Curriculum vitae - CNPEMpages.cnpem.br/nmtrypi/wp-content/uploads/sites/49/... · Overview Edit CV Anabela Cordeiro Silva End session Overview 1. Personal data Full Name Anabela Cordeiro

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Overview Edit CV

A nabela C ordeiro Silva

End sess ion

Overview

1. Personal data

Full Name

Anabela Cordeiro Silva

Name under which you publish

Anabela Cordeiro-da-Silva

Fiscal ID number

1780837734

ID document

7295884

Birth date

02-09-1966

National of

Portugal

Gender

F

Work address

IBMC e Faculdade de Farmácia da Universidade do PortoRua Campo Alegre, 8234150-180 PortoPortugal

Residential Address

Rua Nova do Regado, 74, 4ºEsq4250 325Portugal

Work Phone

00351966125015

Residential Phone

00351226074923/49

Email

[email protected]

Fax

00351351 226 099 157

Cell phone

00351966125015

URL

www.ibmc.up.pt

2. Academic degrees

Year: 1989

Degree: LICENCIATURA

Final grade: 15 values

Degree granting institution Universidade do Porto

School/College/Campus Faculdade de Farmácia

Thesis title Degree in Pharmaceutical Sciences - Analysis Biological Chemistry

Supervisor:

Curriculum vitae

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Co-supervisor:

Scientific area Ciencias da Saude

Number of curricular years 6

Program title Degree in Pharmaceutical Sciences - Analysis Biological Chemistry

Year: 1992

Degree: MESTRADO

Final grade: Very good by unanimously


School/College/Campus Instituto de Ciências Biomédicas Abel Salazar

Thesis title Clonagem e sequenciação do cDNA que codifica

Supervisor: Maria de Sousa

Co-supervisor: André Capron



Program title Immunology Master

Year: 1995

Degree: LICENCIATURA




Thesis title Degree in Pharmaceutical Sciences - Pharmacy

Supervisor:

Co-supervisor:



Program title Degree in Pharmaceutical Sciences - Pharmacy

Year: 1993

Degree: Post-graduation course "Molecular Biology of the Immune System"

Final grade: Approved



Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1992

Degree: Post-graduation course in Molecular Biology of the Immune System.




Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1990

Degree: Post-graduation course in Medical Parasitology


Degree granting institution Universidade Nova de Lisboa

School/College/Campus Instituto de Higiene e Medicina Tropical

Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1990

Degree: Advanced course in Genetic Bacteriane


Degree granting institution Universidade de Lisboa


Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1989

Degree: Post-graduation course in Immunology




Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1996

Degree: FEBS International Summer School on Immunology. The Immune System: Genes,Receptors and Regulation


Degree granting institution FEBS

School/College/Campus n/a

Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1994

Degree: Post-graduation - Biologie de la cellule : modeles cellulaires


Degree granting institution École Doctorale du Museum, Universitée de Paris


Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1994

Degree: Course of “Interrogation des bases de donnée sur CD-ROM”


Degree granting institution Biblioteque Centrale de l’Institut Pasteur de Paris


Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1993

Degree: Post-graduation in “Radioprotection et de Prévention des Risques Professionnels”


Degree granting institution Secrétariat des Enseignements et des Stages de l’Institut Pasteur deParis


Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 1992

Degree: Post-graduation course in “Habilitation a l'utilisation du FACSCAN”


Degree granting institution Instituto Pasteur de Paris


Thesis title

Supervisor:

Co-supervisor:

Scientific area


Program title

Year: 2005

Degree: AGREGAÇÃO

Final grade: Approved unanimously



Thesis title

Supervisor:

Co-supervisor:

Scientific area Aggregation in Immunology

Program title

Year: 1997

Degree: DOUTORAMENTO

Final grade: Approved unanimously



Thesis title Ratinhos Balb.Xid: modelo de estudo dos mecanismos de resistência à infecção porTrypanosoma cruzi

Supervisor: Mário Arala Chaves

Co-supervisor: Paola Minoprio

Scientific area Imunologia

Program title Ciências Biomédicas - Immunologia

3. Previous activity and current status

Período Cargo, categoria ou actividade Instituição

01-7-2013a

IBMC BSL-3 Faciliteis Director IBMC

03-1-2011a

Responsible scientific service of "Cell Cultureand Genotyping" in IBMC.

IBMC

17-6-2012a

Deputy Director of the Unity of Infection andImmunity at IBMC

IBMC

a Head of the group Parsaite' disease Instituto de Biologia Molecular e Celular

a Associated Professor Faculdade de Farmácia da Universidade do Porto

a Member of Scientific CouncilInstitut de Recherche pour le Developpement,Montpellier, France.

a Responsable to the Animal facilities Faculdade de Farmácia da Universidade do Porto

aInvestigator recognized to use animals forexperiment or scientific assays

Direcção de Serviços e Meios de Defesa da Saúde,Bem Estar e Alimentação Animal Min. da Agricultura

a Member of Scientific SocietiesAmerican Society for Microbiology, membershipnumber 55683510, division B

a Member of Scientific Societies Sociedade Portuguesa de Ciências Farmacêuticas

a Member of Scientific Societies Sociedade Portuguesa de Bioquímica

a Member of Scientific Societies Société Francaise d’ Immunologie

a Member of Scientific Society Sociedade Portuguesa de Imunologia

aMember of Scientific Societies, membershipnumber 2724SO

The British Society for Parasitology

a Member of Profissional SocietiesOrdem dos Farmacêuticos (Sociedade FarmacêuticaLusitana)

a Member of Scientific Council Faculdade de Farmácia da Universidade do Porto

a Vice-President of Educational Council Faculdade de Farmácia, Universidade do Porto

a Vice-President of Educational Council Faculdade de Farmácia da Universidade do Porto

a Avaliator in Science Programme Junta Nacional de Investigação Ciêntífica. Lisboa

a Moderator in Scientific MeetingXXIX Annual meeting. Sociedade Portuguesa deImunologia. Porto

a Participation in Scientific Comitée MeetingVI Fórum Farmacêutico. Novas Terapias e TecnologiasFarmacêuticas

aParticipation in Scientific Comitée Meeting 1ºWorkshop de Bioquímica Clínica

Cupertino de Miranda Foundation, Porto

aParticipation to assess the fellowship of scientificinvestigation

Instituto de Biologia Molecular e Celular daUniversidade do Porto

aPresident to assess fellowship of scientificinvestigation

Unidade de Investigação de Stress em Animais doInstituto de Biologia Molecular e Celular

a Participation to assess Senior ResearcherInstituto de Biologia Molecular e Celular daUniversidade do Porto

aParticipation to assess fellowship of scientificinvestigation


aPresident to assess the fellowship scientificinvestigation

Faculdade de Farmácia da Universidade do Porto

aPresident to assess the fellowship in scientificinvestigation


a To assess a fellowship in scientific investigationInstituto de Biologia Molecular e Celular daUniversidade do Porto

aParticipation to assess the definitive inscriptionin PhD thesis of Isabel Alonso

Instituto de Ciências Biomédicas Abel Salazar daUniversidade do Porto

aParticipation to assess the definitive inscriptionin PhD thesis of Luisa Figueiredo

Instituto de Ciências Biomédicas Abel Salazar daUniversidade do Porto

aTo assess Researcher project in collaboration ofthe Industry

Agência de Inovação

aTo argue the PhD thesis “Etudeimmunopathologique de la maladie de Chagaschez la souris"

Université Pierre & Marie Curie, Paris

a Fellowship JNICT - Programa Ciência

a Fellowship SPI (Sociedade Portuguesa de Imunologia)

a FellowshipJNICT - Programa Planeamento e Projectos noInstituto Pasteur de Paris

a FellowshipJunta Nacional de Investigação Científica, Programade formação e mobilidade de recursos humanos

a FellowshipPrograma de cooperaçäo JNICT - Embaixada deFrança (Processo nº: 45400AC).

a Fellowship Fundação Calouste Gulbenkian

a FellowshipJunta Nacional de Investigação Científica eTecnologica(JNICT)/CentreNationaldeRechercheScientific

a Fellowship Fundação Calouste Gulbenkian

aTeaching post-graduation course Immunology tothe Chemists

Confederação dos Farmacêuticos do Norte(COFANOR)

aTalking in the meeting New Therapies andFramaceutical Technologies T

Fundação Eng. António de Almeida

a Teaching Post-graduation course inFarmacotherapy with the theme Vaccines

Associação Nacional Farmácias, Porto.

aTeaching Post-graduation: New vaccines inPediatrie

Associação Nacional Farmácias, Porto

aTeaching Post-graduation in LaboratorialDiagnosis inMedical Parasitology “Trypanosoma”

Serviço de Microbiologia da Faculdade de Medicina doPorto

a Teaching in post-graduation educationInstitut de Recherche pour le Développement,

Université de Montpellier I

aTeaching in the module of “ TheTrypanosomatids:Biology and importance”

Post Graduated in Basic and Applied Biology ofUniversidade do Porto

a Teaching in Control Quality Master Faculdade de Farmácia da Universidade do Porto

a Assistant Professor with definitive mention Faculdade de Farmácia da Universidade do Porto

a Assistant professor not definitive Faculdade de Farmácia da Universidade do Porto

aAssistant teacher in Immunology and MolecularGenetic

Faculdade de Farmácia, Universidade do Porto

aStudent teacher assistant in Immunology andMolecular Genetic

Faculdade de Farmácia, Universidade dom Porto

4. Area of scientific activity

Immunology: study of excretion / secretion trypanosomatids proteins involved in polyclonal activation of theimmune system responsible for infectivity of the body. Use of KO parasites, recombinant proteins, cDNA andgenes in dendritic cells as models of vaccines. Molecular Biology: Cloning and sequencing of genes encoding enzymes involved in drug targets and virulencefactors. Study of new drugs with anti-Leishmania. Using nanotechnology to increase the release of drugs andthe realization of new vaccine formulations.Diagnosis: Creating new methods of leishmaniasis diagnosis using the tools generated in the laboratory,namelly recombinant proteins.

5. Present research interest

Domain of specialization

Vaccines, Immunoparasitology, Drug target development.

Current research interests

Throughout the various ongoing projects, the key objective has been to find the components of the parasitethat are responsible for immune response. Molecules involved in parasite virulence factors as well assearching for possible targets of drugs, polyamine derivatives, as well as the identification of molecules of theparasite may be used as a marker of susceptibility or resistance to natural host (man or dog) forleishmaniasis. We have studied various drugs, some promising as already described for the treatment ofleishmaniasis. We are also interested in the use of KO parasites, recombinant proteins and dendritic cells as apromising model for vaccines. The use of nanotechnology in a controlled release of drugs or the use of newvaccine formulations is an area of recent interest.

Other professional interests/activities

Nanotechnology use to drug delivery systems, Nanodiagnosisis developmet, Host parasite interactions

6. Experience as scientific adviser

Carrier Development2013/2018 Carrier Development Joana Tavares. Trabalho intitulado: Dissecting the molecular basis ofPlasmodium sporozoites homing to the liver: a potential target to be considered in designing multi-antigenicmalaria vacines.

2008/2014 Ciência 2008 Ricardo Silvestre. Trabalho intitulado: “Molecular mecha-nisms regulating apoptosisof antigen presenting cells during visceral leishmaniasis: implication of sirtuin proteins”.

Post-Doc2012/ Supervisor of the post-Doc of Nuno Santarem. The work entitled: “Cell communication by Leishmaniamicrovesicles”

2011 Supervisor of the post-Doc of Walter Coura Vital . The work entitled: Imuno diagnostic of visceralleishmaniasis.Supported by Acções integradas Luso-Brasileiera, FCT-CAPES.

2010/2013 Supervisor of the post-Doc of Susana Sousa. The work entitled: Devel-opment of a newimmunological method for detection of leishmaniasis using colloidal gold nanoparticles. Fellowship numberSFRH/BPD/65214/2009.

2009 Supervisor of the post-Doc of Sandra Isabel Gomes Pereira. The work entitled: “Infecção porLeishmania infantum no modelo murino: influência do haplotipo H-2 na resposta imunológica celular”.Fellowship number SFRH/BPD/44990/2008.

2009/2012 Supervisor of the post-Doc of Joana Tavares. The work entitled Studying the human skin stage ofprotozoan parasites, implications to the disease outcome in co-supervision with Robert Menard, Unité deBiologie et Génétique du Paludisme, Institut Pasteur, France. Fellowship number SFRH/BPD/48340/2008.

2008/2009 Supervisor of the post-Doc of Ricardo Silvestre. The work entitled: Characterization ofHIV/Leishmania infantum co-infection in macrophage and dendritic cells: impact of apoptosis and immuneactivation in the disease development. Fellowship number SFRH/BPD/41476/2007.

2008/2013 Supervisor of the post-Doc of Sofia Costa Lima. The work entitled: De-velopment of BNIPpolyamine drug delivery systems, liposome and nanoparticles, to tar-get specially Leishmania infectedmacrophages and dendritic cells. Fellowship number BPD/37880/2007.

PhD

2013/….Co-supervisor of the PhD of Diana Raquel Bento Moreira, co-supervision with Ricardo Silvestre andJerome Estaquier. The work entitled: “Role of sirtuins in the con-text of host-pathogen interaction”in ParasiteDisease Group in Instituto de Biologia Molecular e Celular da Universidade do Porto and INSERM UMR 841 -Equipe 16, Faculté de Medicine, 8, França. Fellow FCT ref. SFRH/BD/91543/2012.

2013/… Supervisor of the PhD of Carla Patrícia da Silva Lima.The work entitled: “Current control measures ofleishmaniasis rely on early diagnosis and chemotherapy of dog reservoir suffering from this disease” inParasite Disease Group in Instituto de Biologia Molecular e Celular da Universidade do Porto.

2013/… Supervisor of the PhD of Renata Cardoso Belo da Costa, in co-supervision of Maria do Carmo Leite-de Moraes no Hôpital Necker, France. The work entitled: “Implication of iNKT cells on allergic inflammatoryresponses: role of microvesicles”. in Parasite Disease Group in Instituto de Biologia Molecular e Celular daUniversidade do Porto and Hôpi-tal Necker, France.

Universidade do Porto and Hôpi-tal Necker, France.

2012/ ….Supervisor of the PhD of Joana Raquel Correia Faria, in co-supervision of Lúcio Júnior. The workentitled: “ Ribose-5-Phosphate Isomerase and Asparagine Synthetase A targets specific small molecules tocontrol infections due to Trypanosomatids” is being developed in Portugal, in Parasite Disease Group inInstituto de Biologia Molecular e Celular da Universidade do Porto and Pasteur Institut of South korea.

2012/ ….Supervisor of the PhD of Luís Filipe Silva Gaspar, in co-supervision of Lúcio Júnior. The work entitled:“Targeting the Leishmania specific enzyme for the development of novel anti-parasitic strategies” is beingdeveloped in Portugal, in Parasite Disease Group in Instituto de Biologia Molecular e Celular da Universidadedo Porto and Pasteur Institut of South korea.

2009/ ….Supervisor of the PhD of Vasco Rodrigues, in co-supervision of Ricardo Silvestre e Jerome Estaquier.The work entitled: The role of sirtuins in the modulation of antigen presenting cell death during visceralleishmaniasis ” is being developed in Portugal, in Parasite Disease Group in Instituto de Biologia Molecular eCelular da Universidade do Porto and INSERM UMR 841 - Equipe 16, Faculté de Medicine, 8.

2009/ …. Supervisor of the PhD of Inês Loureiro, in co-supervision of Joana Tavares and Roy Nilanjan Roy.The work entitled: Target specific small molecules to control infections due to Trypanosomatids and theireffects on the immune system” ” is being developed in Portugal, in Parasite Disease Group in Instituto deBiologia Molecular e Celular da Universidade do Porto and Omics & Computational Biology Laboratory,National Institute of Pharmaceutical Education and Research, India.

2008/ …. Supervisor of the PhD of Joana Cunha, in co-supervision of Javier Moreno, Spain. The work intitled“Study of the immune response induced by a natural attenuated parasite compared to a virulent strain fromL. infantum in different animal models” is being developed in Portugal, in Parasdite Disease Group in Institutode Biologia Molecular e Celular da Universidade do Porto and Centro Nacional de Microbiologia- ISCIII inMajadahonda (Spain).

2007/2012 Supervisor of the PhD of Lúcia Teixeira, (fellowship of FCT, SFRH/BD/37178/2007 in co-supervision of Maria do Carmo Leite-de Moraes in Hôpital Necker, France. The work intitled "Role andmechanism of action of human immunoregulatory iNKT cells in Leishmania infection: new approaches forvaccination?" is being developed in Portugal, in Parasdite Disease Group in Instituto de Biologia Molecular eCelular da Universidade do Porto and Hôpital Necker, France. At present: Post-Doc at University of Minho,Portugal.

2007/2012 Supervisor of the PhD of Nuno Santarem(fellowship of FCT, SFRH/BD/37352/2007 in co-supervision of Marc Oullette in Laval University, Quebec, Canada. The work intitled "Study of the secretomeof Leishmania involved in infection" is being developed in Portugal, in Parasdite Disease Group in Instituto deBiologia Molecular e Celular da Universidade do Porto and Laval University, Canada. At present: Post-Doc atIBMC, Portugal.

2006/2012 Supervisor of the PhD of Marta Silva (fellowship of FCT, SFRH/BD/28316/2006 in co-supervision ofGrahm Coombs in University of Strathclyde, UK. The work intitled "The Leishmania TDR1 family-related gene:functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to protect againstleishmaniasis" is being developed in Portugal, in Parasdite Disease Group in Instituto de Biologia Molecular eCelular da Universidade do Porto and University of Strathclyde, UK. At present: Post-Doc at IBMC, Portugal.

