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CURRICULUM VITAE NAME: David E. Hinton Division of Environmental Science and Policy Nicholas School of the Environment A-333 LSRC, Science Drive Box 90328 Duke University Durham, North Carolina USA 27708-0328 Telephone: (919) 613-8038 Fax: (919) 684-8741 Email: dhinton@duke.edu TITLE: Nicholas Professor of Environmental Quality DATE OF BIRTH: 01/04/1942 PLACE OF BIRTH: Hattiesburg, Mississippi EDUCATION Mississippi College, B.S. 1965 Zoology Clinton, Mississippi Univ. of Mississippi, Med. Ctr. M.S. 1967 Anatomy Jackson, Mississippi Univ. of Mississippi, Med. Ctr. Ph.D. 1969 Anatomy Jackson, Mississippi Vanderbilt University National Science Foundation. Short Course In Histochemistry and Cytochemistry 1971 University of Maryland, School of Medicine Baltimore, MD, National Institutes of Health, Post Doctoral Trainee in Electron Microscopy and Pathology, under Direction of Benjamin F. Trump, M.D. 1973 – 1975 Armed Forces Institute of Pathology, Wash. D.C. Short Course in Comparative Pathology 1975

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Karolinska Institute, Department of Pathology (II), Stockholm, Sweden, Post Doctoral Trainee in Biochemical Techniques Applied to the Study of Microsomal Enzymes; under Direction of Hans Glaumann, M.D., Ph.D. 1976 MEMBERSHIP IN PROFESSIONAL SOCIETIES Society of Toxicologic Pathologists Society of Toxicology International Academy of Pathology Society of Environmental Toxicology and Chemistry PROFESSIONAL EXPERIENCE Chair, Environmental Health and Ecotoxicology, 2003 - Present Master of Environmental Management Program Nicholas School of the Environment And Earth Sciences Duke University Durham, North Carolina

Nicholas Professor of Environmental Quality 2000 – Present

Nicholas School of the Environment And Earth Sciences Duke University Durham, North Carolina Director, Ecotoxicology Lead Campus Graduate 1996-2000 Program. UC System-wide Toxic Substances Research & Teaching Program University of California, Davis Davis, California Professor of Aquatic Toxicology 1994-2000 Department of Anatomy, Physiology & Cell Biology University of California, Davis Davis, California Professor of Veterinary Medicine and Aquatic 1986-1994 Toxicologist in the Experiment Station, Department of Medicine and Epimediology School of Veterinary Medicine University of California, Davis, Davis, California

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Chair, Graduate Group in Pharmacology and 1990-1995 Toxicology, University of California, Davis Davis, California 95616 Professor, Departments of Anatomy and 1980-1986 Pathology West Virginia University Medical Center, Morgantown, West Virginia Adjunct Associate Professor of Pathology, 1979-1989 Department of Pathology, Medical College of Ohio, Toledo, Ohio Associate Professor, Department of Anatomy, 1977-1980 West Virginia University Medical Center, Morgantown, West Virginia Part-time Assistant Professor for Research, 1977-1981 Department of Pathology, University of Maryland, School of Medicine Baltimore, Maryland Assistant Professor and Coordinator of 1975-1976 Pathology Teaching Program, Department of Pathology, University of Maryland, School of Medicine, Baltimore, Maryland Instructor, Department of Pathology, 1974-1975 University of Maryland, School of Medicine, Baltimore, Maryland Research Associate, Department of Pathology, 1973-1974 University of Maryland, School of Medicine, Baltimore, Maryland Assistant Professor, Department of Anatomy, 1970-1973 University of Louisville, School of Medicine Health Sciences Center Louisville, Kentucky Research Associate, Water Resources Laboratory, 1970-1973 University of Louisville Louisville, Kentucky Instructor, Department of Anatomy, 1969-1970

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University of Louisville, School of Medicine, Health Sciences Center, Louisville, Kentucky Graduate Instructor, University of Mississippi, 1966-1969 School of Medicine, Jackson, Mississippi N.I.H. Pre-doctoral Trainee in Anatomy, 1965-1969 University of Mississippi, School of Medicine, Jackson, Mississippi PUBLICATIONS (Refereed Journals) 1. 1968 Hinton, D.E. and Williams, W.L. Hepatic fibrosis associated with aging in

four stocks of mice. J. Gerontol. 23:203-211. 2. 1971 Hinton, D.E. Know about water pollution by heavy metals. Bassmaster

6:46-47. 3. 1972 Hinton, D.E., Snipes, R.L. and Kendall, M.W. Morphology and enzyme

histochemistry in liver of largemouth bass (Micropterus salmoides). J. Fish. Res. Board Can. 29:531-534.

4. 1973 Hinton, D.E., Kendall, M.W. and Koenig, J.C. Enzyme and tissue alteration in

fishes: A measure of water quality. Research Report Number 68. University of Kentucky, Water Resources Institute, University of Kentucky Press, Lexington, 88 pages.

5. 1973 Hinton, D.E., Kendall, M.W. and Silver, B.B. Use of histological and

histochemical assessments in the prognosis of the effects of aquatic pollutants. Biological Methods for the Assessment of Water Quality, ASTM STP 528, American Society for Testing and Materials. p. 194-208.

6. 1974 Kendall, M.W. and Hinton, D.E. Renal tubular morphology in the channel

catfish (Ictalurus punctatus) kidney. J. Fish. Res. Board Can. 31:346-347. 7. 1975 Hinton, D.E. and Koenig, J.C., Jr. Acid phosphatase activity in subcellular

fractions of fish liver exposed to methyl mercuric chloride. Comp. Biochem. Physiol. 50B:621-625.

8. 1975 Hinton, D.E. Perfusion fixation of whole fish for electron microscopy. J.

Fish. Res. Board Can. 32:416-422. 9. 1976 Hinton, D.E. and Pool, C.R. Ultrastructure of the liver in channel catfish

Ictalurus punctatus (Rafinesque). J. Fish Biol. 8:209-220.

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10. 1976 Hinton, D.E., Jones, R.T. and Herman, R.L. Glomerular mesangial fibrosis in hatchery reared rainbow trout Salmo gairdneri (Richardson). J. Fish. Res. Board Can. 33:2551-2559. 11. 1976 Heatfield, B.M., Hinton, D.E. and Trump, B.F. Adenocarcinoma of the kidney. II. Enzyme histochemistry of renal adenocarcinoma induced in rats by N-(4'-fluro-4-biphenyl) acetamide. J. Natl. Cancer Inst. 57:795-808. 12. 1976 Kasza, L., Hinton, D.E., Weinberger, M.A., Trump, B.F., Brouwer, E.A. and

Carter, C. J. Acute, subacute, and residual effects of polychlorinated biphenyl (PCB) in rats. II. Pathology and electron microscopy of liver and serum enzyme study. J. Toxicol. Environ. Hlth. 1:689-703.

13. 1976 Kolaja, G.J. and Hinton, D.E. Histopathologic alterations in shell gland

accompanying DDT-induced thinning of egg shells. Environ. Pollut. l0:225-23l.

14. 1977 Kolaja, G.J. and Hinton, D.E. In vitro inhibition of microsomal calcium

Atpase from eggshell gland of mallard duck. Bull. Environ. Contam. Toxicol. 17:591-594.

15. 1978 Kolaja, G.J. and Hinton, D.E. Effects of DDT on eggshell quality and calcium

adenosine triphosphatase. J. Toxicol. Environ. Hlth. 3:699-704. 16. 1978 Kasza, L., Weinberger, M.A., Hinton, D.E., Trump, B.F., Patel, C., Friedman,

L. and Garthoff, L.H. Comparative toxicity of polychlorinated biphenyl and polybrominated biphenyl in rat liver. Light and electron microscopic alterations after subacute dietary exposure. J. Environ. Path. Toxicol. 1:241-257.

17. 1978 Lipsky, M.M., Klaunig, J.E. and Hinton, D.E. Comparison of acute response

to PCB in liver of rat and channel catfish: A biochemical and morphological study. J. Toxicol. Environ. Hlth. 4:107-121.

18. 1978 Hinton, D.E., Glaumann, J. and Trump, B.F. Studies on the cellular toxicity of

polychlorinated biphenyls (PCBs). I. Effect of PCBs on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of rat liver: A morphological and biochemical study. Virchows Archiv. B. Cell Pathology 27:279-306.

19. 1978 Kolaja, G.J. and Hinton, D.E. Ultrastructural alterations in the eggshell gland

epithelium of the mallard duck after chronic exposure to DDT. U.S. Army Tech. Rept. ARSCL-TR-77034, 16 pages.

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20. 1978 Kolaja, G.J. and Hinton, D.E. Ultrastructural alterations in the eggshell gland epithelium of the mallard duck after chronic exposure to DDT. Environ. Pollut. 17:237-244.

21. 1978 Hinton, D.E., Klaunig, J.E. and Lipsky, M.M. PCB-induced alterations in

teleost liver: A model for environmental disease in fish. Mar. Fish. Rev. 40:47-50.

22. 1979 Klaunig, J.E., Lipsky, M.M., Trump, B.F. and Hinton, D.E. Biochemical and

ultrastructural changes in teleost liver following subacute exposure to PCB. J. Environ. Path. Toxicol. 2:953-963.

