APRIL 2013 CURRICULUM VITAE

Honglei Chen

Education

1993 M.D. TianJin Medical University 1996 M.Sc. Chinese Academy of Preventive Medicine 2001 Ph.D. Tufts University

Academic Appointments

2001-03 Research Associate in Nutritional Epidemiology, Harvard School of Public Health, Boston, MA

2003-05 Instructor in Nutritional Epidemiology, Harvard School of Public Health, Boston, MA

2005-date Tenure-Track Investigator, National Institute of Environmental Health Sciences, Research Triangle Park, NC

2011-date Adjunct Associate Professor at University of North Carolina, Chapel Hill, NC

Other Professional Positions and Major Visiting Appointments

1992 Intern in Medicine, HuanHu Hospital, TianJin, China 1999-00 Visiting Fellow in Cancer Epidemiology, National Cancer Institute, MD

Relevant Teaching Experience

2001-03 Invited lectures on “Nutritional Epidemiology”, Tufts University 2002 Invited lecture on “Design of Epidemiologic Studies for Nutrition

Research”, Tufts University 2003-05 Invited lectures on “Nutritional Epidemiology”, Harvard School of Public

Health 2003 Tutor on “Clinical Epidemiology”, Harvard Medical School 2007-08 Invited lectures on “Environmental Epidemiology”, University of North

Carolina, Chapel Hill, NC

Awards and Honors

1988-93 Scholarship Award for Outstanding Students (TianJin Medical University) 1990 Wang K-CH Metropolitan Scholarship Award (Advanced Education

Committee of TianJin) 1996 Excellent Thesis Award (Chinese Academy of Preventive Medicine) 1996-00 Scholarship Award (Tufts University) 1999-00 Visiting Fellowship Award (National Cancer Institute) 2002-03 National Research Service Award (National Institutes of Health)

Professional Societies

Society for Epidemiologic Research American Academy of Neurology American College of Nutrition (past) Movement Disorders Society (past)

Extramural Grants

2002-04 Michael J. Fox Co-Investigator Prospective study of $ 557,837 Foundation non-steroidal anti-inflammatory

drugs and risk of Parkinson’s disease

2003-04 NIH RO1 Co-Investigator Prospective epidemiological $ 615,600 study of ALS

2004-05* NIH KO8 Principal Diet, gene-diet interactions and $ 122,647 Investigator risk of Parkinson’s

2005-10 NIH RO1 Co-Investigator NSAIDs, inflammation and $ 2,091,766 Parkinson’s disease

2006-11 NIH RO1 Consultant Prospective study of ALS: $ 1,497,423 Pooling project

2009-10 Parkinson Co-Principal Plasma cholesterol and the $ 12,000 Study Group Investigator progression of Parkinson’s disease

* Grant terminated when I took the NIEHS intramural position; cost for year 2004 only.

NIH Intramural Grants **

2007­ NIH ZO1 Principal The Parkinson’s Gene and $1,429,377 Investigator Environment (PAGE) Study

2009­ NIH ZO1 Principal The Shanghai Parkinson Study $ 658,179 Investigator

2009­ NIH ZO1 Principal Parkinson Research in the $ 393,070 Investigator Atherosclerosis Risks in

Communities (ARIC) Study

** Cost for data collection only.

Invited Presentations

Conference on Functional Genomics of Parkinson’s Disease and Beyond, Apr 18-20, 2013, Tübingen, Germany, “Environmental Risk Factors for Parkinson’s Disease”

Karolinska Institute, Nov 12, 2012, Stockholm, Sweden: “Parkinson’s Disease, Risk Factors and Premotor Symptoms”

International Congress on Neurology and Epidemiology, Nov 8-10, 2012, Nice, France: “Updates of Parkinson’s Epidemiology”

NIH Research Festival, Translational Research of Aging, Oct 10, 2012, Bethesda, MD, USA: “Prospective Research of Parkinson’s Premotor Symptoms”

The University of Mississippi Medical Center, Sep 17, 2012, Jackson, MS, USA: “Parkinson’s Premotor Symptoms – Clinical and Etiological Implications”

The Young Onset Parkinson Support Group, May 8, 2012, Cary, NC: “Current research on Parkinson’s disease”

Pennington Biomedical Research Center, Apr 27, 2012, Baton Rouge, LA, USA: “Environmental Epidemiology of Parkinson’s disease”

Tulane University, April 24, 2012, New Orleans, LA, USA: “Etiologic Research of Parkinson’s disease”

Centers for Neurodegeneration Sciences Program Directors Meeting, National Institute of Environmental Health Sciences, May 3, 2012, Research Triangle Park, NC, USA: “Findings from the Parkinson’s Genes and Environment Study”

Laboratory of Toxicology and Pharmacology Seminar Series, The National Institute of Environmental Health Sciences, Mar 15, 2012: “Parkinson’s Disease Etiological Research and Prevention”

Chinese Academy of Medical Sciences and Peking Union Hospital, Dec 29, 2011, Beijing, PR China: “Risk factors for Parkinson’s disease: beyond SNCA / MAPT and smoking/caffeine”

Chinese University of Hong Kong, School of Public Health and Primary Care, Dec 21, 2011, Hong Kong, China: “The Epidemiology of Parkinson’s Disease”

XIX World Congress on Parkinson´s Disease and Related Disorders, Dec 14, 2011, Shanghai, China: “Inflammation, NSAIDs use and Parkinson’s disease”

XIX World Congress on Parkinson´s Disease and Related Disorders, Dec 12, 2011, Shanghai, China: “What about Braak”

National Cancer Institute, Nov 30, 2011, Rockville, MD, USA: “Parkinson research in the NIH ­AARP Diet and Health cohort”

Grand Round Seminar, Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Sep 16, 2011, Hershey, PA, USA: “The Changing Landscape of Parkinson’s Epidemiology”

International Forum of Neurodegenerative Disease, Fu-Dan University Affiliated Hua-Shan Hospital, Jun 20, 2010, Shanghai, China: “Risk Factors for Parkinson´s disease: What Did We Learn in the Past Decade”

NIEHS Centers for Neurodegeneration Science Annual Meeting, Oct 8-9, 2009, Research Triangle Park, NC, USA: “The Parkinson’s Genes and Environment (PAGE) Study.”

