CURRICULUM VITAE TIMOTHY M. HOFFMAN, MD, FACC, …...Timothy M. Hoffman, MD, FACC, FAHA October 2018 Curriculum Vitae 5 12. Hoffman TM, Welty S. Physiology of the pre-term and term

CURRICULUM VITAE

TIMOTHY M. HOFFMAN, MD, FACC, FAHA Education Postgraduate Education:

1988-92 MD West Virginia University School of Medicine 1984-88 BS Allegheny College (Biology)

Postgraduate Training and Fellowship Appointments:

1999-00 Cardiac Critical Care and Thoracic Organ Transplantation Fellowship, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA

1996-99 Cardiology Fellowship, Children’s Hospital of Philadelphia, University of

Pennsylvania School of Medicine, Philadelphia, PA 1995-96 Chief Resident, Pediatrics, West Virginia University Children’s Hospital,

Morgantown, WV 1992-95 Pediatric Residency, West Virginia University Children’s Hospital, WVU

School of Medicine, Morgantown, WV

Specialty Certifications:

2013 American Board of Pediatrics Recertification 2007 American Board of Pediatric Cardiology Recertification 2002 American Board of Pediatrics Recertification 2000 American Board of Pediatric Cardiology (1518) 1995 American Board of Pediatrics (056172) 1993 National Board of Medical Examiners

Professional Experience –Employment History

09/16-present Governors Club Distinguished Professor in Pediatric Cardiology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina Children’s Hospital

Timothy M. Hoffman, MD, FACC, FAHA October 2018 Curriculum Vitae

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03/15-present Division Chief, Pediatric Cardiology, Professor, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina Children’s Hospital

11/13-2/15 Professor, Department of Pediatrics, Division of Cardiology, Nationwide

Children’s Hospital, The Ohio State University College of Medicine 07/10-2/15 Associate Medical Director of Cardiology, Nationwide Children’s

Hospital, The Ohio State University College of Medicine 04/09-2/15 Cardiology Fellowship Director, Nationwide Children’s Hospital, The

Ohio State University College of Medicine 01/02-1/15 Medical Director, Heart Transplant and Heart Failure Program,

Nationwide Children’s Hospital, The Ohio State University College of Medicine

11/06-10/13 Associate Professor of Pediatrics, Department of Pediatrics, Division of Cardiology, Nationwide Children’s Hospital, The Ohio State University College of Medicine

01/02-10/06 Assistant Professor of Pediatrics, Department of Pediatrics, Division of

Cardiology, Nationwide Children’s Hospital, The Ohio State University College of Medicine; Section of Cardiac Critical Care and Heart Transplant Services

01/01-12/01 Interim Section Chief and Medical Director of the Thoracic Organ Transplantation Program, Department of Pediatrics, Division of Cardiology, The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine

07/00-12/01 Assistant Professor, Department of Pediatrics, Division of Cardiology,

The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine; Sections of Cardiac Critical Care and Thoracic Organ Transplantation

07/96-6/00 Instructor, General Pediatrics (Pediatric Cardiology Fellow), The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine

07/95-06/96 Instructor, General Pediatrics, West Virginia University Children’s Hospital, West Virginia University School of Medicine

Licensure:

2015-present North Carolina (2015-00309) 2002-18 Ohio (#35-08-0682-H)


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1996-10 Pennsylvania (MD-057980-L) 1994-96 West Virginia (#17874)

Honors

2003-18 Best Doctors in America 2017 Castle Connolly Top Doctor 2014 Pediatric Cardiac Intensive Care Society Presidential Distinguished

Service Award 2011 North Hills High School Distinguished Alumni Award 2006 Gold Citation Award, Allegheny College 2000 Keynote Commencement Speaker, North Hills High School (Alma Mater),

Pittsburgh, PA 1999-00 Aaron Morton Endowed Fellowship, Children’s Hospital of Philadelphia,

University of Pennsylvania School of Medicine 1997 Ann Newman Fellowship, Outstanding Clinical Cardiology Fellow,

Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine

1996 Outstanding Resident Research Award, Department of Pediatrics, WVU School of Medicine

1995 Outstanding Resident Teaching Award, Department of Pediatrics, WVU School of Medicine

1994 Outstanding Resident in Ambulatory Medicine, Department of Pediatrics, WVU School of Medicine

1993 Outstanding Intern, Department of Pediatrics, WVU School of Medicine 1992 Edward G. Stuart Memorial Award, WVU School of Medicine 1992 Alpha Omega Alpha 1991 E.B. Flink Award for Excellence, Department of Internal Medicine, WVU

School of Medicine 1988 Phi Beta Kappa 1987 National Dean’s List 1987 Who’s Who Among American Colleges and Universities

Bibliography and Products of Scholarship Books and Chapters:

1. Hoffman TM. Phosphodiesterase Inhibitors. Heart Failure in the Child and Young Adult: From Bench to Bedside, edited by Jeffries JL, Chang AC, Rossano JW, Shaddy RE, and Towbin JA. Elsevier Inc, London 2018; 517-522.


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2. Hoffman TM, Welty S. Physiology of the pre-term and term infant. Moss and Adams’

Heart Disease in Infants, Children, and Adolescents, 9th edition, edited by Allen HD, Shaddy RE, Penny DJ, Feltes TF, and Cetta F. Wolters Kluwer, Philadelphia 2016; 655-664.

3. Thrush PT, Mendell JR, Flanigan KM, Hoffman TM, Allen HD. The heart in muscular

dystrophies. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 9th edition, edited by Allen HD, Shaddy RE, Penny DJ, Feltes TF, and Cetta F. Wolters Kluwer, Philadelphia 2016; 1343-1354.

4. Contributing author. Chapter 11: Acute heart failure. ISHLT Monograph Series Vol. 8: ISHLT Guidelines for the Management of Pediatric Heart Failure, edited by Kirk R, Dipchand AI, Rosenthal DN, and Kirklin JK. UAB Printing, Birmingham 2014; 201-229.

5. Allen HD, Mendell JR, Flanigan KM, Hoffman TM. The heart in muscular dystrophies. In Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 8th edition, edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia 2013; 1277-1286.

6. Hoffman TM, Welty S. Physiology of the pre-term and term infant. In Moss and

Adams’ Heart Disease in Infants, Children, and Adolescents, 8th edition, edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia 2013; 473-482.

7. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 5e,

Schwartz and Zorc, Williams and Wilkins, Philadelphia, PA 2013; 883-899. 8. Tsai SF, Stines JR, Hoffman TM. Syncope. In Child Neurology Manual, 1e, Weisleder,

World Scientific Publishing Co. Pte. Ltd, Singapore 2012; 163-174.

9. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 4e, Schwartz and Zorc, Williams and Wilkins, Philadelphia, PA 2009; 959-974.

10. Allen HD, Hoffman TM Mendell JR. The heart in muscular dystrophies. In Moss and

Adams’ Heart Disease in Infants, Children, and Adolescents, 7th edition edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia 2008; 1234-1241.

11. Olson TM, Hoffman TM, Chan DP. Dilated cardiomyopathy. In Moss and Adams’

Heart Disease in Infants, Children, and Adolescents, 7th edition edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia 2008; 1195-1206.


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12. Hoffman TM, Welty S. Physiology of the pre-term and term infant. In Moss and Adams’ Heart Disease in Infants, Children, and Adolescents, 7th edition edited by Allen HD, Driscoll DJ, Shaddy RE, and Feltes TF. Lippincott Williams and Wilkins, Philadelphia 2008; 440-447.

13. Luce WA, Joshi MS, Hoffman TM, Feltes TF, Bauer JA. Immune mechanisms in

pediatric cardiovascular disease. In Immune Dysfunction and Immunotherapy in Heart Disease, edited by Ronald R. Watson and Douglas F. Larson, Chapter 2, 2007; 6-16.

14. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 3e

Schwartz, Williams and Wilkins, Philadelphia, PA 2003; 920-924.

15. Hoffman TM, Spray TL. Infant Heart Transplantation. In Hypoplastic Left Heart Syndrome, Rychik J and Wernovsky G (eds), Kluwer Academic Publishers, Norwell, MA 2003; 241-250.

16. Hoffman TM. The Cardiology laboratory. In The 5 minute Pediatric Consult, 3e

Schwartz, Williams and Wilkins, Philadelphia, PA 2003; 899-906.

17. Hoffman TM. Cardiomyopathy. In The 5 minute Pediatric Consult, 3e Schwartz, Williams and Wilkins, Philadelphia, PA 2003; 216-217.

18. Hoffman TM. Rheumatic fever. In The 5 minute Pediatric Consult, 3e Schwartz,

Williams and Wilkins, Philadelphia, PA 2003; 716-717.

19. Hoffman TM, Spray TL. Transplantation for Hypoplastic Left Heart Syndrome. In Hypoplastic Left Heart Syndrome, Hennein HA and Bove EL (eds), Chapter 18, Futura Publishing, Armonk, NY 2002; 289-300.