23. 1979 Kolaja, G.J. and Hinton, D.E. DDT-induced reduction in eggshell thickness,

weight and calcium is accompanied by inhibition of calcium ATPase. In

: Animals as monitors of environmental pollutants. Scarpelli, D., Nielsen, S. and Migaki, G. (eds). National Academy of Science, Washington, D.C., pp. 309-318.

24. 1979 Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J. and Trump, B.F. Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection. Path. Res. Pract. 164:178-185.

25. 1979 Hinton, D.E., Lipsky, M.M., Heatfield, B.M. and Trump, B.F. Opposite

effects of lead on chemical carcinogenesis in kidney and liver of rats. Bull. Environ. Contam. and Toxicol. 23:464-469.

26. 1980 Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J. and Trump, B.F. Gamma glutamyl transpeptidase in safrole-induced, presumptive premalignant mouse hepatocytes. Carcinogenesis 1:151-156. 27. 1980 Hinton, D.E., Heatfield, B.M., Lipsky, M.M. and Trump, B.F. Animal Model:

Chemically induced renal tubular carcinoma in rats. Amer. J. Path. 100-317-320.

28. 1981 Walker, E.R., Fidler, S.F. and Hinton, D.E. Morphology of the

buccopharyngeal portion of the gill in the fathead minnow Pimephales promelas (Rafinesque). Anat. Rec. 200:67-81.

29. 1981 Jones, G.S., Miles, P.R., Lantz, R.C., Hinton, D.E., Shreve, J. and Castranova,

V. Effects of metallic ions on oxygen consumption of isolated type II pneumocytes. In: Coal Conversion and the Environment. Mahlum, D.D., Gray, R.H., and Felix, W.D. (eds.). Technical Information Center, U.S. D.O.E. 54:352-365.

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30. 1981 Hinton, D.E., Heatfield, B.M., Lipsky, M.M. and Trump, B.F. Renal tubular carcinoma, Model No. 211. In: Handbook- Animal Models of Human Disease. Fasc. 10. Capen, C.C., Hackel, D.B., Jones, T.C. and Migaki, G. (eds.). Washington, D.C., Registry of Comparative Pathology, Armed Forces Institute of Pathology, 4 pp. 31. 1981 Zuchelkowski, E.M., Lantz, R.C. and Hinton, D.E. Effects of acid-stress on epidermal mucous cells of the brown bullhead Ictalurus nebulosus (LeSueur): A morphometric study. Anat. Rec. 200:33-39. 32. 1981 Lipsky, M.M., Hinton, D.E., Klaunig, J.E. and Trump, B.F. Studies on the

biology of hepatocellular neoplasia in the mouse. I. Sequential histological study of the pathogenesis of safrole-induced hepatocellular carcinoma and transplantation of hepatic tumors. J. Natl. Cancer Inst. 67:365-376.

33. 1981 Lipsky, M.M., Hinton, D.E., Klaunig, J.E., Goldblatt, P.J.and Trump, B.F.

Studies on the biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis and reaction to rapid iron loading in BALB/c mouse liver during safrole-induced carcinogenesis. J. Natl. Cancer Inst. 67:377-392.

34. 1981 Lipsky, M.M., Hinton, D.E., Klaunig, J.E. and Trump, B.F. Studies on the biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas in BALB/c mice. J. Natl. Cancer Inst. 69:393-404. 35. 1981 Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Chacko, J. and

Trump, B.F. Mouse liver cell culture. I. Hepatocyte isolation. In Vitro 17:913-925.

36. 1981 Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M. and Trump, B.F.

Mouse liver cell culture. II. Primary culture. In Vitro l7:926-934. 37. 1981 Hinton, D.E., Klaunig, J.E., Jack, R.M., Lipsky, M.M., and Trump, B.F. In

vitro evaluation of the channel catfish (Ictalurus punctatus) as a test species in chemical carcinogenesis studies. Aquatic Toxicology and Hazard Assessment. Fourth Conference ASTM STP 737. Branson, D.R. and Dickson, K. L. (eds.). American Society for Testing and Materials, pp. 226-238.

38. 1982 Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M., Knipe, S.M. and

Trump, B.F. Morphologic and functional studies of mouse hepatocytes in primary culture. Anat. Rec. 204:231-243.

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39. 1982 Jones, G.S., Miles, P.R., Lantz, R.C., Hinton, D.E. and Castranova, V. Ionic contents and regulation of cellular volume in rat alveolar type II cells. J. Appl. Physiol. 53:258-266.

40. 1982 Hinton, D.E., Klaunig, J.E., Lipsky, M.M., Jack, R., Kahng, M.A., Sanefugi,

H., Jones, R.T. and Trump, B.F. Chemical carcinogenesis in fish: Induction of hepatic drug metabolizing enzymes and bacterial mutogenesis with polycyclic aromatic hydrocarbons (PAH). In: Symposium - Carcinogenic Polynuclear Aromatic Hydrocarbons in the Marine Environment. Richards, N.L., and Jackson, B.L. (eds.). EPA-600/9-82-013. Environmental Laboratory, Office of Research and Development, Gulf Breeze, Florida, pp. 110-123.

41. 1982 Hinton, D.E., Stoner, L.C., Burg, M. and Trump, B.F. Structural heterogeneity

in the distal nephron of the salamander (Ambystoma tigrinum). An electron microscopic study of isolated tubule segments. Anat. Rec. 204:21-32.

42. 1982 Hinton, D.E., Lipsky, M.M., Klaunig, J.E. and Kolaja, G.J.Hepatic morphology of the lesser bushbaby (Galago). A light and electron microscopic study. In: The Lesser Bushbaby (Galago) as an Animal model selected topics. Haines, D.E. (ed.). CRC Press Inc., Boca Raton, Florida, pp. 231-236. 43. 1982 Jones, R.R., Klaunig, J.E., Sanefuji, H. and Hinton, D.E. A method for the

organ explant culture of fish kidney tubules. J. Tiss. Cult. Meth. 7(4):151-154.

44. 1983 Hinton, D.E., Lantz, R.C., Birch, K. and Burrell, R. Quantitative morphologic

studies of the lung following inhalation of bacterial endotoxin. In: Proceedings of 7th Cotton Dust Research Conference, January 3-4, pp. 39-44.

45. 1983 Hinton, D.E., Klaunig, J.E., Lipsky, M.M., Jack, R.M. and Trump, B.F. EPA

Project Summary, EPA-600/53-83-076. Detection of Mutagenic/carcinogenic Alteration in Fish, pp. 1-8. U.S. E.P.A., Environmental Research Laboratory, Duluth, MN.

46. 1984 Hinton, D.E., Walker, E.R., Pinkstaff, C.A. and Zuchelkowski, E.M. A

morphological survey of teleost organs important in carcinogenesis with attention to fixation. Natl. Cancer Inst. Monogr. 65:291-320.

47. 1984 Hinton, D.E., Lantz, R.C. and Hampton, J.A. Effect of age and exposure to a

carcinogen on the structure of the medaka liver: A morphometric study. Natl. Cancer Inst. Monogr. 65:239-249.

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48. 1984 Lantz, R.C., Hinton, D.E. and Burrell, R. The effect of inhaled bacterial lipopolysaccharide (LPS) on pulmonary endothelium. Proceedings of the 8th Cotton Dust Research Conference. Atlanta, Georgia. pp. 109-111.

49. 1984 Lantz, R.C. and Hinton, D.E. Pulmonary toxicity associated with fly ash from fluidized bed coal combustion. II. Cellular morphometry of distal lung following a single intratracheal instillation. Toxicol. Appl. Pharmacol. 75:44-51. 50. 1984 Brogan, W.C., Eacho, P.I., Hinton, D.E. and Colby, H.D. Effects of carbon

tetrachloride on adrenocortical structure and function in Guinea Pigs. Toxicol. Appl. Pharmacol. 75:118-127.

51. 1984 Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M. and Trump. B.F.

Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. Toxicol. Path. 12:119-125.

52. 1984 Hinton, D.E. and Couch, J.A. Pathobiological measures of marine pollution

effects. In: Concepts in Marine Pollution Measurements. White, H. (ed.). Maryland Sea Grant College, University of Maryland, College Park. pp. 5-32.

53. 1985 Zuchelkowski, E.M., Pinkstaff, C.A. and Hinton, D.E. Mucosubstance

histochemistry in control and acid-stressed epidermis of brown bullhead catfish, Ictalurus nebulosus (Le Sueur). Anat. Rec. 212:327-335 and 396-398.

54. 1985 Hinton, D.E., Hampton, J.A. and McCuskey,P.A. The Japanese medaka (Oryzias latipes) liver tumor model: Review of literature and new findings. In Environmental Impact and Health Effects. Volume 5. Jolley,

: Water Chlorination: Chemistry,

R.L. et all (eds.). Lewis Publishing Inc., Chelsea, Michigan, 1985. pp. 439-450. 55. 1985 Hampton, J.A., McCuskey, P.A., McCuskey, R.S. and Hinton, D.E.