The First International Congress on Clinical Neurology and Epidemiology, Aug 27-30, 2009, Munich, Germany: “Epidemiology of Parkinson's disease: new data and new methods”

National Institute of Environmental Health Sciences, Apr 7, 2009, Research Triangle Park, NC, USA: “Parkinson's Disease: Etiology, Clinical and Disability Management”

Institute for Nutritional Science, Chinese Academy of Sciences, Jun 3, 2008, Shanghai China: “Role of Diet in Parkinson’s Disease Development”

Shanghai Huashan Hospital, May 29, 2008, Shanghai, China: “Parkinson’s Disease: Gene and Environment”

Vanderbilt University, Nov 9, 2007, Nashville TN, USA: “Parkinson Epidemiology: Recent Progress and Research Opportunities”

Fourth Annual Parkinson’s Progress in 2007 Conference: Sep 28, 2007, Omaha, NE, USA: “Environmental Epidemiology of Parkinson's Disease”

Fourth Annual Parkinson’s Progress in 2007 Conference: Sep 28, 2007, Omaha, NE, USA: “Potential Environmental Contributors to Parkinson's Disease”

Consensus Meeting on Environment and Parkinson’s Disease: Jun 26-28, 2007, Sunnyvale, CA, USA: “Diet and Parkinson’s disease”

Roundtable Meeting on Exercise and Parkinson’s Disease: University of Pittsburgh, Jun 18, 2007, Pittsburgh, PA, USA: “Exercise and Parkinson’s disease – Epidemiological Findings”

North Carolina State University, Mar 20, 2007, Raleigh, NC, USA: “Parkinson’s disease: Is environment still relevant?”

Annual Conference on Rodent Genetics (Session Mediator): National Institute of Environmental Health Sciences, Sep 26, 2006, Research Triangle Park, NC, USA: “Gene-Environment Interactions in Parkinson's Disease”

Harvard School of Public Health, Jul 10, 2006. Boston, MA, USA: “Epidemiology of Parkinson’s disease: contributions from prospective studies”

Harvard School of Public Health, Oct 31, 2005. Boston, MA, USA: “Dairy consumption and risk of Parkinson’s disease”

Harvard School of Public Health, Mar 15, 2004, Boston, MA, USA: “Diet and Parkinson’s disease”

International Forum on the New Approaches to Understand Neuropsychological Diseases, Sep 3, 2004, Shanghai, China: “Environmental and genetic risk factors for Parkinson’s disease”

International Symposium on Parkinson’s disease, Sep 4-7, 2004, Beijing, China: “Obesity and the risk of Parkinson’s disease”

45th Annual Meeting of the American College of Nutrition, Sep 30–Oct 3, 2004, Long Beach, CA, USA: “Diet, Lifestyle, and Risk of Parkinson’s Disease”

Parkinson Institute, Nov 15, 2004, Sunnyvale, CA, USA: “Risk factors for Parkinson's disease: Findings from the Health Professionals Follow-up Study and the Nurses’ Health Study”

Reviewer for Journals

Annals of Internal Medicine American Journal of Epidemiology British Medical Journal Environmental Health Perspectives Lancet Epidemiology PLOS One Neuroepidemiology

Annals of Neurology American Journal of Clinical Nutrition Archives of Neurology British Journal of Nutrition Brain Behavior and Immunity Health and Aging Brain Research Journal of American College of Nutrition European Journal of Neurology Journal of Nutrition Expert Review of Neurotherapeutics American Journal of Physical Medicine & Journal of Alzheimer's Disease Rehabilitation Journal of Neurology, Neurosurgery & Diabetes Care Psychiatry Drugs & Aging Movement Disorders Journal of American Geriatric Society Neurology Neuroscience Letters Neurotoxicology Cancer Causes and Control Parkinsonisms and Related Disorders Cancer Research

Journal Editorial Boards 2009­ International Journal of Molecular Epidemiology and Genetics

(Associate Editorial Board) 2010­ American Journal of Epidemiology (Associate Editor) 2012­ American Journal of Neurodegenerative Disease (Associate Editorial Board)

Grant Reviews

National Institutes of Health Study Section: Neurological, Aging and Musculoskeletal Epidemiology

Parkinson’s Disease Society, United Kingdom Austrian Science Fund, Austria Parkinson Study Group (PSG), United States and Canada The Wellcome Trust Center for Environmental Health and Susceptibility, UNC School of Public Health The Prinses Beatrix Fonds, Netherlands Neurological Foundation of New Zealand Association of British Neurologists

Other Professional Services

Organizer, Symposium on Parkinson’s premotor symptoms – clinical and etiological implications, Jun 7-8, 2012, Research Triangle Park, NC, USA

Expert Panel on Global Burden of Diseases, Gates Foundation / World Health Organization Scientific Committee, International Congress on Neurology and Epidemiology, Nov 8-10,

2012, Nice, France Co-Chair, “Epilepsy & Neurodegenerative disorders”, Nov 9, 2012, Nice, France Scientific Committee, The Parkinson Study Group (PSG, 2012-2015) Co-Chair, “Parkinson’s disease and other movement disorders - Epidemiology and

Management Part 1 and Part 2.” The First International Congress on Clinical Neurology and Epidemiology, Aug 27-30, 2009, Munich, Germany

Scientific Committee, First International Congress on Clinical Neurology and Epidemiology, Aug 27-30, 2009, Munich, Germany

Scientific Committee, Wuhan International Conference on the Environment & the 2009 Annual Meeting of Chinese Society for Environmental Sciences, Jun 2009

National Institute of Environmental Health Sciences/National Toxicology Program Scientific Review Group

