Curriculum Vitae Name: Ernst-Jan M. Speel date: 27-02-2018 ......6. Teaching experience Regular courses per faculty, University of Maastricht and MUMC Faculty of Health, Medicine and

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Curriculum Vitae Name: Ernst-Jan M. Speel date: 27-02-2018 1. Personal details: Full Name: Ernst-Jan Maria Speel Living address: Graaf de Liedekerkestraat 1, 6245 BE Eijsden, The Netherlands Phone: +31-43-4091111 / Mobile: +31-6-24959185 Date and place of birth: 21-09-1964, ‘s-Hertogenbosch, The Netherlands Nationality: Dutch Sex: Male Mariatal status: Married with Evelien Flierman, 3 daughters 2. Professional address: Name University: Maastricht University Medical Center (MUMC) Name Institute: GROW-School for Oncology & Developmental Biology Department: Pathology Laboratory: Unit Molecular Oncopathology & Diagnostics Post address: P.O. Box 5800, 6202 AZ Maastricht, The Netherlands Phone: +31-43-3874614/6610 Fax: +31-43-3876613 E-mail: [email protected] 3. Training / Education (including graduation) 1976-1982 Secondary School (Atheneum B), Oss, The Netherlands 1982-1988 Study Biology (Propedeuse 1983, MSc 1988) University of Nijmegen, Nijmegen, The Netherlands 1989-1995 PhD student University of Maastricht, Maastricht, The Netherlands 20-04-1995 PhD thesis:

”Detection systems for multiple-target in situ hybridization and immunocytochemistry”

Promotor: Prof. Dr. F.C.S. Ramaekers Co-promotor: Dr. A.H.N. Hopman

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4. Professional appointments Employment history and functions 1989-1990 Research fellow Department of Pathology, University of Nijmegen (Dr. A.H.N. Hopman, Prof. Dr. F.C.S. Ramaekers) Netherlands Science Foundation (NWO) project: Development of amplification systems to

enhance the detection sensitivity of nucleic acid sequences in situ. 1991-1995 PhD student Department of Molecular Cell Biology & Genetics, University of Maastricht (Dr. A.H.N. Hopman, Prof. Dr. F.C.S. Ramaekers) Development and application of non-isotopic DNA in situ hybridization (ISH) in combination

with immunocytochemistry (ICC), and evaluation of the primed in situ (PRINS) labeling and in situ polymerase chain reaction (PCR) methods as alternatives to ISH.

1995-1997 Postdoctoral research fellow Department of Molecular Cell Biology & Genetics, University of Maastricht (Dr. A.H.N. Hopman and Prof. Dr. F.C.S. Ramaekers) Projects: 1. Development, optimization and application of peroxidase-mediated deposition of haptenized

and fluorochromized tyramides to sensitive multiple-target ISH and ICC on tissue and cell preparations using fluorescence and brightfield microscopy.

2. High-resolution mapping of the genes coding for two human sarcomeric M band-specific proteins.

3. Localization of different RNA transcripts in tumor cells and muscle cells undergoing differentiation.

1997-2000 Scientific research fellow Department of Pathology, University of Zurich, Zurich, Switzerland (Dr. P. Komminoth and Prof. Dr. Ph.U. Heitz) Projects: 1. Detection of chromosomal aberrations in human (neuro)endocrine tumors (pancreas, adrenal

gland, lung, (para)thyroid) using (F)ISH on cell and tissue preparations, comparative genomic hybridization (CGH), molecular allelotyping, SSCP gene mutation analysis and laser-assisted microdissection.

2. Application of the tyramide signal amplification technology to sensitive mRNA and DNA (F)ISH on routinely fixed, paraffin-embedded tissue sections.

3. Analysis of oncogene amplifications in endocrine tumors and intimal sarcomas of the pulmonary artery using conventional and arrayCGH.

2000-2003: Assistant Professor (Lecturer), Staff member Department of Molecular Cell Biology, GROW-School for Oncology & Developmental Biology, University of Maastricht (Prof. Dr. F.C.S. Ramaekers) Projects: 1. Genomic and phenotypic analysis of head and neck tumors (and cell lines), its precursor lesions

and normal mucosa to study HPV infection and the development of chromosome instability, and their predictive value for malignant progression and tumor recurrence. Technologies used:

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mutation analysis, FISH, molecular allelotyping, (array)CGH, expression profiling, (RT)PCR, (laser-assisted) microdissection and immunohistochemistry.

2. Identification of tumor suppressor and oncogenes involved in the pathogenesis of (neuro)endocrine tumors (endocrine pancreatic tumors, pheochromocytomas, adrenal cortical tumors, carcinoids and cell lines) and meningiomas by means of mutation analysis, FISH, molecular allelotyping, (array)CGH, expression profiling, (RT)PCR and immunohistochemistry.

3. Genetic and phenotypic characterization of cancers of unknown primary tumor to examine their clonal evolution, specific biology and prognosis. Technologies used: CGH, FISH, molecular allelotyping, methylation-specific PCR analysis, microarray techniques, and immunohistochemistry.

2004-2007: Assistant Professor (Lecturer), Staff member (0.8 fte) Department of Molecular Cell Biology, GROW-School for Oncology & Developmental Biology, University of Maastricht (Prof. Dr. F.C.S. Ramaekers) Projects (see above, and below under Clinical Molecular Biologist) Clinical Molecular Biologist, Staff member (0.2 fte) Department of Pathology, Molecular Diagnostics Unit, Academic Hospital Maastricht/Maastricht University Medical Center (MUMC) (Prof. Dr. M.J.A.D. Daemen; Prof. Dr. A. zur Hausen) Projects: Identification of genomic and phenotypic alterations involved in the pathogenesis of different cancer types. Technologies (commercially available and home-brew) used: FISH, molecular allelotyping (fragment analysis),mutation-, methylation- and virus-specific PCR analysis, sequencing technologies (Sanger, pyrosequencing, NGS), (array)CGH, microarray techniques, and immunohistochemistry. Development, implementation, validation, application and reporting of molecular diagnostic tests for clinical diagnosis, e.g. detection of genetic alterations (gains, amplifications, losses), mutations, translocations, virus sequences and changes in gene expression to: 1. identify and classify tumors 2. detect clonality between different tumors 3. predict malignancy and/or tumor recurrence 4. predict metastatic progression 5. select the application and predict the efficacy of treatment Furthermore, experience has been acquired with quality assessment, and systems for data management, and laboratory management, as well as with regulations for working in a clinical laboratory (for example, ISO15189 / CCKL accreditation). 2007-2011: Associate Professor (Senior lecturer), Staff member (0.8 fte) Clinical Molecular Biologist, Staff member, (0.2 fte) Since March 1, 2011: Associate Professor (Senior lecturer), Staff member, Clinical

molecular biologist, Head Molecular Diagnostics (1.0 fte) at Maastricht University Medical Center (MUMC), Department of Pathology Since August 1, 2012: Professor in Molecular Oncopathology, Staff member, Clinical

molecular biologist, Head Laboratory Molecular Oncopathology & Diagnostics (1.0 fte)

at Maastricht University Medical Center (MUMC), Department of Pathology Since July 12, 2013: Registration as a Clinical Molecular Biologist in Pathology (KMBP) at the Netherlands Society for Pathology (NVVP) Projects (see above)

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Licenses, certifications, management courses 1982 Secondary School 1988 MSc (Drs.) degree in Biology 1995 PhD degree 2013 Clinical Molecular Biologist in Pathology (KMBP) 2015 GMO Teaching certifications at University of Maastricht 2000 Introduction Problem-based Teaching (PGO) Basic Tutortraining 2003 Presenting a lecture 2004 Use of animations and digital video in presentations 2014 Basic Clinical Teaching 2015 Basic Training in Workplace Assessment 2015 Examinator Training 2017 Advanced clinical teaching, quality of teaching (ACT) 2017 Basis Qualification Teaching (BKO) Research certifications at University of Maastricht 1991 English writing and presentation 1991 Medical statistics and regression analysis 1992 Molecular methods and technologies 1994 Molecular biology of cardiovascular diseases 2005 Survival analysis 2006 Writing and presenting research project applications 2011 Course Good Clinical Practice 2018 eBROK Research certifications at other universities 1986 Expert on radiation hygiene level 3 (at University of Nijmegen) 1991 Hybridocytochemistry (at University of Leiden) 1992 Molecular Genetics (at University of Leiden) 1997 Workshop Laser microdissection (at University of München, D) 1998 Workshop CGH (at University of Basel, CH) 1999 Workshop FISH (at University of Basel, CH) Courses Molecular Diagnostics 2008 Molecular Diagnostics (at 14th AMP Annual Meeting,

Grapevine, TX, USA) 2011 Introduction Roche GS Junior 454 sequencing Amplicon

Training (at Maastricht UMC, NL) Cobas 4800 Operator Training Roche 2012 ALK FISH test training (at University Hospital Antwerpen, B) Workshop: A practical guide to molecular testing in cancer (at

101st Annual USCAP Meeting, Vancouver, Ca) Training Day MET IHC scoring (at University Hospital Basel,

CH)

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2013 Euroclonality Workshop "Clonality assessment in Pathology" (at Radboud Univeristy Nijmegen Medical Center, NL)

Introduction Qiagen Pyromark 24 pyrosequencing analysis (at Maastricht UMC, NL)

2014 Introduction Illumina MiSeq NGS TruSight Tumor analysis (at Maastricht UMC, NL)

2015 Introduction Asuragen NGS PanCancer gene panel analysis (November 16-18, 2015, at Maastricht UMC, NL)

ISO15189 Awarenesstraining (at Maastricht UMC, NL) 2016 Training Day PD-L1 scoring (at Netherlands Cancer Institute

AvL,NKI, Amsterdam, NL) NGS course: Genomic resequencing in medical diagnostics

2016 (September 20-22, 2016, Rotterdam, The Netherlands) Training Day Idylla Biocartis system (at Maastricht UMC, NL) 2017 Training Biontech Mammatyper assay (August 29-31, at

Biontech, Mainz, Germany) Management/Leadership courses 2011 Conflict management (ALP) 2014 Avicenna Leadership course 2014 Yellow Belt Operational Excellence Scientific awards: 1994: FEBS short term fellowship: Utilization of PRINS, cycling PRINS and in situ PCR to enhance

the detection sensitivity of nucleic acid sequences in situ. Research visit: MRC Human Genetics Unit, Western General Hospital, Edinburgh, United

Kingdom (Dr. J.R. Gosden; May and December 1994)). 1994: Van Walree Foundation (KNAW): Research visit: MRC Human Genetics Unit, Western General Hospital, Edinburgh, United

Kingdom (Dr. J.R. Gosden; May and December 1994)). 1996: Young Histochemist Award, International Federation of Societies for Histochemistry and

Cytochemistry (received in Kyoto, Japan, August 1996). 1999: Robert Feulgen Prize, Society for Histochemistry (received in Gargellen, Austria, September

1999). 2005: Best oral communication (as presenting and senior author), 20

th European Congress of

Pathology (received in Paris, France, September 6) 2011: Third Prize, Best oral presentation session, 23

rd European Congress of Pathology, Helsinki,

Finland (September 1). Scientific awards of trainees/PhD students: 2006: Drs. Y. Jonkers: Best abstract, 3

rd Annual European NeuroEndocrine Tumor Society

Conference (received in Prague, Chech Republic, March 24). 2010: Drs. D. Swarts: Best poster abstract, 7

th European NeuroEndocrine Tumor Society

Conference (received in Berlin, Germany, March 12). Drs. R. Hamers: Young investigator award (oral presentation), 4th World Congress of the

International Federation of Head and Neck Oncological Societies (received in Seoul, Korea, June 15).

2012: Drs. D. Swarts: Best basic science abstract (oral presentation), 9th European NeuroEndocrine Society Conference (received in Copenhagen, Denmark, March 8)

2015 Dr. D. Swarts: Vera Bonte Prize 2015 for best thesis on lung cancer research in the Netherlands and Belgium (received in Amsterdam, Netherlands, January 16).

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Drs. J. Derks: Best poster abstract, 12th European NeuroEndocrine Tumor Society

Conference (received in Barcelona, Spain, March 13). Drs. J. Derks: Best PhD student abstract, Post-WCLC meeting on lung cancer (received in

Roosteren, Netherlands, October 12). Drs. J. Derks: Two invited abstracts for oral presentation, 8th Annual meeting of the

NANETS, October 14-18, 2015, Austin, Tx, USA 2016 Drs. J. Derks: European Respiratory Society (ERS) Short-term Fellowship to visit the

AICR/WHO institute in Lyon, France (Dr. L. Fernandez-Cuesta), September-December 2016.

2017 Drs. J. Derks: Travel grant to visit and present a poster at the 14th Annual ENETS conference, March 8-10, 2017, Barcelona, Spain,

5. Main clinical interest (in chronological order) 1) Molecular diagnostics for cancer diagnosis, prognosis and therapy selection

2) Molecular Pathology 3) Pharmacogenomics 4) Oncology (Head and Neck Cancer, Endocrine-related Cancer, Virus-related Cancer, Lung cancer, Skin cancer)

6. Teaching experience

Regular courses per faculty, University of Maastricht and MUMC Faculty of Health, Medicine and Life Sciences (FHML) (since 2000): Coordinator: 1) Course 2.6: Predictive Medicine 2) Course Master Biomedical Sciences 1102: Clinical and applied genetics and genomics Planning group member: 1) Course 2.6: Predictive Medicine 2) Course 2.6: Hypoxia and Cancer 3) Course Master Biomedical Sciences 1102: Clinical and applied genetics and genomics Tutor, Supervisor (practical), Observant, Lecturer: 1) Course 1.7: Cell communication (Tutor, Supervisor practical) 2) Course 1.4: Immune system (Tutor) 3) Course 2.1: The cell (Tutor, Supervisor practical) 4) Course 2.2: Growth & Development II (Tutor) 5) Course 2.3: The science behind the diagnosis (Pathology) (Tutor, Lecturer) 6) Course 2.5: Growth & Development (Tutor) 7) Course 2.6: Predictive Medicine (Tutor, Supervisor practical) 8) Course 2.6: Hypoxia and Cancer (Supervisor practical) 9) Course 3.3: The diseased organism (Lecturer) 10) Course 3.7: Practical genetics and cell biology (Tutor, Supervisor practical) 11) Course BMW 1005: Genes rule (Tutor) 12) Honours program Scientific Research GROW, year 2 (Lecturer) 13) Skills Training Examination (Observant) 14) Medical Training Otorhinolaryngology, year 4 (Lecturer) 15) 18-week Scientific Participation, year 6 (Supervisor) 16) 18-week AKO Master phase IV practical period, year 2 (Supervisor)

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17) AKO Master, year 1: Course Thorax (Lecturer, examinator) 18) Master BioMedical Sciences: Supervisor practical period abroad 19) Medicine Master Neurosciences, year 1 (half a day per month for 15 students): Teaching in molecular pathology of head and neck cancer (Lecturer, supervisor) University College Maastricht, Bachelor Program, 8-week courses (2002-2012): Coordinator: 1) Period 1, year 1: Introduction to Biology 2) Period 1 and 4, year 1: Introduction to Biology for King Abdullah Scholarship (KAS)

students from Saudi Arabia 3) Period 4, year 2: Lab skills Cell Biology & Genetics 3) Period 5, year 2: Molecular Genetics, Cell Biology & Disease 4) Period 6, year 2: Molecular Genetics Planning group member: 1) Period 1, year 1: Introduction to Biology 2) Period 1 and 4, year 1: Introduction to Biology for KAS students from Saudi Arabia 3) Period 3 and 6, year 1: Science & Health for regular students and KAS students from

Saudi Arabia 4) Period 4, year 2: Lab skills Cell Biology & Genetics 5) Period 4, year 3: Cellular dynamics and communication 6 Period 5, year 2: Molecular Genetics, Cell Biology & Disease 7 Period 6, year 2: Molecular Genetics Tutor, Supervisor practical & workshop, lecturer: 1) Period 1, year 1: Introduction to Biology (Tutor, Supervisor workshop, Lecturer) 2) Period 1 and 4, year 1: Introduction to Biology for KAS students from Saudi Arabia

(Lecturer and tutor) 3) Period 3 and 6, year 1: Science & Health for regular students and KAS students from

Saudi Arabia (Lecturer) 4) Period 4, year 2: Lab skills Cell Biology & Genetics (Supervisor practical, Tutor) 5) Period 5, year 2: Molecular Genetics, Cell Biology & Disease (Tutor, Supervisor

Practical & Workshop, Lecturer) 6) Period 6, year 2: Molecular Genetics (Tutor, Supervisor Practical, Lecturer) Transnational University Limburg/Molecular Life Sciences (Since 2004): Supervisor, Tutor, Lecturer: 1) Minor practical period (8 weeks), year 3: HPV-related carcinogenesis; Chromosomal

instability (Tutor, Supervisor, Lecturer) 3) Course 1.3: Frome gene to individual (Supervisor practicals DNA isolation and

analysis) 2) Course 3.1: The sick cell (Supervisor practicals FISH and microarray analysis) 3) Course 3.2: Sick organs (Tutor) 4) GROW Oncology and Developmental Biology Master, year 1, course 1.2:

Chromosomal instability (Lecturer, Supervisor presentations)

Post-doctoral courses, MUMC 1) Lecturer at PhD student course Research Institute CARIM: Molecular biology of

cardiovascular diseases 2) Tutor at PhD student course GROW-School for Oncology & Developmental Biology:

Molecular methods and technologies

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Miscelaneous teaching activities 1) Supervision of several lab technicians as well as lab technicians (from Laboratory High

Schools in amongst others Heerlen, Nijmegen, Utrecht, Leuven, Hasselt) and biology, molecular life sciences, and medical students (from Universities in amongst others Maastricht, Nijmegen, Wageningen, Amsterdam, Utrecht, Hasselt, Ghent, Cologne, Heidelberg and Zurich) during their practical research periods at the Department of Molecular Cell Biology, University of Maastricht and MUMC, Maastricht, The Netherlands (1992-1997 and since 2000), and the Departments of Pathology, University of Zurich, Zurich, Switzerland (1997-1999) and MUMC, Maastricht, The Netherlands (since 2004).

2) Supervision of PhD students from foreign universities (Uppsala, Cologne, Liestal,

Heidelberg) at the Department of Molecular Cell Biology, MUMC, The Netherlands for technology transfer (since 2001).

3) Lecturer and student supervisor, third year course “Biochemistry” at the Hoge School Zuyd

for Laboratory Technicians, Heerlen, The Netherlands (since 2004). 4) Lecturer, post-academic courses "In situ hybridization", "Multiple staining in

immunohistochemistry", "Advances in PCR techniques" and “RNA: from research to diagnostics”, held at the Training Center Medical Biotechnology (TMB), Avans High School, Breda, The Netherlands (since 1994).

5) Organization and presentation of the post-academic course "In situ hybridization", held at

the Training Centre Medical Biotechnology (TMB), Hogeschool West-Brabant, Polytechnic Faculty, Etten-Leur, The Netherlands (1997-2003).

6) Organization, lecturer and student supervisor, yearly post-academic course “Molecular Diagnostics”, Maastricht University Medical Center, The Netherlands (2009-2013).

7) Lecturer at special resident Pathology teaching meetings, and supervisor for residents Pathology during their practical research and molecular pathology and diagnostics periods (since 2011).

8) Organization and presentation of course day “How do we study genetic and epigenetic

alterations”, Course “Molecular Biology for Pathologists”, European School for Pathology Molecular Pathology Courses (European Society of Pathology), March 23-29, 2012, Pisa, Italy.

9) Organization Course "Molecular Biology for Pathologists", European School for Pathology Molecular Pathology Courses (European Society of Pathology), March 31-April 4, 2014, Graz, Austria.

10) Organization as a member of the Pathology teaching staff of a Molecular Diagnostics teaching program (1 hour per two weeks) for residents Pathology. Furthermore, three times per year a half day teaching program is organized for residents on molecular oncopathology and circulation testing (since 2015).

11) Organization (with colleagues in NL and Benecke) of a post-academic online course "Molecular diagnostics of lung cancer" for residents and pulmonologists (2015-2016)

7. Management positions

Departmental: 1) Supervisor research group head and neck cancer 2) Supervisor research group neuro-endocrine tumors

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3) Supervisor research group lung tumors 4) Supervisor research group virus-related cancer 5) Supervisor research group neuro-oncology 6) Supervisor of medical, AKO, and tUL/BMW/MLW students, technicians, PhD students

and clinical fellows (University of Zurich (1997-2000); MUMC (since 2000)) 6) Staff member, Department of Molecular Cell Biology, MUMC (2000-2011) 7) Staff member, Department of Pathology, MUMC (since 2004) 8) Head Molecular Diagnostics, Laboratory Molecular Oncopathology & Diagnostics,

Department of Pathology, MUMC (since 2011) 9) Chairman Science and Laboratory Committee, Department of Pathology, MUMC

(since 2013) 10) Member Management Board, Department of Pathology, MUMC (since 2014) 11) Reponsible research supervisor Genetically Modified Organisms, Department of

Pathology, MUMC (since 2016) Institutional: 1) Member committee UCM for planning curriculum life sciences (2003-2011) 2) Member committee UCM for planning curriculum pre-medicine year for KAS students from Saudi Arabia (2009-2011) 3) Member Molecular Diagnostics Advisory Board, MUMC (since 2011) 4) Member Multidiciplinary Team Melanoma Centre MUMC, Lung Cancer, Head and Neck Cancer, Neuro-oncology (since 2011) 5) Deputy member Pathology in Oncology Committee, MUMC (since 2013) 6) Clinical Molecular Biologist in Pathology (KMBP) (since 2013) 7) PI member GROW-School for Oncology & Developmental Biology, division Oncology, program Basic and Translational Cancer Biology (since 2014) Regional: 1) Member Lung cancer, melanoma, head and neck cancer and neurooncology team, Oncology South East Netherlands (OncoZON) (since 2014) National: 1) Member Committee Molecular Diagnostics in Pathology (CMDP) of the Netherlands Society for Pathology (NVVP) (since 2012) 2) Member of the HPV committee of the CMDP (since 2012) 3) Member QC committee of the CMDP (since 2013), Chairman since 2015 4) Member of the Netherlands Foundation Quality Medical Laboratories (SKML), section Pathology (since 2015) 5) Member of the HPV committee of the Netherlands Working Group on Head and Neck Tumors (NWHHT) (since 2015) 6) Member of the Committee Quality and Professional Performance (CKBU) of the NVVP (since 2017)

8. Major received competitive funding from national and international organizations

(per project) Name project: Genomic alterations associated with prognosis in endocrine pancreatic

tumors

Period: 1998-1999

Project coordinator: P. Komminoth

Co-applicant: E. Speel

Other participants: J. Roth, Ph. Heitz

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Applicant address: Department of Pathology, University of Zurich Schmelzbergstrasse 12, Zurich, Switzerland Funded by: Swiss Cancer Foundation Sum of contract in Euro’s: CHF 104,000 Sum to person C.V: CHF 52,000 Results: Speel EJM, Saremaslani P, Roth J, Heitz PU, Hopman AHN, Komminoth P: Improved mRNA in situ hybridization on

formaldehyde-fixed, paraffin-embedded tissue using signal amplification with different haptenized tyramides. Histochem. Cell Biol. 110, 571-577, 1998.

Perren A, Roth J, Muletta-Feurer S, Saremaslani P, Speel EJM, Heitz PU, Komminoth P. Clonal analysis of sporadic pancreatic endocrine tumours. J. Pathol. 186, 363-371, 1998.

Görtz B, Roth J, Krähenmann, De Krijger RR, Muletta-Feurer S, Rütimann, Saremaslani P, Speel EJM, Heitz PU, Komminoth P: Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine (carcinoid) tumors and not restricted to foregut neoplasms. Am. J. Pathol. 154, 429-436, 1999.

Speel EJM, Richter J, Moch H, Egenter C, Zhao J, Saremaslani P, Rütimann K, Barghorn A, Roth J, Heitz PU, Komminoth P: Genetic differences between sporadic endocrine pancreatic tumor subtypes detected by comparative genomic hybridization. Am. J. Pathol. 155, 1787-1794, 1999.

Zhao J, De Krijger RR, Meier D, Speel EJM, Saremaslani P, Muletta-Feurer S, Matter C, Roth J, Heitz PU, Komminoth P: Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (Carcinoids). Marked differences indicating diversity in molecular pathogenesis. Am J. Pathol. 157, 1431-1438, 2000.

Barghorn A, Speel EJM, Farspour B, Saremaslani P, Schmid S, Perren A, Roth J, Heitz PU, Komminoth P: Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors. Am. J. Pathol. 158, 1903-1911, 2001.

Speel EJM, Scheidweiler AF, Zhao J, Matter C, Saremaslani P, Roth J, Heiz PU, Komminoth P: Genetic evidence for early divergence of small functioning and non-functioning endocrine pancreatic tumors: Gain of 9q34 is an early event in insulinomas. Cancer Res. 61, 5186-5192, 2001.

Barghorn A, Komminoth P, Bachmann D, Rütimann K, Saremaslani P, Muletta-Feurer S, Roth J, Heitz PU, Speel EJM: Chromosome 3p alterations in endocrine pancreatic tumors: a common region of allelic loss at 3p23-p25 and association of 3p loss with advanced disease. J. Pathol. 194, 450-457, 2001.

Zhao J, Moch H, Scheidweiler AF, Baer A, Schäffer AA, Speel EJM, Roth J, Heitz PU, Komminoth P: Genomic imbalances in the progression of endocrine pancreatic tumors. Genes Chromosomes Cancer 32, 364-372, 2001.

Name project: Genomic alterations associated with prognosis in endocrine

pancreatic tumors.

Period: 1998-1999

Project coordinator: E. Speel Co-applicant: P.Komminoth Other participants: J. Roth, Ph. Heitz Applicant address: Department of Pathology, University of Zurich Schmelzbergstrasse 12, Zurich, Switzerland Funded by: Swiss National Science Foundation Sum of contract: CHF 165,000 Sum to person C.V: CHF 82,500 Results: See above

Name project: Prognostic significance of genomic alterations in adenoid cystic carcinoma of the salivary glands

Period: 1999-2000

Project coordinator: M. Pfaltz Co-applicant: E. Speel Other participants: S. Schmid, P.Komminoth, Ph. Heitz Applicant address: Department of Pathology, University of Zurich Schmelzbergstrasse 12, Zurich, Switzerland Funded by: Medical Research Foundation University of Zurich Sum of contract: CHF 50,000

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Sum to person C.V: CHF 25,000 Results: Stallmach I et al. Loss of heterozygosity at chromosome 6q23-25 correlates with clinical and histologic parameters in

salivary gland adenoid cystic carcinoma. Virchows Archiv 440, 77-84, 2002

Name project: Prognostic significance of genetic aberrations in significant and insignificant prostate adenocarcinomas

Period: 1997-1999

Project coordinator: S. Hailemariam Co-applicant: E. Speel Other participants: P.Komminoth, Ph. Heitz Applicant address: Department of Pathology, University of Zurich Schmelzbergstrasse 12, Zurich, Switzerland Funded by: Medical Research Foundation University of Zurich Sum of contract: CHF 99,000 Sum to person C.V: CHF 49,500 Results: Häussler O et al. Cell proliferation, apoptosis, oncogene, and tumor suppressor gene status in adenosis with comparison

to benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and cancer. Hum Pathol 30, 1077-1086, 1999

Name project: Euregional collaboration molecular diagnosis of unknown primary adenocarcinomas

Period: 2000-2002

Project coordinator: E. Speel

Other participants: F. Ramaekers, H. Hillen, R. Osieka, P. Delvenne Applicant address: Department of Molecular Cell Biology, UM P.O. Box 616, 6200 MD Maastricht, NL Funded by: CONCERT (the Cancer Foundation Euregion Meuse-Rhine) Sum of contract in Euro’s: DFL 100,000 Sum to person C.V: DFL 100,000 Results: Speel EJM et al. Genetic characterization of different distant metastases in patients with cancers of unknown primary site.

Proc AACR 42, 194, 2001. Van de Wouw Y, Jansen RLH, Speel EJM, Hillen HFP: The unknown biology of the unknown primary tumor: a literature

review. Annal. Oncol. 14, 191-196, 2003. Van de Wouw AJ et al. Clinical and immunohistochemical analysis of patients with unknown primary tumor. A search for

prognostic factors in UPT. Anticancer Res 24, 297-301, 2004.

Name project: Early diagnosis of progressive premalignant head and neck lesions based on the detection of chromosomal markers

Period: 2001-2004


Other participants: J.J. Manni, F. Ramaekers Applicant address: Department of Molecular Cell Biology, UM P.O. Box 616, 6200 MD Maastricht, NL Funded by: Medical Research Foundation azM (Profileringsfonds) Sum of contract in Euro’s: DFL 200,000 Sum to person C.V: DFL 200,000 Results: Veltman JA et al. Specific steps in aneuploidization correlate with loss of heterozygosity of 9p21, 17p13 and 18q21 in the

progression of pre-malignant laryngeal lesions. Int J Cancer, 91, 193-199, 2001. Van der Toorn PP et al. Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability

to detect residual (pre)malignant cells. J Pathol 193, 66-72, 2001.

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Bergshoeff VE, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers FCS, Manni JJ, Speel EJM: Chromosome

instability as detected by FISH predicts progression of premalignant lesions of the larynx. 21st European Congress of

Pathology, September 8-13, 2007, Istanbul, Turkey. Virchows Archiv, 451, 188-189, 2007 (abstract OP29-3). Bergshoeff VE, Hopman AHN, Zwijnenberg IR, Ramaekers FCS, Bot FJ, Kremer B, Manni JJ, Speel EJM. Letter to the

editor. Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma. J Pathol 215, 347-348, 2008.

Siebers TJ, Bergshoeff VE, Otte-Höller I, Kremer B, Speel EJM, Van der Laak JA, Merkx MAW, Slootweg PJ: Chromosome instability predicts the progression of premalignant oral lesions. Oral Oncol 49, 1121-1128, 2013.

Bergshoeff VE, Van der Heijden SJ, Haesevoets A, Litjens SGH, Bot FJ, Voogd AC, Chenault MN, Hopman AHN, Schuuring EMD, Van der Wal JE, Manni JJ, Ramaekers FCS, Kremer B, Speel EJM: Chromosome instability predicts progression of premalignant lesions of the larynx. Pathology 2014, in press (Epub Mar 8)

Name project: Molecular characterization of unknown primary tumors

Period: 2003-2005


Other participants: F. Ramaekers, H. Hillen Applicant address: Department of Molecular Cell Biology, UM P.O. Box 616, 6200 MD Maastricht, NL Funded by: CONCERT (the Cancer Foundation Euregion Meuse-Rhine) Sum of contract in Euro’s: € 40,000 Sum to person C.V: € 40,000 Results: Van de Wouw Y, Jansen RLH, Speel EJM, Hillen HFP: The unknown biology of the unknown primary tumor: a literature

review. Annal. Oncol. 14, 191-196, 2003. Van de Wouw AJ et al. Clinical and immunohistochemical analysis of patients with unknown primary tumor. A seqrch for

prognostic factors in UPT. Anticancer Res 24, 297-301, 2004. Van de Wouw AJ. Unknown Primary Tumor. Thesis, 2005. Speel EJM, Van de Wouw AJ, Claessen SMH, Haesevoets A, Hopman AHN, Van der Wurff AAM, Osieka R, Buettner R,

Hillen HFP, Ramaekers FCS. Molecular evidence for a clonal relationship between multiple lesions in unknown primary tumor patients. Int J Cancer 123, 1292-1300, 2008.

Name project: Identification of genes on chromosomes 9q34 and 6q22-24 associated with the development and progression of endocrine pancreatic tumors

Period: 2003-2007


Other participants: Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Netherlands Foundation Vanderes Sum of contract in Euro’s: € 118,046 Sum to person C.V: € 118,046 Results: Jonkers YMH, Claessen SMH, Perren A, Schmid S, Komminoth P, Verhofstad AA, Hofland LJ, De Krijger RR, Slootweg

PJ, Ramaekers FCS, Speel EJM: Chromosomal instability predicts metastatic disease in patients with insulinomas. Endocrine-related Cancer 12, 435-447, 2005.

Jonkers YMH, Claessen SMH, Veltman JA, Geurts van Kessel A, Dinjens WNM, Skogseid B, Ramaekers FCS, Speel EJM. Molecular parameters associated with insulinoma progression: chromosomal instability versus p53 and CK19 status. Cytogenet Genome Res 115, 289-297, 2006.

Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman JA, Speel EJM. Novel candidate

tumor suppressor gene loci on chromosomes 11q23-24 and 22q13 involved in human insulinoma tumorigenesis. J Pathol 210, 450-458, 2006 .

Jonkers YMH, Ramaekers FCS, Speel EJM. Molecular alterations during insulinoma tumorigenesis. BBA Reviews in Cancer 1775, 313-332, 2007.

Jonkers YMH, Ramaekers FCS, Speel EJM: Moleculaire veranderingen tijdens de progressie van insulinomen. Kanker 31, June 2007, pp. 30-34.

Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder W, De Krijger RR, Verhofstad AA, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM. DNA copy number status is a powerful predictor of survival in endocrine pancreatic tumor patients. Endocrine-related Cancer 14, 769-779, 2007.

Jonkers YMH. Molecular alterations during insulinoma tumorigenesis. Thesis, 2007.

13

Name project: Identification of genes involved in the pathogenesis of human insulinomas

Period: 2004-2007


Other participants: Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Netherlands Foundation Sacha Swarttouw-Hijmans Sum of contract in Euro’s: € 20,000 Sum to person C.V: € 20,000 Results: See above

Name project: Identification of genes involved in endocrine pancreatic tumor development and progression

Period: 2004-2007


Other participants: P. Komminoth, B. Skogseid Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Association for International Cancer Research, St. Andrews, U.K. Sum of contract in Euro’s: £ 119,853 Sum to person C.V: £ 119,853 Results: See above

Name project: Impact of virus integration and chromosomal instability on the development and progression of human papillomavirus-related tumors

Period: 2005-2009


Other participants: T. Hopman Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Transnational University Limburg/Molecular Life Sciences Sum of contract in Euro’s: € 200,000 Sum to person C.V: € 200,000 Results: Hopman AHN, Theelen W, Hommelberg P, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Smedts F, Ramaekers

FCS. Genomic integration of oncogenic HPV and gain of the Human Telomerase Gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. J Pathol 210, 412-419, 2006

Theelen W, Reijans M, Simons G, Ramaekers FCS, Speel EJM, Hopman AHN. A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer 126, 959-975, 2010 (Epub Aug25, 2009).

Theelen W, Speel EJM, Herfs M, Reijans M, Simons G, Ramaekers FCS, Somja J, Delvenne P, Hopman AHN. Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. Am J Pathol 77, 2022-2033, 2010.

Theelen W. Molecular progression markers in cervical premalignancies. Development of a diagnostic MLPA-assay. Thesis, 2011.

14

Name project: Reliability of p16INK4A

overexpression as a biomarker for human papillomavirus infection in oropharyngeal lesions and cancers of unknown primary

Period: 2006-2009


Other participants: Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Kootstra Fellowship UM Sum of contract in Euro’s: € 21,056 Sum to person C.V: € 21,056 Results:

Speel EJM, Klingenberg B, Hafkamp HC, Haesevoets A, Slootweg PJ, Weissenborn SJ, Klussmann JP, Manni JJ: Is p16

INK4A overexpression a reliable biomarker for oncogenic human papillomavirus infection in normal tonsils? 76.

Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, May 4-8, 2005, Erfurt, Germany. HNO-Informationen 30, 88-89, 2005.

Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK, Speel EJM, Dienes HP, Pfister HJ,

Guntinas-Lichius O, Klussmann JP. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 120, 1731-1738, 2007.

Smeets SJ, Hesselink AT, Speel EJM, Haesevoets A, De Vries J, Snijders PJF, Pawlita M, Meijer CJLM, Braakhuis BJ, Leemans CR, Brakenhoff RH: A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 121, 2465-2472, 2007 (Epub Aug 6, 2007).

Hafkamp HC, Mooren JJ, Claessen SHM, Klingenberg B, Voogd AC, Bot FJ, Klussmann JP, Hopman AHN, Manni JJ,

Kremer B, Ramaekers FCS, Speel EJM. P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Modern Pathol 22, 686-698, 2009 (Epub Mar 20, 2009).

Klingenberg B, Hafkamp HC, Haesevoets A, Manni JJ, Slootweg PJ, Weissenborn SJ, Klussmann JP, Speel EJM.

p16INK4A

overexpression is frequently detected in tumor-free tonsil tissue without association with HPV. Histopathology 56, 957-967, 2010.

Name project: Identification of genomic profiles in HPV-positive and –negative oropharyngeal tumors

Period: 2006-2009


Other participants: J.J. Manni Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Foundation Scientific Research Otorhinolarayngology Maastricht Sum of contract in Euro’s: € 70,000 Sum to person C.V: € 70,000 Results:

Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK, Speel EJM, Dienes HP, Pfister HJ,

Guntinas-Lichius O, Klussmann JP. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 120, 1731-1738, 2007.

Hafkamp HC, Manni JJ, Haesevoets A, Voogd AC, Schepers M, Bot FJ, Hopman AHN, Ramaekers FCS, Speel EJM. Marked differences in survival rate between smokers and non-smokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 122, 2656-2664, 2008 (Epub March 21, 2008).

Preuss SF, Weinell A, Molitor M, Stenner M, Semrau R, Drebber U, Weissenborn SJ, Speel EJM, Wittekindt C, Guntinas-Lichius O, Hoffmann TK, Eslick GD, Klussmann JP.

Nuclear survivin expression is associated with HPV-independent

carcinogenesis and is a negative prognostic marker in oropharyngeal squamous cell carcinoma. Br J Cancer 98, 627-632, 2008 (Epub Jan 22, 2008).

Klussmann JP, Mooren JJ, Lehnen M, Claessen SM, Stenner M, Huebbers CU, Weissenborn SJ, Wedemeyer I, Preuss SF, Straetmans JM, Manni JJ, Hopman AH, Speel EJM. Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res 15, 1779-1786, 2009 (Epub Feb 17, 2009).

Hafkamp HC, Mooren JJ, Claessen SHM, Klingenberg B, Voogd AC, Bot FJ, Klussmann JP, Hopman AHN, Manni JJ,

Kremer B, Ramaekers FCS, Speel EJM. P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Modern Pathol 22, 686-698, 2009 (Epub Mar 20, 2009).

15

Name project: Identification of new tumor suppressor genes on chromosome 11q in lung carcinoids

Period: 2007-2009


Other participants: Y.M.H. Jonkers Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Netherlands Foundation “De Drie Lichten” Sum of contract in Euro’s: € 6,000 Sum to person C.V: € 6,000 Results: Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, Seldenrijk KA, De Krijger RR, Slootweg PJ,

Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. 100

th Annual Meeting of the AACR, April 18-22, 2009, Denver, USA. Proceedings AACR

50, 341, 2009 (abstract 1424). Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans A-MC, De Herder WW, De Krijger RR, Smit EF,

Thunnissen FBJM, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS, Speel EJM. Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and a poor clinical outcome. Am J Pathol 179, 1129-1137, 2011.

Name project: Identification of new, epigenetically inactivated tumor suppressor genes in carcinoid tumors

Period: 2008-2011


Other participants: Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Netherlands Foundation Vanderes Sum of contract in Euro’s: € 62,792 Sum to person C.V: € 62,792 Results: Running Swarts DRA, ScarpaA, Corbo V, Van Criekinge W,

Van Engeland M,

Gatti G, Henfling ME, Papotti M, Perren A,

Ramaekers FCS, Speel EJM, Volante M: MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids. J Clin Endocrinol Metab 99, E374-378, 2014 (Epub 2013 Nov 25).

Rapa I, Votta A, Felice B, Righi L, Giorcelli J, Scarpa A, Speel EJM, Scagliotti GV, Papotti M, Volante M: Identification of microRNAs differentially expressed in lung carcinoid subtypes and progression. Submitted for publication

Name project: Development of a model system to test the therapeutic efficacy of antiviral agents in combination with radiotherapy for the treatment of HPV related cancer

Period: 2008-2011


Co-applicant: T. Hopman

Other participants: Ph. Lambin, B. Kremer Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: GROW, MUMC Sum of contract in Euro’s: € 10,000 Sum to person C.V: € 5,000 Results:

16

Olthof NC, Kremer B, Henfling M, Ramaekers FCS, Speel EJM: Characterization of HPV-positive head and neck squamous cell carcinoma cell lines. 214

th General Meeting of the Netherlands Society of Otorhinolaryngology and Head

and Neck Surgery, April 23-24, 2009, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 15, 87, 2009.

Olthof NC, Straetmans JMJAA, Snoeck R, Ramaekers FCS, Kremer B, Speel EJM: Next generation treatment strategies for HPV-related head and neck squamous cell carcinomas: where do we go? Rev Med Virol 22, 88-105, 2012.

Name project: Therapeutic potential of novel antiviral strategies in combination with radiotherapy for the treatment of human papillomavirus-related oropharyngeal cancer

Period: 2008-2012


Co-applicant: B. Kremer

Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: MUMC Sum of contract in Euro’s: € 200,000 Sum to person C.V: € 200,000 Results: Running Straetmans JMJAA, Olthof N, Mooren JJ, De Jong J, Speel EJM, Kremer B: Human papillomavirus reduces nodal

involvement as prognostic indicator in tonsillar squamous cell carcinomas. Laryngoscope 119, 1951-1957, 2009. Olthof NC, Kremer B, Henfling M, Ramaekers FCS, Speel EJM: Characterization of HPV-positive head and neck

squamous cell carcinoma cell lines. 214th General Meeting of the Netherlands Society of Otorhinolaryngology and Head

and Neck Surgery, April 23-24, 2009, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 15, 87, 2009.

Olthof NC, Straetmans JMJAA, Snoeck R, Ramaekers FCS, Kremer B, Speel EJM: Next generation treatment strategies for HPV-related head and neck squamous cell carcinomas: where do we go? Rev Med Virol 22, 88-105, 2012.

Sørensen BS, Busk M, Olthof NC, Speel EJM, Horsman MR, Alsner J, Overgaard J: Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells. Radiother Oncol 108, 500-505, 2013.

Name project: Identification of insulinoma-promoting genes on chromosome 9q

Period: 2007-2012


Other participants: Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Dutch Digestion Foundation (MLDS) Sum of contract in Euro’s: € 123,400 Sum to person C.V: € 123,400 Results: Running Lopez JR, Claessen SMH, Macville MVE, Albrechts JCM, Skogseid B, Speel EJM.