Functional units in rainbow trout (Salmo gairdneri) liver. I. Arrangement and histochemical properties of hepatocytes. Anat. Rec. 213:166-175.

56. 1985 Lantz, R.C, Burrell, R.R., and Hinton, D.E. Morphometric alterations in the

lung induced by inhaled bacterial endotoxin. Acta Stereol. 4:207-210. 57. 1985 Lantz, R.C., Hinton, D.E. and Burrell, R. The effect of repeated

lipopolysaccharide (LPS) aerosol exposure on distal lung structure. Proceedings of the 9th Cotton Dust Research Conference. pp. 148-150.

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58. 1985 Burrell, R., Lantz, R.C. and Hinton, D.E. The effect of complement on the LPS aerosol generated response of the lung. Proceedings of the 9th Cotton Dust Research Conference. pp. 154-156. 59. 1986 Lantz, R.C. and Hinton, D.E. Development of alterations in hamster distal lung following exposure to fly ash from fluidized bed coal combustion: A morphometric study. Toxicol. Appl. Pharmacol.

82:132-139. 60. 1986 Hinton, D.E., Hampton, J.A. and Lantz, R.C. Morphometric analysis of liver

in rainbow trout: quantitatively defining an organ important in xenobiotic metabolism. Mar. Environ. Res. 17:238-239.

61. 1986 Lantz, R.C., Burrell, R. and Hinton, D.E. Morphometric alterations in the lung

induced by inhaled bacterial endotoxin. Acta. Stereol. 4:207-210. 62. 1986 Lipsky, M.M., Hinton, D.E., Tanner, D.T. and Trump, B.F. Reversibility,

persistence and progression of safrole-induced mouse liver lesions following cessation of exposure. In: Mouse Liver Neoplasia, Current Perspectives. Popp, J.A. (ed.). Hemisphere Publishing Corporation, Washington, pp. 161-177.

63. 1986 Zuchelkowski, E.M., Lantz, R.C. and Hinton, D.E. Skin mucous cell response

to acid-stress in male and female brown bullhead catfish, Ictalurus nebulosus (LESUEUR). Aquat. Toxicol. 8:139-148.

64. 1986 McCuskey, P.A., McCuskey, R.S. and Hinton, D.E. Electron microscopy of

cells of the hepatic sinusoids in rainbow trout (Salmo gairdneri). In: Cells of the Hepatic Sinusoid, Volume 1, Kirn, A., Knook, D.L. and Wisse, E. (eds.). Kupffer Cell Foundation, Leiden, Netherlands, pp. 489-494.

65. 1986 Lantz, R.C., Burrell, R.R. and Hinton, D.E. Morphometric alterations in the

lung induced by inhaled bacterial endotoxin. Microbeam Analysis, pp. 597-598.

66. 1987 Banks, M.A., Martin, W.G. and Hinton, D.E. Vitamin E deficiency in the

adult Syrian golden hamster. J. Nutr. Growth Cancer 4:91-108. 67. 1987 Banks, M.A., Martin, W.G. and Hinton, D.E. Long-term histological

observations in the liver and pancreas of vitamin E and selenium deficient Syrian golden hamster. J. Nutr. Growth Cancer 4:109-128.

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68. 1987 Banks, M.A., Martin, W.G., Shinozuka, H. and Hinton, D.E. Effect of vitamin deficiency on pancreatic, hepatic and biliary tumors induced by N-nitrosobis (2-oxopropyl)-amine in the Syrian golden hamster. J. Nutr. Growth Cancer 4:221-237.

69. 1987 Hinton, D.E., Lantz, R.C., Hampton, J.A., McCuskey, P.R. and McCuskey,

R.S. Normal versus abnormal structure: Considerations in morphologic responses of teleosts to pollutants. Environ. Health Perspec. 71:139-146.

70. 1988 Burrell, R.R., Lantz, R.C. and Hinton, D.E. Mediators of pulmonary injury

induced by inhalation of bacterial endotoxin. Amer. Rev. Resp. Dis. 137:100-105.

71. 1988 Hinton, D.E., Couch, J.A., Teh, S.J., and Courtney, L.A. Cytological changes

during progression of neoplasia in selected fish species. Aquat. Toxicol. 11:77-112.

72. 1988 Hinton, D.E., Laurén, D.J., Teh, S.J. and Giam, C.S. Cellular composition and

ultrastructure of hepatic neoplasms induced by diethylnitrosamine in Oryzias latipes. Mar. Environ. Res. 24:307-310.

73. 1988 Miller, M.R., Hinton, D.E., Blair, J.B. and Stegeman, J.J.

Immunohistochemical localization of cytochrome P45OE in liver, gill and heart of scup (Stenotomus chrysops) and rainbow trout (Salmo gairdneri). Mar. Environ. Res. 24:37-39.

74. 1988 Lantz, R.C., Stanley, C. and Hinton, D.E. Development of alterations in the

lung induced by inhaled silica: A morphometric study. Proceedings International Symposium on Respirable Dust in the Mineral Industries. Frantz, R.L. and Ramoni, R.B. (eds.). The Pennsylvania State University, University Park, Pennsylvania ISBN:0-93671-76-7. pp. 177-180.

75. 1988 Kent, M.L., Myers, M.S., Hinton, D.E., Eaton, W.D. and Elston, R.A.

Suspected toxicopathic hepatic necrosis and megalocytosis in pen-reared Atlantic salmon Salmo Salar in Puget Sound, Washington, USA. Dis. Aquat. Org. 4:91-100.

76. 1988 Hampton, J.A., Lantz, R.C. and Hinton, D.E. Functional units in rainbow trout (Salmo gairdneri; Richardson) liver. II. The biliary system. Anat. Rec. 221:619-634. 77. 1988 Droy, B.F. and Hinton, D.E. Allylformate-induced hepatotoxicity in rainbow trout Mar. Environ. Res. 24:259-264. 78. 1988 Droy, B.F., Miller, M.R., Freeland, T.M. and Hinton, D.E. Immuno-histochemical detection of CCl4-induced, mitosis-related DNA synthesis in livers of trout and rat. Aquat. Toxicol. 13:155 -166.

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79. 1989 Hampton, J.A., Lantz, R.C. and Hinton, D.E. Functional units in rainbow trout (Salmo gairdneri, Richardson) liver: III. Morphometric analysis of parenchyma, stroma, and component cell types. Amer. J. Anat. 185:58-73.

80. 1989 Lipsky, M.M., Trump, B.F. and Hinton, D.E. Histogenesis of dieldrin and

DDT-induced hepatocellular carcinoma in BALB/c mice. J. Environ. Pathol. Toxicol. Oncol. 9(1):79-93.

81. 1989 Laurén, D.J., Halarnkar, P.P., Hammock, B.D. and Hinton, D.E. Microsomal and cytosolic epoxide hydrolase, and glutathione S- transferase activities in the gill, liver, and kidney of the rainbow trout, Salmo gairdneri: Baseline levels and optimization of assay conditions. Biochem. Pharmacol. 38:881-887. 82. 1989 Miller, M.R., Blair, J.B. and Hinton, D.E. DNA repair synthesis in isolated

rainbow trout liver cells. Carcinogenesis 10(6):995-1001. 83. 1989 Droy, B.F., Davis, M.E. and Hinton, D.E. Mechanism of allyl formate-

induced hepatotoxicity in rainbow trout. Toxicol. Appl. Pharmacol. 98:313-324.

84. 1989 Laurén, D.J., Wishkovsky, A., Groff, J.M., Hedrick, R.P., and Hinton, D.E.

Toxicity and pharmacokinetics of the antibiotic, Fumagillin, in yearling rainbow trout (Salmo gairdneri). Toxicol. Appl. Pharmacol. 98:444-453.

85. 1989 Miller, M.R., Hinton, D.E. and Stegeman, J.J. Cytochrome P-450E induction

and localization in gill pillar (endothelial) cells of scup and rainbow trout. Aquat. Toxicol. 14:307-322.

86. 1989 Stegeman, J.J., Miller, M.R. and Hinton, D.E. Cytochrome P-450 IA1

induction and localization in endothelium of vertebrate (teleost) heart. Molec. Pharmacol. 36:723-729.

87. 1989 Blair, J.B., Hinton, D.E., and Miller, M.R. Morphological changes in trout

hepatocytes exposed to acetaminophen. Mar. Environ. Res. 28:357-361. 88. 1989 Miller, M.R., Hinton, D.E., and Blair, J.B. Characterization of cytochrome P-

450IA1 in isolated trout liver cells. Mar. Environ. Res. 28:105-108. 89. 1989 Hinton, D.E. Environmental contamination and cancer in fishes. Mar.

Environ. Res. 28:411-416. 90. 1989 Hinton, D.E., Laurén, D.J., McCuskey, R.S., McCuskey, P.A., and Lantz, R.C.

In vivo microscopy of liver microvasculature in rainbow trout (Oncorhynchus mykiss). Mar. Environ. Res. 28:407-410.

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91. 1989 Giam, C.S., Holliday, T.L., Williams, J.L., Weller, R.R., Mayernik, J.A., and Hinton, D.E. Laser desorption-ionization FT-ICR Mass spectrometry: DNA-adduct bases, nucleosides, and nucleotides. Mar. Environ. Res. 28:309-312.