2005/2009 Supervisor of the PhD of Liliana Mâncio da Silva (fellow from FCT, SFRH/BD/11756/2003) inconjunction with Artur Scherff, Instituto de Pasteur Paris, França. The work intitled “Epigenetic generegulation in the malária parasite P. falciparum” done in Portugal, in Serviço de Bioquímica da Faculdade deFarmácia da Universidade do Porto and in Instituto de Biologia Molecular e Celular da Universidade do Portoand in France, in Unit of “Interaction parasite hôte”, Institut Pasteur, Paris, France. At present: Post-Doc IMM,Portugal.

2004/2008 Supervisor of the PhD of Joana Alexandra Pinto da Costa Tavares (bolseira da FCT,SFRH/BD/18137/2004) in conjunction with Ali Ouaissi, do “Institut de Recherche pour le Développement,Montpellier”, France. The work intitled “ANTI-LEISHMANIAL DRUGS: study the role of novel polyaminederivative compounds for drug therapy and search for target specific SIR2 inhibitors” done in Portugal, inServiço de Bioquímica da Faculdade de Farmácia da Universidade do Porto and in France, in Institut deRecherche pour le Développement, Montpellier. January 2005 to January 2008. At present: Researcher atPasteur Institute in Paris, France.

2004/2007 Supervisor of the PhD of Ricardo Leal Silvestre (fellow of FCT, SFRH/BD/13120/2003) inconjunction with Ali Ouaissi, do “Institut de Recherche pour le Développement, Montpellier”, França. The workintitled “Leishmania SIR2 family-related gene: immunological studies and evaluation of SIR2 recombinantDNA and knockout vaccine to protect against Leishmaniasis”, done in Portugal, in Serviço de Bioquímica daFaculdade de Farmácia da Universidade do Porto and in Instituto de Biologia Molecular e Celular daUniversidade do Porto and in France, in Institut de Recherche pour le Développement, Montpellier. January2004 to January 2007. At present: Researcher Ciencia 2008, at IBMC, Portugal.

2003/... Colaboration in the experimental orientation of PhD thesis of Carmen Lisboa in Serviço deDermatologia do Hospital de São João, with work intitled: Male Candidiasis: more than just a sexuallytransmitted disease. Study of superantigens of Candida albicans in the scloritic genital liquid, is being studiedin Serviço de Bioquímica da Faculdade de Farmácia and in Instituto de Biologia Molecular e Celular daUniversidade do Porto. At present: Medical Assistant at HGSJ, Portugal.

2003/2008 Colaboration in the experimental orientation of PhD thesis of Olga M. F. Borges Ribeiro, assistantin Faculdade de Farmácia da Universidade de Coimbra, in Laboratório de Farmácia Galénica e TecnologiaFarmacêutica, with the theme: Coated nanoparticles as transport system of vaccines through the nasal andoral mucose. In particular, in co-supervision of the in vivo studies of the immunological responses in miceafter oral and nasal administration of coated nanoparticles transporter of the vaccine hepatitis B and inassessment of cytotoxicity of the nanoparticles referred to. At present: Assistant Professor at FFUC, Portugal.

2002/2007 Colaboration in the experimental orientation of PhD thesis of Sofia C. C. Lima of Faculdade deCiências da Universidade do Porto, with the work intitled Evaluation effect methal ion transition in drugtranspor by the P-glycoprotein, in the isolation of the glycoprotein Gp180 for use in liposomes as a drugtransporter. At present: Post-Doc at IBMC, Portugal.

1999/ 2003 Supervisor of the PhD of Margarida Coutinho Borges in conjunction with Ali Ouaissi, in Institut deRecherche pour le Développement, Montpellier, France. The work intitled Characterization of minimalfunctional domain of immunosupressor Tc52 protein of Trypanosoma cruzi with an eventual therapeuticapplication, done in Portugal, in Serviço de Bioquímica da Faculdade de Farmácia da Universidade do Portoand in Instituto de Biologia Molecular e Celular da Universidade do Porto and in France, in Institut deRecherche pour le Développement, Montpellier. Defended in 6 October of 2003 in Faculdade de Farmácia daUniversidade do Porto. At present: Assistent professor FFUP, Portugal.

MasterSupervisor of the Pharmaceutical Sciences of Vanessa Duarte. Work intitled: Lipossomas como Vetores deFármacos, Faculdade de Farmácia, Universidade do Porto.

2013 Supervisor of the Pharmaceutical Sciences of Fernando Toca. Work intitled: Malá-ria: epidemiologia,clinica e terapêutica. Mestrado de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade do Porto.

clinica e terapêutica. Mestrado de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade do Porto.

2012 Supervisor of the Pharmaceutical Sciences of Sílvia de Castro Morgado in co-supervision of CarmoLeite-de-Moraes, Faculté CNRS UMR 8147, Hôpital Necker, França. work intitled “Invariant NKT cells andnatural Th17 cells: Studies in pro-inflammatory conditions”. Faculdade de Farmácia, Universidade do Porto.

2012 Supervisor of the Cell Biology and Biotechnology master of Patrícia Varela Oliveira Martins. work intitled“Drug screening of Bisnaphthalimidopropyl derivatives on Trypanosoma brucei”. Faculdade de Ciências,Universidade de Lisboa.

2012 Supervisor of the Biochemistry master of Daniela Filipa dos Santos Barros. The work intitled“Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis”.Universidade do Porto.

2010/2013 Supervisor of Microbiology Master of Ana Luísa Robalo em co-tutela com Ricardo Sil-vestre. Thework intitled“Role of interleukin-12 cytokine family during visceral leishma-niasis”. Universidade Católica.

2010 Supervisor of the Instrumental Analytical Sciences Master, The Robert Gordon University, Aberdeen, UKof MARTA WOJTYNSKA. The work intitled “Nanotechnology approach in drug delivery systems for treatment ofleishaniasis” is being developed at Parasite Disease Group at IBMC.

2010 Supervisor of the Instrumental Analytical Sciences Master, The Robert Gordon University, Aberdeen, UKof Tariq Hassam. The work intitled “Evaluation of the in vitro biological effects of novel bis-naphthalimidopropyl polyamine derivatives in Leishmania infantum” is being developed at Parasite DiseaseGroup at IBMC.

2010 Supervisor of the MSc Pharmaceutical Sciences of Daniel Anthony Gonçalves Bispo . The work intitled“Phenotype of erythrocyte adhesion from Babesia divergens Bd37 protein” is being developed at Faculté dePharmacie, Université de Montpellier I”, France.

2010 Supervisor of the MSc Pharmaceutical Sciences of Carina Isabel Santos Alvané Gonçalves. The workintitled “iNKT cells and regulatory T cells in lenalidomide-treated myelodysplastic syndrome and multiplemyeloma patients” is being developed at Faculté of Medicine, CNRS UMR 8147, Hôpital Necker, France.

2010 Supervisor of the MSc Pharmaceutical Sciences of Luís Tiago André Coelho Morais . The work intitled“Selection and analysis of recombinant antibody from llama library against parasitic antigen” is beingdeveloped at Faculté de Pharmacie, Université de Montpellier I”, France.

2009/2010 Supervisor of the Analitic Toxicology and Forense MsC of Maria Helena Azevedo Teixeira deAndrade. The work intitled "Leishmania spp. Infection model optimization for drug discovery purposes" isbeing developed at Institute Pasteur da Coreia do Sul.

2009/ Supervisor of the MSc Pharmaceutical Sciences. Adelina de Jesus da Gama dos Santos. The workintitled “Sistema Imunológico: Autoimunidade” is being developed in Portugal, in FFUP da Universidade doPorto.

2009/2010 Supervisor of the MSc Pharmaceutical Sciences. Ivete Conceiçãoi Filipe Fernandes de Lima. Thework intitled “Crioglobulinas: avaliação clínica e laboratorial”. is being developed in Portugal, in FFUP daUniversidade do Porto.

2008/2009 Supervisor of the MsC of Vânia Filipa Esteves Vilas Boas, in co-supervision of Fernando Remião,Toxicology Departmente, FFUP. The work intitled “Determinação a expressão e actividade da glicoproteina-Pem linfócitos humanos” is being developed in Portugal, in Toxicology Department, FFUP da Universidade doPorto

2009 Supervisor of the MsC of Inês da Conceição Aleixo Ribeiro, Clinical Analysis Master, FFUP. The workintitled “Avaliation of the comportment of the recombinant protein CPX2 as a diagnosis marker andterapeuticalsucess in canin leishmaniasis”.

2009 Supervisor of the MsC Patricia Isabel Martins Gonçalves dos Santos, Clinical Analysis Master, FFUP. Thework entitled “Avaliation of incidence from monoclonal gammapathy in patients from Centro HospitalarTâmega e Sousa”.

2008/200 Supervision of Master in Biochemistry Universidade de Porto of Vasco Rodrigues . The work intitled“Macrophage targeted delivery of anti- Leishmania compounds using mannose coated poly(d,l-lactide-co-glycolide) nanoparticles ”, is being realized in Parasite Disease Group at Instituto de Biologia Molecular eCelular da Universidade do Porto. October 2008 until now.

2007/2008 Supervision of Master in Biochemistry Universidade de Porto of Mariana Resende. The workintitled “MODULATION OF DENDRITIC CELLS FUNCTION BY LEISHMANIA EXCRETED/SECRETED ANTIGENS”,is being realized in Parasite Disease Group at Instituto de Biologia Molecular e Celular da Universidade doPorto. Fevery 2007 to Dezember of 2005. Fellow integrated in a project.

2004/2006 Supervision of Master in Molecular Microbiology da Universidade de Aveiro of Joana Maciel. Thework intitled Study of the exreted/secreted parasite protein with immunological activity, is being realized inServiço de Bioquímica da Faculdade de Farmácia and in Instituto de Biologia Molecular e Celular daUniversidade do Porto. Fevery 2004 to September of 2005.

2004/2006 Co-supervision of Master in Molecular Microbiology da Universidade de Aveiro of Nuno Santarém.The work intitled Isolation of molecules involved in high-affinity iron uptake systems amastigote formes ofLeishmania infantum, is being realized in Serviço de Bioquímica da Faculdade de Farmácia and in Instituto deBiologia Molecular e Celular da Universidade do Porto. February of 2004 to September of 2005.

Orientation of fellowship holders of scientific investigation Mariana Resende, fellowship in scientific investigation in the project "PTDC/CVT/65047/2006 The LeishmaniaTDR1 family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockoutvaccine to protect against leishmaniasis"

Marisa Silva, fellowship in scientific investigation in the project "PTDC/CVT/65047/2006 The Leishmania TDR1family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine toprotect against leishmaniasis"

Inês Loureiro, fellowship in scientific investigation in the project “POCTI/SAU-CF/59837/2004 ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and searchfor target specific SIR2 inhibitors”

Joana Cunha, fellowship in scientific investigation in the project “POCTI/SAU-CF/59837/2004 ANTI-LEISHMANIAL DRUGS: study the role of novel polyamine derivative compounds for drug therapy and searchfor target specific SIR2 inhibitors”

Joana Costa, fellowship in scientific investigation in the project "PTDC/CVT/65047/2006 The Leishmania TDR1family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine to

family-related gene: functional studies and evaluated of TDR1 recombinant protein and knockout vaccine toprotect against leishmaniasis"

Augusta Sousa, fellowship in scientific investigation in the project "PTDC/SAU-FCF/67351/2006 ROLE OFDENDRITIC CELLS IN LEISHMANIASIS: intracellular signalling pathways activated by virulent and attenuatedparasite Leismania infantum.

Nuno Santarém, fellowship in scientific investigation in the project “ANTI-LEISHMANIAL DRUGS: study the roleof novel polyamine derivative compounds for drug therapy and search for target specific SIR2 inhibitors”.

Ana Marta Silva, fellowship in scientific investigation in the project “The Leishmania SIR2 family-related gene:functional studies and evaluation of SIR2 recombinant DNA and knockout vaccine to protect againstLeishmaniasis”.

Joana Maciel and Ana Marta Silva, fellowship in scientific investigation in the project “ Study of excreted /secreted proteins from Leishmania infantum with immunological activity".

Joana Tavares, fellowship in scientific investigation in the project nº14209;Clinical and immunological effectsof aminosidine therapy in dogs experimentally infected with Leishmania infantum.

Bruno Filipe Marques da Costa, fellowship in scientific investigation in the project 55082;Validation ofLeishmania infantum proteins as a immunodiagnostic marker.

Daniela Filipa Martins Duarte, fellowship in scientific investigation in the project 39257;Study ofexcretion/secretion of proteins induced by Leishmania infantum with immunological activity.

Ana Carvalho Figueiredo, fellowship in scientific investigation in the project 39257;Study ofexcretion/secretion of proteins induced by Leishmania infantum with immunological activity.

Nuno Santarém, fellowship in scientific investigation in the project 55082;Validation of Leishmania infantumproteins as a immunodiagnostic marker.

Natália da Costa Araújo, fellowship in scientific investigation in the Unit Stress in animals, in the Instituto deBiologia Molecular e Celular da Universidade do Porto, in the investigation project intitled: Study ofimmunological markers in Leishmaniasis treatment.

Carla Ferraz, fellowship in scientific investigation in the Unit Stress in animals, do Instituto de BiologiaMolecular e Celular da Universidade do Porto, in the investigation project intitled: Study of immunologicalmarkers to the Leishmaniasis treatment.

Margarida Coutinho Borges, fellowship in scientific investigation in the project Study of lymphocytepopulations involved in immunological response to ribosomal protein of 32 kDa of Leishmania major.

Raúl Bettencout, in his pós-graduate course in Biology, in Centro de Citologia Experimental, 22 of August of1989 to 22 September of 1989.

7. Participation in R&D projects

Participação em projectos de investigação (coordenador/membro de equipas)

As a principal investigator:Project (PTDC/BIA-MC/11866/2011) Cell communication by Leishmania microvesicles.FCT. 158 164€

NPP grant TRICONT, New INDIGO ERA NET: Science brings Europe and India closer, Target specific smallmolecules to control infections due to Trypanosomatics.

Project (PTDC/SAU-FCF/101017/2008) Role and mechanism of action of immunoregulatory iNKT and DC cellsin Leishmania infection: new approaches for vaccination? FCT

Project (PTDC/SAU-FCF/67351/2006) intitled "The Role of dendritic cells in leishmaniasis: intracellularsignalling pathways activated by virulent parasite Leishmania infantum" grant from Fundação para a Ciência eTecnologia (with assessment). 80.000euros

Project (PTDC/CVT/65047/2006) intitled "The Leishmania TDR1 family-related gene: functional studies andevaluated of TDR1 recombinant protein and knockout vaccines against leishmaniasis" grant from Fundaçãopara a Ciência e Tecnologia (with assessment). 168.241euros

Project (POCI/CVT//59840/2004) intitled “Leishmania SIR2 family-related gene: functional studies andevaluation of SIR2 recombinant DNA and knockout vaccine to protect against Leishmaniasis” grant fromFundação para a Ciência e Tecnologia (with assessment). 90.367euros

Project (POCTI/SAU-FCF/59837/2004) intitled“Molecular and functional characterization of the Leishmaniacytosolic SIR2 deacetylase and search for target specific SIR2 inhibiors” grant from Fundação para a Ciênciae Tecnologia (with assessment). 64.501euros

Project intitled New methods to diagnosis opportunist parasite (Leishmania) in immunodeficiency situations:by flow cytometry and by PCR-ELISA, submitted at Reitoria da Universidade do Porto/Fundação Ilídeo Pinho(without grant support). Project Ref. Nº: 55082 intitled Validation of Leishmania infantum proteins as aimmunodiagnosis marker, grant from Fundação Calouste Gulbenkian (with assessment).

Project (POCTI/CVT/14209/98/2001) intitled Clinical and immunological effects of aminosidine therapy indogs experimentally infected with Leishmania infantum grant from Fundação para a Ciência e Tecnologia(with assessment). 25.000euros

Project (POCTI/CVT/39257/2001) intitled Study of excretion/secretion proteins from Leishmania infantumwith immunological activity, grant from Fundação para a Ciência e Tecnologia (with assessment).80.000euros

Project Role of a Leishmania infantum mithocondrial tryparedoxin peroxidase as a proeminant immunogensubmitted to Fundação para a Ciência e Tecnologia (with assessment), not approved.

1999/2000. Project Study of lymphocyte populations involved in immunological response to ribosomal proteinof 32 kDa of Leishmania major, grant from Fundação Calouste Gulbenkian in Programa de Estímulo àIniciação Científica (with assessment). Project Study of immunological markers to the Leishmaniasistreatment, grant from Programa Plurianual da Fundação para a Ciência e Tecnologioa, in Unit of CellAdaptative Mechanisms, director Prof. Dr. Alexandre Quintanilha and co-director Prof. Dra. Natércia Teixeira(with assessment).

As colaborator:

Project PTDC/SAU-FCF/100749/2008: “Implication of sirtuin proteins in the regulation of antigen presentingcells apoptosis during leishmaniasis: a therapeutic approach”, PI:Ricardo Silvestre.

2007/2008 In the project intitled Development of remotely controlled multiparametric analytical systems -RECOMAS. Universidade do Porto-aixaGeral de Depositos. Pluridisciplinar.

2004-2006 In the project intitled “The cytosolic pathway for peroxide detoxification in Leishmania infantum:its importance for drug development and for parasite survival in macrophages” with Principal InvestigatorProf. Doutora Ana Tomás, grant from Fundação para a Ciência e Tecnologia (with assessment).

2002/2004 In the project (POCTI/CVT/34206/99) intitled Functional analysis of two trypanoredoxin moleculesof Leishmania infantum and their validation as drug targets, with Principal Investigator Prof. Doutora AnaTomás, grant from Fundação para a Ciência e Tecnologia (with assessment).

2003/2006 In the project (POCTI/ESP/41982/2001) intitled Isolation of molecules involved in high-affinity ironuptake systems of Leishmania infantum, with Principal Investigator Prof. Doutora Ana Tomás, grant fromFundação para a Ciência e Tecnologia (with assessment).