DIR Committee for Distinguished Lecturers and Scientific Conferences, National Institute of Environmental Health Sciences

Sister Study Steering Committee, National Institute of Environmental Health Sciences Society for Epidemiologic Research Award Committee Judge, Fellow Awards for Research Excellence, National Institutes of Health Meeting abstract reviewer for Society for Epidemiologic Research annual meeting Meeting abstract reviewer for International Congress on Clinical Neurology and

Epidemiology

Mentoring

Name Position Years Current Position

Past:

Dr. Qun Xu Visiting Fellow 2007-09 Professor, Chinese Academy of Medical Sciences

Dr. Jianjun Gao Visiting Fellow 2008-12 Data Analyst, University of Chicago

Current: Jessica Rinsky Summer Student, 2010- Ph.D. candidate, University of North

Special Volunteer Carolina at Chapel Hill Edward Zhao Summer Student, 2010- High School Student, North Carolina School

Special Volunteer of Sciences and Mathematics, Durham Dr. Rui Liu IRTA Fellow 2010­

Dr. Wen Zhang Visiting Fellow 2012­

Dr. Jing Dong Visiting Fellow 2012­

Patent

Payami H, Hamza T, Factor S, Nutt J, Chen H, and Zabetian C: Provisional US patent # PCT/US2011/000702: Method of identifying and treating a patient having a predisposition to or afflicted with Parkinson disease

Bibliography

A. Peer-Reviewed Original Publications

1 Chen H, Ge KY, Wang EL, Jia FM, Jiao RH, Wang YY: The validation of conjunctival impression cytology to detect vitamin A deficiency. Hygiene Res 25(Suppl):126-132, 1996.

2 Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PWF, Kiel D: Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69(4):727-36, 1999. PMID: 10197575

3 Tucker KL, Chen H, Vogel S, Wilson PW, Schaefer EJ, and Lammi-Keefe CJ: Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population. J Nutr 129(2):438-45, 1999. PMID: 10024624

4 Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B, Kiel DP: Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71(5):1201-8, 2000 (with editorial). PMID: 10799384

5 Chen H, Burmudez OI, Tucker KL: Waist circumference and weight change are associated with disability among elderly Hispanics. J Gerontol A Biol Sci Med Sci 57(1): M19-25, 2002. PMID: 11773208

6 Chen H, Ward MH, Graubard BI, Heineman EF, Markin RM, Potischman NA, Russell RM, Weisenburger DD, Tucker KL: Dietary patterns and adenocarcinoma of the esophagus and distal stomach. Am J Clin Nutr 75(1):137-44, 2002 (with editorial and press release). PMID: 11756071

7 Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PW, Felson D, Kiel DP: Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr 76(1):245-52, 2002. PMID: 12081842

8 Chen H, Tucker KL, Graubard BI, Heineman EF, Markin RS, Potischman NA, Russell RM, Weisenburger DD, Ward MH: Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer 42(1):33-40, 2002. PMID: 12235648

9 Chen H, Ward MH, Tucker KL, Graubard BI, McComb RD, Potischman NA, Weisenburger DD, Heineman EF: Diet and risk of adult glioma in eastern Nebraska, United States. Cancer Causes Control 13(7):647-55, 2002. PMID: 12296512

10 Zhang SM, Hernán MA, Chen H, Spiegelman D, Willett WC, Ascherio A: Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 59(8): 1161-9, 2002 (with editorial). PMID: 12391343

11 Chen H, Zhang SM, Hernán MA, Willett WC, Ascherio A: Diet and Parkinson’s disease: a potential role of dairy products in men. Ann Neurol 52(6):793-801, 2002. PMID: 12447934

12 Chen H, Zhang SM, Hernán MA, Willett WC, Ascherio A: Weight loss in Parkinson’s disease. Ann Neurol 53(5):676-9, 2003. PMID: 12731005

13 Chen H, Miller BA, Giovannucci E, Hayes RB: Height and the survival of prostate cancer patients. Cancer Epidemiol Biomarkers Prev 12(3):215-8, 2003. PMID: 12646510

14 Ascherio A, Chen H, Schwarzschild MA, Zhang SM, Colditz GA, Speizer FE: Caffeine, postmenopausal estrogen, and risk of Parkinson's disease. Neurology 60(5): 790-5, 2003. PMID: 12629235

15 Chen H, Zhang SM, Hernán MA, Willett WC, Ascherio A: Dietary intakes of fat and risk of Parkinson’s disease. Am J Epidemiol 157(11):1007-14, 2003. PMID: 12777364

16 Weisskopf MG, Chen H, Schwarzschild MA, Kawachi I, Ascherio A: Prospective study of phobic anxiety and risk of Parkinson's disease. Mov Disord 18(6):646-51, 2003. PMID: 12784267

17 Chen H, Zhang SM, Hernán MA, Schwarzschild MA, Willett WC, Colditz GA, Speizer FE, Ascherio A: Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Arch Neurol 60:1059-64, 2003 (with editorial and press release). PMID: 12925360

18 Hernán MA, Chen H, Schwarzschild MA, Ascherio A: Alcohol consumption and the incidence of Parkinson's disease Ann Neurol 54(2):170-5, 2003. PMID: 12891669

19 Chen H, Zhang SM, Schwarzschild MA, Hernán MA, Willett WC, Ascherio A: Obesity and the risk of Parkinson’s disease. Am J Epidemiol 159(6):547-55, 2004. PMID: 15003958

20 Chen H, Zhang SM, Schwarzschild MA, Hernán MA, Logroscino G, Willett WC, Ascherio A: Folate intake and risk of Parkinson’s disease. Am J Epidemiol 160(4):368-75, 2004. PMID:15286022

21 Zhang J, Song YQ, Chen H, Fan D: The tau gene haplopyte h1 confers a susceptibility to Parkinson’s disease. Euro Neurol 53(1):15-21, 2005. PMID: 15627775