92. 1989 Okihiro, M.S. and Hinton, D.E. Lymphoma in the Japanese medaka Oryzias

latipes. Dis. Aquat. Org. 7:79-87. 93. 1989 Adams, S.M., Shepard, K.L., Greeley, M.S., Jimenez, B.D., Ryon, M.G.,

Shugart, L.R., McCarthy, J.F., and Hinton, D.E. The use of bioindicators for assessing the effects of pollutant stress on fish. Mar. Environ. Res. 28:459-464.

94. 1989 Hinton, D.E. Production of tumors in fish following laboratory exposures to carcinogens. In Proceedings of the Workshop on in vitro assessment of contaminated sediments for potential carcinogenicity. Mac, M.J. and Johnson, R.D. (eds.). Great Lakes Water Quality Board of the International Joint Commission and U.S. Environmental Protection Agency. Duluth, Minnesota, pp. 19-23. 95. 1990 Blair, J.B., Miller, M.R., Pack, D., Barnes, R., Teh, S.J., and Hinton, D.E.

Isolated trout liver cells: Establishing short-term primary cultures exhibiting cell-cell interactions. In Vitro Cell. Develop. Biol. 26:237-249.

96. 1990 Hinton, D.E., and Laurén, D.J. Liver structural alterations accompanying chronic toxicity in fishes: Potential biomarkers of exposure. In: Biological Markers of Environmental Contamination. McCarthy, J. and Shugart, L.R. (eds.), Lewis Publishing Inc., Chelsea, Michigan, pp. 17-57. 97. 1990 Hinton, D.E. and Laurén, D.J. 1990. Integrative histopathological approaches for detecting effects of environmental stressors on fishes. In: Biological Indicators of Stress in Fish. Adams, S.M. (ed.), Amer. Fish. Soc. Symp. 8:51-66. 98. 1990 Marty, G.D., Nunez, J., Laurén, D.J. and Hinton, D.E. Age -dependent changes in toxicity of N-nitroso compounds to Japanese medaka (Oryzias latipes) embryos. Aquat. Toxicol. 17:45-62. 99. 1990 Laurén, D.J., Teh, S.J., and Hinton, D.E. The cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka. Cancer Res. 50:5504-5514.

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100. 1990 Jimenez, B.D., Oikari, A., Adams, S.M., Hinton, D.E., and McCarthy, J.F. Hepatic enzymes as biomarkers: Interpreting the effects of environmental and toxicological variables. In: Biological Markers of Environmental Contamination. McCarthy, J. and Shugart, L.R. (eds.), Lewis Publishing Inc., Chelsea, Michigan, pp. 123-142. 101. 1990 Marty, G.D., Cech, J.J., Hinton, D.E. Effect of incubation temperature on oxygen consumption and ammonia production by Japanese medaka (Oryzias latipes) eggs and newly hatched larvae. Environ. Toxicol. Chem. 9:1399-1405. 102. 1990 Bordner, C.E., Doroshov, S.I., Hinton, D.E., Pipkin, R.E., Fridley, R.B., and

Haw, F. Evaluation of marking techniques for juvenile and adult white sturgeons reared in captivity. Amer. Fish. Soc. Symp. 7:293-303.

103. 1990 Hinton, D.E. Histological Techniques. In: Biological Methods In Fisheries,

Schreck, C.B. and Moyle, P.B. (eds.). Amer. Fish. Soc. Spec. Publ. Series 191-211.

104. 1990 Parker, L.M., Laurén, D.J., Cooke, J.B., and Hinton, D.E. Metabolism of

endogenous and xenobiotic aldehydes by rainbow trout (Oncorhynchus mykiss) liver fractions. Aquat. Toxicol. 18:1-12.

105. 1991 Chuang, L.F., Hinton, D.E., Cheung, A.T.W., and Chuang, R.Y. Induction of

Differentiation in human myeloblastic leukemia ML-1 cells by heptachlor, a chlorinated hydrocarbon insecticide. Toxicol. Appl. Pharmacol. 109:98-107.

106. 1991 Marty, G.D., Wetzlich, S., Nunez, J.M., Craigmill, A. and D. E. Hinton. Fish-based biomonitoring to determine toxic characteristics of complex chemical mixtures: documentation of bioremediation at a pesticide disposal site. Aquat Toxicol. 19:329-340. 107. 1992 DeKoven, D.L., Nunez, J.M., Lester, S.M., Conklin, D.E., Marty, G.D.,

Parker, L.M. and Hinton, D.E.: A purified diet for medaka (Oryzias latipes): Refining a fish model for toxicological research. Lab. Anim. Sci. 42:185-194.

108. 1992 Hinton, D.E., Baumann, P.C., Gardner, G.R., Hawkins, W.E., Hendricks, J.D., Murchelano, R.A. and Okihiro, M.S. 1992. Histopathological biomarkers. In: Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. Huggett, R.J. Kimerle, R.A., Mehrle, Jr., P.M., Bergman, H.L. (eds.) Lewis Publishers, Inc., Boca Raton, FL. pp. 155-209.

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109. 1992 Groff, J.M., Hinton, D.E., McDowell, T.S., and Hedrick, R.P. Progression and resolution of megalocytic hepatopathy with exocrine pancreatic metaplasia in a population of cultured juvenile striped bass (Morone saxatilis). Dis. Aquat. Org. 13:189-202. 110. 1992 Braunbeck, T., Teh, S.J., Lester, S.M. and Hinton, D.E. Ultrastructural

alterations in hepatocytes of medaka (Oryzias latipes) exposed to diethylnitrosamine. Toxicol. Pathol. 20:179-196.

111. 1992 Hinton, D.E., Teh, S.J., Okihiro, M.S., Cooke, J.B., Parker, L.M.

Phenotypically altered hepatocyte populations in diethylnitrosamine-induced medaka liver carcinogenesis: resistance, growth, and fate. Mar. Environ. Res. 34:1-5.

112. 1992 Lester, S.M., Braunbeck, T.A., Teh, S.J., Stegeman, J.J., Miller, M.R. and

Hinton, D.E. Immunocytochemical localization of cytochrome P450IA1 in liver of rainbow trout (Oncorhynchus mykiss). Mar. Environ. Res. 34:117-122.

113. 1992 Okihiro, M.S., Whipple, J., Groff, J.M. and Hinton, D.E. Chromatophoromas and related hyperplastic lesions in pacific rockfish (Sebastes). Mar. Environ. Res. 34:53-57.

114. 1993 Hinton, D.E. Toxicologic histopathology of fishes: a systemic approach and

overview. In: Pathobiology of Marine and Estuarine Organisms. Couch, J.A. and Fournie, J.W. (eds). New York: CRC Press, Boca Raton, FL. pp. 177-215.

115. 1993 Parker, L.M., Laurén, D.J., Hammock, B.D., Winder, B. and Hinton, D.E.

Biochemical and histochemical properties of hepatic tumors of rainbow trout Oncorhynchus mykiss. Carcinogenesis 14:211-217.

116. 1993 Teh, S.J. and Hinton, D.E. Detection of enzyme histochemical markers of hepatic preneoplasia and neoplasia in medaka (Oryzias latipes). Aquat. Toxicol. 24:163-182. 117. 1993. Okihiro, M.S., Whipple, J.A., Groff, J.M. and Hinton, D.E.

Chromatophoromas and chromatophore hyperplasia in Pacific Rockfish (Sebastes spp.). Cancer Res. 53:1761-1769.

118. 1993 Miller, M.R., Wentz, E., Blair, J.B., Pack, D., and Hinton, D.E. (1993).

Acetaminophen toxicity in cultured trout liver cells. I. Morphological alterations and effects on cytochrome P450 1A1. Exper. Molec. Pathol. 58: 114-126.

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119. 1993 Miller, M.R., Saito, N., Blair, J.B., and Hinton, D.E. (1993). Acetaminophen toxicity in cultured trout liver cells. II. Maintenance of cytochrome P450 1A1. Exper. Molec. Pathol. 58:127-138.

120. 1993 Lester, S.M., Braunbeck, T.A., Teh, S.J., Stegeman, J.J., Miller, M.R. and

Hinton, D.E. Hepatic cellular distribution of cytochrome P-450 IA1 in rainbow trout (Oncorhynchus mykiss): an immunohisto- and cytochemical study. Cancer Res. 53:3701-3706.

121. 1993 Hinton, D.E. Cells, cellular responses, and their markers in chronic toxicity of

fishes. In: Aquatic Toxicology: Molecular, Biochemical and Cellular Perspectives. G.K. Ostrander and D.M. Malins, eds. Lewis Publishers/CRC Press, pp. 207-239.

122. 1994 Bailey, H.C., Alexander, C., DiGiorgio, C., Miller, M., Doroshov, S.I. and

Hinton, D.E. The effect of agricultural discharge on striped bass (Morone saxatilis) in California's Sacramento-San Joaquin drainage. Ecotoxic. 3:123-142.