2002/2004 In the project (POCTI/CTA/47583/2002)intitled Phylogenetic characterisation of the parasitePerkinsus atlanticus by chromosome number and identification of conserved genes, with Principal InvestigatorProf. Doutor Carlos Azevedo, grant from Fundação para a Ciência e Tecnologia (with assessment).

1999/2001 In the project (Praxis/SAL/10263) intitled A Leishmania infantum mitochondrial peroxiredoxin:analysis of its role in parasite resistance to oxidative stress, with Principal Investigator Prof. Doutora AnaTomás, grant from Fundação para a Ciência e Tecnologia (with assessment).

1999 In the project intitled A Leishmania infantum mitochondrial peroxiredoxin: analysis of its role in parasiteresistance to oxidative stress with Principal Investigator Prof. Doutora Ana Tomás, submitted to UNDP/WorldBank/WHO: Organização Mundial de Saúde (with assessment). Not approved.

1993 In the project intitled Identification, clonning and sequencing of immunosupressive/B mitogenic factorsof Trypanosoma cruzi with Principal Investigator Prof. Doutor Mário Arala-Chaves, Laboratório de Imunologia,Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, grant from Junta Nacional deInvestigação Científica, Programa Stride.

1990 In the project intitled Tuberculosis and immuno modulation with Principal Investigator Dr. ManuelCasanovas, Serviço de Análises Clínicas do Hospital Militar de Doenças Infecto-Contagiosas, Lisboa. Octoberof 1989 to April of 1990.

1990 In the project intitled Screening of Fascioliasis in Benavente District with Principal Investigator Prof.Doutora Palmira Rombert, Serviço de Helmintologia, Instituto de Higiene e Medicina Tropical, Universidadenova de Lisboa. July of 1990.

1988/1989 In the project intitled Potential use of tritial in diets for Rainbow trout: effects of dietary levels andincidence of cooking with Principal Investigator Prof. Doutor Emídio Gomes, Laboratório de Fisiologia Animal,Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto.

International Responsible for the portuguese partner2013-2016 “Kinetoplastid Drug Development: strengthening the preclinical pipeline”. HEALTH.2013.2.3.4-2: Drugdevelopment for neglected parasitic diseases.FP7- HEALTH-2013-INNOVATION-1

2014-2017“New Medicines for Trypanosomatidic Infections”. HEALTH.2013.2.3.4-2: Drug development for neglected parasitic diseases.FP7- HEALTH-2013-INNOVATION-1

2014-2018“Clinical Studies on a Multivalent Vaccine for Human Visceral Leishmaniasis” HEALTH.2013.2.3.0-1: Innovationin vaccines. FP7-HEALTH-2013-INNOVATION-1.

2010-2011 IMMUNONET: Immunotherapy network. SOE1/P1/E014. União Europeia FP7. begin: 01-09-2010 End: 01-09-2012.

2010-2011 NPP grant TRICONT, New INDIGO ERA NET: Science brings Europe and India closer, Target specific smallmolecules to control infections due to Trypanosomatics. União Euro-peia FP7. begin: 01-09-2010 end: 01-09-2012.

2010 Project intitled: "Role and mechanism of action of human immunoregulatory iNKT cells in Leishmaniainfection: new approaches for vaccination?" Programa Pessoa. Embaixada de França and EGIDE.

2009/2010 Project intitled: “Diagnóstico imunológico da leishmaniose visceral”. Cooperação Cientifica eTecnológica FCT/CAPES – 2010-2011 (Proc.4.4.1.00 CAPES).

2009 Project intitled: "Role and mechanism of action of human immunoregulatory iNKT cells in Leishmaniainfection: new approaches for vaccination?" Programa Pessoa. Embaixada de França and EGIDE. 2400euros.

2008 Project intitled “The study into mode of action of novel polyamine derivatives /analogues as potentialantiparasitic therapeitics agents”. Acções Integradas Luso-Britânicas- 2008 NºB-10/08. 1500euros

2004/2005 Project intitled Role of protein SIR2 from Leishmania spp in the relationship parasite with host:Search a potential vaccine Project nº 706 C3 supported by the Programme GRICE / Embaixada de França(with assessment). Renovation for the second year.

2003/2004 Project intitled Role of protein SIR2 from Leishmania spp in the relationship parasite with host:Search a potential vaccine Project nº 706 C3 supported by the Programme GRICE / Embaixada de França(with assessment).

2002/...Project intitled The design, synthesis, mode of action and immunological study of novel antiparasiticpolyamine drugs in collaboration with Prof. Doutor Paul Kong, Gorden University, Aberdeen, UK.

1999 Project intitled Characterization of domain functional immunosupressor of Tc52 protein fromTrypanosoma cruzi. Project grant from Programa Científico e Técnico Luso-Francesa ICCTI-INSERM (withassessment).

Project intitled Immunological and molecular studies of the disease induced by Leishmania infantum andLeishmania major: immunological and molecular characterization of immunosupressive parasite components,cloning of the correspondent genes and assays of inactivation genes by the technic of genetic inverse. Projectgrant from Programa Científico e Técnico Luso-Francesa ICCTI-INSERM (with assessment).

grant from Programa Científico e Técnico Luso-Francesa ICCTI-INSERM (with assessment).

As a collaborator2003/2008 In the project intitled Mecanismes moléculaires et cellulaires de la pathogénie desTrypanosomatidae: corollaires épidémiologiques, physiopathologiques et immunoprophylactiques with aPrincipal Investigator Doutor Ali Ouaissi. Institut de Recherche pour le Développement, Montpellier, France.

1996 In the project intitled Role des populations cellulaires CD8+ dans la resistance à infection expermentalpar Trypanosoma cruzi with the Principal Investigator Doutora Paola Minoprio.

1992/1995 In the project intitled Development of a rational therapy for Chagas´cardiomyopathy withPrincipal Investigator Doutora Paola Minoprio, financiado pela Comunidade Europeia (ref. 921011),Département Immunologie Unité Immunophysiopathologie Infectieuse, Institut Pasteur de Paris, France.

1992/1994 In the project intitled Mutation Xid: modele etude immunobiologique et moleculaire des antigensinduteures de la resistance a la pathologie experimental de Chagas with Principal Investigator Doutora PaolaMinoprio, grant from TDR-World Health Organization, ID 910289. Laboratoire Immunoparasitologie de l´Institut Pasteur de Paris. 1 February of 1992 to 01 July of 1994.

1992/1993 In the project intitled Detection of profile Th1/Th2 in experimental infections with Trypanosomacruzi with Principal Investigator Doutora Paola Minoprio, Laboratoire Immunoparasitologie de l´ InstitutPasteur de Paris. July of 1992 to October of 1993.

8. Prizes and awards received

Year Name of the prize or award Promoting entity

2003 Scientific prize APDF 2003 Associação Portuguesa deDoutorados em França

1999 Gulbenkian Prize in the programmestimulus of scientific researcheinvestigator Fundação Calouste Gulbenkian

9. Published works

TesesCordeiro-da-Silva, A. Ratinhos Balb.Xid: modelo de estudo dos mecanismos de resistência à infecção porTrypanosoma cruzi. PhD thesis in Biomedical Sciences. Instituo de Ciências Biomédicas Abel Salazar,Universidade do Porto. 1997.

Cordeiro-da-Silva. A. Clonagem e sequênciação do cDNA que codifica para uma proteína de 16 kDa deSchistosoma mansoni. Master thesis in Immunology. Instituo de Ciências Biomédicas Abel Salazar,Universidade do Porto. 1992.

Cordeiro-da-Silva, A. Aggregation in Immunology. Faculdade de Farmácia, Universidade do Porto. 2005.

Capítulos de livros

Joana Cunha, Eugenia Carrillo, Javier Moreno and Anabela Cordeiro-da-Silva.Book chapitCan Attenuated Leishmania Induce Equally Effective Protection as Virulent Strains in Vis-ceralLeishmaniasis?. Capítulo do livro “Leishmaniasis” (In press).

Silvestre, R. and Cordeiro da Silva, A. Imunologia da Infecção. Capítulo do livro Fundamentos emImunologia, 2ªedição, 2012.

Cordeiro da Silva, A. Vacinas e Imunoterapia. Capítulo do livro Microbiologia Médica (in press), 2013.

Silvestre R, Santarém N, Tavares J, Silva AM and Cordeiro-da-Silva A. Recognition of Leishmania Parasitesby Innate Immunity. Immun., Endoc. & Metab. Agents in Med. Chem., 9, 001-0010, 2009.

Cordeiro-da-Silva, A., Lesmere, J.L., Sereno, D. and Ouaissi, A. Leishmaniasis: from infection toautoimmunity. Recent Research Developments in Immunology. 4:43-52. ISBN: 81-7736-142-2. 2002.

N. Santarém and A. Cordeiro-da-Silva. Diagnosis of visceral leishmaniasis. Communicating CurrentResearch and Educational Topicsand Trends in Applied Microbiology- 2007 Edition -

Artigos em revistas de circulação internacional com arbitragem científicaSantarém N, Cunha J, Silvestre R, Silva C, Moreira D, Ouellette M, Cordeiro-DA-Silva A. The impact ofdistinct culture media in Leishmania infantum biology and infectivity. Parasitology. 2013 Sep 6:1-14.

Sousa S, Cardoso L, Reed SG, Reis AB, Martins-Filho OA, Silvestre R, Cordeiro da Silva A. Development ofa fluorescent based immunosensor for the serodiagnosis of canine leishmaniasis combiningimmunomagnetic separation and flow cytometry. PLoS Negl Trop Dis. 2013 Aug 22;7(8):e2371. doi:10.1371/journal.pntd.0002371.

Lopes AP, Sousa S, Dubey JP, Ribeiro AJ, Silvestre R, Cotovio M, Schallig HD, Cardoso L, Cordeiro-da-SilvaA. Prevalence of antibodies to Leishmania infantum and Toxoplasma gondii in horses from the north ofPortugal. Parasit Vectors. 2013 Jun 17;6:178.

Resende M, Moreira D, Augusto J, Cunha J, Neves B, Cruz MT, Estaquier J, Cordeiro-da-Silva A, Silvestre R.Leishmania-infected MHC class IIhigh dendritic cells polarize CD4+ T cells toward a nonprotective T-bet+IFN-?+ IL-10+ phenotype. J Immunol. 2013 Jul 1;191(1):262-73.

Cunha J, Carrillo E, Sánchez C, Cruz I, Moreno J, Cordeiro-da-Silva A. Characterization of the biology andinfectivity of Leishmania infantum viscerotropic and dermotropic strains isolated from HIV+ and HIV-patients in the murine model of visceral leishmaniasis. Parasit Vectors. 2013 Apr 26;6:122. doi:10.1186/1756-3305-6-122.

Santarém N, Racine G, Silvestre R, Cordeiro-da-Silva A, Ouellette M. Exoproteome dy-namics in Leishmaniainfantum. J Proteomics. 2013 Jun 12;84:106-18. doi: 10.1016/j.jprot.2013.03.012. Epub 2013 Apr 1.

Ribeiro R, Monteiro C, Silvestre R, Castela A, Coutinho H, Fraga A, Príncipe P, Lobato C, Costa C, Cordeiro-da-Silva A, Lopes JM, Lopes C, Medeiros R.Human periprostatic white adipose tissue is rich in stromalprogenitor cells and a potential source of prostate tumor stroma. Exp Biol Med (Maywood). 2012 Oct1;237(10):1155-62.

Costa Lima SA, Resende M, Silvestre R, Tavares J, Ouaissi A, Lin PK, Cordeiro-da-Silva A.Characterizationand evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: in vitro and in vivo

studies. Nanomedicine (Lond). 2012 Dec;7(12):1839-49.

Mehdi O, Françoise S, Sofia CL, Urs G, Kevin Z, Bernard S, Igor S, Anabela CD, Dominique L, Eric M, Ali O.HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitorspanobinostat (LBH589) and trichostatine (TSA). Pan-creatology. 2012 Mar;12(2):146-55.

Silva AM, Tavares J, Silvestre R, Ouaissi A, Coombs GH, Cordeiro-da-Silva A. Charac-terization ofLeishmania infantum thiol-dependent reductase 1 and evaluation of its poten-tial to induce immuneprotection. Parasite Immunol. 2012 Jun;34(6):345-50.

Costa Lima S, Rodrigues V, Garrido J, Borges F, Kong Thoo Lin P, Cordeiro da Silva A. In vitro evaluation ofbisnaphthalimidopropyl derivatives loaded into pegylated nanoparti-cles against Leishmania infantumprotozoa. Int J Antimicrob Agents. 2012 May;39(5):424-30.

Moreira D, Santarém N, Loureiro I, Tavares J, Silva AM, Amorim AM, Ouaissi A, Cordeiro-da-Silva A,Silvestre R. Impact of continuous axenic cultivation in Leishmania infantum virulence. PLoS Negl Trop Dis.2012 Jan;6(1):e1469.

Silva AM, Cordeiro-da-Silva A, Coombs GH. Metabolic variation during development in culture of Leishmaniadonovani promastigotes. PLoS Negl Trop Dis. 2011 Dec;5(12):e1451.

Moreira-Teixeira L, Resende M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Dy M, Cordeiro-da-Silva A, Leite-de-Moraes MC. Rapamycin combined with TGF-ß converts human invariant NKT cells intosuppressive Foxp3+ regulatory cells. J Immunol. 2012 Jan 15;188(2):624-31.

Tavares J, Ouaissi A, Silva AM, Lin PK, Roy N, Cordeiro-da-Silva A. Anti-leishmanial activity of thebisnaphthalimidopropyl derivatives. Parasitol Int. 2012 Jun;61(2):360-3.

Vilas-Boas V, Silva R, Gaio AR, Martins AM, Lima SC, Cordeiro-da-Silva A, de Lourdes Bastos M, Remião F.P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expressionduring aging. Cytometry A. 2011 Nov;79(11):912-9.

Sousa S, Lopes AP, Cardoso L, Silvestre R, Schallig H, Reed SG, Cordeiro da Silva A. Seroepidemiologicalsurvey of Leishmania infantum infection in dogs from northeastern Portugal. Acta Trop. 2011 Oct-Nov;120(1-2):82-7.

Moreira-Teixeira L, Resende M, Coffre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,Ruemmele FM, Dy M, Cordeiro-da-Silva A, Leite-de-Moraes MC. Proinflammatory Environment Dictates theIL-17-Producing Capacity of Human Invariant NKT Cells. J Immunol. 2011 May 15;186(10):5758-65.

Silva R, Carmo H, Dinis-Oliveira R, Cordeiro-da-Silva A, Lima SC, Carvalho F, de Lourdes Bastos M,Remião F. In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells. Arch Toxicol. 2011 Apr;85(4):315-26.

Hoskins C, Ouaissi M, Lima SC, Cheng WP, Loureirio I, Mas E, Lombardo D, Cordeiro-da-Silva A, Ouaissi A,Kong Thoo Lin P. In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. Pharm Res. 2010 Dec;27(12):2694-703.

Neves BM, Silvestre R, Resende M, Ouaissi A, Cunha J, Tavares J, Loureiro I, Santarém N, Silva AM, LopesMC, Cruz MT, Cordeiro da Silva A. Activation of hosphatidylinositol 3-kinase/Akt and impairment of nuclearfactor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmaniainfantum-infected dendritic cells. Am J Pathol. 2010 Dec;177(6):2898-911.

Medhi Ouaissi, Sofia Cabral, Joana Tavares, Anabela Cordeiro-da-Silva, F. Mathieu Daude, E. Mas, JP.Bernard, B. Sastre, D. Lombard and Ali Ouaissi. Histone deacetylase (HDAC encoding gene expression inpancreatic câncer cell lines and cell sensitivity to HADAC inhibitors. Câncer Biology and Therapy. 20107:4:523-531.

Santarém N, Silvestre R, Cardoso L, Schallig H, Reed SG, Cordeiro-da-Silva A. Application of an improvedenzyme-linked immunosorbent assay method for serological diagnosis of canine leishmaniasis. J ClinMicrobiol. 2010 May;48(5):1866-74. Epub 2010 Feb 17.

Tavares J, Ouaissi A, Kong Thoo Lin P, Loureiro I, Kaur S, Roy N, Cordeiro-da-SilvaA.Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1. ChemMedChem.2010 Jan;5(1):140-7.

Silvestre R, Silva AM, Cordeiro-da-Silva A, Ouaissi A. The contribution of Toll-like receptor 2 to the innaterecognition of a Leishmania infantum silent information regulator 2 protein. Immunology. 2009Dec;128(4):484-99.

Silvestre R, Santarém N, Teixeira L, Cunha J, Schallig H, Cordeiro-da-Silva A. Evaluation of Leishmaniaspecies reactivity in human serologic diagnosis of leishmaniasis. Am J Trop Med Hyg. 2009 Aug;81(2):202-8.

Neves BM, Cruz MT, Francisco V, Garcia-Rodriguez C, Silvestre R, Cordeiro-da-Silva A, Dinis AM, BatistaMT, Duarte CB, Lopes MC.Differential roles of PI3-Kinase, MAPKs and NF-kappaB on the manipulation ofdendritic cell T(h)1/T(h)2 cytokine/chemokine polarizing profile. Mol Immunol. 2009 Aug;46(13):2481-92.

Nunes C, Sousa C, Ferreira H, Lucio M, Lima JL, Tavares J, Cordeiro-da-Silva A, Reis S.Substituted phenolsas pollutants that affect membrane fluidity. J Environ Biol. 2008 Sep;29(5):733-8.

Silvestre R, Santarém N, Cunha J, Cardoso L, Nieto J, Carrillo E, Moreno J, Cordeiro-da-Silva A. Serologicalevaluation of experimentally infected dogs by LicTXNPx-ELISA and amastigote-flow cytometry. VetParasitol. 2008 Nov 25;158(1-2):23-30.

Borges O, Silva M, de Sousa A, Borchard G, Junginger HE, Cordeiro-da-Silva A.Alginate coated chitosan nanoparticles are an effective subcutaneous adjuvant for hepatitis B surfaceantigen. Int Immunopharmacol. 2008 Dec 20;8(13-14):1773-80. Epub 2008 Sep 16.

