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Date Prepared: May 1, 2018 CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate Zoology, Minor: Chemistry Memphis State University, M.S., 1983 Biology Major: Vertebrate Zoology University of Memphis, Ph.D., 1997 Microbiology & Molecular Cell Sciences AWARDS: Kennedy Book Club Scholarship for academic year 1974-1975 Gooch Scholarship for academic year 1975-1976 SOCIETY MEMBERSHIPS: American Museum of Natural History Memphis Zoological Society Orthopaedic Research Society American Society for Bone and Mineral Research Elected Fellow of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2005 Biomedical Engineering Society Society for Biomaterials UNIVERSITY APPOINTMENTS: 2012-Present: Associate Professor/Graduate Program Director, Department of Ortho Surgery & BME 2010-2012: Interim Graduate Program Director, Department of Orthopaedic Surgery & BME 2001-2012: Tenure-Track (tenured, 2008) Assistant Professor, Department of Orthopaedic Surgery 1997-2001: Non-tenure track Assistant Professor, Department of Orthopaedic Surgery, UTHSC 1992-1997: Technical Director, Department of Orthopaedic Surgery, UTHSC 1985-1992: Research Associate, Department of Orthopaedic Surgery, UTHSC 1983-1985: Research Assistant, Department of Pharmacology, UTHSC 1979-1983: Graduate Teaching & Research Assistant, Memphis State University OTHER ACADEMIC APPOINTMENTS: 2012-Present: Graduate Faculty, UTHSC/UM Joint Program in Biomedical Engineering 1998- 2012: Adjunct Graduate Faculty, UTHSC/UM Joint Program in Biomedical Engineering 1998- Present: Adjunct Graduate Faculty, Department Mechanical Engineering, University of Memphis 1988- Present: Adjunct Graduate Faculty, Department of Biology, University of Memphis PRIVATE SECTOR APPOINTMENTS: 1992- Present: Consultant, The Campbell Foundation, Campbell Clinic, Memphis, TN 2003-2005: Consultant, Erwin, Fitch and Associates, New Orleans, LA 2003- 2006: Consultant, Smith & Nephew Inc., Memphis, TN TEACHING EXPERIENCE: Graduate

CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

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Page 1: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Date Prepared: May 1, 2018

CURRICULUM VITAE

Richard A. Smith, B.S., M.S., Ph.D.

EDUCATION:

Memphis State University, B.S., 1979 Biology, Major: Vertebrate Zoology, Minor: Chemistry

Memphis State University, M.S., 1983 Biology Major: Vertebrate Zoology

University of Memphis, Ph.D., 1997 Microbiology & Molecular Cell Sciences

AWARDS:

Kennedy Book Club Scholarship for academic year 1974-1975

Gooch Scholarship for academic year 1975-1976

SOCIETY MEMBERSHIPS:

American Museum of Natural History

Memphis Zoological Society

Orthopaedic Research Society

American Society for Bone and Mineral Research

Elected Fellow of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2005

Biomedical Engineering Society

Society for Biomaterials

UNIVERSITY APPOINTMENTS:

2012-Present: Associate Professor/Graduate Program Director, Department of Ortho Surgery & BME

2010-2012: Interim Graduate Program Director, Department of Orthopaedic Surgery & BME

2001-2012: Tenure-Track (tenured, 2008) Assistant Professor, Department of Orthopaedic Surgery

1997-2001: Non-tenure track Assistant Professor, Department of Orthopaedic Surgery, UTHSC

1992-1997: Technical Director, Department of Orthopaedic Surgery, UTHSC

1985-1992: Research Associate, Department of Orthopaedic Surgery, UTHSC

1983-1985: Research Assistant, Department of Pharmacology, UTHSC

1979-1983: Graduate Teaching & Research Assistant, Memphis State University

OTHER ACADEMIC APPOINTMENTS:

2012-Present: Graduate Faculty, UTHSC/UM Joint Program in Biomedical Engineering

1998- 2012: Adjunct Graduate Faculty, UTHSC/UM Joint Program in Biomedical Engineering

1998- Present: Adjunct Graduate Faculty, Department Mechanical Engineering, University of Memphis

1988- Present: Adjunct Graduate Faculty, Department of Biology, University of Memphis

PRIVATE SECTOR APPOINTMENTS:

1992- Present: Consultant, The Campbell Foundation, Campbell Clinic, Memphis, TN

2003-2005: Consultant, Erwin, Fitch and Associates, New Orleans, LA

2003- 2006: Consultant, Smith & Nephew Inc., Memphis, TN

TEACHING EXPERIENCE:

Graduate

Page 2: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 2 Richard A. Smith, PhD.

1995: Smith & Nephew Inc. Lecture Series: Basic Biology for Mechanical Engineers with Emphasis on

Bone and Orthopaedics. Series of 17, 90 minute lectures given at Smith & Nephew Inc. to their

Research and Development employees. Course Director and Instructor.

2003: UTHSC School of Dentistry Cartilage Histology Course Lecture; Lecturer

2002- 2011: 16 Graduate 90 minute lectures/Fall in UTHSC/UM Joint Program in

Biomedical Engineering Life Science I BIOM 811; Lecturer

2012: 19 Graduate 90 minute lectures/Spring in UTHSC/UM Joint Program in

Biomedical Engineering Life Science II BIOM 821; Lecturer

2003- Present: 2 Graduate 90 minute lectures on Biomaterials and Advanced Biomaterials/year in

BIOM 885 & 886

2012-Present: 1 Graduate 90 minute lecture in Materials and Regulations in Biomedical Development

BIOM 609, Special Topics

2001- 2011: Rheumatology Journal Club

2002- 2013: Bone Metabolism Journal Club

2008-Present: Rheumatology Fellow one hour Lecture/year; Prosthetic Joint Loosening

2011-Present: 16 Graduate 90 minute lectures/year in UTHSC/UM Joint Program in

Biomedical Engineering, Life Science BIOM 811; Course Director/Lecturer

2011-Present: 20 Graduate 90 minute lectures/year in UTHSC/UM Joint Program in

Biomedical Engineering, Life Science BIOM 821; Course Director/Lecturer

1997- Present: Residents Core Curriculum Lectures, 3 Basic Science 2 hour lectures/year given:

Basic Bone Biology, Growth Plate and Bone Development, Molecular and Cellular

Biology of Inflammation and Neoplasia in the Musculoskeletal system, Bone Injury

Regeneration and Repair, Bone Metabolic Diseases, Research Methodology and Design,

Prosthetic Joint Loosening, Biostatistics.

2014-Present: 2 Graduate 90 minute lectures in UTHSC/UM Joint Program in Biomedical Engineering,

Instrumentation BIOM 815

Undergraduate

1987–2010: Human Anatomy and Physiology I and II night course at University of Memphis,

Department of Biology

1979-1985: Human Anatomy and Physiology (lecture & lab), Histology, Life Science, General Biology,

Human Perspectives, General Zoology lab, Honors Zoology lab, Genetics (lecture & lab),

Embryology lab, Human Physiology labs, Comparative Animal Physiology labs, Comparative

Anatomy of Vertebrates (lecture & lab), Coordinator of the General Zoology and Comparative

Anatomy of Vertebrates labs (responsible for direction of teaching assistants and development of

laboratory-based teaching program). All courses taught at the University of Memphis.

Total of 38 INVITED LECTURES including from the last ten years:

Introduction to Orthopaedic Biomaterials and Bone Remodeling

Invited Lecture to Undergraduates Alfred University, Alfred, New York, 2001

Cell Adhesion and Responses to Orthopaedic Biomaterials

Invited Seminar Speaker Alfred University, Alfred, New York, 2001

Introduction to Orthopaedics, Bone Remodeling and Osteolysis

Department of Physiology and Health Science, Ball State University, Muncie, Indiana, 2001

Page 3: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 3 Richard A. Smith, PhD.