123. 1995 Ostrander, G.K. Blair, J.B., Stark, B.A., Marley, G.M. Bales, W.D., Veltri, R.W., Hinton, D.E., Okihiro, M., Ortego, L.S. and Hawkins, W.E. Long-term primary culture of epithelial cells from rainbow trout (Oncorhynchus mykiss) liver. In Vitro Cellular Developmental Biology 31:367-378 124. 1995 Marty, G.D., Cech Jr., J.J., and Hinton, D.E. Oxygen consumption by larval

Japanese medaka with inflated or noninflated swimbladders. Transactions of the American Fisheries Society 124:623-627.

125. 1995 Bennett, W.A., Ostrach, D.J. and Hinton, D.E. Larval striped bass condition in

a drought-stricken estuary: evaluating pelagic food-web limitation. Ecological Applications 5:680-692.

126. 1995 Wolfe, M.F., Seiber, J.N., and Hinton, D.E. Aqueous sample preparation for

bioassay using supercritical fluid extraction. Environmental Toxicology and Chemistry 14:1001-1009, 1995.

127. 1995 Blair, J.B., Ostrander, G.K., Miller, M.R. and Hinton, D.E. Isolation and characterization of biliary epithelial cells from rainbow trout liver. In Vitro Cellular Developmental Biology- Animal 31:778-787. 128 1995. Marty, G.D., Hinton, D.E. and Summerfelt, R.C. Histopathology of

swimbladder noninflation in walleye (Stizostedion vitreum) larvae: role of development and inflammation. Aquaculture 138:35-48.

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129. 1995. Gawlicka, A., Teh, S.J., Hung, S.S.O., Hinton, D.E. and de la Noüe, J. Histological and histochemical changes in the digestive tract of white sturgeon larvae during ontogeny. Fish Physiol. Biochem. 14:357-371.

130. 1996 Singh, Y., Cooke, J.B., Hinton, D.E. and Miller, M.G. Trout liver slices for

metabolism and toxicity studies. Drug Metabolism and Disposition 24:7-14. 131. 1996 Anderson, M.J., Olsen, H., Matsumura, F. and Hinton, D.E. In Vivo

modulation of 17 -estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by -naphthoflavone. Toxicol. Appl. Pharmacol. 137:210-218.

132. 1996 Anderson, M.J., Miller, M.R., and Hinton, D.E. In Vitro modulation of 17 -

estradiol-induced vitellogenin synthesis: effects of cytochrome P4501A1 inducing compounds on rainbow trout (Oncorhynchus mykiss) liver cells. Aquat.Toxicol. 34:1-24.

133 1996 Spies, R.B., Stegeman, J.J., Hinton, D.E., Woodin, B., Smolowitz, R.,

Okihiro, M. and Shea, D. Biomarkers of hydrocarbon exposure and sublethal effects in embiotocid fishes from a natural petroleum seep in the Santa Barbara Channel. Aquat. Toxicol. 34:195-219

134. 1996 Bailey, H.C., DiGiorgio, C., Kroll, K., Miller, J.L., Hinton, D.E. and Starrett,

G. Development of procedures for identifying pesticide toxicity in ambient waters: carbofuran, diazinon, chlorpyrifos. Env. Tox. Chem. 15(6): 837-845.

135. 1996 Torten, M., Liu, Z., Okihiro, M.S., Teh, S.J. and Hinton, D.E. Induction of ras

oncogene mutations and hepatocarcinogenesis in medaka (Oryzias latipes) exposed to diethylnitrosamine. Marine Environ. Res. 42, Vol. 1-4:93-98.

136. 1996 Villalobos, S.A., Anderson, M.J., Denison, M.S., Hinton, D.E., Tullis, K.,

Kennedy, I.M., Jones, A.D., Chang, D.P.Y., Yang, G.S, and Kelly, P. Toxicity of a trichloroethylene combustion generated aerosol with three vertebrate bioassays. Environ. Health Perspect. 104:734-743

137. 1996 Hinton, D.E., Guest Editor, Pollutant Responses in Marine Organisms

(PRIMO 8). Special Issue of Marine Environmental Research, Vol. 42, Nos. 1-4, June-October, 1996, 405 pp.

138. 1996. Wiedmer, M., Fink, M.J., Stegeman, J.J., Smolowitz, R., Marty, G.D. and Hinton D.E. Cytochrome P450 induction and histopathology in preemergent pink salmon from oiled spawning sites in Prince William Sound. Am. Fish. Soc. Symp. 18:509 -517.

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139. 1996 Washburn, B.S., Vines, C.X., Baden, D.H., Hinton, D.E. and Walsh, P.J. Differential effects of brevetoxin and β-naphthoflavone on xenobiotic metabolizing enzymes in striped bass (Morone saxatilis). Aquat. Toxicol. 35:1-10.

140. 1996 Ruebner, B.H., Bannasch, P., Hinton, D.E., Cullen, J.M. and Ward, J.M. Foci of altered hepatocytes, mouse. In: Jones, T.C., Popp, J.A. and Mohr, U. (Eds). Monographs of Pathology of Laboratory Animals, Digestive System, Second Edition. Springer, Berlin, Heidelberg, New York, pp 38-49. 141. 1996 Hose, J.E., McGurk, M.D., Marty, G.D., Hinton, D.E., Biggs, E.D. and Baker T.T. 1996. Sublethal effects of the Exxon Valdez oil spill on herring embryos and larvae: morphological, cytogenetic, and histopathological assessments, 1989-1991. Can. J. Fish.Aquat. Sci. 53:2355-2365. 142. 1996 Adams, S.M., Ham, K.D., Greeley, M.S., LeHew, R.F., Hinton, D.E. and Saylor, C.F. Downstream gradients in bioindicator responses: point source contaminant effects on fish health. Can. J. Fish. Aquat. Sci. 53:2177-2187. 143. 1997 Teh, S.J., Adams, S.M. and Hinton, D.E. Histopathologic biomarkers in feral freshwater fish populations exposed to different types of contaminant stress. Aquat. Toxicol. 37:51-70. 144. 1997 Hinton, D.E. Histologic responses signifying exposure or effect and their application to aquatic ecotoxicology. In: Ecotoxicology: Responses, Biomarkers, & Risk Assessment, an OECD

Workshop, J.T. Zelikoff, ED. SOS Publications, FairHaven, NJ, USA 145. 1997 Boorman, G.A., Botts, S., Bunton, T.E., Fournie, J.W., Harshbarger, J.C., Hawkins, W.E., Hinton, D.E., Joikinen, M.P., Okihiro, M.S. and Wolfe, M.J. Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): Consensus of a National Toxicology Program pathology working group. Toxicol. Pathol. 25:202-210. 146. 1997 Marty, G.D., Heintz, R.A. and Hinton, D.E. Histology and teratology of pink salmon larvae near the time of emergence from gravel substrate in the laboratory. Can. J. Zool. 75:978-988.

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147. 1997 Marty, G.D., Short, J.W., Dambach, D.M., Willits, N.H., Heintz, R.A., Rice, S.D., Stegeman, J.J., and Hinton, D.E. Ascites, premature emergence, increased gonadal cell apoptosis, and cytochrome P4501A induction in pink salmon larvae continuously exposed to oil-contaminated gravel during development. Can. J. Zool. 75:989-1007. 148. 1997 Washburn, B.S., Rein, K.S., Baden, D.G., Walsh, P.J., Hinton, D.E., Tullis, K. and Denison, M.S. 1997. Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin is a ligand of the aryl hydrocarbon receptor. Arch. Biochem. Biophys. 343:149-156. 149. 1997 Marty, G.D., Hose, J.E., McGurk, M.D., Brown, E.D. and Hinton, D.E. Histopathology and cytogenetic evaluation of Pacific herring larvae exposed to petroleum hydrocarbons in the laboratory or in Prince William Sound, Alaska, after the Exxon Valdez oil spill. Can. J. Fish. Aquat. Sci 54:1846-1857. 150. 1998 Marty, G.D., Freiberg, E.F., Meyers, T.R., Wilcock, J., Farver, T.B., and Hinton, D.E. Viral hemorrhagic septicemia virus,

Ichthyophonus hoferi, and other causes of morbidity in Pacific herring Clupea pallasi spawning in Prince William Sound, Alaska, USA. Dis. Aquat. Org. 32 (1):15-40.

151. 1998 Teh, S.J. and Hinton, D.E. Gender-specific growth and hepatic neoplasia in medaka (Oryzias latipes). Aquat. Toxicol. 41:141-159. 152. 1998 Hamm, J.T., Wilson, B.W. and Hinton, D.E. Organophosphate- induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). NeuroToxicol. 19(6):853-870. 153. 1998 Hinton, D.E. and J.A. Couch. Architectural pattern, tissue and cellular morphology in livers of fishes: Relationship to experimentally-induced neoplastic processes. In: Fish Ecotoxicology. Braunbeck, Hinton, D.E. and Streit, B. (eds.) Birkhäuser Verlag, Basel, Switzerland. pp. 141-164. 154. 1998 Hinton, D.E., Multiple Stressors in the Sacramento River. In: Fish Ecotoxicology. Braunbeck, Hinton, D.E. and Streit, B. (eds.) Birkhäuser Verlag, Basel, Switzerland. pp. 303-317. 155. 1998 Braunbeck, T., Hinton, D.E. and Streit. B. eds. 1998. Fish Ecotoxicology. Birkhäuser Verlag, Basel, pp. 396.