Spectral karyotypic and comparative

genomic analysis of the human endocrine pancreatic tumor cell line BON-1. Neuroendocrinology 91, 131-141, 2010 (Epub Oct 29, 2010).

Henfling M, Jonkers YMH, Claessen SMH, Ramaekers FCS, Starke A, Schmitt A, Perren A, Sprij D, Hofland LF, Speel EJM: Expression of EGFR and IGF pathway genes in insulinomas. Neuroendocrinology 94 (suppl 1), 5, 2011 (abstract B13).

Marinoni I, Kurrer AS, Vassella E, Dettmer M, Rudolph T, Banz V, Hunger F, Pasquinelli S, Speel EJM, Perren A: Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors. Gastroenterology 146, 453-460, 2014 (Epub 2013 Oct 19).

Name project: Chromosomal instability detected by FISH for recognition of head

and neck precursor lesions at risk for progression

17

Period: 2008-2011


Other participants: J.J. Manni Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Dutch Cancer Foundation (KWF) Sum of contract in Euro’s: € 161,400 Sum to person C.V: € 161,400 Results: Bergshoeff VE, Hopman AHN, Zwijnenberg IR, Ramaekers FCS, Bot FJ, Kremer B, Manni JJ, Speel EJM. Letter to the

editor. Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma. J Pathol 215, 347-348, 2008.

Bergshoeff VE, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM: Chromosome instability predicts progression of

premalignant lesions of the larynx. 2nd

World Congress of the International Academy of Oral Oncology, July 8-11, 2009, Toronto, Canada. Oral Oncology Suppl 3, 90-91, 2009 (abstract O103).

Speel EJM, Slootweg PJ, Van der Laak JA, Otte-Höller I, Bergshoeff VE, Haesevoets A, Takes RP, Fleskens AJ: Aneuploidy detection by DNA image cytometry and FISH recognizes pregressive premalignant head and neck lesions. 22

nd European Congress of Pathology, September 4-9, 2009, Florence, Italy. Virchows Archiv 455, Suppl 1, S27, 2009

(abstract OP7.11). Fleskens S, Takes R, Otte-Höller I, Van Doesburg L, Smeets A, Speel EJM, Slootweg PJ, Van der Laak J. Simultaneous

assessment of DNA ploidy and biomarker expression in paraffin-embedded tissue sections. Histopathology 57, 14-26, 2010.

Fleskens AJHM, Bergshoeff VE, Voogd AC, Van Velthuysen MLF, Bot FJ, Speel EJM, Kremer B, Takes RP, Slootweg PJ.

Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation. Modern Pathol 24, 892-898, 2011.


Sturm B, Fleskens SJ, Bot FJ, van Velthuysen ML, Speel EJM, Slootweg PJ, van der Laak JAWM: Virtual microscopy is a valid alternative for the diagnostic assessment of laryngeal premalignancies. Histopathology 64, 602-604, 2014 (Epub 2013 Nov 6).

Bergshoeff VE, Van der Heijden SJ, Haesevoets A, Litjens SGH, Bot FJ, Voogd AC, Chenault MN, Hopman AHN, Schuuring EMD, Van der Wal JE, Manni JJ, Ramaekers FCS, Kremer B, Speel EJM: Chromosome instability predicts progression of premalignant lesions of the larynx. Pathology 2014, in press (Epub Mar 8).

Name project: Development of a MLPA test to predict malignancy and prognosis in

endocrine pancreatic tumors

Period: 2008-present


Other participants: Y.M.H. Jonkers Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Kootstra Fellowship UM Sum of contract in Euro’s: € 50,232 Sum to person C.V: € 50,232 Results: Running Name project: Unmasking epigenetically silenced tumor suppressor genes in

pulmonary carcinoids



Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: GROW-School for Oncology & Developmental Biology Sum of contract in Euro’s: € 160,000 Sum to person C.V: € 160,000

18

Results: Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, Seldenrijk KA, De Krijger RR, Slootweg PJ,

Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. 100

th Annual Meeting of the AACR, April 18-22, 2009, Denver, USA. Proceedings AACR

50, 341, 2009 (abstract 1424). Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans A-MC, De Herder WW, De Krijger RR, Smit EF,

Thunnissen FBJM, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS, Speel EJM. Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and a poor clinical outcome. Am J Pathol 179, 1129-1137, 2011.

Swarts DRA, Ramaekers FCS, Speel EJM: Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. BBA Reviews in Cancer 1826, 255-271, 2012.

Swarts DRA, Henfling ME, Van Neste L, Van Suylen RJ, Dingemans AM, Dinjens WNM, Haesevoets A, Rudelius M, Thunnissen E, Volante M, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: CD44 and OTP are strong prognostic markers for pulmonary carcinoids. Clin Cancer Res 19, 2197-2207, 2013.

Swarts DRA, Van Neste L, Henfling ME, Eijkenboom I, Eijk PP, Van Velthuysen ML, Vink A, Volante M, Ylstra B, Van

Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: An exploration of pathways involved in lung carcinoid progression using gene expression profiling. Carcinogenesis 34, 2726-2737, 2013.

Swarts DRA, ScarpaA, Corbo V, Van Criekinge W, Van Engeland M,


Ramaekers FCS, Speel EJM#, Volante M: MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids. J Clin Endocrinol Metab 99, E374-378, 2014 (Epub 2013 Nov 25).

Swarts DRA: Molecular profiling of pulmonary carcinoids – insight into tumor biology and identification of prognostic markers. Thesis, 2013.

Swarts DRA, Van Suylen RJ, Den Bakker M, Van Oosterhout MFM, Thunnissen FBJM, Volante M, Dingemans AM, Scheltinga M, Nap M, Bootsma G, Schapers RFM, Pouwels HMM, Klinkhamer P, Van der Borne B, Ramaekers FCS, Speel EJM: Interobserver variability for the WHO classification of pulmonary carcinoids. Am J Surg Pathol, under review.

Name project: Polyomavirus in Merkel cell carcinoma


Project coordinator: G. Cathomas

Other applicants: E. Speel

Applicant address: Department of Pathology, Kantonsspital Liestal Mühlemattstrasse 11, 4410 Liestal, CH Funded by: Swiss Cancer Foundation Sum of contract in Euro’s: CHF 215,000 Sum to person C.V: CHF 107,500 Results: Running Schmidt A, Speel EJM, Willi N, Zsikla V, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Offner F, Sauter G,

Cathomas G: Patterns of MCV in Merkel cell carcinoma (MCC) analyzed by fluorescence in situ hybridization (FISH). 22

nd European Congress of Pathology, September 4-9, 2009, Florence, Italy. Virchows Archiv 455, Suppl 1, S9, 2009

(abstract OP3.2). Speel EJM, Schmidt A, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Willi N, Offner F, Sauter G, Zsikla V,

Cathomas G: A high percentage of Merkel cell carcinomas is biologically associated with Merkel cell polyomavirus. 101

th Annual Meeting of the AACR, April 17-21, 2010, Washington, USA. Proceedings AACR 51, 1297, 2010 (abstract

5352). Haugg AM, Speel EJM, Pantulu ND, Pallasch C, Kurz AK, Kvasnicka HM, Cathomas G, Wendtner C, Zur Hausen A.

Fluorescence in situ hybridisation confirms the presence of Merkel Cell Polyoma Virus in chronic lymphocytic leukemia cells. Blood 117, 5776-5777, 2011.

Name project: Genome-wide identification of epigenetically silenced tumor suppressor genes in pulmonary carcinoids using Methylated CpG Island Recovery Assays



Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Jan Dekker & Ludgardine Bouwman Foundation Sum of contract in Euro’s: € 10,000

19

Sum to person C.V: € 10,000 Results: Swarts DRA, Henfling ME, Van Neste L, Van Suylen RJ, Dingemans AM, Dinjens WNM, Haesevoets A, Rudelius M,

Thunnissen E, Volante M, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: CD44 and OTP are strong prognostic markers for pulmonary carcinoids. Clin Cancer Res 19, 2197-2207, 2013.

Swarts DRA, Van Neste L, Henfling ME, Eijkenboom I, Eijk PP, Van Velthuysen ML, Vink A, Volante M, Ylstra B, Van

Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: An exploration of pathways involved in lung carcinoid progression using gene expression profiling. Carcinogenesis 34, 2726-2737, 2013.

Swarts DRA, ScarpaA, Corbo V, Van Criekinge W, Van Engeland M,


Ramaekers FCS, Speel EJM#, Volante M: MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids. J Clin Endocrinol Metab 99, E374-378, 2014 (Epub 2013 Nov 25).

Swarts DRA: Molecular profiling of pulmonary carcinoids – insight into tumor biology and identification of prognostic markers. Thesis, 2013.

Rapa I, Votta A, Felice B, Righi L, Giorcelli J, Scarpa A, Speel EJM, Scagliotti GV, Papotti M, Volante M: Identification of microRNAs differentially expressed in lung carcinoid subtypes and progression. Submitted for publication

Name project: Chromosomal instability detected by FISH for recognition of head and neck precursor lesions at risk for progression

Period: 2012-present Project coordinator: E. Speel Other participants: B. Kremer Applicant address: Department of Molecular Cell Biology & Pathology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: HFL Cancer Foundation Limburg Sum of contract in Euro’s: €140,000 Sum to person C.V: € 70,000

Results: Fleskens AJHM, Bergshoeff VE, Voogd AC, Van Velthuysen MLF, Bot FJ, Speel EJM, Kremer B, Takes RP, Slootweg PJ.

Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation. Modern Pathol 24, 892-898, 2011.


Sturm B, Fleskens SJ, Bot FJ, van Velthuysen ML, Speel EJM, Slootweg PJ, van der Laak JAWM: Virtual microscopy is a valid alternative for the diagnostic assessment of laryngeal premalignancies. Histopathology 64, 602-604, 2014 (Epub 2013 Nov 6).

Bergshoeff VE, Van der Heijden SJ, Haesevoets A, Litjens SGH, Bot FJ, Voogd AC, Chenault MN, Hopman AHN, Schuuring EMD, Van der Wal JE, Manni JJ, Ramaekers FCS, Kremer B, Speel EJM: Chromosome instability predicts progression of premalignant lesions of the larynx. Pathology 46, 216-224, 2014 (Epub Mar 8).

Bergshoeff VE, Balkenhol MCA, Haesevoets A, Ruland A, Chenault MN, Nelissen RC, Peutz CJ, Nap M, Van der Laak JAWM, Slootweg PJ, Takes RP, Van den Brekel MW, Van Velthuysen MLF, Ramaekers FCS,

Kremer B, Speel EJM:

Evaluation criteria for chromosome instability detection by FISH to predict malignant progression in premalignant glottic laryngeal lesions. In preparation.

Pierssens DDCG, Borgemeester MC, van der Heijden S, Bergshoeff VE, Peutz-Kootstra CJ, Ruland A, Haesevoets A, Kessler P, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of oral cancers is a predictor of local recurrence. In preparation.

Name project: Identification of cell populations with stem cell characteristics in

insulinomas Period: 2012-2017 Project coordinator: J. Mol Other participants: J. Kirpenstein, A. de Bruin, N. Geijsen, F. Verseijden, E. Speel Applicant address: Department of Clinical Sciences of Companion Animals, Faculty of

Veterinary Medicine, UMCU Yalelaan 1, 3584 CL Utrecht, NL Funded by: ZonMW Agiko Stipendia Sum of contract in Euro’s: € 63,530 Sum to person C.V: € 12,706 Results: Buishand FO, Kirpensteijn J, Jaarsma AA, Speel EJM, Kik M, Mol JA: Gene expression profiling of primary canine

insulinomas and their metastases. Vet J 197, 192-197, 2013.

20

Buishand FO, Arkesteijn GJA, Feenstra LR, Oorsprong CWD, Mestemaker M, Starke A, Speel EJM, Kirpensteijn J, Mol JA: Identification of CD90 as putative cancer stem cell marker and therapeutic target in insulinomas. Submitted.

Buishand FO: Canine and human insulinomas, thesis University of Utrecht (defence: January 5, 2016)

Name project: Prognostic and predictive markers in lung neuroendocrine neoplasms identified by multimodal molecular analysis

Period: 2012-2016 Project coordinator: M. Volante Other participants: A. Berruti, E. Duregon, I. Rapa, A. Scarpa, E. Speel Applicant address: Department of Clinical and Biological Sciences, University of Turin,

Regione Conzole 10, Orbassano, Italy Funded by: Associazione Italiana per la Ricerca sul Cancro (AIRC) Sum of contract in Euro’s: € 296,100 Sum to person C.V: € 26,918 Results: Rapa I, Votta A, Felice B, Righi L, Giorcelli J, Scarpa A, Speel EJM, Scagliotti GV, Papotti M, Volante M: Identification of

microRNAs differentially expressed in lung carcinoid subtypes and progression. Neuroendocrinology 101, 246-255, 2015

Name project: Variation analysis of histopathological diagnosis and treatment of large cell neuroendocrine lung carcinoma (LCNEC) in the Netherlands

Period: 2014-present Project coordinator: A. Dingemans Other participants: E. Speel Applicant address: Department of Pulmonology & Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: KWF (Dutch Cancer Society) Sum of contract in Euro’s: € 83,365 Sum to person C.V: € 41,683 Results: Derks JL, Hendriks LE, Buikhuisen WA, Groen HJ, Thunnissen E, van Suylen RJ, Houben R, Damhuis RA, Speel EJM,

Dingemans AC: Clinical features of large cell neuroendocrine carcinoma: a population-based overview. Eur Respir J 2015, in press (Epub Nov 5).

Derks JL, Speel EJM, Dingemans AC: An unmet need in the WHO 2015 biopsy classification: poorly differentiated non-small cell lung carcinomas with positive neuroendocrine markers. Letter to the Editor. J Thorac Oncol 2016, in press.

Derks JL, Speel EJM, Thunnissen E, van Suylen RJ, Buikhuisen WA, van Velthuysen ML, Dingemans AMC: Neuro-endocrine cancer of the lung: a diagnostic puzzle. J Thorac Oncol 2016, in press.

Derks JL, van Suylen RJ, Thunnissen E, den Bakker MA, Smit EF, Groen HJM, Speel EJM#, Dingemans AMC: A population based analysis on application of WHO-nomenclature in pathology reports of pulmonary neuroendocrine tumors. J Thorac Oncol 2016, in press.

Name project: Resection of head and neck lesions: towards the MaaStricht I-knife Period: 2015-present Project coordinator: B. Kremer Other participants: E. Speel, R. Heeren, S. Olde Damink Applicant address: Department of Pathology, MUMC and M4I, UM P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: Horizon 2020 MUMC Sum of contract in Euro’s: €250,000 Sum to person C.V: € 67,500 Results: Will start in 2016

Name project: Prognostic and predictive markers in lung neuroendocrine

neoplasms identified by multimodal molecular analysis: part II

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Period: 2016-2020 Project coordinator: M. Volante Other participants: E. Speel, G. Gatti, I. Rapa, MP Brizzi, A. Scarpa, G. Rindi, S. La Rosa Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: AIRC Sum of contract in Euro’s: € 284,550 Sum to person C.V: € 35,569 Results: Name project: Optimising Access to Personalised Cancer Therapy in the

Netherlands; from Tissue to Therapy (PATH). Period: 2016-2019 Project coordinator: M. Ligtenberg Other participants: E. Speel and many others (Pathology Departments) Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: ZonMW Sum of contract in Euro’s: € 1,138,500 Sum to person C.V: € 56,250 Results: Name project: The Orthopedia Homeobox transcription factor (OTP) in lung

carcinoids: an indicator for recurrence of disease or also a tumor supressor?

Period: 2018-2022 Project coordinator: E. Speel Other participants: A. Dingemans, L. Fernandez-Cuestal Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: KWF (Dutch Cancer Society) Sum of contract in Euro’s: € 498,432 Sum to person C.V: € 498,432 Results: 9. Received funding from industry (per project) Name project: Validation of in situ detection kits for oncogenic HPV types

Period: 2004-2007

Project coordinator: A. Hopman

Co-applicant: E. Speel Applicant address: Department of Molecular Cell Biology, UM P.O. Box 616, 6200 MD Maastricht, NL Funded by: Triple In Tender Fund, Limburg Research Fund Sum of contract in Euro’s: € 13,000 Sum to person C.V: € 6,500 Results:

Hafkamp HC, Manni JJ, Speel EJM: Role of human papillomavirus in the development of head and neck squamous cell carcinomas. Acta Otolaryngol 124, 520-526, 2004.

Klussmann JP, Dinh S, Wittekindt C, Weissenborn S, Wieland U, Dienes HP, Hoffmann T, Smith E, Haugen T, Turek L, Speel EJM, Pfister HJ: HPV associated tonsillar carcinomas: an update. HNO 52, 208-218, 2004.

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Hopman AHN, Smedts F, Dignef W, Ummelen M, Sonke G, Mravunac M, Vooijs GP, Speel EJM, Ramaekers FCS: Transition of high grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J. Pathol. 202, 23-33, 2004.

Hopman AHN, Kamps MAF, Smedts F, Speel EJM, Herrington CS, Ramaekers FCS: HPV in situ hybridization: the impact of different protocols on the detection of integrated HPV. Int. J. Cancer 115, 419-428, 2005.

Hopman AHN, Theelen W, Hommelberg P, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Smedts F, Ramaekers FCS. Genomic integration of oncogenic HPV and gain of the Human Telomerase Gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. J Pathol 210, 412-419, 2006.

Name project: Development of a MLPA test to identify HPV status and genomic instability in HPV-related (pre)malignant lesions

Period: 2007-2009

Project coordinator: G. Simons, Pathofinder

Applicants: A. Hopman, E. Speel Applicant address: Department of Molecular Cell Biology, UM P.O. Box 616, 6200 MD Maastricht, NL Funded by: Triple In Tender Fund, Limburg Research Fund Sum of contract in Euro’s: € 40,000 Sum to person C.V: € 20,000 Results:

Hopman AHN, Theelen W, Hommelberg P, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Smedts F, Ramaekers FCS. Genomic integration of oncogenic HPV and gain of the Human Telomerase Gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. J Pathol 210, 412-419, 2006

Theelen W, Reijans M, Simons G, Ramaekers FCS, Speel EJM, Hopman AHN. A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer 126, 959-975, 2010 (Epub Aug25, 2009).

Theelen W, Speel EJM, Herfs M, Reijans M, Simons G, Ramaekers FCS, Somja J, Delvenne P, Hopman AHN. Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. Am J Pathol 77, 2022-2033, 2010.


Name project: Uterine cervical cancer risk assessment and screening test

Period: 2009-2011

Project coordinator: G. Simons, Pathofinder

Applicants: A. Hopman, E. Speel, R. Kruitwagen Applicant address: Department of Molecular Cell Biology, MUMC P.O. Box 616, 6200 MD Maastricht, NL Funded by: Company-directed Arrangement OP-Zuid Sum of contract in Euro’s: € 350,000 Sum to person C.V: € 116,000 Results:


Litjens JNTM, Theelen W, Van de Pas Y, Ossel J, Reijans M, Simons G, Speel EJM, Slangen BFM, Ramaekers FCS, Kruitwagen RFPM, Hopman AHN: Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions. J Med Virol 85, 1386-1393, 2013.

Theelen W, Litjens JNTM, Vinokurova S, Haesevoets A, Reijans M, Simons G, Smedts F, Herrington CS, Ramaekers FCS, Von Knebel Doeberitz M, Speel EJM, Hopman AHN: Human papillomavirus multiplexligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies. Human Pathol 44, 2410-2418, 2013.

Name project: European Thoracic Oncology Platform (ETOP) Lungscape Period: 2012-now

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Project coordinator: R. Stahel, S. Peters Applicants: 20 European labs including MUMC+ (E. Speel, A. Dingemans) Applicant address: Department of Pathology & Pulmonology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: Different companies (Novartis, Roche, Pfizer etc.) Sum of contract in Euro’s: € 30,000 Sum to person C.V: € 15,000 Results: Blackhall FH, Peters S, Bubendorf L, Dafni U, Kerr KM, Hager H, Soltermann A, O'Byrne KJ, Dooms C, Sejda A,

Hernández-Losa J, Marchetti A, Savic S, Tan Q, Thunnissen E, Speel EJM, Cheney R, Nonaka D, de Jong J, Martorell M, Letovanec I, Rosell R, Stahel RA: Prevalence and clinical outcomes for patients with ALK-positive resected stage I-III adenocarcinoma: Results from the European Thoracic Oncology Platform Lungscape Project. J Clin Oncol 32, 2780-2787, 2014

Peters S, Weder W, Dafni U, Kerr KM, Bubendorf L, Meldgaard P, O'Byrne KJ, Wrona A, Vansteenkiste J, Felip E, Marchetti A, Savic S, Lu S, Smit E, Dingemans AM, Blackhall FH, Baas P, Camps C, Rosell R, Stahel RA; ETOP Lungscape Investigators (including Speel EJM). Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters. J Thorac Oncol 9, 1675-1684, 2014

Name project: In vitro efficacy of the PI3K inhibitors BYL719 and BKM120 and CDK inhibitor LEE011 in (human papilloma virus associated) head and neck squamous cell carcinoma.

Period: 2014-now Project coordinator: A. Houben, B. Kremer Applicants: E. Speel, I. Cornet, K. Rouschop, F. Hoebers Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: Novartis Sum of contract in Euro’s: € 22,500 + use of inhibitors free of costs Sum to person C.V: € 11,250 Results: Cornet I, Kremer B, Calon T, Roemen G, Straetmans J, Speel EJM: PIK3CA mutations occur more frequently in human

papillomavirus-containing oropharyngeal carcinomas and are associated with poor overall survival. Abstract 5th World Congres of the IFHNOS, New York, USA, July 26-30, 2014

Cornet I, Kremer B, Kok G, Speel EJM: Effectiviteit van cidofovir behandeling op humaan papillomavirus-positieve en –negatieve hoofd-hals carcinoom cellijnen in vitro. Abstract 225e KNO Dagen, Nieuwegein, November 20, 2014

Verhees F, Cornet I, Hoebers F, Hoeben A, Speel EJM, Kremer B: The PIK3CA-inhibitor BYL719 is an effective growth inhibitor in head and neck squamous cell carcinoma cell lines, independent of the HPV status. Abstract 226e KNO Dagen, Nieuwegein, April 23, 2015

Name project: Efficacy of PI3K pathway and CDK4/6 inhibitors on HNSCC cell lines Period: 2015-now Project coordinator: E. Speel Applicants: B. Kremer Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: Pfizer Sum of contract in Euro’s: € 34,200 + use of inhibitors free of costs Sum to person C.V: € 17,100 Results: Will start in January 2016

Name project: Optimizing the assessment of PDL1 expression in non small cell lung cancer using immunohistochemistry (PEPSI)

Period: 2016-now Project coordinator: M. van den Vijver Applicants: E. Speel, T. Bosse, J. van der Thusen, W. Timens, E. Thunnissen Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: MSD

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Sum of contract in Euro’s: € 40,000 + use of PDL1 antibodies and materials free of costs Sum to person C.V: € 6,667 Results:

Name project: A Multi-Center Retrospective Observational Study to Evaluate PD-L1 Protein Expression in Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (EXPRESS)

Period: 2016-2018 Project coordinator: E. Speel Applicants: A. Dingemans Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: MSD Sum of contract in Euro’s: € 20,132 + use of PDL1 antibodies and materials free of costs Sum to person C.V: € 20,132 Results:

Name project: Batch re-testing for MET exon 14 skipping mutation Period: 2016-2018 Project coordinator: E. Speel Applicants: A. Dingemans Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: Novartis Sum of contract in Euro’s: € 18,900 Sum to person C.V: € 18,900 Results:

Name project: Implementation of liquid biopsy analyses of lung tumor patients in the MUMC+ and the regional network OncoZON

Period: 2018-2019 Project coordinator: E. Speel Applicants: A. Dingemans, G. Roemen Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: AstraZeneca Sum of contract in Euro’s: €180,290 Sum to person C.V: € 180,290 Results:

Name project: Identification Of Molecular Subgroups of Pulmonary Large Cell Neuroendocrine Carcinoma (LCNEC) and correlation with PD-L1 expression in Stage IV Disease.

Period: 2018-2019 Project coordinator: A. Dingemans Applicants: E. Speel, J. Derks Applicant address: Department of Pathology, MUMC P.O. Box 5800, 6202 AZ Maastricht, NL Funded by: BMS Sum of contract in Euro’s: € 27,626 Sum to person C.V: € 9,209 Results:

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Valorisation/patents

Name patent: In vitro method for determining disease outcome in pulmonary carcinoids

International publication nr: WO 2013/ 131933 A1 (Patent Cooperation Treaty) Published: 12-09-2013 Agent: WJA Habets

Inventors: FCS Ramaekers, DRA Swarts, EJM Speel Inventors address: UM: Minderbroedersberg 4-6, 6211 LK Maastricht NL MUMC: P. Debyelaan 25, 6202 AZ Maastricht NL 10. Cooperations and current projects Name project: Identification of endocrine pancreatic tumor-promoting genes and development of

a molecular test to predict malignancy and prognosis Partners: R. Riedl, Pathology, MUMC

B Havekes, NC Schaper, Internal Medicine, MUMC C de Jong, Surgery, MUMC AC Voogd, Epidemiology, MUMC LJ Hofland, WW de Herder, Internal Medicine, ErasmusMC Rotterdam RR de Krijger, Pathology, SSDZ, Delft B Kuesters, PJ Slootweg, Pathology, Radboud UMC, Nijmegen R Hermus, Endocrinology, Radboud UMC, Nijmegen JA Kummer, Pathology, St. Anthonius Hospital, Nieuwegein G Valk, Internal Medicine, UMC Utrecht F Buishand, JA Mol, J Kirpensteijn, Veterinary Medicine, University of Utrecht A Perren, Pathology, University of Bern, Switzerland P Komminoth, Pathology, Triemli Hospital Zurich, Switzerland G. Klöppel, Pathology, University of Munich, Germany A Starke, C Saddig, P Goretzky, Internal Medicine, University of Dusseldorf,

Germany M Volante, Clinical and Biological Sciences, University of Turin, Italy

B Skogseid, Medical Sciences, University of Uppsala, Sweden WL Lam, Cancer Genetics and Developmental Biology, British Columbia Cancer

Research Center, Vancouver, Canada Period: 2007-present Funded by: Kootstra Fellowship, Dutch Digestion Foundation Postdoc: YMH Jonkers Technician: M Henfling, A Ruland Advisors: FCS Ramaekers, AHN Hopman, A zur Hausen Name project: Identification of lung carcinoid-promoting genes and development of a molecular

test to predict malignancy and prognosis Partners: M Bendek, Pathology, MUMC M van Engeland, L van Neste, Pathology, MUMC A Dingemans, Pulmonology, MUMC AC Voogd, Epidemiology, MUMC RJ van Suylen, Pathology, Jeroen Bosch Hospital, 's-Hertogenbosch

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M. Scheltinga, Surgery, Maxima Medical Center Veldhoven LJ Hofland, WW de Herder, Internal Medicine, ErasmusMC Rotterdam M den Bakker, Pathology, Maasstad Hosptal, Rotterdam

RR de Krijger, Pathology, SSDZ, Delft B. Kuesters, PJ Slootweg, Pathology, Radboud UMC, Nijmegen JA Kummer, M van Oosterhout, Pathology, St. Anthonius Hospital, Nieuwegein A Vink, Pathology, UMC Utrecht M. van Velthuijsen, Pathology, AvL/NKI, Amsterdam E Smit, Pulmonology, VUmc, Amsterdam E Thunnissen, Pathology, VUmc, Amsterdam W Timens, Pathology, UMC Groningen A Perren, Pathology, University of Bern, Switzerland M Rudelius, G Klöppel, Pathology, Klinikum Rechts der Isar, Munich, Germany

P Komminoth, Pathology, Triemli Hospital Zurich, Switzerland B Skogseid, Medical Sciences, University of Uppsala, Sweden

M Volante, Clinical and Biological Sciences, University of Turin, Italy W van Criekinge, University of Gent, Belgium

Period: 2008-present Funded by: Foundation Vanderes, GROW-School for Oncology & Developmental Biology, Foundation “Drie Lichten”, Jan Dekker & Ludgardine Bouwman Foundation, ETOP

Lungscape PhD student: DRA Swarts, J Derks Technician: M Henfling, A Haesevoets Advisors: FCS Ramaekers, AHN Hopman, A zur Hausen Name project: European Thoracic Oncology PIatform (ETOP) Lungscape Partners: A Dingemans, Pulmonology, MUMC M Bendek, Pathology, MUMC E Smit, Pulmonology, VUmc, Amsterdam E Thunnissen, Pathology, VUmc, Amsterdam P Baas, Pulmonology, NKI/AvL, Amsterdam J. de Jong, Pathology, NKI/AvL, Amsterdam R Stahel, Internal medicine, Zurich, CH S Peters, Internal Medicine, Lausanne, CH K Kerr, Pathology, Aberdeen, UK others Period: 2012-now

Funded by: Industry (Pfizer, Novartis, Roche & others), ETOP

Technician: G Roemen, A Ruland, T Pirens, S Timmermans Name project: Impact of virus integration, chromosomal instability and deregulated gene

expression on the development and progression of HPV-related tumors Partners: C Peutz, L Kooreman, Pathology, MUMC AHN Hopman, FCS Ramaekers, Molecular Cell Biology, MUMC

B Kremer, Otorhinolaryngology, Head and Neck Surgery, MUMC R Kruitwagen, AJ Kruse, Gynaecology, MUMC GPH Lucker, P. Steijlen, Dermatology, MUMC AC Voogd, Epidemiology, MUMC

G. Simons, Pathofinder, Maastricht

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F. Kwaspen, PanPath, Budel B Braakhuis, RH Brakenhoff, Otorhinolaryngology, VUmc, Amsterdam PJ Slootweg, Pathology, Radboud UMC, Nijmegen R Takes, Otorhinolaryngology, Head and Neck Surgery, Radboud UMC,

Nijmegen S Willems, Pathology, UMC Utrecht JA Kummer, Pathology, St. Anthonius Hospital, Nieuwegein M van den Brekel, F Balm, Otorhinolaryngology, Head and Neck Surgery, AvL/NKI, Amsterdam M. van Velthuijsen, Pathology, AvL/NKI, Amsterdam F Smedts, Pathology, SSDZ, Delft

E Schuuring, Pathology, UMC Groningen JP Klussmann, Otorhinolaryngology, Head and Neck Surgery, University of

Giessen, Germany C Huebbers, S Preuss, Otorhinolaryngology, Head and Neck Surgery, University

of Cologne, Germany M von Knebel Duborietz, Pathology, University of Heidelberg, Germany D Holzinger, J Hess, Otorhinolaryngology, University of Heidelberg, Germany T Hoffmann, Otorhinolaryngology, University of Ulm, Germany

CS Herrington, Pathology, Dundee, UK T Carey, Otorhinolaryngology, University of Michigan, Ann Arbor, USA S Gollin, Human Genetics, Otorhinolaryngology, University of Pittsburgh, USA WL Lam, Cancer Genetics and Developmental Biology, British Columbia Cancer

Research Center, Vancouver, Canada Period: 2005-present Funded by: Foundation Scientific Research Otorhinolaryngology Maastricht, Transnational

University Limburg/Molecular Life Sciences, Triple In Tender Fund/Limburg Research Fund, Company-directed Arrangement OP-Zuid, PanPath, Kootstra Fellowship

PhDs: HC Hafkamp, W Theelen, NC Olthof, JJ Mooren, JMJAA Straetmans Technicians: A Haesevoets, SMH Claessen, M Henfling, T Pirens, S Hulsmans Students: B Klingenberg, Z. Mujagic, V. Vastmans, M. Vervoort Name project: Therapeutic potential of novel antiviral strategies in combination with

radiotherapy for the treatment of human papillomavirus-related oropharyngeal cancer

Partners: A Zur Hausen, A Haugg, C Peutz, Pathology, MUMC AHN Hopman, FCS Ramaekers, Molecular Cell Biology, MUMC

B Kremer, I Cornet, Otorhinolaryngology, Head and Neck Surgery, MUMC Ph. Lambin, K. Rouschop, F. Hoebers, Maastro Clinic, MUMC A Hoeben, Internal Medicine, MUMC AC Voogd, Epidemiology, MUMC B Braakhuis, RH Brakenhoff, Otorhinolaryngology, VU MC, Amsterdam PJ Slootweg, Pathology, Radboud UMC, Nijmegen R Takes, Otorhinolaryngology, Head and Neck Surgery, Radboud UMC,

Nijmegen L Hofland, P v Koetsveld, Internal Medicine, Erasmus UMC, Rotterdam F Smedts, Pathology, SSDZ, Delft

F. Kwaspen, PanPath, Budel JP Klussmann, Otorhinolaryngology, Head and Neck Surgery, University of Giessen, Germany

C Huebbers, S Preuss, Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Germany

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T. Hoffmann, Otorhinolaryngology, University of Ulm, Germany T. Carey, Otorhinolaryngology, University of Michigan, Ann Arbor, USA S. Gollin, Human Genetics, Otorhinolaryngology, University of Pittsburgh, USA R. Snoeck, G. Andrei, Rega Institute, University of Leuven, Belgium J Hess, Otorhinolaryngology, University of Heidelberg, Germany

CS Herrington, Pathology, Dundee, UK Period: 2007-present Funded by: MUMC, GROW Post-doc: I Cornet PhD: NC Olthof, JMJAA Straetmans, JJ Mooren Technician: A Haesevoets, SMH Claessen, M Henfling, S Timmermans, T Pirens Student: P Wolber Name project: Chromosomal instability detected by FISH for recognition of head and neck

precursor lesions at risk for progression and for prediction of recurrence in head and neck tumor resection margins

Partners: C Peutz, Pathology, MUMC AHN Hopman, FCS Ramaekers, Molecular Cell Biology, MUMC

JJ Manni, B Kremer, Otorhinolaryngology, Head and Neck Surgery, MUMC P Kessler, Oral and Maxillofacial Surgery, MUMC

AC Voogd, Epidemiology, MUMC PJ Slootweg, J van der Laak, Pathology, Radboud UMC, Nijmegen R Takes, Otorhinolaryngology, Head and Neck Surgery, Radboud UMC,

Nijmegen M Merkx, Oral and Maxillofacial Surgery, Radboud UMC, Nijmegen L van Velthuijsen, Pathology, NKI, Amsterdam M van de Brekel, F Balm, Otorhinolaryngology, Head and Neck Surgery,

AvL/NKI, Amsterdam B Braakhuis, JP Klussmann, Otorhinolaryngology, Head and Neck Surgery, University of

Giessen, Germany N Gale, Pathology, University of Ljubljana, Slovenia Period: 2008-present Funded by: Medical Research Foundation MUMC, Dutch Cancer Foundation, HFL Cancer

Foundation Limburg Post-doc: I Cornet PhD: VE Bergshoeff, M Borgemeester, D Pierssens, S van der Heijden, S Fleskens

(Nijmegen), T Siebers (Nijmegen) Technicians: A Haesevoets, SMH Claessen, A Ruland Students: IR Zwijnenberg, S Litjens, N van Attekum, R Hamers, S van der Heijden, M

Balkenhol Name project: The role of interferon and interferon receptors in the pathogenesis and therapy of

adrenocortical carcinomas Partners: LJ Hofland, WW de Herder, SWJ Lamberts, RA Feelders, K van der Wansem, M

Waaijers, Internal Medicine, ErasmusMC, Rotterdam RR de Krijger, Pathology, SSDZ, Delft HJ Bonjer, CAJ van Eijck, Surgery, ErasmusMC, Rotterdam E Croze, Immunology, Berlex Bioscience, Richmond, USA

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Period: 2005-present Funded by: Foundation Vanderes, ErasmusMC Postdoc: G Vitale (Rotterdam) PhD: P van Koetsveld (Rotterdam) Technician: SMH Claessen, M Henfling, D Mooi-Sprij Name project: Identification of pheochromocytoma-promoting genes and development of a

molecular test to predict malignancy and prognosis Partners: WNM Dinjens, Pathology, ErasmusMC, Rotterdam LJ Hofland, WW de Herder, Internal Medicine, ErasmusMC Rotterdam RR de Krijger, Pathology, SSDZ, Delft B Kusters, Pathology, Radboud UMC, Nijmegen A Perren, Pathology, University of Bern, Switzerland P Komminoth, Triemli Hospital, Zurich, Switserland

WL Lam, Cancer Genetics and Developmental Biology, British Columbia Cancer Research Center, Vancouver, Canada

Period: 2006-2013 Funded by: Foundation Vanderes, ErasmusMC, AGIKO PhDs: F van Nederveen, BJ Petri, E Korpershoek (Rotterdam) Technician: SMH Claessen Name project: Development and implementation of molecular diagnostic tests to detect and/or

classify cancer cells, to predict prognosis and the efficacy of treatments Partners: R Riedl, C Peutz, L Kooreman, B de Vries, M Bendek, V Winnepenninckx, A zur

Hausen, Pathology, MUMC C van de Beek, Urology, MUMC A Dingemans, Pulmonology, MUMC J Janssen, S Stegman, M MacVille, R Blok, B Smeets, J Veltman, H Brunner, Clinical Genetics, MUMC V Tjan-Heijnen, P Soetekouw, R Janssen, Internal Medicine, MUMC D de ruysscher, Radiotherapy, KU Leuven, Belgium Ph Lambin, F Hoebers, Maastro Clinic, MUMC B Kremer, K Kross, Otorhinolaryngology, Head and Neck Surgery, MUMC M. van Steensel, M. Thissen, Dermatology, MUMC P Savelkoul, P Wolffs, Medical Microbiology, MUMC M Tilanus, C Voorter, Transplantation Tissue Typing, MUMC A de Bruïne, A van Marion, S Wouda, Pathlogy, Vie Curi MC, Venlo D Rupa, A Willig, B Lohman, Laurentius Hospital, Roermond W Vos, P Satrowijoto, S Corvers, H Plasschaert, Pathology, Orbis MC, Sittard R Clarijs, P Theunissen, N vandevijver, M Nap, Pathology, Atrium MC, Heerlen WNM Dinjens, Pathology, ErasmusMC, Rotterdam A van den Brule, Pathology, Jeroen Bosch Hospital, 's-Hertogenbosch E Thunnissen, D Heideman, PJ Snijders, Pathology, Vumc, Amsterdam EMD Schuuring, Pathology, UMC Groningen S Willems, J Hinrichs, Pathology, UMC Utrecht J Jeuken, Pathology, PAMM, Eindhoven C Prinssen, Pathology, CWZ, Nijmegen M Ligtenberg, P Groen, B Tops, H van Krieken, Pathology, St Radboud MC Nijmegen

S Riemersma, Pathology, Enschede D Creytens, Pathology, University of Ghent, Belgium

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J Benhattar, Pathology, CHUV, Lausanne, Switzerland G Simons, Pathofinder, Maastricht

Period: 2005-present Researcher: C Huysentruyt, L Kooreman, I Verlinden, B de Vries Technician: A Ruland, G Roemen, J Peeters, T Pirens, S Hulsmans, S Timmermans, R Tonk,

P Vervoort, A Haesevoets Students: Several Name project: Polyomavirus-induced cancer. Partners: A zur Hausen, A Haugg, J Becker, V. Winnepenninckx, Pathology, MUMC

P Steijlen, M van Steensel, M Thissen, Dermatology, MUMC G Cathomas, A Schmidt, Pathology, Kantonspital Liestal, Switzerland G Sauter, Academic Hospital Hamburg-Eppendorf, Germany ND Pantulu, University Hospital Freiburg, Germany C Pallasch, C Wendtner, University Hospital Cologne, Germany AK Kurz, University Hospital Aachen, Germany HM Kvasnicka, University Hospital Frankfurt, Germany JC Becker, D Schrama, Medical University of Graz, Austria C Huebbers, S Preuss, University of Cologne, Germany

T. Carey, Otorhinolaryngology, University of Michigan, Ann Arbor, USA Period: 2009-present Researcher: A Haug, I Cornet, A Paivonen (Liestal), L Hillen PhD Student: S Pujari Technician: D Rennspiess, R Plusquin, A Ruland, A Haesevoets, A Stalder (Liestal) Name project: Detection of biomarkers in resection margins to predict recurrence of breast

carcinomas in young women. Partners: B de Vries, K van den Vijver, Pathology, MUMC AC Voogd, Epidemiology, MUMC

V Tjan-Heijnen, Internal Medicine, MUMC C Tutein, Pathology, Elkerliek Ziekenhuis Helmond

M van Beek, Stichting PAMM, Eindhoven Period: 2010-present Technician: A Haesevoets Students: L Hillebrand, N Rekers 11. Main research themes My research focuses on the identification of genomic and phenotypic alterations involved in the pathogenesis of head and neck squamous cell carcinomas (HNSCC) and tumors of endocrine organs, and on translational research resulting in new molecular diagnostic approaches to be applied in the clinic. Head and neck cancer Tobacco and alcohol use are well-known risk factors for tumor development in the head and neck mucosa. As a result, already in precursor lesions of the head and neck mucosa genetic and phenotypic alterations can be detected. We have shown that the occurrence of chromosome instability in premalignant lesions of both the oral cavity and larynx strongly correlates with a poor prognosis (malignant outgrowth or tumor recurrence), whereas histopathological assessment is

