CURRICULUM VITAE

Kenneth Laurence Tyler, M.D.Louise Baum Endowed Chair & Chairman, Department of Neurology

University of Colorado School of MedicineNeurology Mail Stop B-182

Research Complex -212700 East 19th Avenue

Aurora, Co 80045303-724-4327

Ken.Tyler@ucdenver.edu

Education:

1971 The Noble and Greenough School, Dedham, MASumma Cum Laude

1974 A.B., Harvard University, Cambridge, MAMagna Cum Laude

1978 M.D., The Johns Hopkins University School of Medicine, Baltimore, MD

Internship and Residencies:

1978-l980 Intern and Resident, Internal Medicine, Peter Bent Brigham Hospital, Boston, MA

1980-1983 Neurology Resident,

Massachusetts General Hospital, Boston, MA

1982-1983 Chief Resident, Neurology, Massachusetts General Hospital, Boston, MA

Research Fellowships:

1983-1984 Research Fellow, Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA

Other Training:

2004 Program for Chiefs of Clinical Services, Harvard School of Public Health, Boston, MA

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Academic Appointments:

1978-1980 Clinical Fellow (Medicine), Harvard Medical School

1980-1983 Clinical Fellow (Neurology), Harvard Medical School

1983-1984 Research Fellow (Microbiology and Molecular Genetics), Harvard Medical School

1983-1985 Research Fellow, Muscular Dystrophy Association, Department of Microbiology and Molecular Genetics, Harvard Medical School

1984-1986 Instructor in Microbiology and Molecular Genetics, Harvard Medical School

1986-1991 Assistant Professor of Neurology (Neuroscience), Harvard Medical School

1991-1995 Associate Professor of NeurologyAssociate Professor of Medicine, Microbiology, ImmunologyUniversity of Colorado Health Sciences Center

1995- Professor of Neurology (tenured)

Professor of Medicine, Microbiology, ImmunologyUniversity of Colorado Health Sciences Center

1997-2000 Vice-Chairman, Dept. of Neurology University of Colorado Health Sciences Center 1998-1999 Acting Chair, Dept. of Neurology

University of Colorado Health Sciences Center

2001-2017 Reuler-Lewin Family Professor of Neurology

2017- Louise Baum Endowed Chair in Neurology

2009- Chair, Department of Neurology, University of Colorado School of Medicine

2010- Co-Director, University of Colorado School of MedicineNeuroscience Center (UCNS)

Hospital Positions:

1983-1986 Clinical Assistant in Neurology, Massachusetts General Hospital

1986-1991 Assistant Neurologist, Massachusetts General Hospital

1991- Physician, Neurology Service, VA Medical Center, Denver, CO

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1994-1995 Acting Chief, Neurology Service, VA Medical Center, Denver, CO 1995-2009 Chief, Neurology Service, VA Medical Center, Denver CO

2009-present Chair, Neurology University of Colorado Hospital (UCH)Member, Medical Board, University of Colorado Hospital (UCH)Member, Board of Directors, University Physicians Inc. (UPI)/CU Medicine

Other Professional Positions:

1982-1987 Consultant in Neurology, Massachusetts Rehabilitation Commission

1993- Member, University of Colorado Cancer Center

1993- Graduate Faculty, Depts. Microbiology, Immunology, Univ. Colorado Health Sciences Center 1993- Faculty, Medical Scientist Training Program (MSTP)

Univ. Colorado Health Sciences Center

1998- Faculty, Biomedical Sciences Program Univ. Colorado Health Sciences Center

1999- Member, Neuroscience Program and Center Univ. Colorado Health Sciences Center

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Honors & Awards:

1978 Phi Beta Kappa

1978 Alpha Omega Alpha Honor Medical Society

1983 S. Weir Mitchell Award, American Academy of Neurology

1983-1985 Muscular Dystrophy Association Research Fellowship

1984-1989 Physician-Scientist Award, National Institute of Allergy and Infectious Disease

1986-7 William F. Milton Fund Research Fellow,

Harvard University

1986-1990 Alfred P. Sloan Foundation Research Fellow

1988 Visiting Professor, Department of Neurology,University of Alabama School of Medicine

1990 Visiting Professor, Department of NeurologyMedical University of South Carolina

1991 Science College, Concordia University, Public Lecture Series, Montreal, Canada

1997 Rhea & Louis Boshes Visiting ProfessorDept. Neurology, Northwestern University School of Medicine

1997 Elected to membership, American Society for Clinical Investigation (ASCI)

1998 Visiting Professor, Department of Medicine (Neurology)Duke University School of Medicine

1999-current Who’s Who in America® (2000 et seq, latest 2011, Marquis Who’s Who)

2000 Lawrence McHenry Jr. Award, American Academy of Neurology

2001-current Best Doctors in America, 2001-current (http://www.bestdoctors.com)

2002 5th Landau Lecturer, Washington University School of Medicine, St. Louis, MO.

2004 Julius Brendel Trust Visiting Professor, Auckland, New Zealand

2004 Inaugural Walter Friedlander Lecturer, University of Nebraska School of Medicine, Omaha, NE

2004 WT Connell Memorial Professor, Queens University, Ontario, Canada

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2006-2008 Chair, National Institute’s of Health (NIH) Clinical Neuroimmunology & Brain Tumors Study Section (CNBT) (thru June 2008)

2007, 2008 America’s Top Physicians, Guide to America’s Top Physicians, Consumers Research Council of America, (http://www.consumersresearchcncl.org)

2007 Fellow, American Association for the Advancement of Science

2007 Elected to membership, Association American Physicians (AAP)

2010 25th Andrew Mark Lippard Lecturer, Columbia University School of Medicine, NY, NY

2011, 2012 U.S. News and World Report, Top Doctors (Neurologists)

2012 Fellow, American Academy of Microbiology

2012 40th Robert B. Aird Professor, Dept. Neurology UCSF, San Francisco, CA

2014 Elected, Henry Kunkel Society, Rockefeller University

2017 4th Visiting Professor, University of Texas Medical Branch, Galveston, TX

2018 Richard Paine Lecturer, Children’s National Medical Center, Center for Neuroscience & Behavioral Medicine, Washington, DC

2018 Inaugural H. Richard Tyler Lecturer, Neurology Dept. Brigham & Womens Hospital, Boston, MA

Memberships, Offices and Committee Assignments in Professional Societies:

1979 (Member)- American College of Physicians (ACP) 1990 Fellow 1980- American Federation for Medical Research (AFMR)

1981 (Member)- American Academy of Neurology (AAN) 1987 Fellow

Annual Meeting Scientific Program Chair or Co-Chair:Neurochemistry (1985), Neurovirology (1986-7,1989, 1991, 1993), History of Neurology (l990-95, 2001, 2002), Infection & AIDS (1996, 1997, 2000), CNS Infections (1999), NeuroAIDS (1999), Infections/AIDS/Prions (2004-6), Topic Chair: Infections/AIDS/Prions 2005-8

History Section: Secretary 1987-89; President 1989-91, Executive Committee 1996-99

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Member, Scientific Issues/Program Committee, 1989-1997Member, Scientific Program Subcommittee 2005-2008Chair, McHenry Award Subcommittee, 1989-1994Member, Awards Policy Task Force, 1993-1997 Member, Foundation Research Award Subcommittee, 1994-98;

Chair, 1999-2001Chair, Membership Committee, 2001-2005Councilor, Neuro-Infectious Disease Section, 2003-5, 2006-8Member, Leadership Task Force 2005-6Member, Neuro-infectious Disease Expert Review Advisory Panel 2017-

Director, (AAN Board of Directors) 2003-2007

1982- American Society for Neurological Investigation;Secretary-Treasurer, 1983-1984; President, 1984-l985;Co-Chairman Annual Symposium: Viruses and theNervous System: Molecular Aspects and Pathogenesis, 1985

1984- American Society for Microbiology (ASM)Fellow, American Academy of Microbiology (2012)

1984-1991 Boston Society of Psychiatry and Neurology

1985- American Society for Virology (ASV)Symposium Speaker, 11th Annual Meeting (1992)Convenor, 13th Annual Meeting (1994), Viral Immunology WorkshopConvenor, 17th Annual Meeting (1998), Viral Pathogenesis WorkshopConvenor, 21st Annual Meeting) (2002). Viral Pathogenesis WorkshopProgram Committee (2004-2006)

1988- Society for Experimental NeuropathologyCouncilor, 1996-1999

1991- Society for Neuroscience; Neurobiology of Disease Workshop Organizing Committee (1991) Committee on the History of Neuroscience (1993)

1991- American Neurological Association (ANA) (fellow)Treasurer/Board of Directors (2014-)Council/Board of Directors (2011-14)Scientific Program Committee (2006-2009)Long Range Planning Committee (1999-2000)(2004-2005)History of the Association Committee (2001-2002)

1992- Colorado Society of Clinical NeurologistsSecretary Treasurer, 1993-1995

1992- Association of VA NeurologistsCouncilor, 1996-1998

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1997- American Society for Clinical Investigation

2000- International Society for NeurovirologyBoard of Directors, 2017-

2003- Infectious Disease Society of America (IDSA)Fellow

2007- Fellow, American Association for the Advancement of Science (AAAS)

2007- Association of American Physicians (AAP)

2011 International Advisory Board, XVth International Congress of Virology, Sapporo, Japan (2012)

2012- Fellow, American Academy of MicrobiologySteering Committee, West Nile Virus Colloquium (2013)

2013 International Advisory Program Committee, XVIth International Congress of Virology (Montreal, Quebec, 2014).

2014- Henry Kunkel Society of Rockefeller University

2014-2017 Association of University Professors of Neurology (AUPN), Executive Council

Selected Major Committee Assignments and Study Sections:

1986-1990 Neurology Clerkship Committee (New Pathway Project)Harvard Medical School

1989 Institute of Medicine (IOM), National Academy of SciencesResearch Briefing Panel on the Molecular Biology of Microbe-Host

Interaction (consultant)

1992-1995 National Multiple Sclerosis Society, Scientific Advisory Committee (fellowships)

1993 Ad Hoc reviewer: Visual Sciences C Study Section, NIH

1994 Ad Hoc reviewer: NINDS NSP-B (Program Projects) Committee, NIH

1994,1999 Ad Hoc reviewer: Dept. Veterans Affairs Merit Review Board 1996 Special reviewer: Experimental Virology (EVR) Study Section, NIH

2000-2004 Member, Medical Advisory Research Group (MRAG) (Neurological and Sensory Disorders), Dept. of Veterans Affairs

2000 NIAID Division of Microbiology & Infectious Diseases, Neurotropic Viruses Blue Ribbon Panel

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2001 Board Examiner, American Board of Psychiatry and Neurology (Neurology)

2001 External Reviewer, Institut Pasteur, Structures de Recherche (Unite de

Biologie Moleculaire de l’Expression Genique) Paris, France

2003 NIH/NIAID Neurology Advisory Group for West Nile Virus

2003 External Reviewer, Institut Pasteur, L’Evaluation Scientifique, Paris. France

2003 Temporary Member, Experimental Virology (EVR) Study Section, NIH

2004 Member, Special Emphasis Panel, ZRG1 (Neurovirology), Experimental Virology (EVR) Study Section, NIH

2004-2006 Regular Member, Clinical Neuroimmunology and Brain Tumors Study Section (CNBT, Formerly BDCN-4), Study Section, NIH.

2006-2008 Chair, NIH CNBT (Clinical Neuroimmunology & Brain Tumors) Study Section

2007 Member, NIH Special Emphasis Panel, ZRG1 IDM-R 02 (Pathogenic

Viruses) 2008 Member, NIH Special Emphasis Panel, ZRG1 IDM-B (02) (Viral

Pathogens)

2008 Reviewer, NIH Director’s New Innovator Awards

2008 Member, NIH Special Emphasis Panel, ZAG1 ZIJ-2 (05)(Aging and Disease)

2009 Reviewer, NIH Special Emphasis Panel, ZRG1 IMM-E(58)R (Immunologic Sciences)

2010 Reviewer, NIH Special Emphasis Panel, ZRG1 BDCN-Y (02) M, (Neurodegenerative Disorders)

2010 Board of Scientific Counselors, NINDS (Ad Hoc Reviewer)

2010- Scientific Advisory Board, PML Consortium, Washington DC

2011 Welcome Trust (London, UK), External Peer Reviewer (Senior Investigator Awards)

2011 Temporary Member, VIRA (Virology A) Study Section, NIH

2011 Member, ZRG1 BDCN-L(52)R, US-India Bilateral Brain Research Collaborative Partnership Special Emphasis Panel

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2011, 2012 Temporary Member, Neurobiology C (NURC) Study Section, Department of Veterans Affairs

2013-2015 Alpha Omega Alpha Student Research Fellowship Reviewer

2013 Member, ZA/1LGR-M(S1), NIAID Clinical Trials Planning and Implementation Grants Special Emphasis Panel

2013 NIH Center for Scientific Review (CSR) Advisory Council

(External Review Committee for Evaluation of Infectious Diseases and Microbiology (IDM) Integrated Review Group Study Sections)

2013 Reviewer, Efficacy and Mechanism Evaluation Program, Medical Research Council (MRC). National Institute for Health Research/National Health Service, United Kingdom

2014, 2015 Member (Temporary), NINDS Neurological Sciences and Disorders C (NSD C) Study Section

2014 Center for Zoonotic and Emerging Infectious Diseases, Montana State University, pilot project reviewer (COBRE-NIH NIGMS Centers for Biomedical Research Excellence)

2015 Member, ZAI1-JKB-M-M1, NIAID Clinical Trials Planning Special Emphasis Panel

2015 Organizing Committee, 12th International double-stranded RNA virus symposium, Goa, India

2015 Center for Disease Control (CDC), Acute Flaccid Myelitis, Clinical Management Expert Workgroup

2016 Center for Disease Control (CDC). Botulism Clinical Guidelines Treatment Workgroup

2016 Member, ZRG1 MDCN-C (02)M, Neurodevelopment and Function Special Emphasis Panel

2016 Chair, ZNS1 SRB-A (02), Rapid assessment of Zika virus complications Special Emphasis Panel

2017- American Brain Foundation Expert Review Panel (Neuroinfectious Disease)

2017 Temporary Member, CNBT (Clinical Neuroimmunology & Brain Tumor) Study Section, NIH

2017 Reviewer, US Army Medical Research & Materiel Command, Peer-reviewed Medical Research Program (PRMRP), Discovery-Autoimmune Disorders

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2017 Chair, ZRG1 BDCN-Q(90)S, Neurovirology and Neurodevelopmental aspects of Zika virus infection

1991-current Denver VA Medical Center:

Biosafety Subcommittee (1991-2), Animal Studies Subcommittee (1992-3), Space and Resources Subcommittee (1993-97), Research and

Development Committee (1992-5), Mental Health (Psychiatry) Chief Search Committee (2001), Clinical Executive Board (1992-2009), Professional Standards Board (1992-2009), Chair, Medical Service Chief Search Committee (2006), Member ACOS (Research) Search Committee (2008), Neurology Chief Search Committee (2017)

University of Colorado HospitalMedical Board (2009-), Member, Resource Management Committee (2009-2015), Co-Chair, Neuroscience Strategic Planning Committee (2009-),

1991-current University of Colorado School of Medicine (UCSOM):Residency Selection Committee, Neurology Department, (1992-1999, 2001-current); Faculty Senate (1993-5); Chairman, Faculty Promotions Committee, Neurology Department (1996-2009);

Member, Pediatric Neurology Chief Search Committee, UCSOM andThe Children’s Hospital (1999, 2006); Chair, Neurosurgery Chair Search Committee (1999); Member, Search Committee, Chief of the Division of Infectious Disease (Department of Medicine)(2004, 2013); Dean’s Strategic Initiative Research Committee (SIRC) 2006-9 (Chair 2008-2009). Co-Chair Neuroscience Committee for Sch. Medicine Strategic Research Retreat (2009). Member Review Committee, Dept. of Dermatology (2012). Member Dean’s Executive Committee (2009-), UPI Audit & Finance Cmte (2013-14, UPI Finance Cmte (2014-2016), UPI Strategy Committee (2014-), Member Review Committee Department of Pediatrics (2014), Member Review Committee Department of Physical Medicine & Rehabilitation (2016). Member, Search Committee, Chair of Dept. of Immunology-Microbiology UCSOM (2016).