22 Chen H, Zhang SM, Schwarzschild MA, Hernán MA, Ascherio A: Physical activity and the risk of Parkinson’s disease. Neurology 64(4):664-9, 2005 (with journal highlight). PMID: 15728289

23 Chen H, Jacobs E, Schwarzschild MA, McCullough ML, Calle EE, Thun MJ, Ascherio A: Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol 58(6) 963-7, 2005. PMID: 16240369

24 Jiang B, Wang WZ, Chen H, Hong Z, Yang QD, Wu SP, Du XL, Bao QJ: Incidence and trends of stroke and its subtypes in China: results from three large cities. Stroke 37(1):63-8, 2006. PMID: 16306469

25 Chen H, Schernhammer E, Schwarzschild MA, Ascherio A: A prospective study of night shift work, sleep duration, and risk of Parkinson’s disease. Am J Epidemiol 163(8):726­30, 2006. PMID: 16495472

26 Chen H, Zhang SM, Schwarzschild MA, Hernán MA, Ascherio A: Survival of Parkinson's disease patients in a large prospective cohort of male health professionals. Mov Disord 21(7): 1002-7, 2006. PMID: 16602107

27 Logroscino G, Chen H, Wing A, Ascherio A: Blood donations, iron stores, and risk of Parkinson’s disease. Mov Disord 21(6):835-8, 2006. PMID: 16802290

28 Ascherio A, Chen H, Weisskopf MG, O’Reilly E, McCullough ML, Calle EE, Schwarzschild MA, Thun MJ: Pesticide exposure and risk for Parkinson’s disease. Ann Neurol 60 (2): 197-203, 2006 PMID: 16802290

29 Huang X, Chen H, Miller WC, Mailman RB, Woodard JL, Chen PC, Xiang D, Murrow RW, Wang YZ, Poole C: Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord 22(3):377-81, 2007. PMID: 17177184; PMCID: PMC1906875

30 Thacker EL, O'Reilly EJ, Weisskopf MG, Chen H, Schwarzschild MA, McCullough ML, Calle EE, Thun MJ, Ascherio A: Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 68(10): 764-8, 2007. PMID: 17339584; PMCID: PMC2225169

31 Chen H, O'Reilly E, McCullough ML, Rodriguez C, Schwarzschild MA, Calle EE, Thun MJ, Ascherio A: Consumption of dairy products and risk of Parkinson's disease. Am J Epidemiol 165(9):998-1006, 2007. PMID: 17272289; PMCID: PMC2232901

32 Kan H, London SJ, Chen H, Song G, Chen G, Jiang L, Zhao N, Zhang Y, Chen B: Diurnal temperature range and daily mortality in Shanghai, China. Environ Res 103(3):424-31, 2007. PMID: 17234178

33 Chen H, Richard M, Sandler DP, Umbach DM, Kamel F: Head injury and amyotrophic lateral sclerosis. Am J Epidemiol 166(7):810-6, 2007. PMID: 17641152; PMCID: PMC2239342

34 Weisskopf MG, O’Reilly E, Chen H, Schwarzschild MA, Ascherio A: Plasma urate and risk of Parkinson’s disease. Am J Epidemiol 166(5):561-7, 2007. PMID:17584757; PMCID: PMC2391073

35 Simon KC, Chen H, Schwarzschild MA, Ascherio A: Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson’s disease. Neurology 69(17):1688-95, 2007. PMID: 17761552; PMCID: PMC2391077

36 Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, Ascherio A: Prospective study of dietary pattern and risk of Parkinson disease. Am J Clin Nutr 86(5):1486-94, 2007. PMID: 17991663; PMCID: PMC222516

37 Gao X, Chen H, Schwarzschild MA, Glasser DB, Logroscino G, Rimm EB, Ascherio A: Erectile function and risk of Parkinson’s disease. Am J Epidemiol 166(12):1446-50, 2007. PMID: 17875583; PMCID: PMC2385785

38 Chen H, O’Reilly EJ, Schwarzschild MA, Ascherio A: Peripheral inflammatory biomarkers and risk of Parkinson’s disease. Am J Epidemiol 167(1):90-5, 2008. PMID: 17890755.

39 Wang H, Chen H, Gao X, McGrath M, Deer D, De Vivo I, Schwarzschild MA, Ascherio A: Telomere length and risk of Parkinson’s diseases. Mov Disord 23(2):302-5, 2008. PMID: 18044760; PMCID: PMC2387100

40 Thacker EL, Chen H, Patel AV, McCullough ML, Calle EE, Thun MJ, Schwarzschild MA, Ascherio A: Recreational physical activity and risk of Parkinson’s disease. Mov Disord 23(1):69-74, 2008. PMID: 17960818; PMCID: PMC2387117

41 Gao X, Chen H, Schwarzschild MA, Logroscino G, Ascherio A: Perceived imbalance and risk of Parkinson’s disease. Mov Disord 23(4):613-6, 2008. PMID: 18181208; PMCID: PMC2385782

42 Chen H, Guo X: Obesity and functional disability in elderly Americans. J Am Geriatr Soc 56(4):689-94, 2008. PMID: 18266843; PMCID: PMC2391089

43 Gao X, Chen H, Choi HK, Curhan G, Schwarzschild MA, Ascherio A: Diet, Urate and Parkinson’s disease risk in men. Am J Epidemiol 167(7):831-8, 2008. PMID: 18326873; PMCID: PMC2367211

44 Logroscino G, Gao X, Chen H, Wing A, Ascherio A: Dietary iron intake and risk of Parkinson’s disease. Am J Epidemiol 168(12):1381-8, 2008. PMID: 18945687; PMCID: PMC2727188

45 O’Reilly EJ, Chen H, Gardener H, Gao X, Schwarzschild MA, Ascherio A: Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality. Am J Epidemiol 169(6):678-82, 2009. PMID: 19131566; PMCID: PMC2727210

46 Kim S, Parks CG, DeRoo LA, Chen H, Taylor JA, Cawthon RM, Sandler DP: Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev 18(3):816-20, 2009. PMID: 19273484; PMCID: PMC2805851