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unreliable to predict the risk of progression in these early precursor lesions. If this holds through after analysis of large series of laryngeal and oral lesions, which is currently undertaken, this procedure will be implemented in clinical practice to improve patient management. In addition, we have proved that high risk human papillomavirus is present in 10-20% of HNSCC (up to 50% of oropharngeal carcinomas in 2011), and showed that these tumors comprise a separate entity with specific clinical and molecular features. We are currently using genomic, microarray, next generation sequencing and molecular (cyto)genetic technologies to identify biomarkers that can reliably predict prognosis and malignant progression and we are examining new therapeutical opportunities (amongst others, anti-viral strategies incombination with radiotherapy) to improve patient treatment. Neuro-endocrine cancer The molecular pathogenesis of neuro-endocrine tumors, including endocrine pancreatic tumors (EPTs), bronchial carcinoids, pheochromocytomas and adrenocortical tumors, is not well understood, and the clinical behavior of these tumors is difficult to predict using current morphological criteria. Moreover, a substantial proportion of tumors is unresectable and responds unpredictably to palliative therapy. We are using genomic, microarray, next generation sequencing and molecular (cyto)genetic technologies to assess chromosomal alterations, deregulated gene expression and promoter hypermethylation underlying the development and progression of these tumors. This research will pinpoint candidate cancer genes, improve our understanding of the involved cell signalling pathways and will pave the way for the identification of novel targets for therapeutical intervention and more reliable markers for clinical diagnosis and prognosis. In this respect we have initiated in 2009 studies on the recently discovered Merkel Cell Polyoma Virus (MCPyV) in non-melanocytic skin cancers, such as Merkel Cell carcinoma, to compare different MCPyV detection technologies as well as the impact of viral integration on tumor behavior. Molecular Diagnostics Translational research projects have been initiated in order to assess the efficacy and cost effectiveness of new molecular diagnostic DNA tests in the clinic, including FISH and PCR tests to detect (recurrent) bladder cancer (UroVysion), melanoma, progressive premalignant and recurrent head and neck lesions and HPV-related cancer. Furthermore, research have been initiated to determine the efficacy of DNA tests as indicator for molecular targeted therapies, including K-Ras and EGFR mutational analysis, and ALK and ROS1 rearrangement analysis for NSCLC (also as part of the European Thoracic Oncology Platform Lungscape project), cKIT/PDGFRa mutation analysis for GIST, BRAF, NRAS and cKIT mutation analysis for melanoma, and MGMT methylation analysis for gliomas. In addition, research is initiated to implement new sequencing technologies in the molecular diagnostics lab for multitarget exon sequencing (pyrosequencing, next generation sequencing platforms). 12. Memberships, advisory boards, external reviewer, organization congress session

a. Associations/Societies

Netherlands Society for Pathology (NVVP) (since 2012) Netherlands Society for Molecular Diagnostics in Health (NVDG) (since 2013) European Society for Pathology (ESP) (since 2011) European Thoracic Oncology Platform (ETOP) (since 2011) Association for Molecular Pathology (AMP) (since 2010) American Association for Cancer Research (AACR) (active member since 1999) European NeuroEndocrine Tumor Society (ENETS) (since 2006) American Society for Clinical Oncology (ASCO) (since 2016) Netherlands Ear Nose Throat Society (KNO Vereniging) (since 2017) Histochemical Society USA (1997-2005) Society for Histochemistry (1997-2005)

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Netherlands Society for Biochemistry and Molecular Biology (1992-2005)

b. Working groups Lungscape working group, European Thoracic Oncology Platform (since 2011) NVVP committee molecular diagnostics in pathology (since 2012) - QC committee (since 2013; Chairman since 2015) - HPV-QC committee (since 2012) Committee Quality and Professional Performance of the NVVP (since 2017) SKML-section Pathology (since 2015, interim chairman in 2017)

ESP Steering Committee Molecular Pathology (since 2014) Working group on pathology (IKNL 2011-2015) Working group on lung tumors (IKNL 2011-2015; OncoZON since 2015) Working group on head and neck tumors (IKNL/OncoZON since 2005) Netherlands working group on head and neck tumors (since 2004)

c. Advisory Boards Pfizer Advisory Board on lung carcinoma (since 2011) Roche Advisory Board on lung carcinoma (since 2013) Amgen Advisory Board on colorectal cancer (since 2013) MSD Advisory Board on lung carcinoma (since 2015) BMS Advisory Board on lung carcinoma (since 2015) AbbVie Advisory Board on lung carcinoma and DLL3 (since 2017)

d. Editorial Boards

Journal of Histochemistry and Cytochemistry (1999-2005)

International Journal of Experimental and Clinical Pathology (since 2010) World Journal of Clinical Oncology (since 2010)

e. External reviewer for (since 1995):

IARC Italy Bernese Cancer League Cancer Research UK Dutch Cancer Society (KWF) Federation for Scientific Research Flanders (FWO) French National Cancer Institute (INCa) ZonMW American Journal of Pathology

Anti-virus Research BMC Cancer

Biotechniques Clinical Microbiology and Infection

Cytogenetic and Genome Research Endocrine-Related Cancer Experimental Cell Research

Head and Neck Histochemistry and Cell Biology Genes Chromosomes and Cancer Histochemical Journal Infectious Agents and Cancer

International Journal of Cancer

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International Journal of Experimental Pathology International Journal of Experimental and Clinical Pathology

Journal of Clinical Virology Journal of Histochemistry and Cytochemistry

Journal of Immunological Methods Journal of Medical Virology Journal of Pathology Lung Cancer Molecular Cancer

Netherlands Journal for Oncology Oncotarget

Otorhinolaryngology Scientific Reports

Virchows Archiv World Journal of Clinical Oncology

f. Organization/Chairman scientific meetings/sessions/workshops Organization and Chairman minisymposium “Endocrine (pancreatic) tumorigenesis and new treatment opportunities”. June 14, 2007, Maastricht, The Netherlands Organization and Chairman session “New developments in the molecular oncogenesis of head and neck tumors”. 213

th General Meeting of the Netherlands Society of Otorhinolaryngology and Head and

Neck Surgery, November 13-14, 2008, Maastricht, The Netherlands Organization and Chairman annual scientific workshop “Molecular Oncology”, held at the Department of Pathology, MUMC, The Netherlands (April 3, 2009; November 5, 2010). Chairman session “Basic Science II”. 2

nd World Congress of the International Academy of Oral Oncology, July 8-11, 2009,

Toronto, Canada. Organization and Chairman Molecular Abbott scientific meeting “Urovysion”. June 22, 2010, Utrecht, The Netherlands. Organization “Nederlandse Werkgroep Hoofd-Hals Tumoren Research Meeting” and Chairman session “Oropharyngeal carcinoma and HPV” October 14-15, 2010, Maastricht, The Netherlands. Chairman session “Invasion/metastasis: models and applications”. American Head and Neck Society (AHNS) 2010 Research workshop on the Biology, Prevention and Treatment of Head & Neck Cancer, October 28-30, 2010, Arlington, USA. Organization and Chairman minisymposium “Molecular diagnostics: The next generation”. February 1, 2013, Maastricht, The Netherlands Organization symposium "Molecular diagnostics guiding cancer treatment: state of the art and future perspectives" October 11, 2013, Maastricht, The Netherlands Member AMP Annual Meeting 2013 Program Committee (Solid Tumor subdivision) Organization AMP Annual Meeting 2013 Solid Tumor sessions program

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November 14-16, 2013, Phoenix, AZ, USA Member ECP Steering Committee Molecular Pathology, organization and reviewing abstracts for oral presentation and poster session Molecular Pathology at the 26th European Congress of Pathology (ECP) August 30-September 3, 2014, London, UK Member ECP Steering Committee Molecular Pathology, organization and reviewing abstracts for oral presentation and poster session Molecular Pathology, Chairman Poster Reviewing Committee Molecular Pathology at the 27th European Congress of Pathology (ECP) September 5-9, 2015, Belgrade, SRB Scientific Committee of the European Meeting on Molecular Diagnostics (EMMD) 2015, organization and chairman of the "Molecular Diagnostics in Oncology" session program October 14-16, 2015, Noordwijk, The Netherlands Organizing committee of the Annual SKML-section Pathology meeting, and (Chairman of the) Next Generation Sequencing Users Day May 26, 2016, Amersfoort, The Netherlands Organizing and scientific committee of the 8th International Conference of HPV & Polyomavirus in skin cancer November 16-18, 2016, Maastricht, The Netherlands Member 1st AMP Global Meeting 2017 Program Committee (Solid Tumor subdivision) Organization AMP Global Meeting 2017 Tissue sections program and organization and chairman of the session "Clonal evolution and heterogeneity of solid tumors" April 3-5, 2017, Berlin, Germany Member ECP Steering Committee Molecular Pathology, organization and reviewing abstracts for oral presentation and poster session Molecular Pathology, at the 29th European Congress of Pathology (ECP) September 2-6, 2017, Amsterdam, The Netherlands Scientific Committee of the European Meeting on Molecular Diagnostics (EMMD) 2017, organization and chairman of the "Molecular Diagnostics in Oncology" session program October 11-13, 2017, Noordwijk, The Netherlands Member 1st AMP Europe 2018 Program Committee Organization AMP Europe 2018 general program and chairman "liquid biopsies" and "biological themes across tumor types" session program April 30-May 2, 2018, Rotterdam, The Netherlands Scientific committee of the Joint meeting of the Pathological Society of Great Britain & Ireland and the Dutch Pathological Society, Summer Meeting 2018, organization and chairman of the "lung pathology" session program June 18-22, 2018, Maastricht, The Netherlands

13. Thesis promotorship and supervision Supervision (1997-1999) and delivered MD theses at the Department of Pathology, University of Zurich, Zurich, Switzerland:

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MSc. D. Bachmann (2002): Deletion of chromosome 3p in sporadic endocrine pancreatic tumors: a FISH analysis on 37 tumors.

MSc. B. Farspour (2002): Putative tumor suppressor genes on 6q22 and 6q23-q24 are associated with malignant progression of sporadic endocrine pancreatic tumors.

MSc. D. Meier (2004): Differential deletions of chromosome 11 in sporadic endocrine pancreatic tumors and neuro-endocrine tumors. Evidence for a second tumor suppressor gene distal of MEN1.

Supervision and (co-)promotorship at the Department of Molecular Cell Biology, MUMC (until 2011) and at the Department of Pathology, MUMC (since 2011), in collaboration with the Departments of Otorhinolaryngology and Head and Neck Surgery, Internal Medicine, Oral and Maxillofacial Surgery, Pulmonology and Surgery, MUMC, The Netherlands:

Dr. A.J. van der Wouw (Maastricht, July 1, 2005): Unknown primary tumor Promotor: Prof. Dr. H.F.P. Hillen, Co-promotor: Dr. E.J.M. Speel, Dr. R.L.H. Jansen Dr. Y.M.H. Jonkers (Maastricht, June 14, 2007): Molecular alterations during insulinoma

tumorigenesis Promotor: Prof. Dr. F.C.S. Ramaekers, Co-promotor: Dr. E.J.M. Speel Dr. H.C. Hafkamp (Maastricht, February 6, 2009): The role of human papillomavirus in the

development of tonsillar squemous cell carcinomas Promotor: Prof. Dr. J.J. Manni, Prof. Dr. F.C.S. Ramaekers, Co-promotor: Dr. E.J.M. Speel Dr. W. Theelen (Maastricht, December 20, 2011) Promotor: Prof. Dr. F.C.S. Ramaekers, Co-promotor: Dr. E.J.M. Speel, Dr. A.H.N.

Hopman Dr. N.C. Olthof (Maastricht, December 3, 2013) Promotors: Prof. Dr. B. Kremer, Prof. Dr. F.C.S. Ramaekers, Prof. Dr. E.J.M. Speel Dr. D.R.A. Swarts (Maastricht, December 19, 2013) Promotors: Prof. Dr. F.C.S. Ramaekers, Prof. Dr. E.J.M. Speel, Prof. Dr. M. van Engeland Dr. J.J. Mooren, MD (Maastricht, December 16, 2014) Promotors: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel, Prof. Dr. F.C.S. Ramaekers Dr. V.E. Bergshoeff, MD (Maastricht, June 15, 2017) Promotors: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel, Prof. Dr. F.C.S. Ramaekers Dr. J Derks (Maastricht, December 8, 2017) Promotor: Prof. Dr. A. Dingemans, Prof. Dr. E.J.M. Speel MSc. S. Pujari (thesis to be delivered in 2018) Promotor: Prof. Dr. A. zur Hausen, Prof. Dr. E.J.M. Speel MSc. J.M.J.A.A. Straetmans, MD (thesis to be delivered in 2018) Promotors: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel MSc. M. Borgemeester (thesis to be delivered in 2019) Promotor: Prof. Dr. B. Kremer, Prof. Dr. M. van den Brekel, Prof. Dr. E.J.M. Speel MSc. D. Pierssens (thesis to be delivered in 2019) Promotor: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel, Prof. Dr. P. Kessler MSc. M. Stuut (thesis to be delivered in 2019) Promotor: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel MSc. F. Verhees (thesis to be delivered in 2019) Promotor: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel MSc. E. Chteinberg (thesis to be delivered in 2019) Promotor: Prof. Dr. A. zur Hausen, Prof. Dr. E.J.M. Speel MSc. L. Vaessen (thesis to be delivered in 2020) Promotor: Prof. Dr. P. Kessler, Prof. Dr. E.J.M. Speel MSc. P. Maxence (thesis to be delivered in 2020) Promotor: Prof. Dr. R. Heeren, Prof. Dr. S. Olde Damink, Prof. Dr. B. Kremer, Prof. Dr.

E.J.M. Speel MSc. F. Mulder (thesis to be delivered in 2021) Promotor: Prof. Dr. B. Kremer, Prof. Dr. E.J.M. Speel PhD vacancy KWF project (thesis to be delivered in 2022)

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Promotor: Prof. Dr. E.J.M. Speel, Prof. dr. A. Dingemans PhD vacancy project HNSCC (thesis to be delivered in 2022) Promotor: Prof. Dr. B. Kremer, Prof. dr. E.J.M. Speel PhD vacancy project LCNEC (thesis to be delivered in 2022) Promotor: Prof. dr. A. Dingemans, Prof. dr. E.J.M. Speel Participation in manuscript committee and thesis defence: Dr. M. Bierskens, VUmc, Amsterdam (thesis defence January 22, 2013) Dr. I. Kuijpers, MUMC, Maastricht (thesis defence March 21, 2013) Dr. T. de Schutter, Catholoic University Leuven, België (thesis defence June 26, 2013) Dr. R. Huijsmans, VUmc, Amsterdam (thesis defence October 22, 2013) Dr. A Loonen, MUMC, Maastricht (chairman manuscript committee; thesis defence December 17,

2013) Dr. S. Koopmans, MUMC, Maastricht (thesis defence April 24, 2014) Dr. M. Rietbergen, VUmc, Amsterdam (thesis defence May 7, 2014) Dr. C. Bommelje, ErasmusUMC, Rotterdam (thesis defence July 8, 2015) Dr. H. van Monsjou, UvA/AvL/NKI, Amsterdam (thesis defence November 17, 2015) Dr. W.W. Mellema, VUmc, Amsterdam (thesis defence June 23, 2016) Dr. T. Brinkhuizen, MUMC, Maastricht (thesis defence June 24, 2016) Dr. V. van den Boogaart, MUMC Maastricht (chairman manuscript committee; thesis defence June

29, 2016) Dr. D. Maasland, MUMC, Maastricht (chairman manuscript committee; thesis defence October 5,

2016) Dr. C.T.D. Dickman, The University of British Columbia, Vancouver, Canada (thesis defence to be

determined in 2017) Drs. K. Cornel, MUMC Maastricht (thesis defence to be determined in 2018) Participation in thesis defence: Dr. B.J. Petri, Erasmus MC, Rotterdam (December 7, 2010) Dr. M. Lacko, MUMC, Maastricht (June 23, 2011) Dr. B. Jutten, MUMC, Maasricht (June 13, 2014) Dr. L. Poort, MUMC, Maastricht (December 10, 2015) Dr. F. Buishand, UU, Utrecht (January 5, 2016) Dr. K. Gerritsen, MUMC, Maastricht (May 27, 2016) Dr. C. Sauer, Klinikum Aachen, Germany (August 7, 2017) Dr. L. Ratz, MUMC, Maastricht (December 15, 2017) 14. List of publications Ernst-Jan Speel has published >200 scientific papers and book contributions between 1992 and February 2018. In February 2018 the number of papers annotated in PubMed was 157. On basis of these papers, which were cited over 4900 times during that period, his h-index is 39. A. Wi-1 [Impact Factor 2010] * = equal contribution as first author, # = equal contribution as last author Original research publications

1. Speel EJM, Schutte B, Ramaekers FCS, Hopman AHN: The effect of avidin-biotin inteactions in detection systems for in situ hybridization. J. Histochem. Cytochem. 40, 135-141, 1992 [2.381].

2. Speel EJM, Schutte B, Wiegant J, Ramaekers FCS, Hopman AHN: A novel fluorescence detection method for in situ hybridization, based on the alkaline phosphatase-Fast Red reaction. J. Histochem. Cytochem. 40, 1299-1308, 1992 [2.381].

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3. Speel EJM, Kamps M, Bonnet J, Ramaekers FCS, Hopman AHN: Multicolor preparations for in situ hybridization using precipitating enzyme cytochemistry in combination with reflection contrast microscopy. Histochemistry 100, 357-366, 1993 [4.727].

4. Speel EJM, Herbergs J, Ramaekers FCS, Hopman AHN: Combined immunocytochemistry and fluorescence in situ hybridization for simultaneous tricolor detection of cell cycle, genomic, and phenotypic parameters of tumor cells. J. Histochem. Cytochem. 42, 961-966, 1994 [2.381].

5. Speel EJM, Jansen MPHM, Ramaekers FCS, Hopman AHN: A novel triple-color detection procedure for brightfield microscopy, combining in situ hybridization with immunocytochemistry. J. Histochem. Cytochem. 42, 1299-1307, 1994 [2.381].

6. Speel EJM, Lawson D, Hopman AHN, Gosden J: Multi-PRINS: multiple sequential oligonucleotide primed in situ DNA synthesis reactions label specific chromosomes and produce bands. Hum. Genet. 95, 29-33, 1995 [5.047].

7. Martini E, Speel EJM, Geraedts JPM, Ramaekers FCS, Hopman AHN: Application of different in-situ hybridization detection methods for human sperm analysis. Hum. Reprod. 10, 855-861, 1995 [4.357].

8. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Rapid bright-field detection of oligonucleotide primed in situ (PRINS)-labeled DNA in chromosome preparations and frozen tissue sections. BioTechniques 20, 226-234, 1996 [2.550].

9. Herbergs J, Speel EJM, Ramaekers FCS, De Bruïne AP, Arends JW, Hopman AHN: Combination of lamin immunocytochemistry and in situ hybridization for the analysis of chromosome copy numbers in tumor cell areas with high nuclear density. Cytometry 23, 1-7, 1996 [3.753].

10. Speel EJM, Ramaekers FCS, Hopman AHN: Sensitive multicolor fluorescence in situ hybridization using catalyzed reporter deposition (CARD) amplification. J. Histochem. Cytochem. 45, 1439-1446, 1997 [2.381].

11. Hopman AHN, Claessen S, Speel EJM: Multi-colour brightfield in situ hybridisation on tissue sections. Histochem. Cell Biol. 108, 291-298, 1997 [4.727].

12. Hopman AHN, Ramaekers FCS, Speel EJM: Rapid synthesis of biotin-, digoxigenin-, trinitrophenyl-, and fluorochrome-labeled tyramides and their application for in situ hybridization using CARD-amplification. J. Histochem. Cytochem. 46, 771-777, 1998 [2.381].

13. Speel EJM, Van der Ven PFM, Albrechts JCM, Ramaekers FCS, Fürst DO, Hopman AHN: Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32. Genomics 54, 184-186, 1998 [3.327].

14. Slobbe-van Drunen MEP, Hendrickx ATM, Vossen RCRM, Speel EJM, Van Dam-Mieras MCE, Bruggeman CA: Nuclear import as a barrier to infection of human umbilical vein endothelial cells by human cytomegalovirus strain AD169. Virus Res. 56, 149-156, 1998 [2.905].

15. Speel EJM, Saremaslani P, Roth J, Heitz PU, Hopman AHN, Komminoth P: Improved mRNA in situ hybridization on formaldehyde-fixed, paraffin-embedded tissue using signal amplification with different haptenized tyramides. Histochem. Cell Biol. 110, 571-577, 1998 [4.727].

16. Perren A, Roth J, Muletta-Feurer S, Saremaslani P, Speel EJM, Heitz PU, Komminoth P. Clonal analysis of sporadic pancreatic endocrine tumours. J. Pathol. 186, 363-371, 1998 [7.274].

17. Görtz B, Roth J, Speel EJM, Krähenmann A, De Krijger RR, Mathias-Guiu X, Muletta-Feurer S, Rütimann K, Saremaslani P, Heitz PU, Komminoth P: MEN1 gene mutation analysis of sporadic adrenocortical lesions. Int. J. Cancer 80, 373-379, 1999 [4.926].

18. Van der Ven PFM, Speel EJM*, Albrechts JCM, Ramaekers FCS, Hopman AHN, Fürst DO: Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3. Genomics 55, 253-255, 1999 [3.327].

19. Görtz B, Roth J, Krähenmann, De Krijger RR, Muletta-Feurer S, Rütimann, Saremaslani P, Speel EJM, Heitz PU, Komminoth P: Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine (carcinoid) tumors and not restricted to foregut neoplasms. Am. J. Pathol. 154, 429-436, 1999 [5.224].

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20. Zhao J, Speel EJM, Muletta-Feurer S, Rütimann K, Saremaslani P, Roth J, Heitz PU, Komminoth P: Analysis of genomic alterations in sporadic adrenocortical lesions: gain of chromosome 17 is an early event in adrenocortical tumorigenesis. Am. J. Pathol. 155, 1039-1045, 1999 [5.224].

21. Volante M, Papotti M, Roth J, Saremaslani P, Speel EJM, Lloyd RV, Carney AJ, Heitz PU, Bussolati G, Komminoth P: Mixed medullary-follicular thyroid carcinoma: molecular evidence for a dual origin of tumor components. Am. J. Pathol. 155, 1499-1509, 1999 [5.224].

22. Speel EJM, Richter J, Moch H, Egenter C, Zhao J, Saremaslani P, Rütimann K, Barghorn A, Roth J, Heitz PU, Komminoth P: Genetic differences between sporadic endocrine pancreatic tumor subtypes detected by comparative genomic hybridization. Am. J. Pathol. 155, 1787-1794, 1999 [5.224].

23. Dannenberg H, Speel EJM*, Zhao J, Saremaslani P, Van der Harst E, Roth J, Heitz PU, Bonjer HJ, Dinjens WNM, Mooi WJ, Komminoth P, De Krijger RR: Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas. Am. J. Pathol. 157, 353-359, 2000 [5.224].

24. Zhao J, De Krijger RR, Meier D, Speel EJM, Saremaslani P, Muletta-Feurer S, Matter C, Roth J, Heitz PU, Komminoth P: Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (Carcinoids). Marked differences indicating diversity in molecular pathogenesis. Am J. Pathol. 157, 1431-1438, 2000 [5.224].

25. Bode-Lesniewska B, Zhao J, Speel EJM, Biraima AM, Turina M, Komminoth P, Heitz PU: Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery. Virchows Arch. 438:57-65, 2001 [2.336].

26. Labuhn M, Jones G, Speel EJM, Maier D, Zweifel C, Gratzl O, Van Meir EG, Hegi M, Merlo A: Quantitative real-time PCR does not show selective targeting of p14

ARF but

concomitant inactivation of both p16INK4a

and p14ARF

in 105 human primary gliomas. Oncogene 20, 1103-1109, 2001 [7.414].

27. Barghorn A, Speel EJM*, Farspour B, Saremaslani P, Schmid S, Perren A, Roth J, Heitz PU, Komminoth P: Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors. Am. J. Pathol. 158, 1903-1911, 2001 [5.224].

28. Dannenberg H, De Krijger RR, Zhao J, Speel EJM, Matter C, Saremaslani P, Dinjens WNM, Mooi WJ, Roth J, Heitz PU, Komminoth P: Differential loss of chromosome 11q in familial and sporadic parasympathetic paragangliomas detected by comparative genomic hybridization. Am. J. Pathol. 158, 1937-1942, 2001 [5.224].

29. Speel EJM, Scheidweiler AF, Zhao J, Matter C, Saremaslani P, Roth J, Heiz PU, Komminoth P: Genetic evidence for early divergence of small functioning and non-functioning endocrine pancreatic tumors: Gain of 9q34 is an early event in insulinomas. Cancer Res. 61, 5186-5192, 2001 [8.234].

30. Macville MVE, Van der Laak JAWM, Speel EJM, Katzir N, Garini Y, Soenksen D, McNamara G, De Wilde PCM, Hanselaar AGJM, Hopman AHN, Ried T: Spectral imaging of multi-color chromogenic dyes in pathological specimens. Anal. Cell. Pathol. 22, 133-142, 2001 [1.514].

31. Barghorn A, Komminoth P, Bachmann D, Rütimann K, Saremaslani P, Muletta-Feurer S, Roth J, Heitz PU, Speel EJM: Chromosome 3p alterations in endocrine pancreatic tumors: a common region of allelic loss at 3p23-p25 and association of 3p loss with advanced disease. J. Pathol. 194, 450-457, 2001 [7.274].

32. Zhao J, Moch H, Scheidweiler AF, Baer A, Schäffer AA, Speel EJM, Roth J, Heitz PU, Komminoth P: Genomic imbalances in the progression of endocrine pancreatic tumors. Genes Chromosomes Cancer 32, 364-372, 2001 [3.990].

33. Hopman AHN, Kamps MAF, Speel EJM, Schapers RFM, Sauter G, Ramaekers FCS: Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma in situ of the urinary bladder versus carcinoma in situ associated with carcinoma. Am. J. Pathol. 161, 1119-1125, 2002 [5.224].

34. Hafkamp HC, Speel EJM*, Haesevoets A, Bot FJ, Dinjens WNM, Ramaekers FCS, Hopman AHN, Manni JJ: A subset of head and neck squamous cell carcinomas exhibits

39

integration of HPV 16/18 DNA and overexpression of p16INK4A

and p53 in the absence of mutations in exons 5-8. Int. J. Cancer 107, 394-400, 2003 [4.926].

35. Wessels PH, Twijnstra A, Kubat B, Ummelen MIJ, Claessen S, Sciot R, Merlo A, Ramaekers FCS, Speel EJM, Hopman AHN: Chromosome 10q25.3 (DMBT1) and 10q12 copy number changes in astrocytoma grade II and IV. Genes Chromosomes Cancer 39, 22-28, 2004 [3.990].

36. Hopman AHN, Smedts F, Dignef W, Ummelen M, Sonke G, Mravunac M, Vooijs GP, Speel EJM, Ramaekers FCS: Transition of high grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J. Pathol. 202, 23-33, 2004 [7.274].

37. Hopman AHN, Kamps MAF, Smedts F, Speel EJM, Herrington CS, Ramaekers FCS: HPV in situ hybridization: the impact of different protocols on the detection of integrated HPV. Int. J. Cancer 115, 419-428, 2005 [4.926].

38. Jonkers YMH, Claessen SMH, Perren A, Schmid S, Komminoth P, Verhofstad AA, Hofland LJ, De Krijger RR, Slootweg PJ, Ramaekers FCS, Speel EJM: Chromosomal instability predicts metastatic disease in patients with insulinomas. Endocrine-related Cancer 12, 435-447, 2005 [4.432].

39. Aarts M, Dannenberg H, DeLeeuw RJ, Van Nederveen F, Verhofstad AA, Dinjens WNM, Speel EJM, Lam WL, De Krijger RR: Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb BAC array spanning chromosome arm 1p. Genes Chromosomes Cancer 45, 83-93, 2006 [3.990].

40. Van Koetsveld PM, Vitale G, De Herder WW, Feelders RA, Van der Wansem K, Waaijers M, Van Eijck CHJ, Speel EJM, Croze E, Van der Lely A-J, Lamberts SWJ, Hofland LJ. Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth. J Clin Endocrin Metab 91, 4537-4543, 2006 [6.495].

41. Jonkers YMH, Claessen SMH, Veltman JA, Geurts van Kessel A, Dinjens WNM, Skogseid B, Ramaekers FCS, Speel EJM. Molecular parameters associated with insulinoma progression: chromosomal instability versus p53 and CK19 status. Cytogenet Genome Res 115, 289-297, 2006 [1.783].

42. Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman JA, Speel EJM.

Novel candidate tumor suppressor gene loci on chromosomes 11q23-24

and 22q13 involved in human insulinoma tumorigenesis. J Pathol 210, 450-458, 2006 [7.274].

43. Hopman AHN, Theelen W, Hommelberg P, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Smedts F, Ramaekers FCS. Genomic integration of oncogenic HPV and gain of the Human Telomerase Gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. J Pathol 210, 412-419, 2006 [7.274].

44. Lucker G, Speel EJM*, Creytens D, Van Geest A, Peeters J, Claessen SMH, Vermeulen AHM, Pauwels P, Meulemans E.

Differences in Imiquimod treatment outcome in two

patients with Bowenoid Papulosis containing either episomal or integrated HPV 16. J Invest Dermatol 127, 727-729, 2007 (Epub Sep 28, 2006) [6.270].

45. Reimers N, Kasper HU, Weissenborn SJ, Stützer H, Preuss SF, Hoffmann TK, Speel EJM,

Dienes HP, Pfister HJ, Guntinas-Lichius O, Klussmann JP. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int J Cancer 120, 1731-1738, 2007 [4.926.

46. Vitale G, Van Eijck CHJ, Van Koetsveld PM, Erdmann JI, Speel EJM, Van der Wansem K, Mooij DM, Colao A, Lombardi G, Croze E, Lamberts SWJ, Hofland LJ. Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors. Ann Surg 246, 259-268, 2007 [7.474].

47. Smeets SJ, Hesselink AT, Speel EJM, Haesevoets A, De Vries J, Snijders PJF, Pawlita M, Meijer CJLM, Braakhuis BJ, Leemans CR, Brakenhoff RH. A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int J Cancer 121, 2465-2472, 2007 (Epub Aug 6, 2007) [4.926].

48. Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder W, De Krijger RR, Verhofstad AA, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM. DNA copy number status is a powerful predictor of survival

40

in endocrine pancreatic tumor patients. Endocrine-related Cancer 14, 769-779, 2007 [4.432].

49. De Krijger RR, Claessen SMH, Van der Ham F, Van Unnik AJM, Hulsbergen-Van de Kaa CM, Van Leuven L, Van Noesel M, Speel EJM. Gain of chromosome 8q is an early genetic event in pleuropulmonary blastomas. Modern Pathol 20, 1191-1199, 2007 (Epub Sept 14, 2007) [4.176].

50. Preuss SF, Weinell A, Molitor M, Stenner M, Semrau R, Drebber U, Weissenborn SJ, Speel EJM, Wittekindt C, Guntinas-Lichius O, Hoffmann TK, Eslick GD, Klussmann JP.

Nuclear survivin expression is associated with HPV-independent carcinogenesis and is a negative prognostic marker in oropharyngeal squamous cell carcinoma. Br J Cancer 98, 627-632, 2008 (Epub Jan 22, 2008) [4.831].

51. Petri B-J, Speel EJM*, Korpershoek E, Claessen SMH, Van Nederveen FM, Giesen V, Dannenberg H, Van der Harst E, Dinjens WNM, De Krijger RR. Comprehensive analysis of p53 aberrations in benign and malignant pheochromocytoma. Modern Pathol 21, 407-413, 2008 (Epub Jan 25, 2008) [4.176].

52. Hafkamp HC, Manni JJ, Haesevoets A, Voogd AC, Schepers M, Bot FJ, Hopman AHN, Ramaekers FCS, Speel EJM. Marked differences in survival rate between smokers and non-smokers with HPV 16-associated tonsillar carcinomas. Int J Cancer 122, 2656-2664, 2008 (Epub March 21, 2008) [4.926].

53. Speel EJM, Van de Wouw AJ, Claessen SMH, Haesevoets A, Hopman AHN, Van der Wurff AAM, Osieka R, Buettner R, Hillen HFP, Ramaekers FCS. Molecular evidence for a clonal relationship between multiple lesions in unknown primary tumor patients. Int J Cancer 123, 1292-1300, 2008 [4.926].

54. Bergshoeff VE, Hopman AHN, Zwijnenberg IR, Ramaekers FCS, Bot FJ, Kremer B, Manni JJ, Speel EJM. Letter to the editor. Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma. J Pathol 215, 347-348, 2008 (Epub April 17, 2008) [7.274].

55. Henopp T, Anlauf M, Schmitt A, Schlenger R, Zalatnai A, Couvelard A, Ruszniewski P, Schaps KP, Jonkers YM, Speel EJM, Pellegata NS, Heitz PU, Komminoth P, Perren A, Klöppel G. Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas. J Clin Endocrinol Metab 94, 213-217, 2009 (Epub Oct 28, 2008) [6.495].

56. Klussmann JP, Mooren JJ, Lehnen M, Claessen SM, Stenner M, Huebbers CU, Weissenborn SJ, Wedemeyer I, Preuss SF, Straetmans JM, Manni JJ, Hopman AH, Speel EJM. Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res 15, 1779-1786, 2009 (Epub Feb 17, 2009) [7.338].

57. Hafkamp HC, Mooren JJ, Claessen SHM, Klingenberg B, Voogd AC, Bot FJ, Klussmann

JP, Hopman AHN, Manni JJ, Kremer B, Ramaekers FCS, Speel EJM. P21Cip1/WAF1

expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Modern Pathol 22, 686-698, 2009 (Epub Mar 20, 2009) [4.176].

58. Straetmans JMJAA, Olthof N, Mooren JJ, De Jong J, Speel EJM#, Kremer B. Human papillomavirus reduces nodal involvement as prognostic indicator in tonsillar squamous cell carcinomas. Laryngoscope 119, 1951-1957, 2009 [2.096].

59. Theelen W, Reijans M, Simons G, Ramaekers FCS, Speel EJM, Hopman AHN. A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers. Int J Cancer 126, 959-975, 2010 (Epub Aug 25, 2009) [4.926].

60. Lopez JR, Claessen SMH, Macville MVE, Albrechts JCM, Skogseid B, Speel EJM.

Spectral karyotypic and comparative genomic analysis of the human endocrine pancreatic tumor cell line BON-1. Neuroendocrinology 91, 131-141, 2010 (Epub Oct 29, 2010) [3.272].

61. Klingenberg B, Hafkamp HC, Haesevoets A, Manni JJ, Slootweg PJ, Weissenborn SJ, Klussmann JP, Speel EJM.

p16

INK4A overexpression is frequently detected in tumor-free

tonsil tissue without association with HPV. Histopathology 56, 957-967, 2010 [3.569].

62. Fleskens S, Takes R, Otte-Höller I, Van Doesburg L, Smeets A, Speel EJM, Slootweg PJ, Van der Laak J. Simultaneous assessment of DNA ploidy and biomarker expression in paraffin-embedded tissue sections. Histopathology 57, 14-26, 2010 [3.569].

41

63. Theelen W, Speel EJM, Herfs M, Reijans M, Simons G, Ramaekers FCS, Somja J, Delvenne P, Hopman AHN. Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. Am J Pathol 177, 2022-2033, 2010 [5.224].

64. Stenner M, Yosef B, Huebbers CU, Preuss SF, Dienes HP, Speel EJM, Odenthal M, Klussmann JP. Nuclear translocation of β-catenin and decreased expression of E-cadherin in HPV-positive tonsilar cancer: An early event in HPV-related tumor progression? Histopathology 58, 1117-1126, 2011 [3.569].

65. Fleskens AJHM, Bergshoeff VE, Voogd AC, Van Velthuysen MLF, Bot FJ, Speel EJM, Kremer B, Takes RP, Slootweg PJ.

Interobserver variability of laryngeal mucosal

premalignant lesions: a histopathological evaluation. Modern Pathol 24, 892-898, 2011 [4.176].

66. Haugg AM, Speel EJM, Pantulu ND, Pallasch C, Kurz AK, Kvasnicka HM, Cathomas G, Wendtner C, Zur Hausen A. Fluorescence in situ hybridisation confirms the presence of Merkel Cell Polyoma Virus in chronic lymphocytic leukemia cells. Blood 117, 5776-5777, 2011 [10.558].

67. Huysentruyt CJR, Baldewijns MM, Meulemans EV, Rüland AM, Tonk RJW, Vervoort PSAM, Smits KM, Van de Beek C, Speel EJM. Modified UroVysion scoring criteria increase the detection rate of urothelial cell carcinoma in patients with equivocal urinary cytology. Histopathology 58, 1048-1053, 2011 [3.569].

68. Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AC, De Herder WW, De Krijger RR, Smit EF, Thunnissen FBJM, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS, Speel EJM. Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and a poor clinical outcome. Am J Pathol 179, 1129-1137, 2011 [5.224].

69. Farshadpour, Konings S, Speel EJM, Hordijk GJ, Koole R, Slootweg PJ, Kummer JA. Human papillomavirus and oropharyngeal cancer: a case-control study regarding tobacco and alcohol usage. Pathol Res Int 2011, 2011:806345 (Epub July 12, 2011).

70. Van Hooff SR, Leusink FKJ, Roepman P, Baatenburg de Jong RP, Speel EJM, Van den Brekel MMW, Van Velthuysen ML, Van Diest PJ, van Es RJ, Merkx MAW, Kummer JA, Leemans CR, Schuuring EMD, Langendijk JA, Lacko M, De Herdt MJ, Jansen JC, Brakenhoff RH, Slootweg PJ, Takes RP, Holstege FCP: Validation of a gene expression signature for assssment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol 30, 4104-4110, 2012 [18.970].

71. Straetmans JMJAA, Speel EJM, Kremer B. Letter to the editor. Value of human papillomavirus testing in the diagnostic workup of lymph node metastases from an unknown primary tumor of the neck. Head Neck 34, 1819-1820, 2012 [2.182].

72. Mooren JJ, Kremer B, Claessen SMH, Voogd AC, Bot FJ, Klussmann JP, Huebbers CU, Hopman AHN, Ramaekers FCS, Speel EJM: Chromosome stability in tonsillar squamous cell carcinomas is associated with HPV 16 integration and indicates a favourable prognosis. Int J Cancer 132, 1781-1789, 2013 [4.926].

73. Buisband FO, Kirpensteijn J, Jaarsma AA, Speel EJM, Kik M, Mol JA: Gene expression profiling of primary canine insulinomas and their metastases. Vet J 197, 192-197, 2013 [2.796].

74. Huebbers CU, Preuss SF, Kolligs J, Vent J, Stenner M, Wieland U, Silling S, Drebber U, Speel EJM#, Klussman JP: Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile onset laryngeal papillomatosis. PloS One 2013, 8(2): e57207. doi: 10.1371/journal.pone.0057207 (Epub Feb 20 [4.411].

75. Swarts DRA, Henfling ME, Van Neste L, Van Suylen RJ, Dingemans AM, Dinjens WNM, Haesevoets A, Rudelius M, Thunnissen E, Volante M, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: CD44 and OTP are strong prognostic markers for pulmonary carcinoids. Clin Cancer Res 19, 2197-2207, 2013 [7.338].

76. Van Koetsveld PM, Vitale G, Feelders RA, Waaijers MM, Sprij-Mooij DM, De Krijger RR, Speel EJM, Hofland J, Lamberts SWJ, De Herder WW, Hofland LJ: Interferon-ß is a potent

42

inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane. Endocr Relat Cancer 20, 443-454, 2013 [4.432].

77. Zur Hausen A, Rennspiess D, Winnepenninckx V, Speel EJM, Kurz AK: Early B-cell differentiation in Merkel cell carcinomas: clues to cellular ancestry. Cancer Res 73, 4982-4987, 2013 [9.284].

78. Litjens JNTM, Theelen W, Van de Pas Y, Ossel J, Reijans M, Simons G, Speel EJM, Slangen BFM, Ramaekers FCS, Kruitwagen RFPM, Hopman AHN: Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions. J Med Virol 85, 1386-1393, 2013 [2.217].

79. Swarts DRA, Van Neste L, Henfling ME, Eijkenboom I, Eijk PP, Van Velthuysen ML, Vink A,

Volante M, Ylstra B, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: An exploration of pathways involved in lung carcinoid progression using gene expression profiling. Carcinogenesis 34, 2726-2737, 2013 [5.266].

80. Sørensen BS, Busk M, Olthof NC, Speel EJM, Horsman MR, Alsner J, Overgaard J: Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells. Radiother Oncol 108, 500-505, 2013 [4.857].

81. Theelen W, Litjens JNTM, Vinokurova S, Haesevoets A, Reijans M, Simons G, Smedts F, Herrington CS, Ramaekers FCS, Von Knebel Doeberitz M, Speel EJM, Hopman AHN: Human papillomavirus multiplexligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies. Human Pathol 44, 2410-2418, 2013 [2.806].

82. Siebers TJ, Bergshoeff VE, Otte-Höller I, Kremer B, Speel EJM, Van der Laak JA, Merkx MAW, Slootweg PJ: Chromosome instability predicts the progression of premalignant oral lesions. Oral Oncol 49, 1121-1128, 2013 [3.029].

83. Sturm B, Fleskens SJ, Bot FJ, van Velthuysen ML, Speel EJM, Slootweg PJ, van der Laak JAWM: Virtual microscopy is a valid alternative for the diagnostic assessment of laryngeal premalignancies. Histopathology 64, 602-604, 2014 [3.301].

84. Mooren JJ, Gültekin SE, Straetmans JMJAA, Haesevoets A, Peutz-Kootstra CJ, Huebbers CU, Dienes HP, Wieland U, Ramaekers FCS, Kremer B, Speel EJM#, Klussmann JP: P16

INK4A immunostaining is a strong indicator for high-risk HPV-associated oropharyngeal

carcinomas and dysplasias, but is unreliable to predict low-risk HPV infection in head and neck papillomas and laryngeal dysplasias. Int J Cancer 134, 2108-2117, 2014 [5.007].

85. Marinoni I, Kurrer AS, Vassella E, Dettmer M, Rudolph T, Banz V, Hunger F, Pasquinelli S, Speel EJM, Perren A: Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors. Gastroenterology 146, 453-460, 2014 [13.926].

86. Swarts DRA, ScarpaA, Corbo V, Van Criekinge W, Van Engeland M,

Gatti G, Henfling ME,

Papotti M, Perren A, Ramaekers FCS, Speel EJM#, Volante M: MEN1 gene mutation and

reduced expression are associated with poor prognosis in pulmonary carcinoids. J Clin Endocr Metab 99, E374-378, 2014 [6.310].

87. Litjens JNTM, Van de Vijver KK, Hopman AHN, Ummelen MI, Speel EJM, Sastrowijoto SH, Van Gorp T, Slangen BFM, Kruitwagen RFPM, Krüse AJ: The majority of metachronous CIN1 and CIN3 lesions are caused by different human papillomavirus genotypes, indicating that th pesence of CIN1 seems not to determine the risk for subsequent detection of CIN3. Human Pathol 45, 221-226, 2014 [2.806].

88. Creytens D, van Gorp J, Ferdinande L, Speel EJM, Libbrecht L: Detection of CDK4/MDM2 amplification in lipomatous soft tissue tumors from formalin-fixed, paraffin-embedded tissue: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH). Diagn Mol Pathol 2014, in press (Epub Jan 30) [2.275].