Licensure and Board Certification:

1979 National Board of Medical Examiners

1980 Massachusetts License Board of Registration and Discipline in Medicine

1983 American Board of Internal Medicine

1984 American Board of Psychiatry and Neurology

1991 Colorado License

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Colorado State Board of Medical Examiners

Review and Referee Work:

Editorial Boards:

(COMPLETED) 1990-1997 Journal of the Neurological Sciences

(Associate Editor)

1993-1997 Journal of the History of Neuroscience

1992-1997 Journal of Virology 2005-2010 1996-2002 Lancet Neurology Network (Previously: Neurology Network Commentary, Sid Gilman, M.D., Editor)

1998-2000 Current Treatment Options in Neurology (Section Editor, CNS Infections)

2005-2007 European Journal of Neurology 2004-9 Reviews in Neurological Disease

2003-2010 Neurology

1997-2013 Archives of Neurology 2015 Current Opinion in Neurology (Editor: Inflammatory Diseases &

Infection, vol. 28(3), June 2015)

2009-16 Annals of Neurology

2009-17 Neurology Today (AAN Publication, Associate Editor)

(ACTIVE) 1990- Microbial Pathogenesis

1995- Journal of Neurovirology(Senior Associate Editor, 2006-)

2002- Apoptosis

2003- Experimental Neurology

2003- Journal of Infectious Disease

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2005- Virology

2013- JAMA Neurology

2016- Neurology

2017 PLoS Pathogens (Guest Editor)

2018- Annals of Neurology

Ad Hoc reviewer for the following additional journals:

American Journal of Tropical Medicine & Hygiene, Annals of Clinical & Translational Neurology, Annals Internal Medicine, Archives of Physical Medicine & Rehabilitation, Annals of Tropical Pediatrics, BMC Infectious Diseases, BMC Veterinary Research, Brain, Brain Research, Breast Cancer Research, Cellular Microbiology, Clinical Infectious Diseases, Diabetologia, Emerging Infectious Diseases, Epilepsia, European Journal of Clinical Microbiology & Infectious Diseases, Gene Therapy, Herpes Journal, Infections in Medicine, Journal of Acquired Immunodeficiency Syndromes, JAMA, Journal of Clinical Investigation, Journal of Clinical Virology, Journal of Experimental Medicine, Journal of Neuroimmunology, Journal of the Neurological Sciences, Journal of Neurology Neurosurgery & Psychiatry, Journal of Neuropathology & Experimental Neurology, Journal of Virology, Laboratory Animal Science, Lancet, Lancet Infectious Disease, Lancet Neurology, MBio, Muscle & Nerve, Nature Clinical Practice in Neurology, Nature Immunology Reviews, Nature Medicine, Neurology Clinical Practice, Neuropsychologia, New England Journal of Medicine, Pediatric Infectious Disease, PLos One, PLoS Pathogens, Proceedings National Academy Sciences, Science, Respiratory Cell and Molecular Biology, Science Translational Medicine, Veterinary Microbiology, Viral Immunology, Virus Research

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Selected Invited Extramural Lectures, Grand Rounds, Seminars, Symposia:

International

1985 XIIIth World Congress of Neurology, Symposium on Neurovirology (RT Johnson, Chairman) "Viral Genes and Neurotropism"

1991 Neurology Grand Rounds, Montreal General Hospital

1991 Colloquium Series: Psychology Dept., Science College Concordia University, Montreal

1991 Public Lecture Series, Science College, Concordia University, Montreal

1993 Chairman, Symposium on the History of Neurology, XVth World Congress of Neurology, Vancouver, B.C.

1996 Plenary Speaker, XVIIth Brazilian Congress of Neurology, Curitiba, Brazil

1998 Symposium Speaker, New Aspects of the Diagnosis of Viral Infections of the CNS, Klinik fur Psychaitrie und Klinik fur Neurologie der Friedrich-Schiller-Universitat, Jena, Germany

1998 Symposium Speaker, Mansell Bequest Symposium, 225th Anniversary of the Medical Society of London, England

1998 Convenor, Workshop on Viral Pathogenesis, American Society for Virology 1998 Annual Meeting, Vancouver, Canada

2000 Department of Virology, Institut Pasteur, Paris, FranceMechanisms of virus-induced apoptosis in vitro and in vivo: insights from the reovirus system.

2000 7th International Symposium on Double-Stranded RNA Viruses (invited plenary speaker), Aruba

2003 10th Annual Meeting, International Herpesvirus Management Forum, Paris, France (invited speaker). Herpes simplex virus meningitis.

2003 Seminar Speaker, Departement de Virologie, Institut Pasteur, Paris, France

2003 Guest Lecturer, Institut Paul Broca (INSERM) and Departement de Neurologie, Hopital de St. Anne, Paris, France

2004 24th WT Connell Memorial Lecture, Queens University, School of Medicine, Kingston, Ontario, Canada (West Nile encephalomyelitis)

2004 John Austin Society Lecture, Queens University, School of Medicine, Kingston, Ontario, Canada (Development of ideas on cerebral localization)

2004 Seminar Speaker, Department of Microbiology & Immunology, Queen’s

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University, Kingston, Ontario, Canada (Reovirus-induced apoptosis)

2004 Seminar Speaker, Cancer Biology Research Group, University of Calgary, Calgary, Canada

2004 Grand Rounds, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada

2006 Neurology Grand Rounds, Neurolgische Klinik und Poliklinik, Universitatsklinikum Wurzburg, Germany

2006 Seminar, Departement de Biologie Cellulaire et Morphologie (DBCM) and the Departement de Physiologie, Universite de Lausanne, Switzerland

2008 Chair, Symposium on Reo, rota, and orbiviruses. XIVth International Congress of Virology, Istanbul, Turkey, Aug 10-15, 2008

2008 Speaker, Infectious diseases of the nervous system: pathogenesis and worldwide impact (conference), Pasteur Institute, Paris

2009 Speaker, 6th Hong Kong University Pasteur Institute -Virology Course, Hong Kong University-Pasteur Research Center, Hong Kong, China

2010 Plenary Session Discussant, Contemporary Clinical Issues & Case Studies Plenary Session, 61st Annual Meeting, American Academy of Neurology, Toronto, Canada

2012 Keynote Speaker, Emerging Zoonotic Viral Infections of the Nervous System Symposium, Depart. Medical Microbiology, University of Manitoba, Winnipeg, Canada

2012 Plenary Speaker, 11th International Symposium on Double-stranded RNA Viruses, San Juan, Puerto Rico

2015 Second International Conference on PML and JC Virus, Moindal, Sweden

2016 Plenary Speaker, 14th International Symposium, International Society for Neurovirology Annual Meeting, Toronto, Canada

National:

1983 S. Weir Mitchell Lecture, American Academy of Neurology

1985 Neurology Grand Rounds, University of Massachusetts Medical School, "Mollaret's Meningitis."

1986 Consolidated Department of Medicine (Brigham and Women's and Beth Israel Hospital) Molecular Biology Seminar Series, "Molecular and Genetic Basis of Viral Pathogenesis."

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1986 Neurology Grand Rounds, Massachusetts General Hospital, "Pathogenesis of Viral Infection of the Central Nervous System."

1986 Neurology Grand Rounds, Brigham and Women's Hospital, "Pathogenesis of Viral Infections of the Central Nervous System."

1987 American Neurological Association, Presidential Symposium on Viral Infections in the Nervous System, "Molecular and Genetic Aspects of Viral Pathogenesis."

1987 Seminar Speaker, Glaxo Research Laboratories, Chapel Hill, North

Carolina

1988 Reynolds Historical Lecture, University of Alabama School of Medicine

1988 Neurology Grand Rounds, Tufts-New England MedicalCenter, "Molecular and Genetic Basis of Viral Infections of the Nervous System."

1988 UCLA Winter Workshop, "Cellular and Molecular Biology of Neural-Immune Interactions."

1988 Seminar Speaker, Department of Cell Biology, Boston College

1988 Neurology Grand Rounds, Department of Neurology, University of Alabama School of Medicine

1989 Neurology Grand Rounds, Department of Neurology, University of Massachusetts Medical Center

1989 Invited Speaker, 10th Annual Meeting Southeastern Regional Society for Neuroscience

1989 Combined Neurology Grand Rounds and Microbiology/Immunology Seminar, SUNY Syracuse Health Science Center

1989 Neurology-Neurosurgery Grand Rounds, University of Minnesota Medical School

1990 Neurology Grand Rounds, Virology Department Seminar University of Chicago Pritzker School of Medicine

1990 Invited Speaker, Third Carolina Conference on Molecular Neurobiology

1991 Neurology Grand Rounds, Massachusetts General Hospital, Viral Infections of the CNS

1991 Organizer, Neurobiology of Disease Workshop, Virus and Prion Diseases of the Nervous System, Society for Neuroscience, New Orleans,

LA.

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1991 Faculty, Symposium: The Neuron Doctrine 1891-1991 Society for Neuroscience, New Orleans, LA.

1992 Symposium Speaker, Annual Meeting American Society for Virology, Cornell University

1993 Seminar, Department of Microbiology-Immunology, University of North Carolina, School of Medicine, Chapel Hill, N.C.

1993 Seminar, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.

1993 Seminar, Pathogenesis Affinity Group, Scripps Clinic and Research Foundation, La Jolla, CA.

1994 Invited Speaker, Dept. Neurology, Indiana University Medical School and Indiana Neurological Society

1994 Seminar, Dept. Microbiology, Univ. of Pennsylvania School of Medicine

1997 Neurology Grand Rounds (Herpes Simplex Virus Infections of the CNS), Department of Neurology, Thomas Jefferson University, Philadelphia, PA

1997 Fifth Annual Rhea & Louis Boshes Lecture, Dept. Neurology, Northwestern University School of Medicine

1998 Clinical Neuroscience Grand Rounds, Duke University Medical CenterMolecular and genetic basis for viral pathogenesis and virus-inducedCell death

1999 Depts. Molecular Biology & Biochemistry, Microbiology, Molecular Genetics, Seminar Series on Viral Pathogenesis, University of California, Irvine

1999 Abbott Laboratories, Abbott Park, IL, Molecular & genetic basis of virus-induced cell death

2000 4th semi-annual FASEB summer conference on Microbial Pathogenesis, Snowmass, CO. Mechanisms of reovirus-induced apoptosis in vitro and in vivo

2000 3rd International Symposium on Neurovirology, San Francisco, CA.Cellular mechanisms of virus-induced apoptosis: Role of the TRAIL/DR4/DR5 death receptor system

2001 Dept. of Neurology, UCSF. Frontiers in Neurology & Neuroscience (Neurology Grand Rounds). Update on herpes simplex virus infections of the CNS and Mechanisms of viral pathogenesis and cell death

(2 talks)

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2001 Western Regional Meeting American Federation for Medical Research, Western Association of Physicians, Western Society for Clinical Investigation, Carmel, CA. State of the Art Lecture. Mechanisms of virus-induced apoptosis in vitro and in vivo-lessons from the reovirus system

2001 Microbiology, Immunology, and Cancer Biology Seminar Series, University of Minnesota: Mechanisms of virus-induced cell death in vitro and in vivo.

2001 Dept. of Neurology, Dartmouth University Medical School, Neurology/Neurosurgery Grand Rounds

2001 Gordon Conference: Animal Cells and Viruses. Mechanisms of virus-induced apoptosis in vitro and in vivo: lessons from the reovirus system.

2002 Dept. of Neurology, University of Massachusetts Medical CenterNeurology Grand Rounds. Herpes simplex virus infections of the CNS in the PCR era.

2002 International Herpes Management Forum (IHMF), CNS Workshop. HSV

encephalitis in older children and adults, and Mollaret’s meningitis. Denver, CO

2002 Seminar Speaker, Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio. How a virus kills cells.

2002 5th Landau Lecturer, Washington University, St. Louis, MO. The Divine Banquet of the Brayne.

2002 Neurology-Neurosurgery Grand Rounds, Washington University, St. Louis, MO. How a virus kills cells.

2002 Panel Member, NIH/NIAID Workshop on Therapeutics for West Nile Virus Infections, Bethesda, MD

2002 Seminar Speaker, Department of Pathology & Laboratory Medicine, Texas A& M School of Medicine, College Station, TX.

2003 Seminar Speaker, Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, MA.

2003 “C. Miller Fisher Rounds” and Neuroscience Seminar, Partners Neurology Program (Brigham and MGH), Boston, MA.

2003 Invited Speaker, Annual Meeting, NIH/NIAID Collaborative Antiviral Study Group, Bethesda, MD. Challenges in the diagnosis and management of adult herpes simplex virus encephalitis.

2003 Plenary Discussant (Contemporary Clinical Issues Plenary Session), West Nile Virus, 55th Annual Meeting, American Academy of Neurology,

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Honolulu, Hawaii

2003 Plenary Speaker, 5th Meeting, International Society of Neurovirology, Baltimore, MD.

2004 Plenary Speaker and Co-Chair Session on Epidemiology/Clinical StudiesCenter for Disease Control (CDC), 5th National Conference on West Nile Virus in the United States, Denver, CO

2004 Speaker, Keystone Symposium on the Pathogen and Host Standoff: Persistent and Latent Infection. Taos, New Mexico

2004 Inaugural Walter Friedlander Lecturer, University of Nebraska School of Medicine Omaha, NE

2004 Neurology Grand Rounds, University of Chicago Pritzker School of Medicine

2004 Neurology Grand Rounds, Brigham & Women’s /Beth Israel-Deaconess Hospitals, Harvard Medical School, Boston, MA

2005 Neurology Grand Rounds, NYU School of Medicine, NY, NY

2005 Neurology Grand Rounds, Cornell University School of Medicine, NY, NY

2005 Seminar Speaker. Pathogenesis Affinity Group, The Scripps Research Institute, La Jolla, CA (How a virus kills a cell).

2005 New York Academy of Sciences. Neuroimmunology Discussion Group Meeting.

2006 Neurology Grand Rounds, Department of Neurology, Albert Einstein University School of Medicine, NY, NY.

2006 Neurology Grand Rounds, Department of Neurology, Columbia University School of Medicine, NY, NY.

2006 Neurology Grand Rounds, Department of Neurology & Neuroscience, University of California at San Diego

2007 Neurology Grand Rounds, New York University, NYC

2007 National Diabetes Trial Network (Diabetes TrialNet) Steering Committee

2007 40th Annual Winter Conference on Brain Research, Snowmass Village, CO

2007 B-Cell Summit: Targeting B Cells in the Treatment of Immune-Mediated Disease, Newport Beach, CA (Genentech/Biogen Idec)

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2007 Neurology Grand Rounds, Massachusetts General Hospital, Harvard Medical School.

2007 Speaker, Presidential Plenary Symposium, American Neurological Association 132nd Annual Meeting, Washington DC

2008 University of Illinois College of Medicine at Peoria. Seminar. Department of Cancer Biology and Pharmacology.

2008 Neurology Grand Rounds, Yale University School of Medicine

2009 Symposium, Genentech, Immunology, Tissue Growth & Repair (ITGR) Group, San Francisco, CA

2009 Neurology Grand Rounds, University of Pittsburgh School of Medicine

2009 Special Lecturer & Workshop Chair (Signal Transduction & Cellular/viral Gene Expression), 9th International Symposium on Neurovirology, Miami Beach, FL

2009 Neurology Grand Rounds, Weil Medical College, Cornell University

2009 Keynote Speaker, 27th Annual Conference on Pediatric Infectious Diseases, Vail, CO

2010 Neurology Grand Rounds, University of Kentucky College of Medicine

2010 Department of Biological Sciences Seminar, University of Denver

2010 25th Andrew Mark Lippard Lecturer, Columbia University School of Medicine

2010 Neurology Grand Rounds, NIH National Institute of Neurological Diseases & Stroke (NINDS)

2010 Plenary Speaker (Contemporary Clinical Issues Plenary Session), PML with natalizumab treatment of MS. 62nnd Annual Meeting, American Academy of Neurology, Toronto, Canada

2011 Keystone Symposium, Genetics, immunology and repair in MS (Macklin W, Giovannoni G, Hauser S, Organizers)

2011 Neurology Grand Rounds, Johns Hopkins University School of Medicine

2011 Keynote Speaker, J. Richard Baringer Graduation Symposium, Department of Neurology, University of Utah School of Medicine

2011 Speaker, Seminar Series (CNS Infections), Hope Center for Neurological Disorders, Mini-symposium on neurovirology, Washington University St. Louis.

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2011 Seminar speaker, Department of Immunology & Infectious Diseases, Montana State University

2012 Keynote Speaker, 7th Annual University of Alaska Biomedical Research Conference, Fairbanks, AK

2012 40th Robert B. Aird Visiting Professor, Neurology Department, University of California, San Francisco (UCSF)

2012 University of Maryland, Neurology Grand Rounds

2013 West Nile Virus, American Academy of Microbiology Colloquium, Denver, CO

2013 American Society for Microbiology (ASM) Conference for Undergraduate Educators, “Outbreak: West Nile virus”.

2014 Speaker & Panelist, Annual Meeting of the Association of Health Care Journalists, “What promise does the BRAIN initiative hold?” (Scott Hensley, NPR, moderator)

2014 22nd Annual Meeting, Henry Kunkel Society, Rockefeller University, invited speaker

2014 Neurohospitalist Society, 2nd Annual Meeting, Denver, COinvited speaker, “Neurovirology”

2015 67th Annual Meeting, American Academy of Neurology, Washington DC. Integrated Session Speaker (I7); Global Burden of Neurological Infections. West Nile Virus Neuroinvasive Disease.

