., Liu, X., Lockwich, T., Liao, D., Zhu, M., Birnbaumer, L & Ambudkar, I.S.

(2001). TRPC1 dependent enhancement of salivary gland fluid secretion: Role of store-operated calcium entry. FASEB Journal. 15; 1652-1654.

69. Singh, B.B*., Lockwich, T*., Liu, X & Ambudkar, I.S. (2001). Stabilization of cortical actin

induces internalization of TRPC3-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of TRPC3-IP3R association. Journal of Biological Chemistry. 276; 42401-42408. *both contributed equally

70. Yunfei, C., Singh, B.B., Aslanukov, A., Zhao, H and Ferreira, P.A. (2001). The docking of

heterotetrameric kinesins to RanBP2 is mediated via a novel RanBP2 domain. Journal of Biological Chemistry. 276; 41594-41602.

71. Singh, B.B; Curdt, I; Shomburg, D; Bisen, P.S and Böhme, H (2001). Valine 77 of heterocystous

ferredoxin FdxH2 in Anabaena variabilis ATCC 29413 is critical for its oxygen sensitivity. Molecular and Cellular Biochemistry. 217; 137-142.

72. Singh, B.B., Liu, X., & Ambudkar, I.S (2000). Expression of truncated TRPC1: Evidence that the

TRPC1 C-terminus modulates store-operated Ca2+ entry. Journal of Biological Chemistry. 275; 36483 - 36486.

73. Lockwich, T*, Liu, X*., Singh, B.B., Jadlowiec, J. Weiland, S., & Ambudkar I.S (2000). Assembly

of TRPC1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains. Journal of Biological Chemistry. 275; 11934-11942. *both contributed equally

74. Liu, X*., Wang, W*., Singh, B.B., Lockwich, T., Jadlowiec J., Connell, B.O., Wellner, R., Zhu, X.,

& Ambudkar, I.S (2000). TRPC1 a candidate protein for the store-operated Ca2+ influx Mechanism in salivary gland cells. Journal of Biological Chemistry. 275; 3403-3411. *both contributed equally

75. Curdt, I., Singh, B.B., Jakoby, M., Hachtel, W & Böhme, H (2000). Identification of amino acid

residues of nitrite reductase from Anabaena sp. PCC 7120 involved in ferredoxin binding. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1543; 60-68.

76. Varma A., Singh B.B., Karnani N., Lichtenberg, H., Hoefer M., Magee B.B. & Prasad R. (2000).

Molecular cloning and functional characterization of a glucose transporter, CAHGTI, of Candida albicans. FEMS Microbiology letters.182; 5-21

77. Liu, X., Singh, B.B & Ambudkar, I.S (1999). ATP-dependent activation of KCa and ROMK-type

KATP channels in human submandibular gland ductal cells. Journal of Biological Chemistry. 274; 25121-25129.

78. Singh, B.B., Patel, H.H., Ropeman, R., Schick, D. & Ferreira, P.A. (1999). The Zinc finger cluster

domain of RanBP2 is a specific docking site for Nuclear Export Factor, Exportin-1. Journal of Biological Chemistry. 274; 37370-37378.

79. Singh, B.B., Curdt, I., Jakobs, C., Bisen, P.S. & Böhme, H (1999). Identification of amino acids

responsible for oxygen sensitivity of ferredoxins from Anabaena variabilis using site-directed mutagenesis Biochimica et Biophysica Acta (BBA) - Bioenergetics.1412; 288-294.

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80. Sengupta, L.K., Singh, B.B., Mishra, R., Pandey, P.K., Singh, S., Sengupta, S. & Bisen, P.S (1998). Calcium- dependent metabolic regulations in prokaryotes indicate conserved nature of calmodulin gene. Indian Journal of Experimental Biology. 36; 136-147.

81. Singh, B.B, S. Singh and P.S. Bisen (1998). why does diazotrophic cyanobacterium in its

immobilized state liberate ammonium? (Ed.) V.K. Jain Wisdom Publishing House. New Delhi 352-358.

82. Bisen, P.S; Singh, B.B; Sengupta, L.K; Mishra, R; Sengupta, S; Pandey, P.K & Singh, S (1997).

Calcium- calmodulin: An overview with reference to microbes In: Microbiological Prospects and Applications (edited by A. Varma) IBH & Oxford Publications. New Delhi. pp 125-137.

83. Singh, B.B., Pandey, P.K., Singh, S. & Bisen, P.S (1997). Calcium-induced physiological and

biochemical changes in the cyanobacterium Nostoc MAC. Indian Journal of Experimental Biology. 35; 881-885.

84. Singh, B.B., Pandey, P.K., Singh, S. & Bisen, P.S (1996). Evidence for the nitrate assimilation

dependent nitrite excretion in cyanobacterium Nostoc MAC. World Journal of Microbiology and Biotechnology. 12; 285-287.