89. Hendriks LE, Smit EF, Vosse BA, Mellema WW, Heideman DA, Bootsma GP, Westenend M, Pitz C, de Vries GJ, Houben R, Grünberg K, Bendek M, Speel EJM, Dingemans AM: EGFR mutated non small cell lung cancer patients: more prone to development of bone and brain metastases? Lung Cancer 84, 86-91, 2014 [3.737].

43

90. Olthof NC, Speel EJM#, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Drebber U, Wieland U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU: Comprehensive analysis of HPV 16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS One 2014, 9(2):e88718. doi: 10.1371/journal.pone.0088718 [3.534].

91. Bergshoeff VE, Van der Heijden SJ, Haesevoets A, Litjens SGH, Bot FJ, Voogd AC, Chenault MN, Hopman AHN, Schuuring EMD, Van der Wal JE, Manni JJ, Ramaekers FCS, Kremer B, Speel EJM: Chromosome instability predicts progression of premalignant lesions of the larynx. Pathology 46, 216-224, 2014 [2.620].

92. Haugg AM, Rennspiess D, Zur Hausen A, Speel EJM, Cathomas G, Becker JC, Schrama D: Fluorescence in situ hybridisation and qPCR to detect Merkel Cell polyomavirus physical status and load in Merkel cell carcinomas. Int J Cancer 135, 2804-2815, 2014 [5.007].

93. Swarts DRA, Van Suylen RJ, Den Bakker M, Van Oosterhout MFM, Thunnissen FBJM, Volante M, Dingemans AM, Scheltinga M, Bootsma G, Pouwels HMM, Van der Borne B, Ramaekers FCS, Speel EJM: Interobserver variability for the WHO classification of pulmonary carcinoids. Am J Surg Pathol 38, 1429-1436, 2014 [5,145].

94. Blackhall FH, Peters S, Bubendorf L, Dafni U, Kerr KM, Hager H, Soltermann A, O'Byrne KJ, Dooms C, Sejda A, Hernández-Losa J, Marchetti A, Savic S, Tan Q, Thunnissen E, Speel EJM, Cheney R, Nonaka D, de Jong J, Martorell M, Letovanec I, Rosell R, Stahel RA: Prevalence and clinical outcomes for patients with ALK-positive resected stage I-III adenocarcinoma: Results from the European Thoracic Oncology Platform Lungscape Project. J Clin Oncol 32, 2780-2787, 2014 [18,443].

95. De Ruyck K, Duprez F, Ferdinande L, Mbah C, Rios-Velazquez E, Hoebers F, Praet M, Deron P, Bonte K, Speel EJM, Libbrecht L, De Neve W, Lambin P, Thierens H: A let-7 microRNA polymorphism in the KRAS 3'-UTR is prognostic in oropharyngeal cancer. Cancer Epidemiol 38, 591-598, 2014 [2,711].

96. Peters S, Weder W, Dafni U, Kerr KM, Bubendorf L, Meldgaard P, O'Byrne KJ, Wrona A, Vansteenkiste J, Felip E, Marchetti A, Savic S, Lu S, Smit E, Dingemans AM, Blackhall FH, Baas P, Camps C, Rosell R, Stahel RA; ETOP Lungscape Investigators (including Speel EJM). Lungscape: resected non-small-cell lung cancer outcome by clinical and pathological parameters. J Thorac Oncol 9, 1675-1684, 2014 [5,282].

97. Rios Velazquez E, Hoebers F, Aerts HJWL, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJM, Straetmans JMJAA, Kremer B, Lambin P: Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging. Radiother Oncol 113, 324-330, 2014 [4,363].

98. Straetmans JMJAA, Vent J, Lacko M, Speel EJM, Huebbers CU, Semrau R, Hoebers F, Mujagic Z, Klussmann JP, Preuss S, Kremer B: Management of neck metastases of unknown primary origin united in two European centers. Eur Arch Otorhinolaryngol 272, 195-205, 2015 [1,545].

99. Rennspiess D, Pujari S, Keijzers M, Abdul-Hamid MA, Hochstenbag M, Dingemans AM, Kurz AK, Speel EJM, Haugg A, Buck CB, De Baets MH, Zur Hausen A:

Detection of

Human Polyomavirus 7 in human thymic epithelial tumors. J Thorac Oncol 10, 360-366, 2015 [5,282].

100. Creytens D, van Gorp J, Ferdinande L, Speel EJM, Libbrecht L: Detection of MDM2/CDK4 amplification in lipomatous soft tissue tumors from formalin-fixed, paraffin-embedded tissue: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH). Appl Immunohistochem Mol Morphol 23, 126-133, 2015 [2,012].

101. Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, van Lent-Albrechts JA, Stegmann AP, Silling S, Wieland U, Carey TE, Walline HM, Gollin SM, Hoffmann TK, de Winter J, Kremer B, Klussmann JP, Speel EJM: Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines. Int J Cancer 136, E207-E218, 2015 [5.085].

44

102. Verlinden I, Van den Hurk K, Clarijs R, Willig AP, Stallinga C, Roemen GMJM, Van den Oord JJ, Zur Hausen A, Speel EJM

#, Winnepenninckx VJL: BRAF

V600E immuno positive

melanomas show low frequency of heterogeneity and association with epithelioid tumor cells-a STROBE compliant article. Medicine 2014 Dec;93(28):e285. doi: 10.1097/MD.0000000000000285. Erratum in: Medicine 2015 Apr;94(14):DOI: 10.1097/01.md.0000464339.19779.8f [5,723].

103. Reuschenbach M, Huebbers CU, Prigge ES, Bermejo JL, Kalteis MS, Preuss SF, Seuthe IM, Kolligs J, Speel EJM, Olthof N, Kremer B, Wagner S, Klussmann JP, Vinokurova S, von Knebel Doeberitz M: Methylation status of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers. Cancer 121, 1966-1976, 2015 [5,068].

104. Rapa I, Votta A, Felice B, Righi L, Giorcelli J, Scarpa A, Speel EJM, Scagliotti GV, Papotti M, Volante M: Identification of MicroRNAs Differentially Expressed in Lung Carcinoid Subtypes and Progression. Neuroendocrinology 101, 246-255, 2015 [4,373].

105. Prickaerts P, Niessen HE, Dahlmans VE, Spaapen F, Salvaing J, Vanhove J, Geijselaers C, Bartels SJ, Partouns I, Neumann D, Speel EJM, Takihara Y, Wouters BG, Voncken JW: MK3 modulation affects BMI1-dependent and independent cell cycle check-points. PLoS One 10, e0118840, 2015 [3,234].

106. Creytens D, Van Gorp J, Speel EJM, Ferdinande L. Characterization of the 12q amplicons in lipomatous soft tissue tumors by multiplex ligation-dependent probe amplification-based copy number analysis.Anticancer Res 35, 1835-1842, 2015 [1,826].

107. Melchers LJ, Mastik MF, Samaniego Cameron B, van Dijk BA, de Bock GH, van der Laan BF, van der Vegt B, Speel EJM, Roodenburg JL, Witjes MJ, Schuuring E: Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye. Br J Cancer 112, 1349-1357, 2015 [4,836].

108. Rietbergen MM, Witte BI, Velazquez ER, Snijders PJ, Bloemena E, Speel EJM, Brakenhoff RH, Kremer B, Lambin P, Leemans CR: Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe. Br J Cancer 112, 1733-1736, 2015 [4,836].

109. Kuiper JL, Hendriks LE, van der Wekken AJ, de Langen AJ, Bahce I, Thunnissen E, Heideman DA, Berk Y, Buijs EJ, Speel EJM, Krouwels FH, Smit HJ, Groen HJ, Dingemans AM, Smit EF: Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: A retrospective cohort analysis. Lung Cancer 89, 255-261, 2015 [3,958].

110. Jóri B, Kamps R, Xanthoulea S, Delvoux B, Blok MJ, Van de Vijver KK, de Koning B, Trups Oei F, Tops CM, Speel EJM, Kruitwagen RF, Gomez-Garcia EB, Romano A: Germ-line variants identified by next generation sequencing in a panel of estrogen and cancer associated genes correlate with poor clinical outcome in Lynch syndrome patients. Oncotarget 6, 41108-41122, 2015 [6,359].

111. Derks JL, Hendriks LE, Buikhuisen WA, Groen HJ, Thunnissen E, van Suylen RJ, Houben R, Damhuis RA, Speel EJM, Dingemans AC: Clinical features of large cell neuroendocrine carcinoma: a population-based overview. Eur Respir J 47, 615-624, 2016 [7,636].

112. Derks JL, Speel EJM, Dingemans AC: An unmet need in the WHO 2015 biopsy classification: poorly differentiated non-small cell lung carcinomas with positive neuroendocrine markers. Letter to the Editor. J Thorac Oncol 11, e35-e38, 2016 [5,282].

113. Derks JL, Speel EJM, Thunnissen E, van Suylen RJ, Buikhuisen WA, van Velthuysen ML, Dingemans AMC: Neuro-endocrine cancer of the lung: a diagnostic puzzle. J Thorac Oncol 11, 593-602, 2016 [5,282].

114. Derks JL, van Suylen RJ, Thunnissen E, den Bakker MA, Smit EF, Groen HJM, Speel EJM#, Dingemans AMC: A population based analysis on application of WHO-nomenclature in pathology reports of pulmonary neuroendocrine tumors. J Thorac Oncol 11, 593-602, 2016 [5,282].

115. Hillen LM, Kamsteeg EJ, Schoots J, Tiebosch A, Speel EJM, Roemen GM, Peutz-Koostra CJ, Stumpel CTRM: Refining the diagnosis of congenital nephrotic syndrome on long-term

45

stored tissue: c.1097G>A (p.(Arg366His)) WT1 mutation causing Denys Drash Syndrome. Fetal Pediatric Pathol 35, 112-119, 2016.

116. O’Sullivan B, Huang SH, Su J, Garden A, Sturgis E, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman S, Adelstein D, Burkey BB, Friborg J, Kristensen C, Gothelf A, Hoebers F, Kremer B, Speel EJM, Raben D, Bowles D, Karam S, Yu E, Xu W: Clinical Staging Proposal for HPV-related Oropharyngeal Cancer: The International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S) Study. Lancet Oncol 17, 440-451, 2016 [24,690].

117. Buishand FO, Arkesteijn GJ, Feenstra L, Oorsprong C, Mestemaker M, Starke A, Speel EJM, Kirpensteijn J, Mol J: Identification of CD90 as a putative cancer stem cell marker and therapeutic target in insulinomas. Stem Cells Dev 25, 826-835, 2016.

118. Beckervordersandforth J, Pujari S, Rennspiess D, Speel EJM, Winnepenninckx V, Diaz C, Weyers W, Haugg AM, Kurz AK, Zur Hausen A: Frequent detection of human polyomavirus 6 in keratoacanthomas. Diagn Pathol 11, 58, 2016.

119. Reinders MGHC, Boersma HJ, Leter EM, Vreeburg M, Paulussen ADC, Arits AHMM,

Roemen GMJM, Speel EJM, Steijlen PM, van Geel M, Mosterd K: Postzygotic mosaicism in basal cell naevus syndrome. Br J Dermatol 177, 249-252, 2017..

120. Swarts DRA, Rudelius M, Claessen SMH, Cleutjens JP, Seidl S, Volante M, Ramaekers FCS, Speel EJM: Limited additive value of Ki-67 proliferative index on patient survival in WHO classified pulmonary carcinoids. Histopathology 70, 412-422, 2017.

121. van Loon J, Even AJ, Aerts HJ, Öllers M, Hoebers F, van Elmpt W, Dubois L, Dingemans AC, Lalisang RI, Kempers P, Brans B, Winnepenninckx V, Speel EJM, Thunnissen E, Smits KM, Boellaard R, Vugts DJ, De Ruysscher D, Lambin P. PET imaging of zirconium-89 labelled cetuximab: A phase I trial in patients with head and neck and lung cancer. Radiother Oncol 122, 267-273, 2017.

122. Van der Wekken AJ, Pelgrim R, ’t Hart N, Werner N, Mastik MF, Hendriks L, Van der Heijden EHFM, Looijen-Salamon M, De Langen AJ, Staal-van den Brekel J, Riemersma S, Van de Borne BEEM, Thunnissen E, Speel EJM, Dingemans AMC, Hiltermann TJN, Van den Berg A, Timens W, Schuuring E, Groen HJM: Dichotomous ALK-IHC is a better predictor for ALK inhibition outcome than traditional ALK-FISH in advanced non-small cell lung cancer. Clin Cancer Res 23, 4251-4258, 2017.

123. Pierssens DDCG, Borgemeester MC, Van der Heijden SJ, Peutz-Kootstra CJ, Ruland AM, Haesevoets AM, Kessler P, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence. Oral Oncol 66, 14-21, 2017.

124. Derks JL, van Suylen RJ, Thunnissen E, den Bakker MA, Groen HJ, Smit EF, Damhuis RA, van den Broek EC, Speel EJM#, Dingemans AC; PALGA group. Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter? Eur Respir J. 49(6), 1601838, 2017

125. Velazquez ER, Hoebers F, Aerts HJWL, Rietbergen MM, Brakenhoff RH, Leemans RC, Speel EJM, Straetmans J, Kremer B, Lambin P. Corrigendum to "Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging" [Radiother Oncol 113 (2014) 324-30]. Radiother Oncol. 124, 337-338, 2017.

126. Bubendorf L, Dafni U, Schöbel M, Finn SP, Tischler V, Sejda A, Marchetti A, Thunnissen E, Verbeken EK, Warth A, Sansano I, Cheney R, Speel EJM, Nonaka D, Monkhorst K, Hager H, Martorell M, Savic S, Kerr KM, Tan Q, Tsourti Z, Geiger TR, Kammler R, Schulze K, Das-Gupta A, Shames D, Peters S, Stahel RA; Lungscape Consortium. Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project. Lung Cancer 111, 143-149, 2017

127. Ilmarinen T, Munne P, Hagström J, Haglund C, Auvinen E, Virtanen EI, Haesevoets A, Speel EJM, Aaltonen LM: Prevalence of high-risk human papillomavirus infection and cancer gene mutations in nonmalignant tonsils. Oral Oncol 73, 77-82, 2017

46

128. Female urothelial cell carcinoma in a failed kidney graft of a male recipient: de Jongh HJJ, van Duijnhoven EM, Rüland A, Abdul Hamid MMA, Speel EJM, van de Beek K. Neth J Med 75, 354-356, 2017.

129. Derks J, van Suylen RJ, Thunnissen E, den Bakker M, Groen H, Smit E, Damhuis R, van den Broek E, Speel EJM#, Dingemans AC: Why we should improve current practice of diagnosing and treating pulmonary large cell neuroendocrine carcinomas in patients with advanced disease. Eur Respir J 50, 1701658, 2017

130. Derks JL, Leblay N, Thunnissen E, van Suylen RJ, den Bakker M, Groen HJM, Smit EF, Damhuis R, van den Broek EC, Charbrier A, Foll M, McKay JD, Fernandez-Cuesta L, Speel EJM#, Dingemans AC; PALGA-Group: Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. Clin Cancer Res. 24, 33-42, 2018.

131. Kerr KM, Dafni U, Schulze K, Thunnissen E, Bubendorf L, Hager H, Finn S, Biernat W, Vliegen L, Losa JH, Marchetti A, Cheney R, Warth A, Speel EJM, Blackhall F, Monkhorst K, Jantus Lewintre E, Tischler V, Clark C, Bertran-Alamillo J, Meldgaard P, Gately K, Wrona A, Vandenberghe P, Felip E, De Luca G, Savic S, Muley T, Smit EF, Dingemans AC, Priest L, Baas P, Camps C, Weder W, Polydoropoulou V, Geiger TR, Kammler R, Sumiyoshi T, Molina MA, Shames DS, Stahel RA, Peters S; ETOP Lungscape Consortium. Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: results from the ETOP Lungscape Project. Ann Oncol 29, 200-208, 2018.

132. Yakkioui Y, Speel EJM, Van Overbeeke JJ, Boderie MJM, Pujari S, Hausen AZ, Wolffs PFG, Temel Y: Oncogenic viruses in Skull Base Chordomas. World Neurosurg. 2018, in press (Epub Nov 27, 2017).

133. Letovanec I, Finn S, Zygoura P, Smyth P, Soltermann A, Bubendorf L, Speel EJM, Marchetti A, Nonaka D, Monkhorst K, Hager H, Martorell M, Sejda A, Cheney R, Hernandez-Losa J, Verbeken E, Weder W, Savic S, Di Lorito A, Navarro A, Felip E, Warth A, Baas P, Meldgaard P, Blackhall F, Dingemans AM, Dienemann H, Dziadziuszko R, Vansteenkiste J, O'Brien C, Geiger T, Sherlock J, Schageman J, Dafni U, Kammler R, Kerr K, Thunnissen E, Stahel R, Peters S; European Thoracic Oncology Platform Lungscape Consortium: Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project. J Thorac Oncol 2018, in press (Epub Nov 27, 2017)

134. Hillen LM, Rennspiess D, Speel EJM, Haugg AM, Winnepenninckx V, Zur Hausen A: Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis. Front Microbiol 8, 2648, 2018.

135. Sinx KAE, Roemen G, van Zutphen V, Janssen R, Speel EJM, Steijlen PM, van Geel M, Mosterd K: Vismodegib resistant basal cell carcinomas in Gorlin syndrome, clinical approach and genetic analysis. J Am Acad Dermatol 2018, in press.

Submitted for publication/under revision:

136. Würdemann N, Gültekin SE, Wittekindt C, Sharma SJ,

Schubotz AB, Gattenlöhner S,

Tharun L, Baris E, Sengüven B, Yildirim B, Speel EJM, Wagner S, Klussmann JP, Quaas

A: PD-L1 but not PD-L2 Expression is Associated with Improved Survival in HPV-related and -unrelated Oropharyngeal Squamous Cell Carcinoma. Int J Cancer, under revision.

137. Henfling MER, Perren AA, Schmitt AM, Saddig CM, Starke AA, Riedl RG, Versleijen-Jonkers YMH, Sprij-Mooij DM, Ramaekers FCS, Hofland LJ, Speel EJM: The IGF pathway is activated in Pancreatic NETs but downregulated in metastatic disease. ERC 2018, under revision.

138. Huebbers CU, Verhees F, Poluschkin L, Olthof NC, Kolligs J, Siefer OG, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Seehawer J, Drebber U, Lam WL, Vucic EA, Kremer B, Klussmann JP, Speel EJM: Upregulation of AKR1C1 and AKR1C3 expression

47

in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.

139. Bergshoeff VE, Balkenhol MCA, Haesevoets A, Ruland A, Chenault MN, Nelissen RC, Peutz CJ, Nap M, Van der Laak JAWM, Slootweg PJ, Takes RP, Van den Brekel MW, Van Velthuysen MF, Ramaekers FCS,

Kremer B, Speel EJM: Evaluation criteria for

chromosome instability detection by FISH to predict malignant progression in premalignant glottic laryngeal lesions.

140. Chteinberg zur Hausen REST

141. Chteinberg zur Hausen PIK3CA

142. Hartgerink DEJ, Mosterd K, Postma AA, Lalisang R, Speel EJM, Hoeben A: Durable response of a recurrent, irresectable, locally advanced Squamous Cell Carcinoma of the Skin with microsattelite intability treated with immunotherapy.

143. Straetmans JMJAA, Stuut M, Wagemakers S, Hoebers F, Kaanders JAHM, Speel EJM, Melchers W, Slootweg P, Kremer B, Lacko M, Takes RP: Cervical lymph node metastases of unknown primary tumors: impact of ipsilateral vs. bilateral radiotherapy.

144. Bulthuis VJ, Damen PJJ, Hanssens PEJ, Lie ST, Fleischeuer R, Melotte V, Wouters K, Ruland A, Beckervordersandforth J, Speel EJM, van Overbeeke JJ: 1p36 Loss Is Associated with Regrowth of WHO Grade I Meningiomas after Gamma Knife Radiosurgery.

145. Pramana J, Mooren JJ, De Jong M, Van den Brekel MWM, Van Velthuysen ML, Kremer B, Begg AC, Speel EJM: EGFR expression predicts unfavorable survival in advanced HPV-positive oropharyngeal cancer treated with chemoradiation In preparation

146. Straetmans JMJAA, Stuut M, Hoebers F, Lacko M, Speel EJM, Kremer B: Human papilloma virus confuses the prognostic value of UICC’s TNM classification in tonsillar squamous cell carcinomas.

147. Fleskens AJHM, Bergshoeff VE, van der Laak JAWM, Otte-Höller I, Saksens N, Speel EJM, Kremer B, Takes RP, Slootweg PJ: Simultaneous assessment of biomarkers predicts malignant potential of laryngeal mucosal lesions.

148. Verhees F, Jacobs R, Cornet I, Kremer B, Speel EJM: Efficacy of the antiviral agent Cidofovir to inhibit the growth of HPV-positive and -negative head and neck squamous cell carcinomas in vitro.

149. Koster J et al. NDRG4 expression lung cancer.

150. Petri BJ, De Krijger RR, Van Nederveen FH, Claessen SHM, Dannenberg H, Verhofstad AA, Dinjens WNM, Speel EJM. Genomic analysis of pheochromocytomas: identification of specific DNA copy number changes but exclusion of 6q loss in association with biological behavior.

151. De Rozario L, Bergshoeff VE, De Jong JMA, Speel EJM, Van den Ende PLA, Kremer B. Laryngeal carcinoma in situ: population-based results of laser surgery and radiotherapy.

152. Creytens D, Rüland AM, Geskes G, Pauwels P, Speel EJM. Inflammatory variant of a well-differentiated liposarcoma of the mediastinum exhibiting MDM2/CDK4 gene amplification: a case report and review of literature.

153. Paper Koen vd Vijver

154. Paper Jorn Heerink meningeomas Reviews

1. Speel EJM, Ramaekers FCS, Hopman AHN: Detection systems for in situ hybridization, and the combination with immunocytochemistry. `Who is still afraid of red, green and blue?' Histochem J 27, 833-858, 1995 [2.239].

2. Speel EJM, Hopman AHN, Komminoth P: Amplification methods to increase the sensitivity of in situ hybridization: play CARD(s). J Histochem Cytochem 47, 281-288, 1999 [2.381].

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3. Speel EJM, Komminoth P: CARD in situ hybridization: sights and signals. Endocrine Pathol 10, 193-198, 1999 [1.568].

4. Speel EJM: Detection and amplification systems for sensitive, multiple-target DNA and RNA in situ hybridization: looking inside cells with a spectrum of colors. Histochem Cell Biol 112, 89-113, 1999 [4.727].

5. Van de Wouw Y, Jansen RLH, Speel EJM, Hillen HFP: The unknown biology of the unknown primary tumor: a literature review. Ann Oncol 14, 191-196, 2003 [6.452].

6. Dannenberg H, Komminoth P, Dinjens WM, Speel EJM, De Krijger RR: Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas. Endocrine Pathol 14, 329-350, 2003 [1.568].

7. Hafkamp HC, Manni JJ, Speel EJM: Role of human papillomavirus in the development of head and neck squamous cell carcinomas. Acta Otolaryngol 124, 520-526, 2004 [1.200].

8. Klussmann JP, Dinh S, Wittekindt C, Weissenborn S, Wieland U, Dienes HP, Hoffmann T, Smith E, Haugen T, Turek L, Speel EJM, Pfister HJ: HPV associated tonsillar carcinomas: an update. HNO 52, 208-218, 2004 [0.543].

9. Jonkers YMH, Ramaekers FCS, Speel EJM: Molecular alterations during insulinoma tumorigenesis. BBA Reviews in Cancer 1775, 313-332, 2007 [9.886].

10. Klussmann JP, Preuss SF, Speel EJM: Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications. HNO 57, 113-122, 2009 [0.543].

11. Olthof NC, Straetmans JMJAA, Snoeck R, Ramaekers FCS, Kremer B, Speel EJM: Next generation treatment strategies for HPV-related head and neck squamous cell carcinomas: where do we go? Rev Med Virol 22, 88-105, 2012 [5.600].

12. Swarts DRA, Ramaekers FCS, Speel EJM: Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. BBA Reviews in Cancer 1826, 255-271, 2012 [9.886].

13. Dreijerink KM, Derks JL, Cataldo I, Scarpa A, Valk GD, Speel EJM: Genetics and epigenetics of pancreatic neuroendocrine tumors and pulmonary carcinoids. Front Horm Res 44, 115-138, 2015 [3.304].

14. Swarts DRA, Ramaekers FCS, Speel EJM: Gene expression profiling of pulmonary neuroendocrine neoplasms: a comprehensive overview. Cancer Treatm Comm 4, 148-160, 2015.

15. Sauer CM, Haugg AM, Chteinberg E, Rennspiess D, Winnepenninckx V, Speel EJM, Becker JC, Kurz AK, Zur Hausen A: Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma. Crit Rev Oncol Hematol 116, 99-105, 2017.

16. Vaassen LAA, Speel EJM, Kessler PAWH. Bone invasion by oral squamous cell carcinoma: Molecular alterations leading to osteoclastogenesis - a review of literature. J Craniomaxillofac Surg 45, 1464-1471, 2017.

17. Derks JL, Leblay N, Lantuejoul S, Dingemans AM, Speel EJM#, Fernandez-Cuesta L: New insights into the molecular characteristics of pulmonary carcinoids and large-cell neuroendocrine carcinomas, and impact on clinical management. J Thorac Oncol 2018, in press.

E. WB/WBC Book chapters

1. Hopman AHN, Speel EJM, Voorter CEM, Ramaekers FCS: Probe labelling methods. In: Non-isotopic methods in molecular biology: a practical approach. Eds Levy ER, Herrington CS. IRL Press, Oxford University Press, Oxford, 1995, pp. 1-24.

2. Speel EJM, Lawson D, Ramaekers FCS, Gosden J, Hopman AHN: Brightfield microscopical detection of oligonucleotide primed in situ (PRINS) labelled DNA in chromosome preparations. In: Methods in Molecular Biology, Vol. XX: Protocols for PRINS and in situ PCR. Ed: Gosden J. Humana Press Inc, Totowa, NJ, USA, 1997, pp. 13-22.

3. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Primed in situ (PRINS) DNA synthesis on frozen tissue sections. In: Methods in Molecular Biology, Vol. XX: Protocols

49

for PRINS and in situ PCR. Ed: Gosden J. Humana Press Inc, Totowa, NJ, USA, 1997, pp. 31-37.

4. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Combined immunocytochemistry and primed in situ (PRINS) DNA synthesis for simultaneous detection of phenotypic and genomic parameters in cells. In: Methods in Molecular Biology, Vol. XX: Protocols for PRINS and in situ PCR. Ed: Gosden J. Humana Press Inc, Totowa, NJ, USA, 1997, pp. 53-60.

5. Hopman AHN, Voorter CEM, Speel EJM, Ramaekers FCS (1997) In situ hybridization and comparative genomic hybridization. In Wolman SR, Sell S (eds): Cytogenetic cancer markers. Humana Press Inc., Totowa, NJ, pp. 45-69.

6. Gosden JR, Speel EJM, Shibasaki Y: Primed in situ DNA synthesis (PRINS). In: PCR in situ hybridization: a practical approach. Eds: Herrington CS, O'Leary JJ. Oxford University Press, Oxford, 1998, pp. 103-116.

7. Hopman AHN, Voorter CEM, Speel EJM, Ramaekers FCS, Vooijs GP: Detection of genetic changes in cancer by interphase cytogenetics and comparative genomic hybridization. In: In situ hybridization: principles and practice. 2

nd ed. Eds: Polak JM, McGee JO’D. Oxford

University Press, Oxford, 1998, pp. 93-122.

8. Speel EJM, Hopman AHN, Komminoth P: Signal amplification for DNA and mRNA in situ hybridization. In: Methods in Molecular Biology: In situ hybridization protocols. Ed: Darby I. Humana Press Inc, Totowa, NJ, USA, 2000, pp. 195-216.

9. Speel EJM, Ramaekers FCS, Hopman AHN: PCR-based detection of nucleic acids in cells and tissues: technical considerations on PRINS and in situ PCR and comparison with in situ hybridization. In: Methods in Molecular Biology: PCR protocols 2

nd edition: methods

and applications. Eds: Bartlett JMS, Stirling D. Humana Press Inc, Totowa, NJ, USA, 2003, pp. 405-424.

10. Speel EJM, Ramaekers FCS, Hopman AHN: Primed in situ (PRINS) nucleic acid labeling combined with immunocytochemistry to simultaneously localize DNA and proteins in cells and chromosomes. In: Methods in Molecular Biology: PCR protocols 2

nd edition: methods

and applications. Eds: Bartlett JMS, Stirling D. Humana Press Inc, Totowa, NJ, USA, 2003, pp. 453-464.

11. Lechago J, Speel EJM, Perren A, Papotti M: VIPoma. In: WHO Classification of Tumours. Pathology & Genetics of Tumours of Endocrine Organs. Chapter 4: Tumours of the endocrine pancreas. Eds: DeLellis RA, Lloyd RV, Heitz PU, Eng C. IARC Press, Lyon, France, 2004, pp. 195-197.

12. Osamura RY, Öberg K, Speel EJM, Volante M, Perren A: Serotonin-secreting tumour. In: WHO Classification of Tumours. Pathology & Genetics of Tumours of Endocrine Organs. Chapter 4: Tumours of the endocrine pancreas. Eds: DeLellis RA, Lloyd RV, Heitz PU, Eng C. IARC Press, Lyon, France, 2004, pp. 198.

13. Speel EJM, Hopman AHN, Komminoth P: Tyramide signal amplification for DNA and mRNA in situ hybridization. In: Methods in Molecular Biology, Vol. 326: In situ hybridization protocols, 2

nd ed. Ed: Darby I. Humana Press Inc, Totowa, NJ, USA, 2006, 33-60.

14. Roemen GJM, zur Hausen A, Speel EJM: Adequate tissue for adequate diagnosis: what do we really need? In: ERS Monogr (Lung Cancer) 68, 119-135, 2015. Ed: Dingemans AMC, Reck M, Westeel V. European Respiratory Society 2015. Charlesworth Press, Wakefield, UK

15. Speel EJM: HPV integration in head and neck squamous cell carcinomas: cause and consequence. In: HPV infection in head and neck cancer. Ed: Golusinsky W, Leemans CR, Dietz A. Recent Results Cancer Res 206, 57-72, 2017.

16. Perren A, Anlauf M, Klimstra DS, Klöppel G, Komminoth P, LaRosa S, Öberg K, Scarpa A, Scoazec JY, Speel EJM, Zamboni G: Insulinoma. In: WHO Classification of Tumours. Pathology & Genetics of Tumours of Endocrine Organs. Chapter 6: Tumours of the neuroendocrine pancreas. Eds: Lloyd RV, Osamura RY, Klöppel G, Rosai J. IARC Press, Lyon, France, 2017, p. 222-224.

17. Capella C, La Rosa S, Öberg K, Papotti M, Speel EJM: VIPoma. In: WHO Classification of Tumours. Pathology & Genetics of Tumours of Endocrine Organs. Chapter 6: Tumours of the neuroendocrine pancreas. Eds: Lloyd RV, Osamura RY, Klöppel G, Rosai J. IARC Press, Lyon, France, 2017, p. 232-232.

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G. Other publications

1. Speel EJM: Avidin-biotin interactions. Rice Biotechnology Quarterly 12, 40-41, 1992.

2. Speel EJM, Schutte B, Ramaekers FCS, Hopman AHN: Non-fading high sensitivity confocal fluorescence imaging for in situ hybridization and immunocytochemistry. Biorad Application Note 14, 1994.

3. Speel EJM. Detection systems for multiple-target in situ hybridization and immunocytochemistry. PhD Thesis, University of Maastricht, Maastricht, The Netherlands. University Press Maastricht (ISBN 90-5278-178-8), 1995.

4. Speel EJM, Ramaekers FCS, Hopman AHN. Multiple-target DNA in situ hybridization with enzyme-based cytochemical detection systems. In: Nonradioactive in situ hybridization application manual. Eds: Boehringer Mannheim. Boehringer, Mannheim, Germany, 1996, pp. 100-107.

5. Speel EJM, Ramaekers FCS, Hopman AHN. Combined DNA in situ hybridization and immunocytochemistry for the simultaneous detection of nucleic acid sequences, proteins, and incorporated BrdU in cell preparations. In: Nonradioactive in situ hybridization application manual. Eds: Boehringer Mannheim. Boehringer, Mannheim, Germany, 1996, pp. 110-115.

6. Jonkers YMH, Ramaekers FCS, Speel EJM. Moleculaire veranderingen tijdens de progressie van insulinomen. Kanker 31, June 2007, pp. 30-34.

7. Speel EJM, Rüland A, Meulemans EV, Fransen L, Tonk R, Baldewijns MM. UroVysion: detectie van chromosoomafwijkingen in urine middels fluorescente in situ hybridisatie ter identificatie van blaaskanker. VAP Visie 2, 2008, p. 29.

8. Speel EJM. Verbetering van de vroege diagnose van hoofd-hals kanker middels een DNA test. KWF lenteloterij 2009.

9. Bot F, Van den Ende PLA, Flikweert DC, Van der Hulst RRWJ, Hupperets PSJG, De Jong JMA, Kelleners-Smeets N, Kessler PAWH, Kremer B, Kross KW, Lacko M, Lethaus B, Peutz-Kootstra C, Speel EJM, Thissen M, Vriens BEPJ. Bourgondisch Limburg: Academische zorg op niveau. Hoofd-hals Journaal 21, nr. 41, 2009, pp. 25-26.

10. Speel EJM. Oorzaak alvleesklierkanker. Vitalia, oktober 2009, p. 9.

11. Kremer B, Speel EJM. Grotere overlevingskans bij hoofd-hals kanker. Zuid Magazine voor Zuid-Limburg, jaargang 2, nr. 7, april 2011, p. 56-57.

12. Kremer B, Speel EJM. Grotere overlevingskans bij hoofd-hals kanker. De 2e stem,

jaargang 47, nr. 224, augustus 2011, p. 26-27.

13. Swarts DRA, Ramaekers FCS, Speel EJM: Terugkeer tumor te voorspellen. Telegraaf, di 17 dec 2013.

14. Speel EJM: Identificatie van ROS1 genherschikkingen in NSCLC. Respiratory News International nr. 1, 2014.

15. Zur Hausen A, Speel EJM, Buchholtz R, Roemen GJM: Dako Omnis systeem. VAPvisie 6, 2014 p. 27-33

16. Speel EJM en Schuuring EMD: Ontwikkelingen in de moleculaire pathologie: teveel om bij te houden? Oncology News International nr. 1, febr 2015, vol 9, p.10-11.

17. Cornet I, Kaanders JHAM, Kremer B, Speel EJM: Hoofdhalskanker en HPV: hoe op maat te behandelen? Kanker Breed vol 7, nr 2, sept 2015, 26-29.

18. Lucassen A, Roemen GJM, Speel EJM: Ontwikkeling en implementatie van IDH 1/2 genmutatie analyse voor de moleculaire diagnostiek van hersentumoren. Analyse vol 70, nr 5, okt 2015, 154-155.

19. Speel EJM: Behandeling van longkanker steeds meer aangestuurd door moleculaire diagnostiek. Special "Nieuwe ontwikkelingen in de oncologie". Medidact Oncologie, juli 2016, 10-11.

Published abstracts (see 16. for details)

51

1991: Cytometry Suppl 5, 133. 1992: Anal Cell Pathol 4, 230-231; Histochem J 24, 560 and 562. 1993: Cytometry Suppl 6; Eur J Cell Biol 60 (Suppl 37), 107; Eur J Histochem 37 (Suppl), 11; Acta

Cytol 37, 594-595. 1994: Anal Cell Pathol 6, 264; Cytometry 17 (Suppl 7), 82, 83 and 92; Hum Reprod 9 (Suppl 4), 30. 1995: J. Assisted Reprod. and Genet. 27S, OC2. 1996: Acta Histochem Cytochem 29 (Suppl), 98-99, 259-260, 275-276; Cytometry 23 (Suppl 8), 90

and 107. 1997: Anal Cell Pathol 13, 100, 1997; Am J Pathol 151, 1499; Schweiz Med Wochenschr 127,

1760. 1998: Modern Pathol 11, 58A; Cytometry (Suppl 9), 43, 50, and 146-147; Pathol Res Pract 194/4,

259 and 277; Am J Pathol 153, 1660; Schweiz Med Wochenschr 128, 1870. 1999: Proceedings AACR 40, 537; Anal Cell Pathol 18, 28 and 38; Pathol Res Pract 195/5, 296,

373 and 374; Virchows Arch 435, 166, 219 and 315; JMD 1, 57; Schweiz Med Wochenschr 129, 1424-1425 and 1428.

2000: Lab Invest 80, 71A and 74A; Proceedings AACR 41, 419-420, 513 and 856; Pathol Res Pract 196, 437; Proc Roy Micr Soc 2000 (ICHC) p. 101 and 112; Schweiz Med Wochenschr 130, 1419.

2001: J Pathol 193 (Suppl), 3A, 7A, 9A and 11A; Lab Invest 81, 74A; Proceedings AACR 42, 194, 631 and 791.

2002: Lab Invest 82, 311A and 2P; Proceedings AACR 43, 632, 635, 636 and 652; Cytometry Suppl 11, 14, 16, 36, 44, 51, 70 and 71; Proceedings ASCO 21, 453a.

2003: J Clin Res Clin Oncol 129 (Suppl 2), S36; HNO 28, 151. 2004: HNO 29, 138; Proceedings AACR 45, 93, 242-243, 654, 656; Neurology 62, Suppl 5,

A546; J Int Med 255, 723-724. 2005: HNO-Info 84, 88-89; Neuro-Oncol July, 326-327; Virchows Archiv 447, 187, 188, 189-

190, 191; Eur J Med Genet 48, 501, 508. 2006: Neuroendocrinology 83, 58; Proceedings AACR 47, 99, 272, 1048-1049;

Otorinolaryngologie A Foniatrie 55, Suppl 1, 32 and 229; Dutch J Otolaryngol Head Neck Surg 12, 227.

2007: Clinical Otolaryngology 32, 158; Proceedings AACR 48, 32, 463; Dutch J Otolaryngol Head Neck Surg 13; Oral Oncol 2, Suppl, 84, 203; HNO-Info 86, 175; Virchows Archiv 451, 140, 183, 188-189, 497.

2008: Proceedings AACR 49, 1317-1318, 1321-1322; HNO-Info 87, 71, 74, 184-185; Dutch J Otolaryngol Head Neck Surg 14, 267-269.

2009: Neuroendocrinology 90, 135-137; Proceedings AACR 50, 341, 390, 447, 859-860; Dutch J Otolaryngol Head Neck Surg 15, 87; Oral Oncology Suppl 3, 90-91, 119-120, 122; Virchows Archiv 455, Suppl 1, S9, S26-27; J Thoracic Oncology 4, Suppl 1, S612; Cytopathol 20, Suppl 1, 58.

2010: Neuroendocrinology 92, 12-13; Proceedings AACR 51, 417, 1237, 1301, 1388; Dutch J Otolaryngol Head Neck Surg 16, 97-98; Hoofd-Hals Journaal 43, 17-19, 23-24, 36; HNO-Info 89, 69, 76, 78, 117-118; J Pathol Suppl 222, S14; JMD 12, 892, 909-910.

2011: Modern Pathol 24, Suppl 2s, 11A, 335A; Neuroendocrinology 94, Suppl 1, 5, 12; Proceedings AACR 52, 540, 650, 986; Dutch J Otolaryngol Head Neck Surg 17, 91, in press; Dutch J Med Microbiol 19, Suppl, S89; HNO-Abstraktband 2011, 81; J Thoracic Oncol 6, Suppl 2, S710-S712; Virchows Archiv 459, Suppl 1, S2, S29-S30, S37, S63; Onkologie 34, suppl 6, 136; Dutch J Otolaryngol Head Neck Surg 17, 224-225, 230-232.

2012: Lab Invest 92, suppl 1, 122A, 316A; Modern Pathol 25, suppl 2, 122A, 316A; Neuroendocrinology 96, suppl 1, 13-14; Eur Arch Otorhinolaryngol 269, 4, 1325, 13-27-1328, 1340, 1373; Dutch J Otolaryngol Head Neck Surg 18, 83, 221; Ann Oncol 23, suppl 9, 73, 80; J Mol Diagn 14, 677, 690, 719.

2013: J Pathol 229, suppl 1, S6, S17; Neuroendocrinology 97, in press; Proc AACR 54, in press; Dutch J Otolaryngol Head Neck Surg 19, 79; Oral Oncol 49, S6, S7, S19, S54, S77; Virchows Archiv 463 (2), 109, 128; Journal der deutschen dermatologischen gesellschaft 11 (9), 904; Int J Gynaecol Cancer 23 (8), Suppl 1, 164.

Aanvullen

52

Participation in television documentary 1. Heel de Mens, 25 years of azM, Part 6, Treatment of laryngeal cancer. MUMC-L1,

November 28, 2011. 2. "Gezond Idee" on treatment of cancer as a possible chronic disease in the near future.

September, 2014. Interviews 1. Interview in the 2009-2011 Annual Report of GROW-School for Oncology & Developmental

Biology (together with Prof. Dr. A. zur Hausen and Prof. Dr. B. Kremer), p. 42-45: The role of viruses in the development of cancer.

2. Interview in the 2012-2013 Annual Report of GROW-School for Oncology & Developmental Biology, p. 34-37: Mechanism of viral oncogenesis uncovered.

3. Interview in the Dutch newspaper "Brabants Dagblad": Working with molecules is like making puzzles. September 10, 2013.

4. Interview in Dutch journal of technicians working in Pathology (together with Prof, Dr. A. zur Hausen, Mr. R. Buchholtz and Mr. G. Roemen) on Dako Omnis systeem. VAPvisie 6, 2014 p. 27-33.

5. Interview in Oncology News International (together with Prof. Dr. E. Schuuring): Developments in molecular pathology: too much to cope with? Oncology News International nr. 1, febr 2015, vol 9, p.10-11.

6. Interview with Mrs. Astrid Joosten (Utrecht, Netherlands; May 7, 2015) as part of the developement of an online post-academic course for pulmonologists entitled: Molecular diagnostics for pulmonologists.

7. Interview with labarotory high school student A. Lucassen (together with Prof. Dr. E.J.M. Speel and Mr. G. Roemen) concerning her thesis laboratory work at the Department of Pathology, Maastricht UMC: Development and implementation of IDH 1/2 gene mutation analysis for molecular diagnostics of brin tumors. Analyse vol 70, nr 5, okt 2015, p. 154-155.