2015 31st Clinical Virology Symposium, American Society for Microbiology (ASM), Daytona Beach, FL. Diagnostic Strategies for CNS Viral infections.

2015 Weill Cornell School of Medicine, Neurology Grand RoundsNY, NY

2016 University of Washington School of Medicine, Neurology Grand Rounds Seattle, WA

2016 University of Rochester School of Medicine, Neurology Grand RoundsRochester, NY

2016 Center for Human Immunology & Immunotherapy Programs (CHiiPs) Washington University School of Medicine, St. Louis, MO

2016 141st Annual Meeting, American Neurological Association, Keynote Speaker, President and Past President’s Dinner, Baltimore, MD

2017 Speaker, Acute Flaccid Myelitis Collaboration Meeting, Transverse

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Myelitis Association & CONQUER Program UT Southwestern, Dallas, TX

2017 Neuroscience/Neurosurgery Grand Rounds, Temple University School of Medicine

2017 Scientific Session Invited Discussant: S40 Infectious Disease: The Neurology of Zika, Chikungunya and Acute Flaccid Myelitis. American Academy of Neurology 69th Annual Meeting, Boston, MA 2017.

2017 Speaker, NIAID Enterovirus Workshop: Acute and chronic disease, preventing epidemics. Rockville, MD

2017 Speaker, CDC Acute Flaccid Myelitis Etiology Technical Consultation Atlanta, GA

2017 4th Visiting Professor, Dept. of Neurology, University of Texas Medical Branch, Galveston TX

2018 Richard Paine Lectureship, Center for Neuroscience & Behavioral Medicine, Children’s National Medical Center (invited: May, 2018)

2018 Neurology Grand Rounds, George Washington University, Washington DC (invited: May, 2018)

2018 Inaugural H. Richard Tyler lecturer, Neurology Department, Brigham and Women’s Hospital, Boston MA (invited: June, 2018)

2018 Neurology grand Rounds, Massachusetts General Hospital, Boston, MA (invited: June, 2018)

Selected Graduate and Post - graduate and CME Courses:

1983 Faculty, "Recent Advances in Neurology"(Neurovirology), Harvard Medical School-MGH Post-graduate course

1984 Co-chairman, Topics in the History of Neurology (Harvard Medical School Course 704.23)

1984 Faculty, Seminar on History of Neurology, Annual Meeting American Academy of Neurology.

1985-1988 Faculty, Course on Nervous System Pathophysiology (709.0) Harvard

Medical School

1985 Faculty, Symposium on Neurovirology, Harvard Medical School: MGH Post-graduate Course "Recent Advances in Neurology."

l985-l987 Chairman, Seminar on History of Neurology, 37th-39th Annual Meetings American Academy of Neurology.

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1985 Faculty, Course on Therapy in Neurology, 37th Annual Meeting American Academy of Neurology.

1985 Faculty, Cold Spring Harbor Laboratory Courses in Neurobiology: Molecular Neurobiology of Human Disease

1985 Co-Chairman, Symposium: Viruses and the Nervous System: Molecular Aspects and Pathogenesis, American Society for Neurological Investigation

1986-l988 Faculty, MGH Postgraduate Course, Neurology Intensive Review and Update ("Viruses and the Nervous System.")

1986 Faculty, Neurobiology of Disease Workshop: The AIDS Virus in the Nervous System, Society for Neuroscience.

1987 Workshop: Virus Infection of Immunocytes, Immunological Dysregulation and CNS Disease, Neuro-virulence and Viral Genes, (National MS Society and NINCDS)

1987-1989 Faculty, Brigham and Women's Hospital Postgraduate Course, Infectious Diseases Office and Hospital Practice ("Viral Encephalitis")

1991 Lecturer, Advanced Concepts in Vision Science, Massachusetts Eye and

Ear Infirmary, "Role of Immune System Components in Altering the Pathogenesis of CNS Viral Infections."

1991 Faculty, History of Medicine Course. Tufts University School of Medicine

1991 Faculty, Course on Infections in the Nervous System (Diagnosis of aseptic meningitis and encephalitis), 43rd Annual Meeting American Academy of Neurology, Boston, MA

1995 Faculty, Course on Therapy in Neurology (Diagnosis and management of

herpesvirus infections of the CNS, 47th Annual Meeting American Academy of Neurology, Seattle, WA

1995 Faculty, Course on CNS Infections (Recurrent meningitis), 47th Annual Meeting American Academy of Neurology, Seattle, WA

1997 Faculty, Course on Infections in the Nervous System (Viral meningitis and encephalitis), 49th Annual Meeting American Academy of Neurology, Boston, MA

1998 Faculty, Course on Infections of the Nervous System (Cranial Subdural empyema and epidural abscess), 50th Annual Meeting American Academy of Neurology, Minneapolis, MN

1998 Faculty, Course on History of Neurology (Origins of American

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Neurology), 50th Annual Meeting American Academy of Neurology, Minneapolis, MN

1999 Faculty, Course on History of Neurology (Masters of Neurology: The 19th Century: SW Mitchell & WA Hammond), 51st Annual Meeting American Academy of Neurology, Toronto, Ontario, Canada

1999 Faculty, Course on Infections of the Nervous System (Herpes simplex virus infections of the CNS), 51st Annual Meeting American Academy of Neurology, Toronto, Ontario, Canada

2000 Faculty, Course on History of Neurology (Clash of the Titans: The Goltz-Ferrier Debates on Cerebral Localization), 52nd Annual Meeting American Academy of Neurology, San Diego, CA

2000 Faculty, Course on Infections of the Nervous System (Brain abscess), 52nd Annual Meeting, American Academy of Neurology, San Diego, CA

2001 Faculty, Review and Update in Neurobiology for Neurosurgeons, Marine Biological Laboratory, Woods Hole, MA. Viral infections and the CNS.

2002 Faculty, Course on Neurovirology (Recurrent and chronic meningitis and encephalitis), 54th Annual Meeting American Academy of Neurology, Denver, CO

2002 Faculty, Course on Infections of the Nervous System (Acute encephalitis), 54th Annual Meeting American Academy of Neurology, Denver, CO

2002 Faculty, Review and Update in Neurobiology for Neurosurgeons, Marine Biological Laboratory, Woods Hole, MA. Viral infections and the CNS.

2003 Chair, Course on Neurovirology, 55th Annual Meeting American Academy of Neurology, Honolulu, Hawaii

2004 Faculty, Course on Infections in the Nervous System (Viral encephalitis)56th Annual Meeting American Academy of Neurology, San Francisco, CA

2005 Co-Director, Course on the Neurological Complications of Emerging Infections and Bioterrorism (with J. Berger), 57th Annual Meeting American Academy of Neurology, Miami Beach, FL

2006 Faculty, Course on Infections of the Nervous System (Viral encephalitis)58th Annual Meeting American Academy of Neurology, San Diego, CA.

2006 Faculty, Course on Neurological Complications of Emerging Infections and Bioterrorism, 58th Annual Meeting American Academy of Neurology, San Diego, CA.

2006 Faculty, Teaching Course on Current Treatments in Neurology (Herpes virus infection of the nervous system), 16th Meeting of the European

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Neurological Society, Lausanne Switzerland

2006 Chair, Symposium on Novel Neurotherapeutic Approaches to Neurological Diseases. American Neurological Association (ANA) 131st Annual Meeting, Chicago, IL

2006 Co-Director, Workshop on MS, JC Virus and PML. American Neurological Association (ANA) 131st Annual Meeting, Chicago, IL

2007 Faculty, Neurological Complications of Emerging Infections and Bioterrorism, 59th Annual Meeting, American Academy of Neurology, Boston, MA

2007 Chair, Derek Denny Brown Symposium, American Neurological Association (ANA) 132nd Annual Meeting, Washington, DC

2008 Faculty, Course on Infections in the Nervous System60th Annual Meeting American Academy of Neurology, Chicago, IL

2009 Faculty, 6th Hong Kong University-Pasteur Research Centre Virology Course, Hong Kong, China (July 7-24, 2009)

2009 Faculty, 27th Annual Conference on Pediatric Infectious Diseases, Vail, CO

2010 Faculty, Course on Therapy in Neurology, 62st Annual Meeting American Academy of Neurology, Toronto, Canada

2011 Faculty, Course on Infections of the Nervous System, 63st Annual Meeting American Academy of Neurology, Honolulu, Hawaii

2015 Faculty, Infectious, Paraneoplastic, Autoimmune? (C28), 67th Annual Meeting, American Academy of Neurology, Washington, DC. Diagnosis and Management of Acute Viral Encephalitis.

2015 Faculty, Neurology Update I (C37), 67th Annual Meeting, American Academy of Neurology, Washington DC. Update in Acute Viral Encephalitis.

2015 Faculty, Global Burden of Infectious Diseases (I7), 67th Annual Meeting, American Academy of Neurology, Washington DC. Arboviruses.

2017 Regis University. NS495 Current Topics in Neuroscience: Cellular Mechanisms of Neurodegeneration

2017 Faculty, Update in Neurology, 69th Annual Meeting, American Academy of Neurology, Boston, MA

2017 Update on Zika. Colorado Society of Clinical Neurologists.

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Grant Support

I. Active Primary Research Awards as PI

NIH 5R33 AI101064 Kenneth L. Tyler, P.I. Identification and evaluation of novel therapeutic targets for virus-induced neurological disease07/1/2014-5/31/2018 $299,806/annum

$900,000 total direct costs

Department of Veterans Affairs Kenneth L. Tyler, P.I.Merit Review Grant, 5I01BX000963Mechanisms of virus-induced injury in the brain and spinal cord1/1/2017-12/31/2020 $150,815/annum

$638,315 total direct costs

NIH R561NS101208 Kenneth L. Tyler, P.I.EV-D68 induced CNS disease: pathogenetic mechanisms and identification of therapeutic targets04/01/2017-3/31/2018 $218,750/annumR01 4/1/2017-3/31/2022R56 Award for Yr.1 (4/01/2017-3/30/2018 pending R01 funding line decisions

NIH R21 NS103186 Kenneth L. Tyler, P.I. Identification and evaluation of therapeutic strategies for Zika-virus induced CNS disease7/1/2017-6/30/2019 $137,500/annum

$275,000 total direct costs

II. Active Primary research Awards as Co-Investigator

National MS Society, Collaborative Research Center Award Wendy Macklin, Ph.D (PI)Mechanisms of glial injury in demyelinating disorders Kenneth L. Tyler. M.D. (Co-I)04/1/2013-3/31/2018 $150,000/annum

$750,000 total direct costs

III. Active Awards as MentorNIH K23 AI28069 Kevin Messacar, M.D.

(recipient) (Co-Mentor of this K23 with S. Dominguez, M.D.)Implementation and effectiveness of a rapid CSF diagnostics program for children with

suspectedCNS Infection9/1/2016-8/31/2021 $197,178 per annum

$986,757 total direct costs

NIH F31 NS100565 Stephanie Bonney (recipient)Vascular instability in encephalitis $30,000/annum(Co-mentor of this F31 with J. Siegenthaler, Ph.D.) $90,000 total direct costs2017-2020

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IV. Training Grants

NIH 5-T32-AI052066 (Predoctoral TG) Andres Vazquez-Torres, PIMolecular Pathogenesis of Infectious Disease $128,414 per annum8/1/13-7/31/2018 ~$$642,070 totalRole: Associate Director

NIH 9T32-NS099042 (Predoctoral TG) Vijaraghavan, S. (PI)Neuroscience Training Grant $197,292 per annum7/1/2016-6/30/2021 ~$$986,460 totalRole: Exec. Cmte, Faculty

V. Selected Completed Awards as PINIH 1R01 NS076512 Kenneth L. Tyler, P.I.Cellular genes and signaling pathways as therapeutic targets for viral CNS disease9/15/2011-5/31/2016 $22,750 /annum

$900,000 total direct costs

NIH 1 R21 AI101064 Kenneth L. Tyler, P.I. Identification and evaluation of novel therapeutic targets for Zika virus-induced neurological disease07/1/2012-6/30/2014 $127,040/annum

$250,000 total direct costs

NIH 1 R01 NS051403 Kenneth L. Tyler, P.I.Mechanisms of virus-induced apoptosis in neurons and CNS02/07/2006-12/31/2011

$202,500/annum$1,012,500 total direct costs

NIH/NINDS 1R01 NS050138 Kenneth L. Tyler, P.I.Mechanisms of apoptosis in the central nervous system1/1/2005-12/31/2010

$208,125/annum$1,040,625 total direct costs

Department of Veterans Affairs Kenneth L. Tyler, P.I.Merit Review GrantMechanisms and treatment of viral myelitis and spinal motor neuron injury10/1/06-9/31/10

$124,900/annum$499,600 total direct costs

DAMD17-98-1-8614 Kenneth L. Tyler, P.I.US Army Medical Research & Material Command 20% Effort(Neurotoxin Exposure Research treatment Program) $236,143/annumMechanisms of virus-induced neural cell death $1,534,932 total direct costs7/1/98-3/14/05

26

Department of Veterans Affairs Kenneth L. Tyler, P.I.Merit Review Grant 15% EffortMechanisms of virus-induced apoptosis $119,400/annum5/1/01-4/31/06 $627, 100 total direct costs

Department of Veterans Affairs Kenneth L. Tyler, P.I.Research Enhancement Award Program (REAP) 5% EffortMechanisms & prevention of cell death in neurodegenerative diseases4/1/99-3/31/05 $250,000/annum

$1,350,000 total direct costs

VI. Selected Completed Awards as Mentor NIH 2T32 NS007321 Donald H. Gilden, P.I.Neurovirology-Molecular Biology training grantNIH/NINCDS7/1/10 - 9/14/16 Role: Executive Committee, Faculty

NIH NINDS 1F30NS071630 Sponsor/Mentor: Kenneth L. TylerIndividual Predoctoral Fellowship Award Recipient/trainee: Kalen DionneRole of Daxx in reovirus-induced apoptosis09/01/2010-8/30/2014 ~$30,000/annum

~$90,000 total direct costs

NIH K08 1K08AI076518 Sponsor/Mentor: Kenneth L. TylerMentored Clinician-Scientist Award Recipient/Trainee: Dr. David BeckhamMechanisms of Apoptosis in virus-infected neurons and brain10/1/08-9/30/13 ~$125,000/annum

~$625,000 total direct costs

NIH NINDS 1F31NS062583 Sponsor/Mentor: Kenneth L. TylerIndividual Predoctoral Fellowship Award Recipient/Trainee: Stephanie SchittoneMechanisms of virus-induced motor neuron injury and treatment of viral myelitis3/1/2008-2/28/2011 ~$30,000/annum

~$90,000 total direct costs

Department of Veterans AffairsResearch Career Development Award Recipient: Roberta DeBiasi, M.D

Sponsor/Mentor: Kenneth L. Tyler, Role of apoptotic signaling pathways in virus-induced cell death and their role as targets for antiviral therapy. 12/1/02-11/31/05

NIH/NIAID1 K08 AI52261 Recipient: Roberta DeBiasi, M.D.

Mentor: Kenneth L. TylerApoptotic signaling in viral myocarditis

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9/1/2002-5/31/2007

Department of Veterans Affairs Recipient/Trainee: David Beckham, M.D.,Research Career Development Award (RCDA) Sponsor/Mentor: Kenneth L. TylerMechanisms of apoptosis in virus-infected neurons and brain10/1/2007-9/30/2008

28

Bibliography:

I. Peer-reviewed Journals:

1. Tyler KL, Poletti CE, Heros RC. Cerebral amyloid angiopathy with multiple intracerebral hemorrhages. J Neurosurg 57:286-289, 1982.

2. Tyler KL, Alder D. Twenty-eight years of benign recurring Mollaret's meningitis. Arch Neurol 40:42-43, 1983.

3. Tyler KL. Diagnosis and management of acute viral encephalitis. Semin Neurol 4:480-489, 1984.

4. Tyler KL, Tyler HR. Answers to questions on stroke. Hospital Medicine. 19:206-228, July 1983 (Part I); 19:89-104, August 1983 (Part II).

5. Tyler KL, Tyler HR. Differentiating organic dementia. Geriatrics. 39:38-52, 1984.

6. Tyler KL, Bronson RT, Byers KB, Fields BN. The molecular basis of viral neurotropism: experimental reovirus infection. Neurology 35:88-92, 1985.