20. Hoffman TM. The Cardiology laboratory. In The 5 minute Pediatric Consult, 2e

Schwartz, Williams and Wilkins, Philadelphia, PA 2000; 891-897. 21. Hoffman TM. Cardiomyopathy. In The 5 minute Pediatric Consult, 2e Schwartz,

Williams and Wilkins, Philadelphia, PA 2000; 222-223.

22. Hoffman TM. Rheumatic fever. In The 5 minute Pediatric Consult, 2e Schwartz, Williams and Wilkins, Philadelphia, PA 2000; 710-711.

23. Hoffman TM. The Cardiology laboratory. In Clinical Handbook of Pediatrics, 2e

Schwartz, Williams and Wilkins, Philadelphia, PA 1998; 892-899. Books and Chapters (In Press/Submitted):

1. Phelps C, Simic S, Hoffman TM. Low Cardiac Output Syndrome. Second Edition of

Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care edited by da Cruz EM, Ivy, D, and Jaggers J. Springer (submitted July 2018).


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Refereed Papers/Articles:

1. Rostad CA, Wehrheim K, Kirklin JK, Naftel D, Pruittt E, Hoffman TM, L’Ecuyer T, Berkowitz K, Mahle WT, Scheel JN. Bacterial Infections in Pediatric Heart Transplant Recipients: Epidemiology, Risk Factors, and Outcomes J Heart Lung Transplant 2017 Sep; 36(9):996-1003.

2. Peura JL, Colvin-Adams M, Francis GS, Grady KL, Hoffman TM, Jessup M, Ranjit J, Kiernan MS, Mitchell JE, O’Connell JB, Pagani FD, Petty M, Ravichandran P, Rogers JG, Semigran MJ, Toole MJ. Recommendations for the Use of Mechanical Circulatory Support: Ambulatory and Community Patient Care: A Consensus Statement from the American Heart Association. Circulation, 2017 Jun; 20;135(25):e1145-e1158.

3. Marino BS, Goldberg DJ, Dorfman AL, King E, Kalkward H, Zemel BS, Smith M, Pratt

J, Fogel MA, Shillingford AJ, Deal BJ, John AS, Goldberg CS, Hoffman TM, Jacobs ML, Lisec A, Finan S, Kochilas LK, Pawlowski TW, Campbell K, Joiner C, Goldstein S, Stephens P, Chin AJ. Abnormalities in serum biomarkers correlate with lower cardiac index in the Fontan population. Cardiol Young 2017 Jan;27(1):59-68.

4. Thrush, PT, Pahl E, Naftel DC, Pruitt E, Everitt MD, Missler H, Zangwill SD, Burch M, Hoffman TM, Butts RJ, Mahle WT. A Multi-institutional Evaluation of Antibody-Mediated Rejection Utilizing the PHTS Database: Incidence, Therapies, and Outcomes J Heart Lung Transplant 2016 Dec;35(12):1497-1504.

5. Mills KI, Vincent JA, Zuckerman WA, Hoffman TM, Canter CE, Marshall AC, Blume ED, Bergersen L, Daly KP. "Is endomyocardial biopsy a safe and useful procedure in children with suspected cardiomyopathy?" Pediatr Cardiol 2016 Oct;37(7):1200-10.

6. Hoffman TM. Chronic Heart Failure. Pediatr Crit Care Med 2016 Aug:17 (8 Suppl 1):S119-S123.

7. Hoffman TM. Quality Improvement in Pediatric Heart Failure. Progress in Pediatric

Cardiology Mar 2016 40:9-11.

8. Rossano JW, Hoffman TM, Jefferies JL, Lorts A, Kirsch RE, Thiagarajan RR. Clinical issues and controversies in heart failure and transplantation. World J Pediatr Congenit Heart Surg 2016 Jan;7(1):63-71.

9. Backes CH, Huang H, Cua CL, Garg V, Smith CV, Yin H, Galantowicz M, Bauer JA, Hoffman TM. Early versus Delayed Umbilical Cord Clamping in Infants with Congenital Heart Disease: A Pilot, Randomized, Controlled Trial. J Perinatol 2015 Oct;35(10):826-31.

10. Rossano JW, Dipchand AI, Hoffman TM, Singh TP, Jefferies JL. Advances in pediatric heart failure and treatments. Progress in Pediatric Cardiology July 2015, 39(1):33–36.


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11. Schumacher K, Almond C, Singh TP, Kirk R, Spicer R, Hoffman TM, Hsu D, Naftel DC, Pruitt E, Zamberlan M, Canter CE, Gajarski RJ. Predicting Graft Loss by 1-Year in Pediatric Heart Transplant Candidates: An Analysis of the PHTS Database. Circulation 2015 Mar 10;131(10):890-8.

12. Naguib AN, Winch PD, Tobias JD, Yeates KO, Miao Y, Galantowicz M, and Hoffman TM. Neurodevelopmental outcome after cardiac surgery utilizing cardiopulmonary bypass in children. Saudi J Anaesth. 2015 Jan;9(1):12-8.

13. Thrush PT, Hoffman TM. Pediatric heart transplantation – Indications and outcomes in

the current era. J Thorac Dis 2014 Aug;6(8):1080-96.

14. Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, Hoffman TM, Kiernan MS, Lerakis S, Piga A, Porter JB, Walker JM, Wood J. Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement from the American Heart Association. Circulation 2013 Jul 16;128(3):281-308.

15. Naguib AN, Tobias JD, Hall MW, Cismowski MJ, Miao Y, Barry N, Preston T, Galantowicz M, Hoffman TM. The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: A prospective, double-blinded, and randomized study. Pediatr Crit Care Med. 2013 Jun;14(5):481-90.

16. Hayes D, Baker PB, Preston TJ, Kirkby S, Galantowicz M, Hoffman TM. Aggressive coronary artery vasculopathy after combined heart-lung transplantation. Congenit Heart Dis 2013 May-Jun;8(3):E88-91.

17. Hayes D, Galantowicz M, Hoffman TM. Combined heart-lung transplantation: A perspective on the past and future. Pediatr Cardiol 2013 Feb;34(2):207-12.

18. Allen HD, Thrush PT, Hoffman TM, Flanigan KM, Mendell JR. Cardiac management in neuromuscular diseases. Phys Med Rehabil Clin N Am 2012 Nov;23(4):855-68.

19. Peura JL, Colvin-Adams M, Francis GS, Grady KL, Hoffman TM, Jessup M, Ranjit J, Kierman MS, Mitchell JE, O’Connell JB, Pagani FD, Petty M, Ravichandran P, Rogers JG, Semigran JM, and Toole JM. Recommendations for the Use of Mechanical Circulatory Support: Device Strategies and Patient Selection: A Scientific Statement from the American Heart Association. Circulation 2012 Nov 27;126(22):2648-2667.

20. Ameduri R, Zheng, Schectman, Hoffman TM, Gajarski R, Chinnock R, Fricker J, Naftel D, Kirklin, Dichand A, Canter C. Has Late Rejection Decreased in Pediatric Heart Transplantation in the Current Era? A Multi-institutional Study. J Heart Lung Transplant 2012 Sep;31(9):980-6.

21. Daly KP, Marshall AC, Vincent JA, Zuckerman WA, Hoffman TM, Canter C, Blume ED, Bergensen L. Endomyocardial biopsy is a safe and effective procedure in children: Results of a multi-center experience. J Heart Lung Transplant 2012 Apr;31(4):398-409.


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22. Feingold B, Zheng J, Law Y, Morrow WR, Hoffman TM, Schechtman KB, Dipchand

AI, Canter C. Risk factors for late renal dysfunction in pediatric heart transplantation: A multi-institutional study. Pediatr Transplantation 2011;15:699-705.

23. Hoffman TM. Impact of Evolution of the Fontan Operation on the Early and Late Mortality A Single Center Experience of 405 Patients over 3 Decades (Invited Commentary). Ann Thorac Surg 2011 Oct;92(4):1466-7.

24. Yates AR, Hoffman TM, Shepherd E, Boettner B, McBride K., Pediatric Sub-specialist controversies in the treatment of congenital heart disease in Trisomy 13 or 18. J Genet Couns 2011 Oct;20(5):495-509.

25. Hoffman TM. Newer inotropes in pediatric heart failure. J Cardiovasc Pharmacol 2011 Aug;58(2):121-5.

26. Yates AR, Hoffman TM, Hashiguchi B, Feltes TF, Cua CL. Initial counseling prior to palliation for hypoplastic left heart syndrome. Congenit Heart Dis 2011 Jul;6(4):347-58.

27. Hoffman TM. More than 30 years experience with surgical correction of

atrioventricular septal defects (Invited Commentary). Ann Thorac Surg 2010 Nov; 90(5):1561-2.

28. Jeffries JL, Hoffman TM, Nelson DP. Heart Failure Treatment in the Intensive Care Unit in Children. Heart Fail Clin 2010 Oct;6(4):531-58.