Kadam RU, Tavares J, Kiran VM, Cordeiro A, Ouaissi A, Roy N. Structure function analysis of Leishmaniasirtuin: an ensemble of in silico and biochemical studies. Chem Biol Drug Des. 2008 May;71(5):501-6. Epub2008 Mar 27.

Lima SA, Cordeiro-da-Silva A, de Castro B, Gameiro P. Benzodiazepine-mediated structural changes in themultidrug transporter P-glycoprotein: an intrinsic fluorescence quenching analysis.J Membr Biol. 2008 Jun;223(3):117-25.

Tavares J, Ouaissi A, Santarém N, Sereno D, Vergnes B, Sampaio P, Cordeiro-da-Silva A. The Leishmaniainfantum cytosolic SIR2-related protein 1 (LiSIR2RP1) is an NAD+ -dependent deacetylase and ADP-ribosyltransferase. Biochem J. 2008 Nov 1;415(3):377-86.

Silvestre R, Cordeiro-da-Silva A, Ouaissi A. Live attenuated Leishmania vaccines: a potential strategicalternative. Arch Immunol Ther Exp (Warsz). 2008 Mar-Apr;56(2):123-6. Epub 2008 Mar 31. Review.

Borges O, Cordeiro-da-Silva A, Tavares J, Santarém N, de Sousa A, Borchard G, Junginger HE. Immuneresponse by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coatedchitosan nanoparticles. Eur J Pharm Biopharm. 2008 Jun;69(2):405-16. Epub 2008 Jan 31.

Cabral SM, Silvestre RL, Santarém NM, Tavares JC, Silva AF, Cordeiro-da-Silva A.A Leishmania infantumcytosolic tryparedoxin activates B cells to secrete interleukin-10 and specific immunoglobulin. Immunology.2008 Apr;123(4):555-65. Epub 2007 Nov 17.

Sousa C, Nunes C, Lúcio M, Ferreira H, Lima JL, Tavares J, Cordeiro-da-Silva A, Reis S. Effect ofnonsteroidal anti-inflammatory drugs on the cellular membrane fluidity. J Pharm Sci. 2008 Aug;97(8):3195-206.

Nunes C, Sousa C, Ferreira H, Lucio M, Lima JL, Tavares J, Cordeiro-da-Silva A, Reis S. Substituted phenolsas pollutants that affect membrane fluidity. J Environ Biol. 2008 Sep;29(5):733-8.13. Borges O, Tavares J, de Sousa A, Borchard G, Junginger HE, Cordeiro-da-Silva A. Evaluation of theimmune response following a short oral vaccination schedule with hepatitis B antigen encapsulated intoalginate-coated chitosan nanoparticles. Eur J Pharm Sci. 2007 Dec;32(4-5):278-90.

Leonor Teles-Grilo M, Duarte SM, Tato-Costa J, Gaspar-Maia A, Oliveira C, Rocha AA, Marques A, Cordeiro-da-Silva A, Azevedo C. Molecular karyotype analysis of Perkinsus atlanticus (Phylum Perkinsozoa) bypulsed field gel electrophoresis. Eur J Protistol. 2007 Nov;43(4):315-8.

Santarém N, Silvestre R, Tavares J, Silva M, Cabral S, Maciel J, Cordeiro-da-Silva A. Immune responseregulation by leishmania secreted and nonsecreted antigens. J Biomed Biotechnol. 2007;2007(6):85154.

Silvestre R, Cordeiro-Da-Silva A, Santarém N, Vergnes B, Sereno D, Ouaissi A. SIR2-deficient Leishmaniainfantum induces a defined IFN-gamma/IL-10 pattern that correlates with protection. J Immunol. 2007 Sep1;179(5):3161-70.

Oliveira J, Ralton L, Tavares J, Codeiro-da-Silva A, Bestwick CS, McPherson A, Thoo Lin PK. The synthesisand the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancercells and parasite Leishmania infantum. Bioorg Med Chem. 2007 Jan 1;15(1):541-5. Epub 2006 Sep 28.

Cardoso L, Schallig HD, Cordeiro-da-Silva A, Cabral M, Alunda JM, Rodrigues M. Anti-Leishmania humoraland cellular immune responses in naturally infected symptomatic and asymptomatic dogs. Vet ImmunolImmunopathol. 2007 May 15;117(1-2):35-41. Epub 2007 Jan 31.

Olga Borges, Gerrit Borchard, Adriano de Sousa, Hans E. Junginger and Anabela Cordeiro-da-Silva.Induction of lymphocytes activated marker CD69 following exposure to chitosan and alginate biopolymers.Int J Pharm. 2007 Jun 7; 337(1-2):254-64.

Adriano MA, Vergnes B, Poncet J, Mathieu-Daude F, da Silva AC, Ouaissi A, Sereno D. Proof of interactionbetween Leishmania SIR2RP1 deacetylase and chaperone HSP83. Parasitol Res. 2007 Mar;100(4):811-8.

Sereno D, Cordeiro da Silva A, Mathieu-Daude F, Ouaissi A. Advances and perspectives in Leishmania cellbased drug-screening procedures. Parasitol Int. . 2007 Mar;56(1):3-7. Epub 2006 Oct 31. Review.

Lima SA, Cordeiro-da-Silva A, de Castro B, Gameiro P. Sensitivity of P-glycoprotein tryptophan residues tobenzodiazepines and ATP interaction. Biophys Chem. 2007 Jan;125(1):143-50.

Sereno D, Vergnes B, Mathieu-Daude F, Cordeiro da Silva A, Ouaissi A. Looking for putative functions of theLeishmania cytosolic SIR2 deacetylase. Parasitol Res. 2006 Dec;100(1):1-9.

Borges O, Cordeiro-da-Silva A, Romeijn SG, Amidi M, de Sousa A, Borchard G, Junginger HE. Uptakestudies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles formucosal vaccination. J Control Release. 2006 Sep 12;114(3):348-58.

Silvestre R, Cordeiro-da-Silva A, Tavares J, Sereno D, Ouaissi A. Leishmania cytosolic silent informationregulatory protein 2 deacetylase induces murine B-cell differentiation and in vivo production of specificantibodies. Immunology. 2006 Dec;119(4):529-40.

Borges M, Cordeiro-da-Silva A, Vergnes B, Sereno D, Ouaissi A. Conversion of Trypanosoma cruzi Tc52released factor to a protein inducing apoptosis. Tissue Cell. 2005 Dec;37(6):469-78.

Vergnes B, Sereno D, Tavares J, Cordeiro-da-Silva A, Vanhile L, Madjidian-Sereno N, Depoix D, Monte-Alegre A, Ouaissi A. Target disruption of cytosolic SIR2 deacetylase discloses its essential role inLeishmania survival and proliferation. Gene. 19:85-96. 2005.

Lima, S.A., Cordeiro-da-Silva A., Gameiro, P. and Castro, B. A method for functional mouse MDR3 P-glycoprotein reconstitution in Escherichia coli lipids. Anal Biochem. 338: 350-353. 2005.

Ferreira, H., Lucio, M., Lima, J.L., Cordeiro-da-Silva, A., Tavares, J., Reis, S. Effect of anti-inflammatorydrugs on splenocyte membrane fluidity.Anal Biochem. 339: 144-149. 2005.

Tavares, J., Ouaissi, A., Lin, P.K.T., Tomás, A. and Cordeiro-da-Silva, A. Differential effects of polyaminederivative compounds against Leishmania infantum promastigotes and axenic amastigotes. Int. J.Parasitol.35:637-646. 2005.

Santarém,N., Tomás,A., Ouaissi, A., Tavares, J., Ferreira, N., Manso, A., Campino, L., Correia, J. M. andCordeiro-da-Silva, A - Antibodies against a Leishmania infantum peroxiredoxin as a possible marker fordiagnosis of visceral leishmaniasis and for monitoring the efficacy of treatment. Immunology Letters, 2005,101, 18-23.

Ouaissi, A., Ouaissi, M., Tavares, J. and Cordeiro-da-Silva, A. Host cell phenotypic variability induced byTrypanosomatid parasite released immunomodulatory factors: physiopathological implications. J. Biomed.Biotechnolog. 3: 167-174. 2004.

Castro, H., Sousa, C., Novais, M., Santos, M., Budde, H., Cordeiro-da-Silva, A., Flohé, L. and Tomás, A.Two close linked of Leishmania infantum encode tryparedoxins localized to the cytosol and to themitochondria. Mol. Biochem. Parasitol. 134: 137-147. 2004.

Cordeiro-da-Silva, A., Tavares, J., Santarém, N., Silvestre, R. and Ouaissi A. Antibodies against rLmS3aenhance the Leishmania uptake by murine peritoneal macrophages. Immunology 2004, ISBN88-7587-069-

1: 25-30. 2004.

Cordeiro-da-Silva, A., Tavares, J., Araújo, N., Cerqueira, F., Tomás, A., Thoo Lin, P.K. and Ouaissi A.Immunological alterations induced by polyamine derivatives on murine splenocytes and humanmononuclear cells. International Immunopharmacology, 4 : 547-556. 2004.

Cerqueira, F., Cordeiro-da-Silva, A., Gaspar, C., Simões, F., Pinto, M.M.M. and Nascimento, M. S. J. Effectof abietane diterpenes from Plectranthus grandilentatus on T- and B- lymphocyte proliferation. Bioorganic &Medicinal Chemistry. 12: 217-223. 2004.

Garzon, E., Borges, M.C., Cordeiro-da-Silva, A., Nacife, V., Meirelles, M.N., Guilvard, E., Bosseno, M.F.,Guevara, A.G., Breiner, S.F., Ouaissi, A. Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas’ disease in mice. Immunol Lett. Oct 9;89(1):67-80. 2003.

Cordeiro-da-Silva, A.*, Borges, M., Cardoso, L., Castro, H., Tomás, A., Rodrigues, M., Cabral, M. andOuaissi, A. Identification of antibodies to Leishmania silent information regulatory 2 (SIR2) proteinhomologue during canine natural infections: pathological implications. Immunol Lett. 86: 155-162. 2003.

Cerqueira, F., Cordeiro-da-Silva, A., Cidade, H., Kijjoa, A. and Nascimento, M. S. J. Inhibition oflymphocyte proliferation by prenylated flavones: Artelastin as a potent inhibitor. Life Science. 73: 2321-2334. 2003.

Borges, M., Cordeiro-da-Silva, A., Sereno, D. and Ouaissi, A. Peptide-based analysis of the amino acidsequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor.Immunology 109:147-155. 2003.

Cardoso, L., Santos, H., Cordeiro-da-Silva, A., Pratlong, F., Dedet J.P., Rodrigues, M.. Leishmania infantumMON-98: infection in a dog from the Alto Douro, Portugal. Acta Trop. Jul; 83(1):83-5. 2002.

Castro, H., Sousa, C., Santos, M., Cordeiro-da-Silva, A., Flohé, L. Tomás, A.M. Complementary antioxidantdefence by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum. Free Radic Biol Med.1;33(11):1552-62. 2002.

Cordeiro-da-Silva, A.*, Borges, M., Guilvard, E., and Ouaissi, A. Dual role of Leishmania major ribosomalprotein S3a homologue in the regulation of T and B cell activation. Infection & Immunity. 69: 6588-96.2001.

Santos-Lima, E.C., Vasconcellos, R., Reine-San-Martin, B., Fesel, C., Cordeiro-da-Silva, A., Berneman, A.,Cosson, A., Coutinho, A. and Minoprio, P. Significant association between the skewed natural antibodyrepertoire of Xid mice and resistance to Trypanosoma cruzi infections. Eur. J. Immunol, Feb; 31 (2): 634-45. 2001.

Borges, M., Guilvard, E., Cordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. EndogenousTrypanosoma cruzi Tc52 protein expression up regulates the growth of murine macrophages and fibroblastsand cytokine gene expression. Immunology Letters, 78:127-34. 2001.

Ouaissi, A., Cordeiro-da-Silva, A.*, Guevara, A., Borges, M. and Guilvard, E. Trypanosoma cruzi-inducedhost immune system dysfunction: a rationable for parasite immunosuppressive factor(s) encoding genetargeting. Journal of Biomedicine and Biotechnology, 1:11-17. 2001.

Guevara, A.G., Guilvard, E., Borges, M.M., Cordeiro-da-Silva, A., Ouaissi, A. N-Acetylcysteine andglutathione modulate the behaviour of Trypanosoma cruzi experimental infection. Immunol Lett, 71(2):79-83. 2000.

Reina-San-Martín, B., Degrave, W., Rougeot, C., Cosson, A., Chamond, N., Cordeiro-da-Silva, A., Arala-Chaves, M., Coutinho, A. and Minoprio, P. A B-cell mitogen from a pathogenic trypanosome is a eukaryoticproline racemase. Nature Medicine. 8: 890–897. 2000.

Zemzouni, K., Guilvard, E., Sereno, D., Preto, A., Benlemlih, M., Cordeiro-da-Silva, A., Lemesre, J.L. andOuaissi, A. Cloning of a Leishmania major gene encoding for an antigen with extensive homology toribosomal protein S3a. Gene. 240 (1): 57-65. 1999.

Cordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 kDa Trypanosomacruzi specific antigen as a B cell activater. Immunology. 94: 189-196. 1998.

Cordeiro-da-Silva, A., Santos Lima, E. and Minoprio, P. V?6 bearing T cells are involved in resistance toTrypanosoma cruzi infection in XID mice. International Immunology. 8: 1213-1219. 1996.

Cordeiro-da-Silva, A., Lepresle, T., Capron, A. and Pierce, R. Molecular cloning of a 16kDa Cu/Znsuperoxide dismutase from Schistosoma mansoni. Mol. Biochem. Parasitol. 52:275-278.1992.

Artigos em revistas nacionais com arbitragem científica1. Cordeiro-da-Silva A. Immune response in leishmaniasis induce s polyclonal activation. Review paper.Revista da Sociedade de Ciências Farmacêuticas. Submited

2. Santarém N, Fernandes F and Cordeiro-da-Silva A. Leishmaniasis diagnosis. Instituto de BiologiaMolecular e Celular News. 8. September. 2004.

3. Tavares J and Cordeiro-da-Silva A. The role of dendritic cells in Leishmania infection. Instituto deBiologia Molecular e Celular News. 8. September. 2004.

4. Silvestre R and Cordeiro-da-Silva A. The role of dendritic cells in Leishmania vaccina-tion. Instituto deBiologia Molecular e Celular News. 8. September. 2004.

5. Cordeiro-da-Silva A and Borges M. Leishmaniasis control by DNA vaccination. Insti-tuto de BiologiaMolecular e Celular News. 6. nº 8. September. 2002.

6. Cordeiro-da-Silva A. Leishmania spp induce infection or autoimmunity?. Instituto de Biologia Molecular eCelular News. 5.nº 8. September. 2001.

7. Cordeiro-da-Silva A. Entrevista a Anabela Cordeiro da Silva. Artigo de divulgação científica. Revista daOrdem dos Farmacêuticos. VII. Novembro/Dezembro. 58-59. 2000.

8. Zemzoumi K, Borges M, Guilvard E, Cordeiro-da-Silva A Ouaissi A. Determination of the minimalfunctional immunosuppressive domain of Tc 52 protein from Trypanosoma cruzi. Revista da SociedadePortuguesa de Imunologia. 5, 57-58. 1999.

9. Cordeiro-da-Silva A. Estudo molecular e imunológico da infecção por Trypanosoma cruzi. Artigo derevisão. Revista da Sociedade Portuguesa de Imunologia. 2, 11-35. 1997.

10. Cordeiro-da-Silva A, Carvalho F and Silveira I. Algumas notas sobre anti-depressivos Triciclicos. Rev.Port. Farm. Vol. XXXVII. 4: 137-142. 1987.

Publicações em actas de encontros científicosAnabela Cordeiro-da-Silva, Ana Marta Silva, Joana Tavares, Mariana Resende, Grahm Coombs. TDR1 elicitsa protective immune response in the contexto f infection for experimental leishmaniasis. InternationalImmunology, 2010, ISSN 0953-8178. PP-002-22.

Renata Silva, Anabela Cordeiro-da-Silva, Félix Carvalho, Maria de Lourdes Bastos, Helena Carmo,Fernando Remião. P-glycoprotein induction as a cellular protection tool against xenobiotics toxicity.Toxicology Letters 189S (2009) S57–S273.

M. Resende, R.silvestre, N.Santarém, S. G. Pereira, A. Cordeiro-da-Silva "Leishmania infantumexcreted/secreted molecules modify dendritic cells activation status". European Journal of Immunology,Supplement 1/09, ISSN 0014-2980, EJIMAF 39 (S1)-S808 (2009), Vol 39, No. S1, September 2009,PA11/58.

Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela Cordeiro-da-Silva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. 2009European Journal of Immunology, 39, S1: 107, PA13/22.

Bruno Neves, Ricardo Silvestre, Joana Cunha, Joana Tavares, Mariana Resende, Ali Ouaissi, Maria CelesteLopes, Maria Teresa Cruz and Anabela Cordeiro-da-Silva. Immunomodulation of dendritic cells by virulentand attenuated Leishmana infantum strains. European Journal of Immunology, 39, S1: 365, PA1/60. 2009

Mariana Resende, Ricardo Silvestre, Nuno Santarém, Sandra Gomes Pereira and Anabela Cordeiro-da-Silva. Leishmania infantum excreted / secreted molecules modify dendritc cells activation status. 2009Journal of Immunology, 39, S1: 365, PA1/58.

Santarém N, Silvestre R, Cardoso L, Cordeiro-da-Silva A (2007). Evaluation of enzyme-linkedimmunosorbent and flow cytometry assays for the serological diagnosis of visceral leishmaniasis usingcrude and recombinant Leishmania proteins. Proceedings, International Conference of the World Associationfor the Advancement of Veterinary Parasitology, Ghent, Belgium, p. 343.