7. Tyler KL, Gross RA, Cascino GD. Unusual viral causes of transverse myelitis: hepatitis

A virus and cytomegalovirus. Neurology 36:855-858, 1986.

8. Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol 59:90-97, 1986. [PMC253042]

9. Tyler KL, McPhee DA, Fields BN. Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science 233:770-774, 1986.

10. Bassel-Duby R, Spriggs DR, Tyler KL, Fields BN. Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with use of a rapid sequencing technique. J Virol 60:64-67, 1986. [PMC253902]

11. Gonzalez-Scarano F, Tyler KL. Molecular pathogenesis of neurotropic viral infections. Ann Neurol 22:565-574, 1987.

12. Tyler KL. Host and viral factors which influence viral neurotropism. I. Cell receptors and viral cell attachment proteins. Trends Neurosci 10:455-460, 1987.

13. Tyler KL. Host and viral factors which influence viral neurotropism. II. Viral genes, host genes, site of entry and route of spread of virus. Trends Neurosci 10:492-497, 1987.

14. Tyler KL, McPhee DA. Molecular and genetic aspects of the pathogenesis of viral infections of the central nervous system. Crit Rev Neurobiol 3:221-243, 1987.

15. Tyler KL, Davis KR, Hedley-Whyte T. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 45-1988. A 67-year old woman with chronic lymphocytic leukemia, homonymous hemianopia, confusion, and poor balance (Progressive Multifocal Leucoencephalopathy). N Engl J Med 319:1268-1280,

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1988.

16. Virgin HW IVth, Bassel-Duby R, Fields BN, Tyler KL. Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing). J Virol 62:4594-4604, 1988. [PMC253571]

17. Lipkin I, Tyler KL, Waksman BH. Viruses, the immune system and central nervous system diseases. Trends Neurosci 11:43-45, 1988.

18. Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol 63:759-768, 1989. [PMC247748]

19. Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia, but do not reactivate. Proc Natl Acad Sci U.S.A 86:4736-4740, 1989. [PMC287348]

20. Tyler KL, Virgin HW IVth, Bassel-Duby R, Fields BN. Antibody inhibits defined stages in the pathogenesis of reovirus serotype 3 infection of the central nervous system. J Exp Med 170:887-900, 1989.

21. Sacks SL, Wanklin RJ, Reece DE, Hicks KA, Tyler KL, Coen DM. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann Intern Med 111:893-899, 1989.

22. Tyler KL. Pathogenesis of Reovirus infections of the central nervous system. Semin Neurosci 3:117-124, 1991.

23. Virgin HW IVth, Tyler KL. The role of immune cells in protection against and control of reovirus infection in neonatal mice. J Virol 65:5157-5164, 1991. [PMC248992]

24. Virgin HW IVth, Mann MA, Fields BN, Tyler KL. Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action. J Virol 65:6772- 6781, 1991. [PMC250764]

25. Ravilochan K, Tyler KL. Human transmissible neurodegenerative diseases(prion diseases). Semin Neurol 12:178-192, 1992.

26. Tyler KL, Mann MA, Fields BN, Virgin HW IVth. Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis. J Virol 67:3446-3453, 1993. [PMC237690]

27. Sherry B, Li X-L, Tyler KL, Cullen JM, Virgin HW IVth. Lymphocytes protect against,

and are not required for, reovirus-induced myocarditis. J Virol 67: 6119-6124, 1993. [PMC238034]

28. Watson CPN, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E.A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15:510-526,1993.

30

29. Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes Simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med 121:334-338,1994.

30. Virgin HW IVth, Mann MA, Tyler KL. Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases. J. Virol 68:6719-6729, 1994. [PMC237093]

31. Tyler KL, Sandberg E, Baum KF. Medial medullary syndrome and meningovascular syphilis: A case report in an HIV-infected man, and review of the literature. Neurology 44: 2231-2235,1994.

32. Tyler KL. Polymerase chain reaction and the diagnosis of viral CNS diseases. Ann Neurol 36: 809-811, 1994.

33. Paskavitz JF, Anderson CA, Filley CM, Kleinschmidt-Demasters BK, Tyler KL. Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann Neurol 38: 127-131, 1995.

34. Dermody TS, Chappell JD, Hofler JG, Kramp W, Tyler KL. Eradication of persistent reovirus infection from a B-cell hybridoma. Virology 212:272-276, 1995.

35. Tyler KL, Squier MKT, Rodgers SE, Schneider BE, Oberhaus SM, Grdina TA, Cohen JJ, Dermody TS. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein 1. J Virol 69:6972-6979, 1995. [PMC189616]

36. Tyler KL, Tedder DG, Yamamoto LJ, Klapper JA, Ashley R, Lichtenstein KA, Levin MJ. Recurrent brainstem encephalitis associated with herpes simplex virus type 1 DNA in cerebrospinal fluid. Neurology 45: 2246-2250, 1995.

37. Almond JW, Brown P, Gore SM, Hofman A, Wientjens PW, Ridley RM, Baker HF, Roberts GW, Tyler KL. Creutzfeldt-Jakob disease and bovine spongiform encephalopathy: any connection? BMJ (British Medical Journal) 311:1415-1421, 1995.

{Tyler KL. Risk of human exposure to bovine spongiform encephalopathy. BMJ (British Medical Journal) 311: 1420-1421, 1995.]

38. Tyler KL, Squier MKT, Brown AL, Pike B, Willis D, Oberhaus SM, Dermody TS, Cohen JJ. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol 70:7984-7991, 1996. [PMC190871]

39. Rodgers SE, Barton ES, Oberhaus SM, Pike B, Gibson CA, Tyler KL, Dermody TS. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by bcl-2. J Virol 71: 2540-2546,1997. [PMC191370]

40. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol71:2100-2106,1997. [PMC191302]

41. Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus. Curr Top Microbiol.Immunol 233/2:23-49, 1998.

31

42. Tyler KL. Pathogenesis of reovirus infections of the central nervous system. Curr Top Microbiol Immunol 233/2:93-124, 1998.

43. Virgin HW IVth, Dermody TS, Tyler KL. Cellular and humoral immunity to reovirus infection. Curr Top Microbiol Immunol 233/2:147-161, 1998.

44. Tyler KL, Sokol RJ, Oberhaus SM, Mysan L, Murphy JR, Low R, Brown WR. Detection of reovirus RNA in hepatobiliary tissues from patients with extrahepatic bile duct atresia and choledochal cysts. Hepatology 27:1475-1482, 1998.

45. Fodor PA, Levin MJ, Weinberg A, Sandberg E, Sylman J, Tyler KL. Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF. Neurology 51:554-559,1998.

46. Kleinschmidt-DeMasters BK, Mahalingham R, Shimek C, Tyler KL, Gilden DH. Profound CSF pleocytosis and Froin’s syndrome secondary to widespread necrotizing vasculitis in varicella-zoster encephalomyelitis. J Neurol Sci 159:213-218, 1998.

47. Pelosi E, Rozenberg F, Coen DM, Tyler KL. A Herpes Simplex virus DNA polymerase mutant that specifically attenuates neurovirulence in mice.Virology 252:364-372, 1998.

48. DeBiasi RL, Squier MKT, Pike B, Wynes M, Dermody TS, Cohen JJ, Tyler KL. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J. Virol. 73:695-701, 1999. [PMC103876]

49. Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology 52:623-625,1999.

50. DeBiasi RL, Tyler KL. Polymerase chain reaction in the diagnosis and management of nervous system infections. Arch Neurol 56:1215-1219, 1999.

51. Anderson CA, Sandberg E, Filley CM, Harris SL, Tyler KL. One and one-half syndrome with supranuclear facial weakness. Magnetic resonance imaging localization. Arch Neurol 56:1509-1511,1999.

52. Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-B J Virol 74:2981-2989, 2000. [PMC111796]

53. Yijuri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler KL, Oka Y, Fanger GR, Henson P, Johnson GL.MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-B activation. Proc Natl Acad Sci U.S.A 97:7272-7277, 2000. [PMC16535]

54. Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL. J Virol 74: 8135-8139, 2000. [PMC112347]

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55. Poggioli GJ, Keefer C, Connolly JL, Dermody TS, Tyler KL. Reovirus-induced G2/M arrest requires s and occurs in the absence of apoptosis. J Virol 74:9562-9570, 2000. [PMC112387]

56. DeBiasi R, Edelstein C, Sherry B, Tyler KL. Calpain inhibition protects against virus-induced apoptotic myocardial injury J Virol 75:351-361, 2001. [PMC113928]

57. Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli G. Reovirus and the host cell.. Trends Microbiol 9:560-564, 2001.

58. Poggioli GJ, Dermody TS, Tyler KL. Reovirus-induced 1s-dependent G2/M cell cycle arrest is associated with inhibition of p34cdc2. J Virol 75:7429-7434, 2001. [PMC114978]

59. DeMasters BK, DeBiasi R, Tyler KL. Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system. Brain Pathol.11:452-464, 2001.

60. Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK-dependent transcription factor c-Jun. J Virol 75:11275-11283, 2001. [PMC114712]

61. Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase-8 dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus infection. Oncogene 20:6910-6919, 2001.

62. Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NFB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene 21:260-271, 2002.

63. Poggioli GJ, DeBiasi RL, Bickel, R., Bickel R, Jotte R, Spalding A, Johnson GL, Tyler KL. Reovirus-induced alterations in gene expression related to cell cycle regulation. J Virol 76:2585-2594, 2002. [PMC135961]

64. Redington JJ, Tyler KL. Viral infections of the nervous system 2002. Update on diagnosis and treatment. Arch Neurol 59:712-718, 2002.

65. DeBiasi RL, Kleinschmidt-DeMasters BK, Weinberg A, Tyler KL. Use of PCR for the diagnosis of herpesvirus infections of the central nervous system. J Clin Virol 25 (suppl):5-11, 2002.

66. Kominsky D, Bickel RJ, Tyler KL. Reovirus induced apoptosis requires both death-receptor- and mitochondrial-mediated caspase-dependent pathways of cell death. Cell Death and Differentiation 9:926-933, 2002.

67. Richardson-Burns S, Tyler KL. Reovirus induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol 8:365-380, 2002.

68. Weinberg A, Li S, Palmer M, Tyler KL. Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous system. Ann Neurol 52:543-548, 2002.

69. Kominsky DJ, Bickel R, Tyler KL. Reovirus-induced apoptosis requires mitochondrial

33

release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levels. J Virol 76:11414-11424, 2002. [PMC136770]

70. DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Herpes simplex virus and cytomegalovirus encephalitis in humans are associated with CNS apoptosis. J Infect Dis 186:1547-1557, 2002.

71. Richardson-Burns S, DeBiasi R, Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy is associated with apoptosis of infected oligodendrocytes in the CNS of AIDS and non-AIDS patients. Arch Neurol 59:1930-1936, 2002.

72. Mann MA, Tyler KL, Knipe DM, Fields BN. Type 3 reovirus neuroinvasion after

intramuscular inoculation: Viral genetic determinants of lethality and spinal cord infection. Virology 303:213-221, 2002.

73. Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview. Apoptosis 8:141-150, 2003.

74. Clarke P, Meintzer S, Moffitt L, Tyler KL. Two distinct phases of virus-induced NF-B regulation enhance TRAIL-mediated apoptosis in virus-infected cells. J Biol Chem 278:18092-18100, 2003.

75. Gonzales N, Tyler KL, Gilden DH. Recurrent dermatomal vesicular skin lesions. A clue to diagnosis of herpes simplex virus 2 meningitis. Arch. Neurol. 60:868-869, 2003.

76. DeBiasi RL, Clarke P, Meintzer S, Jotte R, Kleinschmidt-DeMasters BK, Johnson GL, Tyler KL. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. J Virol 77: 8934-8947, 2003. [PMC167209]

77. Cuevas BD, Abell AN, Witowsky JA, Yujiri T, Johnson NL, Kesavan K, Ware M, Jones PL, Weed SA, DeBiasi RL, Oka Y, Tyler KL, Johnson GL. MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. EMBO J 22:3346-3355, 2003. [PMC165646]

78. McCabe K, Tyler KL, Tanabe J. Diffusion-weighted MRI abnormalities: a clue to the diagnosis of herpes simplex encephalitis. Neurology 61:1015-1016, 2003.

79. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MBA. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322:231-8, 2004.

80. Richardson-Burns SM, Tyler KL. Regional differences in viral growth and CNS injury correlate with apoptosis. J Virology 78:5466-75, 2004. [PMC400348]

81. Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O’Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS. Isolation and characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis 189:1664-75, 2004.

82. Hoyt C, Bouchard R, Tyler KL. Novel nuclear herniations induced by nuclear localization of a viral protein. J Virology 78:6360-6369, 2004. [PMC416550]

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83. Tyler KL, West Nile virus in the United States. Arch Neurol 61:1190-1195, 2004.

84. Kleinschmidt-DeMasters BK, Marder B, Levi M, Laird SP, McNutt T. Escott E, Everson GT, Tyler KL. Naturally-acquired West Nile virus encephalomyelitis in transplant recipients: Clinical, laboratory, diagnostic and neuropathological features. Arch Neurol 61:1210-1220, 2004.

85. Tyler, KL. Herpes simplex virus infections of the central nervous system: Encephalitis and meningitis, including Mollaret’s. Herpes 11 (suppl 2):57A-64A, 2004.

86. DeBiasi RL, Tyler KL. Molecular methods for diagnosis of viral encephalitis. Clinical Microbiol Rev. 17:903-925, 2004. [PMC523566]

87. DeBiasi RL, Robinson BA, Sherry B, Bouchard R, Brown RD, Rizeq M, Long C, Tyler KL. Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo. J. Virol. 78:11040-11050, 2004. [PMC521817]

88. Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of pro-apoptotic mitochondrial factors in reovirus-infected cells. J. Virology 78:13132-13138, 2004. [PMC524973]

89. Tyler KL. Infectious Diseases: West Nile virus. Rev. Neurol. Dis. 1:49-51, 2004.

90. Tyler KL. West Nile virus infection. Rev. Neurol. Dis. 1:83-90, 2004.

91. Tyler KL. Update on herpes simplex encephalitis. Rev. Neurol. Dis. 1:169-178, 2004.

92. Weinberg A, Bloch KC, Li S, Tang Y-W, Palmer M, Tyler KL. Dual infections of the central nervous system with Epstein-Barr virus. J. Infect. Dis. 191:234-237, 2005.

93. Hoyt C, Richardson-Burns S, Goody R, Tyler KL. Reovirus non-structural protein 1s is a determinant of virulence in the heart and CNS. J. Virol. 79:2743-2753, 2005. [PMC548430]

94. Beckham JD, Tyler KL. Progressive multifocal leukoencephalopathy following natalizumab therapy. Rev.Neurol. Dis. 2:158-163, 2005.

95. Tyler KL, Khalili K. Natalizumab and progressive multifocal leukoencephalopathy.. Rev. Neurol. Dis. 2:144-149, 2005.

96. Richardson-Burns, SM, Tyler KL. Minocycline delays disease onset and mortality in a murine model of viral encephalitis. Exp. Neurol. 192:331-339, 2005. [PMC2362387]

97. Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Curr. Topics Microbiol. Immunol. 289: 1-24, 2005. [PMC2367090]

98. Clarke P, DeBiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: Role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 18:89-116, 2005. [PMC2366905]

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99. Clarke P, DeBiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis 10:513-524, 2005.

100. Le SS, Loucks A, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA. Inhibition of Rac GTPase triggers a c-Jun and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J. Neurochem. 94:1025-39, 2005. [PMC2366110]

101. DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon--1a for multiple sclerosis. N. Engl. J. Med. 353:369-374, 2005.

102. Goody RJ, Hoyt CC, Tyler KL. Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp. Neurol. 195:379-90, 2005. [PMC2367058]

103. Lapadat R, DeBiasi RL, Johnson GL, Tyler KL. Genes induced by reovirus infection have a distinct modular cis-regulatory arrangement. Current Genomics 6:501-514, 2005.

104. Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis. Neurology 66:361-365, 2006.

105. Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nature Clin. Pract. Neurol. 2: 264-275, 2006.

106. Beckham JD, Tyler KL. Initial management of acute bacterial meningitis in adults: Summary of IDSA guidelines. Rev. Neurol. Dis. 3:57-60, 2006.

107. Davis LE, DeBiasi RL, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters, B.K., Tyler KL. West Nile virus neuroinvasive disease. Annals Neurol. 60:286-300, 2006.

108. Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis 12:211-223, 2007. [PMC2365758]

109. Gilden DH, Mahalingam R, Cohrs RJ, Tyler KL. Herpesvirus infections of the nervous system. Nature Clin. Pract. Neurology 3:82-94, 2007.