85. Singh, B.B., Pandey, P.K., Singh, S, & Bisen, P.S (1996). Regulation of nitrate uptake and nitrite

efflux in the cyanobacterium Nostoc MAC. Journal of Basic Microbiology. 36; 433-438 86. Singh, B.B., Pandey, P.K., Singh, S. & Bisen, P.S. (1996). Calcium/calmodulin antagonist-induced

changes in the cyanobacterium Nostoc MAC. Physiology & Molecular Biology of Plants. 2; 75 - 78.

87. Pandey, P.K., Singh, B.B., Mishra, R. & Bisen, P.S. (1996). Ca2+ uptake and its regulation in the

cyanobacterium Nostoc MAC. Current Microbiology. 32; 332-336. 88. Singh, S., Singh, B.B. & Bisen, P.S. (1995). Copper-induced changes in the urea uptake and urease

activity in the cyanobacteria Anabaena doliolum and Anacystis nidulans: Interaction with sulfur containing amino acids. Biomedical and Environmental Science. 8: 158 - 163.

89. Pandey, P.K., Singh, B.B., Singh, S. & Bisen, P.S. (1995). NO2

- efflux and its regulation in the cyanobacterium Nostoc MAC Current Microbiology. 31; 119 -123.

90. Singh, S., Singh, B.B., & Bisen, P.S. (1995). The role of ammonium assimilation in the urea

inhibition of nitrogenase activity in cultured cyanobiont Nostoc ANTH. Indian Journal of Experimental Biology. 33; 33 -39.

91. Singh, S., Singh, B.B., & Bisen, P.S. (1994). The role of membrane potential in ammonium

inhibition of nitrogenase activity in the cultured cyanobiont Nostoc ANTH. World Journal of Microbiology & Biotechnology (Rapid communication of Oxford Ltd. U.K). 10; 600.

Communicated/In preparations

• Pramod Sukumaran, Yuyang Sun, Neil Antonson, and Brij B Singh (2017) Neurotoxin-mediated inhibition of NFκB attenuates TRPC1 expression that blocks autophagy to induce dopaminergic cell death. Journal of Biological Chemistry. (minor revision)

• Yuyang Sun, Senthil Selvaraj, Jamie Foster, Min Wu, John A Watt, Joyce Ohm and Brij B Singh (2017) BDNF induced differentiation of mesenchymal stem cells to dopaminergic neurons to exhibit increased sensitivity to MPP+ by inhibiting Ca2+ influx. Scientific Report.

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• Pani, B., Sun, Y., Bollimuntha, S., Ambudkar, IS and Singh, B.B. (2017) Ca2+ entry via Orai1 is essential for plasma membrane retention and functional activation of TRPC1 channels. In preparation for the Journal of Biological Chemistry.

• Ohm, J., Mishra, B.B., Wong, D., Vissink, A, Ambours, J., and Brij B Singh (2017). Epigenetic-

mediated loss of alpha-1 antitrypsin is essential for Sjögerns syndrome. In preparation for the Journal of Immunology.

• Bollimuntha, S., Pani, B Sun, Y., Mori, Y and Singh, B.B. (2017) Activation-induced TRPC3

exocytosis and association with SNARE proteins facilitates hormone secretion. In preparation for Brain.

• Selvaraj, S., Combs, C., and Singh, B.B. (2017) TRPC3 regulates Abeta-mediated calcium entry in

neuronal cells: A possible role of TRPC3 in Alzheimer disease. (In preparation for Journal of Neuroscience).

• Bollimuntha, S., Watt, J., Lei, S., and Singh, B.B (2017) TRPC3 regulates exocytosis and

vasopressin release from pituitary gland. In preparation for Nature Neuroscience.

Abstract Presented (National and International Meetings? (Stopped adding after 2010). 1. Sunitha Bollimuntha, John A Watt, and Brij B Singh “TRPC3 –VAMP2 interaction mediates

neurosecretion” at IIIrd Biennial national IDeA symposium of Biomedical Research Excellence, Washington DC June 2010.

2. Senthil Selvaraj and Singh, B.B “TRPC1 regulates apoptotic cell degeneration induced by the

dopaminergic neurotoxin MPTP” at IIIrd Biennial national IDeA symposium of Biomedical Research Excellence, Washington DC June 2010.

3. Sunitha Bollimuntha, John A Watt, Sabao Lie, and Brij B Singh “TRPC3 –VAMP2 interaction

mediates neurosecretion” at ND-COBRE symposium, Fargo, ND Feb 2009. 4. Senthil Selvaraj and Singh, B.B “TRPC1 regulates apoptotic cell degeneration induced by the

dopaminergic neurotoxin MPTP” at IInd Biennial national IDeA symposium of Biomedical Research Excellence, Washington DC August 2008.