Silvestre R, Santarém N, Cardoso L, Nieto J, Moreno J, A. Cordeiro-da-Silva A (2007). The potential of flowcytometry as a diagnostic technique for canine leishmaniasis. Proceedings, X Iberian Congress ofParasitology, Madrid, Spain, DVD.

Tavares, J., Lin, P.K.T. and Cordeiro-da-Silva, A. New polyamine derivative compounds active againstLeishmania infantum induce apoptosis-like-death. Revista Portuguesa de Farmácia. ISSN 0484-811X Vol. LII(n.º2) Suplemento. 61-62, 2005.

Tavares, J., Ouaissi, A., Thoo Lin,P.K. and Cordeiro da Silva, A.. New Polyamine Derivative CompoundsActive Against Leishmania infantum Expressing Stable Luciferase Activity Induce Apoptosis-like Death.Parassitologia. ISSN 0048-2951 Vol. 47, Suppl.1. 121, 2005.

Anabela Cordeiro-da-Silva, Joana PC Tavares, Nuno Santarém, Ricardo Silvestre and Ali Ouaissi. AntibodiesAgainst rLmS3arp Enhance the Leishmania Uptake by Murine Peritoneal Macrophages. Clinical InvestigativeMedicine. 2004. T45. 54.

Joana Tavares, Ali Ouaissi,Paul Kong Thoo Lin, Ana Tomás and Anabela Cordeiro-da-Silva. Apoptosis-likedeath of Leishmania infantum induced by polyamine derivate compounds. Clinical Investigative Medicine.2004. M4.64.

Lima, S.A.C., Cordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C., Gameiro, P. And Castro, B. Purificação da P-glicoproteína (MDR3) funcional a partir de células de Pichia pastoris. Revista Portuguesa de Farmácia. O-12,ISSN 0484. Vol.LII (1). 2003.

Araújo, N., Tavares, J., Borges, N., Santarém, N., Cordeiro-da-Silva, A. Modification of different cellpopulations during experimental Leishmania infantum infection. Revista Portuguesa de Farmácia. O-12,ISSN 0484. Vol.LII (1). 2003.

Garzón, E., Borges, M., Cordeiro-da-Silva, A., Guilvara, E., Bosseno, M. F., Guevara, A. G., Breaiére, S. F.and Ouaissi, A. Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicitsattenuated Chagas’ disease in mice. Infectiom, Genetics and Evolution. 2: 235. 2003.

Garzón, E., Nacife, V.P., Monte-Alegro, A., Cordeiro-da-Silva, A., Guilvara, E., Bosseno, M. F., Meirelles, M.N. L., Guevara, A. G., Borges, M., Breaiére, S. F. and Ouaissi, A. Trypanosoma cruzi carrying a targeteddeletion of a Tc52 protein-encoding allele elicits attenuated Chagas’ disease in mice. Rev. Inst. Med. Trop.S. Paulo. 45: 134. 2003.

Castro, H., Lopes, R.B., Cordeiro-da-Silva, A., and Tomás, A. A mithocondrial H2O2 detoxification pathwayin Leishmania infantum. Eur. J. Biochem. 268:233. 2001.

Cordeiro-da-Silva, A., Coutinho Borges, M. Guilvard, E. and Ouaissi, A. Leishmania major ribosomal proteinS3a induces a polyclonal B cell populations. Immunology Letters, vol. 73, nº2,3, 184. 2000.

Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. Determination of theimmunosupressive domain of Tc52 protein of Trypanosoma cruzi. Revista da Sociedade Portuguesa deImunologia. Ano 5. vol 1. 57. 1999.

Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. Caracterização funcional dodomínio imunossupressor da proteína Tc52 de Trypanosoma cruzi. Acta Parasitológica Portuguesa, vol. 5,nº2. 1998.

Cordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 kDa Trypanosomacruzi specific antigen as a B cell activater. Revista da Sociedade Portuguesa de Imunologia. 4, C22. 1996.

Cordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. Diguanosine tetraphosphate(Gp4G) activate a B cell population. Revista da Sociedade Portuguesa de Imunologia. 4,C23. 1996.

Cordeiro-da-Silva, A., E. C., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares CD8+ naresistencia à infecção experimental pelo Trypanosoma cruzi. Revista da Sociedade Portuguesa deImunologia. 2, C15. 1995.

Cordeiro da Silva, A., Santos Lima, E. C., Vicentelli, M. H. and Minoprio, P. - The resistance of Balb.XIDmice to Trypanosoma cruzi infection is associated to presence of Vb6 bearing T cells. XX Annual Meeting onBasic Research in Chagas´Disease. Memórias do Instituto Oswaldo Cruz. suppI.: 89, IM-023, 1994.

Parra, J., Cordeiro da Silva, A., Cumano, A., Minoprio, P., Kourilsky P. and Coutinho, A. - T cell repertoireactivated during acute phase of experimental T. cruzi infection. XX Annual Meeting on Basic Research in

Chagas´ Disease. Memórias do Instituto Oswaldo Cruz. suppl., 89, IM-015, 1994.

Cordeiro da Silva, A., Liegeard P., Arala Chaves, M. and Minoprio, P. - Identificaçäo of immunossupressive/ mitogenic factors of Trypanosoma cruzi. XX Annual Meeting on Basic Research in Chagas´Disease.Memórias do Instituto Oswaldo Cruz. suppl., 88, IM-7, 1993.

Cordeiro da Silva, A., Liegeard P., Tavares, D., Arala Chaves, M. and Minoprio, P. - Effect of P43immunossupressive/ B mitogenic factor of Candida albicans in the immunomodulation of Trypanosoma cruziinfection. XX Annual Meeting on Basic Research in Chagas´Disease. Memórias do Instituto Oswaldo Cruz.suppl., 88, IM-8, 1993.

Cordeiro da Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular modelto study antigens which induce resistance to murine Chagas´ Disease. XX Annual Meeting on BasicResearch in Chagas´ Disease. Memórias do Instituto Oswaldo Cruz. suppl., 88, IM-6, 1993.

Santos Lima, E., Cordeiro-da-Silva, A., Liegeard, P. and Minoprio, P. gd CD3 and CD5B lymphocytes play aconsistent role in the mechanisms leading to Chagas´ Disease pathology. XX Annual Meeting on BasicResearch in Chagas´ Disease. Memórias do Instituto Oswaldo Cruz. suppl.: 88, C-6. 1993.

Cordeiro da Silva, A., Le Presle, T., Capron, A., and Pierce R. - Cloning and characterization of a Cu/Znsuperoxide dismutase from Schistosoma mansoni. Molecular and Cellular Biology of Host-parasiteinteractions - Keyston Symposium. J. Cell. Biochem. Park City. January. 1992.

In Nacional Reviews

1. Lima, A.C., Cordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C., Gameiro, P. And Castro, B. Purificação da P-glicoproteína (MDR3) funcional a partir de células de Pichia pastoris. Revista Portuguesa de Farmácia. O-12,ISSN 0484. Vol.LII (1). 2003.

2. Araújo, N., Tavares, J., Borges, N., Santarém, N., Cordeiro-da-Silva, A. Modification of different cellpopulations during experimental Leishmania infantum infection. Revista Portuguesa de Farmácia. O-12,ISSN 0484. Vol.LII (1). 2003.

3. Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. Caracterização funcionaldo domínio imunossupressor da proteína Tc52 de Trypanosoma cruzi. Acta Parasitológica Portuguesa, vol.5, nº2. 1998.

4. Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. Determination of theimmunosupressive domain of Tc52 protein of Trypanosoma cruzi. Revista da Sociedade Portuguesa deImunologia. Ano 5. vol 1. 57. 1998.

5. Cordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 KdaTrypanosoma cruzi specific antigen as a B cell activater. Revista da Sociedade Portuguesa de Imunologia.4, C22. 1996.

6. Cordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. Diguanosine tetraphosphate(Gp4G) activate a B cell population. Revista da Sociedade Portuguesa de Imunologia. 4,C23. 1996.

7. Cordeiro-da-Silva, A., E. C., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares CD8+ naresistencia à infecção experimental pelo Trypanosoma cruzi. Revista da Sociedade Portuguesa deImunologia. 2, C15. 1995.

PatentesEuropean Patent nº 03/12689 in co-owner and co-invention of Universidade do Porto and “Institut deRecherche pour le Développement”. Title of invention: “Souches de protozoaires de virulence attenuée etleur utilisation“ 29 October of 2003.

International Patent Nº: PCT/IB07/52311 in co-owner and co-invention of Universidade do Porto and TheRobert Gordon University, Aberdeen, UK. Title of invention: NEW DERIVATIVES OFBISNAPHTHALIMIDOPROPYL, PROCESS FOR ITS PREPARATION,PHARMACEUTICAL FORMULATION AND ITSUSE IN LEISHMANIASIS, TRYPANOSOMIASIS AND MALARIA.

10. Communications in scientific meetings

Comunicações orais por conviteAnabela Cordeiro da Silva e Ricardo Silvestre. ESCMID Postgraduate Technical Workshop "TechnicalWorkshop for Basic and Clinical Parasitology. Leishmania: immunity. CIM – FMUP (Centro de InvestigaçãoMédica Faculdade de Medicina da Uni-versidade do Porto).

Anabela Cordeiro da Silva. ESCMID Postgraduate Technical Workshop "Technical Workshop for Basic andClinical Parasitology. Leishmania: diagnosis. CIM – FMUP (Centro de Investigação Médica Faculdade deMedicina da Universidade do Porto).

Cordeiro-da-Silva, A. (invited speaker) Leishmania infection modify innate imune cells to regulateadaptative immunity. How XXXVIII Annual Meeting of the Portuguese Society of Immunology. FromImmune Disorders to Immunotherapies. 25-27 November 2012.

Cordeiro-da-Silva, A. TRICONT: Target specific small molecules to control infections due toTrypanosomatids. New INDIGO NPP during the EU-India S&T Cooperation Days 2011 in Vienna on 1-2December 2011.

Cordeiro-da-Silva, A. Distinct immunological role of Leishmania infan-tum on infected and bystanderdendritic cells. 5th Meeting of the immunotherapy: New Trends in immunotherapy. Network (IMMUNONET).Madrid, Spain, 20, May 2011.

Cordeiro-da-Silva A. Convidada. “SIR2-deficient Leishmania in-fantum induces a cytokine profile thatcorrelates with protection”. BIT Life Sciences’ 3rd World Congress of Vaccine: Infectious, Imunity andVaccinology. 23-25 Mars, Bei-jing. Chine. 2011.

Cordeiro-da-Silva A. “Effect of bisnaphthalimidopropyl polyamine derivatives against experimentalLeishmania infantum infection by cytosolic SIR2 related protein 1”. 22 de Mars, Instituto Pasteur da Coreiado Sul, Seul. Coreia do Sul. 2011.

Cordeiro-da-Silva, A "Escape mechanisms devised by Parasites and Mycobacteria: possible interference"Conferênces Jacques Monod. Aussois, França. 1994.

Outras comunicações oraisInternational meetings

Anabela Cordeiro-da-Silva. The role of bisnaphthalimidopropyl derivatives to control trypanosomatidneglected infections. COST ACTION CM0801 4th ANNUAL MEETING Kolymvari, Crete 10-21th September

2012.

Cordeiro-da-Silva, A. (invited speaker). How Leismania infection modify innate immune cells to regulate adaptative immunity. SPI: From immune disorders to immunotherapies. 1-25-27 Novembro2012. XXXVIII SPI Annual Meeting. Porto.

Resende, M, Moreira, D, Cunha, J, Augusto, J, Neves B, Cruz, MT, Estaquier J, Cordeiro-da-Silva, A,Silvestre, R. Leishmania – infected mature dendritic cells polarize CD4+T cells towards a non-protective T-bet+ INF-gamma+ IL-10+ phenotype. EMBO/EMBL Symposium. New Perspectives on Immunity to Infec-tion. Heidelberg, Germany.19-22 May 2012.

Costa Lima S and Cordeiro-da-Silva A. The role of Amphotericin B in poly(lactic-co-glycolic acid) (PLGA)nanoparticles against visceral leishmaniasis. Joint Expert Meeting between Working Groups 1 and 3 of theCOST Action CM0801, Heidelberg, Holanda, 17-18 Mars. 2011.

Moreira-Teixeira L, Resende M, Coffre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,Ruemmele FM, Dy M, Cordeiro-da-Silva A, Leite-de-Moraes M C. World Immune Regulation Meeeting –VInnate and Adaptive Immune Response and Role of Tissues in Immune Regulation. 24-27 Mars, Davos,Suiça.2011.

Costa Lima S, Roussaki M, Sampaio S, Detsi A, Kefalas P and nabela Cordeiro-da-Silva. Heterocyclicscaffolds with anti - Leishmania infantum activity determined by flow cytometry. Joint Expert Meetingbetween Working Groups 1 and 3 of the COST Action CM0801, Siena, Italy, Mars. 2010.

Costa Lima S, Kong Thoo Lin P and Cordeiro da Silva A. Nanotechnology as a tool towards trypanosmiasisand leishmaniasis chemotherapies. Joint Expert Meeting between Working Groups 1 and 3 of the COSTAction CM0801, Siena, Italy, Mars. 2010.

Cordeiro da Silva A, Silvestre R, Santarem N, Cunha J, Cardoso L, Nieto J, Carrillo E and Moreno J.Serological evaluation of experimentally infected dogs by LicTXNPX-ELISA and amastigote-flow cytometry.Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801, Siena, Italy, Mars.2010.

Kong Thoo Lin P, Tavares J, Ouaissi A,Loureiro I, Kaur S, Roy N and Cordeiro da Silva A. NovelBisnaphthalimidopropyl Derivatoves as Inhibitors of Leishmania SIR2 Re-lated Protein 1. Joint ExpertMeeting between Working Groups 1 and 3 of the COST Ac-tion CM0801, Siena, Italy, Mars. 2010.

Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, OlivierHERMINE, Elke SCHNEIDER, Michel DY, Anabela CORDEIRO-DA-SILVA, and Maria C. LEITE-DE-MORAES.Foxp3-expressing human invariant NKT cells”. 4ème journée Scientifique Miltenyi Biotec: "Frominflammation to immunomodulation in cancer", 24 June 2010, Paris - France.

Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, OlivierHERMINE, Elke SCHNEIDER, Michel DY, Anabela CORDEIRO-DA-SILVA, and Maria C. LEITE-DE-MORAES.Foxp3-expressing human invariant NKT cells. 13e Colloque Cytokines du Crosic. French Societyfor Immunology - Presqu'île du Croisic, France. 10-12 Mai 2010.

Renata Silva, Anabela Cordeiro-da-Silva, Félix Carvalho, Maria de Lourdes Bastos, Helena Carmo,Fernando Remião. P-glycoprotein induction as a cellular protection tool against xenobiotics toxicity.EUROTOX: 26th Congress of the European Societies of Toxicology. September, 13-16, 2009, Dresden,Germany.

Joana Tavares, Sofia Costa Lima and Anabela Cordeiro da Silva. Effect of bisnaphthalimidopropylpolyamine derivatives against experimental Leishmania infantum infection by cytosolic SIR2 related protein1. Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801, Sófia, Bulgária, Maio.

Joana Tavares, Ana Marta Silva, Ali Ouaissi, Paul Kong Thoo Lin, Nilanjan Roy and Anabela Cordeiro daSilva. Antileishmanial activity of the bisnaphthalimidopropyl derivatives. 4th World Congress onLeishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India.

Sofia.A.C. Lima, Paul Kong and Anabela Cordeiro da Silva.Encapsulation of bisnaphthalimidopropylderivatives, two novel anti-Leishmania drugs, in biodegradable PLA and PLGA nanoparticles. Nanomedicine2008, Barcelona, Espanha, Setembro.

Ricardo Silvestre, Ali Ouaissi and Cordeiro-da-Silva, A. Leishmania cytosolic SIR2 deacetylase inducesselective murine B cell activation in vitro and in vivo. XI International Congress of Parasitology. 6-11August 2006. Glasgow,UK.

Silvestre R., Cordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Altered virulence of L. infantumSIR2 single knockout-mutant: evaluation of its potential use as a vaccine candidate. 16th EuropeanCongress of Immunology, September 6-9, 2006, Paris, France.

Nuno Santarém; Sandra Carvalho; Susana Romão; Anabela Cordeiro-da-Silva; Vítor Costa, Ana M Tomás.– Aquisição de Ferro em Amastigotas de Leishmania infantun, IX Congresso Ibérico de Parasitologia.Coimbra. 25 a 28 de Outubro de 2005.

Santarém, N; Cardoso, L.; Tomás, A.; Cordeiro-da-Silva, A. Flow Cytometry analysis as an alternativediagnostic method to canine Leishmaniasis. 9º Congresso da Sociedade Ibérica de Citometria. Porto. 19 a21 de Maio de 2005.

Borges, M., Cordeiro-da-Silva, A., Vergnes, S., Sereno, D. And Ouaissi, A The role of TC52 fromTrypanossoma cruzi: Apoptosis induction in cell populations. The first international conference. Mechanismsof cell death and disease: Advance in therapeutic intervention. Sintra, Portugal. 8 November of 2002 to 11November of 2002. C-2.

Castro, H., Sousa, C., Santos, M., Budde, H., Lunsdorf, H., Cordeiro-da-Silva, A., Flohé, L. and Tomás, AM.A mitochondrial peroxiredoxin in Leishmania infantum antioxidant defence. British Society for ParasitologyTrypanosomiasis and Leishmaniasis Seminar. Edinburgh, UK. 8 September of 2002 to 11 September of2002. Pag.53.

Borges, M., Cordeiro-da-Silva, A Sereno, D. and Ouaissi, A T. cruzi Tc52 derived synthetic peptidemediated suppression of IL-2 and IFN gamma production. Woods Hole Immunoparasitology Meeting.WoodsHole, Massachusetts, USA. 28 April of 2002 to 29 April of 2002. Pag. 15 # 15.