110. Tyler KL, Aksamit AJ, Keegan BM, Parisi JE. An 85-year-old man with chronic lymphocytic leukemia and altered mental status. Neurology 68:460-7, 2007.

111. Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-DeMasters BK, Pape JW, Tyler KL. Colorado surveillance program for chronic wasting disease transmission to humans: lessons from two highly suspicious but negative cases. Arch. Neurol. 64:439-441, 2007.

112. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for the treatment

36

of viral central nervous system infection by using a cell-permeable inhibitor of c-Jun N-terminal kinase. J. Virol. 81:6984-6992, 2007. [PMC1933289]

113. Goody R, Rutsova K, Beckham, D, Tyler KL. J. Neurovirol. JAK-STAT signaling pathways are activated in the brain following reovirus infection. J. Neurovirol. 13:373-383, 2007. [PMC2367059]

114. Zimmerman AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA. Glutathione binding to the BCL-2 homology-3 domain groove: A molecular basis for BCL-2 antioxidant function at mitochondria. J. Biol. Chem. 282:29296-29304, 2007 [PMC 2386251]

115. Beckham JD, Tyler KL. Infectious disease-Developments in the field of Creutzfeldt-Jakob disease. Rev. Neurol Dis. 4: 168-172, 2007. [PMC2613287]

116. Hudson LA, Rollins YD, Anderson CA, Johnston-Brooks C, Tyler KL, Filley CM. Reduplicative paramnesia in Morvan’s syndrome. J. Neurol. Sci.267:154-157, 2008.

117. Tyler KL, Beckham JD. Management of acute shingles (herpes zoster). Rev. Neurol. Dis. 4: 203-208, 2007.

118. Hall DA, Tyler KL, Frey KL, Kozora E, Arciniegas DB. Persistent neurobehavioral signs and symptoms following West Nile Fever. J. Neuropsychiatry & Clin. Neurosci. 20:122-123, 2008.

119. Goody RJ, Schittone SA, Tyler KL. Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell death. J. Neuropathol. Exp. Neurol. 67:231-239, 2008. [PMC2365907]

120. Tyler KL. Acute pyogenic discitis (spondylodiscitis) in adults. Rev. Neurol. Dis. 5:8-13, 2008.

121. Davis LE, Beckham JD, Tyler KL. North American encephalitic arboviruses. Neurol. Clin. 26 :727-757, 2008. [PMC2866042]

122. Tyler KL. Genes determining susceptibility to human herpes simplex virus encephalitis. Rev. Neurol. Dis. 5: 206-8, 2008.

123. Tyler KL. Neurological infections: Advances in therapy, outcome and prediction. Lancet Neurol. 8:19-21, 2009.

124. Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nature Rev. Microbiol. 7:144-55, 2009. [PMC2772826]

125. Tyler KL. Prednisolone-but not antiviral drugs-improves outcome in patients with Bell’s palsy. Nature Clin Prac Neurology 5:74-5, 2009.

126. Beckham JD, Tuttle K, Tyler KL. Reovirus activates TGF-β and BMP signaling pathwaysin the CNS which contribute to neuronal survival following infection . J. Virol. 83:5035-45, 2009. [PMC2687381]

37

127. Boster A, Hreha S, Berger JR, Bao F, Penmesta R, Tselis A, Endress C, Zak I, Perumal J, Caon C, Vazquez J, Tyler KL, Racke MK, Mills S, Khan O. Progressive multifocal leukoencephalopathy and relapsing-remitting multiple sclerosis: a comparative study. Arch. Neurol. 66:593-599, 2009.

128. Clarke P, Hoyt C, Beckham JD, Tyler KL. Fas-mediated apoptotic signaling in the mousebrain following reovirus infection. J. Virol. 83:6165-6170, 2009. [PMC2687381]

129. Miyamoto SD, Brown RD, Robinson BA, Tyler KL, Long CS, DeBiasi RL. Cardiac cell-specific apoptotic and cytokine responses to reovirus Infection: Determinants of myocarditic phenotype. J Card Fail 15:529-39, 2009. [PMC2772824].

130. Levi ME, Quan D, Ho JT, Kleinschmidt-DeMasters BK, Tyler KL, Grazia TJ. Impact of rituximab-associated B cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients. Clin Transplantation 24:223-8, 2009. [PMC2873850]

131. Korman BD, Tyler KL, Korman NJ. Progressive multifocal leukoencephalopathy, efalizumab, and immunosuppression: a cautionary tale for dermatologists. Arch. Derm. 145:937-42, 2009.

132. Tyler KL. Emerging viral infections of the central nervous system: Part 1. Arch. Neurol. 66:939-48, 2009. [PMC2873855]

133. Tyler KL. Emerging viral infections of the central nervous system. Part II. Arch. Neurol. 66:1065-74, 2009. [PMC2876734]

134. Blakely P, Kleinschmidt-DeMasters BK, Tyler KL, Irani D. Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. J. Neuropathol. Exp. Neurol. 68:1061-72, 2009. [PMC2854566]

135. Tyler KL, Leser JS, Phang TL, Clarke P. Gene expression in the brain during reovirus encephalitis. J. Neurovirol. 16:56-71, 2010. [PMC2891017]

136. Beckham JD, Tuttle K, Tyler KL. Caspase 3 activation is required for reovirus-induced encephalitis in vivo. J Neurovirol. 16:306-17, 2010. [PMC3023174]

137. Dionne KR, Leser JS, Lorenzen KA, Beckham JD, Tyler KL. A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition. Exp. Neurol 228:222-31, 2011. [PMC3060973]

138. Berens HM, Tyler KL. The pro-apoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. J. Virol. 85:3858-71, 2011. [PMC3126143]

139. Dionne KR, Galvin JM, Schittone SA, Clarke P, Tyler KL. Type I interferon signalinglimits reoviral tropism within the brain and prevents lethal systemic infection. J. Neurovirol. 17:314-26, 2011.[PMC3060973]

140. Clifford DB, Ances B, Costello C, Rosen-Schmidt S, Andersson M, Parks D, Perry A, Yerra R, Schmidt R, Alvarez E, Tyler KL. Rituximab associated progressive multifocal leukoencephalopathy in rheumatoid arthritis. Arch. Neurol. 68:1156-1164, 2011. [PMC3428054]

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141. Wilson MR, Tyler KL. Issues and updates in emerging neurologic viral infections. Semin. Neurol. 31:245-53, 2011. [PMID2964843].

142. Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics, 9:124-38, 2012. [PMC3271160].

143. Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by the inhibition of Rac GTPase activity J. Biol. Chem. 287:16835-48, 2012. [PMC3351344]

144. Schittone S, Dionne K, Tyler KL, Clarke P. Activation of innate immune responses in the CNS during reovirus myelitis. J.Virol. 86:8107-18, 2012. [PMC3421655]

145. Beatman, E., Oyer R, Shives KD, Hedman K, Brault AC, Tyler KL, Beckham JD. West Nile virus growth is independent of autophagy activation. Virology 433:262-72, 2012 [PMC3444629]

146. Dionne K, Zhuang Y, Tyler KL, Clarke P. Daxx upregulation in the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J. Virol. 87:3447-3460, 2013 [PMC3592169].

147. Tyler KL, Johnson EC, Cantu DS, Haller BL. A 20-year-old woman with headache and transient numbness. The Neurohospitalist 3:101-110, 2013. [PMC3726119]

148. Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 70: 1060-1064, 2013. [PMID23732875].

149. Nath A, and Tyler KL. Novel approaches and challenges to treatment of CNS viral infections. Ann. Neurol. 74:412-22, 2013. [PMID23913580].

150. Dionne KR, Tyler KL. Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol. Biol. 1078:97-117, 2013. [PMID23975824].

151. Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor mediated apoptotic signaling is activated in the brain following infection with West Nile Virus in the absence of a peripheral immune response. J. Virol 88:1080-9, 2014. [PMC3911655].

152. Tyler KL. Current developments in understanding of West Nile virus central nervous system disease. Curr. Opin. Neurol 27:342-8, 2014. [PMID 24722324]

153. Clarke P, Leser JS ,Bowen RA , Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, IL17RA and glutamate signaling as well as the flavivirus-specific up-regulation of tRNA synthetases. MBio 5(2):e00902-14. doi. 10.1128/mBio.00902-14. [PMC3952157].

154. Quick, ED., Leser JS., Clarke P, Tyler K. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice model of West Nile virus

39

infection. J. Virol. 88:13005-13014, 2014. [PMC4249089].

155. Tyler KL. Rationale for the evaluation of fluoxetine in the treatment of enterovirus-D68-associated acute flaccid myelitis [viewpoint] JAMA Neurol 72:493-4, 2015. [PMC5086417]

156. Patera AC, Butler SL, Cinque P, Clifford DB, Elston R, Garcia RL, Major EO, Pavlovic D, Peterson IS, Ryan AM, Tyler KL, Weber T. 2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment. J. Neurovirol. 21: 702-705, 2015. [PMID:26501778].

157. Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Neuroinfectious Diseases) 21:1599-1611, 2015. [PMID 26633778].

158. Pastula DM, Smith DE, Beckham JD, Tyler KL. An overview of Zika virus disease. Neurohospitalist 6:93-4, 2016.[PMC:4906558]

159. Pastula DM, Beckham JD, Smith DE, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, Chikungunya and Zika virus diseases. J Neurovirol 22:257-260, 2016. [PMC5087598].

160. Beckham JD, Pastula DM, Massey A, Tyler KL. Zika virus as an emerging global pathogen. Neurological complications of Zika virus. JAMA Neurology 73:875-879. 2016. [PMC5087605]

161. Zhuang Y, Berens-Norman H, Leser JS, Clarke P, Tyler KL. Mitochondrial p53 contributes to reovirus-induced neuronal apoptosis and CNS injury in a mouse model of viral encephalitis. J Virol 90:7684-91, 2016. [PMC4988164]

162. Vasek MJ, Garber C, Dorsey D, Durrant D, Bollman B, Yu J, Perez-Torres C, Frouin A, Wilton DK, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. A complement-microglial axis is required for synapse elimination during virus-induced memory impairment. Nature 534:538-543, 2016. [PMID 27337340].

163. White MK, Wollebo HS, Beckham JD, Tyler KL, Khalili K. Zika virus: an emergent neuropathologic agent. Annals Neurology 80:479-89, 2016 [PMC5086418]

164. Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler K, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Annals Neurology 80:326-338, 2016. [PMID 27422805]

165. Wilson M, Tyler KL. Emerging diagnostic and therapeutic tools for central nervous system infections. JAMA Neurology 73: 1389-90, 2016. [PMID: 2769862].

166: Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Practice 6:515-522, 2016. [PMID: 28058206]

167. Pastula DM, Durant JC, Smith DE, Beckham JD, Tyler KL. Zika virus disease for the

40

neurointensivitst. Neurocrit Care26:457-463, 2017. [PMID 27995511].

168: Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika virus disease and associated neurologic complications. Curr Infect Dis Rep Curr Infect Dis Rep. 2017 Jan;19(1):4. doi: 10.1007/s11908-017-0557-x. [PMID:28220392]

169. Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, Tyler KL. A mouse model ofparalytic myelitis caused by enterovirus D68. PLoS Pathogens PLoS Pathog. 2017 Feb 23;13(2):e1006199. doi: 10.1371/journal.ppat.1006199. [PMC: 5322875]

170. Shives KD, Tyler KL, Beckham JD. Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. J. Neuroimmunol.308:102-111, 2017. [PMID: 28291542]

171. Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado Children with acute flaccid myelitis at one year. Neurology 89:129-137, 2017. PMID:28615421

172. Quick EA, Seitz S, Clarke P, Tyler KL. Minocycline has anti-inflammatory effects and reduces cytotoxicity in an ex vivo spinal cord slice culture model of West Nile virus infection. J. Virol. doi: 10.1128/JVI.00569-17. [Epub ahead of print]. PMID:28878079

173. Hixson AM, Clarke P, Tyler KL. Evaluating treatment efficacy in a mouse model of Enterovirus D-68 paralytic myelitis. J. Infect. Dis doi.org/10.1093/infdis/jix46 [Epub ahead of print] PMID:28968718.

174: McGuinness I, Beckham JD, Tyler KL, Pastula DM. An overview of Yellow Fever virus disease. Neurohospitalist 7:157-8, 2017. PMID:28974992

175. Hoon-hanks LL, McGrath S, Tyler KL, Owen C, Steinglein MD. Metagenomic investigation of idiopathic meningoencephalomyelitis in dogs. Journal of Veterinary Internal Medicine doi: 10.1111/jvim.14877. [Epub ahead of print] PMID: 29197179

176. Messacar K, Fischer M, Domingues SR, Tyler KL, Abzug MD. Encephalitis in U.S. Children. Infectious Disease Clinics North Amer. doi: 10.1016/j.idc.2017.10.007. [Epub ahead of print, 2017]. PMID 29224854

41

II. History of Neurology (Original Articles and Book Chapters)

1. Tyler KL, McHenry LC Jr. Classics in Neurology: Pseudohypertrophic muscular dystrophy and Gower's sign. Neurology. 33:88-89, 1983.

2. Tyler KL. Classics in Neurology: "Tetanoid Chorea" and progressive lenticular degeneration. Neurology. 33:461-462, 1983.

3. Tyler KL, McHenry LC Jr. Classics in Neurology: The knee jerk and other tendon reflexes. Neurology. 33:609-610, 1983.

4. Tyler KL. Hughlings Jackson: The early development of his ideas on epilepsy. J. Hist. Med Allied Sci. 39:55-64, 1984.

5. Tyler HR, Tyler KL. Charles Edouard Brown-Sequard: professor of physiology and pathology of the nervous system at Harvard Medical School. Neurology. 34:1231-1236, 1984.

6. Tyler HR, Tyler KL. Classics in Neurology: “Organic remains of a former world”. Neurology 35:371, 1985.

7. Tyler HR, Tyler KL. Classics in Neurology: Drawings of Leonardo da Vinci. Neurology 35:636, 1985.

8. Tyler HR, Tyler KL. Classics in Neurology: Communication between lateral and third ventricle: First description. Neurology 35: 1298, 1985.

9. Tyler KL, Tyler HR. The secret life of James Parkinson (1755-1824): The writings of Old Hubert. Neurology. 36:222-224, 1986.

10. Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.). Handbook of Parkinson's Disease. M Dekker Inc., NY, 1987:1-33.

11. Tyler KL, Vignette: William G. Spiller (1863-1940). Annals Neurol. 31: 686, 1992.

12. Tyler KL. A History of Parkinson's Disease. In: Koller WC (Ed.).Handbook of Parkinson's Disease (2nd ed.) M. Dekker Inc., NY, 1992:1-34.

13. Tyler HR, Tyler KL. Cushing: The book collector. In: Black P, Moore M, Rossitch E (Eds.). Harvey Cushing at the Brigham. Amer. Assoc. Neurological Surgeons, Park Ridge, IL, 1995.

14. Tyler KL, Tyler HR. Sir William Richard Gowers (1845-1915): Exhumation and decoding of his shorthand publications. In: Rose FC (Ed.): A short history of neurology. The British Contribution 1660-1910. Butterworth-Heinemann, Oxford,1999:208-221.

15. Tyler KL, Roberts D, Tyler HR. The shorthand publications of Sir William Richard Gowers. Neurology 55:289-293, 2000.

16. Tyler KL, Malessa R. The Goltz-Ferrier debates and the triumph of cerebral localizationist theory. Neurology 55:1015-1024, 2000.

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17. Tyler KL. Gowers, William Richard In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:481-484.

18. Tyler KL. Mitchell, Silas Weir. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 3:183-190.

19. Tyler KL. Goltz, Friedrich Leopold. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:479-480.

20. Tyler KL. Hitzig, Eduard. In: Aminoff MJ, Daroff RB (Eds.). Encyclopedia of the neurological sciences. Academic Press, Amsterdam, 2003: vol. 2:560-561.

21. Tyler KL, York GK, Steinberg DA et al. History of 20th century neurology: decade by decade. Ann Neurol 53 (suppl 4): S27-S45, 2003.

22. Tyler KL. Origins and early descriptions of “Duchenne muscular dystrophy”. Muscle & Nerve 28:402-422, 2003.

23. Tyler KL. William Richard Gowers (1845-1915). J Neurol. 250:1012-1013, 2003.

24. Tyler KL. A history of bacterial meningitis. In: Finger S, Boller F, Tyler KL (Eds.): History of Neurology, Handbook of Clinical Neurology, 3rd Series, Elsevier, NY, 2010: 95:417-433.