Introduction to Orthopaedics and Osteolysis

Department of Physiology and Health Science, Ball State University, Muncie, Indiana, 2002

Studies on Osteolysis and a Unique Bone Biomatrix

Veterans Administration Hospital Seminar Memphis, TN, 2002

Total Joint Replacement and Osteolysis

Department of Biology, University of Central Arkansas, Conway, Ark, 2002

Introduction to Orthopaedics: Bone Remodeling and Osteolysis

Christian Brothers University Junior Seminar Series, Memphis, TN, 2003

Bone Histology

University of Memphis, Department of Biology 1.5 hour lecture, 2005

Histology of Bone and Cartilage,

University of Memphis, Department of Biology 2x 1.5 hour lectures, 2006

Osteolysis and Endotoxin

Christian Brothers University Junior Seminar Series, Memphis, TN, 4/10/2007

Basic Science Research Advances For Articular Cartilage Defects

Clinical Orthopaedic Society 95th annual meeting, Memphis, TN. 9/27/2007

Orthopaedic Research

Christian Brothers University Junior Seminar Series, Memphis, TN, 4/12/2011

Clinical Grand Challenges for Biomaterials Innovation

Invited Moderator for Biomaterials Day, Society for Biomaterials 2/17/2012

Studies on Bone and Enthesis Healing

Tennessee Chapter American Association for Dental Research, 11/13/2012

Animal Models for Bone Healing

Christian Brothers University Junior Seminar Series, Memphis, TN, 4/12/2013

Academia

Moderator for Biomaterials Day, Society for Biomaterials 2/17/2016

Biomedical Engineering

Baptist College of Health Sciences, BMD Seminar Series, 2/27/2017

COMMITTEES AND OFFICES HELD:

1981: Local Committee for the Joint Annual Meeting of the SSAR and of the Herpetologist

League

Page 4: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 4 Richard A. Smith, PhD.

2005-2006 Faculty on Liaison Committee for Medical Education (LCME)

2007-2009: HSC Faculty Development Educational Task Force

2003-2012 UTHSC Faculty Senate

2003-2006: Educational Policy Committee of Faculty Senate

2006-2010: Chair Educational Policy Committee of Faculty Senate (Exceptional Meritorious

Achievement Award 2007-2008)

2010- 2012: Secretary/Treasurer UTHSC Faculty Senate (Exceptional Meritorious

Achievement Award 2011-2012)

2010- 2012: UTHSC Faculty Grievance Committee

2011-2012: Memphis Research Consortium Search Committee- Stem Cell Biologist

2013: Orthopaedic Surgery & BME Departmental Promotion & Tenure Committee

2013: UTHSC College of Graduate Health Sciences Associate Dean Search Committee

2011-present: UTHSC Graduate Studies Council

1995-present: Orthopaedic Surgery Departmental Research Committee

2003-present: UTHSC College of Medicine Faculty/Peer Mentor Program

2011-Present: BME Joint Program Level A Exam Committee

2015 BME Joint Program Level A Exam Committee Chair

2016 Graduate Health Science Appeals Committee

2016 Office of Research Integrity Scientific Misconduct Investigation Panel

2016 UTHSC Anatomy Trouble-Shooting Committee

2016 Faculty Senate Executive Committee (COM-Clinical)

2016-Present UTHSC Faculty Senate

2016-Present Chair, Faculty Senate Faculty Affairs Committee

2016-Present Faculty Affairs Working Group

2016-Present UTHSC Faculty Grievance Committee (2)

2016-Present Quality Enhancement Program (QEP) Steering Committee (Assessment subcommittee)

2016-Present Faculty Resource Fair and Social Planning Committee

2018 Faculty Search Committee, UM Biomedical Engineering

Ad Hoc Reviewer for the Following Scientific/Clinical Journals, Books, Grants:

Clinical Orthopaedics and Related Research

BONE

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Journal of Biomedical Materials Research Part A:

Journal of Adhesion

Journal of Orthopaedic Research

Inflammation Research

Plos One

Bioelectrochemistry

Annals of Biomedical Engineering

Connective Tissue

Pharmaceutical Research

Journal of Long-Term Effects of Medical Implants

Journal of Biomaterials Application

Biomedical Materials

Biofabrication

Page 5: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 5 Richard A. Smith, PhD.

Artificial Organs

Open Orthopaedics Journal

Reviewer for the Israel Science Foundation

Reviewer for MSRP

Reviewer for iRISE Pilot Projects Grants

Reviewed Chapters 5-8 in Essential Cell Biology, Fourth Edition, by Alberts, et al.

OTHER PROFESSIONAL AFFILIATIONS AND ACTIVITIES:

2000-2002: Initiator and coordinator for Community Orthopaedic Research Meetings

Monthly meeting involving, local surgeons, companies and researchers interested in

orthopaedic related problems

2005: Abstract Selection Committee for Orthopaedic Research Society Meeting

2006: Abstract Selection Committee for Orthopaedic Research Society Meeting

2006: Moderator for Orthopaedic Research Society Meeting, Infection and Inflammation

Session

2007: Abstract Selection Committee for the Combined Orthopaedic Research Society Meeting

2007: Moderator for the Combined Orthopaedic Research Society Meeting, Bone Mechanics

and Adaptation Session

2010-2013: Abstract Selection Committee for Orthopaedic Research Society Meeting

2015 Abstract Selection Committee for Orthopaedic Research Society Meeting

2009-2011: Moderator & coordinator for the Memphis Orthopaedic Research Seminar Series

2011-2017: Moderator & coordinator for the Memphis Orthopaedic Research Education Panel

FELLOWS/GRADUATE STUDENTS TRAINED:

Orthopaedic Residents and Fellows:

Joseph Dutkowsky, Andy Kaplan, James Canady, Rob Williams, Masahito Hatori, Douglas

Calhoun, Douglas Hiller, Darren Keiser, John Lochemes, Anant Kumar, William Gramig, Scott

Edwards, Tyler Cannon, Byron Stephens, Jae Ahn

Current Graduate Student Committees:

Allison Fetz (MS, 2018) UTHSC/UM Joint Program in Biomedical Engineering

William (Hunter) King (PhD)* UTHSC/UM Joint Program in Biomedical Engineering

Vishnu Priya Murali (PhD) UTHSC/UM Joint Program in Biomedical Engineering

Griffin Heise (MS) UTHSC/UM Joint Program in Biomedical Engineering

Ben Minden-Birkenmaier (PhD) UTHSC/UM Joint Program in Biomedical Engineering

Huda Muslih Almabadi (PhD, 2018) UTHSC/UM Joint Program in Biomedical Engineering

Meredith Perkins (MS, 2018) UTHSC/UM Joint Program in Biomedical Engineering

Diego Pulgarin (MS, Fall 2017) UTHSC/UM Joint Program in Biomedical Engineering

Post-Doctoral Fellow:

Zhiqing Xing, M.D., Ph.D. 2003-2005

Committee Chair for the following Graduate Students:

Andy Hardison, M.S. in Biomedical Engineering “Analysis of the Thermo-Chemical Stability of

Ultra High Molecular Weight Polyethylene using Isothermal Microcalorimetry” Defended 2001.

Page 6: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 6 Richard A. Smith, PhD.

Luciana Schwab, Ph.D. in Molecular Cell Sciences, The University of Memphis; Department:

Biology “Murine Macrophage Response to Titanium Particles Depends on Particle Load,

Presence of LPS and Serum Concentration In Vitro: Implications in Periprosthetic Osteolysis”

Defended 2006.

Carie Alley, M.S. in Biomedical Engineering “The Effect of Polyethylene Wear Debris Size,

Number, and Endotoxin on the Macrophage Osteolytic Response” Defended 2007.

*William (Hunter) King, Ph.D. in Biomedical Engineering “

Co-Chair with Gary Bowlin.

Member of committee for the following graduate students:

Joe Turner, M.S. in Biomedical Engineering, 2000

Steve Charlebois, Ph.D. in Mechanical Engineering, 2001

Jinsong Huang, M.D., Ph.D. in Biomedical Engineering, 2004

Bahram Dahi, Ph.D. in Biomedical Engineering and Imaging, 2009

Duong Nguyen, M.S. in Biomedical Engineering, 2010

Danielle Muller M.S. in Biomedical Engineering, 2010

Anobel Maghsoodpour Ph.D. in Biomedical Engineering and Imaging, 2010

Hannah Schackelford, M.S. in Molecular Cell Sciences, The University of Memphis 2012

Lauren Eichaker M.S. in Biomedical Engineering, 2013

Nina Poole Ph.D. in Molecular Cell Sciences, The University of Memphis 2013

Jared Cooper, Ph.D. in Biomedical Engineering, 2013

Matt Goodhart, M.S. in Biomedical Engineering, 2013

Monica Zugravu, M.S. in Biomedical Engineering, 2013

Ben Reves, Ph.D. in Biomedical Engineering, 2013

Jordan Leumas, M.S. in Molecular Cell Sciences, The University of Memphis 2014

Keegan Compton, M.S. in Biomedical Engineering, 2015

James Atherton, M.S. in Biomedical Engineering, 2015

Christopher Gehrmann, M.S. in Biomedical Engineering, 2016

Gretchen S. Selders, M.S. in Biomedical Engineering, 2016

Medical Students trained in lab:

1987 Mark Dodson Research Fellowship Program NIH, “The Angiogenic Effects of Fibroblast

Growth Factor-basic as compared to Controls in the Chicken Chorioallantoic Membrane Assay”

1988 Jeff Fuqua, Bill Gramig “FGFbeta effects on a rabbit achilles tendon defect model”

1991 Paul Becker Research Fellowship Program NIH “A Laboratory Model for Testing the Delivery

of Antibiotics in Osteomyelitis”.