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156. 1999 Olsson, P-E., Westerlund, L., Teh, S.J., Billsson, K., Berg, A.H., Tysklind, M., Nilsson, J., Eriksson, L-O. and Hinton, D.E. Effects of maternal exposure to estrogen and PCB on different life stages of zebrafish (Danio rerio). Ambio 28:100-106. 157. 1999 Cooke, J.B. and Hinton, D.E. 1999. Promotion by 17 –estradiol and 17 β-hexachlorocyclohexane of hepatocellular tumors in medaka, Oryzias latipes.Aquatic Toxicology 45:127-145. 158. 1999 Marty, G.D., M.S. Okihiro, E.D. Brown, D. Hanes, and D.E. Hinton. Histopathology of adult Pacific herring in Prince William Sound, Alaska, after the Exxon Valdez oil spill. Can. J. Fish. Aquat. Sci. 56:419-426. 159. 1999 Okihiro, M.S. and Hinton, D.E. Progression of hepatic neoplasia in medaka (Oryzias latipes) exposed to diethylnitrosamine. Carcinogenesis 20:933-940. 160. 1999 Koger, C.S., Teh, S.J. and Hinton, D.E.Variations of light and temperature regimes and resulting effects on reproductive parameters in medaka (Oryzias latipes). Biology of Reproduction 61:1287-1293. 161. 1999 Werner, I., Deanovic, L.A., Connor, V., de Vlaming, V., Bailey, H.C. and Hinton, D.E. Insecticide-caused toxicity to Ceriodaphnia dubia (Cladocera) in the Sacramento/San Joaquin River Delta, California, USA. Environmental Toxicology & Chemistry 19:215-227. 162. 1999 Werner, I. and D.E. Hinton. 1999. Field validation of hsp70 stress proteins as biomarkers in Asian clam (Potamocorbula amurensis): is downregulation an indicator of stress? Biomarkers 4:473-484. 163. 1999 Teh, S.J., S.L. Clark, C.L. Brown, S. N. Luoma, and D. E. Hinton. Enzymatic and histopathologic biomarkers as Indicators of contaminant exposure and effect in Asian Clam (Potamocorbula amurensis). Biomarkers 4:497-509. 164. 1999 Fairbrother, A., Ankley, G. T., Birnbaum, L. T., Bradbury, S. P.,

Francis, B., Gray, L. E., Hinton, D., Johnson, L. L., Peterson, R. E., and G. Van Der Kraak. Chapter 5. Reproductive and Developmental Toxicology of Contaminants in Oviparous Animals. In and Developmental Effects of Contaminants in Oviparous Vertebrates.

Reproductive

R. T. Di Giulio and D. E. Tillitt (eds.). SETAC PRESS, Pensacola. Pp. 283-361.

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165. 2000 Okihiro, M.S. and Hinton, D.E. Partial hepatectomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): Histologic, immuno- and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasia. Toxicol. Pathol., 28(2):342-356. 166. 2000 Kullman, S.W., Hamm, J.T., and Hinton, D.E. Identification and

characterization of a cDNA encoding cytochrome P450 3A from the freshwater teleost medaka (Oyzias latipes). Arch. Biochem. Biophys. 380(1): 29-38.

167. 2000 Villalobos, S.A., Hamm, J.T., Teh, S.J., and D.E. Hinton. Thiobencarb-induced embryotoxicity in medaka (Oryzias latipes): stage-specific toxicity and the protective role of the chorion. Aquatic Toxicology 48: 309-326. 168. 2000 Hamm, J.T. and D. E. Hinton. The role of development and duration of exposure to the embryotoxicity of diazinon. Aquatic Toxicology 48:403-418. 169. 2000 Koger, C.S., Teh, S.J. and Hinton, D. E. Determining the sensitive developmental stages of intersex induction in medaka (Oryzias latipes) exposed to 17 beta-estradiol or testosterone. Mar. Environ. Res. 50(1-5): 201-6. 170. 2000 Teh, S.J., Werner, I. and Hinton, D.E. Sublethal effects of chromium-VI in the Asian clam (Potamocorbula amurensis). Mar Environ Res. 50(1-5):295-300. 171. 2000 De Vlaming, V., V. Connor, C. DiGiorgio, H.C. Bailey, L. A. Deanovic and D. E. Hinton. Application of whole effluent toxicity test procedures to ambient water quality assessment. Env. Tox. and Chem., 19: 42-62. 172. 2000 Villalobos, S. A., Papoulias, D. M., Meadows, J., Blankenship, A. L., Pastva, S. D., Kannan, K., Hinton, D. E., Tillitt, D. E., and Giesy, J. P. Toxic responses of medaka, d-rR strain, to polychlorinated naphthalene mixtures after embryonic exposure by in ovo nanoinjection: a partial life-cycle assessment. Environ. Tox. Chem., 19: 432-440. 173. 2001 Hamm, J.T., Wilson, B.W. and D. E. Hinton. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol. Sci. 62(2): 304-313.

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174. 2001 Hinton, D. E., Segner, H. and Braunbeck, T. Chapter 4. Toxic responses of the liver. In: Target Organ Toxicity in Marine and Freshwater Teleosts. Volume 1 Organs. D. Schlenk and W.H. Benson (eds.) Taylor and Francis, London. pp. 224-268. 175. 2001 Arukwe, A., Kullman, S.W. and Hinton, D.E. Differential biomarker gene and protein expressions in nonylphenol and estradiol-17beta treated juvenile rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 129(1): 1-10. 176. 2001 Kullman, S. W. and Hinton, D.E. Identification, characterization, and ontogeny of a second cytochrome P450 3A gene from the

fresh water teleost medaka (Oryzias latipes). Mol Reprod Dev. 58(2): 149-58. 177. 2001 Newman, J.W. Denton, D. L., Morisseau, C., Koger, C.S., Wheelock, C.E., Hinton, D. E., and Hammock, B.D. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ. Health. Perspect. 109(1) Environ. Health Perspect. 109(1): 61-6. 178. 2001 Werner, I., C.S. Koger, L. A. Deanovic, and D.E. Hinton. Toxicity of methyl-tert-butyl ether to freshwater organisms. Environmental Pollution 111:83-88. 179. 2001. Werner, I., C. S. Koger, J.T. Hamm and D. E. Hinton. Ontogeny of the Heat Shock Protein, hsp 70 and hsp 60, Response and Developmental Effects of Heat-Shock in the Teleost, Medaka (Oryzias latipes). Environmental Sciences 8:013-029. 180. 2001. Arukwe, A., S. W. Kullman and D. E. Hinton. Molecular cloning,

characterization and expression of the Eggshell Zona Radiata Gene in Nonylphenol and Estrogen-Treated Rainbow Trout

(Oncorhynchus mykiss). Comparative Biochem. Physiol., 132(C): 315-326. 181. 2001. Soimasuo, M.R., Werner, I., Villalobos, A. and Hinton, D.E. (2001).

Cytochrome P450 1A1 and stress protein induction in early life stages of medaka (Oryzias latipes) exposed to trichloroethylene (TCE) soot

and different fractions. Biomarkers 6(2):133-145. 182. 2002. Fan, T., Higashi, R., and D. E. Hinton (Guest Editors) 2002. Special

Issue: Selenium Aquatic Criteria. Aquatic Toxicology 57(1-2):1-113.

183. 2002. Fan, T.W.-M., S.J. Teh, D. E. Hinton, and R.M. Higashi 2002 Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California. Aquatic Toxicology 57:

65-84.

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184. 2002. Werner, I., L. A. Deanovic, D. E. Hinton, J. D. Henderson, G.H. de G. H. de Oliveria, B. W. Wilson, W. Krueger, W.W. Wallender,

M. N. Oliver, and F. G. Zalom. Toxicity of Stormwater Runoff After Dormant Spray Application of Diazinon and Esfenvalerate (AsanaR) in a French Prune Orchard, Glenn County, California, USA. Bulletin Environmental Contamination and Toxicology 68:

29-36. 185. 2002 Washburn, B. S., J. J. Moreland, A. M. Slaughter, I. Werner, D. E. Hinton, and B. M. Sanders. Effects of handling on heat shock

protein expression in rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry 21(3):557-560.

186. 2002. Werner, I., Geist, J., Okihiro, M., Rosenkranz, P., and D.E. Hinton. Effects of dietary exposure to the pyrethroid pesticide

esfenvalerate on medaka (Oryzias latipes). Marine Env. Res. 54(3-5):609-614.

187. 2002. Davis, C.R., Okihiro, M., and D. E. Hinton. Effects of husbandry practices, gender, and normal physiological variation on growth and reproduction of Japanese medaka, Oryzias latipes. Aquatic Toxicology 60: 185-201. 188. 2002 Viant, M. R., Pincetich, C.A., Walton, J.H., Tjeerdema, R.S., and

D. E. Hinton. Utilizing in vivo nuclear magnetic resonance spectroscopy to study sublethal stress in aquatic organisms. Marine Environmental Res. 54(3-5):553-7.