8. Interview in Medidact: "Behandeling van longkanker steeds meer aangestuurd door moleculaire diagnostiek". Special "New developments in oncology". Medidact Oncologie, july 2016, p.10-11.

9. Interview with Diaceutics on BRAF, EGFR and PDL1 testing in NSCLC. July 3, 2017. Guided tour: Guided tour at the Department of Pathology, Maastricht UMC for donors/contributors of the

Health Foundation Limburg (HFL), together with Prof. dr. A. zur Hausen (October 28, 2014).

Guided tour at the Department of Pathology, Maastricht UMC for participants of the course

Pathology for pulmonologists (co-organised by Benecke), together with pathologist Dr. L. Hillen (September 25, 2017).

Participation in the Maastricht UMC Open Day: Participation in the Pathology stand, preparation of a poster with an overview of the

activities that take place at the Department of Pathology, and guiding of interested people at the Department of Pathology (February 28, 2015).

Participation in the circulation tour on a patient with an oropharyngeal tumor, stage 8

Department of Pathology, preparation and presentation of 2 posters with an overview of the activities that take place at the Department of Pathology, and in the head and neck tumor research group (March 18, 2017).

53

16. Invited speaker at scientific seminars, workshops and congresses 1. Speel EJM: Fluorescence in situ hybridization in oncology. International Seminar on

Automation and Molecular Cytogenetics, November 18-20, 1992, Clermond-Ferrand, France.

2. Speel EJM, Ramaekers FCS, Hopman AHN: Cytochemical amplification methods for ISH and PRINS. International Seminar on PCR in situ and PRINS, March 21, 1996, Villejuif, France.

3. Hopman AHN, Ramaekers FCS, Speel EJM: In situ hybridization and PRINS, comparison of cell and tissue processing methods. International Seminar on PCR in situ and PRINS, March 21, 1996, Villejuif, France.

4. Speel EJM: Non-radioactive in situ hybridization. Workshop Merging Molecular Biology with Morphological Techniques. In situ hybridization for the cellular localization of mRNA and DNA: State of the Art 1998, July 23, 1998, San Diego, USA.

5. Speel EJM: Target and signal amplification methods to increase the sensitivity of in situ hybridization: in situ PCR or CARD? Workshop Merging Molecular Biology with Morphological Techniques. In situ hybridization for the cellular localization of mRNA and DNA: State of the Art 1998, July 23, 1998, San Diego, USA.

6. Speel EJM: Molecular genetics of endocrine pancreatic tumors. 6th Vysis User Meeting,

September 1, 1999, Cambridge, U.K. 7. Speel EJM: Molecular genetics of neuroendocrine tumors. KFM retraite, January 13-14,

2000, Groesbeek, The Netherlands. 8. Speel EJM: Use of PRINS with paraffin-embedded and frozen sections. 1

st International

Workshop on Primed In Situ Labeling, July 23-24, 2000, Fort Walton Beach, USA. 9. Speel EJM: Genetic analysis of endocrine pancreatic tumors. Seminar Department of

Pathology, September 19, 2000, Regenzburg, Germany. 10. Speel EJM: Developments in in situ hybridization and signal amplification methods and its

applications in oncology. Seminar Department of Pathology, University Hospital Nijmegen, October 2, 2000, Nijmegen, The Netherlands.

11. Speel EJM: Genetic alterations in endocrine pancreatic tumors and carcinoids. Seminar on MEN1 and endocrine tumors, Department of Medical Sciences, University Hospital Uppsala, September 18, 2002, Uppsala, Sweden.

12. Jonkers YMH, Speel EJM: Identification of genes involved in insulinoma development and progression. 3

rd Annual GROW Scientific Symposium, November 28, 2003, Vaals, The

Netherlands. 13. Speel EJM: (Pre)malignant lesions of the head and neck mucosa: Molecular recognition of

the malignant potential and association with oncogenic HPV types. Symposium “Premalignant aberrations in the head and neck region”, May 11, 2004, Born, The Netherlands.

14. Speel EJM: HPV 16/18 integration is a hallmark for (potentially) malignant lesions of the oropharyngeal mucosa. Seminar Department of Virology, June 25, 2004, Cologne, Germany.

15. Speel EJM: Molecular analysis of cancer. Key Note Lecture 11th Euregional Oncology

Meeting, October 1, 2004, Aachen, Germany. 16. Speel EJM: HPV-associated cancer of the uterine cervix and head and neck region.

Seminar Department of Pathology, May 3, 2005, Glasgow, UK. 17. Speel EJM: Molecular alterations involved in insulinoma tumorigenesis. Seminar

Department of Medical Sciences, University Hospital Uppsala, May 17, 2006, Uppsala, Sweden.

18. Speel EJM: Molecular alterations during insulinoma tumorigenesis. GROW-School for Oncology and Developmental Biology Science Day, December 14, 2007, Maastricht, The Netherlands.

19. Speel EJM: In situ hybridization. Lecture OOA Course: Molecular biology and its diagnostic implications for clinicians, VU University Medical Center, December 20, 2007, Amsterdam, The Netherlands.

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20. Speel EJM: UroVysion (FISH on urine). 5th National VAP day, April 5, 2008, Ermelo, The

Netherlands. 21. Speel EJM and Van Eijs G: Dinos and DNA. Lecture Natural History Museum Maastricht,

April 6, 2008, Maastricht, The Netherlands. 22. Speel EJM: Human papillomavirus and head and neck cancer. Seminar Rega Institute for

Medical Research, May 19, 2008, Leuven, Belgium. 23. Speel EJM: Insulinomics: identification of new prognostic indicators and therapeutical

targets by means of genomic analysis of insulinomas. 3rd

Symposium Carcinoid Syndrom: new developments in diagnostics and therapy, May 27, 2008, Utrecht, The Netherlands.

24. Speel EJM: Human papillomavirus and head and neck cancer. Seminar Department of Otorhinolaryngology & Head and Neck Surgery, University of Düsseldorf, June 25, 2008, Düsseldorf, Germany.

25. Speel EJM. The pathogenesis of HPV-related cancer. Symposium Viral Oncogenesis. 74th

Annual Meeting of the Swiss Society of Pathology, November 13, 2008, Liestal, Switzerland.

26. Speel EJM: Oncogenic and prognostic factors in head and neck carcinogenesis. GROW-School for Oncology and Developmental Biology Science Day, November 26, 2008, Maastricht, The Netherlands.

27. Speel EJM: The pathogenesis of HPV-related cancer. Seminar Department of Pathology, Clinic Rechts der Isar, January 19, 2009, Munich, Germany.

28. Speel EJM: In situ hybridization and its application in clinical diagnosis: sarcomas. Lecture Molecuar Diagnostics Day, February 27, 2009, Utrecht, The Netherlands.

29. Speel EJM: Oncogenic and prognostic factors in head and neck carcinogenesis. Seminar Department of Pathology, Ninewells Hospital, April 6, 2009, Dundee, UK.

30. Speel EJM: Genetics of insulinoma. Symposium Genetics of GI endocrine tumors, 22nd

European Congress of Pathology, September 8, 2009, Florence, Italy.

31. Speel EJM: HPV and chromosomal instability as prognostic factors in head and neck cancer. Seminar Department of Pathology, Friedrich Alexander University of Erlangen-Nürnberg, September 11, 2009, Erlangen, Germany.

32. Speel EJM: Additional molecular technologies applied to urine sediments: Urovysion. Lecture Veldhuizen Course, November 19, 2009, Noordwijkerhout, The Netherlands.

33. Speel EJM: Genomic and signal transduction events promoting insulinoma. Netherlands Society for Gastro-enterology Meeting, March 18, 2010, Veldhoven, The Netherlands.

34. Speel EJM: Oncogenic and prognostic factors in head and neck carcinogenesis. Seminar Division of Pathology, San Luigi Hospital, May 20, 2010, Turin, Italy.

35. Speel EJM: Applications of Urovysion to bladder cancer detection. Molecular Abbott Urovysion meeting, June 22, 2010, Utrecht, The Netherlands.

36. Speel EJM: HPV and head and neck tumors. 198th Scientific Meeting of the Pathology

Society of Great Britain & Ireland, July 1, 2010, St Andrews, UK. J Pathol Suppl 222, S14, 2010.

37. Speel EJM: Early metastatic behavior of HPV-induced oropharyngeal cancer. AHNS 2010 research Workshop on the biology, prevention and treatment of head & neck cancer, October 30, 2010, Arlington, USA.

38. Speel EJM: Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. Association for Molecular Pathology 2010 Annual Meeting, November 19, 2010, San Jose, USA.

39. Speel EJM: Chromosomal instability as biomarker for the development and recurrence of head and neck cancer. Spring Meeting of the Dutch Society of Oral and Maxillofacial Surgery, March 18, 2011, Maastricht, The Netherlands.

40. Speel EJM: Oncogenic and prognostic factors in head and neck carcinogenesis. 1st

AIOCC-IHNS Congress, April 8, 2011, Alba, Italy. 41. Speel EJM: Oncogenic and prognostic factors in head and neck carcinogenesis. Seminar

Department of Pathology, University of Bern, May 16, 2011, Bern, Switzerland. 42. Speel EJM: An update on the molecular biology of HPV-associated HNSCC. Round table

discussion: Human papillomaviruses and head and neck cancer. 82. Jahresversammlung

55

der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, June 3, 2011, Freiburg, Germany.

43. Speel EJM: Chromosomal instability predicts the progression of premalignant head and neck lesions. Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum Meeting, September 6, 2011, Bruges, Belgium.

44. Speel EJM: Neuro-endocrine pancreatic tumors: molecular mechanisms and histopathologic classification. Symposium Recent Developments in diagnostics and treatment of neuro-endocrine tumors, November 10, 2011, Thorn, The Netherlands.

45. Speel EJM: HPV-related head and neck cancer: hype, or hope for treatment? Annual Congress of the Dutch Paramedical Society Head and Neck Tumors, February 3, 2012, Utrecht, The Netherlands.

46. Speel EJM: Molecular biology of HPV-related head and neck cancer. 2. Symposium zur experimentellen und klinischen Forschung in der Kopf-Hals-Onkologie, February 11, 2012, Lubeck, Germany.

47. Speel EJM: Molecular diagnostics of lung carcinomas: current practice and future perspectives. New developments in lung cancer diagnosis and treatment, May 24, 2012, Leende, The Netherlands.

48. Speel EJM: Oncogenic and prognostic factors in Head and Neck tumorgenesis. 5th

European Conference on Head and Neck Oncology, April 18, 2012, Poznan, Poland. 49. Speel EJM: Tumor heterogeneity in the molecular diagnostics of malignant tumors.

Consequences for targeted therapy. 2nd IKNL Post-USCAP Symposium, June 27, 2012, Elsloo, The Netherlands.

50. Speel EJM: Lung cancer: Molecular pathways and diagnostics. Post-ASCO Symposium Lung Cancer, August 27, 2012, Roosteren, The Netherlands.

51. Speel EJM: Molecular diagnostics of lung carcinomas: current practice and future perspectives. New developments in lung cancer diagnosis and treatment, September 20, 2012, Vaalsbroek, The Netherlands.

52. Speel EJM: How cancer develops. An update. (Wie entsteht krebs? Der Wissenstand der Grundlagenforschung). 9. Überregionaler Neuroendokriner Tumortag, Oktober 13, 2012, Leverkusen, Germany.

53. Speel EJM: HPV and p16INK4A overexpression in non small cell lung cancer. 4th ETOP Meeting, November 10, 2012, Dublin, Ireland.

54. Speel EJM: Molecular OncoPathology: Identifying genomic alterations for cancer diagnosis, prognosis and therapy selection. Symposium at University of Faro, November 30, 2012, Faro, Portugal.

55. Speel EJM: HPV and p16 detection in lung tumors. ETOP Pathology Meeting, January 11, 2013, Zurich, Switzerland.

56. Speel EJM: Next generation sequencing for mutation analysis in routine molecular diagnostic pathology. Symposium Molecular Diagnostics: the next generation, February 1, 2013, Maastricht, The Netherlands.

57. Speel EJM: Next generation sequencing for mutation analysis in routine molecular diagnostic pathology. 1st Nucleomics User Meeting, March 21, 2013, Leuven, Belgium.

58. Speel EJM: Next generation molecular diagnostics. IKNL Limburg Pathology Meeting, October 21, 2013, Maastricht, The Netherlands.

59. Speel EJM: Molecular pathways and diagnostics. Post-WCLC 2013 Symposium, December 4, 2013, Roosteren, The Netherlands.

60. Speel EJM: Molecular pathology of cutaneous melanoma. Symposium Melanoma Actual, January 29, 2014, Roermond-Herten, The Netherlands.

61. Speel EJM: KRAS and EGFR gene mutation frequency in lung adenocarcinomas in Limburg and Maastricht UMC. Symposium EGFR mutation analysis anno 2014, May 22, 2014, Roosteren, The Netherlands.

62. Speel EJM: Molecular pathology of lung tumors: new developments. Post-ASCO Symposium Lung Cancer, June 24, 2014, Roosteren, The Netherlands.

63. Speel EJM: Everybody's gotta learn sometimes how to identify deregulated pathways in cancer cells. Pfizer sales conference, September 9, 2014, Oosterbeek, The Netherlands.

56

64. Speel EJM: Development of molecular markers in neuropathology. Symposium Neuro-oncology: State of the art treatment of gliomas anno 2014, November 3, 2014, Eindhoven, The Netherlands.

65. Speel EJM: Application of molecular diagostics on cytological material. Veldhuizen course on urine and gynacological cytology, November 6-7, 2014, Noordwijkerhout, The Netherlands.

66. Speel EJM: HPV integration in HNSCC. International symposium on HPV infection in head and neck cancer, November 13-14, 2014, Poznan, Poland.

67. Speel EJM: Molecular pathology and diagnostics of lung carcinomas. Symposium at the National Institute of Lung diseases, November 16, 2014, Budapest, Hungary.

68. Speel EJM: Virus integration in the host cell genome. 1st International symposium on tumor-host interaction in head and neck cancer, January 22-24, 2015, Essen, Germany.

69. Speel EJM: Detection of ROS1 gene rearrangements in non small cell lung cancer. ETOP Pathologist meeting, February 6, 2015, Zurich, Switzerland

70. Speel EJM: HPV-related head and neck cancer. Hype, or hope for treatment? Presentation for Paramedical Working Group Head and Neck Tumors, MUMC, May 11, 2015, Maastricht, The Netherlands

71. Speel EJM: HPV integration in head and neck squamous cell carcinomas. Symposium tgv promotie C. Bommelje, July 8, 2015, ErasmusMC Rotterdam, The Netherlands

72. Speel EJM: Molecular pathways and diagnostics of lung cancer. Post-WCLC 2015 symposium, October 12, 2015, Roosteren, The Netherlands

73. Speel EJM: Predicting the conversion of premalignancy to oral squamous cell carcinoma (SCC). BAOMS and IAOO Symposium Controversies in the management of cancer and precancer of the oral cavity, November 27, 2015, London, UK

74. Speel EJM: Starting up a Molecular tumor Board within OncoZON. OncoZON Lung cancer meeting. January 18, 2016, Thorn, The Netherlands

75. Speel EJM: Molecular diagnostics within the new NSCLC guideline on diagnosis and treatment. Regional pathology tissue section evening. March 21, 2016, Maastricht, The Netherlands

76. Speel EJM: Value of CT guided biopsies. Requirements for the pathologist. Biopsy procedural workshop (Cook Medical). March 21, April 11, May 10, June 21, 2016, Maastricht, The Netherlands

77. Speel EJM: Molecular diagnostics in oncopathology in the Netherlands: state of the art and future perspectives. 14th National symposium of microscopic morphology with international participation. May 5, 2016, Tirgu Mures, Romania

78. Speel EJM: SKML Her2Neu (ERBB2) circulation test 2015. Annual meeting SKML-section Pathology. May 26, 2016, Amersfoort, The Netherlands

79. Speel EJM: Viral load, gene expression and mapping of viral integration. International symposium on HPV infection in head and neck cancer. November 3, 2016, Leipzig, Germany.

80. Speel EJM: HPV integration in head and neck squamous cell carcinomas: cause and consequence. 8th International Congress on HPV & Polyomavirus in skin cancer. November 18, 2016, Maastricht, The Netherlands.

81. Speel EJM: Molecular diagnostics in oncopathology: state of the art and future perspectives. Pulmo Update meeting, November 29, 2016, Maastricht, The Netherlands.

82. Speel EJM: Molecular pathology of head and neck squamous cell carcinoma. 36th International Symposium for oral and maxillofacial surgeons and dentists. February 9, 2017, St Anton am Arlberg, Austria

83. Speel EJM: The expression of IGF signaling pathway genes is frequently elevated in pancreatic neuroendocrine tumors, but is downregulated in metastases. 14th Annual ENETS conference. March 9, 2017, Barcelona, Spain

84. Speel EJM, J. Derks: Critical view on the current diagnostics of neuro-endocrine lung tumors and future perspectives. Annual Week of Pathology/Pathology Days. March 29, 2017, Ede, The Netherlands

85. Speel EJM: Molecular Oncopathology. Post-ASCO meeting, June 19, 2017, Roermond, The Netherlands

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86. Speel EJM: Maastricht UMC+, Department of Pathology: overview of activities. Mammatyper meeting, August 30, 2017, Biontech, Mainz, Germany

87. Speel EJM: PDL1 Immunohistochemistry, Regional Pathology Meeting, September 12, 2017, Heerlen, The Netherlands

88. Speel EJM: PDL1 staining: first experiences. Regional Oncology South East Netherlands (OncoZON) Lung tumor meeting, September 19, 2017, Thorn, The Netherlands

89. Speel EJM: Beyond the WHO 2015 classification of lung neuroendocrine tumors. Genomics of lung NETs & Identification of biomarkers of prognosis and therapy. 29th European Congress of Pathology. September 4, 2017, Amsterdam, The Netherlands

90. Speel EJM: Advances in molecular pathology and regional collaboration. Meeting Oncology Committee Zuyderland Hospital, September 27, 2017, Sittard, The Netherlands

91. Speel EJM: HPV infection in head and neck cancer: biology, diagnosis, and impact on prognosis and treatment. European Meeting on Molecular Diagnostics 2017, October 11, 2017, Noordwijk aan Zee, The Netherlands.

92. Speel EJM: Acquired resistance: mechanisms and diagnostic techniques. Meeting Oncology Update 2017, October 31, 2017, Utrecht, The Netherlands

93. Speel EJM: PDL1, a simple immunohistochemical staining procedure? Post-ESP / ESMO / WCLC meeting, November 13, 2017, Roermond, The Netherlands

17. Oral presentations at scientific congresses based on submitted abstracts 1. Speel EJM, Schutte B, Ramaekers FCS, Hopman AHN: Bleaching properties and

application of alkaline phosphatase-fast red for sensitive fluorescence in situ hybridization detection by confocal scanning laser microscopy. 3D Imaging Sciences in Microscopy Congress, March 9-11, 1992, Amsterdam, The Netherlands.

2. Hopman AHN, Speel EJM, Poddighe PJ, Herbergs J, Voorter CEM, Ramaekers FCS: Cyto- and molecular genetics in cytology. 21

st European Congress of Cytology, September

12-16, 1993, Vienna, Austria. Acta Cytologica 37, 594-595, 1993. 3. Hopman AHN, Speel EJM, Poddighe PJ, Herbergs J, Voorter CEM, Ramaekers FCS:

Fluorescence in situ hybridization on interphase nuclei to study chromosomal aberrations in tumor. Eur J Histochem 37, Suppl, 11, 1993.

4. Speel EJM, Jansen M, Ramaekers FCS, Hopman AHN: A novel triple-color in situ hybridization detection procedure for brightfield microscopy, which can be combined with immunocytochemistry. 3

rd Conference of the European Society for Analytical Cellular

Pathology, May 16-20, 1994, Grenoble, France. Anal Cell Pathol 6, 264, 1994 (abstract 253).

5. Speel EJM, Herbergs J, Ramaekers FCS, Hopman AHN: Simutaneous detection of cell cycle, genomic and phenotypic parameters by means of combined immunocytochemistry and FISH. 3

rd Conference of the European Society for Analytical Cellular Pathology, May

16-20, 1994, Grenoble, France. Anal Cell Pathol 6, 264, 1994 (abstract 254). 6. Hopman AHN, Speel EJM, Voorter C, Ramaekers FCS: Detection of tumor heterogeneity

by combination of FISH and phenotypic parameters. 3rd

Conference of the European Society for Analytical Cellular Pathology, May 16-20, 1994, Grenoble, France. Anal Cell Pathol 6, 264, 1994 (abstract 255).

7. Martini E, Speel EJM, Coonen E, Ramaekers FCS, Geraedts JPM, Hopman AHN: New methodologies for ISH on chromosomal DNA in human spermatozoa. 10

th Annual Meeting

of the ESHRE, 1994, Brussels, Belgium. Human Reprod 9, Suppl 4, 30, 1994 (abstract 060).

8. Martini E, Speel EJM, Hopman AHN, Geraedts JPM: Detection of cytogenetic abnormalities in spermatozoa of a 47,XYY male with a novel method. Meeting of the Dutch-Flemish Sociaty for Fertility Studies, April 29, 1995, Nijmegen, The Netherlands. J Assisted Reprod Genet 27S, 1995 (abstract OC2).

9. Hopman AHN, Speel EJM, Ramaekers FCS: Multiple target in situ hybridizations based on fluorescence and brightfield microscopy. CYTO 95, July 3-7, 1995, Southampton, UK.

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10. Hopman AHN, Voorter CEM, Ummelen M, Kamps M, Speel EJM, Ramaekers FCS: Comparative genomic hybridization and FISH, complementary techniques to study genomic changes in solid tumors. 10

th International Congress of Histochemistry and Cytochemistry,

August 18-23, 1996, Kyoto, Japan. Acta Histochimica Cytochimica 29, Suppl, 98-99, 1996 (abstract S10-2).

11. Hopman AHN, Herbergs J, Speel EJM, Arends JW, Ramaekers FCS: Analysis of chromosome copy numbers in thin tissue sections of tumor cell areas with high nuclear density. 10

th International Congress of Histochemistry and Cytochemistry, August 18-23,

1996, Kyoto, Japan. Acta Histochimica Cytochimica 29, Suppl, 259-260, 1996 (abstract Ms9-3).

12. Speel EJM, Ramaekers FCS, Hopman AHN: Sensitive multiple-target FISH combining peroxidase-mediated deposition of differently fluorochrome-labeled tyramides. 10

th

International Congress of Histochemistry and Cytochemistry, August 18-23, 1996, Kyoto, Japan. Acta Histochimica Cytochimica 29, Suppl, 275-276, 1996 (abstract Ms10-5).

13. Hopman AHN, Speel EJM, Claessen SMH, Ramaekers FCS: Triple-color in situ hybridization on paraffin embedded tissue sections for brightfield microscopical analysis. 5

th

ESACP Congress, May 25-29, 1997, Oslo, Norway. Anal Cell Pathol 13, 100, 1997 (abstract 169).

14. Speel EJM, Saremaslani P, Komminoth P, Hopman AHN: Card signal amplification: an efficient method to increase the sensitivity of DNA and mRNA in situ hybridization. 3

rd

Annual Meeting of the Association for Molecular Pathology, November 12-15, 1997, San Diego, USA. Am J Pathol 151, 1499, 1997.

15. Perren A, Roth J, Muletta-Feurer S, Saremaslani P, Speel EJM, Heitz PU, Komminoth P: Clonal analysis of sporadic pancreatic endocrine tumors. 63. Jahresversammlung Schweizerische Gesellschaft für Pathologie, 1997. Schweiz Med Wochenschr 127, 1760, 1997.

16. Perren A, Roth J, Muletta-Feurer S, Saremaslani P, Speel EJM, Heitz PU, Komminoth P: Clonal analysis of sporadic pancreatic endocrine tumors. Annual Meeting of the United States and Canadian Academy of Pathology, February 28-March 6, 1998, Boston, USA. Modern Pathol 11, 58A, 1998.

17. Speel EJM, Saremaslani P, Hopman AHN, Komminoth P: Increased sensitivity of mRNA in-situ hybridization on routinely fixed, paraffin-embedded tissue sections using signal amplification with different haptenized tyramides. ISAC XIX International Congress, February 28-March 5, 1998, Colorado Springs, USA. Cytometry, Suppl 9, 43, 1998.

18. Hopman AHN, Speel EJM, Claessen SMH, Ramaekers FCS: Triple-color in situ hybridization on paraffin embedded tissue sections for brightfield microscopy. ISAC XIX International Congress, February 28-March 5, 1998, Colorado Springs, USA. Cytometry, Suppl 9, 50, 1998.

19. Speel EJM, Saremaslani P, Roth J, Heitz PU, Werner M, Hopman AHN, Komminoth P: Increased sensitivity of mRNA in-situ hybridization on routinely fixed, paraffin-embedded tissue sections using signal amplification with haptenized tyramides. 82. Tagung der Deutsche Gesellschaft für Pathologie, June 3-6, 1998, Kassel, Germany. Pathol Res Pract 194, 259, 1998 (abstract 183).

20. Görtz B, Muletta-Feurer S, De Krijger RR, Rütimann K, Speel EJM, Saremaslani P, Roth J, Heitz PU, Komminoth P: MEN-1 gene mutations in neuroendocrine and adrenocortical tumors. 82. Tagung der Deutsche Gesellschaft für Pathologie, June 3-6, 1998, Kassel, Germany. Pathol Res Pract 194, 277, 1998 (abstract 252).

21. Perren A, Roth J, Muletta-Feurer S, Saremaslani P, Speel EJM, Heitz PU, Komminoth P: Clonal analysis of benign and malignant, sporadic pancreatic endocrine tumours. 82. Tagung der Deutsche Gesellschaft für Pathologie, June 3-6, 1998, Kassel, Germany. Pathol Res Pract 194, 277, 1998 (abstract 254).

22. Görtz B, Roth J, Krähenmann A, De Krijger RR, Speel EJM, Heitz PU, Komminoth P: MEN1 gene mutations in sporadic neuroendocrine (carcinoid) tumors of the lung and gastrointestinal are not restricted to foregut neoplasms. Association for Molecular Pathology Annual Meeting, November 6-8, 1998, Crystal City, USA. Am J Pathol 153, 1660, 1998 (abstract ST6).

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23. Speel EJM, Richter J, Moch H, Egenter C, Roth J, Saremaslani P, Rüttiman K, Barghorn A, Heitz PU, Komminoth P: Comparative genomic hybridization analysis of sporadic endocrine pancreatic tumors. Association for Molecular Pathology Annual Meeting, November 6-8, 1998, Crystal City, USA. Am J Pathol 153, 1660, 1998 (abstract ST7).

24. Speel EJM, Richter J, Moch H, Egenter C, Roth J, Saremaslani P, Rütimann K, Barghorn A, Heitz PU, Komminoth P: Analysis of sporadic endocrine pancreatic tumors by means of comparative genomic hybridization. 64. Jahresversammlung Schweizerische Gesellschaft für Pathologie, Neuenburg, November 12-14, 1998. Schweiz Med Wochenschr 128, 1870, 1998.

25. Barghorn A, Rütimann K, Saremaslani P, Muletta S, Speel EJM, Roth J, Heitz PU, Komminoth P: Loss of heterozygosity of 3p25 in sporadic neuroendocrine pancreatic tumors: a malignancy marker? 64. Jahresversammlung Schweizerische Gesellschaft für Pathologie, Neuenburg, November 12-14, 1998. Schweiz Med Wochenschr 128, 1870, 1998.

26. Hopman AHN, Kamps M, Haesevoets A, Speel EJM, Ramaekers FCS: Comparison of different bicolor ISH detection methods to analyze chromosomal aberrations in interphase cells. 6

th European Society for Analytical Cellular Pathology Congress, April 7-11, 1999,

Heidelberg, Germany. Anal Cell Pathol 18, 28, 1999 (abstract A073). 27. MacVille M, Speel EJM, Hopman AHN, Van der Laak J, Hanselaar A, McNamara G,

Soenksen D, Ried T. Spectral pathology: multicolor spectral imaging of chromogenic dyes in pathological specimens. 6

th European Society for Analytical Cellular Pathology

Congress, April 7-11, 1999, Heidelberg, Germany. Anal Cell Pathol 18, 38, 1999 (abstract A100).

28. Speel EJM, Richter J, Moch H, Egenter C, Zhao J, Saremaslani P, Rüttiman K, Barghorn A, Roth J, Heitz PU, Komminoth P: Comparative genomic hybridization analysis reveals marked genetic differences between endocrine pancreatic tumor subtypes. 83. Tagung der Deutsche Gesellschaft für Pathologie, May 26-29, 1999, Jena, Germany. Pathol Res Pract 195, 374, 1999 (abstract 389).

29. Volante M, Papotti M, Roth J, Saremaslani P, Speel EJM, Lloyd RV, Heitz PU, Bussolati G, Komminoth P: Mixed medullary-follicular thyroid carcinoma: molecular evidence for a dual origin of tumor components. 17

th European Congress of Pathology, September 18-23,

1999, Barcelona, Spain. Virchows Archiv 435, 166, 1999 (abstract O-001). 30. Speel EJM: Detection and amplification sytems for sensitive, multiple-target DNA and RNA

in situ hybridization: looking inside cells with a spectrum of colors. Robert Feulgen Prize Lecture 1999, 41

st Symposium of the Society for Histochemistry, September 25, 1999,

Gargellen, Austria. Histochem Cell Biol 112, 89-113, 1999. 31. Speel EJM, Meier D, Matter C, Muletta-Feurer S, Saremaslani P, Zhao J, De Krijger RR,

Volante M, Van Asseldonk M, Roth J, Heitz PU, Komminoth P: Losses of chromosome 11q in sporadic endocrine pancreatic and neuroendocrine tumors: presence of another tumor suppressor gene telomeric of MEN1? 65. Jahresversammlung der Schweizerischen Gesellschaft für Pathologie, November 4-6,1999, Aarau, Switzerland. Schweiz Med Wochenschr 129, 1424, 1999 (abstract 12).

32. Janzer RC, Speel EJM, Scheidweiler AF, Zhao J, Saremaslani P, Komminoth P, De Tribolet N, Majdi R, Bosman FT: Unusual chromosomal losses and gains detected by comparative genomic hybridization in a meningothelial meningioma progressing to atypical and anaplstic meningioma. 65. Jahresversammlung der Schweizerischen Gesellschaft für Pathologie, November 4-6,1999, Aarau, Switzerland. Schweiz Med Wochenschr 129, 1425, 1999 (abstract 15).

33. Zhao J, De Krijger RR, Speel EJM, Matter C, Saremaslani P, Roth J, Heitz PU, Komminoth P: Genomic alterations in gastrointestinal and bronchial neuroendocrine tumors: marked differences indicating diversity in molecular pathogenesis. Annual Meeting of the Association for Molecular Pathology, November 4-7, 1999, St. Louis, USA. J Mol Diagn 1, 57, 1999 (abstract S21).

34. Speel EJM, Zhao J, Meier D, Matter C, Muletta-Feurer S, Saremaslani P, De Krijger RR, Van Asseldonk M, Roth J, Heitz PU, Komminoth P: Analysis of chromosome 11q in sporadic endocrine pancreatic and neuroendocrine tumors: presence of another tumor

60

suppressor gene telomeric of MEN1? Annual Meeting of the Association for Molecular Pathology, November 4-7, 1999, St. Louis, USA. J Mol Diagn 1, 57, 1999 (abstract S22).

35. Speel EJM, Kamps M, Schapers RFM, Ramaekers FCS, Hopman AHN: Genetic analysis of urothelial carcinoma in situ with FISH for chromosomes 1, 7, 9 and 9p21: its impact on understanding bladder cancer development. 4

th Symposium Oncology in Maastricht,

February 25, 2000, Maastricht, The Netherlands. 36. Speel EJM, Kamps M, Schapers RFM, Ramaekers FCS, Hopman AHN: Genetic analysis

of urothelial carcinoma in situ with FISH for chromosomes 1, 7, 9 and 9p21: its impact on understanding bladder cancer development. 7

th Euregional Oncology Meeting, March 10,

Aachen, Germany. 37. Barghorn A, Speel EJM, Farspour B, Saremaslani P, Rütimann, Roth J, Heitz PU,

Komminoth P: Allelic loss at 6q is associated with malignancy in sporadic endocrine pancreatic tumors. 84. Tagung der Deutsche Gesellschaft für Pathologie, June 7-10, 2000, Kiel, Germany. Pathol Res Pract 196, 437, 2000 (abstract 368).

38. Barghorn A, Speel EJM, Farspour B, Zhao J, Saremaslani P, Schmid S, Perren A, Roth J, Heitz PU, Komminoth P: A novel tumor suppressor gene locus in sporadic endocrine pancreatic tumors at 6q22? 66. Jahresversammlung Schweizerische Gesellschaft für Pathologie, Zürich, November 2-4, 2000. Schweiz Med Wochenschr 130, 1419, 2000 (abstract 3).

39. Speel EJM, Van der Toorn PPG, Veltman JA, Bot FJ, De Jong JMA, Manni JJ, Ramaekers FCS, Hopman AHN: Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells. 182

nd Meeting of the

Pathological Society of Great Britain and Ireland, January 3-5, 2001, Maastricht, The Netherlands. J Pathol 193, Suppl, 3A, 2001 (abstract 14).

40. Hopman AHN, Smedts F, Ummelen M, Speel EJM, Ramaekers FCS: Highly sensitive detection of human papillomvirus in cervical CIN lesions, microinvasive and invasive carcinoma. 182

nd Meeting of the Pathological Society of Great Britain and Ireland, January

3-5, 2001, Maastricht, The Netherlands. J Pathol 193, Suppl, 7A, 2001 (abstract 30). 41. Speel EJM, Schaart G, Haesevoets A, Ummelen M, Ramaekers FCS, Hopman AHN:

Sensitive multiple-target fluorescence detection systems for immunocytochemistry and in situ hybridization using tyramide signal amplification. 182

nd Meeting of the Pathological

Society of Great Britain and Ireland, January 3-5, 2001, Maastricht, The Netherlands. J Pathol 193, Suppl, 9A, 2001 (abstract 39).

42. Hopman AHN, Kamps M, Schapers RFM, Speel EJM, Ramaekers FCS: Genetic analysis of urothelial carcinoma in situ with FISH for chromosomes 1, 7 and 9: its impact on understanding bladder cancer development. 182

nd Meeting of the Pathological Society of

Great Britain and Ireland, January 3-5, 2001, Maastricht, The Netherlands. J Pathol 193, Suppl, 11A, 2001 (abstract 44).

43. Barghorn A, Speel EJM, Farspour B, Schmid S, Saremaslani P, Perren A, Roth J, Heitz PU, Komminoth P: Allelic loss at 6q is strongly associated with malignancy in sporadic endocrine pancreatic tumors. Annual Meeting of the United States and Canadian Academy of Pathology, March 3-9, 2001, Atlanta, USA.. Lab Invest 81, 74A, 2001 (abstract 420).

44. Speel EJM, Claessen SMH, Van Mierlo A, Haesevoets A, Hopman AHN, Ramaekers FCS, Loosen I, Arends J-W, Van de Wouw AJ, Joosten S, Griffioen A, Hillen HFP: Genetic characterization of different distant metastases in patients with cancers of unknown primary tumor. 8

th Euregional Oncology Meeting, April 19, 2001, Maastricht, The Netherlands.

45. Hopman AHN, Kamps M, Schapers RFM, Speel EJM, Sauter G, Ramaekers FCS: Genetic analysis of urothelial carcinoma in situ with FISH for chromosomes 1, 7 and 9: its impact on understanding bladder cancer development. 14

th International Congress of Cytology, May

27-31, 2001, Amsterdam, The Netherlands (abstract 261). 46. Hopman AHN, Smedts F, Ummelen M, Dignef W, Speel EJM, Ramaekers FCS: Highly

sensitive detection of human papillomvirus in cervical CIN lesions, microinvasive and invasive carcinoma. 14

th International Congress of Cytology, May 27-31, 2001, Amsterdam,

The Netherlands (abstract 262). 47. Hopman AHN, Kamps M, Vriezema J, Speel EJM, Schalken J, Ramaekers FCS:

Fluorescence in situ hybridization of bladder irrigation specimens for the detection of

61

urothelial carcinoma. 14th International Congress of Cytology, May 27-31, 2001,

Amsterdam, The Netherlands (abstract 263). 48. Hafkamp HC, Speel EJM, Haesevoets A, Ramaekers FCS, Bot FJ, Manni JJ, Hopman

AHN: A subset of head and neck squamous cell carcinomas that overexpresses p53 demonstrates integration of HPV 16/18 DNA as detected by FISH. 4

th European Workshop

on Basic Biology of Head and Neck Cancer. Recent Advances in Molecular Biology, October 4-6, 2001, Amsterdam, The Netherlands.

49. Hafkamp HC, Speel EJM, Ramaekers FCS, Hopman AHN, Bot FJ, Manni JJ: Detection of HPV 16/18 integration in a subset of head and neck squamous cell carcinomas that overexpresses p53. SEOHS Symposium, November 15-16, 2001, Nijmegen, The Netherlands.

50. De Krijger RR, Claessen SMH, Van der Ham F, Van Unnik AJM, Hulsbergen-Van de Kaa CM, Van Leuven L, Van Noesel M, Speel EJM: Comparative genomic hybridization analysis of pleuropulmonary blastomas. Annual Meeting United States and Canadian Academy for Pathology, February 23-March 1, 2002, Chicago, USA. Lab Invest 82, 311A, 2002.

51. Speel EJM, Claessen SMH, Haesevoets A, Hopman AHN, Loosen I, Arends J-W, Joosten S, Ramaekers FCS, Van de Wouw AJ, Hillen HJP: Genetic characterization of different distant metastases in patients with cancers of unknown primary tumor. XXI Congres of the International Society for Analytical Cytology, May 3-9, 2002, San Diego, USA. Cytometry, Suppl 11, 36, 2002 (abstract 44061).

52. Hopman AHN, Kamps M, Speel EJM, Schapers RFM, Sauter G, Ramaekers FCS: Differential loss of chromosome 9p11-q12 and 9p21 in carcinoma in situ with or without concomitant malignant bladder tumors. XXI Congres of the International Society for Analytical Cytology, May 3-9, 2002, San Diego, USA. Cytometry, Suppl 11, 44, 2002 (abstract 44030).

53. Hopman AHN, Speel EJM, Haesevoets A, Ramaekers FCS, Levenson RM: Improved identification of multicolor chromogenic in situ hybridization signals by the application of new spectral imaging methods. XXI Congres of the International Society for Analytical Cytology, May 3-9, 2002, San Diego, USA. Cytometry, Suppl 11, 51, 2002 (abstract 44032).

54. Manni JJ, Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Hopman AHN, Ramaekers FCS, Speel EJM: Integration of genomic HPV 16 DNA is associated with p16

INK4A overexpression in tonsillar carcinomas. 74. Jahresversammlung der Deutschen

Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, May 28-June 1, 2003, Dresden, Germany. HNO-Informationen 28, 151, 2003.

55. Hafkamp HC, Manni JJ, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Hopman AHN, Ramaekers FCS, Speel EJM: Integration of HPV 16 DNA is associated with p16

INK4A

overexpression in tonsillar carcinomas. 10th Euregional Oncology Meeting, Juni 26, 2003,

Maastricht, The Netherlands. 56. Hafkamp HC, Manni JJ, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Hopman

AHN, Ramaekers FCS, Speel EJM: Integration of genomic HPV 16 DNA is associated with p16

INK4A overexpression in tonsillar carcinomas. VII Symposion on Research in Head and

Neck Cancer, September 4-6, 2003, Düsseldorf, Germany. J Clin Res Clin Oncol 129 (Suppl 2), S36, 2003 (abstract TH23).

57. Manni JJ, Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Hopman AHN, Ramaekers FCS, Speel EJM: Integration of genomic HPV 16 DNA is associated with p16

INK4A overexpression in tonsillar carcinomas. 2

nd European Conference on Head and

Neck Cancer, October 16-18, 2003, Lille, France. 58. Hafkamp HC, Manni JJ, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Voogd AC,

Hopman AHN, Ramaekers FCS, Speel EJM: HPV 16-associated tonsillar carcinomas show p16

INK4A overexpression and an improved prognosis. Pathology Days, April 22-23,

2004, Ede, The Netherlands. 59. Twijnstra A, Claessen SMH, Blaauw G, Janzer R, Speel EJM: Comparative genomic

hybridization analysis of primary and recurrent meningiomas. 56th Annual Meeting of the

62

American Academy of Neurology, April 24-May 1, 2004, San Francisco, USA. Neurology 62,Suppl 5, A546, 2004 (abstract S68.004).

60. Klussmann JP, Dinh S, Wittekindt C, Turek L, Smith E, Speel EJM, Weissenborn SJ, Pfister H, Stennert E: HPV-DNA integration in oropharyngeal carcinomas. 75. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, May 19-23, 2004, Bad Reichenhall, Germany. HNO-Informationen 29, 138, 2004.

61. Jonkers YMH, Claessen SMH, Komminoth P, Perren A, Verhofstad AA, Hofland LJ, De Krijger RR, Slootweg PJ, Veltman JA, Geurts van Kessel A, Ramaekers FCS, Speel EJM: Genomic alterations in benign and malignant insulinomas as revealed by conventional and array CGH. 1

st Marie Curie Conference on arrayCGH and Molecular Cytogenetics,

September 29-October 2, 2004, Cambridge, UK. 62. Vitale G, van Eijck CH, van Koetsveld PM, Speel EJM, Colao A, van der Wansem K,

Erdmann JI, Lamberts SWJ, Hofland LJ: Potent inhibition of human pancreatic cancer cell growth by beta-interferon. 3rd BIC Conference – Pancreatic Cancer, October 8-9, 2004, Wiesbaden, Germany.