29. Kaltman JR, Andropoulos DB, Checchia PA, Gaynor JW, Hoffman TM, Laussen P, Ohye R, Pearson G, Pigula F, Tweddell J, Wernovsky G, del Nido P. Report of the Pediatric Heart Network and National Heart, Lung, and Blood Institute Working Group on the Perioperative management of congenital heart disease. Circulation 2010;121(25);2766-2772.

30. Fitzgerald-Butt SM, Byrne L, Gerhardt CA, Vannatta K, Hoffman TM, McBride KL. Parental knowledge and attitudes toward hypertrophic cardiomyopathy genetic testing. Pediatr Cardiol 2010 Feb;31(2):195-202.

31. Kirk R, Naftel D, Hoffman TM, Almond C, Boyle G, Caldwell RL, Kirklin JK, White K, Dipchand AI. Outcome of pediatric patients with dilated cardiomyopathy listed for transplant: A Multi-Institutional study. J Heart Lung Transplant 2009 Dec;28(12):1322-8.

32. Moiduddin N, Cheatham JP, Hoffman TM, Phillips A, Kovalchin JP. Amplatzer septal occluder associated with late pulmonary venous obstruction and aorta to left atrial fistula. Am J Cardiol 2009;103:1039-1040.


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33. Dyke PC 2nd, Konczal L, Bartholomew D, McBride KL, Hoffman TM. Acute dilated cardiomyopathy in a patient with deficiency of long-chain 3-hydroxyacyl-CoA dehydrogenase. Pediatr Cardiol 2009 May; 30(4):523-6.

34. Hoffman TM. Risks and predictors of blood transfusion in pediatric patients undergoing open heart surgery (Invited Commentary). Ann Thorac Surg 2009 Jan;87(1):197.

35. Galantowicz M, Cheatham JP, Phillips A, Cua CL, Hoffman TM, Hill SL, Rodeman R. The hybrid approach for hypoplastic left heart syndrome intermediate results after the learning curve. Ann Thorac Surg 2008 Jun;85(6):2063-71.

36. Garg R, Raman SV, Hoffman TM, Hayes J, Daniels CJ. Serum markers of systemic right ventricular function and exercise performance. Pediatr Cardiol 2008 May;29(3):641-648.

37. Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. Necrotizing

enterocolitis in neonates with congenital heart disease. Life Sci 2008; 82(7-8):341-7.

38. Luce WA, Hoffman TM, Bauer JA. Bench to Bedside review: Developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatal versus adult sepsis. Critical Care 2007;11:228-237.

39. Astor TL, Galantowicz M, Phillips A, Davis JT, Hoffman TM. Domino heart transplantation involving infants. Am J Transplant 2007;7:2626-29.

40. Cua CL, Galantowitz ME, Turner DR, Forbes TJ, Hill SL, Hoffman TM, Cheatham JP. Palliation via hybrid procedure of 1.4 kg patient with a hypoplastic left heart. Congenital Heart Disease 2007;2:191-193.

41. Hoffman TM, Taeed R, Niles JP, McMillin MA, Perkins LA, Feltes TF. Parental factors impacting the enrollment of children in cardiac critical care clinical trials. Pediatr Cardiol 2007;8(3):167-171.

42. Dyke PC 2nd, Yates AR, Cua CL, Hoffman TM, Hayes J, Feltes TF, Springer MA, Taeed R. Increased calcium supplementation is associated with morbidity and mortality in the infant postoperative cardiac patient. Pediatric Critical Care Medicine 2007;8(3):254-7.

43. Yates AR, Dyke PC, Taeed R, Hoffman TM, Hayes J, Feltes TF, Cua CL. Hyperglycemia is a marker for poor outcome in the post-operative pediatric cardiac patient. Pediatric Critical Care Medicine 2006;7:351-55.

44. Zuppa AF, Nicolson SC, Adamson PC, Wernovsky G, Mondick J, Burnham N, Hoffman TM, Gaynor JW, Davis LA, Greeley WJ, Spray TL, Barrett J. The impact of cardiopulmonary bypass and modified ultrafiltration on the plasma population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing Stage 1 reconstruction. Anesth Analg 2006;102(4):1062-9.


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45. Cua CL, Thiagarajan RR, Taeed R, Hoffman TM, Lai L, Hayes J, Laussen PC, Feltes,

TF. Improved inter-stage mortality with the modified Norwood procedure, a meta-analysis. Annals of Thoracic Surgery 2005;80(1):44-49.

46. Cua CL, Hoffman TM, Taeed R, Weinstein S, Gomez D, Olshove VF, Craenen J. Cerebral saturations trend with mixed venous saturations in patients undergoing extracorporeal life support. Perfusion 2004;19:171-176.

47. Morris MC, Ittenbach RF, Godinez RI, Portnoy JD, Tabbutt S, Hanna BD, Hoffman TM, Gaynor JW, Connelly JT, Helfaer MA, Spray TL, Wernovsky G. Risk factors for mortality in 137 pediatric cardiac intensive care unit patients managed with ECMO. Crit Care Med 2004 Apr;32(4):1061-1069.

48. Bailey JM, Hoffman TM, Wessel DL, Nelson DP, Atz AM, Chang AC, Kulik T, Spray

TL, Akbary A, Miller RP, Wernovsky G. A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery. Journal of Pharmacokinetics and Pharmacodynamics 2004 Feb;31(1):43-59.

49. Hoffman TM, Wernovsky G, Atz AM, Kulik TJ, Nelson DP, Chang AC, Bailey JM,

Akbary A, Kocsis JF, Kaczmerak R, Spray TL, Wessel DL. The efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 2003;107:996-1002.

50. Hoffman TM, Bush DM, Wernovsky G, Wieand TS, Cohen MI, Gaynor JW, Spray TL, Rhodes LA. Postoperative junctional ectopic tachycardia in children: Incidence, risk factors, and treatment. Annals of Thoracic Surgery 2002;74(5):1607-1611.

51. Hoffman TM, Wernovsky G, Wieand TS, Cohen MI, Jennings AC, Vetter VL, Godinez RI, Gaynor JW, Spray TL, Rhodes LA. The incidence of arrhythmias in a pediatric cardiac intensive care unit. Pediatric Cardiology Nov/Dec 2002;23(6):598-604.

52. Fleenor JT, Hoffman TM, Bush DM, Paridon SM, Clark BJ, Spray TL, Bridges ND. Pneumatosis intestinalis after pediatric thoracic organ transplant. Pediatrics 2002;109(5):e78-80.

53. Hoffman TM, Wernovsky G, Atz AM, Bailey JM, Akbary A, Nelson DP, Chang AC, Kulik TJ, Spray TL, Wessel DL. Trial Designs: Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP study). Am Heart J 2002;143(1):15-21.

54. Hoffman TM, Rhodes LA, Wieand TS, Spray TL, Bridges ND. Arrhythmias after

pediatric lung transplantation. Pediatric Transplantation 2001;5(5):349-52.

55. Hoffman TM, Gaynor JW, Bridges ND, Paridon S, Spray TL. Aortic homograft


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interposition for management of complete tracheal anastomotic disruption after heart- lung transplantation. J Thorac Cardiovasc Surg 2001;121(3):587-588.

56. Bush DM, Hoffman TM, Del Rosario JD, Eiriksson H, Rome JJ. Frequency of

restenosis after balloon pulmonary arterioplasty and its causes. Am J Cardiol 2000; 86(11):1205-1209.

57. Cohen MI, Bridges ND, Gaynor JW, Hoffman TM, Wernovsky G, Vetter VL, Spray TL, Rhodes LA. Modifications to the cavopulmonary anastomosis do not eliminate sinus node dysfunction. J Thorac Cardiovasc Surg 2000; 120(5):891-901.

58. Hoffman TM, Spray TL, Gaynor JW, Clark BJ, Bridges ND. Survival after acute graft

failure in pediatric thoracic organ transplant recipients. Pediatric Transplantation 2000; 4(2):112-17.

59. Hoffman TM, Rhodes LA, Pyles LA, Balian AA, Neal WA, Einzig S. Childhood acute rheumatic fever: A comparison of recent resurgence areas to cases in West Virginia. West Virginia Medical Journal 1997; 93:260-63.

Refereed Papers/Articles (In Press/Submitted):

1. Hollander SA, Pruitt E, Sutherland SM, Cantor RS, Kirklinj J, Ravekes WJ, Ameduri R, Chrisant M, Hoffman TM, Lytriyi I, Conway J. Renal Injury and Recovery in Pediatric Patients After Ventricular Assist Device Implantation and Cardiac Transplant. (To be resubmitted November 2018).

2. Smith CL, Boucek D, DeWitt A, Ravishankar C, Pinto E, Hoffman TM, Dori Y, Rome JJ. Decompression of the Thoracic Duct: A Novel Transcatheter Approach in a Patient with an LSVC to Atretic Coronary Sinus. (Submitted October 2018).