Castro, H., Lopes, R.B., Cordeiro-da-Silva, A. and Tomás, AM. The mitochondrial H2O2 detoxificationsystem of Leishmania infantum. 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Lisboa, Portugal, 6to 9 May of 2001. Pag. 53.

Castro, H., Cordeiro-da-Silva, A., Flohé, L. and Tomás, AM. Functional characterization of a putativemitochondrial peroxiredoxin from Leishmania infantum. 2nd International Meeting on Cellular Responses to

Oxidative and Osmotic Stress, Póvoa do Varzim, Portugal, 7 to 10 November of 2001. Pag.151.

Cordeiro-da-Silva, A., Coutinho Borges, M., Guilvard, E. and Ouaissi, A. Leishmania major RibosomalProtein Induce a Polyclonal B Cell Populations.14th European immunology Meeting, Poznan, Polonia, 23 to27 September of 2001.

Santos Lima, E., Cosson, A., Cordeiro-da-Silva, A., Pereira da Silva, L. and Minoprio, P. La résistance àTrypanosoma cruzi est dépendante de la regulation précoce d’INF-g et de TNF. Societe Francaise deParasitologie, Paris, France, 10 to 12 Mars of 1997.

Santos Lima, E., Cordeiro-da-Silva, A., Liegeard, P. and Minoprio, P. gd CD3 and CD5B lymphocytes play aconsistent role in the mechanisms leading to Chagas´ Disease pathology. XX Annual Meeting on BasicResearch in Chagas´ Disease. Caxambu, Brasil, 9 to 11 November of 1993. C6.

Cordeiro-da-Silva, A., Le Presle, T., Capron A. and Pierce R. - Cloning and characterization of a Cu/Znsuperoxide dismutase from Schistosoma mansoni. British Society for Parasitology. York, Inglaterra. April.1992. C12.

Castro, H, Sousa, C, Santos, M, Budde, H, Lunsdorf, H, Cordeiro da Silva, A, Flohé, L. & Tomás, AM. (2002).“Compartmented antioxidant defence by peroxiredoxins in Leishmania infantum”. 2nd InternationalSymposium on Antioxidants in Nutrition and Therapy: Mechanisms in Physiology-Pathology-Pharmacology,Out. 2-4, Bali, Indonesia.

National meetings

Anabela Cordeiro da Silva. Imunologia e Infeção: Resposta imunológica na leishmaniose. VI CongressoCientífico Anual NEF/AAC: Imunologia, Doenças Imunológicas e Imunote-rapias. Coimbra, 15 and 16November 2012.

Ricardo Silvestre e Anabela Cordeiro da Silva (invited speakers). Imunopatologia da leishmaniose visceral:conceitos e perspetivas futuras.Leishmaniose em Portugal no século XI. UTAD. 24 ofOctober 2011.

Santarem N, Cordeiro-da-Silva A, Ouellette M. Study of the exoproteome of Leishmania infantum. SecondI3S Scientific Retreat IBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Silva AM, Tavares J, Silvestre R, Ouaissi A, Coombs GH and Cordeiro-da-Silva A. Re-combinant ThiolDependent Reductase 1 from Leishmania infantum induces protection against Visceral Leishmaniasis.Second I3S Scientific Retreat IBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Bruno Neves, Ricardo Silvestre, Mariana Resende, Joana Cunha, Inês Loureiro, Joana Tavares, Ali Ouaissi,Maria Celeste Lopes, Maria Teresa Cruz and Anabela Cordeiro Silva. PI3 kinase/AKT activation andNF.kappa B impairment: a strategy used by Leishmabia parasites to impair DC function. XXXV AnnualMeeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.

Resende, M., Silvestre, R., Pereira, S and Cordeiro-da-Silva, A. Modulation of dendritic cells function byleishmania excreted/secreted proteins. XXXIV Annual Meeting of the Portuguese Society for Immunology,October, 26-28, 2008, Porto, Portugal.

Santarém N., Silvestre R., Tavares J., Cabral S., Silva M., and Cordeiro-da-Silva, A. Comparative study ofthe cytokine production in vitro and in vivo of three proteins involved in the trypanothione cascade. IISimpósio Nacional de Citocinas, May 8, 2006, Coimbra, Portugal.

Silvestre R., Cordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Attenuated SIR2-deficientLeishmania infantum as a vaccine candidate, XXXII Reunião Anual da Sociedade Portuguesa de Imunologia,October 13-14, 2006, Braga, Portugal

Anabela Cordeiro-da-Silva. Parâmetros Imunológicos em Toxicologia- uma ciência, várias vertentes.Fundação António de Almeida, Porto. 6 e 7 de Abril de 2005.

Santarém, N; Cardoso, L.; Tomás, A.; Cordeiro-da-Silva, A. Flow Cytometry analysis as an alternativediagnostic method to canine Leishmaniasis. 9º Congresso da Sociedade Ibérica de Citometria. Porto. 19th-21st May. 2005.

Tavares, J., Araújo, N., Silvestre, R., Borges, M., Ouaissi, A., Cordeiro-da-Silva, A. Antibodies againstrLmS3arp enhance the Leishmania uptake by murine peritoneal macrophages. XXIX Annual meeting.Chronic infections. Sociedade Portuguesa de Imunologia. Porto, Portugal, 9 to 11 October of 2003. C1.3.

Borges, M., Garzón, E., Cordeiro-da-Silva, A., Guilvard, E. And Ouaissi, A. Trypanosoma cruzi Tc52+/-mutant induced attenuated Chagas’ disease in mice. 2º Workshop Cell Adaptative Mechanisms. Ongoingwork and future perspectives. Vairão, Portugal, 12 June of 2003. Pag. 25.

Araújo, N., Tavares, J., Borges, M., Santarém, N. and Cordeiro-da-Silva, A. Modification of different cellpopulations during experimental Leishmania infantum infection. 1º Congresso da Sociedade Portuguesa deCiências Farmacêuticas. Lisboa, 14 to 16 April of 2002. O-12.

Cerqueira, F., Cordeiro-da-Silva, A., Gaspar, C., Simões, F. and Nascimento, M.S.J. A. 7a-Acetoxi-6b-hydroxyroyleanona: a potent inhibitor of T and B lymphocyte proliferation. XIII Congresso Nacional deBioquímica. Lisboa, Portugal, 5 to 7 Dezember of 2002. P5.

Araújo, N., Cerqueira, F., Tavares, J., Kong Thoon Lin, P. and Cordeiro-da-Silva, A. Polyamine derivatecompounds induce a immunossupressive effect on Leishmania host cells by an apoptotic mechanism.XXVIII Reunião Annual da Sociedade Portuguesa de Imunologia. Transplantação, tolerância e inflamação.Coimbra, 14 to 16 November of 2002. OP4.1.

Borges, M, Garzon, E., Cordeiro-da-Silva, A., Guilvard, E., Bosseno, MF, Guevara, AG, Breinere, S. AndOuaissi, A Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein encoding allele elicitsattenuated Chagas’ disease in mice. XXVIII Reunião Annual da Sociedade Portuguesa de Imunologia.Transplantação, tolerância e inflamação. Coimbra, 14 to 16 November of 2002. OP2.4.

Cerqueira, F, Cordeiro-da-Silva, A., Araújo, N., Gaspar, C., Simões, F. And Nascimento, MSJ Coleon U apotent inhibitor of T and B lymphocyte proliferation. XXVIII Reunião Annual da Sociedade Portuguesa deImunologia. Transplantação, tolerância e inflamação. Coimbra, 14 to 16 November of 2002.

Borges, M., Guilvard, E., Cordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. And Ouaissi, A. EndogenousTrypanosoma cruzi Tc52 protein expression induces the up regulation of the growth of murine macrophagesand fibroblasts and cytokine gene expression. Instituto de Biologia Molecular e Celular da Universidade doPorto. Porto, 29 January of 2002.

Cordeiro-da-Silva, A. Infecções Parasitárias Indutoras de Autoimunidade. Segundas Jornadas da SociedadePortuguesa de Ciências Farmacêuticas. Centro Cultural de Belém, Lisboa, Portugal, 16 Mars of 2001.

Ferraz, C., Cavaleyra, M., Cordeiro-da-Silva, A. and Lemesre, J. Expression of excreted-secreted antigens

during in vitro Leishmania infantum life cycle. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting.“Infection and Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade deLisboa, 22 to 24 November of 2001. Pag. 40.

Santos, M.L., Kong, P., Tomás, A. and Cordeiro-da-Silva, A. The role of polyamine derivates in host cellsand Leishmania infantum parasites. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting. “Infectionand Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária. Universidade de Lisboa, 22to 24 November of 2001. Pag. 25.

Borges, M., Guilvard, E., Cordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. Up regulation ofmurine macrophages and fibroblasts growth and cytokine gene expression by endogenous Trypanosomacruzi Tc52 protein expression. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting. “Infection andImmunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade de Lisboa, 22 to24 November of 2001. Pag.34.

Cerqueira, F., Cordeiro-da-Silva, A., Cidade, H., Kijjoa, A. and Nascimento, M.S.J. Artelastin: A potentinhibitor of T and B lymphocyte proliferation. Sociedade Portuguesa de Imunologia. XXVII Annual Meeting.“Infection and Immunity: Perspectives for vaccination”. Faculdade de Medicina Veterinária, Universidade deLisboa, 22 to 24 November of 2001. Pag. 39.

Cordeiro-da-Silva, A., Coutinho Borges, M.Guilvard, E. and Ouaissi, A Leishmania major ribosomal proteinS3a induces a polyclonal B cell activation and autoantibody production. XXVI Reunião Annual da SociedadePortuguesa de Imunologia. Jornadas de Actualização em Imunologia. Casa do Médico, Porto, Portugal.2000. C17.

Coutinho Borges, M., Zemzoumi, K., Ouaissi, A. and Cordeiro-da-Silva, A. Immunosupressive effect of 30kDa Leishmania major ribosomal protein at lymphocyte cell populations. XXV Reunião Annual da SociedadePortuguesa de Imunologia. Jornadas de Actualização em Imunologia. Casa do Médico, Porto, Portugal.1999.

Cordeiro-da-Silva, A. O sistema imune como agente terapêutico. Novas Terapias e TecnologiasFarmacêuticas. VI Fórum Farmacêutico. Porto, Portugal, 3 to 4 November of 1999.

Cordeiro-da-Silva, A. 1º Ciclo de conferências da Sociedade Portuguesa de Ciências Farmacêuticas. Papeldas Populações Linfocitárias na Leishmaniose. Faculdade de Farmácia, Universidade de Lisboa, Lisboa,Portugal. 1999.

Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. Determination of theimmunosupressive domain of Tc52 protein of Trypanosoma cruzi. V Reunião da Sociedade Portuguesa deParasitologia, Vila Real, Portugal e XXIV Reunião Annual da Sociedade Portuguesa de Imunologia. Jornadasde Actualização em Imunologia. Casa do Médico, Porto, Portugal, 12 to 14 November of 1998.

Cordeiro-da-Silva, A. Estudo de marcadores Imunológicos na Patologia de Chagas. Instituto de BiologiaMolecular e Celular, Porto. 1998.

Cordeiro-da-Silva, A., Guevara-Espinoza, A., Taibi, A. Ouaissi, A., and Minoprio, P. A 24 Kda Trypanosomacruzi specific antigen as a B cell activater. XXII Reunião Annual da Sociedade Portuguesa de Imunologia.Jornadas de Actualização em Imunologia. Imunoregulação e Terapêuticas Imunes. Curia, Portugal. 6 to 9November of 1996. C23.

Cordeiro-da-Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. The role of diguanosinetetraphosphate (Gp4G) in B cell response. XXII Reunião Annual da Sociedade Portuguesa de Imunologia.Jornadas de Actualização em Imunologia. Imunoregulação e Terapêuticas Imunes. Curia, Portugal. 6 to 9November of 1996. C22.

Cordeiro-da-Silva, A., E. C., Vicentelli, M. H. and Minoprio, P. - Papel das populações celulares CD8+ naresistência à infecção experimental pelo Trypanosoma cruzi. XXI Reunião Annual da Sociedade Portuguesade Imunologia. Avanços em imunologia clínica. Lisboa, Portugal. 9 to 11 November of 1995.

Cordeiro-da-Silva, A., Santos Lima, E. C., Vicentelli, M. H. and Minoprio, P. - Vb6 bearing T cells areinvolved in the mechanisms of resistance to Trypanosoma cruzi infection in the Xid experimental model ofChagas disease. XX Reunião Annual da Sociedade Portuguesa de Imunologia. Lisboa, Portugal. 10 to 12Novembro of 1994. C1.

Parra, J., Cordeiro-da-Silva, A., Cumano, A., Minoprio, P., Kourilsky, P., and Coutinho, A. - T cell repertoireactivated during acute phase of experimental T. cruzi infection XX Reunião Annual da Sociedade Portuguesade Imunologia. Lisboa, Portugal. 10 to 12 November of 1994. C2.

Cordeiro-da-Silva, A., Liegeard P., Arala Chaves, M. and Minoprio, P. - Identification of immunossupressive/mitogenic factors produced by of Trypanosoma cruzi. XIX Reunião Annual da Sociedade Portuguesa deImunologia. X Jornadas de Actualização em Imunologia. Da Fisiologia à terapêutica. Lisboa, Portugal. 25 to27 November of 1993. C17.

Cordeiro-da-Silva, A., Liegeard P., Tavares, D., Arala Chaves, M. and Minoprio, P. - Effect of P43immunossupressive/ B mitogenic factor of in the immunomodulation of Trypanosoma cruzi infection. XIXReunião Annual da Sociedade Portuguesa de Imunologia. 9ª Jornadas de Actualização em Imunologia. DaFisiologia do Sistema Imune às Terapêuticas Imunológicas. Lisboa, Portugal. 25 October. 1993. C20

Cordeiro-da-Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular modelto study antigens which induce resistance to murine Chagas´ Disease. XIX Reunião Annual da SociedadePortuguesa de Imunologia.10ª Jornadas de Actualização em Imunologia. Da Fisiologia do Sistema Imune àsTerapêuticas Imunológicas. Lisboa, Portugal, 25 October of 1993. C22

Cordeiro-da-Silva, A., Chaves-Arala, M. and Minoprio, P. Efeito de uma substância imunossupressora emitogénica B na imunomodelação da resposta à infecção por Trypanosoma cruzi. XVIII Reunião Annual daSociedade Portuguesa de Imunologia. 9º Jornadas de Actualização em Imunologia. Imunobiologia dainfecção por retrovirus. Porto, Portugal, 19 to 21 November of 1992. C10.

Cordeiro-da-Silva, A., Le Presle, T., Capron A. and Pierce R. - Cloning and characterization of a Cu/Znsuperoxide dismutase from Schistosoma mansoni. XVIII Reunião Annual da Sociedade Portuguesa deImunologia. 9º Jornadas de Actualização em Imunologia. Imunobiologia da infecção por retrovirus. Porto,Portugal, 19 to 21 November of 1992. C12.

Cordeiro-da-Silva, A. Silva, B.M., Gonçalves, J.R., Rodrigues, J.V., Casanovas, J.M. and Alfarroda, E.Correlação do perfil imunológico com o sucesso terapêutico. Reunião da Sociedade Portuguesa de PatologiaRespiratória. Viana do castelo, Portugal. 28 April of 1990.

Comunicações em painel ("poster")Comunicações em forma de painel em Encontros internacionais

Moreira, D., Santarem, N, Loureiro, I, Tavares J, Silva AM, Amorim, AM, Ouaissi, A, Cordeiro-da-Silva, A.Impacto f continuous axenic cultivation in Leishmania infantum virulence. EMBO/EMBL Symposium. NewPerspectives on Immunity to Infection. Heidelberg, Germany.19-22 May 2012.

M. Ouaïssi, F. Silvy, S. Costa lima, B. Sastre, I. Sielezneff, A. Cordeiro da Silva, D. lombardo, E. Mas, A.Ouaïssi. HDAC gene expression in pancreatic tumor cell lines submitted to the probinostat or trichostatinHDAC inhibitors. ESSR 2012 47th Annual Congress. Lille from 6 to 9 June 2012.

Ouaissi M, Silvy F, Costa Lima S, Sastre B, Sielezneff I, Cordeiro Da Silva A, Lombardo D, Mas E, Ouaissi A.Etude de l'efficacité Panobinostat LBH 589 sur l’inhibition de la croissance des lignées cellulairescancéreuses pancréatiques et la corrélation au niveau d’expression des HDAC. JFHOD 2012

Ouaissi M, Silvy F, Costa Lima S, Giger U, Zemmour K , Sastre B, IS, Cordeiro-da-Silva A, Lombardo D,Mas E, Ouaissi A. Characterization of the anti-pancreatic tumor cell effect induced by LBH589 and itsrelation to HDAC encoding genes expression. XX Porto Cancer Meeting: Drug Resistance in cancer frombiology to molecular targets and drug. April 28-29, Porto, Portugal. 2011

Ouaissi M, Cabral S, Tavares J, Sielezneff L, Dahan S, Cordeiro-da-Silva A, Lombardo D, Mas E, Bernard Aand Ouaissi A. Histone deacetylase (HDAC) encoding gene expres-sion in pancreatic cancer cell lines andcell sensitivity to HDAC inhibitors. ASCO: American Society of Clinical Oncology. Mars 29, USA. 2011

L. Moreira-Teixeira, M. Resende, O. Devergenw, J. Herbeuva, O. Hermine, E. Schneider, M. Dy, A.Cordeiro-da-Silva, and M- Leite-de-Moraes. "Foxp3 expressing human invariant NKT cells". 13e ColloqueCytoquines du Croisic de la Société Française d'Immunologie. May 10-12, 2010. Croisic, France.

A. Cordeiro-da-Silva, A.M. Silva, J. Tavares, M. Resende and G.H. Coombs. “TDR1 elicits a protectiveimmune response in the context of Leishmania infection”. 14th International Congress of Immunology, 22-27 August 2010, Kobe, Japan.