47 Xu Q, Parks CG, DeRoo LA, Cawthon RM, Sandler DP, Chen H: Multivitamin use and telomere length in women. Am J Clin Nutr 89(6):1857-63, 2009 (with editorial and press release). PMID: 19279081; PMCID: PMC2714373

48 Chen H, Mosley TH, Alonso A, Huang X: Plasma urate and Parkinson’s disease in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 169(9):1064-9, 2009. PMID: 19299404; PMCID: PMC2727240

49 Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wüllner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Gasser T: SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 65(5):610-4, 2009. PMID: 19475667; PMCID: PMC3520128

50 Simon KC, Chen H, Gao X, Schwarzschild MA, Ascherio A: Reproductive factors exogenous estrogen use, and risk of Parkinson’s disease. Mov Disord 24(9):1359-65, 2009. PMID: 19424986; PMCID: PMC2751573

51 Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J * , Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T: Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics 41(12):1308-12, 2009 (with editorial) PMID: 19915575; PMCID: PMC2787725

52 Xu Q * , Song Y, Hollenbeck A, Blair A, Schatzkin A, Chen H: Day napping and short night sleeping are associated with higher risk of diabetes in older adults. Diabetes Care 33(1):78-83, 2010. PMID: 19825823; PMCID: PMC2797990

53 Chen H, Huang X, Guo X, Mailman RB, Park Y, Kamel F, Umbach DM, Xu Q * , Hollenbeck A, Schatzkin A, Blair A: Smoking duration, intensity, and risk of Parkinson disease. Neurology 74 (11): 878-84, 2010 (with editorial and press release) PMID: 20220126; PMCID: PMC2836869.

54 Fang F*, Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Kamel F, Chen H: Depression and the subsequent risk of Parkinson’s disease in the NIH-AARP Diet and Health Study. Mov Disord 25(9):1157-62, 2010 PMID: 20310050; PMCID: PMC2914462

55 Xu Q * , Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H: Physical activities and future risk of Parkinson disease. Neurology 75(4):341-8, 2010 (with journal highlight) PMID: 20660864; PMCID: PMC2918886.

56 Gardener H, Gao X, Chen H, Schwarzschild MA, Spiegelman D, Ascherio A: Prenatal and early life factors and risk of Parkinson’s disease. Mov Disord 25(11):1560-7, 2010 PMID: 20740569; PMCID: PMC3132935

57 Simon KC, Gao X, Chen H, Schwarzschild MA, Ascherio A: Calcium channel blocker use and risk of Parkinson’s disease. Mov Disord 25(12):1818-22, 2010 PMID: 20669249 PMCID: PMC2939261

58 O’Reilly EJ, Gao X, Weisskopf MG, Chen H, Schwarzschild MA, Spiegelman D, Ascherio A: Plasma urate and Parkinson’s disease in women. Am J Epidemiol 172(6):666-70, 2010 PMID: 20682521 PMCID: PMC2950819

59 Gao X, Chen H, Schwarzschild MA, Ascherio A: Use of ibuprofen and risk of Parkinson disease. Neurology 76(10):863-9, 2011 (with editorial) PMID: 21368281; PMCID: PMC3059148

60 Song Y, Xu Q * , Park Y, Hollenbeck A, Schatzkin A, Chen H: Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U.S. adults. Diabetes Care 34(1):108-14, 2011 PMID: 20978095 PMCID: PMC3005464

61 Ma W, Chen H, Jiang L, Song G, Kan H: Stock volatility as a risk factor for coronary heart disease death. European Heart J 32(8): 1006-11, 2011 PMID: 21196446; PMCID: PMC3076666

62 Gao J * , Xu H, Weinberg C, Huang X, Park Y, Hollenbeck A, Blair A, Schatzkin A, Burch L, Chen H: An Exploratory Study on the CHRNA3-CHRNA5-CHRNB4 Cluster, Smoking, and Parkinson's Disease. Neurodegener Dis 8(5):296-9, 2011 PMID: 21228559; PMCID: PMC3121544

63 Gao J * , Huang X, Park Y, Hollenbeck A, Blair A, Schatzkin A, Chen H: Daytime napping, nighttime sleeping, and Parkinson disease. Am J Epidemiol 173(9):1032-8, 2011 PMID: 21402730; PMCID: PMC3121222.

64 Xu Q * , Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H: Diabetes and risk of Parkinson’s disease. Diabetes Care 34(4):910-5, 2011 PMID: 21378214; PMCID: PMC3064050

65 International Parkinson Disease Genomics Consortium: Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 377(9766): 641-9 (with editorial) PMID: 21292315

66 Liu R * , Gao X, Lu Y, Chen H: Meta-analysis of the relationship between Parkinson disease and melanoma. Neurology 76 (23): 2002-9, 2011 (with journal highlight and press release) PMID: 21646627; PMCID: PMC3116643

67 Gao X, Chen H, Schwarzschild MA, Ascherio A: A prospective study of bowel movement frequency and risk of Parkinson’s disease. Am J Epidemiol 174(5):546-51, 2011 PMID: 21719744; PMCID: PMC3202149

68 International Parkinson’s Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2): A two-stage meta-analysis identifies several new loci for Parkinson’s disease. PLoS Genet 7(6): e1002142, 2011 PMID: 21738488; PMCID: PMC3128098

69 Gao J * , Huang X, Park Y, Liu R, Hollenbeck A, Schatzkin A, Mailman RB, Chen H: Apolipoprotein E genotypes and the risk of Parkinson disease. Neurobio Aging 32(11):2106.e1-6, 2011 PMID: 21741729 PMCID: PMC3172377

70 Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, Montimurro J, Kay DM, Tenesa A, Kusel VI, Sheehan P, Eaaswarkhanth M, Yearout D, Roberts J, Agarwal P, Bordelon Y, Park Y, Wang L, Gao J * , Vance JM, Kendler KS, Scott W, Ritz B, Nutt J, Factor SA, Zabetian CP, Payami H: Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson’s disease modifier gene via interaction with coffee. PLoS Genet 7(8):e1002237, 2011 PMID: 21876681 PMCID: PMC3158052