1992 Mike Patterson Research Fellowship Program NIH “Elution of Antibiotics from

Polymethylmethacrylate beads, collagen sponge and Polylactic acid beads”.

1993 Stephanie Becker Research Fellowship Program NIH “Testing for Measles RNA Sequences in

Paget’s Bone Disease with Polymerase Chain Reaction”.

1999 Geoff Watson “Development of a rat osteolysis model”.

2000 Frank Barnes “Evaluation Of Possible Inhibitors Of Osteolysis In A Rat Model”.

2002 Patrick Emerson “Development Of An Animal Model For Evaluating The Microbial Debris Hypothesis

Of Wear Particle Mediated Osteolysis”.

Page 7: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 7 Richard A. Smith, PhD.

2008 Justin Marlar “The mechanism of osteocalcin control of energy metabolism”.

2009 Spencer Hauser Research Fellowship Program NIH “In Vitro Macrophage Response to

Conventional and Cross-Linked Ultrahigh Molecular Weight Polyethylene”.

2011 Alex Caughran “PRP enhanced enthesis healing in a rat”.

2011 Andrew Wodowski “Comparison of blood, steroid and PRP in a rat tendonosis model”.

2013 Levon Djenderedjian “Effects of Gelsolin on Macrophage Inflammatory Responses to Implant

Wear Debris“

2014 Charlie Xie “Effects of Gelsolin on Macrophage Inflammatory Responses to Implant Wear

Debris“

2016 Dexter Powell “In vivo Peri-Implant Response to Chitosan Coatings“

2017 Ryan Carpenetti “Effects of Raspberry Ketone on Human Macrophage Polarization”

2017 Barbara Smith “PGE₂ Mitigates Macrophage Inflammatory Cytokine Responses”

2018 Caitlin Black “Determining biocorrosion of implant materials by macrophage activation”

Mentor for the Following College of Allied Health Science CLS Students:

2002: Beth Roberts, B.S. Detection of Bacterial Endotoxin in patient Tissue Samples Using Limulus

Amoebocyte lysate Assay

2003: Theresa Halliday, in vitro cytokine production in response to different cell to particle and serum

concentrations. (Sigma Xi award for Undergraduate research)

2004: Karine Dunn, B.S. Preliminary Developmental Studies of an In Vitro Assay for Osteolysis

Induced by Titanium Debris following Total Hip Replacement

2005: Deidra Whitt, B.S. Determining the type of movement that causes maximum production of

PGE2 by macrophages in vitro (Sigma Xi award for Undergraduate research)

2006: Kevin McHugh, B.S. Cell Viability Potential with Different Concentrations of Serum and in

vitro Production of TNF- by Macrophages under Differing concentrations of Serum and

Differing Incubation Periods

2007: Kathryn Binkely, M.S. Cell Viability Potential with Different Concentrations of Serum and in

vitro Production of TNF- by Macrophages under Differing concentrations of Serum and

Differing Incubation Periods

2008: Kimberlee Cates, M.S. MMP production by macrophages exposed to titanium, cross-linked

ultrahigh molecular weight polyethylene and polycarbonate urethane particles

2015: Lekeisha Poplar, M.S. PGE₂ Mitigates Macrophage Inflammatory Cytokine Response to Particles

2017: Josh Paschall, M.S. Effects of HMGB1 on Human Macrophage Polarization

Undergraduate Students trained:

Ryan Tomlinson (CBU, 2015), Karina Chavez (CBU, 2014), Charlene Patino (CBU, 2014),

Shannon McDonald (CBU, 2013), Emily DiAngelo (UTK), Christian Bahniuk, (CBU, 2012),

Johnny Timmerman (CBU, 2011), Kathleen Nelson (CBU, 2011), Kaylea Brewer (CBU 2010),

Brooke Allen (CBU, 2009), Scott Berry (CBU, 2008), Brian Walters (CBU, 2007), Bobby

Lawrence (CBU, Dominic Dunn Award Winner, 2006), Andrew Michael (CBU, 2005), Al

Narvaez (CBU, 2004)

Kappa Delta Summer Interns trained:

2010-2011 Brittany Chavez (Rhodes)

2008 Whitney Gabb (Ole Miss)

2007 Danielle Helton (Baylor)

Page 8: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 8 Richard A. Smith, PhD.

RESEARCH AND OTHER EXTERNAL SUPPORT:

1986 - 1987 Hugh Smith, M.D. Research Grant, Campbell Foundation

“The Effect of Thyroid Hormones on the Growth of a Ewing's Sarcoma Cell Line in

Tumor Culture – A Pilot Study”

Co-PI with Joe Dutkowsky, M.D. $2000

1987 Medical Student (Mark Dodson) Research Fellowship Program NIH,

“The Angiogenic Effects of Fibroblast Growth Factor-basic as compared to Controls in

the Chicken Chorioallantoic Membrane Assay” $3000

1987 – 1988 Orthopaedic Research and Education Foundation,

“The Effect of Thyroid Hormones on the Growth of aNeoplastic Cells in Tumor Culture”

Co-PI with Joe Dutkowsky, M.D. $15,000

1989 – 1990 Orthopaedic Research and Education Foundation,

“Bone Targeted Therapy for Osteomyelitis: Coupling of a Biphosphonate to a

Bactericidal Agent”

Co-PI with Andy Kaplan, M.D. $15,000

1991 Medical Student (Paul Becker) Research Fellowship Program NIH

“A Laboratory Model for Testing the Delivery of Antibiotics in Osteomyelitis. $3000

1990 - 1992 Orthopaedic Research and Education Foundation,

“Identification of the Molecular Basis for the Effect of Fetal Thyroid Hormone on

Neoplastic Cells in Tumor Culture”

Co-PI with Joe Dutkowsky, M.D. $80,000

1992 Medical Student (Mike Patterson) Research Fellowship Program NIH

“Elution of Antibiotics from Polymethylmethacrylate beads, collagen sponge and

Polylactic acid beads” $3000

1993 Medical Student (Stephanie Becker) Research Fellowship Program NIH

“Testing for Measles RNA Sequences in Paget’s Bone Disease with Polymerase Chain

Reaction” $3000

1993 – 1994 University of Tennessee Medical Group Research Grants Program,

“Slow Neutron Capture Radioimmunotherapy for Sarcomas”

Co-PI with Joe Dutkowsky, M.D. $12,500 Award # A94-0772-001

1995 Unrestricted Educational Grant for Development of a Bone Biology Course.

Smith & Nephew Richards Inc. $7,650 PI

1996 Industry Grant, “Exploratory Study: Estimating Storage Stability Of Implant Materials

By Microcalorimetry” Co-Investigator with A. U. Daniels, Ph.D. $6,209 Award #A97-

0892-001

Page 9: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 9 Richard A. Smith, PhD.

1997- 1998 Phase I STTR NIAMS grant, Reference number 1 R41 AR 44581-01

“Phagocyte Implant Wear Particle Microcalorimetry”

Co-PI with Ed Lewis, Ph.D. and A. U. Daniels, Ph.D. $99,893

1999 – 2000 NSF Industry/University Center for Biosurfaces

“Stability of Ultra-High Molecular Weight Polyethylene Implant Materials Determined

by Isothermal Microcalorimetry (IMC)” PI $24,975

2001- 2002 Smith & Nephew, Inc. “In Vivo Evaluation of JAX™ Calcium Sulfate Bone Void Filler”

PI $72,545 Award #A02-1012-001

2002-2005 Rheumatic Diseases Research Core Center DHHS - NIH - National Institute of Arthritis

and Musculoskeletal and Skin Diseases $552,099.00 Award # A02-0804-003

Investigator, 2002-2004 Andrew Kang PI, 2005 Arnold Postlethwaite PI

2002- 2003 Smith & Nephew, Inc. “In Vivo Evaluation of the Angiogenic Effects of Monobutyrin

Delivered Using a JAX® Bone Void Filler” PI $64,877 Award #A03-0706-001

2002 – 2003 Smith & Nephew, Inc. “In Vivo Evaluation of the Bone Healing Effects of Follistatin”