25. Tyler KL and Tyler HR. The appointment of Dr. Derek Denny-Brown as head of the Neurologic Unit at Boston City Hospital and Harvard Medical School. In: The Cradle of American Neurology: The Harvard Neurological Unit at the Boston City Hospital, Dawson DM, Sabin TD (Eds.), HoLLis Publishing, Hoollis NH, 2011:63-81

26. Tyler KL, Goltz, Fredrich Lopold. In Encyclopedia of the Neurological Sciences (2nd edition), Daroff RB, Aminoff MJ (Eds). Elsevier, NY, 2014: vol. 2: 469-470.

27. Tyler KL. Gowers, William Richard in Encyclopedia of the Neurological Sciences (2nd ed), Daroff RB, Aminoff MJ (Eds). Elsevier, NY, 2014, vol. 2:471-474.

28. Tyler KL. Hitzig, Eduard. In Encyclopedia of the Neurological Sciences (2nd edition) Elsevier, Daroff RB, Aminoff MJ (Eds). NY, 2014: vol. 2:580-581.

29. Tyler KL. Mitchell, Silas Weir In: Encyclopedia of the Neurosciences (2nd edition). Daroff MB, Aminoff MJ (Eds.), Elsevier, NY 2014: vol. 2:78-80

.

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III. Book Chapters

1. Folkman J, Tyler K. Tumor Angiogenesis: Its Possible Role in Metastasis and Invasion. In: Day SB, Stacey B. et al. (ed.). Progress in Cancer Research and Therapy, Vol. 5. Cancer Invasion and Metastasis: Biological Mechanisms and Therapy. Raven Press. NY, 1977:95-103.

2. Tyler KL, Tyler HR. Huntington's Disease. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume I), 1978:116-141.

3. Tyler HR, Tyler KL. Parkinson's Disease. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume I), 1978:142-165.

4. Tyler KL. Huntington's Disease Update. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume II), 1979:157-167.

5. Tyler KL. Parkinson's Disease Update. In: Tyler HR and Dawson D (Eds.). Current Neurology. Houghton Mifflin, Boston, (Volume II), 1979:168-181.

6. Tyler KL, Tyler HR. Neurologic Complications of Uremia. In: Eknoyan G, Knochel J (Eds.) Systemic Consequences of Renal Failure. Grune & Stratton, 1984:311-330.

7. Tyler KL. Seizures. In: Hyman S (Ed.). Manual of Psychiatric Emergencies. Little Brown, Boston, 1984:161-169.

8. Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (Eds.): Virology. Raven Press, NY, 1985:817-822.

9. Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN,Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE (Eds.): Virology. Raven Press, NY, 1985:823-863.

10. Tyler KL, Fields BN. Reoviruses. In: Fields BN and Knipe DM (Eds.): Fundamental Virology. Raven Press, NY, 1986:391-395. [republication of #8]

11. Tyler KL, Fields BN. Reovirus and its Replication. In: Fields BN and Knipe DM (Eds.): Fundamental Virology. Raven Press, NY, 1986:397-436. [republication of #9]

12. Tyler KL, Tyler HR. Neurologic Manifestations of Endocrine Diseases. In: Asbury A, McKahn G, McDonald WI (Eds.). Diseases of the Nervous System. Saunders, Philadelphia, 1986:1552-1562.

13. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Infectious Disease. Kass EH, Platt R (Eds.). BC Decker, Philadelphia, 1986:216-225.

14. Tyler KL, Fields BN. Reovirus Infections in Laboratory Rodents. In: Bhatt PN et al. (Eds.). Viral and Mycoplasmal Infections of Laboratory Rodents: Effects on Biomedical Research. Academic Press, NY, 1986:277-303.

15. Tyler KL, Fields BN. Principles of Virology. In: Braunwald E, Isselbacker J, Petersdorf RG et al. (Eds.). Harrison's Principles of Internal Medicine (11th edition), McGraw Hill,

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NY, 1987:659-668.

16. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Internal Medicine-2. Bayless TM, Brain MC, Cherniak RM (Eds.). BC Decker, Philadelphia, 1987:231-240. [republication of #13]

17. Tyler KL. Encephalitis. In: Adelman G. (Ed.). Encyclopedia of Neuroscience. Birkhauser, Boston, 1987:387-389.

18. Tyler KL. The Neurologic Examination (Chapter 151), Aphasia (Chapter 154), Epilepsy (Chapter 156), Multiple Sclerosis (Chapter 161), Parkinson's Disease (Chapter 162), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 167), Amyotrophic Lateral Sclerosis (Chapter 168), Alcoholism (Chapter 176). In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JB, Fauci AS (Eds.). Harrison's Principles of Internal Medicine (11th ed.) Companion Handbook. McGraw-Hill, NY, 1988.

18. Tyler KL. Host and Viral Factors Which Influence Viral Neurotropism. In: Harding A and Rosenberg R (Eds.). The Molecular Biology of Neurological Disease. Butterworths, London, 1988:94-108.

20. Tyler KL, Fields BN. Reovirus Infections of the Central Nervous System. In: Johnson RT, Lyon G (Eds.). Viral Infections of the Developing Nervous System. Kluwer, Dordecht, 1988:11-19.

21. Tyler KL, Fields BN. Reoviridae: The Reoviruses. In: Lennette EH, Halonen P, Murphy FA (Eds.). Laboratory Diagnosis of Infectious Disease, Principles and Practice (Vol. II). Springer-Verlag, NY, 1988:353-374.

22. Tyler KL, Fields BN. Pathogenesis of Neurotropic Viral Infections: In: McKendall RR (Ed.). Viral Disease (Handbook of Clinical Neurology, revised series, Vol. 12(56). Elsevier, Amsterdam 1989:25-49.

23. Tyler KL. Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.). Virology (2nd ed.), Raven Press, NY 1990:191-239.

24. Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM (Eds.). Virology (2nd ed.), Raven Press, NY, 1990:1271-1273.

25. Tyler KL. Fields BN. Reoviruses. In: Fields BN, Knipe DM (Eds.).Virology (2nd ed.), Raven Press, NY, 1990:1307-1328.

26. Lehrich JR, Tyler KL. Slow Infections of the Central Nervous System. In: Mandell GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.). Churchill Livingstone, NY 1990:769-777.

27. Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandell GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1124-1134.

28. Tyler KL. Prions. In: Mandel GL, Douglas RG, Bennett JE (Eds.). Principles and Practice of Infectious Diseases (3rd ed.), Churchill Livingstone, NY 1990:1419-1423.

45

29. Tyler KL. Infections: Viruses. In: Pearlman AL and Collins R (Eds.). Neurobiology of Disease. Oxford Univ. Press, NY 1990:435-453.

30. Tyler KL. Localized Infections of the Central Nervous System. In: Current Therapy in Internal Medicine (3rd ed.). Kassirer JP (Ed). BC Decker, Philadelphia 1991:199-209.

31. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM (Eds.). Fundamental Virology (2nd ed.), Raven Press, NY 1991:191-239. [republication of #23]

32. Tyler KL, Fields BN. Reoviridae: A Brief Introduction. In: Fields BN, Knipe DM (Eds.). Fundamental Virology (2nd ed.), Raven Press, NY, 1991:583-585. [republication of #24]

33. Tyler KL, Fields BN. The Biology of Viruses. In: Wilson J, Braunwald E, Isselbacher KJ, et al. (Eds.). Harrison's Principles of Internal Medicine (12th edition), McGraw Hill, NY, 1991:669-677.

34. Tyler KL. The Neurologic Examination (Chapter 154), Epilepsy (Chapter 157), Multiple Sclerosis (Chapter 162), Parkinson's Disease Chapter 163), Amyotrophic Lateral Sclerosis (Chapter l65), Chronic Progressive Myopathies and Muscular Dystrophies (Chapter 170), Aphasia (Chapter 173), Alcoholism (Chapter 179). In: Wilson JD, Braunwald E, Isselbacher KJ, et al., (eds.). Harrison's Principles of Internal Medicine (12th ed.) Companion Handbook. McGraw-Hill, NY, 1991.

35. Tyler KL, Martin JB, Scheld WM. Focal Suppurative Infections of the Central Nervous System. In: Tyler KL, Martin JB (Eds.): Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 157-175.

36. Martin JB, Tyler KL, Scheld WM. Bacterial Meningitis. In: Tyler KL, Martin JB (Eds): Infectious Diseases of the Central Nervous System, FA Davis, NY, 1993: 176-187.

37. Tyler KL. The Neurological Examination (Chapter 160), Epilepsy (Chapter 162), Viral Infections of the Nervous System, Including Slow Viruses (Chapter 166), Multiple Sclerosis (Chapter 167), Parkinson's Disease (Chapter 169), Motor Neuron Disease Including ALS (Chapter 170),Aphasia (Chapter 172), Myopathies and Muscular Dystrophies (Chapter 180), Alcoholism (Chapter 185). In: Isselbacher KJ, Braunwald E, Wilson JD, et al. (Eds.). Harrison's Principles of Internal Medicine (13th ed.) Companion Handbook, McGraw-Hill, NY, 1995.

38. Tyler KL. Pathogenesis. In: Webster RG, Granoff A (Eds). Encyclopedia of Virology, Academic Press, London, 1994: 1076-1083.

39. Tyler KL, Fields BN. The Biology of Viruses. In: Isselbacher KJ, Braunwald E, Wilson JD, et. al.(Eds.): Harrison's Principles of Internal Medicine (13th ed.). McGraw Hill, NY, 1994:768-776.

40. Tyler KL. Viral and Prion Diseases of the Nervous System. In: Isselbacher KJ, Braunwald E, Wilson J, Martin J, Fauci A, Kasper D (Eds.): Harrison's Principles of Internal Medicine (l3th edition), McGraw-Hill, NY, 1994: 2309-2320.

46

41. Tyler KL, Blume GM. Herpes Simplex Encephalitis. In: Feldman, E. (Ed.): Current Diagnosis in Neurology, Mosby-Yearbook Inc., St. Louis, Missouri, 1994: 88-92.

42. Tyler KL. Animal Models of Reovirus Infection. In: McKendall RR, Stroop WG (Eds.): Handbook of Neurovirology. Marcel Dekker, Inc., NY,1994: 671-679.

43. Tyler KL. Prion Diseases of the Central Nervous System. In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed). Churchill Livingstone, NY, 1995: 881-887.

44. Tyler KL, Fields BN. Introduction to Viruses and Virus Diseases. In: Mandel GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed), Churchill Livingstone, NY, 1995:1314-1325.

45. Tyler KL. Prions. In: Mandel GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (4th ed.), Churchill Livingstone, NY, 1995:1674-76.

46. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM, Howley PM (Eds.) Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:173-218.

47. Tyler KL, Fields BN. Reoviruses. In: Fields BN, Knipe DM, Howley PM (Eds.): Virology (3rd ed). Lippincott-Raven, Philadelphia, 1996:1597-1623.

48. Tyler KL, Fields BN. Pathogenesis of Viral Infections. In: Fields BN, Knipe DM, Howley PM (Eds). Fundamental Virology (3rd ed.), Lippincott-Raven, Philadelphia,

1996:161-206. [republication of #46]

49. Pfister HW, Tyler KL. Other Spirochetal Infections. In: Brand T, Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:423-432.

50. Malessa R, Tyler KL. Viral Infections of the Central Nervous System. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological Disorders: Course and Treatment, Academic Press, San Diego, 1996:443-454.

51. Nathanson N, and Tyler KL. Entry, Dissemination, Shedding, and Transmission of Viruses. In: Nathanson N (Ed.) Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:13-33.

52. Virgin HW IVth, Tyler KL, Dermody TS. Reovirus. In: Nathanson N (Ed.). Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:669-699.

53. Tyler KL, Gonzalez-Scarano F. Viral Diseases of the Central Nervous System: Acute Infections. In: Nathanson N (Ed.). Viral Pathogenesis, Lippincott-Raven, Philadelphia, 1997:837-853.

54. Nathanson N. and Tyler KL. The Pathogenesis of Viral Infections. In: Collier L (ed.). Topley & Wilson's Microbiology and Microbial Infections (9th ed.), Vol. I: Mahy BWJ, Collier LH (Eds.). Virology, Edward Arnold, London, 1997:149-172.

47

55. Tyler KL. Aseptic meningitis, viral encephalitis, and prion diseases. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (Eds.). Harrison’s Principles of Internal Medicine (14 th ed.) , McGraw-Hill, NY, 1998:2439-2451.

56. Tyler KL. The Neurological Examination (Chapter 171), Bacterial Infections of the Central Nervous System (Chapter 176), Aseptic Meningitis, Viral Encephalitis, and Prion Diseases (Chapter 177), Motor Neuron Disease, Including ALS (Chapter 182), Aphasia (Chapter 183). In: Fauci AS, Braunwald E, Isselbacher KJ, et al. (Eds.) Harrison’s Principles of Internal Medicine (14 th ed.) Companion Handbook , McGraw-Hill, NY, 1998.

57. Tyler KL. Prognosis of acute viral encephalitis. In: Gilchrist JM (Ed). Prognosis in Neurology. Butterworth-Heinemann, Boston,1998:233-238.

58. Tyler KL, Encephalitis. In Adelman G., Smith BH (Eds.). Encyclopedia of Neuroscience (2nd ed.) Elsevier, Amsterdam, 1999:646-649.

59. Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith B (Eds.). Encyclopedia of Neuroscience (2 nd edition) , Elsevier Science, Amsterdam, 1999:1145-1148.

60. Tyler KL, Pathogenesis. In: Granoff A, Webster RG (Eds.). Encyclopedia of Virology (2 nd ed.) , Academic Press, London, 1999:1175-1184.

61. Tyler KL, Reovirus: General features. In: Webster RG, Granoff A (Eds.). Encyclopedia of Virology (2 nd ed.) , Academic Press, London,1999:1454-1464.

62. Tyler KL. Prion diseases of the central nervous system. In: Swartz MN, Remington JS (Eds.). Current Clinical Topics in Infectious Disease (19th ed.), Blackwell Science, Malden, MA 1999:226-251.

63. Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL, Bennett JE, Dolin R (Eds.) Principles and Practice of Infectious Diseases (5 th ed.), Churchill Livingstone, Philadelphia, 2000:1536-1552.

64. Tyler KL. Prions and prion diseases of the central nervous system (Transmissible neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (5 th ed.) , Churchill Livingstone, Philadelphia, 2000:1971-1985.

65. Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD (Eds.). Neurology in Clinical practice (3 rd edition) , Butterworth-Heinemann, Boston 2000:823-840.

66. Debiasi R, Tyler KL. Recurrent aseptic meningitis. In: Davis LE, Kennedy PGE (Eds.). Infectious diseases of the nervous system, Butterworth Heinemann, Oxford England, 2000:445-479.

67. Tyler KL. Diseases of the central nervous system caused by prions-I. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006]

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68. Tyler KL. Diseases of the central nervous system caused by prions-II. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006].

69. Tyler KL. Prions. In Rose BD (Ed.). UpToDate, [Infectious Disease Section, M. Hirsch, Ed.] (CD-ROM). Up To Date Inc., Wellesley, MA. 2000 [Updates 2001-2006].

70. Roos KL, Tyler KL. Bacterial meningitis and other suppurative infections. In: Braunwald E, Fauci AS, Kasper DL, Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2462-2471.

71. Tyler KL. Viral meningitis and encephalitis. In: Braunwald E, Fauci AS, Kasper DL, Hauser SI, Longo DI, Jameson JL (Eds.). Harrison’s Principles of Internal Medicine (15th edition). McGraw-Hill, NY:2001:2471-2481.

72. Tyler KL, Nathanson N. Pathogenesis of viral infections. In: Knipe DM, Howley PM, et al. (Eds.) Fields Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia, 2001: 199-243.

73. Tyler KL. Mammalian Reoviruses. In: Knipe DM, Howley PM, et al. (Eds.) Fields Virology (4th edition), Lippincott-Williams & Wilkins, Philadelphia , 2001:1729-1745.

74. Tyler KL, Pathogenesis of viral infections. In: Knipe DM, Howley PM (Eds.). Fundamental Virology (4th edition), Lippincott-William & Wilkins, Philadelphia, 2001:199-243. [republication of #72]

75. DeBiasi R, Tyler KL. Viral meningitis and encephalitis. Infectious Disease, Continuum 8: 59-87, 2002 (American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia).

76. Malessa R, Tyler KL. Acute viral infections of the nervous system. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C (Eds.). Neurological disorders: Course and treatment, 2nd edition. Academic Press, Amsterdam, 2003:601-613.

77. DeBiasi RL, Tyler KL. Infections of the nervous system. Viral infections. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:1515-1543.

78. Corboy JR, Tyler KL. Neurovirology. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds.). Neurology in Clinical practice (4th edition), Butterworth-Heinemann, Philadelphia, 2004:831-848.

79. Tyler KL. Acute viral myelitis. In: Scheld M, Whitley RJ, Marra CM. Infections of the central nervous system (3rd edition). Lippincott William & Wilkins, Philadelphia, 2004:305-322.