63. Speel EJM, Haesevoets A, Groenstein A, Bot FJ, Bergshoeff VE, Claessen SMH, Hopman AHN, Ramaekers FCS, Manni JJ: Chromosome instability as detected by FISH predicts malignant outgrowth of precursor lesions of the larynx. 4

th International Symposium on

Advances in Head and Neck Cancer, January 19-22, 2005, Marburg, Germany. 64. Speel EJM, Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Voogd AC,

Hopman AHN, Ramaekers FCS Manni JJ: HPV 16 in relation to smoking as prognostic indicators for patients with tonsillar carcinomas. 4

th International Symposium on Advances

in Head and Neck Cancer, January 19-22, 2005, Marburg, Germany. 65. Van Nederveen FH, De Krijger RR, Dannenberg H, Dinjens WNM, Speel EJM: Can CGH

discriminate between paragangliomas and pheochromocytomas in patients with a SDHD mutation? Pathology Days, April 21-22, 2005, Ede, The Netherlands.

66. Speel EJM, Klingenberg B, Hafkamp HC, Haesevoets A, Slootweg PJ, Weissenborn SJ, Klussmann JP, Manni JJ: Is p16

INK4A overexpression a reliable biomarker for oncogenic

human papillomavirus infection in normal tonsils? 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, May 4-8, 2005, Erfurt, Germany. HNO-Informationen 84, 88-89, 2005.

67. Manni JJ, Haesevoets A, Bot F, Speel EJM: Durch FISH nachgewiesene Chromosomale Instabilität ist ein Indikator für maligne Entartung von Präkursor-Läsionen des Larynx. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, May 4-8, 2005, Erfurt, Germany. HNO-Informationen 84, 157, 2005.

68. Vitale G, van Eijck CH, van Koetsveld PM, Speel EJM, Colao A, Lombardi G, van der Wansem K, Erdmann JI, Lamberts SWJ, Hofland LJ: Potent inhibition of human pancreatic cancer cell growth by beta-interferon. ENDO 2005, July 4-7, 2005, San Diego, USA.

69. Speel EJM, Meulemans EV, Rüland AM, Pauwels P: Evaluation of MDM2 gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/wel-differentiated liposarcomas in paraffin-embedded material. 20

st European Congress of

Pathology, September 3-8, 2005, Paris, France. Virchows Archiv 447, 187, 2005 (abstract O-157).

70. Speel EJM, Jonkers YMH, Claessen SMH, Perren A, Schmid S, Komminoth P, Verhofstad AA, Hofland LJ, De Krijger RR, Slootweg PJ, Ramaekers FCS: Chromosomal instability predicts the malignant phenotype in sporadic insulinomas. 20

st European Congress of

Pathology, September 3-8, 2005, Paris, France. Virchows Archiv 447, 188, 2005 (abstract O-160).

71. Speel EJM, Aarts M, Dannenberg H, Claessen SMH, DeLeeuw RJ, Van Nederveen F, Verhofstad AA, Dinjens WNM, Lam WL, De Krijger RR: Conventional and 1p-specific microarray-based CGH analysis of sporadic and syndrome-related pheochromocytomas. 20

st European Congress of Pathology, September 3-8, 2005, Paris, France. Virchows Archiv

447, 189-190, 2005 (abstract O-164). 72. Speel EJM, Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Voogd AC,

Hopman AHN, Ramaekers FCS, Manni JJ: HPV 16 in relation to smoking as prognostic

63

indicators for patients with tonsillar carcinomas. 20st

European Congress of Pathology, September 3-8, 2005, Paris, France. Virchows Archiv 447, 191, 2005 (abstract O-169).

73. Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman JA, Speel EJM: Frequnt loss of chromosomes 11q and 22q loci in insulinomas. 3

rd Annual

ENETS Conference, March 22-24, 2006, Prague, Czech Republic. Neuroendocrinology 83, 58, 2006 (abstract B13).

74. Bergshoeff E, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers FCS, Manni JJ, Speel EJM: Chromosome instability as detected by FISH predicts malignant outgrowth of precursor lesions of the larynx. 3

rd World Congress of the International Federation of

Head & Neck Oncologic Societies, June 27-July 1, 2006, Prague, Czech Republic. Otorinolaryngologie A Foniatrie 55, Suppl 1, 32, 2006 (abstract O31).

75. Klussmann JP, Lehnen M, Claessen SMH, Manni JJ, Weissenborn SJ, Pfister H, Preuss S, Speel EJM: CGH analysis of oropharyngeal squamous cell carcinomas that contain or lack oncogenic HPV-16. 23

rd International Papillomavirus Conference and Clinical Workshop,

September 1-7, 2006, Prague, Czech Republic (abstract PS 21-5). 76. Klussmann JP, Reimers N, Gültekin E, Weissenborn SJ,

Preuss SF, Herbert P, Guntinas-

Lichius O, Speel EJM: Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. 23

rd International Papillomavirus Conference

and Clinical Workshop, September 1-7, 2006, Prague, Czech Republic (abstract PS 21-6). 77. Speel EJM, Claessen SMH, Hopman AHN, Weissenborn SJ, Klussmann JP, Manni JJ:

Genomic analysis of oropharyngeal carcinomas that contain or lack HPV-16. 209th Dutch

Otolaryngology and Head and Neck Surgery Meeting, November 2-3, 2006, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 12, 227, 2006; Clinical Otolaryngology 32, 158, 2007.

78. Mooren JJ, Manni JJ, Hafkamp HC, Klingenberg B, Voogd AC, Bot FJ, Claessen SMH, Ramaekers FCS, Kremer B, Speel EJM: Cell cycle protein expression patterns in HPV-containing and –lacking tonsillar squamous cell carcinomas and association with prognosis: a role for p21? Pathology Days, April 10, 2007, Ede, The Netherlands.

79. Klussmann JP, Claessen SMH, Preuss S, Stenner M, Lehnen M, Manni JJ, SpeelEJM: Die genetische Analyse (CGH) von HPV-positiven und HPV-negativen Oropharynxkarzinomen zeigt signifikante Unterschiede mit Bedeutung für die Prognose. 78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, München, May 17-20, 2007. HNO-Informationen 86, 175, 2007.

80. Mooren JJ, Manni JJ, Hafkamp HC, Klingenberg B, Voogd AC, Bot FJ, Claessen SMH, Hopman AHN, Ramaekers FCS, Kremer B, Speel EJM: Cell cycle protein expression patterns in HPV-containing and –lacking tonsillar squamous cell carcinomas and association with prognosis: a role for p21? 1

st World Congress of the International Academy

of Oral Oncology, May 17-20, 2007, Amsterdam, The Netherlands. Oral Oncol 2, Suppl, 84, 2007 (abstract (O85).

81. Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder WW, De Krijger RR, Verhofstad AAJ, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM: DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. 21

st European Congress of Pathology,

September 8-13, 2007, Istanbul, Turkey. Virchows Archiv 451, 140, 2007 (abstract OP10-7).

82. Mooren J, Manni JJ, Hafkamp HC, Klingenberg B, Voogd AC, Bot FJ, Claessen SMH, Hopman AHN, Ramaekers FCS, Kremer B, Speel EJM:

Cell cycle Protein Expression

Patterns in HPV-containing and –lacking Tonsillar Squamous Cell Carcinomas and Association with Prognosis: a Role for p21? 21

st European Congress of Pathology,

September 8-13, 2007, Istanbul, Turkey. Virchows Archiv, 451, 183, 2007 (abstract OP27-5).

83. Bergshoeff VE, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers FCS, Manni

JJ, Speel EJM: Chromosome instability as detected by FISH predicts progression of premalignant lesions of the larynx. 21

st European Congress of Pathology, September 8-13,

2007, Istanbul, Turkey. Virchows Archiv, 451, 188-189, 2007 (abstract OP29-3).

64

84. Speel EJM: Evaluation of expression and amplification of MDM2 and CDK4 genes as potential tools for the diagnosis of ALT/WDL. Science Day, Department of Pathology, Academic Hospital Maastricht, October 17, 2007, Maastricht, The Netherlands.

85. Klussmann JP, Preuss S, Weinell A, Molitor M, Stenner M, Speel EJM, Wittekindt C, Hoffmann TK, Guntinas-Lichius O: Die Survivin Expression und der p16/HPV-Status beim Oropharynxkarzinom interagieren und haben eine signifikante prognostische Bedeutung. 79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bonn, Germany, May 1-4, 2008. HNO-Informationen 87, 71, 2008.

86. Mooren J, Kremer B, Hafkamp HC, Speel EJM, Bot FJ, Voogd AC, Klussmann JP, Hopman AHN, Manni JJ:

Bedeutung des Expressionsmusters von Zellzyklusproteinen in

HPV-positieven und –negatieven Plattenepithelkarzinomen der Tonsillen für die Prognose: Spielt p21Cip1/WAF1 eine Rolle? 79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bonn, Germany, May 1-4, 2008. HNO-Informationen 87, 74, 2008.

87. Bergshoeff VE, Speel EJM, Manni JJ, Kremer B: Chromosome instability in tumour resection margins of oral cancers as a predictor for (loco)regional recurrence. 79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Bonn, Germany, May 1-4, 2008. HNO-Informationen 87, 184-185, 2008.

88. Bergshoeff EV, Hopman AHN, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM: CIN in OSCC resection margins predicts risk for recurrence. 3

rd European Conference on

Head and Neck Oncology, Zagreb, Croatia, May 8-10, 2008. 89. Mooren JJ, Claessen SMH, Haesevoets A, Hopman AHN, Manni JJ, Kremer B, Ramaekers

FCS, Speel EJM: Chromosome 1 and 7 changes in HPV-positive and -negative TSCC. 3rd

European Conference on Head and Neck Oncology, Zagreb, Croatia, May 8-10, 2008.

90. De Rosario L, Bergshoeff VE, De Jong JMA, Van den Ende PLA, Speel EJM, Kremer B: Results of laserresection and radiotherapy of carcinoma in situ of the larynx are dependent on their localization. 213

th General Meeting of the Netherlands Society of

Otorhinolaryngology and Head and Neck Surgery, November 14, 2008, Maastricht, The Netherlands. Dutch J Otolaryngol Head Neck Surg 14, 267, 2008.

91. Mooren JJ, Speel EJM, Hopman AHN, Manni JJ, Ramaekers FCS, Kremer B: Chromosome 1 and 7 changes in HPV-positive and -negative tonsillar squamous cell carcinomas. 213

th General Meeting of the Netherlands Society of Otorhinolaryngology and

Head and Neck Surgery, November 14, 2008, Maastricht, The Netherlands. Dutch J Otolaryngol Head Neck Surg 14, 268, 2008.

92. Straetmans JMJAA, Kremer B, Vos I, Speel EJM: HPV is associated with oropharyngeal tumors a favorable prognosis in non-smoking patients. 213

th General Meeting of the

Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, November 14, 2008, Maastricht, The Netherlands. Dutch J Otolaryngol Head Neck Surg 14, 268-269, 2008.

93. Bergshoeff EV, Kremer B, Hopman AHN, Ramaekers FCS, Manni JJ, Speel EJM: Chromosomal instability in resection margins of oral squamous cell carcinomas predicts risk for recurrence. 213


Otorhinolaryngology and Head and Neck Surgery, November 14, 2008, Maastricht, The Netherlands. Dutch J Otolaryngol Head Neck Surg 14, 269, 2008.

94. Olthof NC, Kremer B, Henfling M, Ramaekers FCS, Speel EJM: Characterization of HPV-positive head and neck squamous cell carcinoma cell lines. 214


Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, April 23-24, 2009, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 15, 87, 2009.

95. Mooren JJ, Claessen SMH, Haesevoets A, Hopman AHN, Ramaekers FCS, Klussmann JP, Manni JJ, Kremer B, Speel EJM: Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV and a favorable prognosis. 100

th Annual Meeting of the

AACR, April 18-22, 2009, Denver, USA. Proceedings AACR 50, 447, 2009 (abstract 1858). 96. Speel EJM, Stenner M, Yosef B, Huebbers C, Preuss SF, Dienes HP, Klussmann JP,

Odenthal M: Mesenchymal transformation during tumor progression in HPV-related oropharyngeal cancer. 25

th International Papillomavirus Conference, May 8-14, 2009, Malmö,

Sweden (abstract O-17.03).

65

97. Mooren JJ, Claessen SMH, Haesevoets A, Hopman AHN, Ramaekers FCS, Klussmann JP, Manni JJ, Kremer B, Speel EJM: Association between chromosome stability , HPV and prognosis in tonsillar carcinoma. 25

th International Papillomavirus Conference, May 8-14,

2009, Malmö, Sweden (abstract O-17.06). 98. Mooren JJ, Speel EJM, Klussmann JP, Kremer B: Chromosome stability in tonsillar

squamous cell carcinoma is associated with HPV and a favorable prognosis. 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Rostock, Germany, May 20-24, 2009. HNO-Informationen 88, 2009.

99. Bergshoeff VE, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM: Chromosome

instability predicts progression of premalignant lesions of the larynx. 2nd

World Congress of the International Academy of Oral Oncology, July 8-11, 2009, Toronto, Canada. Oral Oncology Suppl 3, 90-91, 2009 (abstract O103).

100. Mooren JJ, Claessen SMH, Haesevoets A, Hopman AHN, Ramaekers FCS, Klussmann JP, Manni JJ, Kremer B, Speel EJM: Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV and a favorable prognosis. 2

nd World Congress of the

International Academy of Oral Oncology, July 8-11, 2009, Toronto, Canada. Oral Oncology Suppl 3, 119-120, 2009 (abstract O191).

101. Farshadpour F, Konings S, Speel EJM, Slootweg PJ, Koole R, Kummer JA: Etiologic significance of human papillomavirus in oropharyngeal squamous cell carcinoma in relation to tobacco and alcohol. 2

nd World Congress of the International Academy of Oral Oncology,

July 8-11, 2009, Toronto, Canada. Oral Oncology Suppl 3, 122, 2009 (abstract O198). 102. Straetmans JMJAA, Olthof N, Vos I, Speel EJM, De Jong J, Kremer B: Prognostic value of

HPV and cervical metastasis in oropharyngeal squamous cell carcinomas. 2nd

World Congress of the International Academy of Oral Oncology, July 8-11, 2009, Toronto, Canada. Oral Oncology Suppl 3, 122, 2009 (abstract O200).

103. Schmidt A, Speel EJM, Willi N, Zsikla V, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Offner F, Sauter G, Cathomas G: Patterns of MCV in Merkel cell carcinoma (MCC) analyzed by fluorescence in situ hybridization (FISH). 22

nd European Congress of

Pathology, September 4-9, 2009, Florence, Italy. Virchows Archiv 455, Suppl 1, S9, 2009 (abstract OP3.2).

104. Speel EJM, Mooren JJ, Hopman AHN, Ramaekers FCS, Claessen SMH, Klussmann JP, Kremer B: Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV and a favorable prognosis. 22

nd European Congress of Pathology, September 4-9,

2009, Florence, Italy. Virchows Archiv 455, Suppl 1, S26, 2009 (abstract OP7.8). 105. Speel EJM, Slootweg PJ, Van der Laak JA, Otte-Höller I, Bergshoeff VE, Haesevoets A,

Takes RP, Fleskens AJ: Aneuploidy detection by DNA image cytometry and FISH recognizes pregressive premalignant head and neck lesions. 22

nd European Congress of

Pathology, September 4-9, 2009, Florence, Italy. Virchows Archiv 455, Suppl 1, S27, 2009 (abstract OP7.11).

106. Samijo N, Vervoort PSAM, Tonk RJW, Middendorp I, Rüland A, Roemen G, Meulemans EV, Van de Beek C, Baldewijns MM, Speel EJM: Unmasking bladder cancer cells in urine by combining liquid-based cytology and Urovysion on a single slide. 35

th European

Congress of Cytology, September 27-30, 2009, Lisbon, Portugal. Cytopathol 20, Suppl 1, 58, 2009 (abstract FP1.101).

107. Hamers RMPT, Siebers TJH, Otte-Höller I, Zwijnenberg IR, Van der Laak JAWM, Merkx MAW, Kremer B, Slootweg PJ, Speel EJM: Aneuploidy detection by DNA image cytometry and FISH recognizes progressive premalignant head and neck lesions. Pathology Days, April 8-9, 2010, Zeist, The Netherlands (abstract OV3).

108. Hamers RMPT, Siebers TJH, Otte-Höller I, Zwijnenberg IR, Van der Laak JAWM, Merkx MAW, Kremer B, Slootweg PJ, Speel EJM: Aneuploidy detection by DNA image cytometry and FISH recognizes progressive premalignant head and neck lesions. 216

th General

Meeting of the Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, April 16-17, 2010, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 16, 97, 2010; Hoofd-Hals Journaal 43, 36, 2010.

109. Mooren JJ, Gültekin E, Claessen SMH, Haesevoets A, Huebbers CU, Dienes HP, Weissenborn SJ, Kremer B, Speel EJM, Klussmann JP: P16

INK4A immunostaining patterns

66

differentiate between the presence of high and low risk human papillomavirus types in head and neck dysplasias and papillomas. 216


Otorhinolaryngology and Head and Neck Surgery, April 16-17, 2010, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 16, 97-98, 2010; Hoofd-Hals Journaal 43, 36, 2010.

110. Kross KW, Mooren JJ, Hopman AHN, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM: Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV and a favorable prognosis. 22

nd Annual Meeting of the Scandinavian Society for Head and Neck

Oncology, April 22-24, 2010, Hurtigruten, Norway. 111. Kross KW, Bergshoeff VE, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM:

Chromosome instability predicts progression of premalignant lesions of the larynx. 22nd

Annual Meeting of the Scandinavian Society for Head and Neck Oncology, April 22-24, 2010, Hurtigruten, Norway.

112. Klussmann JP, Stenner M, Yosef B, Preuss SF, Dienes HP, Odenthal M, Speel EJM: Bei HPV-assoziierten Tonsillenkarzinomen sind die nukleäre Translokation von ß-Catenin und die Verminderung der E-cadherin Expression ein frühes Ereignis bei der Tumorprogression. 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Wiesbaden, Germany, May 13-16, 2010. HNO-Informationen 89, 69, 2010.

113. Mooren JJ, Gültekin E, Claessen SMH, Haesevoets A, Huebbers CU, Dienes HP, Weissenborn SJ, Kremer B, Speel EJM, Klussmann JP: P16

INK4A immunostaining patterns

differentiate between the presence of high and low risk human papillomavirus types in head and neck dysplasias and papillomas. 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Wiesbaden, Germany, May 13-16, 2010. HNO-Informationen 89, 76, 2010.

114. Olthof NC, Hoffmann TK, Klussmann JP, Kremer B, Henfling M, Ramaekers FCS, Speel EJM: Characterization of HPV-positive head and neck squamous cell carcinoma cell lines. 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Wiesbaden, Germany, May 13-16, 2010. HNO-Informationen 89, 78, 2010.

115. Hamers RMPT, Merkx MAW , Kremer B, Speel EJM, Siebers TJH, Haesevoets A,

Zwijnenberg IR, Voogd AC, Slootweg PJ, Ramaekers FCS: Chromosomal instability predicts the progression of premalignant oral lesions. 81. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Wiesbaden, Germany, May 13-16, 2010. HNO-Informationen 89, 117-118, 2010.

116. Hamers RMPT, Siebers TJH, Haesevoets A, Zwijnenberg IR, Voogd AC, Ramaekers FCS, Merkx MAW, Kremer B, Slootweg PJ, Speel EJM: Chromosomal instability predicts the progression of premalignant oral lesions. 4th World Congress of the International Federation of Head and Neck Oncological Societies, Seoul, South-Korea, June 15-19, 2010.

117. Olthof NC, Hoffmann TK, Klussmann JP, Kremer B, Henfling M, Hopman AHN, Ramaekers FCS, Speel EJM: Characterization of HPV-positive head and neck squamous cell carcinoma cell lines. 4th World Congress of the International Federation of Head and Neck Oncological Societies, Seoul, South-Korea, June 15-19, 2010.

118. Mooren JJ, Gültekin E, Claessen SMH, Haesevoets A, Huebbers CU, Dienes HP, Weissenborn SJ, Klussmann JP, Kremer B, Speel EJM: Marked differences in p16

INK4A

immunostaining between head and neck dysplasias and papillomas containing high or low risk human papillomavirus. 4th World Congress of the International Federation of Head and Neck Oncological Societies, Seoul, South-Korea, June 15-19, 2010.

119. Kremer B, Manni JJ, Mooren JJ, Speel EJM: Chromosome stability in tonsillar squamous cell carcinomas is associated with HPV16 and a favorable prognosis. Collegium Oto-Rhino-Laryngologicom Amicitiae Sacrum, Budapest, Hungary, August 22-25, 2010.

120. Siebers TJH, Hamers RMPT, Otte-Höller I, Speel EJM, Kremer B, Van der Laak JAWM, Slootweg PJ, Merkx MAW: Chromosomal instability predicts the progression of premalignant oral lesions. EACMFS 2010 Congress, Bruges, Belgium, September 14-17, 2010.

67

121. Leusink FKJ, Van Hooff SR, Kummer JA, Van Diest PJ, Koole R, Roepman P, Van den Brekel MWM, Merkx TA, Jansen JC, Schuuring E, Speel EJM, Brakenhoff RH, Baatenburg de Jong RJ, Slootweg PJ, Holstege FCP, Takes RP. Multi-center validation of a lymph node metastasis gene-expression signature for head and neck squamous cell carcinomas. 1

st Young Researchers Day NWHHT, Amsterdam, The Netherlands, September 22, 2010.

Hoofd-Hals Journaal 43, 17-18, 2010. 122. Straetmans JMJAA, Mujagic Z, Henfling M, Hopman AHN, Vent J, Klussmann JP, Kremer

B, Speel EJM: Diagnostic and prognostic value of HPV detection in neck metastases of unknown primary origin. 1

st Young Researchers Day NWHHT, Amsterdam, The

Netherlands, September 22, 2010. Hoofd-Hals Journaal 43, 19, 2010. 123. Olthof NC, Henfling M, Hopman AHN, Ramaekers FCS, Kremer B, Speel EJM: HPV 16 is

integrated in 3 HPV-positive head and neck squamous cell carcinoma cell lines. 1st Young

Researchers Day NWHHT, Amsterdam, The Netherlands, September 22, 2010. Hoofd-Hals Journaal 43, 23, 2010.

124. Siebers TJH, Hamers RMPT, Otte-Höller I, Speel EJM, Kremer B, Van der Laak JAWM, Slootweg PJ, Merkx MAW: The value of ploidy in premalignant lesions of the oral mucosa. 1

st Young Researchers Day NWHHT, Amsterdam, The Netherlands, September 22, 2010.

Hoofd-Hals Journaal 43, 23-24, 2010. 125. Fleskens AJHM, Bergshoeff VE, Voogd AC, Van Velthuysen MLF, Bot FJ, Speel EJM,

Kremer B, Takes RP, Slootweg PJ: Interobserver variability of premalignant laryngeal lesions. 1

st Young Researchers Day NWHHT, Amsterdam, The Netherlands, September

22, 2010. Hoofd-Hals Journaal 43, 24, 2010. 126. Litjens R, Theelen W, Speel EJM, Herfs M, Reijans M, Simons G, Ramaekers FCS, Somja

J, Delvenne P, Hopman AHN. Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. KWF Symposium on Translational Oncology, Ede, The Netherlands, September 27, 2010 (abstract 22).

127. Leusink FKJ, Van Hooff SR, Kummer JA, Van Diest PJ, Koole R, Roepman P, Van den Brekel MWM, Merkx TA, Jansen JC, Schuuring E, Speel EJM, Brakenhoff RH, Baatenburg de Jong RJ, Slootweg PJ, Holstege FCP, Takes RP. Multi-center validation of a lymph node metastasis gene-expression signature for head and neck squamous cell carcinomas. KWF Symposium on Translational Oncology, Ede, The Netherlands, September 27, 2010 (abstract 30).

128. Mujagic Z, Straetmans JMJAA, Henfling M, Hopman AHN, Vent J, Klussmann JP, Kremer B, Speel EJM: Diagnostic and prognostic value of HPV detection in neck metastases of unknown primary origin. 217


Otorhinolaryngology and Head and Neck Surgery, November 18-19, 2010, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 16, 211-212, 2010; Hoofd-Hals Journaal 44, 2010, in press.

129. Speel EJM, Theelen W, Herfs M, Reijans M, Simons G, Meulemans EV, Baldewijns MM, Ramaekers FCS, Somja J, Delvenne P, Hopman AHN: Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV 16/18 MLPA assay. AMP Annual Meeting, November 18-20, 2010, SanJose, USA. JMD 12, 892, 2010 (abstract ID86).

130. Olthof NC, Straetmans JMJAA, Snoeck R, Ramaekers FCS, Speel EJM, Kremer B: The next generation of treatment strategies for HPV-related head and neck squamous cell carcinomas: where do we go? 218


Otorhinolaryngology and Head and Neck Surgery, April 7-8, 2011, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 17, 91, 2011.

131. Haugg A, Pantulu ND, Pallasch C, Kurz AK, Kassem A, Frenzel L, Sodenkamp S, Kvasnicka HM, Speel EJM, Wendtner C, Zur Hausen A: Detection of Merkel cell polyomavirus in chronic lymphocytic leukaemia cells by fluorescent in situ hybridization (FISH). Annual Meeting of the Dutch Society for Medical Microbiology, April 18-20, 2011, Papendal, The Netherlands. Dutch J Med Microbiol 19, Suppl, S89, 2011 (abstract O181).

132. Klussmann JP, Langer C, Wittekindt C, Pons-Kuhnemann J, Brittinger-Schade C, Rau J, Semrau R, Von Knebel Doeberitz M, Speel EJM: Implementierung des HPV-Status in

68

klinischen Studien beim Oropharynxkarzinom. Inzidenzen, Nachweismethoden und Studiedesign. 82. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Freiburg, Germany, June 1-5, 2011. HNO-Abstraktband 2011, 81, 2011.

133. Speel EJM, Huysentruyt CJR, Baldewijns MM, Ruland AM, Tonk RJW, Vervoort PSAM, Smits KM, Van de Beek C:

Modified UroVysion scoring criteria increase the urothelial

carcinoma detection rate in case of equivocal urinary cytology. 23rd

European Congress of Pathology, August 27-September 1, 2011, Helsinki, Finland. Virchows Archiv 459, Suppl 1, S63 (abstract OFP-20-007).

134. Speel EJM, Haugg A, Pantulu ND, Pallasch C, Kurz AK, Kassem A, Frenzel L, Sodenkamp S, Kvasnicka HM, Wendtner C, Zur Hausen A: Identification of Merkel cell polyomavirus in chronic lymphocytic leukemia cells by fluorescence in situ hybridization (FISH). 23

rd

European Congress of Pathology, August 27-September 1, 2011, Helsinki, Finland. Virchows Archiv 459, Suppl 1, S29-S30 (abstract OFP-10-001).

135. Speel EJM, Bergshoeff VE, Siebers TJH, Fleskens AJHM, Van der Laak JAWM, Merkx MAW, Takes RP, Slootweg PJ, Manni JJ, Kremer B: Chromosomal instability predicts the progression of premalignant head and neck lesions. 23

rd European Congress of Pathology,

August 27-September 1, 2011, Helsinki, Finland. Virchows Archiv 459, Suppl 1, S37 (abstract OFP-12-006).

136. Speel EJM, Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, De Herder WW, De Krijger RR, Smit EF, Thunnissen FB, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS: 11q22.3-q25 deletions are associated with atypical lung carcinoids and poor clinical outcome. 23

rd European Congress of Pathology, August 27-September 1,

2011, Helsinki, Finland. Virchows Archiv 459, Suppl 1, S2 (abstract PL-01-004). 137. Speel EJM, Bergshoeff VE, Siebers TJH, Fleskens AJHM, Van der Laak JAWM, Merkx

MAW, Takes RP, Slootweg PJ, Manni JJ, Kremer B: Chromosomal instability predicts the progression of premalignant head and neck lesions. Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum Meeting, September 5-7, 2011, Bruges, Belgium (abstract 17).

138. Huebbers CU, Olthof NC, Kolligs J, Preuss SF, Drebber U, Kremer B, Speel EJM, Klussmann JP: Analysis of HPV integration sites in oropharyngeal carcinomas. 27

th

International Papillomavirus Conference and Clinical Workshop, September 17-22, 2011, Berlin, Germany (abstract O-21.02).

139. Straetmans JMJAA, Vent J, Henfling M, Haesevoets A, Haidl B, Huebbers CU, Ramaekers FCS, Speel EJM, Klussmann JP, Kremer B: Value of HPV in neck metastasis of unknown primary tumours. 27

th International Papillomavirus Conference and Clinical Workshop,

September 17-22, 2011, Berlin, Germany (abstract O-16.08). 140. Litjens R, Theelen W, Ummelen M, Ossel J, Reijans M, Simons G, Ramaekers FCS, Speel

EJM, Kruitwagen R, Hopman AHN: The positive predictive value of the HPV MLPA assay in cervical cytology is higher than with conventional screening methods. 27

th International

Papillomavirus Conference and Clinical Workshop, September 17-22, 2011, Berlin, Germany (abstract OP-217).

141. Speel EJM, Huebbers CU, Preuss SF, Kolligs J, Kremer B, Klussmann JP: Integration of human papillomavirus type 6 marks malignant transformation in a patient with juvenile respiratory papillomatosis. 219


Otorhinolaryngology and Head and Neck Surgery, November 17-18, 2011, Groningen, The Netherlands. Dutch J Otolaryngol Head Neck Surg 17, 224.

142. Olthof NC, Hübbers CU, Ramaekers FCS, Klussmann JP, Kremer B, Speel EJM: Analysis of HPV integration sites in oropharyngeal carcinomas. 219


Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, November 17-18, 2011, Groningen, The Netherlands. Dutch J Otolaryngol Head Neck Surg 17, 224-225.

143. Nelissen RC, Bergshoeff VE, Kremer B, Speel EJM: Evaluation of criteria for the identification of chromosomal instability in head & neck premalignant lesions assessed by FISH. 219

th General Meeting of the Netherlands Society of Otorhinolaryngology and Head

and Neck Surgery, November 17-18, 2011, Groningen, The Netherlands. Dutch J Otolaryngol Head Neck Surg 17, 230-231.

69

144. Pierssens DDCG, Lethaus B, Bergshoeff VE, Ruland A, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of oral cancers is a predictor of (loco)regional recurrence. 219



145. Straetmans JMJAA, Vente J, Klussmann JP, Speel EJM, Kremer B: Approach and outcome of neck metastasis in unknown primary tumors (UPT’s): a comparative study between Maastricht and Köln. 219



146. Speel EJM, Huebbers CU, Olthof NC, Kolligs J, Preuss SF, Drebber U, Kremer B, Klussmann JP: Analysis of HPV Integration Sites in Oropharyngeal Squamous Cell Carcinomas. 101st Annual Meeting of the USCAP, March 17-23, 2012, Vancouver, Canada. Lab Invest 92, suppl 1, 316A (abstract 1329). Modern Pathol 25, suppl 2, 316A (abstract 1329).

147. Swarts DRA, Van Neste L, Henfling M, Van Suylen RJ, Volante M, Ramaekers FCS, Van Criekinge W, Van Engeland M, Speel EJM: Genome-wide expression profiling reveals downregulation of OTP and CD44 and upregulation of RET as indicators of poor prognosis in lung carcinoids. 9th Annual ENETS Conference, March 7-9, 2012, Copenhagen, Denmark. Neuroendocrinology 96, suppl 1, 13-14, 2012 (abstract B37).

148. Pierssens DDCG, Bergshoeff VE, Lethaus B, Kessler P, Ruland A, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of oral cancers is a predictor of local recurrence. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1325 (abstract OP21).

149. Speel EJM, Bergshoeff VE, Haesevoets A, Nelissen RC, Ramaekers FCS, Kremer B: Definition of chromosome instability in head and neck epithelium by establishing a ratio between chromosome 1 and 7 using fluorescence in situ hybridization. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1327 (abstract OP25).

150. Huebbers CU, Olthof NC, Kolligs J, Ramaekers FCS, Preuss S, Drebber U, Kremer B, Speel EJM, Klussmann JP: Human papillomavirus 16 integration in oropharyngeal squamous cell carcinomas often occurs in genes involved in tumorigenesis. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1327 (abstract OP26).

151. Fleskens AJHM, Bergshoeff VE, Van der laak JAWM, Otte-Höller I, Speel EJM, Slootweg PJ, Takes RP: Predictive value for malignant progression of simultaneous assessment of DNA ploidy and biomarker expression in laryngeal intraepithelial lesions. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1328 (abstract OP27).

152. Mooren JJ, Gültekin E, Straetmans JMJAA, Haesevoets A, Huebbers CU, Dienes HP, Wieland U, Kremer B, Speel EJM, Klussmann JP: Strong P16

INK4A-immunostaining predicts

the presence of high-risk human papillomavirus in (pre)malignant lesions of the head and neck mucosa. 220

th General Meeting of the Netherlands Society of Otorhinolaryngology

and Head and Neck Surgery, April 26-27, 2012, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 18, 83.

153. Blackhall F, Peters S, Kerr KM, O'Byrne K, Hager H, Sejda A, Soltermann A, Dooms C, Felip E, Marchetti A, Speel EJM, Price N, Savic S, de Jong J, Martorell M, Thunnissen E, Bubendorf L, Dafni O, Rosell R, Stahel RA: Prevalence and clinical outcomes for patients with ALK gene rearrangement in Europe: preliminary results from the European Thoracic Oncology Platform Lungscape project. ESMO 2012 Congress, September 28-October 2, 2012, Vienna, Austria. Ann Oncol 23, suppl 9, 73 (abstract 1670).

154. Pramana J, Mooren JJ, Speel EJM, Kremer B, Begg A, van den Brekel M: EGFR overexpressie voorspelt een ongunstige overleving in vergevorderde HPV-positieve orofarynxcarinomen behandeld met chemoradiatietherapie. 221


Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, November 8-9, 2012, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 18, 221.

70

155. Swarts DRA, Henfling ME, Van Neste L, Van Suylen RJ, Dingemans AM, Dinjens WNM, Haesevoets A, Rudelius M, Thunnissen E, Volante M, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: CD44 and OTP are strong prognostic markers for pulmonary carcinoids. Joint meeting of the Pathological Society of Great Britain & Ireland and the Dutch Pathological Society, Winter Meeting, January 8-9, Utrecht, The Netherlands. J Pathol 229, suppl 1, S6.

156. Speel EJM, Olthof NC, Preuss SF, Klussmann JP, Huebbers CU, Kremer B: HPV16-

E2/E4, -E6 and -E7 genes and HPV disrupted human genes show large variation in expression levels in OSCC independent of the viral physical status. 222

th General Meeting

of the Netherlands Society of Otorhinolaryngology and Head and Neck Surgery, April 25-26, 2013, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 19, 79.

157. Olthof NC, Huebbers CU, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Drebber U, Lam WL, Vucic E, Kremer B, Klussmann JP, Speel EJM: HPV16-E2/E4, -E6 AND -E7 genes and HPV-disrupted human genes show large variation in expression levels in OSCC independent of the viral physical status. 4th World Congress of the International Academy of Oral Oncology, May 15-18, Rhodes, The Netherlands. Oral Oncol 49, S6 (abstract OP006).

158. Pierssens DDCG, van der Heijden S, Lethaus B, Kessler P, Bergshoeff EV, Ruland A, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of oral cancers is a predictor of local recurrence. 4th World Congress of the International Academy of Oral Oncology, May 15-18, Rhodes, The Netherlands. Oral Oncol 49, S7, 2013 (abstract OP008).

159. Mooren JJ , Pramana J, de Jong M, van de Brekel MW, van Velthuysen ML, Kremer B, Begg AC, Speel EJM: EGFR overexpression predicts unfavourable survival in advanced HPV-positive oropharyngeal cancer treated by chemoradiation therapy. 4th World Congress of the International Academy of Oral Oncology, May 15-18, Rhodes, The Netherlands. Oral Oncol 49, S19, 2013 (abstract OP040).

160. Straetmans JMJAA, Vent J, Lacko M, Speel EJM, Huebbers CU, Semrau R, Hoebers F, Mujagic Z, Klussman JP, Preuss S, Kremer B: Differences in management of neck metastases of unknown primary origin in two european centres: Consequences for future strategies. 4th World Congress of the International Academy of Oral Oncology, May 15-18, Rhodes, The Netherlands. Oral Oncol 49, S54, 2013 (abstract OP128).

161. Melchers LJ, Samaniego-Cameron B, Witjes M, Holewijn J, Mastik MF, van der Laan BFAM, van Dijk BAC, van der Vegt B, Speel EJM, Roodenburg JLN, Schuuring E: HPV epidemic also in previously low prevalence regions: Data on tonsillar and base-of-tongue carcinomas from the northern Netherlands. 4th World Congress of the International Academy of Oral Oncology, May 15-18, Rhodes, The Netherlands. Oral Oncol 49, S77, 2013 (abstract OP195).

162. Haugg A, Speel EJM, Rennspiess D, Cathomas G, Paasinen A, Becker J, Schrama D, zur Hausen A: Does P16 Immunostaining correlate with the Presence of Merkel Cell Polyomavirus in Merkel Cell Carcinomas? 97. Jahrestagung der Deutschen Gesellschaft für Pathologie e.V., May 23-26, 2013, Heidelberg, Germany.

163. Haugg A, Speel EJM, Rennspiess D, Cathomas G, Paasinen A, Becker J, Schrama D, zur Hausen A: Does P16 Immunostaining correlate with the Presence of Merkel Cell Polyomavirus in Merkel Cell Carcinomas? DNA Tumor Virus Meeting, July 22-27, 2013, Birmingham, UK.

164. Sturm B, Fleskens SJ, Bot FJ, van Velthuysen ML, Speel EJM, Slootweg PJ, van der Laak JAWM: Larynx virtual microscopy validation study. 25th European Congress of Pathology, August 31-September 4, 2013, Lisbon, Portugal. Virchows Archiv 463 (2), 109 (abstract OFP-04-009).

165. Zur Hausen A, Rennspiess D, Winnepenninckx V, Speel EJM, Kurz AK: Early B cell differentiation in Merkel cell carcinomas indicates cellular ancestry. 25th European Congress of Pathology, August 31-September 4, 2013, Lisbon, Portugal. Virchows Archiv 463 (2), 128, 2013 (abstract OFP-13-008).

166. Zur Hausen A, Rennspiess D, Winnepenninckx V, Speel EJM, Kurz AK: Early B cell differentiation in Merkel cell carcinomas indicates cellular ancestry. 23. Deutscher

71

Hautkrebskongress 2013 und ADO-Jahrestagung, September 26-28, 2013, Essen, Germany. Journal der deutschen dermatologischen gesellschaft 11 (9), 904, 2013 (abstract FV11).

167. Litjens JNTM, Van de Vijver KK, Hopman AHN, Ummelen MI, Speel EJM, Sastrowijoto SH, Van Gorp T, Slangen BFM, Kruitwagen RFPM, Krüse AJ: The majority of metachronous CIN1 and CIN3 lesions are caused by different human papillomavirus genotypes, indicating that progression of CIN1 is a rare event. 18th International Meeting of the European Society of Gynaecological Oncology (ESGO), October 19-22, 2013, Liverpool, UK. Int J Gynaecol Cancer 23 (8), Suppl 1, 164, 2013.

168. Pierssens DDCG, Borgemeester M, van der heijden S, Bergshoeff VE, Haesevoets A, Ruland A, Peutz C, Kremer B, Speel EJM, kessler P:

Chromosomal instability in resection

margins of oral cavity tumors predicts (loco)regional recurrence. Annual meeting of the Dutch Society of Maxillofacial Surgery, November 7-8, 2013, Assen, The Netherlands.

169. Calon T, Roemen G, Straetmans J, Cornet I, Speel EJM, Kremer B: PIK3CA mutations occur more frequently in human papillomavirus-containing oropharyngeal carcinomas and are associated with poor survival. 223


Otorhinolaryngology and Head and Neck Surgery. Maastricht, 14-15 november. Dutch J Otolaryngol Head Neck Surg 19, 79, 2013.

170. Straetmans J, Speel EJM, Hoebers F, Kremer B: Human papilloma virus confuses the prognostic value of UICC’s TNM classification in tonsillar squamous cell carcinomas. 223

th

General Meeting of the Netherlands Society of Otorhinolaryngology and Head and Neck Surgery. Maastricht, 14-15 november. Dutch J Otolaryngol Head Neck Surg 19, 79, 2013.

171. Pierssens DDCG, Borgemeester M, Van der Heijden S, Peutz C, Speel EJM, Kremer B: Chromosomal instability in resection margins of oral cancer predicts (loco)regional recurrences. 223

th General Meeting of the Netherlands Society of Otorhinolaryngology and

Head and Neck Surgery. Maastricht, 14-15 november. Dutch J Otolaryngol Head Neck Surg 19, 79, 2013.

172. Haugg AM, Speel EJM, zur Hausen A, Rennspiess D, Cathomas G, Becker JC, Schrama D: VP1 expression in Merkel cell polyomavirus (MCPyV) positive Merkel cell carcinomas (MCC) is linked to specific Fluorescence in situ hybridisation (FISH) pattern and high viral load. 7th International Conference HPV, Polyomavirus, UV in skin cancer, April 9-12, 2014, Novara, Italy.

173. Melchers LJ, Mastik MF, Samaniego-Cameron B, van Dijk BA, de Bock GH, van der Laan BF, van der Vegt B, Speel EJM, Roodenburg JL, Witj MJ: Detection of HPV-associated oropharyngeal tumors in a 16-year cohort: more than meets the eye. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA. JAMA Otolaryngology-Head and Neck Surgery 2014 (abstract S134) (ahns.jnabstracts.com).

174. Cornet I, Kremer B, Calon T, Roemen GM, Straetmans JMJAA, Speel EJM: PIK3CA mutations occur more frequently in human papillomavirus-containing oropharyngeal carcinomas and are associated with poor overall survival. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA. JAMA Otolaryngology-Head and Neck Surgery 2014 (abstract S136) (ahns.jnabstracts.com).

175. Bergshoeff VE, Balkenhol MC, Chenault, Nap M, Haesevoets A, Ruland A, Nelissen RC, Takes R, Van der Laak JA, Slootweg PJ, Ramaekers FCS, Kremer B, Speel EJM: Objective evaluation criteria for chromosome instability detection by FISH to predict malignant progression in premalignant laryngeal lesions. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA. JAMA Otolaryngology-Head and Neck Surgery 2014 (abstract S197) (ahns.jnabstracts.com).

176. Pierssens DDCG, van der Heijden S, Kessler P, Bergshoeff VE, Ruland A, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of oral cancers is a predictor of local recurrence. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA. JAMA Otolaryngology-Head and Neck Surgery 2014 (abstract S206) (ahns.jnabstracts.com).