5. Sunitha Bollimuntha, John A Watt, and Brij B Singh “TRPC3 and neurosecretion” at IInd

Biennial national IDeA symposium of Biomedical Research Excellence, Washington DC August 2008.

6. Pani, B., Ong, H.L., Brazer, S-C., Liu, X., Ambudkar IS., and Singh, B.B Scaffolding of TRPC1

by Caveolin1 is required for STIM1-mediated channel clustering and activation at Calcium Signaling, FASEB summer conference, Colorado, July 2008.

7. Biswaranjan Pani, Xibao Liu, Indu Ambudkar, and Brij B Singh. “Activation dependent

recruitment of STIM1 onto membrane rafts relieves Cav1 suppression of TRPC1 function” Calcium Signaling Gordon Conference July 2007.

8. Sunitha Bollimuntha, John A Watt, and Brij B Singh “Role of TRPC3 channel in

neurosecretion” Calcium Signaling Gordon Research Conference, July 2007. 9. Yassin Labyed, Naima Kaabouch, Richard R. Schultz, and Brij B Singh, “Gel electrophoresis

image segmentation and band detection based on the derivative of the standard deviation,” Proceedings of the International Conference on Artificial Intelligence and Pattern Recognition, pp. 31-35, 2007.

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10. Biswaranjan Pani, Xibao Liu, Indu Ambudkar, and Brij B Singh “Compartmentalization of TRPC1-STIM1 interactions into lipid raft domains” FASEB J, April 2007.

11. Sunitha Bollimuntha, John A Watt, and Brij B Singh “The Potential Role of TRPC3-VAMP2

Interaction in Neurosecretion” FASEB J, April 2007. 12. Yassin Labyed, Naima Kaabouch, Richard R. Schultz, and Brij B Singh, “Automatic

segmentation and band detection of protein images based on the standard deviation profile and its derivative,” IEEE Electro/Information Technology Proceedings, ISBN: 1424409411, pp 669-673, 2007

13. Biswaranjan Pani, Xibao Liu, Indu Ambudkar, and Brij. B. Singh “TRPC1, STIM1 localization

in lipid rafts is essential for store-operated calcium entry at Salivary gland and exocrine secretion” 11-16 February 2007.

14. Sunitha Bollimuntha and Brij B Singh “TRPC1 mediated protection of human SH-SY5Y

neuroblastoma cells by MPP+ and salsolinol” 4th Neuroscience symposium, School of Medicine, Grand Forks December 1st 2006.

15. Jara, H Javier, Brij B Singh, Colin K Combs. “Tumor necrosis factor alpha potentiates NMDA

receptor-dependent neuron death in an age-dependent fashion in vitro”. Neuroscience meeting (Society for Neuroscience).

16. Liu X, Singh B, Cheng O, Bandyopadhyay B, Nakamoto T, Liedtke W, Melvin JE, Birnbaumer

L, and Ambudkar I. The role of TRP channels in the salivary gland fluid secretion. Poster G6, 3rd International Symposium on Salivary Glands, Okazaki, Japan, 20-24 October 2006.

17. Biswaranjan Pani and Brij. B. Singh “TRPC1 and STIM1 get on the lipid raft to surf away

from the calcium waves” at the Basic Sciences Graduate Program Retreat, School of Medicine, Grand Forks Sep 25th, 2006.

18. Sunitha Bollimuntha., John Watt., and Brij B Singh “A potential role of TRPC3 in

Neurosecretion” at Basic Sciences Graduate Program Retreat, School of Medicine and Health Sciences, Grand Forks, ND Sep 25th, 2006.

19. Sunitha Bollimuntha and Brij B Singh “TRPC1 protects dopaminergic neurons against toxins

causing Parkinson Disease” at Ist Biennial national IDeA symposium, July 2006. 20. Jara, J.H, Brij B Singh, Floden, A.M, and Combs, C.K. “Tumor necrosis factor alpha

stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death” at Ist Biennial National IDeA Symposium, July 2006.

21. Biswaranjan Pani, Eric Cornatzer, Brij. B. Singh “Upregulation of TRPC1 following

SERCA2 gene silencing promotes cell survival: A Potential role of TRPC1 in Darier’s Disease” at 2006 North Dakota Academy of Sciences, Valley City, North Dakota. April 2006.

22. Sunitha Bollimuntha., John Watt., and Brij B Singh “The potential role of TRPC3-VAMP2

interaction in neurosecretion” at FASEB (ASBMB) meeting, San Francisco. June 2006. 23. Biswaranjan Pani, Eric Cornatzer, Brij. B. Singh “Functional link of TRPC1 calcium

channel in Darier’s Disease” at 2006 Scholarly Forum (graduate School), University of North Dakota, Grand Forks. March 2006.