80. Anderson CA, Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds.): Encyclopedia of Neuroscience, 3rd edition (CD-ROM), Elsevier, 2004.

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81. Tyler KL. Meningitis. In: Adelman G, Smith BH (Eds): Encyclopedia of Neuroscience, 3rd edition (CD-ROM), Elsevier, 2004.

82. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. Chapter 360. In: Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds). Harrison’s Principles of Internal Medicine (16th edition). McGraw Hill, Boston, 2005:2471-2490.

83. Dermody TS, Tyler KL. Introduction to viruses and viral diseases. In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6 th ed.) , Churchill Livingstone, Philadelphia, 2005:1729-1742.

84. Tyler KL. Prions and prion diseases of the central nervous system (Transmissible neurodegenerative diseases). In: Mandell GL, Bennett JE, Dolin R (Eds.). Principles and Practice of Infectious Diseases (6 th ed.) , Churchill Livingstone, Philadelphia, 2005:2219-2235.

85. Tyler KL, Anderson CA. Biology and genetics of prions. UpToDate. (CD-ROM) Ver 13.2, 2005. (see also 67-69 for earlier editions)

86. Tyler KL, Anderson CA. Diseases of the nervous system caused by prions. UpToDate (CD-ROM), Ver 13.2, 2005. (see also 67-9 for earlier versions)

87. Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver 13.2, 2005 (see also #67-9 for earlier versions)

88. Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. UpToDate (CD-ROM), Ver 13.2, 2005 (see also #67-9 for earlier versions)

89. Nathanson N, Tyler KL. Pathogenesis of Viral Infections. In: Collier L (Ed.). Topley & Wilson's Microbiology and Microbial Infections (10th ed.), Vol. I: Virology; Mahy BWJ, ter Meulen V (Eds.). Hodder Arnold & ASM Press, London, 2005:236-269.

90. Gilden DH, Tyler KL. Herpesvirus infection and peripheral neuropathy. In: Dyck PJ, Thomas PK (Eds.). Peripheral neuropathy (4th edition), Elsevier Saunders, Philadelphia, 2005:2117-2127.

91. DeBiasi R, Tyler KL. Viral meningitis and encephalitis. In: Infectious Disease, Continuum (American Academy of Neurology, published by Lippincott Williams & Wilkins, Philadelphia), 12(2): 58-94, 2006.

92. Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess, and empyema. In: Hauser SL (Ed.): Harrison’s Neurology in Clinical Medicine. McGraw-Hill, NY, 2006:423-455. (updated reprinting of #82)

93. Brown HG, Lee JM, Tyler KL, Anderson CA. Creutzfeldt-Jakob Disease. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)

94. Brown HG, Lee JM, Tyler KL, Anderson CA. Variant Creutzfeldt-Jakob Disease. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)

95. Brown HG, Lee JM, Tyler KL, Anderson CA. Diseases of the central nervous system

50

caused by prions. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)

96. Brown HG, Lee JM, Tyler KL, Anderson CA. biology and genetics of prions. In: UpToDate (CD-ROM), Ver 14.2, 2006. (see #67-9, 85-8 for earlier versions)

97. Anderson CA, Tyler KL. Prion diseases. Chapter 56, In: Engleberg NC, DiRita V, Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:534-540.

98. DeBiasi RL, Tyler KL. Infections of the central nervous system. Chapter 61, In: Engleberg NC, DiRita V, Dermody TS (Eds.): Schaechter’s Mechanisms of Microbial Disease, 4th edition, Lippincott William & Wilkins, Philadelphia, 2007:588-602.

99. Schiff LA, Nibert M, Tyler KL. Orthoreoviruses and their replication. In: Knipe DM, Howley PM (Eds.): Fields’ Virology (5th edition), Lippincott William & Wilkins, Philadelphia, 2007:1853-1915.

100. Solbrig MV, Tyler KL. Infections of the nervous system: Viral infections (Chapter 57B). In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J. (Eds.): Neurology in Clinical Practice, 5th edition, Butterworth-Heinemann Elsevier, Philadelphia, 2008:1457-1488.

101. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema. In Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (17th edition), McGraw Hill, NY, 2008:2621-2641.

102. Tyler KL, Gilden DH. Clinical management of viral encephalitis (Chapter 19). In: Reiss C (Ed.). Neurotropic viral infections. Cambridge University Press, 2008:347-361.

103. Beckham JD, Tyler KL. Clinical manifestations of neurological disease. In: Diamond M (Ed.): West Nile encephalitis virus infection: pathogenesis and the host immune response. Springer, NY, 2009:69-95.

104. DeBiasi R, Tyler KL. Orthoreoviruses and orbiviruses. In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2097-99.

105. DeBiasi R, Tyler KL. Coltiviruses and seadornaviruses (Colorado Tick Fever). In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Elsevier, NY, 2009:2101-3.

106. Bosque P, Tyler KL. Prions and prion diseases of the nervous system (Transmissible neurodegenerative diseases) In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Churchill-Livingstone, Philadelphia, 2010:2423-2438.

107. Beckham JD, Tyler KL. Encephalitis. In: Mandell GL, Bennett JE, Dolin R (Eds): Principles and practice of infectious diseases (7th ed). Churchill-Livingstone, Philadelphia, 2010:1243-1263.

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108. Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess and empyema.

In: Hauser SL (Ed). Harrison’s Neurology in Clinical Medicine (2nd edition). McGraw Hill, NY, 2010: 451-483.

In: Kasper DL, Fauci AS. Harrison’s Infectious Disease. McGraw Hill, NY, 2010: 303-332

109. Kleinschmidt-DeMasters BK, Tyler KL. Infections and Inflammatory Disorders. In: Perry A and Brat DJ (Eds). Practical surgical neuropathology: A diagnostic approach. Churchill Livingstone Elsevier, NY, 2010:455-484.

110. Beckham JD, Solbrig ML, Tyler KL. Viral encephalitis and meningitis. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds): Neurology in Clinical Practice (6th edition), Elsevier, Philadelphia, 2010.

111. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema (Chapter 381). In Longo D, Fauci AS, Kasper D, Hauser S, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (18th edition), McGraw Hill, NY, 2011:3410-34.

112. Anderson CA, Tyler KL. Prion disease (Chapter 56), In: Engleberg NC, DiRita V,

Dermody TS (Eds): Mechanisms of microbial disease (5th edition). Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2013: 552-559.

113. DeBiasi R, Tyler KL. Infections of the central nervous system (Chapter 61). In: Engleberg NC, DiRita V, Dermody TS (Eds): Mechanisms of microbial disease (5th edition). Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, 2013: 612-627.

114. Oyer R, Beckham JD, Tyler KL. West Nile and St. Louis encephalitis viruses (Chapter 20). In: Tselis AC and Booss J (Vol. Eds.) Neurovirology, Handbook of Clinical Neurology (vol. 123, 3rd series) (Aminoff MJ, Boller F, Swaab DF Series Editors), Elsevier, Edinburgh, 2014:433-447. [PMCID24722324].

115. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema (Chapter 164). In Kasper D, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (19th edition), McGraw Hill, NY. 2015:883-906.

116. Beckham JD, Tyler KL. Encephalitis (Chapter 91). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:1144-1163.

117. Debiasi RL, Tyler KL. Orthoreoviruses and orbiviruses (Chapter 150). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:1848-50.

118. Debiasi RL, Tyler KL. Coltiviruses and Seadornaviruses (Chapter 151). In: Bennett JE, Dolin R, Blaser M (Eds): Principles and practice of infectious diseases (8th edition), Churchill Livingstone (Elsevier), Philadelphia, 2015:1851-3.

119. Bosque PJ, Tyler KL., Prion and prion diseases of the ventral nervous system (Transmissible neurodegenerative diseases)(Chapter 181), In: Bennett JE, Dolin R, Blaser

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M (Eds): Principles and practice of infectious diseases (8th edition), Elsevier, Philadelphia, 2015:2142-53.

120. Roos K, Tyler KL. Meningitis, encephalitis, brain abscess and empyema, In Kasper D, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J (Editors): Harrison’s principles of internal medicine (20th edition), McGraw Hill, NY. 2017 (in press).

IV. Books

1. Tyler KL, Martin JB (Eds). Infectious Diseases of the Central NervousSystem. Contemporary Neurology Series 41. FA Davis, Philadelphia,1993.

2. Tyler KL, Oldstone MBA (Eds). Reoviruses I: Structure, Proteins and Genetics. . Current Topics in Microbiology & Immunology Vol. 233/1, Springer-Verlag, Heidelberg, 1998.

3. Tyler KL, Oldstone MBA (Eds.). Reoviruses II: Cytopathogenicity and Pathogenesis. Current Topics in Microbiology and Immunology. Vol. 233/2, Springer-Verlag, Heidelberg, 1998.

4. Tyler KL. Associate Editor, Aminoff MJ, Daroff RB (Editors): Encyclopedia of the Neurological Sciences, Academic Press, Amsterdam, 2003.

5. Finger S, Boller F, Tyler KL (Eds). History of Neurology. Handbook of Clinical Neurology, vol. 95, 3rd Series (Aminoff MJ, Boller F, Swaab DF Series Editors). Elsevier, Amsterdam, 2010.

V. Editorials & Commentaries

1. Tyler KL. Prions [editorial] Infections in Medicine 11:382-383, 1994.

2. Tyler KL, Diagnosis of herpes simplex encephalitis: Application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. [commentary] Neurology Network Commentary 1:9-13, 1997.

3. Tyler KL, Cerebrospinal-fluid polymerase chain reaction and the diagnosis of viral infections of the central nervous system. [commentary] Neurology Network Commentary 1:276-282, 1997.

4. Tyler KL, Rabies [commentary]. Neurology Network Commentary 3:64-67, 1999.

5. Tyler KL. Viruses in Amyotrophic Lateral Sclerosis. [commentary] Lancet Neurology Network 4:1, 2001 (e-published at www.lancetneuronet.com).

6. Tyler KL. West Nile Virus encephalitis in America . [editorial] N Engl J Med 344: 1858-1859, 2001.

7. Tyler KL, McArthur JC. Through a glass darkly: The role of CSF viral load (HIV-1 RNA) measurements in understanding the pathogenesis of HIV infection of the CNS. [editorial].

53

Arch Neurol 59:909-912, 2002.

8. Tyler KL. Creutzfeldt-Jakob Disease [editorial perspective]. N Engl J Med. 348: 681-682, 2003.

9. Tyler KL. Human herpesvirus 6 and multiple sclerosis [editorial]. J Infect Dis. 187:1360-1364, 2003.

10. Tyler KL. The uninvited guest. JC virus infection of neurons in PML [editorial]. Neurology 61:734-735, 2003.

11. Tyler KL. Commentary: Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC. Oral transmission of Kuru, Creutzfeldt-Jakob disease, and scrapie to non-human primates. J Infect Dis 1980; 142:205-208. [Centennial Perspective]. J Infect Dis 190:653-660, 2004.

12. Davis LE, Tyler KL. Molecular diagnosis of CNS viral infections. [editorial commentary]. Journal of Neurology, Neurosurgery, and Psychiatry 76:10, 2005. [PMC1739295]

13. Tyler KL. Rabies in four organ transplant recipients [article commentary]. Journal Watch Neurology (from the publishers of the N Engl J Med) 7:55, 2005.

14. Gilden DH, Tyler KL. Bell’s palsy- Is glucocorticoid treatment enough? [editorial]. N. Engl. J. Med. 357:1653-5, 2007.

15. Tyler KL. Bacterial meningitis: An urgent need for further research to reduce mortality and morbidity [editorial]. Neurology 70:2095-6, 2008.

16. Bosque PJ, Tyler KL. Prions’ travels-Feces and transmission of prion diseases. [editorial] J. Infect. Dis. 198:8-9. 2008.

17. Tyler KL. Cortical demyelination in MS and progressive multifocal leukoencephalopathy [article commentary]. Journal Watch Neurology (from publishers of the N Engl J Med) 10:51, 2008.

18. Tyler KL. PML’s 50th birthday- New insights into pathogenesis [editorial]. Annals Neurol. 64:359-61, 2008.

19. Tyler KL. Progressive Multifocal Leukoencephalopathy: Can we reduce risk in patients receiving biological immunomodulatory therapies? [editorial] Annals Neurol. 68: 271-274, 2010.

20. Tyler KL. PML therapy: “It’s Déjà vu all over again” [editorial]. J. Neurovirol. 19:311-313, 2013.

21. Steiner I, Tyler KL. The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis [editorial]. Neurology 83:1882-3, 2014. [PMID25339218].

22. Tyler KL. Fingolimod and risk of varicella-zoster virus infection: Back to the future with an old infection and a new drug.[editorial]. JAMA Neurol. 72:10-13, 2015 [PMID25420159].

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23. Tyler KL. Failure of adjunctive valacyclovir to improve outcomes in Herpes Simplex encephalitis. Clin Infect Dis 61:692-4, 2015. {PMID25956893]

24. Tyler KL, Pastula DM: Hepatitis E Virus and Guillain-Barre syndrome [editorial]. JAMA Neurology (2016 Nov 7. doi: 10.1001/jamaneurol.2016.3651. [Epub ahead of print]) [PMID27720625]

VI. Other Products of Scholarship (Audio cassette recordings, Book reviews, Obituaries)

1. Tyler KL. Lawrence C McHenry Jr (1929-1985).[Obituary] Archives Neurology 42:1202-1203, 1985.

2. Tyler KL. Therapy of viral diseases of the central nervous system.[Audio cassette recording]. Clinical Neuroscience Review (Stanley H. Appel, editor), #307, 1985.

3. Tyler KL. Molecular basis of viral neurovirulence. [Audio cassette recording] Clinical Neuroscience Review (Stanley H. Appel, editor), #604, 1986.

4. Tyler KL. An Early History of Craniotomy: From Antiquity to the Napoleonic Era by L Bakay. [book review] Neurology 36:1013-1014, 1986.

5. Tyler KL. Founders of Child Neurology, Ashwal S (Ed.). [book review] Annals Neurology 30:856, 1991.

6. Tyler KL. Molecular Neurovirology, Roos R (Ed). [book review] J. Neurol. Sci. 118:223, 1993.

7. Tyler KL, Viral Infections of the Nervous System (2nd ed.), Johnson RT, [book review]Annals Neurology 45:549, 1999.

8. Tyler KL, [book review]. Segmented double-stranded RNA viruses: structure and molecular biology. Paton JT (Ed.) [book review] Lancet Infectious Disease, 8:224, 2008.

9. Tyler KL, Martin JB. H. Richard Tyler, M.D. (1927-2016). In Memorium. Neurology 87:1434-5, 2016.

10. Tyler KL, Samuels MA. In memorium: H. Richard Tyler, M.D. (1927-2016). JAMA Neurol 73:1378-80, 2016.

11. Lipton HK, Tyler KL. In memorium: Donald H. Gilden, M.D. J Neurovirol 22:551-2, 2016.

12. Tyler KL, Lipton HL. Donald H. Gilden, M.D. (1937-2016). Neurology 87:2182-3, 2016.

VII. Published Syllabi and Guidelines:

1. Tyler KL, Neuroanatomy, neurophysiology, and neuropathology in 19th century France. History of Neurology (Course #231, K.L. Tyler, Director), American Academy of

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Neurology, Chicago, 1989.

2. Tyler KL, Introduction to the history of neurology in the 18th and early 19th centuries. History of Neurology (Course #425, K.L. Tyler, Director), American Academy of Neurology, Miami Beach, 1990.

3. Tyler KL, Diagnosis of aseptic meningitis and encephalitis. Infections of the Nervous System (Course #246, R.T. Johnson, Director), American Academy of Neurology, Boston, 1991

4. Tyler KL, Introduction to the history of neurology in the 18th century and early 19th centuries. History of Neurology (Course #220, K.L. Tyler, Director), American Academy of Neurology, Boston, 1991.

5 Tyler KL, The recurrent meningitis syndrome. Infections of the Nervous System I (Course #121, P. Coyle, Director), American Academy of Neurology, Seattle, 1995.

6. Tyler KL, Treatment of acute herpes virus infections of the nervous system. Therapy in Neurology I (Course #126, A.E. Miller, Director), American Academy of Neurology, Seattle, 1995.

7. Tyler KL, Viral meningitis and encephalitis. Infections of the Nervous System I (Course #223, C. Marra, Director), American Academy of Neurology, Boston, 1997.

8. Tyler KL, Neurology in Boston: From the Winthrop Fleet (1630) to the mid-19th Century. Bostonian Neurological History Revisited (Course #365, S. Mishra, Director), American Academy of Neurology, Boston, 1997.