PI $24,709, Award # A03-0706-001

2002 – 2003 Center of Excellence for Diseases of Connective Tissue Pilot and Feasibility Grant

“Comparison of a loose implant and implant with wear debris in a rat model”

PI $20,000

2003 Shared Instrumentation Grant NIH “MicroCT II Small Animal Imaging System”

Faculty Participant $427,000, Karen Hasty PI

2004 Smith and Nephew, Inc. “Platelet Concentration by Filtration: Development of

Techniques and Proof of Concept”

Co-PI with Lisa K. Jennings, Ph.D. $ 47,565

2003-2004 Smith & Nephew, Inc. “Evaluation and Cellular Interactions of Polyethylene and Its

Wear Products, Phase I” PI $ 43,694 Award # A03-0879-001

2004 – 2006 Smith & Nephew, Inc. “Evaluation and Cellular Interactions of Polyethylene and Its

Wear Products, Phase II” PI $ 48,424 Award # A03-0879-003

2005 Smith and Nephew, Inc. “Effects of the Exogen Ultrasound System of a 2mm Rabbit

Fibular defect” PI $97,214 Award # A05-0760-001

2005 Smith & Nephew Educational Grant PI $7,124 Award #A06-0724-001

2007 Active ImplantsTM Corporation “In Vitro Macrophage Response to Polyethylene and

Polyurathane Particles” PI $24,035

Page 10: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 10 Richard A. Smith, PhD.

2007 Active ImplantsTM Corporation “In Vivo Response to Polyethylene and Polyurathane

Particles” PI $56,747

2009 Active ImplantsTM Corporation “In Vitro Macrophage Response to Conventional and

Cross-Linked Ultrahigh Molecular Weight Polyethylene” PI $39,974 A09-0757-001

2009 Medical Student (Spencer Hauser) Research Fellowship Program NIH

“In Vitro Macrophage Response to Conventional and Cross-Linked Ultrahigh Molecular

Weight Polyethylene” $4000

2010-2012 “Enhanced soft tissue attachment and fixation using a mechanically-stimulated cytoselective

tissue-specific extracellular matrix coating” CDMRP grants U.S. Department of Defense,

Subcontract with Warren Haggard, Ph.D. at University of Memphis. $100,000 Funded Award #A11-0552-001 subcontract $31,000

2011-2012 “Enhanced Preclinical Evaluation and Assessment of Bone Graft Biomaterials”, Memphis

Research Consortium, $90,000 Subcontract with Warren Haggard, Ph.D. at University of

Memphis. Funded Award # A12-0107-001 subcontract $68,000

2010-2011 “Comparative efficacy of autologous blood and platelet rich plasma in treating

tendinopathy” American Society for Surgery of the Hand, 2010-2011, Investigator, $20,000,

James H. Calandruccio PI

2012-2013: “Evaluation of AmnioTMT material to augment healing of DBM in a rat calvarial model as

compared to DBM alone”; Study Sponsor: AmniGenix, LLC; Consultant role

6/13-9/13 “Viability characterization of processed amniotic membrane”

BioDLogics, LLC; Co-PI with Amber Jennings $3,000

2013-2017: “Stem cell response to chitosan coatings on musculoskeletal implants”

Memphis Research Consortium PAMS 15-0651

CO-PI with Amy Abell and Joel Bumgardner (UM)

Total budget: $100,000; Subcontract budget: $27,695

2017-2021: “Chitosan Guided Bone Regeneration Membranes for Dual Local Delivery of Simvastatin

and Raspberry Ketone” NIH Award 1R01DE026759-01, PI Dr. Joel Bumgardner

(University of Memphis) with subaward to the University of Tennessee Health Science

Center, Dr. Richard Smith serving as Co-Principal Investigator along with Dr. Franklin

Garcia-Godoy.

Peer-reviewed Journal Publications for last 10 years:

Page 11: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 11 Richard A. Smith, PhD.

38. Xing, Zhiqing, Schwab. L., Alley, C., Hasty, K, Smith, R Titanium Particles That Have Undergone

Phagocytosis by Macrophages Lose the Ability to Activate Other Macrophages" J Biomed Mater Res B

Appl Biomater. 2008 Apr;85(1):37-41. PMID:17696147

39. Heck RK, Pope WD, Ahn JI, Smith RA, Webber BL. Histologic evaluation of the depth of necrosis

produced by argon beam coagulation: implications for use as adjuvant treatment of bone tumors.

J Surg Orthop Adv. 2009 ;18(2):69-73. PMID:19602333

40. Cummings JE, Smith RA, Heck RK Jr. Argon Beam Coagulation as Adjuvant Treatment after Curettage of

Aneurysmal Bone Cysts: A Preliminary Study. Clin Orthop Relat Res. 2010 Jan;468(1):231-7.

41. Smith RA, Maghsoodpour A, Hallab NJ. In Vivo Response to Polyethylene and Polyurethane

Particles J Biomed Mater Res A. 2010 Apr;93(1):227-34. PMID: 19557792

42. Smith RA, Hallab NJ In Vitro Macrophage Response to Polyethylene and Polyurethane Particles J

Biomed Mater Res A. 2010 Apr;93(1):347-55. PMID: 19569215

43. Slominski AT, Li W, Bhattacharya SK, Smith RA, Johnson PL, Chen J, Nelson KE, Tuckey RC,

Miller D, Jiao Y, Gu W, Postlethwaite AE. Vitamin D Analogs 17,20S(OH)(2)pD and

17,20R(OH)(2)pD Are Noncalcemic and Exhibit Antifibrotic Activity. J Invest Dermatol. 2011

May;131(5):1167-9. Epub 2011 Jan 13 PMID: 21228816

44. Schwab LP, Marlar J, Hasty KA, Smith RA Macrophage response to high number of titanium

particles is cytotoxic and COX-2 mediated and it is not affected by the particle's endotoxin content or

the cleaning treatment. J Biomed Mater Res A. 2011 Dec 15;99(4):630-7. PMID: 21954011

45. Nguyen DT, McCanless JD, Mecwan MM, Noblett AP, Haggard WO, Smith RA, Bumgardner JD.

Balancing mechanical strength with bioactivity in chitosan/calcium phosphate 3D microsphere scaffolds

for bone tissue engineering: air- versus freeze-drying processes J Biomater Sci Polym Ed.

2013;24(9):1071-83 PMID: 23683039

46. Zugravu MV, Smith RA, Reves BT, Jennings JA, Cooper JO, Haggard WO, Bumgardner JD.

Physical Properties and In Vitro Evaluation of Collagen-Chitosan-Calcium Phosphate Microparticle-

Based Scaffolds for Bone Tissue Regeneration J Biomater Appl. 2013 Nov;28(4):566-79 PMID:

23128039

47. Cho H, Park SH, Park K, Shim JW, Huang J, Smith R, Elder S, Min BH, Hasty KA. "Construction

Of A Tissue-Engineered Annulus Fibrosus" Thoughts & Progress Artificial Organs 2013

Jul;37(7):E131-8. doi: 10.1111/aor.12066. Epub 2013 Apr 29. PMID:23621741

48. Poole NM, Mamidanna G, Smith RA, Coons LB, Cole JA Prostaglandin E2 in tick saliva regulates

macrophage cell migration and cytokine profile Parasit Vectors. 2013 Sep 11;6(1):261.

PMID: 24025197

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Curriculum Vitae Page 12 Richard A. Smith, PhD.

49. Jared O. Cooper, Joel D. Bumgardner, Judith A. Cole, Richard A. Smith, Warren O. Haggard

Scaffold Considerations for Tendon- Bone Interface Engineering J. Funct. Biomater. 2013, 4, 1-x

manuscripts; doi:10.3390/jfb40x000x

50. Alley, C., Haggard, W., Smith, R. Effect of UHMWPE Particle Size, Dose, and Endotoxin on in

vitro Macrophage Response Journal of Long-Term Effects of Medical Implants 24(1): 47–58 (2014)

51. William M Mihalko, Lev Djenderedjian, Paramjeet S Cheema, & Richard Smith Effects of

Gelsolin on Macrophage Inflammatory Responses to Orthopaedic Implant Wear Debris Journal of

Long-Term Effects of Medical Implants, 24(1): 59–65 (2014)

52. Cusick MC, Bonnaig NS, Azar FM, Mauck BM, Smith RA, Throckmorton TW. Accuracy and

reliability testing of the Mayo Elbow Performance Score. J Hand Surg Am. 2014 Jun;39(6):1146-50.