AM Silva, L McCaig, S Müller, A Cordeiro-Da-Silva and GH Coombs. “Characterization of Leishmaniadonovani Thiol Dependent Reductase 1 knockout”. BSP Spring and Malaria Meeting , March 29 - April 1 ,2010, Cardiff, UK

Anabela Cordeiro-da-Silva, Ana Marta Silva, Joana Tavares, Mariana Resende, Grahm Coombs. TDR1 elicitsa protective immune response in the contexto f infection for experimental leishmaniasis. InternationalImmunology, 2010, ISSN 0953-8178. PP-002-22.

M. Ouaïss, J. Tavares, A. Cordeiro da Silva, Kong Thoo Lin and Ali Ouaissi. Bisnaphthalimidopropylderivatives as new drug inhibitors of pancreatic cancer cells growth. Portuguese-British meeting onModulation of programmed cell deth and therapeutic targets in cancer and neurodegenerative diseases,IPATIMUP, 2009. Porto.

Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela Cordeiro-da-Silva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. 2ndEuropean Congress of Immunology, September 13-16, 2009, Berlim, Germany.

Bruno Neves, Ricardo Silvestre, Joana Cunha, Joana Tavares, Mariana Resende, Ali Ouaissi, Maria CelesteLopes, Maria Teresa Cruz and Anabela Cordeiro-da-Silva. Immunomodulation of dendritic cells by virulentand attenuated Leishmana infantum strains. 2nd European Congress of Immunology, September 13-16,2009, Berlim, Germany.

Mariana Resende, Ricardo Silvestre, Nuno Santarém, Sandra Gomes Pereira and Anabela Cordeiro-da-Silva. Leishmania infantum excreted / secreted molecules modify dendritc cells activation status. 2ndEuropean Congress of Immunology, September 13-16, 2009, Berlim, Germany.

Ricardo Silvestre, Nuno Santarém, Joana Cunha, Luís Cardoso, Javier Nieto, Eugenia Carrillo, Javier Morenoand Anabela Cordeiro da Silva. Serological evaluation of experimental infected dogs by LICTXNPX-ELISAand Amastigote-Flow cytometry. 4th World Congress on Leishmaniasis 2009. 3rd to 7th February2009, Lucknow, India

Ricardo Silvestre, Ana M. Silva, Anabela Cordeiro-da-Silva1 and Ali Ouaissi. The contribution of toll likereceptor 2 to the innate recognition of a Leishmania infantum sir2 protein. 4th World Congress onLeishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India

Ricardo Silvestre, Nuno Santarém, Lúcia Teixeira, Joana Cunha, Henk Shallig and Anabela Cordeiro daSilva. Evaluation of Leishmania species reactivity in human serological diagnostic of leishnaniasis. 4th WorldCongress on Leishmaniasis 2009. 3rd to 7th February 2009, Lucknow, India

Medhi Ouaissi,Joana Tavares, Anabela Cordeiro da Silva, Paul Kong Thoo Lin and Ali Ouaissi.Bisnaphalimidopropyl derivatives as new drug inhibitors of pancreatic câncer cells growth. Portuguese-British Meeting on Modulation of programme cell death and therapeutic targets in cancer andneurodegenerative disease. 2009, 23 January, IPATIMUP, Porto.

Tavares, J., Ouaissi, A., Santarém, N., Thoo Lin, PK., Cordeiro-Da-Silva , A.Enzymatic characterization ofthe Leishmania infantum cytosolic SIR2 related protein 1 (LiSIR2RP1) and search for target specificinhibitors. Woods Hole 21-25th of September, USA

Santarém,N., Silvestre, R., Tavares, J., Silva, M., Cabral, S., Maciel, J., Cordeiro-da-Silva, A.Immunological role of Leishmania secreted and nonsecreted antigens. BSP Spring, Trypanosomiasis /Leishmaniasis and Malária meeting, March 30th-April 2nd2008. NewCastle, UK.

Silvestre R, Santarém N, Cardoso L, Nieto J, Moreno J, Cordeiro-da-Silva A. The potential of flow cytometryas a diagnostic technique for canine leishmaniasis. X Congreso Ibérico de Parasitología, July 15-20, 2007,Madrid, Spain.

Joana Tavares, Ali Ouaissi, Marta Silva, Paul Kong Thoo Lin, Denis Sereno and Anabela Cordeiro-da-Silva.The in vitro and in vivo effect of Bisnaphthalimidopropyl polyamine derivatives against experimentalLeishmania infantum infection. 4th COST B22 Congress on Drug Discovery and Development for ParasiticDiseases. 10th to 13th of June, 2007 Dundee, Scotland, United Kingdom.

Joana Tavares, Ali Ouaissi, Nuno Santarém and Anabela Cordeiro-da-Silva. Enzymatic characterization ofthe Leishmania infantum Silent Information Regulator 2 and its role in the parasite life cycle stages. Drugdevelopment for parasitic disease: COST B22 Annual Congress in Dundee, UK, 10-13 June 2007

Silvestre R., Cordeiro-da-Silva A., Ouaissi A., Leishmania cytosolic SIR2 deacetylase induces murine B-cellactivation in vitro and in vivo and antibody specific immune response. ESF-EMBO Symposium on B cellscross the divide from in silico to the whole person, May 13-18, 2006, Sant Feliu de Guixols, Spain

Sandra Carvalho; Nuno Santarém; Rosa Barreira da Silva; Susana Romão; Anabela C. Silva; Vítor Costa,Ana M Tomás. – Iron acquisition in Leishmania amastigotes. Gordon Research Conference: Biology of Host-Parasite Interactions. 25th - 30th June, Newport, Rhode Island, USA. 2006.

Santarém N., Silvestre R., Tavares J., Cabral S., Silva M., Castro H., Tomás A. and Cordeiro-da-Silva A.Comparative study of the immunological profile induced by three Leishmania infantum proteins involved inthe trypanothione cascade. 11th International Congress of Parasitology, ICOPA XI, August 6-11, 2006,Glasgow, Scotland.

N. Santarém; S. Carvalho; S. Romão; A. Cordeiro-da-Silva; V. Costa and A. Tomás.- Iron acquisition inLeishmania amastigotes. 11th International Congress of Parasitology. 6th - 11th August. Glasgow, Scotland.

Santarém N., Silvestre R., Nieto J., Moreno J. and Cordeiro-da-Silva A. An excreted/secreted protein fromL. infantum as a diagnostic marker in experitmental canine infection. 16th European Congress ofImmunology, September 6-9, 2006, Paris, France.

Sandra Carvalho, Nuno Santarém, Rosa Barreira da Silva, Susana Romão, Anabela Silva, Vítor Costa, AnaTomás. - Iron acquisition in Leishmania infantum amastigotes. Transporters 2006. Parma, Italy. 6th - 9thSeptember, 2006.

Santarém N., Silvestre R., Nieto J., Moreno J. and Cordeiro-da-Silva A. The use of leishmania recombinantproteins as diagnostic markers in experimental canine infection. XXXII Reunião Anual da SociedadePortuguesa de Imunologia, October 13-14, 2006, Braga, Portugal.

Marta Silva, Joana Tavares, Joana Maciel, Graham H. Coombs, Anabela Cordeiro-da-Silva “Leishmaniamajor TDR1 protein induces a specific IgG1 antibody production”. 16th European Congress of Immunology.September 6-9, 2006, Paris, France.

Marta Silva, Joana Tavares, Joana Maciel, Ana Tomás, Anabela Cordeiro-da-Silva “Characterization of anew 50KDa Leishmania infantum protein”. 11th International Congress of Parasitology. August 6-11, 2006,Glasgow, United Kingdom.

Joana Tavares, Mehdi Ouaissi, Ali Ouaissi and Anabela Cordeiro da Silva. “The role of cisplatin as anantileishmanial drug” 11th International Congress of Parasitology. August 6-11, 2006, Glasgow, UnitedKingdom.

Olga Borges, Anabela C. da Silva, Joana Tavares, Adriano de Sousa, Hans E. Junginger. “Immune responseto hepatitis B surface antigen encapsulated into coated chitosan nanoparticles following oral administration”,CRS (32nd Annual meeting & Exposition of the Controlled Release Society), July 2006, Vienna, Austrian

Maciel, J., Silva, M., Tomás, A. and Cordeiro-da-Silva, A. “A new excreted/secreted protein fromLeishmania infantum induces a humoral immune response”. 5th International Congress PharmaceuticalSciences CIFARP 2005. Brasil September 25 – 28, 2005.

Tavares, J., Lin, P.K.T. and Cordeiro-da-Silva, A. New polyamine derivative compounds active againstLeishmania infantum induce apoptosis-like-death. 2nd Congress of the Portuguese Society ofPharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled ReleaseSociety. Coimbra. 31st-2nd April. 2005. P-7.

Tavares, J., Ouaissi, A., Ouaissi, M. and Cordeiro-da-Silva, A. Antileishmanial activity using a classicalanticancer compound. 9º Congresso da Sociedade Ibérica de Citometria de Fluxo. Porto. 19-21 de Maio de2005. PO068-MIC. 2005.

Tavares, J., Ouaissi, A., Thoo Lin, P.K. and Cordeiro da Silva, A.. New Polyamine Derivative CompoundsActive Against Leishmania infantum Expressing Stable Luciferase Activity Induce Apoptosis-like Death. 2ndCOST B22 Congress on Drug Discovery and Development for Parasitic Diseases. Siena. 29 September- 1October 2005. P- 49. 2005.

Santarém, N; Cardoso, L.; Tomás, A.; Cordeiro-da-Silva,A. Flow Cytometry analysis as an alternativediagnostic method to canine Leishmaniasis. 9º Congresso da Sociedade Ibérica de Citometria. Porto. 19 a21 de Maio de 2005.

R. Silvestre, A. Cordeiro-da-Silva, A. and A. Ouaissi – “A recombinant Leishmania antigen related to theSilent Information Regulatory 2 (SIR2) protein family induces a B cell activation and antibody specificimmune response”. The Eighth Annual Conference on Vaccine Research., Baltimore, EUA, 9-11 Maio 2005,P47

Maciel, J., Silva, R., Tomás, A. and Cordeiro-da-Silva, A. A new excreted/secreted protein from Leishmaniainfantum induces a humoral immune response” 5th International Congresso f Pharmaceutical Sciences.Ribeirão Preto, Brasil, de 25 a 28 de Setembro de 2005.

Ferreira, H., L.F.C. Lima, J., Cordeiro-da-Silva, A., Tavares, J. and Reis, S. Antioxidant profile of NSAIDS insplenocyte and membrane models by fluorescence measurements. MAF9 9th International Conference onMethods and Applications of Fluorescence. Lisbon, Portugal, de 4 a 7 Setembro de 2005

O. Borges, G. Borchard, J.C. Verhoef, A. de Sousa, A. C. da Silva, H.E. Junginger. “The entrappment of thehepatitis B antigen within a new nanoparticulate delivery system for mucosal vaccination”, Congress“Immunopotentiators in Modern Vaccines” - IMV 2005, Torrequebrada Hotel, Malaga, Spain, Mai 2005.

Tavares, J., Silva, M., Tomás, A. Cordeiro-da-Silva, A. A new excreted/secreted protein from Leishmaniainfantum induces a humoral immune response. 5th International Congress f Pharmaceutical Sciences.Ribeirão Preto, Brasil, de 25 a 28 Setembro de 2005.

Cordeiro-da-Silva, A., Tavares, J., Santarém, N., Silvestre, R. and Ouaissi A. Antibodies Against rLmS3aEnhance the Leishmania Uptake by Murine Peritoneal Macrophages. 12th International Congress ofImmunology and 4th Annual Conference of FOCIS, Montréal, Canada, de 18 a 23 Julho de 2004.

Tavares, J., Ouaissi, A., Lin, P.K.T., Tomás, A. and Cordeiro-da-Silva, A. Apoptosis–Like Death ofLeishmania infantum Induced by Polyamine Derivative Compounds. 12th International Congress ofImmunology and 4th Annual Conference of FOCIS, Montréal, Canada, de 18 a 23 Julho de 2004.

Tavares, J., Borges, M., Cordeiro-da Silva, A, Kong Thoo Lin, P.. The role of polyamine derivative drugs inthe inhibition of parasite proliferation by an apoptotic mechanism. Gordon Conference, Connecticut College,New London, CT, USA, 15 to 20 June of 2003.

Castro, H., Sousa, C., Novais, M., Santarém, N., Cordeiro-da-Silva, A. and Tomás, A. Two distincthydroperoxide detoxification systems coexist in Leishmania infantum. 6º Portuguese Congress on FreeRadical in Chemistry, Biology and Medicine. 1º Luso-Spanish Congress on Free Radicals. Coimbra, Portugal.4 to 6 Dezember of 2003. Poster 019.

Lima, S.A.C., Cordeiro-da-Silva, A., Gameiro, P., Reis, S., Lima, J.L.F.C. and Castro, B. Reconstitution ofATPase activity in proteolipossomes of mouse mdr3 p-glycoprotein. 17 ECIS - European Colloid andInterface Society Conference Firenze. 21 to 26 September of 2003. P7/35, pag. 495.

Borges, M., Cordeiro-da-Silva, A, Sereno, D., Ouaissi, A T. cruzi Tc52 derived synthetic peptide mediated

suppression of IL-2 and IFN-gamma production. Woods Hole ImmunoParasitology Meeting 2002. WoodsHole, Massachusetts, USA. 28 to 30 Apbril of 2002. #15.

Garzon, E, Borges, M., Cordeiro-da-Silva, A., Guilvard, E., Mosseno, MF, Guevara, A, Breniere, SF andOuaissi, A . Trypanosoma cruzi carrying a target deletion of a Tc52 proteion-encoding allele elicitsattenuated Chagas’ disease in mice. Molecular Epidemiology and Evolutionary Genetics of InfectiousDisease Society. Montpellier, France. 23 to 26 July of 2002.

Cordeiro-da-Silva, A., Ferraz, C., Cardoso, L., Rodrigues, M., Castro, H., Tomás, A, Cabral, M. And Ouaissi,A Antibodies produced during Leishmania infantum natural infection recognise natural and exogenousantigens. British Society for Parasitology Trypanosomiasis and Leishmaniasis Seminar. Edinburgh. 8 to 11September of 2002. IM03.

Araujo, N., Borges, M., Ouaissi, A and Cordeiro-da-Silva, A The role of rLmS3arp in the parasitemia controlduring acute phase of experimental Leishmania infantum infection. British Society for ParasitologyTrypanosomiasis and Leishmaniasis Seminar. Edinburgh. 8 to 11 September of 2002. IM04.

Borges, M., Guilvard, E., Cordeiro-da-Silva, A., Vergnes, B., Zemzoumi, K. and Ouaissi, A. EndogenousTrypanosoma cruzi Tc52 protein expression up regulates the growth of murine macrophages and fibroblastsand cytokine gene expression. Clube da Sociedade Francesa de Vacionologia. Institut Pasteur de Paris,França, 16 to 17 October of 2001. Résumé 26.

Santos, M.L.N.C., Ferraz, C.A.S., Kong, P., Tomás, A. and Cordeiro-da-Silva, A. Immunological effects ofpolyamine drugs in host and parasite cells. A EURO CONFERENCE. 2nd International Meeting on CellularResponses to oxidative and Osmotic Stress. Sensing, signalling and gene expression, Póvoa de Varzim,Portugal, 7 to 10 November of 2001. Pag.148.

Castro, H., Lopes, R. B., Cordeiro-da-Silva, A. and Tomás, A A mithocondrial H2O2 detoxification pathwayin Leishmania infantum. 27th Meeting of the Federation of European Biochemical Societies. Lisboa, Portugal,30 June to 5 July of 2001. PW9-041.

Castro, H., Lopes, R.B., Cordeiro-da-Silva, A. and Tomás, AM. The mitochondrial H2O2 detoxificationsystem of Leishmania infantum. 4th COST-B9 Congress on Antiprotozoal Chemotherapy, Lisboa, Portugal, 6to 9 May of 2001. P06.

Coutinho Borges, M., Guilvard, E., Ouaissi, A., Cordeiro-da-Silva, A. Immunossuppressive effect of 30kDaLeishmania major ribosomal protein at linfocyte cell populations. 37. Congrès Annuel de la SociétéFrançaise de Parasitologie, Montpellier, France, 1 to 3 Mars of 2000. Pag. 72.

Borges, M., Guilvard, E., Cordeiro-da-Silva, A and Ouaissi, A. Endogenous Trypanosoma cruzi Tc52 proteinexpression up regulates the growth of murine macrophages and fibroblasts and cytokine gene expression.Comité de avaliação INSERM: Montpellier, France, 14 September of 2000.

Castro, H., Cordeiro-da-Silva, A. and Tomás, A. A mitochondrial peroxiredoxin from Leishmania infantum:analysis of its role in parasite protection to oxidants. Molecular Parasitology XI. Woods Hole, USA, 17 to 21September of 2000. Pag. 265A.

Cordeiro da Silva, A., Coutinho Borges, M., Guilvard, E. and Ouaissi, A. Leishmania major RibosomalProtein Induce a Polyclonal B Cell Populations.14th European immunology Meeting, Poznan, Polonia, 23 to27 September of 2000. W-23, 448.

Coutinho Borges, M., Guilvard, E., Ouaissi, A., Cordeiro-da-Silva, A. Immunossuppressive effect of 30kDaLeishmania major ribosomal protein at linfocyte cell populations. 37. Congrès Annuel de la SociétéFrançaise d’ Immunologie, Lille, France, 24 to 26 November of 1999. 37, pag. 72.

Parra, J., Cordeiro da Silva, A., Cumano, A., Minoprio, P., Kourilsky P. and Coutinho, A. - T cell repertoireactivated during acute phase of experimental T. cruzi infection. XXI Annual Meeting on Basic Research inChagas´ Disease. Caxambu, Brasil, 9 to 11 November of 1994. IM-015.