3. Hayes, D Jr., Wilson KC, Krivchenia K, Hawkins SM, Balfour-Lynn IM, Gozal D, Panitch HB, Splaingard ML, Rhein LM, Kurland G, Abman SH, Hoffman TM, Carroll CL, Cataletto ME, Tumin D, Oren E, Martin RJ, Baker J, Porta GR, Kaley D, Gettys A; Deterding R, MD on behalf of the American Thoracic Society Assembly on Pediatrics. Home Oxygen Therapy for Children: An Official ATS Clinical Practice Guideline (Submitted October 2018).

Abstracts:

1. Watkins SE, Kemper AR, D’Ottavio A, Wiedemeier M, Meyer R, Greene N, Hoffman TM, Sang C, Paolillo J, Walsh M, Li JS. Third-grade Academic Performance and Episodes of Care among Children with Congenital Heart Defects (To be presented at the 2018 American Heart Association Scientific Session, Chicago, November 2018).

2. Goldstein, SA, D’Ottavio A, Spears T, Chiswell K, Weidemeyer M, Spates T, Krasuski

RA, Kemper AR, Meyer RE, Hoffman TM, Walsh MJ, Sang CJ, Paolillo J, and Li JS.


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Causes of Death in Adults with Congenital Heart Disease Differ by Lesion Severity (To be presented at the 2018 American Heart Association Scientific Session, Chicago, November 2018).

3. Hollander SA, Pruitt E, Sutherland SM, Cantor RS, Kirklinj J, Ravekes WJ, Ameduri R, Chrisant M, Hoffman TM, Lytriyi I, Conway J. Failure to Improve Renal Function Following VAD Placement Predicts Renal Injury and Chronic Kidney Disease Following Cardiac Transplant. (Presented at the ISHLT 38th Annual Scientific Meeting, Nice, April 2018 and the STS-INTERMACS Meeting, May 2018).

4. Arbon KS, Law YM, Kirklin JK, Pruitt E, Showengerdt KO, Hoffman TM, L’Ecuyer TJ, Kindel SJ. Surveillance invasive hemodynamics in pediatric heart transplant patiens: Utility or Futility? (Presented at the 2017 American Heart Association Scientific Session, Anaheim, November 2017).

5. Shamszad P, Almond CS, Hoffman TM, Rossano JW. Variability in Perioperative Inotropic Use in Congenital Cardiac Surgery. (Presented at the 7th World Congress of Pediatric Cardiology and Cardiothoracic Surgery, Barcelona, July 2017).

6. Rostad CA, Wehrheim K, Berkowitz K, Hoffman TM, L’Ecuyer T, Mahle WT, Pruittt E, Kirklin J, Scheeel JN. Bacterial Infections in Pediatric Heart Transplant Recipients: Epidemiology, Risk Factors, and Outcomes. (Presented at the ISHLT 36th Annual Scientific Meeting, Washington DC, April 2016).

7. Thrush, PT, Pahl E, Naftel DC, Pruitt E, Everitt MD, Missler H, Zangwill SD, Burch M, Hoffman TM, Butts RJ, Mahle WT. A Multi-institutional Evaluation of Antibody-Mediated Rejection Utilizing the PHTS Database: Incidence, Therapies, and Outcomes. (Presented at the ISHLT 35th Annual Scientific Meeting, Nice, April 2015).

8. Mills KI, Vincent JA, Zuckerman WA, Hoffman TM, Canter CE, Marshall AC, Blume ED, Bergensen LJ, Daly KP. Is Endomyocardial Biopsy a Safe and Useful Procedure in Children with Suspected Cardiomyopathy? (Presented at the American Academy of Pediatrics National Conference 2014, San Diego, October 2014).

9. Yates AR, Preston TJ, Duffy VL, Hayes D, Hoffman TM, Simsic J, McConnell PI.

Assessment of cardiac function on VA-ECMO support using dynamic flow manipulation. (Presented at the 30th Annual Children's National Medical Center Symposium on ECMO & Advanced Therapies for Respiratory Failure, Keystone, Feb 2014).

10. Backes C, Huang H, Bauer JA, Galantowicz M, Hoffman TM. Delayed Umbilical Cord

Clamping Among Infants With Congenital Heart Disease: A Randomized, Multi-center, Controlled Trial. (Presented at the American Heart Association Scientific Sessions 2013, Dallas, November 2013).

11. Naguib AN, Tobias JD, Yeates K, Bissonette B, Yongjie M, Galantowicz M, Hoffman

TM. Neurodevelopmental Outcomes After Pediatric Cardiac Surgery: A Follow-Up of a


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Prospective Randomized and Blinded Study. (Presented at the American Society of Anesthesia Meeting 2013, San Francisco, October 2013).

12. Naguib AN, Tobias JD, Yeates K, Miao Y, N’Diris B, Galantowicz M, Hoffman TM.

The Role of Different Anesthetic Techniques on the Neurodevelopmental Outcomes after Pediatric Cardiac Surgery: A Follow-up of a Prospective Randomized and Blinded study. (Presented at Society of Pediatric Anesthesia Meeting 2013, Las Vegas, March 2013).

13. Naguib AN, Tobias JD, Hall MW, Cismowski MJ, Miao Y, Barry D, Preston T, Galantowicz M, Hoffman TM. The effect of perioperative high does dexamethasone on the systemic inflammatory response and outcomes after pediatric cardiac surgery. (Presented at Anesthesiology 2012, Washington DC, October 2012).

14. Schumacher K, Kirk R, Almond C, Singh TP, Spicer R, Hoffman TM, Hsu D, Naftel D,

Tresler M, Zamberlan M, Canter C, Gajarski R. Predicting 1-year survival in pediatric heart transplant candidates with cardiomyopathy: An analysis of the PHTS database. (Presented at the ISHLT 32nd annual meeting, Prague, April 2012).

15. Schumacher K, Kirk R, Almond C, Singh TP, Spicer R, Hoffman TM, Hsu D, Naftel D,

Tresler M, Zamberlan M, Canter C, Gajarski R. Predicting 1-year survival in pediatric heart transplant candidates with congenital heart disease: An analysis of the PHTS database. (Presented at the ISHLT 32nd Annual Meeting, Prague, April 2012).

16. Naguib AN, Tobias JT, Hall MW, Cismowski MJ, Miao Y, Barry D, Preston T,

Galantowicz M, Hoffman TM. The role of different anesthetic techniques in altering the stress response during cardiac surgery in children in the setting of early tracheal extubation: A prospective randomized study. (Presented at the Congenital Cardiac Anesthesia Society Meeting (Society of Pediatric Anesthesia), Tampa, February 2012).

17. Lee A, McKee C, Biddle A, Harrison S, Hoffman TM, Marcum G, Teske D, Brilli RJ.

A Preventable Harm Index is an effective tool to measure patient safety events in a pediatric cardiothoracic intensive care unit. (Presented at the 41st Annual Critical Care Congress of the Society of Critical Care Medicine, Houston, February 2012).

18. Daly KP, Marshall AC, Vincent JA, Zuckerman WA, Hoffman TM, Canter C, Blume

ED, Bergensen L. Endomyocardial biopsy is a safe and effective procedure in children: Results of a multi-center experience. (Presented at the American College of Cardiology Scientific Meeting 2011, New Orleans, April 2011).

19. Marino BS, Goldberg D, Dorfman AL, Kalkwarf H, Zemel B, Smith M, Pratt J, King E, Fogel M, Shillingford AJ, Deal B, Anitha JS, Goldberg C, Hoffman TM, Jacobs M, LIsec A, Finan B, Kochilas L, Pawlowski T, Campbell K, Clinton J, Goldstein S, Stephens P, Chin A. Serum Biomarkers Correlate with Lower Cardiac Index in the Fontan Population . (Presented at the American College of Cardiology Scientific Meeting 2011, New Orleans, April 2011).


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20. Ameduri R, Zheng, Schectman, Hoffman TM. Gajarski R, Chinnock R, Fricker J, Naftel D, Kirklin, Dichand A, Canter C. Has Late Rejection Decreased in Pediatric Heart Transplantation in the Current Era? A Multi-institutional Study. (Presented at the American Heart Association Scientific Session 2010, Chicago, November 2010).

21. Feingold B, Zheng J, Law Y, Morrow R, Hoffman TM, Schectman KB, Canter C. Risk

factors for renal dysfunction in pediatric heart transplantation: A multi-institutional study. (Presented at the ISHLT 2010 meeting, Chicago, April 2010).

22. Yates AR, Hoffman TM, Hashiguchi B, Feltes TF, Cua CL. Initial counseling prior to

palliation for hypoplastic left heart syndrome. (Presented at the Pediatric Cardiac Intensive Care Society Meeting, Miami, December 2008).

23. Moiduddin N, Cheatham JP, Hoffman TM, Phillips A, Kovalchin JP. Amplatzer septal

occluder associated with late pulmonary venous obstruction and aorta to left atrial fistula. (Presented at the Ohio ACC 18th Annual Meeting, Columbus, October 2008).