71 Huang X, Auinger P, Eberly S, Oakes D, Schwarzschild M, Ascherio A, Mailman R, Chen H; Parkinson Study Group DATATOP Investigators: Serum cholesterol and the progression of Parkinson’s disease: results from DATATOP. PLoS One 6(8):e22854, 2011 PMID: 21853051 PMCID: PMC3154909

72 Gao J * , Huang X, Park Y, Hollenbeck A, Chen H: An exploratory study on CLU, CR1 and PICALM and Parkinson disease. PLoS One 6(8):e24211, 2011. PMID: 21912625; PMCID: PMC3166161

73 Fang F, Chen H, Wirdefeldt K, Ronnevi LO, Al-Chalabi A, Peters TL, Kamel F, Ye W: Infections of the central nervous system, sepsis and amyotrophic lateral sclerosis PLoS One 6(12):e29749 2011. PMID: 22216353; PMCID: PMC3246484

74 Meng S, Song F, Chen H, Gao X, Amos CI, Lee JE, Wei Q, Qureshi AA, Han J: No Association between Parkinson Disease Alleles and the Risk of Melanoma. Cancer Epidemiol Biomarkers Prev 21(1):243-5 2012. PMID: 22086882; PMCID: PMC3253945

75 Wen HB, Zhang ZX, Wang H, Li L, Chen H, Liu Y, Zhang B, Xu Q: Epidemiology and clinical phenomenology for Parkinson's disease with pain and fatigue. Parkinsonism & Related Disorders 18 (Suppl 1):S222-5, 2012;PMID: 22166441; NIHMS459812

76 Liu R * , Guo X, Park Y, Huang X, Sinha R, Freedman ND, Hollenbeck A, Blair A, Chen H: Caffeine Intake, Smoking, and Risk of Parkinson Disease in Men and Women Am J Epidemiol 175(11):1200-7, 2012; PMID: 22505763; PMCID: PMC3370885

77 Fang F, Wirdefeldt K, Jacks A, Kamel F, Ye W, Chen H: CNS Infections, sepsis, and the risk for Parkinson’s disease. Int J Epidemiol 41(4):1042-9. 2012; PMID: 22523201; PMCID: PMC3429872

78 Du G, Lewis M, Shaffer M, Chen H, Yang Q, Mailman R, Huang X: Serum cholesterol and nigrostriatal R2* values in Parkinson's disease PLoS One 7(4):e35397, 2012 PMID: 22530017; PMCID: PMC3328461

79 Gao J * , Nalls M, Shi M, Joubert B, Hernandez D, Huang X, Hollenbeck A, Singleton A, Chen H: An exploratory analysis on gene-environment interactions for Parkinson disease. Neurobio Aging 33(10):2528.e1-6, 2012. PMID: 22763023 PMCID: PMC3419385

80 Hu G, Horswell R, Wang Y, Besse J, Xiao K, Chen H, Heymsfield SB, Ryan DIET AND HEALTH, Katzmarzyk PT: Body mass index and the risk of dementia among Louisiana middle and low income diabetic patients. PLoS One 7(9): e44537, 2012. PMID: 22957079; PMCID: MC3434129

81 International Parkinson's Disease Genomics Consortium (IPDGC) and The Wellcome Trust Case Control Consortium 2 (WTCCC2): Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet 21(22): 4996­5009, 2012. PMID: 22892372; PMCID: PMC3576713

82 Fang F, Chen H, Feldman A, Kamel F, Ye W, Wirdefeldt K: Head injury and Parkinson’s disease: A population-based study. Mov Disord 27(13):1632-5, 2012. (with editorial). PMID: 23143933

83 Mittag F, Büchel F, Saad M, Jahn A, Schulte C, Bochdanovits Z, Simón-Sánchez J, Nalls MA, Keller M, Hernandez DG, Gibbs JR, Lesage S, Brice A, Heutink P, Martinez M, Wood NW, Hardy J, Singleton AB, Zell A, Gasser T, Sharma M; International Parkinson’s Disease Genomics Consortium: Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities. Hum Mutat 33(12):1708-18, 2012. PMID: 22777693

84 Holmans P, Moskvina V, Jones L, Sharma M; The International Parkinson's Disease Genomics Consortium (IPDGC), Vedernikov A, Buchel F, Sadd M, Bras JM, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Gibbs JR, Schulte C, Durr A, Guerreiro R, Hernandez D, Brice A, Stefánsson H, Majamaa K, Gasser T, Heutink P, Wood NW, Martinez M, Singleton AB, Nalls MA, Hardy J, Morris HR, Williams NM. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Hum Mol Genet 22(5):1039-49, 2013; PMID: 23223016; PMCID: PMC3561909

85 Zhang G, Ding H, Chen H, Ye X, Li H, Lin X, Ke Z: Association of thiamine nutritional status and depressive symptoms among older Chinese adults J Nutr 143(1):53-8, 2013. PMID:23173173; PMCID: PMC3521461

86 Global Burden of Diseases Study Group: Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen JS, Cheng AT, Child JC, Cohen A, Colson KE, Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane MM, Flaxman S, Fowkes FG, Freedman G, Freeman MK, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD 3rd, Hoy D, Hu H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R, Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang YH, Khatibzadeh S, Khoo JP, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Mensah GA, Merriman TR, Micha R, Michaud C, Mishra V, Hanafiah KM, Mokdad AA, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson PK, Nolla JM, Norman R, Olives C, Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CD, Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M, Phillips MR, Pope D, Pope CA 3rd, Powles J, Rao M, Razavi H, Rehfuess EA, Rehm JT, Ritz B, Rivara FP, Roberts T, Robinson C, Rodriguez-Portales JA, Romieu I, Room R, Rosenfeld LC, Roy A, Rushton L, Salomon JA, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh GM, Sleet DA, Smith E, Smith KR, Stapelberg NJ, Steenland K, Stöckl H, Stovner LJ, Straif K, Straney L, Thurston GD, Tran JH, Van Dingenen R, van Donkelaar A, Veerman JL, Vijayakumar L, Weintraub R, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams W, Wilson N, Woolf AD, Yip P, Zielinski JM, Lopez AD, Murray CJ, Ezzati M, AlMazroa MA, Memish ZA: A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859): 2224-60, 2013. PMID: 23245609