177. Hoebers F, Rios Velazquez E, Aerts HJWL, Rietbergen MM, Brakenhoff RH, Speel EJM, Straetmans JMJAA, Kremer B, Lambin P: Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than

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TNM staging. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA. JAMA Otolaryngology-Head and Neck Surgery 2014 (abstract S230) (ahns.jnabstracts.com).

178. Speel EJM, Straetmans J, Stuut M, Hoebers F, Lacko M, Kremer B: Human papilloma virus reduces the prognostic value of UICC's TNM classification in tonsillar squamous cell cacinomas (SCC). 26th European Congress of Pathology, August 30-September 3, 2014, London, UK. Virchows Arch 465 (Suppl 1), S35, 2014 (abstract OPF-12-011).

179. Speel EJM, Swarts D, Van Suylen RJ, Den Bakker M, Van Oosterhout M, Thunnissen F, Volante M, Dingemans AM, Ramaekers FCS: Interobserver variability for the WHO classification of pulmonary carcinoids. 26th European Congress of Pathology, August 30-September 3, 2014, London, UK. Virchows Arch 465 (Suppl 1), S46-47, 2014 (abstract OPF-16-007).

180. Hillen LM, Kamsteeg EJ, Schoots J, Tiebosch A, Speel EJM, Roemen GM, Peutz-Koostra CJ, Stumpel CTRM:

Congenital nephrotic syndrome: not always the Finnish type!. 25th

European Meeting on Dysmorphology, September 10-12, 2014, Le Bischenberg, France. 181. Cornet I, Kremer B, Kok G, Speel EJM: Effectivity of cidofovir treatment on human

papillomavirus-positive and –negative head and neck carcinoma cell lines in vitro. 225th

General Meeting of the Netherlands Society of Otorhinolaryngology and Head and Neck Surgery. Nieuwegein, 20-21 November. Dutch J Otolaryngol Head Neck Surg 20, 2014.

182. Speel EJM, Kremer B, Huebbers CU, Klussmann JP, Reuschenbach M, von Knebel Doeberitz M: Methylation status of HPV16 E2 binding sites classifies HPV-positive oropharyngeal carcinomas in different subtypes. 22 5

th General Meeting of the Netherlands

Society of Otorhinolaryngology and Head and Neck Surgery. Nieuwegein, 20-21 November. Dutch J Otolaryngol Head Neck Surg 20, 2014.

183. Derks JL, Dingemans AMC, Van Suylen RJ, Thunnissen E, Den Bakker MA, PALGA: Dutch Pathology Registry, Speel EJM: A national pathology registration analysis of applied terminology in pulmonary neuroendocrine tumors/carcinomas, is the WHO 2004 classification in line with clinical practice? Pathology Days, April 22-24, 2015, Zeist, The Netherlands.

184. Verhees F, Cornet I, Hoebers F, Hoeben A, Speel EJM, Kremer B: The PIK3CA-inhibitor BYL719 is an effective growth inhibitor in head and neck squamous cell carcinoma cell lines, independent of HPV status. 226


Otorhinolaryngology and Head and Neck Surgery, April 23-24, 2015, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 21, 2015.

185. Cornet I, Kremer B, Kok G, Speel EJM: Efficacy of cidofovir treatment on human papillomavirus-positive and -negative head and neck squamous cell carcinoma cell line in vitro. 86th Annual Meeting of the German Society of Otorhinolaryngology and Head and Neck Surgery, May 13-16, 2015, Berlin, Germany.

186. Speel EJM, Swarts DRA, Rudelius M, Claessen SMH, Cleutjens JP, Volante M, Klöppel G, Ramaekers FCS: Impact of Ki-67 proliferative index on survival in patients with typical and atypical pulmonary carcinoids. 27th European Congress of Pathology, September 5-9, 2015, Belgrade, SRB. Virchows Arch 467, Suppl 1, S17, 2015 (abstract OFP-05-009).

187. Speel EJM, Pierssens DDCG, Borgemeester MC, Van der Heijden S, Bergshoeff VE, Peutz-Kootstra CJ, Ruland A, Haesevoets A, Kessler P, Kremer B: Chromosome instability in tumor resection margins of oral cancers is a predictor of local recurrence. 27th European Congress of Pathology, September 5-9, 2015, Belgrade, SRB. Virchows Arch 467, Suppl 1, S25-S26, 2015 (abstract OFP-09-009).

188. Letovanec I, Peters S, Tsourti Z, Finn SP, Soltermann A, Bubendorf L, Speel EJM, Marchetti A, Nonaka D, Hager H, Martorell M, Monkhorst K, Sejda A, Cheney R, Sansano I, Verbeken EK, Tischler V, Savic S, Di Lorito A, Consuelo Calabuig M, Felip E, Adjei A, Warth A, Baas P, Meldgaard P, Blackhall F, Dingemans AMC, Dienemann H, Dziadziuszko R, Vansteenkiste J, Kammler R, Dafni U, Kerr K, Thunnissen E, Stahel R: Evaluation of RT-PCR methodology for ALK assessment in patients with NSCLC in Europe: Results from the ETOP Lungscape Project. 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA. J Thorac Oncol 10, Suppl 2, S693-694, 2015 (abstract P3.04-009).

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189. Bubendorf L, Dafni U, Finn SP, Warth A, Savic S, Thunnissen E, Sejda A, Verbeken EK, Tischler V, Marchetti A, Sansano I, Speel EJM, Cheney R, Nonaka D, Monkhorst K, Di Lorito A, Consuelo Calabuig M, Reidy M, Hager H, Mathieson W, Martorell M, Baas P, Dienemann H, Smit E, Blackhall F, Dingemans AMC, Felip E, Adjei A, Meldgaard P, Weder W, Vansteenkiste J, Dziadziuszko R, Tsourti Z, Kerr K, Schulze K, Das-Gupta A, Peters S, Stahel R: Prevalence and clinical association of MET gene amplification in patients with NSCLC: Results from the ETOP Lungscape Project. 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA. J Thorac Oncol 10, Suppl 2, S247, 2015 (abstract ORAL37.05).

190. Keijzers M, Dingemans AMC, Rennspies D, Pujari S, Abdul Hamid MH, Hochstenbag M, Speel EJM, Haugg A, Buck C, De Baets M, Zur Hausen A: Detection of Human Polyomavirus 7 in thymomas. 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA (abstract MO03.09).

191. Kerr KM, Thunnissen E, Blackhall F, Dafni U, Bubendorf L, Hager H, Soltermann A, O'Byrne K, Marchetti A, Dooms C, Sejda A, Sasano I, Nonaka D, Cheney R, De Jong J, Speel EJM, Jantus-Lewintre E, Zhang YJ, Stahel R, Peters S: ALK immunohistochemistry and fluorescence in-situ hybridization in Lung adenocarcinomas from the ETOP Lungscape tumour cohort. 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA (abstract MO10.07).

192. Kerr K, Dafni U, Schulze K, Thunnissen E, Bubendorf L, Hager H, Gately K, Biernat W, Vliegen L, Hernandez Losa J, Marchetti A, Cheney R, Warth A, Speel EJM, Blackhall F, Molina MA, Shames DS, Peters S, Stahel R, On behalf of the ETOP Lungscape investigators: Prevalence and clinical association of gene mutations through Multiplex Mutation Testing in patients with NSCLC: Results from the ETOP Lungscape Project. 18th ECCO-40th ESMO European Cancer Congress, September 25-29, 2015, Vienna, AU. Eur J Cancer 51, Suppl 3, S595, 2015 (abstract 3001).

193. Derks JL, Van Suylen RJ, Thunnissen E, Den Bakker M, Smit EF, Groen HJM, PALGA: Dutch Pathology Registry, Speel EJM#, Dingemans AMC: A population based pathology analysis on application of WHO-nomenclature in pulmonary neuroendocrine tumors. 8th Annual meeting of the NANETS, October 14-18, 2015, Austin, Tx, USA. Pancreas 45, 474, 2016.

194. Derks JL, Hendriks LE, Buikhuisen WA, Groen HJM, Thunnissen E, Van Suylen RJ, Houben R, Damhuis RA, Speel EJM, Dingemans AMC: Clinical features of large cell neuroendocrine carcinoma: a population based overview. 8th Annual meeting of the NANETS, October 14-18, 2015, Austin, Tx, USA. Pancreas 45, 474-475, 2016.

195. Roemen GM, Hillen LM, Kamsteeg EJ, Schoots J, Tiebosch A, Speel EJM, Peutz-Koostra CJ, Stumpel CTRM: An uncommon WT1 mutation and XY-genotype detected in 22 year old FFPE tissue of a case of congenital nephrotic syndrome caused by Denys-Drash syndrome. AMP 2015 Annual Meeting, November 5-7, 2015, Austin, TX, USA.

196. Van Dijk W, De Koning B, Van de Vos M, Castelein S, Helderman-van den Enden ATJM, Krapels IPC, Speel EJM, Paulussen ADC, Van Tienen FH, Holschen A, Van den Wijngaard A: Cardiomyopathy NGS gene panel analysis on DNA from paraffin material. 20 years of Cardiogenetics in the Netherlands, December 4, 2015, Amsterdam, The Netherlands.

197. Verhees F, Koenen LW, Hoebers F, Hoeben A, Kremer B, Speel EJM: De PIK3CA-inhibitor BKM120 is een effectieve groei inhibitor in hoofd/hals plaveiselcelcarcinoom cellijnen, onafhankelijk van de HPV status. 228


Otorhinolaryngology and Head and Neck Surgery. April 20-21, 2016, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 22, 2016.

198. Speel EJM: Molecular diagnostics in oncopathology in the Netherlands: state of the art and future perspectives. 14th National symposium of microscopic morphology with international participation. May 5, 2016, Tirgu Mures, Romania

199. Bulthuis VJ, Damen PJJ, Hanssens PEJ, Lie ST, Speel EJM, van Overbeeke JJ: 1p36 loss is associated with regrowth of WHO grade I meningiomas after Gamma Knife radiosurgery. 18th Leksell Gamma Knife Society Meeting, May 15-19, 2016, Amsterdam, The Netherlands.

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200. Speel EJM, Olthof NC, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Drebber U, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU:

Differential expression of Aldo-Keto-Reductase 1C1 and 1C3 genes is associated with viral physical status in HPV16 positive OSCC. AHNS 9th International Conferemce on head and neck cancer, July 16-20, 2016, Seattle, USA (abstract S278) JAMA Otolaryngology-Head and Neck Surgery 2016 (ahns.jnabstracts.com).

201. Pierssens DDCG, Borgemeester MC, Van der Heijden S, Bergshoeff VE, Peutz-Kootstra C, Ruland A, Haesevoets A, Kessler P, Kremer B, Speel EJM: Chromosome instability in tumor resection margins of primary OSCC is a predictor of local recurrence. 23rd Congress of the European Association for Cranio Maxillo-Facial Surgery, September 13-16, 2016, London, UK.

202. Derks JL, van Suylen RJ, Thunnissen E, Den Bakker MA, Groen H, Smit EF, Damhuis RA, Speel EJM#, Dingemans AMC: A population based analysis of outcome of chemotherapy for metastatic pulmonary large cell neuroendocrine carcinomas: does the regimen matter? ESMO 2016 Congress, October 7-11, 2016, Copenhagen, Denmark (abstract 426PD). Ann Oncol 27, Suppl 6, 2016.

203. Chteinberg E, Schiffelers L, Sauer C, Eben J, Rennspiess D, Winnepenninckx V, Kurz AK, Speel EJM, Zenke M, zur Hausen A: No REST in Merkel Cell carcinoma. 8th International Congress on HPV & Polyomavirus in skin cancer, November 16-18, 2016, Maastricht, The Netherlands.

204. Finn S, Letovanec I, Zygoura P, Smyth P, Soltermann A, Bubendorf L, Speel EJM, Marchetti A, Nonaka D, Monkhorst K, Hager H, Martorell M, Sejda A, Cheney R, Hernandez-Losa J, Verbeken E, Weder W, Savic S, Di Lorito A, Navarro A, Felip E, Warth A, Baas P, Meldgaard P, Blackhall F, Dingemans AM, Dienemann H, Dziadziuszko R, Vansteenkiste J, O'Brien C, Geiger T, Sherlock J, Schageman J, Dafni U, Kammler R, Kerr K, Thunnissen E, Stahel R, Peters S, European Thoracic Oncology Platform Lungscape Consortium: Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project. 17th WCLC Congress, December 4-7, 2016, Vienna, Austria (abstract P1.02-025). J Thorac Oncol 12, Suppl, S501-S502, 2017.

205. Henfling M, Versleijen-Jonkers Y, Starke A, Riedl R, Sprij-Mooij D, Schmitt AM, Perren A, Ramaekers F, Hofland L, Speel EJM: The Expression of IGF Signaling Pathway Genes Is Frequently Elevated in Pancreatic Neuroendocrine Tumors, but Is Downregulated in Metastases. 14th Annual ENETS Conference, March 8-10, 2017, Barcelona, Spain. Neuroendocrinology 105, 7, Suppl 1, 2017.

206. Speel EJM, Kremer B, Haesevoets A, Illmarinen T, Auvinen E, Aaltonen LM: Prevalentie van hoog-risico humaan papillomavirus infectie en genmutaties in niet-maligne tonsillen. 230

th General Meeting of the Netherlands Society of Otorhinolaryngology and Head and

Neck Surgery. April 20-21, 2017, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 23, 2017.

207. Speel EJM, Huebbers CU, Olthof NC, Lam WL, Klussmann JP, Kremer B: De expressie van Aldo-Keto-Reductase 1C1 en 1C3 genen verschilt afhankelijk van de virale fysische status in HPV16-positieve OPSCC. 230


Otorhinolaryngology and Head and Neck Surgery. April 20-21, 2017, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 23, 2017.

208. Chteinberg E, Sauer C, Schiffelers L, Eben J, Rennspiess D, Winnepenninckx V, Speel EJM, Kurz AK, Zenke M, Hausen AZ: Merkel cell carcinomas are RESTless. 13th Congress of the EADO, May 3-6, 2017, Athens, Greece (abstract FC1.3). J Eur Acad Dermatol Venerol 31, 34-35, Suppl 3.

209. Thunnissen E, Dafni U, Bubendorf L, Finn S, Soltermann A, Biernat W, Cheney R, Verbeken E, Warth A, Marchetti A, Speel EJM, Pokharel S, Quinn AM, Monkhorst K, Navarro A, Polydoropoulou V, Geiger T, Kammler R, Peters S, Kerr K, Stahel R:

External

quality assessment of PD-L1 expression scoring based on tissue microarrays and cross-validation with whole sections method, in patients with resected, stage I-III, non-small cell lung cancer: The ETOP Lungscape project. 29th ECP congress, September 2-6, 2017,

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Amsterdam, The Netherlands (abstract OFP-12-009). Virchows Archiv 471, S37-S38, Suppl 1, 2017.

210. Derks J, Leblay N, van Suylen RJ, Thunnissen E, den Bakker MA, Groen HJM, Smit E, Damhuis RA, van den Broek E, Charbrier A, Foll M, McKay J, Fernandez-Cuesta L, Speel EJM#, Dingemans AM:

Genomic subtypes of pulmonary large cell neuroendocrine

carcinoma (LCNEC) may predict chemotherapy outcome. ESMO 2017 Congress, September 8-12, 2017, Madrid, Spain (abstract 4310). Annal Oncol 28, Suppl 5, 2017.

211. Kerr KM, Thunnissen E, Dafni U, Soltermann A, Finn S, Bubendorf L, Verbeken E, Biernat W, Warth A, Marchetti A, Speel EJM, Pokharel S, Quinn AM, Monkhorst K, Navarro A, Polydoropoulou V, Kammler R, Peters S, Stahel RA, Consortium OBLungscape: Association of programmed cell death 1 ligand (PD-L1) expression with molecular alterations in non-small cell lung cancer (NSCLC) patients (pts): Results from the European Thoracic Oncology Platform (ETOP) Lungscape cohort. ESMO 2017 Congress, September 8-12, Madrid, Spain (abstract 1630PD). Annal Oncol 28, Suppl 5, 2017.

212. Verhees F, Jacobs R, Cornet I, Kremer B, Speel EJM: Het antivirale middel Cidofovir remt de groei van HPV-positieve en –negatieve hoofd-hals plaveiselcelcarcinoom cellijnen onder andere door DNA-schade te veroorzaken. 231

th General Meeting of the Netherlands

Society of Otorhinolaryngology and Head and Neck Surgery. November 16-17, 2017, Nieuwegein, The Netherlands. Dutch J Otolaryngol Head Neck Surg 23, 2017.

213. Huebbers CU, Verhees F, Poluschkin L, Olthof NC, Kolligs J, Siefer OG, Henfling M, Ramaekers FCS, Preuss SF, Beutner D, Seehawer J, Drebber U, Lam WL, Vucic EA, Kremer B, Klussmann JP, Speel EJM: Upregulation of Aldo-Keto-Reductase 1C1 and 1C3 is associated with 13 poor prognosis in OPSCC independent of HPV status. 2nd International Symposium on Tumor-Host Interaction in Head and Neck Cancer. 3rd International Symposium on HPV Infection in Head and Neck Cancer. January 25-27, 2018, Essen, Germany (abstract 14).

214. Verhees F, Legemaate D, Jacobs R, Rousch M, Kremer B, Speel EJM: Efficacy of the antiviral agent Cidofovir to inhibit the growth of HPV-48 positive and -negative head and neck squamous cell carcinomas in vitro and the role of DNA-damage. 2nd International Symposium on Tumor-Host Interaction in Head and Neck Cancer. 3rd International Symposium on HPV Infection in Head and Neck Cancer. January 25-27, 2018, Essen, Germany (abstract 48).

18. Poster presentations at scientific congresses based on submitted abstracts 1. Speel EJM, Schutte B, Ramaekers FCS, Hopman AHN: Application of the alkaline

phosphatase/fast red immunodetection system for in situ hybridization fluorescence confocal microscopy. XV Congress of the International Society for Analytical Cytology, August 25-30, Bergen, Norway. Cytometry, Suppl 5, 133-134, 1991 (abstract 723A).

2. Speel EJM, Schutte B, Wiegant J, Ramaekers FCS, Hopman AHN: A novel detection system for fluorescence in situ hybridization based on the alkaline phosphatase-fast red reaction. 2

nd Conference of the European Society for Analytical Cellular Pathology, May 17-

22, 1992, Nijmegen, The Netherlands. Anal Cell Pathol 4, 230-231, 1992 (abstract 354). 3. Speel EJM, Kamps M, Bonnet J, Ramaekers FCS, Hopman AHN: Multicolor preparations

for in situ hybridization using precipitating enzyme cytochemistry in combination with reflection contrast microscopy. 7

th Annual Workshop on Recent Advances in Molecular Pathology, June

17-20, 1992, Boston, USA. 4. Speel EJM, Kamps M, Bonnet J, Ramaekers FCS, Hopman AHN: In situ hybridization based

on reflection of different enzyme cytochemical reaction products. 9th International Congress of

Histochemistry and Cytochemistry, August 30-September 5, 1992, Maastricht, The Netherlands. Histochemical Journal 24, 560, 1992 (abstract P13.23).

5. Speel EJM, Schutte B, Wiegant J, Ramaekers FCS, Hopman AHN: Application of the alkaline phosphatase-fast red reaction to fluorescence in situ hybridization: high sensitivity and suitable bleaching properties. 9

th International Congress of Histochemistry and

Cytochemistry, August 30-September 5, 1992, Maastricht, The Netherlands. Histochemical Journal 24, 562, 1992 (abstract P13.30).

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6. Speel EJM, Kamps M, Bonnet J, Ramaekers FCS, Hopman AHN: In situ hybridization based on reflection of different enzyme cytochemical reaction products. XVI Congress of the International Society for Analytical Cytology, March 21-26, 1993, Colorado Springs, USA. Cytometry, Suppl 6, 1993 (abstract 472L).

7. Speel EJM, Kamps M, Bonnet J, Ramaekers FCS, Hopman AHN: In situ hybridization based on reflection of different enzyme cytochemical reaction products. Joint Meeting German and Dutch Societies for Cell Biology, March 28-April 1, 1993, Münster, Germany. Eur J Cell Biol 60, Suppl 37, 107, 1993 (abstract 311).

8. Speel EJM, Herbergs J, Lawson D, Gosden J, Ramaekers FCS, Hopman AHN: Alkaline phosphatase-fast red immunocytochemistry combined with PRINS, FISH and BrdU labeling in multiparameter detection procedures. XVII Congress of the International Society for Analytical Cytology, October 16-21, 1994, Lake Placid, USA. Cytometry, Suppl 7, 82, 1994 (abstract 469A).

9. Speel EJM, Jansen M, Lawson D, Gosden J, Ramaekers FCS, Hopman AHN: Brightfield microscopical detection procedure for triple-target in situ hybridization and PRINS, which can be combined with immunocytochemistry. XVII Congress of the International Society for Analytical Cytology, October 16-21, 1994, Lake Placid, USA. Cytometry, Suppl 7, 83, 1994 (abstract 470B).

10. Herbergs J, Speel EJM, De Bruïne A, Arends JW, Ramaekers FCS, Hopman AHN: Genetic heterogeneity in colonic carcinomas, adjacent adenomas and normal mucosa as detected with in situ hybridization. XVII Congress of the International Society for Analytical Cytology, October 16-21, 1994, Lake Placid, USA. Cytometry, Suppl 7, 92, 1994 (abstract 535C).

11. Hopman AHN, Speel EJM, Arends JW, Ramaekers FCS: Analysis of chromosome copy numbers in thin tissue sections of tumor cell areas with high nuclear density. XVIII Congress of the International Society for Analytical Cytology, 1996, Rimini, Italy. Cytometry, Suppl 8, 90, 1996 (abstract IH106).

12. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Brightfield detection of oligonucleotide primed in situ (PRINS) labeled DNA in cell preparations and frozen tissue sections. XVIII Congress of the International Society for Analytical Cytology, 1996, Rimini, Italy. Cytometry, Suppl 8, 107, 1996 (abstract AC42).

13. Speel EJM, Ramaekers FCS, Hopman AHN: Sensitive mutiple-target in situ hybridization using combined peroxidase-mediated depositions of differently haptenized tyramides. XVIII Congress of the International Society for Analytical Cytology, 1996, Rimini, Italy. Cytometry, Suppl 8, 107, 1996 (abstract AC43).

14. Speel EJM, Van Gansewinkel A, Ramaekers FCS, Hopman AHN: Interchromosomal localization of ribosomal RNA within the interphase nucleus. 11

th European Cytoskeleton

Forum, August 31-September 4, 1996, Maastricht, The Netherlands. 15. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Brightfield detection

of oligonucleotide primed in situ (PRINS) labeled DNA in cell preparations and frozen tissue sections. Symposium Oncology in Maastricht, January 16, 1997, Maastricht, The Netherlands.

16. Speel EJM, Lawson D, Ramaekers FCS, Gosden JR, Hopman AHN: Brightfield detection of oligonucleotide primed in situ (PRINS) labeled DNA in cell preparations and frozen tissue sections. 4

th Euregional Oncology Meeting, January 17, 1997, Maastricht, The Netherlands.

17. Speel EJM, Nyabi O, Herens C, Ramaekers FCS, Hopman AHN, Koulischer L: Applications of the catalyzed reporter deposition system for sensitive in situ hybridization on metaphase chromosomes and interphase cells. 4

th Euregional Oncology Meeting,

January 17, 1997, Maastricht, The Netherlands. 18. Hopman AHN, Kamps M, Dederen J, Speel EJM, Ramaekers FCS: Bicolor ISH using

CARD amplification for the rapid and efficient analysis of chromosomal imbalances in cancer. ISAC XIX International Congress, February 28-March 5, 1998, Colorado Springs, USA. Cytometry, Suppl 9, 146-147, 1998 (abstract GE 04).

19. Speel EJM, Görtz B, Roth J, Krähenmann A, De Krijger RR, Muletta-Feurer S, Rütimann K, Saremaslani P, Heitz PU, Komminoth P: Mutations of the MEN1 gene in sporadic

77

adrenocortical lesions. 6th European Conference on Cytogenetics and Molecular Genetics

of human solid tumors, October 15-18, 1998, Saarbrücken, Germany (abstract P93). 20. Speel EJM, Richter J, Moch H, Egenter C, Zhao J, Saremaslani P, Rütimann K, Barghorn

A, Roth J, Heitz PU, Komminoth P: Marked genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization. 90


American Association for Cancer Research, April 10-14, 1999, Philadelphia, USA. Proceedings AACR 40, 537, 1999 (abstract 3542).

21. Zhao J, Komminoth P, Speel EJM, Muletta-Feurer S, Rütimann K, Saremaslani P, Roth J, Heitz PU, Speel EJM: Genomic alterations in adrenocortical lesions detected by comparative genomic hybridization. 90

th Annual Meeting of the American Association for

Cancer Research, April 10-14, 1999, Philadelphia, USA. Proceedings AACR 40, 537, 1999 (abstract 3543).

22. Speel EJM, Meier D, Matter C, Muletta-Feurer S, Van Asseldonk M, Roth J, Heitz PU, Komminoth P: Chromosome 11q losses in sporadic endocrine pancreatic tumors: another tumor suppressor gene telomeric of MEN1? 17

th European Congress of Pathology,

September 18-23, 1999, Barcelona, Spain. Virchows Archiv 435, 219, 1999 (abstract P-105).

23. Bode-Lesniewska B, Zhao J, Speel EJM, Biraima AM, Turina M, Heitz PU, Komminoth P: Intimal sarcomas of the pulmonary artery. 17

th European Congress of Pathology,

September 18-23, 1999, Barcelona, Spain. Virchows Archiv 435, 315, 1999 (abstract P-492).

24. Dannenberg H, Zhao J, Speel EJM, Saremaslani P, Roth J, Heitz PU, Dinjens WNM, Oosterhuis JW, De Krijger RR, Komminoth P: Comparative genomic hybridization analysis of pheochromocytomas and extra-adrenal paragangliomas reveals frequent losses of chromosome 1p, 3q and 11. 65. Jahresversammlung der Schweizerischen Gesellschaft für Pathologie, November 4-6,1999, Aarau, Switzerland. Schweiz Med Wochenschr 129, 1428, 1999 (abstract 29).

25. Zhao J, De Krijger RR, Speel EJM, Muletta-Feurer S, Matter C, Saremaslani P, Roth J, Heitz PU, Komminoth P: Genomic alterations in gastrointestinal and bronchial neuroendocrine tumors (Carcinoids): marked differences indicating diversity in molecular pathogenesis. 65. Jahresversammlung der Schweizerischen Gesellschaft für Pathologie, November 4-6,1999, Aarau, Switzerland. Schweiz Med Wochenschr 129, 1428, 1999 (abstract 30).

26. Dannenberg H, Zhao J, Speel EJM, Saremaslani P, Roth J, Heitz PU, Dinjens WNM, Mooi WJ, De Krijger RR, Komminoth P: Genetic alterations in pheochromocytomas and paragangliomas. Annual Meeting of the United States and Canadian Academy of Pathology, March 25-31, 2000, New Orleans, USA. Lab Invest 80, 71A, 2000 (abstract 404).

27. Perren A, Saremaslani P, Matter C, Muletta S, Lees JA, Heitz PU, Speel EJM, Komminoth P, Eng C: PTEN expression study in endocrine pancreatic tumors. Annual Meeting of the United States and Canadian Academy of Pathology, March 25-31, 2000, New Orleans, USA. Lab Invest 80, 74A, 2000 (abstract 419).

28. Speel EJM, Scheidweiler AF, Saremaslani P, Rütimann K, Zhao J, Volante M, Roth J, Heitz PU, Komminoth P: Genetic alterations in human insulinomas: a comparative genomic hybridization study. Annual Meeting of the United States and Canadian Academy of Pathology, March 25-31, 2000, New Orleans, USA. Lab Invest 80, 74A, 2000 (abstract 420).

29. Speel EJM, Scheidweiler AF, Zhao J, Saremaslani P, Roth J, Heitz PU, Komminoth P: Different genomic alterations in small (D ≤ 2 cm) functioning and non-functioning endocrine pancreatic tumors. 91

st Annual Meeting of the American Association for Cancer Research,

April 1-5, 2000, San Francisco, USA. Proceedings AACR 41, 419-420, 2000 (abstract 2669).

30. Dannenberg H, Speel EJM, Zhao J, Saremaslani P, Roth J, Heitz PU, Dinjens WNM, Mooi WJ, De Krijger RR, Komminoth P: Genomic alterations in pheochromocytomas: losses of chromosomes 1p and 3q are early events in tumorigenesis. 91

st Annual Meeting of the

78

American Association for Cancer Research, April 1-5, 2000, San Francisco, USA. Proceedings AACR 41, 513, 2000 (abstract 3269).

31. Labuhn M, Jones G, Speel EJM, Maier D, Gratzl O, Merlo A: Precize assessment of homozygous deletions at the INK4A/ARF locus in primary glioblastomas by quantitative real-time Taqman PCR. 91

st Annual Meeting of the American Association for Cancer

Research, April 1-5, 2000, San Francisco, USA. Proceedings AACR 41, 856, 2000 (abstract 5439).

32. Hopman AHN, Speel EJM, Ummelen M, Smedts F, Ramaekers FCS: Highly sensitive detection of human papillomvirus in cervical CIN lesions, microinvasive and invasive carcinoma. XI

th International Congress of Histochemistry and Cytochemistry, September 3-

8, 2000, York, UK. Proc. Roy Micr Soc, 101, 2000 (abstract K15). 33. Speel EJM, Kamps M, Schapers RFM, Ramaekers FCS, Hopman AHN: Genetic analysis

of urothelial carcinoma in situ with FISH for chromosomes 1, 7 and 9: its impact on understanding bladder cancer development. XI

th International Congress of Histochemistry

and Cytochemistry, September 3-8, 2000, York, UK. Proc. Roy Micr Soc, 101, 2000 (abstract K16).

34. Schaart G, Speel EJM, Ummelen M, Ramaekers FCS, Hopman AHN: Sensitive multiple-target fluorescence detection systems for immunocytochemistry and in situ hybridization using tyramide signal amplification. XI

th International Congress of Histochemistry and

Cytochemistry, September 3-8, 2000, York, UK. Proc. Roy Micr Soc, 112, 2000 (abstract Q2).

35. Speel EJM, Van der Toorn PPG, Veltman JA, Bot FJ, De Jong JMA, Manni JJ, Ramaekers FCS, Hopman AHN: Mapping of resection margins of oral cancer for p53 overexpression and chromosome instability to detect residual (pre)malignant cells. 7

th European Workshop

on Cytogenetics and Molecular Genetics of Human Solid Tumors, September 7-9, 2000, Edinburgh, UK (abstract P39).

36. Speel EJM, Kamps M, Schapers RFM, Sauter G, Ramaekers FCS, Hopman AHN: Genetic analysis of urothelial carcinoma in situ with FISH for chromosomes 1, 7 and 9: its impact on understanding bladder cancer development. 7

th European Workshop on Cytogenetics and

Molecular Genetics of Human Solid Tumors, September 7-9, 2000, Edinburgh, UK (abstract P91).

37. Speel EJM, Claessen SMH, Van Mierlo A, Haesevoets A, Hopman AHN, Ramaekers FCS, Loosen I, Arends J-W, Van de Wouw AJ, Joosten S, Griffioen A, Hillen HFP: Genetic characterization of different distant metastases in patients with cancers of unknown primary tumor. 92

nd Annual Meeting of the American Association for Cancer Research, March 24-

28, 2001, New Orleans, USA. Proceedings AACR 42, 194, 2001 (abstract 1042). 38. Speel EJM, Barghorn A, Farspour B, Schmid S, Saremaslani P, Perren A, Roth J, Heitz

PU, Komminoth P: A putative tumor suppressor locus at 6q22 is involved in the malignant outgrowth of endocrine pancreatic tumors. 92

nd Annual Meeting of the American

Association for Cancer Research, March 24-28, 2001, New Orleans, USA. Proceedings AACR 42, 631, 2001 (abstract 3390).

39. Zhao J, Moch H, Scheidweiler AF, Baer A, Schäffer AA, Sauter G, Speel EJM, Roth J, Heitz PU, Komminoth P: Comparison of genomic changes in primary endocrine pancreatic tumors and their metastases. 92

nd Annual Meeting of the American Association for Cancer

Research, March 24-28, 2001, New Orleans, USA. Proceedings AACR 42, 791, 2001 (abstract 4243).

40. Hopman AHN, Kamps M, Schapers RFM, Speel EJM, Sauter G, Ramaekers FCS,: Genetic analysis of urothelial carcinoma in situ with FISH for chromosomes 1, 7 and 9: its impact on understanding bladder cancer development. 8

th Euregional Oncology Meeting,

April 19, 2001, Maastricht, The Netherlands. 41. Hopman AHN, Smedts F, Ummelen M, Dignef W, Speel EJM, Ramaekers FCS: Highly

sensitive detection of human papillomvirus in cervical CIN lesions, microinvasive and invasive carcinoma. 8

th Euregional Oncology Meeting, April 19, 2001, Maastricht, The

Netherlands. 42. Hopman AHN, Kamps M, Vriezema J, Speel EJM, Schalken J, Ramaekers FCS:

Fluorescence in situ hybridization of bladder irrigation specimens for the detection of

79

urothelial carcinoma. 8th Euregional Oncology Meeting, April 19, 2001, Maastricht, The

Netherlands. 43. Zhao J, Moch H, Scheidweiler AF, Baer A, Schäffer AA, Speel EJM, Roth J, Heitz PU,

Komminoth P: Genomic imbalances in the progression of endocrine pancreatic tumors. Annual Meeting United States and Canadian Academy for Pathology, February 23-March 1, 2002, Chicago, USA. Lab Invest 82, 2P, 2002.

44. Hopman AHN, Speel EJM, Kamps M, Schapers RFM, Sauter G, Schalken J, Ramaekers FCS: Chromosome 9 changes in carcinoma in situ (CIS) of the bladder. Differential loss of 9p11-q12 and 9p21 in CIS with or without a concomitant malignant tumor. 93

rd Annual

Meeting of the American Association for Cancer Research, April 6-10, 2002, San Francisco, USA. Proceedings AACR 43, 632, 2002 (abstract 3141).

45. Speel EJM, Claessen SMH, Van Mierlo A, Haesevoets A, Hopman AHN, Ramaekers FCS, Van der Wurff AAM, Joosten S, Van de Wouw AJ, Hillen HFP: Genetic evidence for a clonal relationship between different distant metastases in patients with cancers of unknown primary. 93

rd Annual Meeting of the American Association for Cancer Research,

April 6-10, 2002, San Francisco, USA. Proceedings AACR 43, 635, 2002 (abstract 3153). 46. Speel EJM, Meier D, Zhao J, Matter C, Muletta-Feurer S, Perren A, Saremaslani P,

Schuuring E, Roth J, Heitz PU, Komminoth P: Chromosome 11q losses in sporadic endocrine pancreatic and neuroendocrine tumors indicate the presence of another tumor suppressor gene telomeric of MEN1. 93

rd Annual Meeting of the American Association for

Cancer Research, April 6-10, 2002, San Francisco, USA. Proceedings AACR 43, 636, 2002 (abstract 3160).

47. Speel EJM, Hafkamp HC, Haesevoets A, Ramaekers FCS, Bot FJ, Manni JJ, Hopman AHN: A subset of head and neck squamous cell carcinomas that overexpresses p53 demonstrates integration of genomic HPV 16/18 DNA. 93

rd Annual Meeting of the American

Association for Cancer Research, April 6-10, 2002, San Francisco, USA. Proceedings AACR 43, 652, 2002 (abstract 3236).

48. Speel EJM, Hafkamp HC, Haesevoets A, Ramaekers FCS, Bot FJ, Hopman AHN, Manni JJ: A subset of head and neck squamous cell carcinomas that overexpresses p53 demonstrates integration of HPV 16/18 DNA as detected by FISH. XXI Congres of the International Society for Analytical Cytology, May 3-9, 2002, San Diego, USA. Cytometry, Suppl 11, 70-71, 2002 (abstract 44053).

49. Hopman AHN, Smedts F, Ummelen M, Dignef W, Speel EJM, Ramaekers FCS: Highly sensitive detection of human papillomvirus in cervical CIN lesions, microinvasive and invasive carcinoma. XXI Congres of the International Society for Analytical Cytology, May 3-9, 2002, San Diego, USA. Cytometry, Suppl 11, 71, 2002 (abstract 44083).

50. Hillen HFP, Claessen SMH, Van Mierlo A, Haesevoets A, Hopman AHN, Ramaekers FCS, Van der Wurff AAM, Joosten S, Van de Wouw AJ, Speel EJM: Genetic analysis reveals evidence for a clonal relationship between multiple tumors in individual patients with unknown primary tumor. 38

th Annual Meeting of the American Society of Clinical Oncology,

May 18-21, 2002, Orlando, USA. Proceedings ASCO 21, 453a, 2002 (abstract 1810). 51. Hopman AHN, Kamps M, Speel EJM, Schapers RFM, Sauter G, Ramaekers FCS:

Differential loss of chromosome 9p11-q12 and 9p21 in carcinoma in situ with or without concomitant malignant bladder tumors. Euregional Life Sciences Conference Cells at work, November 28, 2002, Maastricht, The Netherlands.

52. Speel EJM, Hafkamp HC, Haesevoets A, Bot FJ, Dinjens WNM, Ramaekers FCS, Hopman AHN, Manni JJ: A subset of head and neck squamous cell carcinomas exhibits integration of genomic HPV 16/18 DNA and p53 overexpression in the absence of mutations in exons 5-8. Euregional Life Sciences Conference Cells at work, November 28, 2002, Maastricht, The Netherlands.

53. Speel EJM, Claessen SMH, Giesen VA, Verhofstad AA, Cuijpers VM, Dannenberg H, De Krijger RR: Chromosomal alterations involved in the pathogenesis of sporadic and MEN2-related pheochromocytomas. Pathology Days, April 10-11, 2003, Ede, The Netherlands (abstract II-17).

54. Speel EJM, Claessen SMH, Giesen VA, Verhofstad AA, Cuijpers VM, Dannenberg H, De Krijger RR: Chromosomal alterations involved in the pathogenesis of sporadic and MEN2-

80

related pheochromocytomas. 10th Euregional Oncology Meeting, Juni 26, 2003, Maastricht,

The Netherlands. 55. Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Voogd AC, Hopman

AHN, Ramaekers FCS, Manni JJ, Speel EJM: HPV 16-associated tonsillar carcinomas show p16

INK4A overexpression and an improved prognosis. 95


American Association for Cancer Research, March 27-31, 2004, Orlando, USA. Proceedings AACR 45, 93, 2004 (abstract 409).

56. Hopman AHN, Hommelberg P, Smedts F, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Ramaekers FCS: Human telomerase RNA component (TERC) gene copy numbers, chromosomal instability and HPV integration in premalignant lesions and cancer of the uterine cervix. 95

th Annual Meeting of the American Association for Cancer Research,

March 27-31, 2004, Orlando, USA. Proceedings AACR 45, 242-243, 2004 (abstract 1065). 57. Jonkers YMH, Claessen SMH, Komminoth P, Perren A, Verhofstad AA, Hofland LJ, De

Krijger RR, Slootweg PJ, Veltman JA, Geurts van Kessel A, Ramaekers FCS, Speel EJM: Genomic alterations in benign and malignant insulinomas as revealed by conventional and array CGH. 95

th Annual Meeting of the American Association for Cancer Research, March

27-31, 2004, Orlando, USA. Proceedings AACR 45, 654, 2004 (abstract 2837). 58. Speel EJM, Claessen SMH, Giesen VA, Verhofstad AA, Cuijpers VM, Dannenberg H, De

Krijger RR: Chromosomal alterations involved in the pathogenesis of sporadic and MEN2-related pheochromocytomas. 95

th Annual Meeting of the American Association for Cancer

Research, March 27-31, 2004, Orlando, USA. Proceedings AACR 45, 656, 2004 (abstract 2845).

59. Aarts M, Dannenberg H,Henderson L-J, Lam WL, Dinjens WNM, Speel EJM, De Krijger RR: Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb BAC array spanning chromosome arm 1p. 95


American Association for Cancer Research, March 27-31, 2004, Orlando, USA. Proceedings AACR 45, 656, 2004 (abstract 2846).

60. Claessen SMH, Limpens R, Twijnstra A, Blaauw G, Janzer R, Speel EJM: Comparative genomic hybridization analysis of primary and recurrent meningiomas. Pathology Days, April 22-23, 2004, Ede, The Netherlands (abstract III-35).

61. Jonkers YMH, Claessen SMH, Komminoth P, Perren A, Slootweg PJ, Hofland LJ, De Krijger RR, Verhofstad AA, Veltman JA, Geurts van Kessel A, Ramaekers FCS, Speel EJM: Genomic alterations in benign and malignant insulinomas as revealed by conventional and array CGH. Pathology Days, April 22-23, 2004, Ede, The Netherlands (abstract III-40).

62. Speel EJM, Jonkers YMH, Claessen SMH, Perren A, Komminoth P, Ramaekers FCS: MEN1 mutations and genomic alterations in sporadic benign and malignant insulinomas. 9

th

International workshop on Multiple Endocrine Neoplasia, June 19-22, 2004, Bethesda, USA. J Int Med 255, 723, 2004 (abstract 8003).

63. Lopez-Egido JR, Claessen SMH, MacVille M, Albrechts JCM, Skogseid B, Speel EJM: Spectral karyotypic, comparative genomic and FISH analysis of the human serotonin-producing endocrine pancreatic tumor cell line BON-1. 9

th International workshop on

Multiple Endocrine Neoplasia, June 19-22, 2004, Bethesda, USA. J Int Med 255, 724, 2004 (abstract 8004).

64. Speel EJM, Klingenberg B, Hafkamp HC, Haesevoets A, Slootweg PJ, Weissenborn SJ, Klussmann JP, Manni JJ: Is p16


human papillomavirus infection in normal tonsils? Pathology Days, April 21-22, 2005, Ede, The Netherlands (abstract III-19).

65. Stavast J, Meulemans EV, Rüland AM, Peeters JHM, Teepen JLJM, Speel EJM: Microsattelite analysis of chromosome 1p and 22q markers in primary meningiomas and recurrences with progression within one patient. Pathology Days, April 21-22, 2005, Ede, The Netherlands (abstract III-20).

66. Pauwels P, Meulemans EV, Rüland AM, Janssen J, Speel EJM: MDM2 amplification in liposarcomas and lipomas: a fluorescence in situ hybridization study. Pathology Days, April 21-22, 2005, Ede, The Netherlands (abstract III-30).