24. Feingold, B, Schechtman KB, Law YM, Spicer RL, Hoffman TM, Darragh RK, Asante-

Korang A, Finney H, Zheng J, Hmiel P, Canter CE. Serum creatinine is a limited indicator of renal function in pediatric heart transplantation. (Presented at the ISHLT 2008 meeting, Boston, April 2008).

25. Kirk R, Naftel D, Hoffman TM, Almond C, Boyle G, Calswell RL, Kirklin JK, Flett J,

Dipchand AI. Dilated cardiomyopathy and listing for heart transplantation: A multi-institutional study. (Presented at the ISHLT 2008 meeting, Boston, April 2008).

26. Marquardt DJ, Yates AR, Frazier WJ, Muszynski JA, Hoffman TM, Hall MW. Increased

pulsatility of thyroid stimulating hormone release is associated with immunodepression acutely after pediatric cardiopulmonary bypass. (Presented at the Society of Critical Care Congress 37th Annual Metting, Honolulu, Feb 2008).

27. Yates AR, McBride KL, Joshi MS, Nicholson L, Bauer JA, Hoffman TM. Palliation of

congenital heart disease in children with Trisomy 13 or Trisomy 18 is driven by physician experience and parental expectation. (Presented at the Society of Critical Care Congress 37th Annual Metting, Honolulu, Feb 2008).

28. Hoffman TM, Wessel DL, Chang AC, Kulik TL, Atz AM, Nelson DP, Spray TL, Cook AC, Bauer JA, Wernovsky G. Milrinone usage in the neonate following congenital cardiac surgery: Experience from the PRIMACORP trial. (Presented at the Pediatric Academic Society Annual Meeting, Toronto, May 2007).

29. Marquardt DJ, Frazier WJ, Hall MW, Yates AR, Hoffman TM, Muszynski JA. Anterior

pituitary function acutely following cardiopulmonary bypass in children. (Presented at the 36th Critical Care Congress, Orlando, February 2007 and Pediatric Academic Society Annual Meeting, Toronto, May 2007).


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30. Galantowitz ME, Cheatham JP, Feltes TF, Hoffman TM, Phillips A, Bauer J, Cook A, Rodeman R. The hybrid approach for the management of HLHS: Intermediate results after the learning curve. (Presented at the Society for Thoracic Surgeons 43rd Annual Meeting, San Diego, January 2007).

31. Santos A, Galantowicz ME, Feltes TF, Hoffman TM. The Hybrid Comprehensive Stage

2 Palliation: Peri-operative results. (Presented at the American Heart Association Scientific Session, Chicago, November 2006).

32. Dyke P, Yates AR, Cua CL, Hoffman TM, Hayes J, Feltes TF, Taeed R. High Calcium

Requirement Is Associated with Higher Morbidity and Mortality in the Infant Post-operative Cardiac Patient. (Presented at the Ohio Doctors Interested in Congenital Heart Disease (ODICH) 33rd Annual Meeting, Dayton, May 2005 and at the Ninth Annual Update on Pediatric Cardiovascular Disease, Scottsdale, February 2006).

33. Yates AR, Dyke PC, Taeed R, Hoffman TM, Hayes J, Feltes TF, Cua CL.

Hyperglycemia is a marker for poor outcome in the post-operative pediatric cardiac patient. (Presented at the Ohio Doctors Interested in Congenital Heart Disease (ODICH) 33rd Annual Meeting, Dayton, May 2005 and at the Annual Scientific Session of the Society of Crictical Care Medicine, San Francisco, January 2006).

34. Weinstein S, Hoffman TM, Munro HM, Malloy D, Kartha V, Galantowicz ME. Extubation in the operating room following congenital open heart surgery. (Presented at the World Congress of Pediatric Cardiology and Pediatric Cardiac Surgery, Buenos Aires, September 2005 and The American Academy of Pediatrics Annual Scientific Meeting, Washington DC, October 2005).

35. Hoffman TM, Taeed R, Niles JP, McMillin MA, Perkins LA, Feltes TF. Parental factors

impacting the enrollment of children in cardiac critical care clinical trials. Circulation supplement III 2004;110(17):442. (Presented at the American Heart Association Scientific Sessions, New Orleans, November 2004).

36. Malloy DA, Weinstein S, Munro H, Kartha VM, Galantowicz ME, Hoffman TM.

Extubation in the operating room after congenital heart surgery. (Presented at the Ohio Doctors Interested in Congenital Heart Disease (ODICH) 32nd Annual Meeting, Akron, April 2004).

37. Cua CL, Hoffman TM, Gomez D, Taeed R, Weinstein S, Craenen J. Correlation of

cerebral and mixed venous saturations in patients undergoing extracorporeal life support. (Presented at the American Academy of Pediatrics Annual National Meeting, New Orleans, LA, November 2003).

38. Zuppa AF, Nicolson SC, Wernovsky G, Spray TL, Gaynor JW, Moate P, Hoffman TM,

Burnham N, Adamson PC. The effects of cardiopulmonary bypass and modified ultrafiltration on the plasma pharmacokinetics of milrinone in neonates with HLHS.


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Critical Care Medicine 2002;20:A155. (Presented at the 32nd Critical Care Congress, San Antonio, January 2003).

39. Wallace W, Weinstein S, Hoffman TM, Vellucci S, Davis JT, Feltes TF. Use of

vasopressin to treat hypotension in pediatric patients after cardiac surgery. (Presented at the Ohio Doctors Interested in Congenital Heart Defects (ODICH) 30th Annual Meeting, Cleveland, June 2002).

40. Morris MC, Godinez RI, Spray TL, Hoffman TM, Wernovsky G. Extracorporeal

membrane oxygenation (ECMO) in 137 pediatric patients in a cardiac intensive care unit. Critical Care Medicine Supplement (Presented at the 31st Critical Care Congress, San Diego, January 2002).

41. Fleenor JT, Hoffman TM, Bush DM, Paridon SM, Clark BJ, Spray TL, Bridges ND.

Pneumotosis intestinalis after pediatric thoracic organ transplant. Pediatric Cardiology 2001:22(5):440-441. (Presented at the American Academy of Pediatrics National Meeting, San Francisco, October 2001).

42. Bush DM, Hoffman TM, Ro PS, Vetter VL, Rhodes LA. Influence of age and

underlying physiology on dispersion of depolarization and repolarization in infants. Cardiology in the Young 2001:11(Suppl 1):321-322. (Presented at the 3rd World Congress of Pediatric Cardiology and Cardiothoracic Surgery, Toronto, May 2001).

43. Hoffman TM, Bush DM, Wernovsky G, Wieand TS, Cohen MI, Rhodes LA.

Postoperative nonsustained ventricular tachycardia predicts poor outcome after cardiothoracic surgery in infants. Cardiology in the Young 2001:11(Suppl 1):308. (Presented at the 3rd World Congress of Pediatric Cardiology and Cardiothoracic Surgery, Toronto, May 2001).

44. Simsic J, Bush DM, Hoffman TM, Godinez RI, Gaynor JW, Wernovsky G, Tabbutt S.

Blood lactate measurements as one of several predictors of early outcome following neonatal complex congenital heart surgery. Cardiology in the Young 2001:11(Suppl 1):100. (Presented at the 3rd World Congress of Pediatric Cardiology and Cardiothoracic Surgery, Toronto, May 2001).

45. Hoffman TM, Bridges ND, Russo PA, Spray TL. Interstitial pneumonitis after lung or

heart-lung transplantation in very young recipients. J Heart Lung Transplant 2001;20(2):155. (Presented at the 21st Annual ISHLT Scientific Meeting, Vancouver, April 2001).

46. Hoffman TM, Rhodes LA, Wieand TS, Spray TL, Bridges ND. Arrhythmias after pediatric lung transplantation. Pediatric Transplantation 2000;4 Suppl. 2:47. (Presented at the First Meeting of the International Pediatric Transplant Association, Venice, August 2000).


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47. Cohen MI, Bridges ND, Gaynor JW, Hoffman TM, Wernovsky G, Vetter VL, Spray TL, Rhodes LA. Modifications to the cavopulmonary anastomosis do not eliminate sinus node dysfunction. (Presented at the American Association of Thoracic Surgery Scientific Session, Toronto, May 2000).

48. Hoffman TM, Wernovsky G, Wieand TS, Cohen MI, Vetter VL, Gaynor JW, Spray TL,

Rhodes LA. Predictors of arrhythmias in a pediatric cardiac intensive care unit. Journal of the American College of Cardiology Supplement A Feb 1999;33(2):539A. (Presented at the 48th Annual Scientific Session of the American College of Cardiology, New Orleans, March 1999 and at the 3rd International Symposium on Pediatric Cardiac Intensive Care, Miami, December 1999).

49. Bush DM, Hoffman TM, Del Rosario JD, Eiriksson H, Rome JJ. Restenosis after balloon pulmonary arterioplasty: Incidence and risk factors. Circulation Supp I 1999;100(18):I-321. (Presented at the American Heart Association 72nd Scientific Sessions, Atlanta, November 1999).