PMID:24656392

53. Goodhart, J.M.; Cooper, J.O.; Smith, R.A.; Williams, J.L.; Haggard, W.O.; Bumgardner, J.D. Design

and Validation of a Cyclic Strain Bioreactor to Condition Spatially-Selective Scaffolds in Dual Strain

Regimes. Processes 2014, 2, 345-360; doi:10.3390/pr2020345. http://www.mdpi.com/2227-

9717/2/2/345

54. Hall J, Miller R, Conoley J, Martinez S, Hyden J, Avila J, Smith R, Azar FA, Throckmorton TW.

Accuracy and reliability testing of two methods for measuring internal rotation of the glenohumeral

joint. J Shoulder Elbow Surg. 2014 Sep;23(9):1296-300. doi: 10.1016/j.jse.2013.12.015. Epub 2014

Mar 4. PMID: 24618193

55. Cooper JO, Bumgardner JD, Cole JA, Smith RA, Haggard WO. Co-cultured tissue- specific

scaffolds for Tendon/Bone Interface Engineering J Tissue Eng. 2014 Jul 7;5: PMID: 25383167

56. Stephens B, Smith RA, Williams K. The Clinical Utility of MRI for Cervical Spine Evaluation and

Clearance Following Blunt Trauma Spine Oct. 2014, DOI: 10.1016/j.spinee.2014.08.290

57. Amini MH, Sykes JB, Olson ST, Smith RA, Mauck BM, Azar FM, Throckmorton TW. Reliability

testing of two classification systems for osteoarthritis and post-traumatic arthritis of the elbow.

J Shoulder Elbow Surg. 2015 Mar;24(3):353-7. doi: 10.1016/j.jse.2014.10.015. Epub 2014 Dec 23.

PMID: 25541343

58. Alexander T, Azar FM, Mauck B, Smith R, Throckmorton TW The Effect of Humeral Rotation on

Elbow Range-of-Motion Am J Orthop (Belle Mead NJ). 2015 Feb;44(2):73-6. PMID: 25658075

59. Murphy, R.F., Azar, F.M., Mauck, B.M., Smith, R., & Throckmorton, T.W. Accuracy testing of

four physical examination maneuvers for detecting lateral epicondylitis. Current Orthopaedic Practice

July/Aug 2015;26(4):367-70

60. Cho H, Holt DC, Smith RA, Kim S-J, Gardocki RJ, Hasty KA: The Effects of Platelet Rich Plasma

on Halting the Progressive in Porcine Intervertebral Disc Degeneration " Artificial Organs 2015 40(2)

PMID 26147759

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Curriculum Vitae Page 13 Richard A. Smith, PhD.

61. Amini MH, Azar FM, Wilson BR, Smith R, Mauck BM, Throckmorton TW. Comparison of

Outcomes and Costs of Tension-Band and Locking-Plate Osteosynthesis in Transverse Olecranon

Fractures: A Matched-Cohort Study. Am J Orthop (Belle Mead NJ). 2015 Jul;44(7):E211-5. PMID:

26161765

62. Konofaos P1, Petersen D, Jennings JA, Smith RA, Doty H, Reves BT, Guda T, Appleford MR,

Bumgardner JD, Wallace RD. Evaluation of Amniotic Multipotential Tissue Matrix (AmnioMTM®) to

augment healing of Demineralized Bone Matrix (DBM) in a rat calvarial model. Journal of Craniofacial

Surgery, June 2015, 26(4),1408-12 PMID: 26080207

63. Biggers, M, Mauck, BM, Smith, R, Azar, FM, & Throckmorton, TW. Analysis of mechanical

failures after anatomic acromioclavicular joint reconstruction. Curr Orthop Prac Sept/Oct 2015, 26(5):

526-529

64. Azzam MG, Thockmorton TW, Smith RA, Graham D, Scholler J, Azar FM The Functional

Movement Screen as a Predictor of Injury in Professional Basketball Players Curr Orthop Prac. 2015

Nov/Dec;26(6):619-623.

65. Calandruccio JH, Cannon TA, Wodowski AJ, Stephens BF, Smith RA. A Mechanical & Histologic

Comparative Study of the Effect of Saline, Steroid, Autologous Blood, & PRP on Collagenase-Induced

Tendinopathy in a Rat Model Curr Orthop Prac.. Nov/Dec 2015;26(6)

66. Franklin BS, Smith RA, Beaty JH, Spence DD, Kelly DM, Sawyer JR, Warner WC. Early Career

Experience of Pediatric Orthopaedic Fellows: What to Expect & Need for Their Service J Pediatr

Orthop. 2015 Mar 3 [Epub ahead of print] PMID: 25851674

67. Walters JD, Barkoh K, Smith RA, Azar FM, Throckmorton TW. Younger patients report similar

activity levels to older patients after reverse total shoulder arthroplasty. J Shoulder Elbow Surg. 2016

Sep;25(9):1418-24 PMID: 27038566

68. Mohapatra A, Morshed BI, Haggard WO, Smith RA. A Brief Review of Stealth Engineering for in

vivo Drug Delivery Systems Crit Rev Biomed Eng. 2015;43(5-6):347-69. Review. PMID: 27480580

69. Jew NB, Hollins AM, Mauck BM, Smith RA, Azar Fm, Miller RH, Throckmorton TW Reliability

Testing of the Larsen and Sharp Classifications for Rheumatoid Arthritis of the Elbow J Shoulder Elbow

Surg. 2017 Jan;26(1):140-143. doi: 10.1016/j.jse.2016.07.074. Epub 2016 Oct 7. PMID: 27727050

70. Roberson TA, Throckmorton TW, Miller RH, Smith RA, Azar FM: Neurovascular injuries in acute

knee dislocations: a retrospective review of initial vascular evaluation using a selective angiography

algorithm Current Orthopaedic Practice. 27(5):508-514, September/October 2016.

71. Weller WJ, Azzam MG, Smith RA, Azar FM, Throckmorton TW. Liposomal bupivacaine mixture

has similar pain relief and significantly fewer complications at less cost compared to indwelling

interscalene catheter in total shoulder arthroplasty. J Arthroplasty. 2017 Nov;32(11):3557-3562 PMID

28390888.

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Curriculum Vitae Page 14 Richard A. Smith, PhD.

72. Ford MC, Brolin TJ, Meehan EM, Smith R, Azar FM, Throckmorton TW. Two-year clinical &

radiographic outcomes of a total shoulder arthroplasty utilizing a hybrid glenoid component with a

central porous titanium post. June 2017 Techniques in Shoulder and Elbow Surgery 18(2):72-76

73. Wells DB, Holt AM, Smith RA, Brolin TJ, Azar FM, Throckmorton TW. Tobacco Use Predicts a

More Difficult Episode of Care After Anatomic Total Shoulder Arthroplasty. J Shoulder Elbow Surg.

2018 Jan;27(1):23-28. doi:10.1016/j.jse.2017.06.033. Epub 2017 Jul 24. PMID: 28747276

74. Hopkins CM, Azar FM, Smith RA, Throckmorton TW: Scapular Notching in Revision Reverse

Total Shoulder Arthroplasty Tech Should and Elbow Surgery: June 2018 Vol 19(2) p 55-58

75. Nelson CG, Brolin TJ, Ford MC, Smith RA, Azar FM, Throckmorton TW. Five-year minimum

clinical and radiographic outcomes of total shoulder arthroplasty using a hybrid glenoid component with

a central porous titanium post. J Shoulder Elbow Surg. 2018 Mar 8. pii: S1058-2746(18)30057-0. doi:

10.1016/j.jse.2018.01.012. [Epub ahead of print] PMID:29526600

76. Kirk M Thompson, MD; Justin D Hallock, MD; Richard A Smith, PhD; Tyler J Brolin, MD;

Frederick M Azar, MD; Thomas W. Throckmorton, MDPre-operative narcotic use is associated with

markedly inferior outcomes after anatomic total shoulder arthroplasty: A clinical and radiographic

analysis Accepted by Journal of the American Academy of Orthopaedic Surgeons August 2017

77. Kirk M. Thompson · Tyler J. Brolin · Richard A. Smith · Frederick M. Azar · Thomas W. (Quin)

Throckmorton Liposomal Bupivacaine Mixture Has Similar Pain Relief and Significantly Fewer

Complications at Less Cost Compared to Indwelling Interscalene Catheter in Total Elbow Arthroplasty

Journal of Shoulder and Elbow Surgery 27(4):e126-e127 Apr 2018

78. Franklin DB, Stephens BF, Sawyer JR, M. Kelly DM, H. Beaty JH, Spence DA, Smith RA, Warner

W The evolving state of acute pediatric septic arthritis and osteomyelitis. Current Orthopaedic Practice.