Cordeiro da Silva, A., Santos Lima, E. C., Vicentelli, M. H. and Minoprio, P. - The resistance of Balb.XIDmice to Trypanosoma cruzi infection is associated to presence of Vb6 bearing T cells. XX Annual Meeting onBasic Research in Chagas´Disease. Caxambu, Brasil, 9 to 11 November of 1993. IM-023

Cordeiro da Silva, A., Liegeard P., Arala Chaves, M. and Minoprio, P. - Identification of immunossupressive/ mitogenic factors of Trypanosoma cruzi. XX Annual Meeting on Basic Research in Chagas´Disease.Caxambu, Brasil, 9 to 11 November of 1993. IM-7.

Cordeiro da Silva, A., Liegeard P., Tavares, D., Arala Chaves, M. and Minoprio, P. - Effect of P43immunossupressive/ B mitogenic factor of Candida albicans in the immunomodulation of Trypanosoma cruziinfection. XX Annual Meeting on Basic Research in Chagas´Disease. Caxambu, Brasil, 9 to 11 November of1993. IM-8

Cordeiro da Silva, A., Liegeard P. and Minoprio, P. - XID: mutation: immunobiological and molecular modelto study antigens which induce resistance to murine Chagas´ Disease. XX Annual Meeting on BasicResearch in Chagas´ Disease. Caxambu, Brasil, 9 to 11 November of 1993. IM-6.

Cordeiro da Silva, A., Le Presle, T., Capron, A., and Pierce R. - Cloning and characterization of a Cu/Znsuperoxide dismutase from Schistosoma mansoni. Molecular and Cellular Biology of Host-parasite

interactions - Keyston Symposium. Park City, Utath, USA. 13 to 26 January of 1992.

Comunicações em painel em Encontros Nacionais

Barros D, Costa-Lima S, Cordeiro-da-Silva A. Immunotherapeutic of mannosylated nanoparticles. XXXVIIIAnnual Meeting of the Portuguese Society of Immunology. 25-27 November 2012.

Ramos-Silva C, Silvestre R, Santarém N and Cordeiro-da-Silva. Impact of axenic culture conditions inLeishmania infantum virulence. IJUP: Investigação Jovem na U.Porto. 17-19 February, Porto, 2011.

Costa Lima S, Roussaki M, Sampaio S, Detsi A, Kefalas P and Cordeiro-da-Silva A.. Leishmania infantumactivity of heterocyclic scaffolds determined by flow cytometry Se-cond I3S Scientific RetreatIBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Costa Lima S, Rodrigues V, Garrido J, Borges F, Thoo Lin PK and Cordeiro-da-Silva A.. Pegylatednanoparticles for encapsulation of bisnaphthalimidopropyl derivatives against Leishmania infantum. SecondI3S Scientific Retreat IBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Ramos-Silva C, Santarém N, Cordeiro-da-Silva A and Silvestre R. Modulatory activity of several definedculture mediums on Leishmania infantum virulence. Second I3S Scien-tific Retreat IBMC/INEB/IPATIMUPtogether in science. 6-7 May, Esposende, 2011.

Ribeiro D, Rodrigues V, Cordeiro-da-Silva A and Silvestre R. Manipulation of host cell cycle by Leishmania

parasites: a potential evasion mechanism. Second I3S Scientific Re-treat IBMC/INEB/IPATIMUP together inscience. 6-7 May, Esposende, 2011.

Moreira D, Santarém N, Loureiro I, Tavares J, Silva AM, Ouaissi A, Silvestre R and Cordeiro-da-Silva A.Impact of axenic culture in Leishmania infantum virulence. Second I3S Scientific RetreatIBMC/INEB/IPATIMUP together in science. 6-7 May, Espo-sende, 2011.

Loureiro I, Tavares J, Cordeiro-da-Silva A. Ribose 5-phosphate isomerase B, a common and potentialtarget against parasitic infections by members of the Trypanosomatidae family. Second I3S ScientificRetreat IBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Resende R, Neves B, Cunha J, Cunha D, Cruz T, Cordeiro-da-Silva A and Silvestre R. Differential effect ofLeishmania infantum on infected and bystander dendritic cells. Se-cond I3S Scientific RetreatIBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Resende M, Cunha J, Costa Lima S, Moreira D, Cordeiro-da-Silva A and Silvestre R. Early stages of visceralLeishmania infection. Second I3S Scientific Retreat IBMC/INEB/IPATIMUP together in science. 6-7 May,Esposende, 2011.

Sousa S, Lopes AP, Cardoso L, Silvestre R, Schallig H, Cordeiro-da-Silva A. Seroepidemiological survey ofLeishmania infantum infection in dogs from northeastern Portugal. Second I3S Scientific RetreatIBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Moreira-Teixeira L, Resende M, Coffre M, Devergne O, Herbeuval JP, Hermine O, Schneider E, Rogge L,Ruemmele FM, DY M, Cordeiro-da-Silva A & Leite-de-Moraes MC. Pro-inflammatory environment dictatesthe IL-17-producing capacity of human invar-iant NKT cells. Second I3S Scientific RetreatIBMC/INEB/IPATIMUP together in science. 6-7 May, Esposende, 2011.

Cunha J, Moreno J, Cordeiro-da-Silva A. In vitro comparative study between naturally attenuated andvirulent strains of Leishmania infantum. Second I3S Scientific Retreat IBMC/INEB/IPATIMUP together inscience. 6-7 May, Esposende, 2011.

Sampaio S, Costa Lima S, Detsi A and Cordeiro-da-Silva. Bioactivity of flavonoids against Leishmaniainfantum determined by flow cytometry. IJUP: Investigação Jovem na U.Porto. 17-19 February, Porto, 2010.

Lúcia MOREIRA-TEIXEIRA, Mariana RESENDE, Odile DEVERGNE, Jean-Philippe HERBEUVAL, OlivierHERMINE, Elke SCHNEIDER, Michel DY, Anabela CORDEIRO-DA-SILVA, and Maria C. LEITE-DE-MORAES.Foxp3-expressing human invariant NKT cells. I3S Scientific Retreat 2010, 6-7 May, Povoa de Varzim –Portugal.

AM Silva, GH Coombs, A Cordeiro-Da-Silva. “The Leishmania TDR1 as a DNA vaccine does not protect miceagainst visceral leishmaniasis”. SPI. October 26-28, 2008 Porto, Portugal

Cunha J, Moreno J Cordeiro-da-Silva A. Comparative study between naturally attenuated and virulentstrains of Leishmania infantum: culture conditions and infectiveness". XIV Congresso Português deParasitologia 2010, Porto, Portugal, Poster P-31

Resende M, Silvestre R, Neves B, Cunha J, Cruz MT & Cordeiro-da-Silva A. "Differential effect ofLeishmania infantum on infected and bystander dendritic cells". XXXVI Annual Meeting of the PortugueseSociety for Immunology, September 20-11, 2010, Braga, Portugal

Diana Moreira, Ricardo Silvestre, Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela Cordeiro-da-Silva;Impact of axenic culture in Leishmania infantum virulence no XIV Congresso Português de Parasitologia,Porto 8-10 de Setembro de 2010-

Diana Moreira, Ricardo Silvestre, Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela Cordeiro-da-Silva.Different sensitivity of the Leishmania strains in the complement resistance with time culture and parasiteform” presented I3S Scientific Retreat, 6 e 7 de Maio de 2010, no Hotel Axis Vermar, Póvoa de Varzim.

Sofia Lima and Anabela Cordeiro da Silva. 3º Encontro de Jovens Investigadores da Universidade do Porto,Portugal, Fevereiro. “Bioactivity of flavonoids against Leishmania infantum determined by fow cytometry”.2010.

Inês Loureiro, Joana Tavares, Ali Ouaissi and Anabela Cordeiro da Silva. Different sensitivities ofLeishmania strains to the complement mediated lysis. XXXV Annual Meeting of the Portuguese Society forImmunology, Septemer, 28-30, 2009, Lisboa, Portugal.

Sandra Gomes Pereira and Anabela Cordeiro da Silva. Nramp-functionality affects dendritic cell functionduring in vitro Leishmania infection. XXXV Annual Meeting of the Portuguese Society for Immunology,Septemer, 28-30, 2009, Lisboa, Portugal.

Bruno Neves, Ricardo Silvestre, Mariana Resende, Joana Cunha, Inês Loureiro, Joana Tavares, Ali Ouaissi,Maria Celeste Lopes, Maria Teresa Cruz and Anabela Cordeiro Silva. PI3 kinase/AKT activation andNF.kappa B impairment: a strategy used by Leishmabia parasites to impair DC function. XXXV AnnualMeeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.

Lúcia Teixeira, Odile Devergne, Jean-Philippe Herbeuval, Olivier Hermine, Michel Dy, Anabela Cordeiro-da-Silva and Maria Leite-de-Moraes. Human invariant Natural Killer T cells: a new source of IL-17. XXXVAnnual Meeting of the Portuguese Society for Immunology, September, 28-30, 2009, Lisboa, Portugal.

Sofia Lima and Cordeiro-da-Silva, A. 8th Inorganic Chemistry Conference, Curia, Portugal, Setembro. “Invitro evaluation of bisnaphthylimidopropul derivatives – loaded PLGA nanoparticles of Leishmania infectedcells”.

Silva, AM., Coombs, GH and Cordeiro-da-Silva, A. The Leishmania TDR1 as a DNA vaccine does not protectmice against visceral leishmaniasis. XXXIV Annual Meeting of the Portuguese Society for Immunology,October, 26-28, 2008, Porto, Portugal.

Neves, B., Cruz, MT., Francisco, V., Duarte, C, Garcia-Rodriguez, C., Silvestre, R., Cordeiro-da-Silva, A andLopes, M.C. Differential roles of PI3 kinase, MAPKs and NF-KappaB on the maturation of skin dendritic cells.XXXIV Annual Meeting of the Portuguese Society for Immunology, October, 26-28, 2008, Porto, Portugal.

Sofia A.C. Lima, Joana Tavares, Paula Gameiro, Baltazar de Castro and Anabela Cordeiro-da-Silva.CITOMETRIA DE FLUXO – UM MÉTODO PARA QUANTIFICAR E IDENTIFICAR INIBIDORES DA P-GLICOPROTEÍNA ”. 2007. 6º Encontro Nacional de Química Analítico. Sociedade Portuguesa de Química.Instituto Superior Técnico.

Sofia Lima and Anabela Cordeiro-da-Silva. 45th Eurotox Congress, Rodes, Grecia. “Effect of P-Glycoproteininducers on its expression and activity in Caco-2 cells”. (in collaboration with Requimte - ToxicologyDepartment, Faculty of Pharmacy, University of Porto). 2008.

Sofia Lima and Anabela Cordeiro-da-Silva. Nanomedicine 2008, Barcelona, Espanha, Setembro.“Encapsulation of bisnaphthalimidopropyl derivatives, two novel anti-Leishmania drugs, in biodegradablePLA and PLGA nanoparticles”.

Teixeira, L., Santarem, N., Silvestre, R., Schalling, H.D., Cordeiro-da Silva, A. (2007). Evaluation of the flowcytometry potential for leishmaniasis diagnosis in humans. SPI. Lisboa.

Santarém N., Silvestre R., Tavares J., Cabral S., Silva M., and Cordeiro-da-Silva A. Comparative study ofthe cytokine production in vitro and in vivo of three proteins involved in the trypanothione cascade. IISimpósio Nacional de Citocinas, May 8th, 2006, Coimbra, Portugal.

Marta Silva, Joana Tavares, Joana Maciel, Graham H. Coombs, Anabela Cordeiro-da-Silva “TDR1 induce aTh2 profile antibody production”. Portuguese Society for Immunology XXXII Annual Meeting. October 13-14,2006, Braga, Portugal

Cabral S., Silvestre R., Santarém N., Silva M., Tavares J., Romão S., Tomás A., Cordeiro-da-Silva A.“Characterization of the immune response to an excreted/secreted Leishmania infantum tryparedoxin”.Portuguese Society for Immunology XXXII Annual Meeting, “Innate and acquired immunity: Evolution andregulation”. October 13-14, 2006, Braga, Portugal

Olga Borges, Joana Tavares, Gerrit Borchard, Adriano de Sousa, Hans E. Junginger and Anabela C. daSilva. “Nanotechnology approach and the use of CpG ODN for an oral hepatitis B vaccine”, XXXII annualMetting of SPI; 13-14th October 2006, University of Minho - Braga, Portugal.

Silvestre R., Cordeiro-da-Silva A., Vergnes B., Sereno D. and Ouaissi A. Attenuated SIR2-deficientLeishmania infantum as a vaccine candidate, XXXII Reunião Anual da Sociedade Portuguesa de Imunologia,October 13-14, 2006, Braga, Portugal.

Sena Esteves, F., Teixeira, N., Santos Silva, A., Cordeiro da silva, A., Castro, E., Elsa B., Marques, F.,Correia da Silva, G., Rebelo, I., Belo, L., Tavares, J. Cepa, M., Silvestre, R., Catarina, R., Santos, R.,Coimbra, S., Maciel, J., Silva, M., Santarém, N. “Research activities on inflammation, pregnancy and DNAreplication” integrado no simpósio “Os Farmacêuticos no Sistema de Saúde” Faculdade de Farmácia daUniversidade de Lisboa, nos dias 19 e 20 de Maio de 2005.

Lima, S.A.C., Cordeiro-da-Silva, A., Gameiro, P. and Castro, B. Evaluation of the struture and function ofthe reconstituted P-glycoprotein multidrug transporter. Requinte: rede de química e tecnologia. 3º encontro.Fátima. 9 to 10 January of 2004. Pag. 39.

Cordeiro-da-Silva, A., Santarém, N., Tavares, J., Ferreira, N., Manso, A., Ouaissi, A. and Tomás, A. Use ofLeishmania recombinant proteins for diagnosis and monitoring cure of human Leishmaniasis. 1º Workshopde Bioquímica Clínica. Porto. 15 Dezember of 2003. Pag. 44.

Santarém, N., Ouaissi, A., Tomás, A., Cardoso, L., Rodrigues, M. and Cordeiro-da-Silva, A., Use of arecombinant Leishmania protein antigens to monitor visceral leishmaniasis in dogs. XXIX Annual meeting.Chronic infections. Sociedade Portuguesa de Imunologia. Porto. 9 to 11 October of 2003. P32.

Lima, A.C., Cordeiro-da-Silva, A., Reis, S., Lima, J.L.F.C., Gameiro, P. And Castro, B. Purificação da P-glicoproteína (MDR3) funcional a partir de células de Pichia pastoris. 1º Congresso da SociedadePortuguesa de Ciências Farmacêuticas. Lisboa. 14 to 16 April of 2003. P-35.

Tavares, J., Santos, ML, Araújo, N., Kong Thoo Lin, P., Castro, H., Tomás, A., Cordeiro-da-Silva, A.Trypanothione: a target to polyamine derivates compounds in Leishmania infantum. Lisboa. XXX CongressoNacional de Bioquimica. 5 to 7 Dezember of 2002. P9.

Borges, M., Cordeiro-da-Silva, A., Sereno, D. and Ouaissi, A T. cruzi Tc52 derived synthetic peptidemediated suppression of IL-2 and IFN gamma production. Lisboa. XXX Congresso Nacional de Bioquímica. 5to 7 Dezember of 2002. P23.

Cerqueira, F, Cordeiro-da-Silva, A., Araújo, N., Gaspar, C., Simões, F. And Nascimento, MSJ 7a-Acetoxi-6b-Hydroxyleanona: A potent inhibitor of T and B lymphocyte proliferation. XXVIII Reunião Annual daSociedade Portuguesa de Imunologia. Transplantação, tolerância e inflamação. Coimbra. 14 to 16November of 2002. PP07.

Castro, H., Lopes, R. B., Cordeiro-da-Silva, A., Tomas, A. M. A mitochondrial peroxiredoxin fromLeishmania infantum: analysis of its role in parasite protection to oxidative stress. XII Congress Nacional deBioquímica. Povoa de Varzim. 28 to 30 September of 2000.

Cordeiro-da-Silva, A., Coutinho Borges, M., Guilvard, E. and Ouaissi, A. A. Polyclonal B cell populationsinduced by Leishmania major ribosomal protein. XII Congresso Nacional de Bioquímica, SociedadePortugesa de Bioquímica. Póvoa do Varzim. 28 to 30 September of 2000. P 8.5.

Borges, M., Zemzoumi, K., Ouaissi, A. and Cordeiro-da-Silva, A. Immunosupressive effect of 30 kDaLeishmania major ribosomal protein at lymphocyte cell populations. XXV Reunião Annual da SociedadePortuguesa de Imunologia. Jornadas de Actualização em Imunologia. Imunologia das infecções virais.Lisboa. 25 to 27 November of 1999. P9.

Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. ”Determination of the minimalfunctional immunosuppressive domain of Tc52 protein from Trypanosoma cruzi” V Reunião da SociedadePortuguesa de Parasitologia. Trás-os-Montes. 5 to 7 November of 1998. P14.

Zemzoumi, K., Borges, M., Guilvard, E., Cordeiro-da-Silva, A. and Ouaissi, A. ”Caracterização funcional dodomínio immunossupressor da proteína TC52 de Trypanosoma cruzi” V Reunião da Sociedade Portuguesade Parasitologia, Vila Real. 5 to 7 November of 1998. D7.

Cordeiro da Silva, A., Pena, M. R., Silero, A., Silero, M. and Teixeira, N. The effect of diguanosinetetraphosphate in B response. X Congresso Nacional de Bioquímica. Universidade do Minho. Braga. 31October to 2 e November of 1996. P8-11.

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Documents

Curriculum vitae - CNPEMpages.cnpem.br/nmtrypi/wp-content/uploads/sites/49/... · Overview Edit CV Anabela Cordeiro Silva End session Overview 1. Personal data Full Name Anabela Cordeiro