189. 2002. Angermann T., Wallender W.W., Henderson J. D., Oliveira G. H.,

Wilson B.W., Werner I., Deanovic L.A., Hinton D. E., Osterli P., Krueger W., Oliver M. N. and Zalom F. G. (2002). Runoff from orchard floors. Journal of Hydrology 265:178-194.

190. 2002. Arukwe, A., S. W. Kullman, and D. E. Hinton. Molecular cloning,

characterization and expression of the eggshell zona radiata gene in nonylphenol and estrogen-treated rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. 132:315-326.

191. 2003. Denton, D.L., Wheelock, C.E., Murray, S.A., Deanovic, L.A., Hammock, B.A., and D.E. Hinton. Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Env. Tox. and Chem. 22:336-341. 192. 2003. Liu, Z., S. W. Kullman, D. E. Hinton, and M. Torten. ras Oncogene Mutations in Diethylnitrosamine-induced Hepatic Tumors in Medaka.

Mut. Res.539 (1-2):43-53

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193. 2003. Gonzalez-Doncel, M., Larrea, M., Sanchez-Fortun, S., and Hinton, D.E. Influence of water hardening of the chorion on cadmium accumulation in Medaka (Oryzias latipes) eggs. Chemosphere 52:75-83 194. 2003. Gonzalez-Doncel, M., de la Pena, E., Barrueco, C., and Hinton, D.E. Stage sensitivity of medaka (Oryzias latipes) eggs and embryos to Permethrin. Aquatic Toxicology 62:255-268 195. 2003. Kullman, S.W., Matsumura, F., and Hinton, D.E. Estrogen signaling in trout liver: Estrogen receptor and mitogenic mediated cellular responses. Environmental Sciences 10(4): 223-237 196. 2003. Werner, I., Clark, S.L., and Hinton, D.E. Biomarkers aid understanding of aquatic organism responses to environmental stress. California Agriculture 57(4): 110-115 197. 2003. Kullman, S. W., F. Matsumura, and D. E. Hinton. 2003. Estrogen

signaling in trout liver: Activation of the rasp21/MAP-Kinase Pathway. Environ. Sci. 10:223-227

198. 2003. Anderson, M.J., Cacela, D., Beltman, D., Teh, S.J., Okihiro, M.S., Hinton, D.E., Denslow, N., Zelikoff, J.T. Biochemical and toxicopathic Biomarkers assessed in smallmouth bass recovered from a polychlorinated biphenyl-contaminated river. Biomarkers 8(5):371- 393. 199. 2004. Rocha, E., Hinton, D.E., and Wisse, E. Comparative Hepatology: A journal for all hepatologists with immediate Open Access to quality peer-reviewed research. Editorial. Comp Hepatol. 3(1):1. 200. 2004. Hinton DE, Wakamatsu Y, Ozato K, and Kashiwada S. Imaging Liver Development/Remodeling in the See-Through Medaka Fish. Comp Hepatol. 3 Suppl 1:S30 201. 2004 Kullman, S.W., S. Kashiwada and D.E. Hinton. 2004. Analysis of medaka Cytochrome P4503A homotropic and heterotropic cooperativity. Mar. Environ. Res. 58: 469-473. 202. 2004. Gonzalez-Doncel, M., S. A. Villalobos, M. S. Okihiro and D. E. Hinton

"Does shaking alter the time of hatching in incubated medaka (Oryzias latipes) embryos?" Bull Environ Contam Toxicol

73(2): 364-70.

203. 2005. Hinton, D. E., S. W. Kullman, D. C. Bencic, R. C. Hardman, P. J. Chen, M. Carney and D.C. Volz. Resolving mechanisms of toxicity while pursuing ecotoxicological relevance? Marine Pollution Bull. 51:635- 648.

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204. 2005. Gonzalez-Doncel, M., C. Fernandez-Torija, D. E. Hinton and J. V. Tarazona (2005). "Stage-specific toxicity of cypermethrin to medaka (Oryzias latipes) eggs and embryos using a refined methodology for an in vitro fertilization bioassay." Arch Environ Contam Toxicol 48(1): 87-98.

205. 2005. Gonzalez-Doncel, M., M. S. Okihiro, S. A. Villalobos, D. E. Hinton and J.V. Tarazona (2005). "A quick reference guide to the normal

development of Oryzias latipes (Teleostei, Adrianichthyidae)." Journal of Applied Ichthyology 21(1): 39-52.

206. 2005. Volz, D.C., D. C. Bencic, J. M. Law, D. E. Hinton, and S. W. Kullman. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces organ-specific differential gene expression in Japanese medaka (Oryzias latipes). Toxicol. Sci. 85:572–584. 207. 2005. Pincetich, C. A., M. R. Viant, D. E. Hinton and R. S. Tjeerdema. "Metabolic changes in Japanese medaka (Oryzias latipes) during embryogenesis and hypoxia as determined by in vivo P-31 NMR." Comparative Biochemistry and Physiology C-Toxicology & Pharmacology 140(1): 103-113. 208. 2005. Kashiwada, S., D.E. Hinton and S.W. Kullman. Functional characterization of medaka CYP3A38 and CYP3A40 by expression in a recombinant Baculovirus system. Comp. Biochem. Physiol. 141:338- 348. 209. 2006. Volz, D.C., Hinton, D.E., Law, J.M. and S.W. Kullman. Dynamic gene expression changes precede dioxin-induced liver pathogenesis. TOXICOLOGICAL SCIENCES 89 (2):524-534. 210. 2006. Viant MR, Pincetich CA, Hinton DE and R. Tjeerdema. Toxic Actions of dinoseb in medaka (Oryzias latipes) embryos as deter- mined by in vivo P-31 NMR, HPLC-UV and H-1 NMR metabolomics. AQUATIC TOXICOLOGY 76 (3-4): 329-342. 211. 2006. Chen, P.J., K.G. Linden, E.J. Rosenfeldt, and S. W. Kullman. Removal and bio-analytical analysis of Endocrine Disrupting Compounds in water following direct photolysis and UV advanced Oxidation. CHEMOSPHERE 65 (7): 1094-1102. 212. 2006. Kashiwada, S., N. Tatarazako, K. Arizono, Y. Wakamatsu, K. Ozato, and

D.E. Hinton. Development of in vivo and in vitro measurement for EROD activity with teleost medaka (Oryzias latipes). Marine Environmental Research 62: S389-S389.

213. 2006. Oxendine, S. L., J. Cowden, D.E. Hinton, and S. Padilla. Adapting the

medaka embryo assay to a high-throughput approach for developmental toxicity testing." NeuroToxicology

27(5): 840-845.

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214. 2006. Oxendine, S. L., J. Cowden, D.E. Hinton, and S. Padilla. Vulnerable windows for developmental ethanol toxicity in the Japanese medaka fish (Oryzias latipes)." Aquatic Toxicology

80(4): 396-404.

215. 2007. Chen, P.J., S.W. Kullman, K.G. Linden, and D.E. Hinton. Comparisons of polychromatic and monochromatic UV-based treatments of bisphenol-A in water via toxicity assessments. CHEMOSPHERE 68(6): 1041-1049. 216. 2007. Kashiwada, S., K. Goka, H. Shiraishi, K. Arizono, Y. Wakamatsu, K. Ozato,

and D.E. Hinton. Age-dependent in situ hepatic and gill CYP1A activity in the see-through medaka (Oryzias latipes). Comparative Biochemistry and Physiology C-Toxicology & Pharmacology 145(1): 96-102.

217. 2007. Kashiwada, S., M. Kameshiro, H. Tatsuta, Y. Sugaya, S.W. Kullman, D.E.

Hinton, and K. Goka. Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes). Comparative Biochemistry and Physiology C-Toxicology & Pharmacology 145(3): 370-378.

218. 2007. Hardman R.C., Kullman, S.W., Volz, D.C., Hinton, D.E. A new look at

vertebrate liver architecture: 3 dimensional reconstructions from medaka (Oryzias latipes). Anatomical Record 290(7):770-782.

219. 2007. Chen, P. C., E. Rosenfeldt, S. W. Kullman, D. E. Hinton and K. G. Linden.

Biological Assessments of a Mixture of Endocrine Disruptors at Environmentally Relevant Concentrations in Natural River Water following UV/H2O2 Oxidation. Sci. Total Environ. 376:18-26.

220. 2007. Hardman, R.C., Kullman, S.W. and D.E. Hinton. Application of in vivo methodologies to investigation of biological structure, function and xenobiotic response in see-through medaka (Oryzias latipes). The Fish Biology Journal, MEDAKA 11:43-65. 221. 2008. Deng, X., Carney, M., Hinton, D.E., Lyon, S., Woodside, G., Duong, C.N., Kim, S-D., and D. Schlenk. 2008. Biomonitoring recycled water in the Santa Ana River Basin in Southern California. Journal of Toxicology and Environmental Health, Part A. 71(2):109-118. 222. 2008. Di Giulio, R.T. and D.E. Hinton, eds. The Toxicology of Fishes. CRC Press. Taylor and Francis Group. Boca Raton. 1071 pages. ISBN 0-4152-4868-X. 223. 2008. Di Giulio, R.T. and D.E. Hinton. Introduction. The Toxicology of Fishes. Di

Giulio, R.T. and D.E. Hinton, eds. CRC Press. Taylor and Francis Group. Boca Raton. Pages 3-7. 224. 2008. Hinton, D.E., Segner, H., Au, D.W.T., Kullman, S.W., and R.C. Hardman. Liver Toxicity. In

, The Toxicology of Fishes. Di Giulio, R.T. and D.E. Hinton, eds. CRC Press. Taylor and Francis Group. Boca Raton. Pages 327-400. 492a – f.