50. Hoffman TM, Wernovsky G, Wieand TS, Cohen MI, Vetter VL, Godinez RI, Gaynor

JW, Spray TL, Rhodes LA. Incidence and treatment of arrhythmia in a pediatric cardiac intensive care unit. Critical Care Medicine Supplement Jan 1999;27(1):A147. (Presented at the 28th Annual Scientific Session of the Society of Critical Care Medicine, San Francisco, January 1999).

51. Hoffman TM, Wernovsky G, Wieand TS, Cohen MI, Vetter VL, Jennings A, Gaynor

JW, Spray TL, Rhodes LA. Predictors of arrhythmia in a pediatric cardiac intensive care unit. (Presented at the Northeast Pediatric Cardiology Society Meeting, New York, 1998).


failure in pediatric thoracic organ transplant recipients. Pediatric Transplantation May 1998;2(Suppl 1):72. (Presented at the 3rd International Congress on Pediatric Transplantation, Boston 1998)


failure in pediatric thoracic organ transplant recipients. Transplantation Supplement (Presented at the 17th Annual Scientific Meeting of the American Society of Transplant Physicians, Chicago, 1998)

54. Hoffman TM, Rhodes LA, Pyles LA, Balian AA, Neal WA, Einzig S. Childhood acute

rheumatic fever: A comparison of recent resurgence areas to the West Virginia experience. (Presented at the Northeast Pediatric Cardiology Society Meeting, Philadelphia, 1997).


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Research Publications (non-peer reviewed):

1. Galantowicz M, Hoffman TM. Bloodless heart transplant surgery: A historic event for a 6 year old and Nationwide Children’s Hospital. Pediatric Directions Fall 2011; 6-10.

2. Hoffman TM, Phillips A. Shock waves: Treating cardiomyopathy. Pediatric Directions Spring 2011; 12-18.

3. Hoffman TM. The enrollment of children in cardiac critical care clinical trials. Invited

Editorial. Pediatric Health February 2008; 2(1)1-3.

4. Astor T, Davis JT, Galatowicz ME, Jadcherla SR, Phillips A, Hoffman TM. Domino heart transplant babies celebrate first birthdays. Pediatric Directions Winter 2006-07; 30:6-11.

5. Wernovsky G, Hoffman TM. Pediatric heart failure management: Solving the puzzle. Critical Care Med 2001; 29(10 Suppl):212-3.

Teaching Activities Major Teaching and Clinical Responsibilities:

1. Attending Cardiologist for Pediatric Heart Failure/Transplant Service

2. Attending Cardiologist for the Inpatient Cardiology Team 3. Attending Cardiologist: Outpatient Clinic (Heart Failure, Heart Transplant, and

General Pediatric Cardiac Care) 4. Fellow and Pediatric Resident Education

a) Formal and informal lectures b) Bedside teaching

Grand Rounds: UNC

08/15 UNC Children’s Hospital Grand Rounds, Chapel Hill, NC: Pediatric Heart Failure: An Art in Evolution.

Outside UNC

06/16 Betsy H. Cameron Women’s and Children’s Hospital, Wilmington, NC: Heart Failure Therapies in Pediatrics: Outpatient and Inpatient Perspectives.

06/15 WakeMed Pediatric Grand Rounds, Raleigh, NC: Heart Failure in Children: From Diagnosis to Transplant.


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05/15 Moses Cone Hospital Pediatric Grand Rounds, Greensboro, NC: Pediatric Heart Failure: An Art in Evolution.

04/15 Rex Pediatric Grand Rounds, Raleigh, NC: Pediatric Heart Failure: An Art in Evolution.

3/10 Dayton Children’s Medical Center Grand Rounds, Dayton, OH: Congestive Heart Failure.

2/09 Dayton Children’s Medical Center Grand Rounds, Dayton, OH: An Overview of

Pediatric Heart Transplantation. 7/07 Columbus Children’s Hospital Pediatric Grand Rounds, Columbus, OH: Heart

Failure in Children: From Diagnosis to Heart Transplantation. 3/06 Columbus Children’s Hospital Pediatric Grand Rounds, Columbus, OH: Clinical

Pathology Conference: Presentation of a Rare Systemic Disease with Congenital Diaphragmatic Hernia. Co-Presenter with Dr. Stephen Welty and Dr. Daniel Boue.

7/05 Columbus Children’s Hospital Pediatric Grand Rounds, Columbus, OH:

Congestive Heart Failure. 4/05 Columbus Children’s Hospital Transplantation Grand Rounds, Columbus, OH:

Heart Failure in Children: From Diagnosis to Heart Transplantation. 11/04 Genesis Health Care System, Bethesda Hospital Grand Rounds, Zanesville, OH:

Congenital Heart Disease: Anatomy and Physiology. 10/03 Southern Ohio Medical Center Grand Rounds, Portsmouth, OH: Congenital Heart

Disease in the Newborn. 2/01 South Jersey Medical Center Grand Rounds, Newcomb NJ: Congenital Heart

Disease: Anatomy and Physiology. 11/00 Children’s Hospital of Illinois Department of Pediatrics Grand Rounds, Peoria,

IL: HLHS: Transplantation vs. Staged Reconstruction. 4/00 West Virginia University Department of Pediatrics Grand Rounds, Morgantown,

WV: HLHS: Transplantation vs. Staged Reconstruction. 2/96 West Virginia University Department of Pediatrics Grand Rounds, Morgantown,

WV: Acute Rheumatic Fever.


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Continuing Medical Education Lectures: UNC

06/17 UNC Pediatric Neonatal and Critical Care Conference 2017, Chapel Hill, NC: Care of the Infant with Single Ventricle Physiology: Where are We Now?

Outside UNC 11/17 2017 American Heart Association Scientific Session, Anaheim, CA: Moderator:

Abstract Rapid Fire Oral: Heart Failure and Transplant. 09/17 50th Southeast Pediatric Cardiovascular Society Meeting, Atlanta, GA:

Pathophysiology of Acute Heart Failure and Treatment.

12/14 The Pediatric Cardiac Intensive Care Society 10th International Conference, Miami, FL: Acute Decompensated Heart Failure – Medical Management or Device?

11/14 American Heart Association Scientific Session 2014, Chicago, IL: Faculty

Mentor: CVDY Early Career Networking Session. 09/14 Pediatric Heart Failure Summit 2014, Cincinnati, OH: Postoperative Heart

Failure: It’s Not the Surgeon’s Fault. 05/14 3rd International Conference on Cardiomyopathy in Children, Bethesda, MD:

Quality Improvement in Pediatric Heart Failure. 01/14 Congenital Cardiology Group Retreat/Summit 2014, Innovation and Mentorship,

Laguna Beach, CA: Utilizing Quality Improvement Tools and Culture to Alter the Outcome: Single Ventricle Care.

10/13 Pediatric Heart Failure Summit 2013, Houston, TX: Moderator: Ethics and End

Stage Heart Failure. 12/12 The Pediatric Cardiac Intensive Care Society 9th International Conference,

Miami, FL: What would happen if I never used Lasix again? 11/12 2012 American Heart Association Scientific Session, Los Angeles, CA:

Moderator: Cardiovascular Seminar: Unusual Cardiomyopathies. 10/11 Nationwide Children’s Hospital Pediatric Grand Rounds, Columbus, OH: Clinical

and Pathologic Update of Pediatric Heart Transplantation. 2/11 Cardiology 2011, Scottsdale, Arizona: Transition from Fellowship to Career. 2/11 Cardiology 2011, Scottsdale, Arizona: Update on Post-Transplant

Lymphoproliferative Disease.


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2/11 Cardiology 2011, Scottsdale, Arizona: Inotropic Support: Hot New Stuff or Same Old-Same Old?

11/10 2010 American Heart Association Scientific Session, Chicago, IL: Newer

Inotropes in Pediatric Heart Failure: Application, Dosing, Results. 10/09 3rd Annual Solid Organ Transplantation for the Intensivist Conference,

Columbus, OH: Pediatric Heart Transplantation in the Medically High-Risk Patient.

2/09 Cardiology 2009, Nassau, Bahamas: Heart Transplantation in the Medically High-

Risk Patient. 2/09 Cardiology 2009, Nassau, Bahamas: Milrinone is Overrated and Overused? -or-

Can We Predict Who Will Develop Low Cardiac Output after Congenital Heart Surgery.

12/08 The Pediatric Cardiac Intensive Care Society 7th International Conference,

Miami, FL: Medical Management of Heart Failure in Patients With Single Ventricle Physiology.

6/08 Forty-fifth Annual Pediatrics for the Practitioner, San Antonio, TX: Sudden

Cardiac Death. 6/08 Forty-fifth Annual Pediatrics for the Practitioner, San Antonio, TX: Overview of

the Updated SBE Prophylaxis Guidelines. 6/08 Forty-fifth Annual Pediatrics for the Practitioner, San Antonio, TX: Evaluation of

Murmurs in Children. Auscultation Workshop. 4/08 International Society for Heart and Lung Transplantation 28th Annual Meeting

and Scientific Session, Boston, MA: Co-Chair Concurrent Session 45: Outcomes and Obstacles to Survival in Pediatric Heart Transplant.