87 Global Burden of Diseases Study Group: Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, Memish

ZA: Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197-223, 2013. PMID:23245608

88 Global Burden of Diseases Study Group: Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H,

Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA: Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2163-96, 2013. PMID: 23245607

89 Global Burden of Diseases Study Group: Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, Begum N, Shah R, Karyana M, Kosen S, Farje MR, Moncada G, Dutta A, Sazawal S, Dyer A, Seiler J, Aboyans V, Baker L, Baxter A, Benjamin EJ, Bhalla K, Bin Abdulhak A, Blyth F, Bourne R, Braithwaite T, Brooks P, Brugha TS, Bryan-Hancock C, Buchbinder R, Burney P, Calabria B, Chen H, Chugh SS, Cooley R, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, Davis A, Degenhardt L, Díaz-Torné C, Dorsey ER, Driscoll T, Edmond K, Elbaz A, Ezzati M, Feigin V, Ferri CP, Flaxman AD, Flood L, Fransen M, Fuse K, Gabbe BJ, Gillum RF, Haagsma J, Harrison JE, Havmoeller R, Hay RJ, Hel-Baqui A, Hoek HW, Hoffman H, Hogeland E, Hoy D, Jarvis D, Karthikeyan G, Knowlton LM, Lathlean T, Leasher JL, Lim SS, Lipshultz SE, Lopez AD, Lozano R, Lyons R, Malekzadeh R, Marcenes W, March L, Margolis DJ, McGill N, McGrath J, Mensah GA, Meyer AC, Michaud C, Moran A, Mori R, Murdoch ME, Naldi L, Newton CR, Norman R, Omer SB, Osborne R, Pearce N, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Pourmalek F, Prince M, Rehm JT, Remuzzi G, Richardson K, Room R, Saha S, Sampson U, Sanchez-Riera L, Segui-Gomez M, Shahraz S, Shibuya K, Singh D, Sliwa K, Smith E, Soerjomataram I, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Taylor HR, Tleyjeh IM, van der Werf MJ, Watson WL, Weatherall DJ, Weintraub R, Weisskopf MG, Whiteford H, Wilkinson JD, Woolf AD, Zheng ZJ, Murray CJ, Jonas JB: Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet 380(9859):2129-43, 2013. PMID: 23245605

90 Global Burden of Diseases Study Group: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin Abdulhak A, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, De Leo D, Degenhardt L, Delossantos A, Denenberg J, Des Jarlais DC, Dharmaratne SD, Dorsey ER, Driscoll T, Duber H, Ebel B, Erwin PJ, Espindola P, Ezzati M, Feigin V, Flaxman AD, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabriel SE, Gakidou E, Gaspari F, Gillum RF, Gonzalez-Medina D, Halasa YA, Haring D, Harrison JE, Havmoeller R, Hay RJ, Hoen B, Hotez PJ, Hoy D, Jacobsen KH, James SL, Jasrasaria R, Jayaraman S, Johns N, Karthikeyan G, Kassebaum N, Keren A, Khoo JP, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lipnick M, Lipshultz SE, Ohno SL, Mabweijano J, MacIntyre MF, Mallinger L, March L, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGrath J, Mensah GA, Merriman TR, Michaud C, Miller M, Miller TR, Mock C, Mocumbi AO, Mokdad AA, Moran A, Mulholland K, Nair MN, Naldi L, Narayan KM, Nasseri K, Norman P, O'Donnell M, Omer SB, Ortblad K, Osborne R, Ozgediz D, Pahari B, Pandian JD, Rivero AP, Padilla RP, Perez-Ruiz F, Perico N, Phillips D, Pierce K, Pope CA 3rd, Porrini E, Pourmalek F, Raju M, Ranganathan D, Rehm JT, Rein DB, Remuzzi G, Rivara FP, Roberts T, De León FR, Rosenfeld LC, Rushton L, Sacco RL, Salomon JA, Sampson U, Sanman E, Schwebel DC, Segui-Gomez M, Shepard DS, Singh D, Singleton J, Sliwa K, Smith E, Steer A, Taylor JA, Thomas B, Tleyjeh IM, Towbin JA, Truelsen T, Undurraga EA,

Venketasubramanian N, Vijayakumar L, Vos T, Wagner GR, Wang M, Wang W, Watt K, Weinstock MA, Weintraub R, Wilkinson JD, Woolf AD, Wulf S, Yeh PH, Yip P, Zabetian A, Zheng ZJ, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2095-128 2013. PMID: 23245604

91 Klebe S, Golmard JL, Nalls MA, Saad M, Singleton AB, Bras JM, Hardy J, Simon-Sanchez J, Heutink P, Kuhlenbäumer G, Charfi R, Klein C, Hagenah J, Gasser T, Wurster I, Lesage S, Lorenz D, Deuschl G, Durif F, Pollak P, Damier P, Tison F, Durr A, Amouyel P, Lambert JC, Tzourio C, Maubaret C, Charbonnier-Beaupel F, Tahiri K, Vidailhet M, Martinez M, Brice A, Corvol JC; French Parkinson's Disease Genetics Study Group and the International Parkinson's Disease Genomics Consortium (IPDGC): The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. J Neurol Neurosurg Psychiatry 2013 Feb 13. [Epub ahead of print] PMID:2340806