81

67. Speel EJM, Hafkamp HC, Schepers M, Bot FJ, Haesevoets A, Claessen SMH, Voogd AC, Hopman AHN, Ramaekers FCS, Manni JJ: HPV 16 in relation to smoking as prognostic indicators for patients with tonsillar carcinomas. 22

nd International Papillomavirus

Conference and Clinical Workshop 2005, April 30-May 6, 2005, Vancouver, USA (abstract P-098).

68. Hopman AHN, Kamps MAF, Smedts F, Speel EJM, Herrington CS, Ramaekers FCS: The impact of different protocols on the detection of integrated HPV by means of in situ hybridization. 22

nd International Papillomavirus Conference and Clinical Workshop 2005,

April 30-May 6, 2005, Vancouver, USA (abstract P-325). 69. Speel EJM, Claessen SMH, Stavast J, Meulemans E, Blaauw G, Teepen J, Janzer R,

Twijnstra A: Genetic analysis of meningiomas reveals chromosome-specific correlations with grade and recurrence. 2

nd Quadrennial Meeting of the World Federation of

NeuroOncology, May 5-8, 2005, Edinburgh, UK. Neuro-Oncol July, 326-327, 2005. 70. Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman

JA, Speel EJM: Frequent loss of chromosome 1p and 22q loci in insulinomas. 2nd

Marie Curie Conference on arrayCGH and Molecular Cytogenetics, October 19-22, 2005, Bari, Italy. Eur J Med Genet 48, 501, 2005 (abstract P35).

71. Speel EJM, Aarts M, Dannenberg H, Claessen SMH, DeLeeuw RJ, Van Nederveen F, Verhofstad AA, Dinjens WNM, Lam WL, De Krijger RR: Conventional and 1p-specific microarray-based CGH analysis of sporadic and syndrome-related pheochromocytomas. 2

nd Marie Curie Conference on arrayCGH and Molecular Cytogenetics, October 19-22,

2005, Bari, Italy. Eur J Med Genet 48, 508, 2005 (abstract P44). 72. Speel EJM, Meulemans EV, Rüland AM, Debiec-Rychter M, Sciot R, Pauwels P: Evaluation of

MDM2 and CDK4 gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/wel-differentiated liposarcomas in paraffin-embedded material. Pathology Days, April 20, 2006, Ede, The Netherlands (abstract III-31).

73. Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman JA, Speel EJM: Novel candidate tumor suppressor gene loci on chromosomes 11q23-24 and 22q13 involved in human insulinoma tumorigenesis. Pathology Days, April 20, 2006, Ede, The Netherlands (abstract V-42).

74. Jonkers YMH, Claessen SMH, Feuth T, Geurts van Kessel A, Ramaekers FCS, Veltman JA, Speel EJM: Novel tumor suppressor gene loci on chromosomes 1p, 11q and 22q in insulinomas. 97

th Annual Meeting of the AACR, April 1-5, 2006, Washington DC, USA.

Proceedings AACR 47, 99, 2006. (abstract 423). 75. Pauwels P, Meulemans EV, Rüland AM, Debiec-Rychter M, Sciot R, Speel EJM: Evaluation of

MDM2 and CDK4 gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/wel-differentiated liposarcomas in paraffin-embedded material. 97

th

Annual Meeting of the AACR, April 1-5, 2006, Washington DC, USA. Proceedings AACR 47, 272, 2006. (abstract 1153).

76. Klingenberg B, Haesevoets A, Hafkamp HC, Manni JJ, Slootweg PJ, Weissenborn SJ, Klussmann JP, Speel EJM: Is p16


human papillomavirus infection in normal tonsils? 97th Annual Meeting of the AACR, April

1-5, 2006, Washington DC, USA. Proceedings AACR 47, 1048, 2006. (abstract 4467). 77. Klussmann JP, Reimers N, Kasper HU, Gutinas-Lichius O, Preuss SF, Weissenborn SJ,

Hoffmann KT, Speel EJM: The prognostic significance of p16 expression in oropharynx cancer is superior to HPV-DNA detection, EGFR expression and clinical markers. 97

th

Annual Meeting of the AACR, April 1-5, 2006, Washington DC, USA. Proceedings AACR 47, 1049, 2006. (abstract 4469).

78. Speel EJM, Claessen SMH, Manni JJ, Lehnen M, Weissenborn SJ, Klussmann JP: CGH analysis of oropharyngeal squamous cell carcinomas that contain or lack HPV-16. 3

rd World

Congress of the International Federation of Head & Neck Oncologic Societies, June 27-July 1, 2006, Prague, Czech Republic. Otorinolaryngologie A Foniatrie 55, Suppl 1, 229, 2006 (abstract P267).

79. Speel EJM, Klingenberg B, Haesevoets A, Hafkamp HC, Manni JJ, Slootweg PJ, Weissenborn SJ, Klussmann JP: Is p16

INK4A overexpression a reliable biomarker for

oncogenic HPV infection in normal tonsils? 3rd

World Congress of the International

82

Federation of Head & Neck Oncologic Societies, June 27-July 1, 2006, Prague, Czech Republic. Otorinolaryngologie A Foniatrie 55, Suppl 1, 229, 2006 (abstract P268).

80. Hopman AHN, Theelen W, Hommelberg P, Kamps MA, Herrington CS, Morrison LE, Speel EJM, Smedts F, Ramaekers FCS: Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC are strongly associated events in progression of uterine cervical dysplasia to invasive cancer. 23

rd International Papillomavirus Conference and

Clinical Workshop, September 1-7, 2006, Prague, Czech Republic (abstract P-052). 81. Klingenberg B, Klussmann JP, Hafkamp HC, Haesevoets A, Manni JJ, Slootweg PJ,

Weissenborn SJ, Pfister H, Speel EJM: p16INK4A

overexpression is unreliable as a biomarker for human papillomavirus in normal tonsil tissue. 23

rd International

Papillomavirus Conference and Clinical Workshop, September 1-7, 2006, Prague, Czech Republic (abstract P-342).

82. Bergshoeff VE, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers FCS, Manni JJ, Speel EJM: Chromosome instability as detected by FISH predicts progression of premalignant lesions of the larynx. Pathology Days, April 10, 2007, Ede, The Netherlands (abstract II-19).

83. Speel EJM, Bergshoeff VE, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers FCS, Manni JJ: Chromosome instability as detected by FISH predicts progression of premalignant lesions of the larynx. Annual Meeting of the AACR, April 14-18, 2007, Los Angeles, USA. Proceedings AACR 48, 32, 2007 (abstract 129).

84. Klussmann JP, Claessen SMH, Preuss SF, Lehnen M, Weissenborn SJ, Speel EJM: Comparative genomic hybridization analysis of oropharyngeal squamous cell carcinomas that contain or lack oncogenic HPV16. Annual Meeting of the AACR, April 14-18, 2007, Los Angeles, USA. Proceedings AACR 48, 463, 2007 (abstract 1944).

85. Klussmann JP, Claessen SMH, Preuss SF, Lehnen M, Weissenborn SJ, Hopman AHN, Speel EJM: Genetic differences between HPV-16-containing and –lacking oropharyngeal squamous cell carcinomas by comparative genomic hybridization. 1

st World Congress of

the International Academy of Oral Oncology, May 17-20, 2007, Amsterdam, The Netherlands. Oral Oncol 2, Suppl, 203, 2007 (abstract P241).

86. Hopman AHN, Theelen W, Herrington CS, Morrison LE, Smedts F, Ramaekers FCS, Speel EJM. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC are strongly associated events in progression of uterine cervical dysplasia to invasive cancer. 21

st European Congress of Pathology, September 8-13 2007, Istanbul,

Turkey. Virchows Archiv 451, 497, 2007 (abstract PP4-14). 87. Speel EJM, Bergshoeff VE, Haesevoets A, Bot FJ, Voogd AC, Hopman AHN, Ramaekers

FCS, Manni JJ: Chromosome instability as detected by FISH predicts progression of premalignant lesions of the larynx. GROW-School for Oncology and Developmental Biology Science Day, December 14, 2007, Maastricht, The Netherlands.

88. Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder WW, De Krijger RR, Verhofstad AAJ, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM: DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients. 5

th Annual ENETS Conference, March 6-8,

2008, Paris, France. 89. Jonkers YMH, Claessen SMH, Van den Bosch SM, Van Engeland M, Schmid S, Rudolph

T, Perren A, Ramaekers FCS, Speel EJM: Absence of MEN1 gene promotor hypermethylation in sporadic insulinomas. 5

th Annual ENETS Conference, March 6-8,

2008, Paris, France. 90. Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder WW, De

Krijger RR, Verhofstad AAJ, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM: DNA copy number status is a powerful predictor of adverse clinical outcome in endocrine pancreatic tumor patients. Pathology Days, April 22-23, 2008, Zeist, The Netherlands.

91. Petri BJ, De Krijger RR, Van Nederveen FH, Claessen SMH, Dannenberg H, Verhofstad AAJ, Dinjens WNM, Speel EJM: Genomic analysis of pheochromocytomas: identification of specific DNA copy number changes but exclusion of 6q loss in association with biological behaviour. Pathology Days, April 22-23, 2008, Zeist, The Netherlands.

83

92. Klussmann JP, Preuss SF, Weinell A, Stenner M, Semrau R, Hoffmann TK, Gunthias-Lichius O, Speel EJM: Nuclear surviving expression is associated with HPV-independent carcinogenesis and is an indicator for poor prognosis in oropharyngeal cancer. 99

th Annual

Meeting of the AACR, April 12-16, 2008, San Diego, USA. Proceedings AACR 49, 1317, 2008 (abstract 5543).

93. Mooren JJ, Hafkamp HC, Claessen SMH, Klingenberg B, Ramaekers FCS, Voogd AC, Bot FJ, Klussmann JP, Hopman AHN, Manni JJ, Kremer B, Speel EJM: P21

Cip1/WAF1 expression

is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. 99th

Annual Meeting of the AACR, April 12-16, 2008, San Diego, USA. Proceedings AACR 49, 1317, 2008 (abstract 5544).

94. Bergshoeff VE, Hopman AHN, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM:

Chromosome instability in tumor resection margins of oral cancers is a predictor of (loco)regional recurrence. 99

th Annual Meeting of the AACR, April 12-16, 2008, San Diego,

USA. Proceedings AACR 49, 1318, 2008 (abstract 5546). 95. Jonkers YMH, Claessen SMH, Perren A, Schmitt AM, Hofland LJ, De Herder WW, De

Krijger RR, Verhofstad AAJ, Hermus AR, Kummer JA, Skogseid B, Volante M, Voogd AC, Ramaekers FCS, Speel EJM: DNA copy number status is an efficient predictor of adverse clinical outcome in endocrine pancreatic tumor patients. 99

th Annual Meeting of the AACR,

April 12-16, 2008, San Diego, USA. Proceedings AACR 49, 1321-1322, 2008 (abstract 5561).

96. Speel EJM, Claessen SMH, Van Koetsveld PM, De Krijger RR, De Herder WW, Hofland LJ: Copy number and expression analysis of the p16

INK4A and interferon β genes in

adrenocortical lesions. 6th Annual ENETS Conference, March 5-7, 2009, Granada, Spain.

Neuroendocrinology 90, 135, 2009 (abstract 91). 97. Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, Seldenrijk

KA, De Krijger RR, Slootweg PJ, Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. 6

th Annual ENETS Conference, March 5-7, 2009, Granada, Spain.

Neuroendocrinology 90, 136-137, 2009 (abstract 95). 98. Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, Seldenrijk

KA, De Krijger RR, Slootweg PJ, Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. Pathology Days, April 23-24, 2009, Zeist, The Netherlands.

99. Bergshoeff VE, Hopman AHN, Bot FJ, Ramaekers FCS, Manni JJ, Kremer B, Speel EJM:

Chromosome instability in tumor resection margins of oral cancers is a predictor of (loco)regional recurrence. Pathology Days, April 23-24, 2009, Zeist, The Netherlands.

100. Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, Seldenrijk KA, De Krijger RR, Slootweg PJ, Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. 100

th Annual Meeting of the AACR, April 18-22, 2009, Denver, USA.

Proceedings AACR 50, 341, 2009 (abstract 1424). 101. Straetmans JMJAA, Olthof NC, Vos I, De Jong J, Kremer B, Speel EJM: Prognostic value

of HPV and cervical metastasis in oropharyngeal squamous cell carcinomas. 100th Annual

Meeting of the AACR, April 18-22, 2009, Denver, USA. Proceedings AACR 50, 390, 2009 (abstract 1629).

102. Klussmann JP, Stenner M, Yosef B, Speel EJM, Huebbers C, Preuss SF, Dienes HP, Odenthal M: Mesenchymal transformation is a crucial step during tumor progression in HPV-related cancer of the oropharynx. 100

th Annual Meeting of the AACR, April 18-22,

2009, Denver, USA. Proceedings AACR 50, 859-860, 2009 (abstract 3564). 103. Theelen W, Reijans M, Simons G, Ramaekers FCS, Meulemans EV, Delvenne P, Speel

EJM, Hopman AHN: Simultaneous MLPA assessment of HPV-type, load, integration and chromosomal aberrations. 25

th International Papillomavirus Conference, May 8-14, 2009,

Malmö, Sweden (abstract P-26.018). 104. Theelen W, Reijans M, Simons G, Ramaekers FCS, Klussmann JP, Von Knebel Doeberitz

M, Speel EJM, Hopman AHN: MLPA and FISH: reliable approaches to identify HPV

84

integration in paraffin tissue. 25th International Papillomavirus Conference, May 8-14, 2009,

Malmö, Sweden (abstract P-26.057). 105. Olthof NC, Straetmans JMJAA, De Jong J, Speel EJM, Kremer B: Prognostic value of HPV

and N-status in tonsillar carcinomas. 25th International Papillomavirus Conference, May 8-

14, 2009, Malmö, Sweden (abstract P-17.10). 106. Straetmans JMJAA, Vos I, Kremer B, Speel EJM: HPV is associated with oropharyngeal

carcinomas and prognosis in non-smokers. 25th International Papillomavirus Conference,

May 8-14, 2009, Malmö, Sweden (P-17.19). 107. Dingemans AM, Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Seldenrijk

KA, De Krijger RR, Slootweg PJ, Smit EF, Thunnissen E, Perren A, Ramaekers FCS, Speel EJM: Comprehensive genetic analysis of typical and atypical lung carcinoids by arrayCGH. 13

th World Conference on Lung Cancer, July 31-August 4, 2009, San Francisco,

USA. J Thoracic Oncol 4, Suppl1, S612, 2009 (abstract P1.023). 108. Speel EJM, Schmidt A, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Offner

F, Sauter G, Cathomas G: Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas. 7

th Annual ENETS Conference, March 11-12, 2010, Berlin,

Germany. Neuroendocrinology 92, 12-13, 2010 (abstract B23). 109. Swarts DRA, Van Suylen RJ, Dingemans AM, De Herder WW, De Krijger RR, Smit EF,

Thunnissen FBJM, Vink A, Perren A, Speel EJM: Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome. 7

th Annual ENETS Conference,

March 11-12, 2010, Berlin, Germany. Neuroendocrinology 92, 13, 2010 (abstract B24). 110. Huysentruyt CJR, Baldewijns MM, Meulemans EV, Ruland AM, Tonk RJW, Vervoort

PSAM, Smits KM, Van de Beek C, Speel EJM: Modified UroVysion scoring criteria increase

the detection rate of urothelial cell carcinoma in patients with equivocal urinary cytology. Pathology Days, April 8-9, 2010, Zeist, The Netherlands (abstract PV33).

111. Speel EJM, Schmidt A, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Willi N, Offner F, Sauter G, Zsikla V, Cathomas G: Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas. Pathology Days, April 8-9, 2010, Zeist, The Netherlands (abstract PV36).

112. Klussmann JP, Stenner M, Weinell A, Ponert T, Hardt A, Hahn M, Preuss S, Speel EJM: Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer. 101

th Annual Meeting of the AACR, April 17-21, 2010,

Washington, USA. Proceedings AACR 51, 417, 2010 (abstract 1729). 113. Speel EJM, Schmidt A, Baumann M, Haesevoets A, Diebold J, Hofman P, Kurrer M, Willi

N, Offner F, Sauter G, Zsikla V, Cathomas G: A high percentage of Merkel cell carcinomas is biologically associated with Merkel cell polyomavirus. 101


April 17-21, 2010, Washington, USA. Proceedings AACR 51, 1297, 2010 (abstract 5352). 114. Speel EJM, Theelen W, Herfs M, Reijans M, Simons G, Meulemans EV, Baldewijns MM,

Ramaekers FCS, Somja J, Delvenne P, Hopman AHN: Increase in viral load, viral integration and gain of telomerase genes during uterine cervical carcinogenesis can be simultaneously assessed by the HPV MLPA-assay. 101


April 17-21, 2010, Washington, USA. Proceedings AACR 51, 1301, 2010 (abstract 5368). 115. Hamers RMPT, Siebers TJH, Haesevoets A, Zwijnenberg IR, Voogd AC, Ramaekers FCS,

Kremer B, Merkx MAW, Slootweg PJ, Speel EJM: Chromosomal instability predicts the progression of premalignant oral lesions. 101

th Annual Meeting of the AACR, April 17-21,

2010, Washington, USA. Proceedings AACR 51, 1388, 2010 (abstract 5720). 116. Hamers RMPT, Siebers TJH, Haesevoets A, Zwijnenberg IR, Voogd AC, Ramaekers FCS,

Kremer B, Merkx MAW, Slootweg PJ, Speel EJM: Aneuploidy detection by DNA image cytometry and fish recognizes progressive premalignant head and neck lesions. 1

st Young

Researchers Day NWHHT, Amsterdam, The Netherlands, September 22, 2010. 117. Mooren JJ, Claessen SMH, Haesevoets A, Hopman AHN, Manni JJ, Kremer B, Ramaekers

FCS, Speel EJM: Chromosome 1 and 7 changes in HPV positive and negative TSCC. 1st

Young Researchers Day NWHHT, Amsterdam, The Netherlands, September 22, 2010. 118. Hamers RMPT, Siebers TJH, Haesevoets A, Zwijnenberg IR, Voogd AC, Ramaekers FCS,

Kremer B, Merkx MAW, Slootweg PJ, Speel EJM: Aneuploidy detection by DNA image cytometry and fish recognizes progressive premalignant head and neck lesions. KWF

85

Symposium on Translational Oncology, Ede, The Netherlands, September 27, 2010 (abstract 18).

119. Swarts DRA, Van Suylen RJ, Dingemans AM, De Herder WW, De Krijger RR, Smit EF, Thunnissen FBJM, Vink A, Perren A, Speel EJM: Deletions of 11q21-q25 are associated with atypical lung carcinoids and a poor clinical outcome. GROW Science Day, Maastricht, The Netherlands, November 17, 2010.

120. Olthof NC, Henfling M, Hopman AHN, Ramaekers FCS, Kremer B, Speel EJM: HPV 16 is integrated in 3 HPV-positive head and neck squamous cell carcinoma cell lines. GROW Science Day, Maastricht, The Netherlands, November 17, 2010.

121. Hamers RMPT, Siebers TJH, Haesevoets A, Zwijnenberg IR, Voogd AC, Ramaekers FCS, Kremer B, Merkx MAW, Slootweg PJ, Speel EJM: Aneuploidy detection by DNA image cytometry and fish recognizes progressive premalignant head and neck lesions. AMP Annual Meeting, November 18-20, 2010, San Jose, USA. JMD 12, 909, 2010 (abstract ST61).

122. Huysentruyt CJR, Baldewijns MM, Meulemans EV, Ruland AM, Tonk RJW, Vervoort PSAM, Smits KM, Van de Beek C, Speel EJM:

Modified UroVysion scoring criteria increase

the detection rate of urothelial cell carcinoma in patients with equivocal urinary cytology. AMP Annual Meeting, November 18-20, 2010, San Jose, USA. JMD 12, 910, 2010 (abstract ST66).

123. Zur Hausen A, Pantulu ND, Pallasch C, Kurz AK, Haugg A, Kassem A, Frenzel L, Sodenkamp S, Kvasnicka HM, Speel EJM, Wendtner CM: Detection of Merkel cell polyomavirus in chronic lymphocytic leukaemia cells by fluorescent in situ hybridization (FISH). Annual USCAP Meeting, February 26-March 4, 2011, San Antonio, USA. Modern Pathol 24, Suppl 2s, 335A (abstract 1421).

124. Creytens D, Schoondermark-Stolk SAH, Speel EJM, Van Gorp J, Pauwels P: Detection of MDM2/CDK4 amplification in lipomatous soft tissue tumours from formalin-fixed, paraffin-embedded tissue: comparison of MLPA and FISH. Annual USCAP Meeting, February 26-March 4, 2011, San Antonio, USA. Modern Pathol 24, Suppl 2s, 11A (abstract 31).

125. Henfling M, Jonkers YMH, Claessen SMH, Ramaekers FCS, Starke A, Schmitt A, Perren A, Sprij D, Hofland LJ, Speel EJM: Expression of EGFR and IGF pathway genes in insulinomas. 8

th Annual ENETS Conference, March 9-11, 2011, Lisbon, Portugal.

Neuroendocrinology 94, Suppl 1, 5, 2011 (abstract B13). 126. Swarts D, Henfling M, Ramaekers FCS, Van Suylen RJ, Dingemans AM, Volante M,

Perren A, Van Velthuysen ML, Van Engeland M, Speel EJM: Reduced MEN1 gene expression in pulmonary carcinoids is associated with metastatic disease. 8

th Annual

ENETS Conference, March 9-11, 2011, Lisbon, Portugal. Neuroendocrinology 94, Suppl 1, 12, 2011 (abstract B37).

127. Speel EJM, Straetmans JMJAA, Vent J, Mujagic Z, Henfling M, Haesevoets A, Haidl B, Huebbers CU, Ramaekers FCS, Kremer B, Klussmann JP: Diagnostic and prognostic value of oncogenic human papillomavirus in patients with carcinoma of unknown primary of the neck. 102

nd Annual Meeting of the AACR, April 2-6, 2011, Orlando, USA. Proceedings

AACR 52, 540, 2011 (abstract 2255). 128. Speel EJM, Haugg A, Pantulu ND, Pallasch C, Kurz AK, Kassem A, Frenzel L, Sodenkamp

S, Kvasnicka HM, Wendtner C, Zur Hausen A: Detection of Merkel cell polyomavirus in chronic lymphocytic leukemia cells by fluorescence in situ hybridization (FISH). 102

nd

Annual Meeting of the AACR, April 2-6, 2011, Orlando, USA. Proceedings AACR 52, 650, 2011 (abstract 2717).

129. Speel EJM, Leusink FKJ, Van Hooff SR, Kummer JA, Van Diest PJ, Koole R, Roepman P, Van den Brekel MWM, Merkx TA, Jansen JC, Schuuring EMD, Brakenhoff RH, Baatenburg de Jong RJ, Slootweg PJ, Holstege FCP, Takes RP: Multi-center validation of a lymph node metastasis gene-expression signature for head and neck squamous cell carcinomas. 102

nd Annual Meeting of the AACR, April 2-6, 2011, Orlando, USA. Proceedings AACR 52,

986, 2011 (abstract 4122). 130. Creytens D, Schoondermark-Stolk SAH, Speel EJM, Van Gorp J, Pauwels P: Detection of

MDM2/CDK4 amplification in lipomatous soft tissue tumours from formalin-fixed, paraffin-

86

embedded tissue: comparison of MLPA and FISH. Pathology Days, April 14-15, 2011, Zeist, The Netherlands (abstract PV40).

131. Swarts DRA, Claessen SMH, Jonkers YMH, Van Suylen RJ, Dingemans AM, De Herder WW, De Krijger RR, Smit EF, Thunnissen FB, Seldenrijk CA, Vink A, Perren A, Ramaekers FCS, Speel EJM: Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome. 14

th World Congress on Lung Cancer, July 3-7, 2011,

Amsterdam, The Netherlands. J Thoracic Oncol 6, Suppl 2, S710-S711, 2011 (abstract P1.021).

132. Swarts DRA, Henfling ME, Haesevoets A, Van Suylen RJ, Dingemans AM, Volante M, Perren A, Van Velthuysen MLF, Burgers JA, Van Criekinge W, Wouters K, Veeck J, Ramaekers FCS, Van Engeland M, Speel EJM: Reduced MEN1 gene expression in pulmonary carcinoids is associated with metastatic disease and poor prognosis. 14

th World

Congress on Lung Cancer, July 3-7, 2011, Amsterdam, The Netherlands. J Thoracic Oncol 6, Suppl 2, S711-S712, 2011 (abstract P1.022).

133. Olthof NC, Huebbers CU, Hopman AHN, Carey T, Hoffmann T, Gollin S, Klussmann JP, Ramaekers FCS, Kremer B, Speel EJM: Identification of HPV-16 integration sites in three HNSCC cell lines. 27

th International Papillomavirus Conference and Clinical Workshop,

September 17-22, 2011, Berlin, Germany (abstract P-24.35). 134. Speel EJM, Huebbers CU, Preuss SF, Kolligs J, Vent J, Stenner M, Drebber U,

Haesevoets A, Klussmann JP: HPV-6 integration marks malignant transformation of a recurrent laryngeal papilloma. 27

th International Papillomavirus Conference and Clinical

Workshop, September 17-22, 2011, Berlin, Germany (abstract P-24.39). 135. Reijans M, Ossel J, Litjens R, Speel EJM, Hopman AHN, Simons G: Multiplex realtime

PCR assay for detecting up to 18 HPV types. 27th International Papillomavirus Conference

and Clinical Workshop, September 17-22, 2011, Berlin, Germany (abstract P-26.21) 136. Kurz AK, Haugg A, Speel EJM, Pantulu ND, Pallasch C, Kvasnicka HM, Cathomas G,

Wendtner CM, zur Hausen A: Fluorescence in situ hybridization identifies integrated Merkel cell polyomavirus DNA in chronic lymphocytic leukemia cells. Jahrestagung der Deutschen, Osterreichischen und Schweizerischen Gesellschaften fur Hamatologie und Onkologie, September 30-October 4, Basel, Switzerland. Onkologie 34, suppl 6, 136, 2011 (abstract P483).

137. Haugg A, Rennspiess D, zur Hausen A, Speel EJM, Cathomas G, Becker J, Schrama D: Detection of Merkel cell polyomavirus in formalin-fixed and paraffin-embedded tissues by fluorescence in situ hybridisation and its correlation with qPCR. 101st Annual Meeting of the USCAP, March 17-23, Vancouver, Canada. Lab Invest 92, suppl 1, 122A (abstract 499). Modern Pathol 25, suppl 2, 122A (abstract 499).

138. Speel EJM, Bergshoeff VE, Siebers TJH, Fleskens AJHM, Haesevoets A, van der Laak JAWM, Merkx MAW, Takes RP, Slootweg PJ, Manni JJ, Kremer B: Chromosomal instability predicts the progression of premalignant head and neck lesions. 101st Annual Meeting of the USCAP, March 17-23, Vancouver, Canada. Lab Invest 92, suppl 1, 316A (abstract 1328). Modern Pathol 25, suppl 2, 316A (abstract 1328).

139. Mooren JJ, Gültekin E, Straetmans JMJAA, Haesevoets A, Huebbers CU, Dienes HP, Wieland U, Kremer B, Speel EJM, Klussmann JP: Strong P16

INK4A-immunostaining predicts

the presence of high-risk human papillomavirus in (pre)malignant lesions of the head and neck mucosa. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1340 (abstract PP5).

140. Straetmans JMJAA, Vente J, Lacko M, Klussmann JP, Speel EJM, Kremer B: Approach and outcome of neck metastasis in unknown primary tumors (UPTs): a comparative study between Maastricht and Cologne. 5th European Congress on Head and Neck Oncology, April 18-21, 2012, Poznan, Poland. Eur Arch Otorhinolaryngol 269, 4, 1373 (abstract PP99).

141. Rios Velazquez E, Hoebers F, F. Miccichè, R. Autorino, I. D'Onofrio, F. Bussu, C. Parrilla,Speel EJM, Straetmans JMJAA, Lambin P: Is a multivariate model more accurate than the traditional TNM staging system in oropharyngeal carcinoma patients to predict outcome? ESTRO 31 Congress, May 9-13, 2012, Barcelona, Spain. Radiotherapy and Oncology 103, suppl 1, S117-S118, 2012 (abstract PD-0298).

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142. Thunnissen E, Kerr K, Bubendorf L, Nonaka D, Blackhall FH, Kammler R, Speel EJM, De Jong J, Martorell M, Stahel RA: Extrnal quality assessment for ALK immunohistochemistry testing in lung adenocarcinoma within the European Thoracic Oncology Platform Lungscape project. ESMO 2012 Congress, September 28-October 2, 2012, Vienna, Austria. Ann Oncol 23, suppl 9, 80, 2012 (abstract 193P).

143. Swarts DRA, Van Neste L, Henfling ME, EijkenboomI, Eijk PP, Van Velthuysen ML, Vink A,

Volante M, Ylstra B, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: Identification of pathways involved in lung carcinoid progression using gene expression profiling. GROW Science Day, November 8, 2012, Maastricht, The Netherlands.

144. Speel EJM, Haugg A, Rennspiess D, zur Hausen A, Cathomas G, Becker J, Schrama D: Comprehensive assessment of Merkel cell polyomavirus in Merkel cell carcinomas: Fluorescence in situ hybridization versus qPCR? AMP 2012 Annual Meeting on Genomic Medicine, October 25-27, Long Beach, CA, USA. J Mol Diagn 14, 677, 2012 (abstract ID40).

145. Speel EJM, Pramana J, Mooren JJ, van den Brekel M, van Velthuysen L, Kremer B, Begg A: HPV status predicts outcome after chemoradiation in head and neck cancer. AMP 2012 Annual Meeting on Genomic Medicine, October 25-27, Long Beach, CA, USA. J Mol Diagn 14, 690, 2012 (abstract ID92).

146. Speel EJM, Bergshoeff VE, Siebers T, Fleskens S, van der Laak J, Merkx T, Takes R, Slootweg PJ, Kremer B: Chromosomal Instability Predicts the Progression of Premalignant Head and Neck Lesions. AMP 2012 Annual Meeting on Genomic Medicine, October 25-27, Long Beach, CA, USA. J Mol Diagn 14, 719, 2012 (abstract ST89).

147. Speel EJM, Olthof NC, Huebbers CU, Kolligs J, Haesevoets A, Henfling ME, Ramaekers FCS, Preuss SF, Drebber U, Lam W, Vucic E, Kremer B, Klussmann JP: Integration of human papillomavirus type 16 in oropharyngeal squamous cell carcinomas does not invariably result in high levels of viral gene transcripts. Joint meeting of the Pathological Society of Great Britain & Ireland and the Dutch Pathological Society, Winter Meeting, January 8-9, Utrecht, The Netherlands. J Pathol 229, suppl 1, S17, 2013.

148. Swarts DRA, Van Neste L, Henfling ME, EijkenboomI, Eijk PP, Van Velthuysen ML, Vink A,

Volante M, Ylstra B, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: Identification of pathways involved in lung carcinoid progression using gene expression profiling. 10th Annual ENETS Conference, March 6-8, 2013, Barcelona, Spain. Neuroendocrinology 97, 2013, in press (abstract P12).

149. Swarts DRA, Van Suylen RJ, Den Bakker M, Van Oosterhout MFM, Thunnissen FBJM, Volante M, Dingemans AM, Scheltinga M, Nap M, Bootsma G, Schapers RFM, Pouwels HMM, Klinkhamer P, Van der Borne B, Ramaekers FCS, Speel EJM: Interobserver variability of pulmonary carcinoids. 10th Annual ENETS Conference, March 6-8, 2013, Barcelona, Spain. Neuroendocrinology 97, 2013, in press (abstract N9).

150. Rudelius M, Swarts DRA, Cleutjens J, Claessen S, Volante M, Ramaekers FCS, Klöppel G, Speel EJM: Impact of KI-67 proliferative index on survival in patients with typical and atypical pulmonary carcinoids. 10th Annual ENETS Conference, March 6-8, 2013, Barcelona, Spain. Neuroendocrinology 97, 2013, in press (abstract O9).

151. Swarts DRA, Henfling ME, Van Neste L, Van Suylen RJ, Dingemans AM, Dinjens WNM, Haesevoets A, Rudelius M, Thunnissen E, Volante M, Van Criekinge W, Van Engeland M, Ramaekers FCS, Speel EJM: Reduced CD44 and OTP gene expression are strong indicators of poor prognosis in pulmonary carcinoids. AACR Annual Meeting, April 6-10, 2013, Washington DC, USA. Proc AACR 2013 (abstract 2380).

152. Klussmann JP, Olthof NC, Huebbers CU, Kolligs J, Haesevoets A, Henfling M, Ramaekers FCS, Preuss SF, Drebber U, Wieland U, Silling S, Kremer B, Speel EJM: HPV16-E2/E4, -E6 and -E7 genes and HPV disrupted human genes show large variation in expression levels in OSCC independent of the viral physical status. AACR Annual Meeting, April 6-10, 2013, Washington DC, USA. Proc AACR 2013 (abstract 4775).

153. Haugg A, Rennspiess D, Speel EJM, Cathomas G, Becker J, Schrama D, zur Hausen A: Comprehensive assessment of Merkel cell polyomavirus in Merkel cell carcinomas: fluorescence in situ hybridization versus qPCR? Dutch Pathology Days, April 17-19, 2013, Zeist, The Netherlands.

88

154. Hillen LM, Kamsteeg EJ, Schoots J, Tiebosch A, Speel EJM, Roemen GM, Peutz-Koostra CJ, Stumpel CTRM:

Refining the diagnosis of congenital nephrotic syndrome on long-term

stored tissue: uncommon 1097G-A (Arg366His) mutation of the WT1 gene causing Denys-Drash syndrome. Dutch Pathology Days, April 09-11, 2014, Zeist, The Netherlands.

155. Derks JL, Speel EJM, Bendek M, Dingemans AMC: Classification of pulmonary neuro-endocrine tumors. Too diverse for the clinician. Dutch Lung Days, April 23-24, 2014, Utrecht, The Netherlands.

156. Straetmans JMJAA, Stuut M, Hoebers F, Lacko M, Speel EJM, Kremer B: Human papillomavirus confuses the prognostic value of UICC TNM-classification in tonsillar squamous cell carcinomas. 5th World congres of the IFHNOS, Annual meeting of the AHNS, July 26-30, 2014, New York, USA (abstract P0649) JAMA Otolaryngology-Head and Neck Surgery 2014 (ahns.jnabstracts.com).

157. Derks JL, Dingemans AMC, Van Suylen RJ, Thunnissen E, Den Bakker MA, PALGA: Dutch Pathology Registry, Speel EJM: A national pathology registration analysis of applied terminology in pulmonary neuroendocrine tumors/carcinomas, is the WHO 2004 classification in line with clinical practice? 12th Annual ENETS Meeting, March 11-13, 2015, Barcelona, SP. Neuroendocrinology 102, 145, 2015 (abstract P1).

158. Derks JL, Hendriks LE, Damhuis RA, Speel EJM, Dingemans AMC: Clinical characteristics and overall survival of large cell neuroendocrine carcinoma (LCNEC) compared to other subtypes of lung cancer: Results of a population-based registry. 12th Annual ENETS Meeting, March 11-13, 2015, Barcelona, SP. Neuroendocrinology 102, 146, 2015 (abstract P2).

159. Speel EJM, Reuschenbach M, Huebbers CU, Prigge ES, Bermejo JL, Kalteis S, Preuss S, Kolligs J, Olthof NC, Kremer B, Wagner S, Klussmann JP, Vinokurova S, von Knebel Doeberitz M: Methylation status of HPV16 E2-binding sites identifies subtypes of HPV-associated oropharyngeal squamous cell carcinomas. Annula Meeting of the AACR, April 18-22, 2015, Philadelphia, USA. Cancer Res 75, Suppl 15, 2015 (abstract 828).

160. Derks JL, Dingemans AMC, Van Suylen RJ, Thunnissen E, Den Bakker MA, PALGA: Dutch Pathology Registry, Speel EJM: Aberrant pulmonary neuroendocrine tumour nomenclature in daily pathology practice: Limited tissue is an issue. 27th European Congress of Pathology, September 5-9, 2015, Belgrade, SRB. Virchows Arch 467, Suppl 1, S256, 2015 (abstract PS-22-037).

161. Derks JL, Speel EJM, van Suylen RJ, Dingemans AMC: Large cell neuro-endocrine carcinoma: how accurate are the WHO 2004 criteria applied? 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA. J Thorac Oncol 10, Suppl 2, S508. (abstract P1.08-024).

162. Derks JL, Speel EJM, van Suylen RJ, Thunnissen E, den Bakker MA, Dingemans AMC: Population based nomenclature of pulmonary neuroendocrine tumors in daily practice: how common is it? 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA. J Thorac Oncol 10, Suppl 2, S634 (abstract P2.08-023).

163. Thunnissen E, Skov BG, Sørensen JB, Mellemgaard A, Groen HJ, Schuuring E, Timens W, van den Heuvel M, de Jong J, Monkhorst K, de Langen AJ, van der Drift MA, Looijen-Salamon MG, Dingemans AM, Speel EJM, Samii S, Duplaquet F, Weynand B, Durando X, Penault-Llorca F, Pauwels P, Kerr K, Nicolson M, Finn S, Schildgen O, Bubendorf L, Rothschild S, Hiemstra AC, Witte B, Smit EF: A prospective multicenter study for ALK IHC+ metastasized NSCLC. 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA. J Thorac Oncol 10, Suppl 2, S649 (abstract P3.01-022).

164. Hendriks L, Smit E, Vosse BAH, Mellema WW, Heideman DAM, Bootsma GP, Westenend M, Pitz C, De Vries MJ, Houben R, Thunnissen E, Bendek M, Speel EJM, Dingemans AMC: EGFR mutated patients: different pattern and outcome of metastatic bone disease and brain metastases? 16th World Conference on Lung Cancer, September 6-9, 2015, Denver, USA (abstract P1.06-015).

165. Mellema WW, Burgers S, Groen HJM, Dingemans A, Thunnissen E, Heideman DAM, De Jong J, Timens W, Speel EJM, Smit EF: A phase II study of sorafenib and metformin in patients with stage IV non-small cell lung cancer (NSCLC) with a KRAS mutation. 16th























89

World Conference on Lung Cancer, September 6-9, 2015, Denver, USA (abstract P3.11-037).

166. Speel EJM, Verhees F, Jacobs R, Cornet I, Kremer B: Efficacy of the antiviral agent Cidofovir to inhibit the growth of HPV-positive and -negative head and neck squamous cell carcinomas in vitro. AHNS 9th International Conferemce on head and neck cancer, July 16-20, 2016, Seattle, USA (abstract P505) JAMA Otolaryngology-Head and Neck Surgery 2016 (ahns.jnabstracts.com).

167. Rennspiess D, Hillen L, Speel EJM, Haugg A, Winnepenninckx V, zur Hausen A: p16 expression in seborrheic keratosis in relation to the presence of Merkel cell polyomavirus. 16th World Congress of cancers of the skin, August 31-September 3, 2016, Vienna, Austria (abstract P205). Melanoma Res 26, E114-E114, Suppl 1, 2016.

168. Soltermann A, Rulle U, Dafni O, Verbeken E, Thunnissen E, Warth A, Cheney R, Sejda A, Speel EJM, Madsen LB, Nonaka D, Navarro A, Sansano I, Marchetti A, Finn S, Kammler R, Schulze K, Bubendorf L, Stahel RA, Lungscape, OBO: Prevalence and clinical associations of PTEN loss in non-small cell lung carcinoma (NSCLC) patients (pts) of the European Thoracic Oncology Platform (ETOP) Lungscape cohort. ESMO 2016 Congress, October 7-11, 2016, Copenhagen, Denmark (abstract 1525P). Ann Oncol 27, Suppl 6, 2016.

169. Derks J, Suylen RJ, Thunnissen E, Den Bakker M, Groen H, Smit E, Damhuis R, Van den Broek E, Dingemans AM, Speel EJM: Chemotherapy for Pulmonary Large Cell Neuroendocrine Carcinomas: Does the Regimen Matter? 14th Annual ENETS Conference, March 8-10, 2017, Barcelona, Spain.(abstract J5). Neuroendocrinology 105, 184, Suppl 1, 2017.

170. Speel EJM, Pelgrim R, 't Hart N, Werner N, Mastik M, Hendriks L, van der Heijden E, Looijen-Salamon M, de Langen A, Staal-van den Brekel J, Riemersma S, van den Borne B, Thunnissen E, Dingemans A, Hiltermann T, van den Berg A, Timens W, Schuuring E, Groen H: ALK-IHC is a Better Predictor for Outcome After ALK Inhibition with Crizotinib than ALK-FISH in Stage IV Non-small Cell Lung Cancer. 1st Global Congress on Molecular Pathology, April 3-5, 2017, Berlin, Germany (abstract ST45LB). J Mol Diagn 19, Suppl, 543, 2017

171. Speel EJM, Dafni U, Schöbel M, Finn SP, Tischler V, Sejda A, Marchetti A, Thunnissen E, Verbeken EK, Warth A, Sansano J, Cheney R, Nonaka D, Monkhorst K, Hager H, Martorell M, Savic S, Kerr KM, Tsourti Z, Geiger T, Kammler R, Schulze K, Das-Gupta A, Shames D, Peters S, Stahel RA, Consortium L: MET Overexpression, Amplification and Exon-14 Skipping in Patients with Resected NSCLC: Prevalence and Clinical Association Results from the European Thoracic Oncology Platform Lungscape Project. 1st Global Congress on Molecular Pathology, April 3-5, 2017, Berlin, Germany (abstract ST46LB). J Mol Diagn 19, Suppl, 543-544, 2017

172. Chteinberg E, Rennspiess D, Tauchmann S, Winnepenninckx V, Speel EJM, Kurz AK, Zenke M, Hausen AZ: PI3K p110 delta expression in Merkel cell carcinoma cell lines. 13th Congress of the EADO, May 3-6, 2017, Athens, Greece (abstract P155). J Eur Acad Dermatol Venerol 31, 96-97, Suppl 3, 2017.

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Documents

Curriculum Vitae Name: Ernst-Jan M. Speel date: 27-02-2018 ......6. Teaching experience Regular courses per faculty, University of Maastricht and MUMC Faculty of Health, Medicine and