9. Tyler KL, Intracranial subdural empyema and epidural abscess. Infections of the Nervous System I (Course #7FC006, C. Marra, Director), American Academy of Neurology, Minneapolis, 1998.

10. Tyler KL, William Alexander Hammond (1828-1900). Origins of American Neurology (Course #3PC.008, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1998.

11. Tyler KL, Silas Weir Mitchell (1829-1914). Origins of American Neurology (Course #3PC.008, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1998.

12. Tyler KL, Herpes simplex virus infections of the nervous system. Infections in the Nervous System. (Course #3FC.004, C. Marra, Director), American Academy of Neurology, Minneapolis, 1999.

13. Tyler KL, William Richard Gowers (1845-1915). Masters of Neurology: The 19th Century. (Course #4PC.003, E. Pappert, Director), American Academy of Neurology, Minneapolis, 1999.

14. Tyler KL, Clash of the Titans: The Goltz-Ferrier debates and the triumph of cerebral localizationist theory. Clash of the Titans: The Great Debates of 19th Century Neurology (Course #5PC.002, E. Louis, Director), American Academy of Neurology, San Diego, 2000.

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15. Tyler KL, Bacterial Brain Abscess. Infections of the Nervous System (Course #2FC.004, C. Marra, Director), American Academy of Neurology, San Diego, 2000.

16. Tyler KL. Recurrent Viral Meningitis and Chronic Viral Encephalitis. Neurovirology (Course #3AC.005, R. Johnson, Director), American Academy of Neurology, Denver, 2002.

17. Tyler KL. Acute Viral Encephalitis. Infections of the Nervous System (Course #7FC.003, K. Roos, Director), American Academy of Neurology, Denver, 2002.

18. Tyler KL, William Richard Gowers (1845-1915). An evening with great books from the AAN history of neurology archives (Course #2DS.005, K.L. Tyler, director), American Academy of Neurology, Denver, 2002.

19. Tyler KL. Update on Herpes simplex virus encephalitis. Neurovirology (Course #7PC.006, K. Tyler, Director), American Academy of Neurology, Honolulu, 2003.

20. Tyler KL, Acute viral encephalitis. Infections of the Nervous System (3FC.002, K. Roos, Director), American Academy of Neurology, San Francisco, 2004.

21. Tyler KL, Unusual manifestations of infectious diseases. Unusual manifestations of infectious diseases (Course #3AS.008, J. Berger, Director), American Academy of Neurology, San Francisco, 2004.

22. Tyler KL, Seminal cases in frontal lobe function: The American crowbar case. Seminal Cases in the History of Neurology (Course #4PC.003, V. Henderson, Director, American Academy of Neurology, Miami Beach, 2005)

23. Tyler KL, West Nile virus. The Neurological complications of emerging infections and bioterrorism. (Course #4BS.002, J. Berger, Director, American Academy of Neurology, Miami Beach, 2005).

24. Tyler KL, Nipah and Hendra viruses. The Neurological complications of emerging infections and bioterrorism. (Course #4BS.002, J. Berger, Director, American Academy of Neurology, Miami Beach, 2005).

25. Tyler KL, Nipah and Hendra Viruses. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.007, J. Berger, Director, American Academy of Neurology, San Diego, 2006).

26. Tyler KL, West Nile virus. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.007, J. Berger, Director, American Academy of Neurology, San Diego, 2006).

27. Tyler KL, Acute viral encephalitis. Infections of the nervous system. (Course #7FC.005, A. Aksamit, Director, American Academy of Neurology, San Diego, 2006).

28. Tyler KL, West Nile virus. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.005, J. Berger, Director, American Academy of Neurology, Boston, 2007).

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29. Tyler KL, Japanese encephalitis. Neurological Complications of emerging infections and bioterrorism. (Course #3DS.005, J. Berger, Director, American Academy of Neurology, Boston, 2007).

30. Tyler KL, West Nile virus. Infections of the nervous system. (Course #7FC.003, R. Bartt, Director, American Academy of Neurology, Chicago, 2008).

31. Tyler KL. Acute viral encephalitis. Therapy in neurology. (Course 3FC.002, S. Fahn, Director, American Academy of Neurology, Toronto, 2010).

32. Tyler KL. Acute viral encephalitis. Infections of the nervous system. (Course #3FC.006, R. Bartt, Director). American Academy of Neurology, Honolulu, 2011.

33. CDC. Acute flaccid myelitis: interim considerations for clinical management. Centers for Disease Control (CDC)(posted 7 November, 2014; http://www.cdc.gov/ncird/downloads/acute-flaccid-myelitis.pdf)Participants: Abzug M, Jackson M, Byington C, Clark R, Dominguez S, Glaser C, Jackson M, Larsen G, Laughlin C, Modlin J, Messacar K, Sawyer M, Schreiner T, Simon D, Tyler KL, van Haren K, Waubant E, Wizniter M. CDC Participants: Sejvar J, Pastula D, Cortese M, Feiken D, Leshan E, Oberste S, Pallansch M, Seward J.

34. Tyler KL. Diagnosis and Management of Acute Viral Encephalitis. (Course C28: Infectious, Paraneoplastic, Autoimmune?, 67th Annual Meeting, American

Academy of Neurology, Washington, DC. April, 2015

35. Tyler KL. Update in Acute Viral Encephalitis. (Course C37: Neurology Update I), 67th Annual Meeting, American Academy of Neurology, Washington DC. April, 2015

36. Tyler KL, Update in Neurologic Infections (Course C40: Neurology Update I, 69th Annual

Meeting, American Academy of Neurology, Boston, MA. 2017

Doctoral Students

Sarah Stonedahl, B.S (Microbiology, Colorado State University). Graduate Student-Immunology-Microbiology Program. 2017-Thesis project: TBD

Alison Hixon, B.A., (Psychology, University of Montana), Graduate Student, Immunology-Microbiology) Program & M.D., PhD. Medical Scientist Training Program 2015-Thesis project: Pathogenesis of Enterovirus D-68 infection

Scott Seitz, B.S. (Biology, University of Colorado), Graduate Student, Immunology-Microbiology Program, 2013-Thesis project: Role of RLR-like helicases and exosomes in the pathogenesis of flavivirus CNS infection

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Eamon Quick, (Ph.D. Neuroscience Program, University of Colorado, 2017), Thesis: Investigations into antiviral microglial activation during West Nile virus infection of the Central Nervous System. Current position: TBD

Katherine Shives, (PhD, Immunology-Microbiology, University of Colorado, 2016),Thesis: mTOR complex-1 regulates translation initiation events of (+) sense RNA viruses. (co-advisor, David Beckham, M.D.)Current position: TBD

Kalen Dionne (PhD, Neuroscience Program 2012)(M.D., 2014)(Medical Scientist Training Program)Thesis: Modeling reovirus encephalitis in brain slice cultures for investigation of CNS-specific antiviral immunityCurrent position: Resident, Neurology Program, Washington University, St. Louis, MO

Stephanie Schittone, (PhD, Department of Microbiology, 2011)Thesis: Development and analysis of mechanisms of spinal cord injury in a novel model of viral myelitis. Current position: Visiting Professor, Department of Biology, Colorado College, Colorado Springs, CO

Heather Berens, (PhD Department of Microbiology, 2011)(M.D., 2013)(Medical Scientist Training Program)Thesis: The Bcl-2 family proteins Bax and Bak play important but separate roles in the pathogenesis of reovirus encephalitis.Current position: Rheumatology Fellow, Department of Medicine, University of Colorado School of Medicine

Angela Tollefson (nee Zimmerman) (PhD., Program in Neuroscience, 2007)Thesis: A novel mechanism underlying Bcl-2 antioxidant function: its role in mitochondrial apoptotic pathways and virus-induced neuronal cell death. Current: Instructor, Dept. Biological Sciences, Marquette University, Milwaukee, WI

Cristen Hoyt (Ph.D., Department of Immunology, 2004)Thesis: The reovirus non-structural protein sigma-1-small mediates alteration of a nuclear structure and is a determinant of virulence.Current: Clinical Science Manager, Abbott Immunology (Abbott Laboratories)

Sarah Richardson-Burns (Ph.D., Neuroscience Program, 2003)Thesis: Apoptosis in viral infection of the central nervous system and primary neuronal cultures.Current: Director, Research & Development, Biotectix LLC, MI

George Poggioli (Ph.D., Department of Microbiology, 2001)(M.D, 2003) (Medical Scientist Training Program)Thesis: reovirus-induced G2/M phase cell cycle arrestCurrent: Dermatology practice, CO

Masters Degree StudentMaria Latska Ibach (M.S., Physicians Assistants Training Program, 1998)Thesis: Isolation and characterization of a novel human reovirus associated with meningitis

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Current: private practice, Denver, CO

Postdoctoral Fellows

Yonghua Zhuang, M.D., Ph.D.Period: 7/1/2012-8/2017Degree: M.D., Tongji University Medical , Shanghai, China (2001), Ph.D. Immunology, West China Medical Center, Sichuan University, Chengdu, China (2009)Project: Role of p53 in Reovirus-induced apoptosisCurrent position: Graduate student Biostatatistics Graduate Program, University of Colorado

Ryan Oyer, M.D.Period: 2010-2012Degree: M.D. ,Univ. Colorado School of Medicine (2006); Residency, Internal Medicine Univ. CO, (2006-2009); Fellowship-Adult ID Training Program Univ. Colorado (2009-2012)Projects: Cytokine expression in human viral encephalitis, mechanisms of WNV induced autophagyCurrent Position: Infectious Disease Private Practice, Wheat Ridge, CO

John David Beckham, M.D.Period: 7/1/2005-2009Degree: M.D., Baylor, 2001Residency (Internal Medicine), Baylor 2001-2004Fellowship Adult Infectious Disease Training Program, University of Colorado, 2004-7Paid: VA Research Career Development Award, NIH K08Current Position: Associate Professor of Medicine & Neurology, UCHSC

Robin Goody, Ph.D.Period: 12/2002-4/2008Degree: Ph.D. (Pharmacology) University of Surrey, Guildford, U.K. (2000)Role of reactive oxygen species and calcium fluxes in reovirus-induced apoptosis in neuronal and non-neuronal systems, JAK-STAT signaling in reovirus infectionCurrent position: Senior Research Scientist, RxGen Inc., New Haven, CT

Cristen C. Hoyt, Ph.D.Period: 9/04-4/2006Degree: Ph.D. (Immunology), University of Colorado (2004)Identification and characterization of a nuclear export signal on reovirus sigma 1s proteinCurrent position: Senior Clinical Science Manager, Abbott Immunology

Eric Exelbert, M.D. Period: 7/1/2004- 6/2006Degree: M.D. East Carolina University, Brody School of Medicine (2003); Fellowship Pediatric Intensive Care (Children’s Hospital and UCHSC)(2003-6)Mechanisms of reovirus induced hepatocyte and liver injuryCurrent position: Director, Pediatric Critical Care, Pediatric Hospital Services of SW Florida

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Shelley Miyamoto, M.D.Period: 10/2003-10/2005Degree: M.D., University of Iowa (1998); B.S. University of Iowa (1993), Residency (Pediatrics), Rhode Island Hospital (1998-2002), Fellowship: Pediatric Cardiology (2003-5)Current position: Associate Professor of Pediatrics, Director Cardiomyopathy Program, Children’s Hospital Colorado, Univ. Colorado School of Medicine

Sarah Richardson-Burns, Ph.D.Period: 6/2003-12/2003 Degree: Ph.D. (Neuroscience), University of Colorado (2003)Reovirus induced apoptosis in neuronal cultures and in the murine CNSCurrent Position: Co-Founder & Director of Research & Development, Biotectix LLC, Ann Arbor, MI

Doug Kominsky, Ph.D.Period: 1/1999-7/2002Degree: Ph.D. (Molecular Biology) University of Wyoming (1998)Identification of caspase pathways activated during reovirus-induced apoptosisCurrent Position: Associate Professor, Dept. of Microbiology and Immunology, Montana State University

Penny Clarke, Ph.D.Period: 9/1/1997-2000Degree: Ph.D. University of Glasgow, Glasgow, Scotland (1990)Project: Signal transduction pathways and viral apoptosisCurrent position: Professor of Neurology, UCHSC

Roberta Debiasi, M.D.Period: 7/1/1997- 2000 (includes rotation during fellowship)Degree: M.D. University of Virginia (1992)Pediatric Residency U. California Davis (1993-5)Infectious Disease Fellowship, Univ. Colorado Health Sciences Center (1996-9)Project: Role of calpain in viral apoptosis and myocardial injury, reovirus genomics and proteonomicsCurrent position: Professor of Pediatrics (tenured), George Washington University and the Children’s National Medical Center, Washington, D.C. Director, Pediatric Infectious Diseases GW University School of Medicine

Stephanie Oberhaus, Ph.D.Period: 5/1994-7/1/1997Degree: PhD (Microbiology), University of North Carolina, Chapel Hill, NC (1994)Project: Reovirus-induced apoptosis in the murine CNSCurrent position: Assistant Professor of Microbiology, Boston University School of Medicine

Clinical Neuro-ID Fellows (Fellowship inaugurated in July, 2015). Daniel Smith, M.D. Period 7/1/2015- 6/30/2016Degree: B.S. Ohio State University (2007)M.D. U. of Cincinnati (2011)Neurology Resident & Chief Resident, U. Cincinnati (2011-15)

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Clinical K23 AwardeeKevin Messacar, M.D.Period: 9/1/2016-Degree: B.S., Univ. Michigan (2003), M.D. Univ. Michigan (2008),Pediatric Residency (2011) & ID Fellowship (2014), U. Colorado Sch. Med. Assistant Professor of Pediatrics (2014-)K23 AI128069: Implementation and effectiveness of a rapid CSF diagnostics program for children with suspected CNS infection

Graduate Student Doctoral Thesis Committees (UC SOM unless noted):

Stephanie Bonney, Julie Siegenthaler Laboratory, Cell Biology, Stem Cells & Development (2015, active). Reovirus encephalitis as a model of virus-induced blood-brain-barrier disruption

Katherine Shives, David Beckham laboratory, Department of Immunology-Microbiology (2016). mTOR complex-1 regulates translation initiation events of (+)sense RNA viruses.

John Soltys, Jeffrey Bennett Laboratory, Neuroscience Program (2016). A molecular model of classical complement activation by aquaporin-4 autoantibodies in neuromyelitis optica and pathway-specific contributions to central nervous system injury.

Alexandra Suffit, Amy Keating Laboratory, Cancer Biology Program (2015). Effects of receptor tyrosine kinase mer inhibition on glioblastoma.

Jaime Keane, Robert Garcea Laboratory, Department of Microbiology (2010). Seropeidemiology of human polyomaviruses and the detection of lymphotropic polyomavirus in human peripheral blood.

Elizabeth Brazeau, Ravi Mahalingham/Donald Gilden laboratory, Department of Microbiology Analysis of a varicella ORF 63 function in vivo.

Kevin Deibel, Linda van Dyk laboratory, Department of Molecular Biology (2010). Biogenesis and biological functions of the gammaherpesvirus 68 encoded MicroRNAs.

Hannah Townsend, David Barton Laboratory, Department of Microbiology (2008)A phylogenetically conserved RNA structure within the poliovirus 3C ORF competitively inhibits the antiviral ribonuclease L

Lisa Marie Williams, Linda VanDyk Laboratory, Department of Microbiology (2007). Cell Cycle Inhibitors in Regulation of gHV68 Reactivation.

Sonia Tusell, Kay Holmes Laboratory, Department of Microbiology (2007). Spike receptor interactions of group 1 coronaviruses and emerging coronaviruses.

Maria McClure, Kim Heidenreich Laboratory, Department of Pharmacology (2004)Elucidation of a novel autophagic death pathway in cerebellar Purkinje neurons that is regulated by death receptors and neurotrophins.

Brain Turner, Kay Holmes Laboratory, Department of Microbiology (2004)

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Interactions of murine coronavirus with its murine CEACAM1 receptors.

Laura Hermann, Kevin Coombs Laboratory, Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, Canada (External Examiner) (2004). Characterization of a novel reovirus and antiviral activity against mammalian reovirus.

Kyung-Won Huh, Aleem Siddiqui Laboratory, Department of Microbiology (2001)Characterization of hepatitis B virus x protein.

Tiffany White, Don Gilden Laboratory, Department of Microbiology (2001)Simian varicella zoster virus latent genes.

Jean Schickli, Ph.D., Kay Holmes Laboratory, Department of Microbiology (2000)Thesis: Characterization of the spike glycoprotein of a mouse hepatitis virus (MHV) host range variant.

Julie A. Lang, Ph.D., Nemazee Laboratory, Department of Immunology (1996)Thesis: The effect of antibody:antigen affinity, antigen concentration, and over-expression of bcl-2 on tolerance in immature and mature B-cells.

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