29(3):209-213, May/June 2018.

79. Bills CC, Amini MH, Sykes JB, Bonnaig NS, Smith RA, Mauck BM, Miller RH, Azar FM.

Thomas W. Throckmorton Evaluation of Glenohumeral Rheumatoid Arthritis: Classification,

Reliability, and Impact on Surgical Management Techniques in Shoulder and Elbow Surgery 19(1):8-12

March 2018

Postoperative use of the wheeled knee walker after foot and ankle surgery (FAI-17-0556) Under Review

for Foot & Ankle International.

Ryan B Eads, MD; Tyler J Brolin, MD; Richard A Smith,

PhD; Frederick M Azar, MD; Thomas W Throckmorton, MD Mood disorders are associated with

inferior outcomes of anatomic total shoulder arthroplasty" Under Review for International Orthopaedics

Not Peer Reviewed Publications: Calandruccio, JH, Cannon TA, Wodowski, AJ, Stephens, BF, Smith RA. A Mechanical and Histologic

Comparative Study of the Effect of Saline, Steroid, Autologous Blood, and Platelet-Rich Plasma on

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Curriculum Vitae Page 15 Richard A. Smith, PhD.

Collagenase-Induced Achilles Tendinopathy in a Rat Model, Campbell Orthopaedic Journal, 2015, 1,

69-74.

Azzam MG., Throckmorton TW, Smith RA, Graham D, Scholler J, Azar FM. Functional Movement

Screen as a predictor of injury in professional basketball Players Campbell Orthopaedic Journal,

2015,1,15-19 Walters JD, Barkoh K, Smith RA, Azar FM, Throckmorton TW. Comparison of Outcomes of Reverse

Total Shoulder Arthroplasty in Patients Younger than 65 Years to Those in Patients Older than 65 Years

Campbell Orthopaedic Journal 2016 vol 2 55-56

Bills CC, Amini MH, Sykes JB, Bonnaig NS, Smith RA, Mauck BM, Miller RH, Azar FM.

Thomas W. Throckmorton, Reliability Testing for Three Classifications of

Glenohumeral Rheumatoid Arthritis Campbell Orthopaedic Journal 2016 vol 2 64-65

Nicholas B Jew MD, Anthony Hollins MD, Benjamin M Mauck MD, Richard A Smith PhD, Fred M

Azar MD, Robert H Miller MD, Thomas W Throckmorton MD Reliability testing of the Larsen and

Sharp classifications for rheumatoid arthritis of the elbow Campbell Orthopaedic Journal 2017,

Vol(3):27-30

Wells DB, Holt AM, Smith RA, Brolin TJ, Azar FM, Throckmorton TW Tobacco Use Predicts A

More Difficult Episode of Care After Anatomic Total Shoulder Arthroplasty Campbell Orthopaedic

Journal 2018, Vol(4):46-51

Peer-reviewed scientific presentations including from the last 10 years:

68. Smith, Richard; Selektor, Yelena; Maghsoodpour, Anobel; Green, Kelly; Bhattacharya, Syamal K.;

Weber, Karl T. Effects of Salbutamol and Spironolactone on ALDOST Induced Osteopenia in Rats

Transactions of the 54th Annual Meeting Orthopaedic Research Society, Vol.33 #0972 2008

69. Smith, RA; Walters, Brian; Emerson, Patrick; Crockarell, John; Lawrence, Robert; Crockarell,

John; Crenshaw, Andrew; Harkess, James Role of Endotoxin in Osteolysis and Possible Predisposition

to the Disease Toll-Like Receptor SNPs, and Monocyte Response With Osteolysis Transactions of the

54th Annual Meeting Orthopaedic Research Society, Vol.34, Las Vegas, NV, 2009 2378

70. Smith, RA; Maghsoodpour, A;. Hallab, Nadim J. In vivo response to cross-linked polyethylene and

polycarbonate urethane particles Transactions of the 54th Annual Meeting Orthopaedic Research

Society, Vol.34 # 2009

71. Smith, RA; Berry, SC; Cho, H; Huang, J; Hasty, KA Effects Of Platelet-Rich Plasma On Pig

Derived Annulus Fibrosus Chondrocyte Transactions of the 55th Annual Meeting Orthopaedic Research

Society, Vol.35 2010

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Curriculum Vitae Page 16 Richard A. Smith, PhD.

72. Smith, Richard; Allen, Brooke; Hauser, Spenser. In vitro Macrophage response to cross-linked and

conventional polyethylene particles Orthopaedic Transactions Vol. 36, Long Beach, CA, 2011 0379 -

Osteolysis; Inflammation; Cytokines; Implant Wear

73. Huang, Jinsong; Jha, Ribhu Tushar; Conoley, Jack; Cannon, Tyler; Maghsoodpour, Anobel; Azar,

Frederick; Smith, Richard; Hasty, Karen. Enhanced Bony Integration of An Engrafted Tendon In A Rat

Orthopaedic Transactions Vol. 36, Long Beach, CA, 2011 0947 - Model Ligament and Tendon Biology;

Bioactive Biomaterials

74. Jennings, Jessica A.; Hartdegen, Vernon; Bumgardner, Joel D.; Haggard, Warren O.; Smith,

Richard. Preliminary Characterization of Drilled Fracture Fixation Implant Particles In Vitro and In

Vivo Orthopaedic Transactions Vol. 36, Long Beach, CA, 2011 1317 - Bioinert Biomaterials; Fracture

Fixation; Inflammation

75. Smith, Richard; Marlar, Justin; Hauser, Spenser; Allen, Brooke; Nishimoto, Ken. The mechanism

of osteocalcin control of energy metabolism Orthopaedic Transactions Vol. 36, Long Beach, CA, 2011

#2306

76. Hall J, Miller R, Conoley J, Martinez S, Hyden J, Avila J, Smith R, Azar FA, Throckmorton TW.

Accuracy and reliability testing of two methods for measuring internal rotation of the glenohumeral

joint. Tennessee Orthopaedic Society, 2011.

77. Alexander T, Smith R, Azar FA, Throckmorton TW. The effect of humeral rotation on elbow range

of motion measurements. Tennessee Orthopaedic Society, 2011.

78. Cusick M, Smith R, Azar FA, Throckmorton TW. Accuracy and reliability testing of the Mayo

Elbow Performance Score. Tennessee Orthopaedic Society, 2011.

79. Calandruccio JH, Cannon TA, Smith RA, Stephens B, Caughran AT, Wodowski JA, Timmerman J

Comparative efficacy of autologous blood and platelet rich plasma in treating tendinopathy American

Society Surgery of the Hand Vegas September 2011.

80. Smith, RA; Chavez, B.; Brewer, K; Poole, NM; Coons, LB; Cole, JA Effects of Tick Saliva on

Musculoskeletal Inflammatory Molecules Orthopaedic Transactions Vol. 37, San Francisco, CA, 2012

1907 – Infection and Inflammation.

81. Smith, RA; Shackelford, H; Pestina, T; Persons, DA; Gartner, TK; Bone loss and structural changes

in a sickle cell disease mouse model Orthopaedic Transactions Vol. 37, San Francisco, CA, 2012 0552 -

Bone - Osteoporosis & Metabolic Bone Disease

82. Cusick M, Smith R, Azar FA, Throckmorton TW. Accuracy and reliability testing of the Mayo

Elbow Performance Score. Accepted to Mid-American Orthopaedic Association meeting, 2012.

83. Robert Murphy, David Richardson, Thomas W. Throckmorton, Fred Azar, Richard Smith, James

Beaty

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Curriculum Vitae Page 17 Richard A. Smith, PhD.

“PGY-1 Orthopaedic Surgery Residents: rotation and educational experience during the internship year”

selected for oral presentation at the 2012 OREF/ORS Southeast Region Resident Research Symposium.

84. Hall J, Miller R, Conoley J, Martinez S, Hyden J, Avila J, Smith R, Azar FA, Throckmorton TW.

Accuracy and reliability testing of two methods for measuring internal rotation of the glenohumeral

joint. Mid-American Orthopaedic Association meeting, 2012.

85. Sykes JB, Grear BJ, Amini MH, Smith R, Azar FM, Throckmorton TW. Comparison of one- versus

two-incision surgical techniques for distal biceps tendon ruptures: A matched cohort study. ORS/OREF

resident research symposium, 2012.