24. Combs, C.K., Brij. B. Singh, and Floden, A.M “Tumor necrosis factor alpha stimulates

NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death” at the Society for Neuroscience meeting, Washington DC. November 2005.

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25. Bidhan C. Bandyopadhyay, Brij B. Singh, Hwei L. Ong, Xibao Liu, Randen L. Patterson, and Indu S Ambudkar “A Role for RACK1 in the assembly of the TRPC3-IP3R signaling complex” organized by Gordon Calcium Signaling, Cambridge, UK, July 2005.

26. Sunitha Bollimuntha, Shaik Shavali, Sushil K Sharma, Manuchair Ebadi and Brij B Singh

“TRPC1 mediated protection of dopaminergic neurons against toxins causing Parkinson Disease” at the Aging and human disease, Spineto Abbey, Italy, organized by Cell press. November 2004.

27. Eric W Cornatzer., William E Cornatzer, Ashley K Bansal., Brij B Singh “Calcium influx via

Transient Receptor Potential protein 1 is required for Darier’s disease” presented at the North Dakota EPSCoR conference, Fargo, ND, 2004.

28. Sunitha Bollimuntha. and Brij B Singh “VAMP2 mediated activation and exocytosis of

TRPC3 Ca2+ channel” presented at CIHR National Health Research Poster Competition, Winnipeg. Canada, June 8th, 2004.

29. Sunitha Bollimuntha, and Brij B Singh “TRPC1 mediated protection of human SH-SY5Y

neuroblastoma cells by MPP+ and salsolinol” Basic Sciences Graduate Program Retreat, School of Medicine, Grand Forks Sep 25th 2004.

30. Cornatzer, E., Duppong, T., Bansal., A., and Singh, B.B “Self-assembly of TRPC1 and

TRPC3 is mediated via the first ankyrin domain” presented at the North and South Dakota EPSCoR joint conference, Fargo, ND, 2003.

31. Singh, B.B., Liu, X, Combs, C., Ambudkar S.V., and Ambudkar, I.S. “Evidence for VAMP2 involvement and exocytosis in the plasma membrane localization of TRPC3 protein” presented at the 42nd American society for Cell Biology, San Francisco, CA, 2002.

32. Singh, B.B., Liu, X, and Ambudkar., I.S. “Calmodulin regulates Ca2+ dependent feedback

inhibition of store-operated influx by interaction with a site in the C-terminus of TRPC1” presented at the Experimental Biology, annual meeting, New Orleans, Louisiana

33. Ferreira P.A., Yunfei, C, and Singh, B.B “The Ran-binding protein 2, a signal integrator of

nucleocytoplasmic trafficking pathways”. Presented at the Experimental Biology, annual meeting, Orlando, Florida, 2001.

34. Ferreira P.A., Singh, B.B., Yunfei, C. and Fauser, S “The RanBP2 protein machine: piecing

together the puzzle of components of a novel macromolecular assembly complex”. Presented at the 40th American society for cell Biology, Annual Meeting, San Francisco, CA, 2000.

35. Ferreira P.A., Patel, H.H., Schick, D, and Singh, B.B. “Structure-Function analysis of

RanBP2 protein machine”. Presented at the American Society for Biochemistry and Molecular Biology, International meeting, held in Boston, Massachusetts, 2000.

36. Ferreira P.A., Singh, B.B., Patel, H.H., Schick, D., and Ropeman, R. “The Zinc finger cluster

domain of RanBP2 is a specific Docking Site for the Nuclear Export Factor, Exportin-1”. Presented at the Association for Research in Vision and Ophthalmology (ARVO), Annual meeting, held in Fort Lauderdale, Florida, 2000.

37. Singh B.B; Pandey P.K; Mishra R; Singh S. and Bisen P.S. “Calcium uptake by free

immobilized cells of the cyanobacterium Nostoc MAC”. Presented at the XIX All India Cell Biology Conference, Calcutta, India 1996. Abs. No.38.

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38. Pandey P.K; Singh B.B; Mishra R; & Bisen P.S. “Calcium-induced changes in selected photo chemical reactions in the cyanobacterium Nostoc MAC”. Presented at the 4th International Symposium in Biological Metals at Universitat Ravirai Vergili Spain, 1996.

39. Pandey P.K; Singh B.B; Singh S & Bisen P.S. “Immobilization leads to ammonium liberation

in the cyanobacterium Nostoc MAC”. Presented at the 10th International Congress on Nitrogen Fixation at St. Petersburg Russia, 1995.

40. Pandey P.K; Singh B.B & Bisen P.S. “Investigation on heavy metal resistance/tolerance in the

cyanobacterium Nostoc calcicola”. Presented at the International Conference on Biotechnology Research & Application for Sustainable Development at Chulabhorn Research Institute Thailand, 1995.