1/08 Visiting Professor, Texas Children’s Hospital, Houston, TX: Cardiac Critical Care

Trials: Parent and Physician Perspective. 11/07 American Heart Association Scientific Session 2007, Orlando FL: Cardiovascular

Seminar: How Are They a Decade Later? Late Outcomes in Pediatric Heart Transplant Recipients. Lymphoproliferative Disorders/Malignancies.

12/06 Annual Emergency Medicine Conference 2006, Columbus, OH: Neonatal

Congenital Heart Disease: Basic Physiology. 3/06 Pediatric Pearls Conference 2006, Columbus, OH: Heart Transplant Care and

Surveillance.


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12/05 Pediatric Cardiac Intensive Care Symposium 2005, Miami, FL: Research in

Cardiac Critical Care and Parents. 2/05 Cardiology 2005, Eighth Annual Update on Pediatric Cardiovascular Disease,

Orlando, FL: Rheumatic Fever in 2005. 2/05 Cardiology 2005, Eighth Annual Update on Pediatric Cardiovascular Disease,

Orlando, FL: ICU Management of the Failing Heart. 10/04 West Virginia University Pediatric Oktoberfest, Morgantown, WV: Heart Failure

in Children: Diagnosis to Heart Transplantation. 12/03 Columbus Children’s Hospital Lounge and Learn Lecture Series, Columbus, OH:

Pediatric Heart Transplant Medicine. 5/03 Ohio Doctors Interested in Congenital Heart Disease (ODICH) 31st Annual

Meeting, Columbus, OH: Heart Failure in Children: Management of the Critically Ill Patient.

10/02 Columbus Children’s Hospital Lounge and Learn Lecture Series, Columbus, OH:

Postoperative Care after Pediatric Cardiothoracic Surgery. 4/02 The 22nd Annual Meeting and Scientific Sessions of the International Society of

Heart and Lung Transplantation, Washington, DC: Heart Failure in Children: Management of the Critically Ill Patient.

12/01 The 4th International Symposium on Pediatric Cardiac Intensive Care, Palm

Beach, FL: The PRIMACORP trial and results (Update on PRIMACORP Multicenter trial).

9/01 United Network for Organ Sharing Region 2 Clinical Forum, Philadelphia, PA:

Pediatric Lung Transplantation: Lobar and reduced-size transplantation. 5/01 Satellite Symposium 3rd World Congress of Pediatric Cardiology and

Cardiovascular Surgery, Toronto, ON: Pediatric Heart Failure Management: Solving the Puzzle. Co-Chairperson and Moderator

5/00 Columbus Children’s Hospital Cardiology Conference, Columbus, OH: Low

Cardiac Output after Cardiac Surgery in Children: PRIMACORP study premise and design.

4/99 Sixth Annual Stabilization of the Pediatric and Neonatal Patient for Transport, Philadelphia, PA: Rhythm Disturbances.


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Academic Committees:

2018- University of North Carolina School of Medicine Post Tenure Review Committee

2017-20 University of North Carolina School of Medicine Full Professors Appointment, Tenure, and Promotions Committee

2009-11 Nephrology Fellowship Scholarship Oversight Committee, Nationwide Children’s Hospital (Halima Janjua, MD)

2004-09 Cardiology and Critical Care Fellowship Scholarship Oversight Committee, Nationwide Children’s Hospital (Andrew Yates, MD)

2007-08 Critical Care Fellowship Scholarship Oversight Committee, Nationwide Children’s Hospital (Joshua Frazier, MD)

2005-08 Nephrology Fellowship Scholarship Oversight Committee, Nationwide Children’s Hospital (Franca Iorember, MD)

2002-03 Ohio State University Heart Transplant Committee, The Ohio State University College of Medicine

2000-01 Resident Recruitment Program, Interviewer, The Children’s Hospital of Philadelphia

1998-99 Clinical Pathways Committee, Cardiac Center, The Children’s Hospital of Philadelphia

1994-96 Resident Selection Committee, Department of Pediatrics, WVU School of Medicine

1992-96 Residency Education Committee, Department of Pediatrics, WVU School of Medicine

Quality Improvement Training:

2013 Quality Improvement Essentials Course - Aug through Dec 2013 -Dr. Richard Brilli and Dr. Karen Heiser, Course Coordinators, Nationwide Children’s Hospital

Grants Funded Research – Active:

2016-Present North Carolina Congenital Heart Defects Surveillance Network CDC Multi-center Grant (Duke CCRI principal site) UNC Children’s, University of North Carolina at Chapel Hill Role: Principal Investigator, $20,000 Effort: 2% 2015-Present Pediatric Heart Transplant Study Group.


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NC Children’s Hospital, University of North Carolina at Chapel Hill School of Medicine Role: Principal Investigator, $0 Effort: 2%

Funded Research – Completed:

2007-15 Congenital Cardiac Catheterization Outcomes Project (C3PO). Role: Nationwide Children’s Sub-Investigator, $0 Effort: 5%

2007-15 Pediatric Heart Transplant Study Group. Role: Nationwide Children’s Principal Investigator, $0 Effort: 20%

2012-13 12CRP9020022 Echocardiographic assessment of function during ECMO support. Principal Investigator: Andrew R. Yates, MD American Heart Association NCRP Summer 2011 Clinical Research Program

Role: Senior Sponsor, $110,000 Effort: 15%

2010-12 Can we achieve blunting of the stress response while attempting early extubation after cardiac surgery in children? A Prospective, Randomized Study.

Nationwide Children’s Hospital Heart Center Internal Research Grant Principal Investigator: Aymen Naguib, MD

Role: Senior Sponsor, $50,000 Effort: 15%

2010-12 683011 Delayed umbilical cord clamping in infants with congenital heart disease. American Heart Association Great Rivers Affiliate

Principal Investigator: Carl Backes, MD Role: Senior Sponsor, $121,000 Effort: 15% 2007-08 MI-CP117

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of MEDI-524, a Humanized Enhanced Potency Monoclonal Antibody Against Respiratory Syncytial Virus (RSV), in Children with Hemodynamically Significant Congenital Heart Disease.

Role: Principal Investigator, $68,364 Effort: 15%


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2006-07 EFC5314

CLARINET (Clopidogrel To Lower Arterial Thrombotic Risk In Neonates And Infants Trial) Role: Nationwide Children’s Principal Investigator, $1,800

Effort: 10% 2005-06 MI-CP124

A study to evaluate the safety, tolerability, pharmacokinetics, and immunogenicity of MEDI-524, a humanized enhanced potency monoclonal antibody against respiratory syncytial virus (RSV), in children with hemodynamically significant congenital heart disease. Role: Nationwide Children’s Principal Investigator, $72,056

Effort: 15% 2003-05 A1481134

A randomized, multi-center, double-blind, placebo-controlled, dose-ranging, parallel group study of intravenous sildenafil in the treatment of children, aged 0 to 17 with pulmonary hypertension after corrective cardiac surgery. Role: Nationwide Children’s Principal Investigator, $7,160

Effort: 15% 2003-05 R01-HL053392

Pediatric Cardiomyopathy Registry (funded by NHLBI). Role: Nationwide Children’s Principal Investigator

Effort: 15% 2000-02 EIV7867 Prophylactic intravenous use of milrinone after cardiac operation in

pediatrics (PRIMACORP multi-center clinical trial). Role: National Co-Principal Investigator, Steering Committee Member, and CHOP Principal Investigator, $192,065

Effort: 25% Research Committees

2016- Data Monitoring Committee Member, PANORAMA Pediatric Heart

Failure Study (Pharmacokinetics (PK), pharmacodynamics (PD), safety and efficacy study of LCZ696 in children (1 month to < 18 years) with heart failure due to systemic left ventricle systolic dysfunction). Novartis Phase 2/3

2011-14 Data and Safety Monitoring Board Member, A randomized controlled trial of Hybrid vs Norwood management strategy in children with single ventricle physiology. Site: Toronto Sick Kids

2005-14 Nationwide Children’s Hospital Institutional Review Board


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2013 PumpKIN trial Protocol Review Committee, NHLBI 2009-11 Fontan Research Working Group, Cincinnati Children’s Hospital Core

Research Lab 2009-10 Grant Reviewer, Thrasher Research Fund

2009 Pediatric Heart Network/NIH, Perioperative Working Group, Co-Chair Outcomes and Genomics Committee

2009 FDA Pediatric Clinical Trials Workshop – Cardiovascular Disease Committee

2007-08 Grant Reviewer, Rhode Island Research Alliance, RI Science and Technology Advisory Council

2004-06 Chairman, Data and Safety Monitoring Board, REPEL-CV™ multicenter trial (A Comparative, Evaluator-Masked, Randomized, Parallel, Multicenter Study to Determine the Safety and Effectiveness of REPEL-CV™ for Reducing Post-Operative Adhesions Following Pediatric Cardiothoracic Surgery)

2004-05 Chairman, Pediatric Heart Failure Advisory Panel to Guidant, Inc.