86. Monica Zugravu; Richard Smith; Benjamin Reves; Jessica Jennings; Jared Cooper; Warren

Haggard; Joel Bumgardner Physical Properties and In Vitro Evaluation of Collagen-Chitosan-Calcium

Phosphate Microparticle-Based Scaffolds for Bone Tissue Regeneration Orthopaedic Transactions Vol.

38, San Antonio, TX, 2013 POSTER #: 0768

87. B Reves, P Konofaos, D Petersen, R Wallace, R Smith, T Guda, M Appleford, WO Haggard, JA

Jennings, JD Bumgardner Bone Regenerative Capacity of rhBMP-2 Loaded Carboxymethylchitosan

Microspheres in a Rat Calvarial Defect

Presented at Society for Biomaterials 2013

88. Nina M. Poole, Gayatri Mamidanna, Richard A. Smith, Lewis B. Coons and Judith A. Cole:

Prostaglandin E2 in tick saliva regulates host cell migration and cytokine profile Presented at

Experimental Biology 2013

89. Marcus Biggers, Benjamin Mauck, Frederick Azar, Richard Smith, Thomas Throckmorton: Analysis

of mechanical failures after anatomic acromioclavicular joint reconstruction Presented at ACJR 2013

90. Michael Amini, Thomas Throckmorton, Fred Azar, Ben Mauck, Stephen Olson, Josh Sykes, and

Richard Smith: Reliability Testing Of Two Classification Systems For Elbow Osteoarthritis And Post-

traumatic Arthritis, Clinical Orthopaedic Society 2013

91. Hall J, Miller R, Conoley J, Martinez S, Hyden J, Avila J, Smith R, Azar FA, Throckmorton TW.

Accuracy and reliability testing of two methods for measuring internal rotation of the glenohumeral

joint. AAOS general meeting, 2013.

92. Amini M, Azar FM, Smith R, Throckmorton TW. Comparison of tension band versus plate

osteosynthesis in transverse olecranon fractures: A matched cohort study. Mid-American Orthopaedic

Association annual meeting, 2013.

93. Amini MH, Sykes JB, Olson ST, Mauck BM, Smith R, Azar FM, Throckmorton TW. Reliability

testing of two classification systems for elbow osteoarthritis and post-traumatic arthritis. Tennessee

Orthopaedic Society, 2013.

94. Azzam MG, Throckmorton TW, Rose J, Smith R, Azar FM. The Functional Movement Screen as a

predictor of injury in professional basketball players. Tennessee Orthopaedic Society, 2013

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Curriculum Vitae Page 18 Richard A. Smith, PhD.

95. Amini MH, Throckmorton TW, Smith R, Azar FM. Comparison of outcomes and costs of tension

band versus plate osteosynthesis in transverse olecranon fractures: A matched cohort study. Clinical

Orthopaedic Society annual meeting, 2013

96. Troy Roberson, Thomas Throckmorton, Fred Azar, Richard Smith: Neurovascular injuries in

extremely obese patients with acute knee dislocations: a retrospective review of initial vascular

evaluation and selective angiography” Clinical Orthopaedic Society 2013

97. Thomas Throckmorton, Michael Amini, Richard Smith, and Frederick Azar: Comparison of

Outcomes and Costs of Tension Band vs. Plate Osteosynthesis in Transverse Olecranon Fractures: A

Matched Cohort Study 2013 Closed Meeting of the American Shoulder and Elbow Surgeons

98. Marcus Biggers, Benjamin Mauck, Frederick Azar, Richard Smith, and Thomas Throckmorton:

Analysis of mechanical failures after anatomic acromioclavicular joint reconstruction Accepted for

American Shoulder and Elbow Surgeons Specialty Day Meeting 2014

99. William Mihalko, Lev Djenderedjian, Paramjeet S. Cheema, and Richard Smith: Effects of Gelsolin

on Macrophage Inflammatory Responses to Implant Wear Debris 60th Annual Meeting of the

Orthopaedic Research Society 2014

100. Mike Azzam, Thomas Throckmorton, Fred Azar, and Richard Smith: The Functional Movement

Screen as a Predictor of Injury in Professional Basketball Players 32nd Annual Meeting Mid-America

Orthopaedic Association 2014

101. Jennings J, Reves B, Smith R, et al.. In Vivo Evaluation of STRUCSURETM CP for Augmentation

of Segmental Defect Healing Society for Biomaterials 2014 Annual Meeting and Exposition. Denver,

CO. 2014

102. Byron F. Stephens, MD; Keith D. Williams, MD; Richard A. Smith, PhD The Clinical Utility of

MRI for Cervical Spine Evaluation and Clearance Following Blunt Trauma North American Spine

Society Oct. 2014

103. Biggers M, Mauck BM, Smith R, Azar FM, Throckmorton TW. Analysis of mechanical failures

after anatomic acromioclavicular joint reconstruction. AAOS annual meeting, 2014

104. Ford MC, Meehan EM, Smith R, Azar FM, Throckmorton TW. Two-year Clinical & Radiographic

Outcomes of a Total Shoulder Arthroplasty Utilizing a Hybrid Glenoid Componenet With a Central

Porous Titanium Post. Accepted to Mid-American Orthopaedic Association, 2015

105. Biggers M, Mauck BM, Smith R, Azar FM, Throckmorton TW. Analysis of mechanical failures

after anatomic acromioclavicular joint reconstruction. AAOS annual meeting, 2014.

106. Murphy RF, Azar FM, Mauck BM, Smith R, Throckmorton TW. Accuracy testing of four physical

examination maneuvers for detecting lateral epicondylitis. Mid-American Orthopaedic Association

meeting, 2014

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Curriculum Vitae Page 19 Richard A. Smith, PhD.

107. Kelly DM, Stephens B, Franklin D, Smith R. The Evolving State of Acute Pediatric Septic

Arthritis & Osteomyelitis EPOS, 2015 April 15-18; France

108. W. Mihalko, C. Xie, P. Cheema, R. Smith Macrophage Cytokine Release in Response to Gelsolin

in the Presence of Titanium Particles Orthopaedic Research Society 2015

109. Kelly DM, Smith RA, Hollins, Owen, Giles, Moisan, Sawyer JR, Warner WC, Spencer DD.

Characterization of collision sports injuries in children & adolescents Alabama Ortho Society Meeting,

April 2015; Sandestin

110. Hopkins CM, Azar FA, Smith RA. Scapular notching in revision RTSA Tennessee Orthopeadic

Society, Nashville, Sept. 26, 2015

111. Franklin, B. Stephens, Richard Smith, JHB, DDS, DMK, JRS, WCW Early Career Experience of

Pediatric Orthopaedic Fellows: What to Expect & Need for Their Service POSNA, April 29-May 2,

2015, Atlanta, GA

112. Weller WJ, Azzam MG, Smith RA, Azar FM, Throckmorton TW. Liposomal bupivacaine versus

indwelling interscalene catheter. Tennessee Orthopaedic Society, 2015.

113. Smith RA, Poplar L, Ryan Tomlinson R. PGE₂ Mitigates Macrophage Inflammatory Cytokine

Response to Particles Orthopaedic Research Society 2016 annual meeting

114. Hopkins CM, Azar FM, Mulligan RP, Hollins AH, Smith RA, Throckmorton TW. Computed

tomography and magnetic resonance imaging are equally reliable in the assessment of glenohumeral

arthritis and glenoid version. Mid-American Orthopaedic Association, 2016.

115. Hopkins CM, Azar FM, Smith RA, Throckmorton TW. Scapular notching in revision reverse total

shoulder arthroplasty. Mid-American Orthopaedic Association, 2016.

116. Weller WJ, Azzam MG, Smith RA, Azar FM, Throckmorton TW. Liposomal bupivacaine: Equal

pain relief and less complication versus interscalene block in shoulder arthroplasty. AAOS annual

meeting, 2016 paper 090

117. Hopkins CM, Azar FM, Mulligan RP, Hollins AH, Smith RA, Throckmorton TW. Computed

tomography and magnetic resonance imaging are equally reliable in the assessment of glenohumeral

arthritis and glenoid version. AAOS annual meeting, 2016 paper 330

118. Jordan Walters, MD, Kaku Barkoh, MD, Richard Smith, PhD, Frederick Azar, MD, Thomas

Throckmorton, MD Younger Patients Report Similar Activity Levels As Older Patients Following

Reverse Total Shoulder Arthroplasty", AAOS annual meeting, 2016

119. Weller WJ, Azzam MG, Smith RA, Azar FM, Throckmorton TW Liposomal Bupivacaine: Equal

Pain Relief and Less Complication versus Interscalene Block in Shoulder Arthroplasty 2016 AAOS

120. Jew N, Throckmorton WT, Azar FM, Hollins, BMM, RHM, Smith RA Reliability testing of the

Page 20: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 20 Richard A. Smith, PhD.