92 Gao J, Xu H, Huang X, Chen H: Short communication: Genetic variations of SLC2A9 in relation to Parkinson's disease Transl Neurodegener 2013 Feb 19;2(1):5. [Epub ahead of print]. PMID: 23422251; PMCID: PMC3598344

93 Liu R, Guo X, Park Y, Wang J, Huang X, Hollenbeck A, Blair A, Chen H: Alcohol consumption, types of alcohol, and Parkinson’s disease. PLoS One (in press)

B. Original Contributions under Review or Ready for Submission

94 Guo X, Park Y, Freedman ND, Sinha R, Hollenbeck A, Blair A, Chen H: Sweetened beverages, coffee, and tea in relation to depression among older US adults (in review)

95 Liu R, Baird D, Park Y, Freedman N, Huang X, Hollenbeck A, Blair A, Chen H: Female reproductive factors, postmenopausal hormone use, and Parkinson’s disease. (in review)

96 Rinsky JL, Hoppin JA, Blair A, He K, Beane-Freeman LE, Chen H: Agricultural exposures and stroke mortality in the Agricultural Health Study. (in review)

97 Wirdefeldt K, Weibull CE, Chen H, Kamel F, Lundholm C, Fang F, Ye W: Parkinson’s disease and cancer: A register-based family study. (in review)

98 Zhang ZX, Chen H, Xu Q, Chen SD, Sun SG, Shao M, Qu QM, Zhang BR, Liu YM, Liu ZG, Chen HB, Jiang YP, Wang J, Yang ZJ, Chen X, Wen HB: Clinical features and associated factors in 901 patients with Parkinson’s disease across four economic-regions of China. (in review)

99 Kamel F, Goldman SM, Umbach DM, Chen H, Richardson G, Barber MR, Meng C, Marras C, Korell M, Kasten M, Hoppin JA, Comyns K, Chade A, Blair A, Bhudhikanok GS, Ross GW, Langston JW, Sandler DP, Tanner CM: Dietary fat intake, pesticide use, and Parkinson’s disease. (in review)

100 Kirrane E, Bowman C, Davis JA, Hoppin JA, Blair A, Chen H, Patel M, Sandler DP, Tanner CM, Vinikoor-Imler L, Ward M, Luben TJ, Kamel F. Associations of long-term average ozone and PM2.5 concentrations with Parkinson’s disease among participants in the Agricultural Health Study. (ready for submission)

101 Gao J, Staub H, Zhao E, Huang X, Nalls M, Singleton A, Chen H: Head injury, potential interactions with genes and the risk for Parkinson’s disease. (ready for submission)

C. Peer-Reviewed Reviews

102 Chen H and Ge KY: Update of the methods to detect vitamin A deficiency. J Int Med: Hyg Sect 24(2): 106-109. 1997

103 Ascherio A and Chen H: Caffeinated clues from epidemiology of Parkinson’s disease Neurology 61 (11 Suppl 6): S51-S54, 2003. PMID: 14663011

104 Schernhammer E, Chen H, Ritz B: Circulating melatonin: A possible link between Parkinson’s disease and cancer risk. Cancer Causes Control 17(4):577-82, 2006. PMID: 16596313

105 Bronstein J, Carvey P, Chen H, Cory-Slechta D, Dimonte D, Duda J, English P, Goldman S, Grate S, Hansen J, Hoppin J, Jewell S, Kamel F, Koroshetz W, Langston JW, Logroscino G, Nelson L, Ravina B, Rocca W, Ross GW, Schettler T, Schwarzschild M, Scott B, Seegal R, Singleton A, Steenland K, Tanner CM, Van Den Eeden S, Weisskopf MC: Meeting Report: Consensus Statement-Parkinson's Disease and the Environment: Collaborative on Health and the Environment and Parkinson's Action Network (CHE PAN) Conference 26-28 June 2007. Environ Health Perspect 117(1):117­21, 2009. PMID: 19165397; PMCID: PMC2627854

106 Hancock DB, Scott WK, Chen H: Pesticide exposure and Parkinson’s disease. US Neurology 4 (2) 48-50, 2009

107 Chen H, Huang X: Environmental Epidemiology of Sporadic Parkinson’s Disease. N Am J Med Sci 3(2):73-78, 2010

108 Block M, Elder A, Auten R, Bilbo S, Chen H, Chen JC, Cory-Slechta D, Costa D, Diaz-Sanchez D, Doorman D, Gold D, Gray K, Jeng HA, Kaufman J, Kleinman M, Kirshner A, Lawler C, Miller DS, Nadadur S, Ritz B, Semmens E; Tonelli L, Veronesi B, Wright R, Wright R: The Outdoor Air Pollution and Brain Health Workshop. Neurotoxicol 33(5):972­84, 2012. PMID: 22981845

D. Correspondences

109 Weisskopf MG, O'Reilly E., Chen H, Schwarzschild MA, and Ascherio A: Reply: Plasma urate and risk of Parkinson's disease. Am J Epidemiol 167(6):753-4, 2008. PMID: 18283033

110 Huang X, Chen H, Petrovitch H, Mailman R, Ross W: Reply: Plasma cholesterol and Parkinson's disease: is the puzzle only apparent? Mov Disorders 25(1):137, 2010. PMID: 20077471

111 Chen H., Kamel F., Park Y, Hollenbeck A. Huang X: Reply: Smoking duration, intensity, and risk of Parkinson disease. Neurology 75(6):574-5, 2010. PMID: 20697113

112 Chen H, Gao X, Ascherio A: Prospective research on Parkinson nonmotor symptoms. Arch Neurology 68(1):137, 2011. PMID: 21220690

E. Other

113 Chen H: Smoking duration, intensity, and Parkinson’s disease. Focus on Parkinson’s Disease 22(1):16-18, 2011 (Invited extended abstract, originally in Neurology 74(11):878-84, 2010)

114 Chen H: Physical activity and future risk of Parkinson’s disease. Focus on Parkinson’s Disease 22(1):19-21, 2011 (Invited extended abstract, originally in Neurology 75(4):341­8, 2010)