1999-00 FDA Advisory Panel for Primacor (Milrinone) Use in the Pediatric Population

Professional Service To Discipline Leadership Roles in Professional and Scientific Societies:

2017-19 Pediatric Heart Transplant Study Steering Committee Member at Large 2017-19 ABP, Sub-board of Pediatric Cardiology, Credentials Committee

2016-23 American Board of Pediatrics, Sub-board of Pediatric Cardiology 2014-18 American Heart Association, Member, CVDY Pediatric Heart Failure

Committee 2007-15 Treasurer, Pediatric Cardiac Intensive Care Society

2011-15 Lifeline of Ohio Medical Advisory Board 2007-15 Board of Directors, Pediatric Cardiac Intensive Care Society

2010-14 Board of Trustees, American College of Cardiology – Ohio Division 2009-14 American Heart Association, CVDY Liaison to the Council on Clinical

Cardiology’s Heart Failure and Transplantation Committee 2013 American Heart Association Scientific Sessions Abstract Presentation

Program Builder: Myocardial and Pericardial Disease 2010-11 Chairman, Ohio Solid Organ Transplant Consortium Board of Trustee


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Memberships in Professional and Scientific Societies:

2011-present Fellow, American Heart Association (FAHA), Council on Cardiovascular Disease in the Young

2007-present Member, Society for Pediatric Research 2003-present Pediatric Cardiac Intensive Care Society

2002-present International Society for Heart and Lung Transplantation, Council on Pediatric Transplantation

2002-present American Heart Association, Council on Cardiovascular Disease in the Young

1996-present American College of Cardiology, Fellow (F.A.C.C.) 1992-96 American Academy of Pediatrics

1991-96 American Medical Association Editorial Positions:

2008- Editorial Advisory Board, Pediatric Cardiology 2001 Co-editors: Wernovsky G, Hoffman TM, Wessel DL. October 2001

Critical Care Medicine Supplement Vol 29(10):S212-S241. Pediatric Heart Failure Management: Solving the Puzzle.

Journal Reviewer:

1. World Journal for Pediatric and Congenital Heart Surgery (2017-present) 2. Circulation: Heart Failure (2013-present) 3. Congenital Heart Disease (2011-present) 4. Circulation: Cardiovascular Quality and Outcomes (2011-present) 5. Pediatric Cardiology (2008-present) 6. Journal of Pediatrics (2006-present) 7. Pediatrics (2005-present) 8. Circulation (2004-present) 9. Pediatric Transplantation (2003-present) 10. Annals of Thoracic Surgery (2002-present) 11. Journal of Thoracic and Cardiovascular Surgery (2002-present) 12. Critical Care Medicine (2002-present) 13. American Journal of Cardiology (2002-present) 14. American Journal of Transplantation (2014) 15. Journal of Perinatology (2010)


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16. Pediatric Emergency Care (2005) Abstract Reviewer:

1. Cardiology 2011, Scottsdale, Arizona 2. Cardiology 2009, Nassau, Bahamas 3. International Society of Heart and Lung Transplant 2008 Scientific Meeting: Pediatric

Abstract Invited Reviewer Other:

Hospital and Administrative Committees:

2012-15 Nationwide Children’s Hospital UNOS Alternate Institutional Representative

2009-15 Graduate Medical Education Committee, Nationwide Children’s Hospital

2009-15 Resource Research Committee, Co-Chair, Nationwide Children’s Hospital Heart Center

2007-15 Ohio Solid Organ Transplantation Consortium Board of Trustees 2002-15 Ohio Solid Organ Transplantation Consortium

-Pediatric Heart Program Peer Review Committee -Pediatric Heart Patient Selection Committee

2002-15 Transfusion Committee, Nationwide Children’s Hospital 2010-11 United Network for Organ Sharing (UNOS) Region 10 Thoracic Review

Board Member 2008-09 United Network for Organ Sharing (UNOS) Region 10 Thoracic Review

Board Member 2003-05 United Network for Organ Sharing (UNOS), Region 10 Thoracic

Review Board Member 1995-96 Executive Committee, West Virginia University Hospitals


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Research Statement: My research focus has mainly involved cardiac critical care and thoracic organ transplantation and has expanded the gamut of single site to multicenter endeavors. Additionally, I have been fortunate to be involved in scientific statement writing for the American Heart Association as well as for the International Society of Heart and Lung Transplant. I have mentored fellows and junior faculty being the senior sponsor on several initiatives including American Heart Association Grants. I remain an active author for the Pediatric Heart Transplant Study Group which is comprised of over 50 pediatric heart transplant centers and is a multi-center database that begets research that alters the standard of care in this ever changing field. I have been involved in several multi-center trials in pediatric cardiology with a prominent leadership position on the PRIMACORP (Prophylactic Intravenous Use of Milrinone After Cardiac Surgery Operation in Pediatrics) trial but also have served on Data Safety Monitoring Boards, being Chairman of one. I have also been a grant reviewer for outside agencies and have worked with the FDA and NHLBI on several projects and review committees. Finally, I had participated in being a member of the IRB for 9 years and was the Co-Chair of the Research Resource Committee at my previous institution. My author H-index is 22. I am known nationally and internationally for heart transplant and heart failure care and research in pediatrics. I have served on international and national committees regarding pediatric thoracic organ failure and transplant as well as cardiac critical care medicine. I have served in leadership roles for many of the committees and have been an officer for international organizations. I also have written numerous invited review articles, commentaries, and book chapters over the years. I was the National Co-Principal Investigator, a Steering Committee member, and primary author for the PRIMACORP multi-center trial. This is the largest multicenter trial in pediatric cardiac critical care to date to my knowledge. This is my major contribution to science as this was a randomized, double-blind, placebo-controlled trial using 3 parallel treatment groups in pediatric patients undergoing cardiac surgery. Thirty-one centers in North America participated in this study. This trial showed that high dose milrinone was efficacious as compared to low dose and placebo in decreasing the incidence of low cardiac output syndrome postoperatively. This study has been an influence on postoperative care and has been used as a template for practice models across the world. It is a highly cited paper that has continued to be discussed at national and international meetings presently. This paper was mentioned in both “The year in congenital heart disease” and “The year in cardiovascular surgery” for 2004 in the Journal of the American College of Cardiology as a study of great impact on our field (references: Graham TP Jr.. The year in congenital heart disease. JACC 43(11):2132-41, 2004 June 2 and Jones RH. The year in cardiovascular surgery. JACC 43(9):1706-14, 2004 May 5). A sub-analysis of the paper also lead to a description of the pharmacodynamics of the drug in different age groups. I plan to continue to participate on the local, national, and international level in multi-center initiatives and be a mentor to junior faculty and learners.


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Teaching Statement: My approach to teaching ranges from informal and formal lectures, bedside teaching, and mentorship. My aim is to provide lectures that suit the particular audience and attempt to fit a multitude of learning strategies for participants. Over the years, I have provided a tremendous amount of lectures within all institutions I have been involved, however I also receive invitations for international and national meeting lectureships. Bedside teaching, whether inpatient or outpatient, is vital and an emphasis. I have tremendous experience with graduate medical education as I was the Pediatric Cardiology Fellowship Program Director for 6 years at my previous institution. During my time as director, the program enhanced its national reputation and was able to increase its allotment of fellows per year. The curriculum was also redesigned and developed further with not only rotation specific goal enhancement but also a wide expansion of learning opportunities. Additionally, during my administrative duties at my previous institution and at present, I am an active mentor in research and grant support for learners and junior faculty. I also feel career transitions and development are important and can certainly be an aspect of teaching and mentoring. Finally, I have mentored several residents since arriving to UNC as an advisor to help foster their interest in cardiology as a career. I have been instrumental in guidance as they approach their fellowship applications. Service and Engagement Statement: I am a Pediatric Heart Failure and Heart Transplant specialist and was the Medical Director of these programs at my previous institutions. I am an inaugural invited member of the Cardiovascular Disease in the Young American Heart Association Pediatric Heart Failure Committee and have focused on development of quality improvement and best practices over the last several years. I am engaged on a national level additionally as an American Board of Pediatrics Sub-board of Pediatric Cardiology member through 2023. As Division Chief, I am dedicated to delivering the highest quality of care and provide depth of pediatric cardiology subspecialty services to the children of North Carolina. I have a strong strategic vision for enhancing the national footprint of the Division, clinical growth, contributing and fostering research and quality improvement initiatives, and facilitating faculty career development. I want to foster multidisciplinary collaboration and develop clinical service lines for our patients to allow for comprehensive expert care. I will assure Departmental initiatives are met and in alignment with strategic planning.

Documents

CURRICULUM VITAE TIMOTHY M. HOFFMAN, MD, FACC, …...Timothy M. Hoffman, MD, FACC, FAHA October 2018 Curriculum Vitae 5 12. Hoffman TM, Welty S. Physiology of the pre-term and term