Larsen & Sharp classification systems for RA of the elbow Mid-American Orthopaedic Association,

2016

121. Weller WJ, Azzam MG, Smith RA, Azar FM, Throckmorton TW. Liposomal bupivacaine: Equal

pain relief and less complication versus interscalene block in shoulder arthroplasty. Accepted to Mid-

American Orthopaedic Association, 2017.

122. Thompson KM, Hallock JD, Smith RA, Brolin TJ, Azar FM, Throckmorton TW. Pre-operative

narcotic use predicts markedly inferior outcomes following anatomic total shoulder arthroplasty.

Accepted to Mid-American Orthopaedic Association, 2017.

123. Thompson KM, Hallock JD, Smith RA, Brolin TJ, Azar FM, Throckmorton TW. Pre-operative

narcotic use predicts markedly inferior outcomes following anatomic total shoulder arthroplasty. AAOS

annual meeting, 2017.

124. Wells DB, Holt AM, Smith RA, Brolin TJ, Azar FM, Throckmorton TW. Tobacco use predicts a

more difficult episode of care after anatomic total shoulder arthroplasty. AAOS annual meeting, 2017.

125. Throckmorton TW, Thompson KM, Brolin TJ, Smith RA, Azar FM, Liposomal Bupivacaine

Mixture Has Similar Pain Relief And Significantly Fewer Complications At Less Cost Compared To

Indwelling Interscalene Catheter In Total Elbow Arthroplasty Annual Meeting of the American

Shoulder and Elbow Surgeons, paper #14, 10/13/2017

126. Jane C. Yeoh MD, David J. Ruta MD, G. Andrew Murphy MD, David R. Richardson MD, Susan

N. Ishikawa MD, Benjamin J. Grear MD, Clayton B. Bettin MD, Richard A. Smith PhD Post-Operative

Use of the Wheeled Knee-Walker after Foot and Ankle Surgery, 2018 COA/CORS Annual Meeting

Committee Abstract ID Number: 463

127. Luke Tidwell, Anita Kerkhof, Richard A. Smith, Stephen Chambers, William M. Mihalko, Is

Topical TXA as Effective in Cemented and Press Fit Primary TKA? Orthopaedic Research Society

2018 Annual Meeting

128. Ryan Carpenetti; Barbara D. Smith; Josh Paschall; Joel D. Bumgardner; Richard Smith, The Impact

of Raspberry Ketone on Human Macrophages in Culture Orthopaedic Research Society 2018 Annual

Meeting

Submitted:

B. Minden-Birkenmaier, R. Smith, M. Z. Radic, G. L. Bowlin Modulating Neutrophil Response with

Manuka Honey, Neutrophil Symposium

Does The Transfusion Rate Following Reverse Total Shoulder Arthroplasty Warrant Aggressive Peri-

Operative Blood Management?: An Indications-Based Analysis.'

ASES 2018 Annual Meeting.

Pulmonary Comorbidities Are Associated With Increased Major Complication Rates Following

Indwelling Interscalene Nerve Catheters For Shoulder Arthroplasty'

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Curriculum Vitae Page 21 Richard A. Smith, PhD.

ASES 2018 Annual Meeting.

Does the Transfusion Rate Following Reverse Total Shoulder Arthroplasty Warrant Aggressive Blood

Management?" 2019 American Academy of Orthopaedic Surgeons Annual Meeting number 406

26 Research Presentations (not peer reviewed) including:

Bobby Lawrence; Luciana P. Schwab, Richard Smith Polymorphisms in macrophage’s endotoxin

receptors may predispose patients to peri-implant osteolysis Christian Brother’s University 11th Annual

Student Research Presentations 2007 *Dominic Dunn Award for Research

Berry, SC and Smith, R. Effects of platelet-rich plasma on pig derived annulus fibrosus chondrocyte

proliferation J Tn Acad Sci., Vol 83 (3-4) pages 68-71, 2008

Walter, B and Smith R. Monocyte Response in Osteolysis and Possible Predisposition to the Disease J

Tn Acad Sci., 2009

Maghsoodpour, Anobel, Richard Smith In vivo response to cross-linked polyethylene and polycarbonate

urethane particles Memphis BioImaing Symposium at the University of Memphis November 5-6, 2009

Allen, Brooke and Smith, Richard. In vitro macrophage response to titanium particles J Tn Acad Sci.,

2010

Kathleen Nelson, and Richard Smith. Determination of vitamin-d analogs for treatment of autoimmune

diseases without calcemic side effects J Tn Acad Sci., 2011 *1st award for presentation

Jonathan Timmerman and Richard Smith Comparative efficacy of autologous blood and platelet rich

plasma in treating tendinopathy. Tennessee Academy of Sciences 2012

http://www.cbu.edu/~aross/biodept/TAS2012/TAS2012.html

Jared Cooper M.S., Joel Bumgardner, Ph.D., John Williams, Ph.D., Judith Cole, Ph.D., Richard Smith,

Ph.D., Warren Haggard, Ph.D., " Scaffold Selection for Tendon/Bone Interface Tissue Engineering."

Graduate Research Forum. University of Memphis. Apr 2012.

Lekeisha E. Poplar, Richard Smith, Ph.D Title: “Effect on Cytokine Production of Varying Concentrations of PGE2 on Macrophages Stimulated

with Titanium Particles” 2015 UTHSC RESEARCH AND DEVELOPMENT SEMINAR

Ryan Tomlinson, Smith RA PGE2 mediates macrophage inflammatory cytokine response. Tennessee

Academy of Science April 2016

Christopher M. Hopkins MD, Frederick M. Azar MD, Ryan M. Mulligan MD, Anthony M. Hollins

MD, Richard M. Smith PhD, Thomas W. Throckmorton MD Computed tomography and magnetic

resonance imaging are similarly reliable in the assessment of glenohumeral arthritis and glenoid version

Campbell Orthopaedic Journal 2017, Vol(3):25-26

Page 22: CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. · CURRICULUM VITAE Richard A. Smith, B.S., M.S., Ph.D. EDUCATION: Memphis State University, B.S., 1979 Biology, Major: Vertebrate

Curriculum Vitae Page 22 Richard A. Smith, PhD.

William J Weller, MD, Michael G Azzam, MD, Richard Smith, PHD, Frederick Azar, MD, Thomas W

Throckmorton, MD Liposomal bupivacaine has equivalent pain relief and significantly fewer

complications at less cost compared to indwelling interscalene catheter in total shoulder arthroplasty

Campbell Orthopaedic Journal 2017, Vol(3):36-38

Yeoh JC, Ruta DJ, Murphy GA, Richardson DR, Ishikawa SN, Grear BJ, Bettin CB, Smith RA Post-

Operative Use of the Knee-Walker after Foot and Ankle Surgery: A Retrospective Study Campbell

Orthopaedic Journal 2017, Vol(3):48-49

Hopkins CM, Azar FM, Smith RA, Throckmorton TW Scapular Notching in Revision Total Shoulder

Arthroplasty Campbell Orthopaedic Journal 2017, Vol(3):80-81

Acott TR, Brolin TJ, Azar FM, Smith RA, Throckmorton TW A Quantitative Analysis of Deltoid

Lengthening on Associated Complications following Reverse Total Shoulder Arthroplasty Campbell

Orthopaedic Journal 2018, Vol(4):33-34

Lonergan TM, Villarreal AD, Smith RA, Brolin TJ, Azar FM, Throckmorton TW Mood Disorders Do

Not Predict A More Difficult Post-Operative Course Following Primary Total Shoulder Arthroplasty

Campbell Orthopaedic Journal 2018, Vol(4):41-42

Moore RA, Brolin TJ, Smith RA, Azar FM, Throckmorton TW Mood Disorders Do Not Have An

Adverse Effect On Outcomes Following Revision Total Shoulder Arthroplasty Campbell Orthopaedic

Journal 2018, Vol(4):44-45

Chambers JS, Tidwell L, Kerkhof A, Smith RA, Mihalko WM Is Topical TXA Effective in Hybrid

Fixation Total Knee Arthroplasty? Campbell Orthopaedic Journal 2018, Vol(4):55-56

Campion C, Olinger C, Gardocki RJ, Smith RA Ninety-Day Readmission and Complication Rate After

Minimally Invasive Transforaminal Lumbar Interbody Fusions Campbell Orthopaedic Journal 2018,

Vol(4):71