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225. 2008. Rotchell, J.M., Miller, M.R., Hinton, D.E., Di Giulio, R.T., and G.K. Ostrander. Chemical Carcinogenesis in Fishes. In R.T. and D.E. Hinton, eds. CRC Press. Taylor and Francis Group. Boca Raton.

, The Toxicology of Fishes. Di Giulio,

Pages 531.596. 226. 2008. Hardman R.C., Kullman, S.W., Yuen, B., Hinton, D.E. Non Invasive High Resolution In Vivo Imaging of α-napthylisothiocyanate (ANIT) Induced Biliary Toxicity in STII Medaka (Oryzias latipes). Aquatic Toxicology, 86(1):20-37. 227. 2008. Volz, D.C., Kullman, S.W., Howarth, D.L., Hardman, R.C. and D.E. Hinton. Protective response of the Ah receptor to ANIT – induced biliary epithelial cell toxicity in see-through medaka. Toxicological Sciences 102(2): 262-277. doi:10.1093/toxsci/kfm308. Advance Access Publication January 10, 2008. 228. 2008 Howarth, D.L., Law, S.H., Barnes, B., Hall, J.M., Hinton, D.E., Moore, L., Maglich, J.M., Moore, J.T. and Kullman, S.W. Paralogous VDRs in teleosts: transition of nuclear receptor function. Endocrinology 2008 Feb 7; [Epub ahead of print] PMID: 18258682. 229. 2008 Carney, M.W., Erwin, K., Hardman, R.C, Yuen, B., Volz, D.C., Hinton, D.E.,

Kullman, S.W. Differential toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos: a mechanistic study. Marine Pollution Bulletin 57

(2008) 255-266. 230. 2008 Hardman R.C., Kullman, S.W., and Hinton, D.E. Non Invasive In Vivo Investigation Hepatobiliary Structure and Function in STII Medaka (Oryzias latipes):Methodology and Applications. Comparative Hepatology 7:7; DOI 10.1186/1476-5926-7-7 231. 2008. Augspurger, T., Tillit, D.E., Bursian, S.J., Fitzgerald, S.D., Hinton, D.E., and Di Giulio, R.T. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the wood duck, Aix sponsa. Archives of Environmental Contamination and

Toxicology 55:659-669. 232. 2009 Padilla, S., J. Cowden, D.E. Hinton, B. Yuen, S. Law, S.W. Kullman, R. Johnson, R.C. Hardman, K. Flynn, and D.W.T. Au. Use of Medaka in Toxicity Testing. Current Protocols in Toxicology. Toxicological Models. Unit 1.10-1 - 1.10-36. 233. 2009 Hinton, D.E., R.C. Hardman, S.W. Kullman, J.M. Law, M.C. Schmale, R.B. Walter, R.N. Winn, and J.A. Yoder ( Eds.), Aquatic Animal Models of Human Disease: Selected Papers and Recommendations from the 4th Conference, Durham, NC, USA, January 31-February 3, 2008. Comparative Biochemistry and Physiology, Part C Volume 149. 234. 2009 Hinton, D.E., R.C. Hardman, S.W. Kullman, J.M. Law, M.C. Schmale, R.B. Walter, R.N. Winn, and J.A. Yoder. Editorial. Comparative Biochemistry and Physiology, Part C Volume 149: 121-128.

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235. 2010 Embry MR, Belanger SE, Braunbeck TA, Galay-Burgos M, Halder M, Hinton DE, Léonard MA, Lillicrap A, Norberg-King T, Whale G. The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research. Aquatic Toxicology 97(2): 79-87.

236. 2010 Howarth, D. L., Law, S.H.W., Law, M. H., Kullman, S.W., Mondon, J.A. and D.E. Hinton. "Exposure to the synthetic FXR agonist GW4064 causes alterations

in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)". Toxicology and Applied Pharmacology. Toxicology and Applied Pharmacology 243(1):111-121.

237. 2010 Howarth, D. L., Hagey, L., Law, S. H.W., Ai, N., Krasowski, M., Elkins, S.,

Moore, J., Hinton, D.E., and S. W. Kullman. Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquatic Toxicology 98(3):245-255.

238. 2010 Ding L, Kuhne WW, Hinton DE, Song J, Dynan WS. Quantifiable Biomarkers of Normal aging in the Japanese Medaka Fish (Oryzias latipes). PLoS ONE 5(10): e13287. doi:10.1371/journal.pone.0013287

239. 2010 Wills, L.P., Jung, D., Koehkrn, K., Zhu, S., Willett, K.L., Hinton, D.E., and R.T.

Di Giulio. Comparative chronic liver toxicity of benzo(a)pyrene in two populations of the Atlantic killifish (Fundulus heteroclitus) with different exposure histories. Environmental Health Perspectives 2010 May 25. [Epub ahead of print doi: 10.1289/ehp.0901799]

PUBLICATIONS IN PRESS 240. 2010 Bozinovic, G., Sit, T.L., Hinton, D.E. and M.F. Oleksiak. Gene expression throughout vertebrate embryogenesis. BMC Genomics. In Press. PUBLICATIONS SUBMITTED 241. 2010 Kwok, K.W.H., Weisner, M., Auffin, M. and D.E. Hinton. Toxicity of nanosilver to medaka early life stages. Environmental Science and Technology. PUBLICATIONS IN PREPARATION 242. 2010 Tosiano, M. Mondon, J.A., Kwok, K.W.H., and D.E. Hinton. Studies on the fate of the lipid vesicle in medaka early life stages.

PUBLICATIONS (LIMITED CIRCULATION) 1. 1996. Deanovic, L., Bailey, H., Shed T.W. and Hinton, D.E. Sacramento-San

Joaquin Delta bioassay monitoring report: 1993-94. First Annual

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Report. Central Valley Regional Water Quality Control Board, Sacramento, CA.

2. 1996. Bailey, H.C., Villalobos, A., Gottl, E., Brattin, L., Hanes, D., and

Hinton, D.E. Toxicity Study of the Santa Clara River, San Gabriel River and Calleguas Creek. Technical Report. Los Angeles Regional Water Quality Control Board. Montery Park, CA.

3. 1998. Deanovic, K., Cortright, K., Larsen, K., Bailey, H., Hinton, D.E., and

Connor, V. Guidelines for conducting toxicity identification Evaluation procedures in urban runoff- a laboratory manual. Technical Report. Central Valley Regional Water Quality Control Board. Sacramento, CA.

4. 1998. Deanovic, L., Bailey, H., and Hinton, D.E. Sacramento-San Joaquin Delta bioassay monitoring report: 1994-1995. Second Annual Report. Central Valley Regional Water Quality Control Board. Sacramento, CA. 5. 1998. Foe, C., Deanovic, L., and Hinton, D.E. Toxicity identification

evaluations of orchard dormant spray runoff. Technical Report. Central Valley Regional Water Quality Control Board. Sacramento, CA.

6. 1998. Larsen, K., Deanovic, D., Hinton, D., and Conner, V. Sacramento River Watershed program toxicity monitoring survey results: 1996- 1997. Technical Report. Central Valley Regional Water Quality Control Board. Sacramento, CA. 7. 1998. Larsen, K., Deanovic, D., Hinton, D., and Conner, V. Sacramento

River Watershed program toxicity monitoring survey results: 1997- 1998. Technical Report. Central Valley Regional Water Quality Control Board. Sacramento, CA 8. 1998. Larsen, K., Cortright, K., Connor, V., Youn, P., Deanovic, L, and

Hinton, D. Stockton fish kills associated with urban storm runoff: the role of low dissolved oxygen. Technical Report. Central Valley Water Quality Control Board. Sacramento, CA.

9. 1998. Marty, G.D., Hinton, D.E., Kocan, R.M., Hersberger, P., Winton, J.R., Kennedy, C.J. and Farrell, A.P. Investigations of disease factors

affecting declines of Pacific herring populations in Prince William Sound, Exxon Valdez oil spill restoration project annual report (Restoration Project 97162). Alaska Department of Fish and Game, Habitat and Restoration Division, Anchorage, Alaska.

ABSTRACTS

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1. 1968 Hinton, D.E. Spontaneous hepatic fibrosis associated with aging in four stocks of mice. Anat. Rec. 160:366.

2. 1969 Hinton, D.E. Ethanol induced hepatic stromal changes in C57B1 and DBA

mice. Anat. Rec. 163:199. 3. 1969 Smith, E.E., Parker, J.C. and Hinton, D.E. Intestinal enteritis and fluid loss

associated with hemorrhagic shock. Fed. Proc. 28:272. 4. 1967 Hinton, D.E. Spontaneous hepatic fibrosis with aging in four stocks of mice.

M.S. Thesis. 5. 1969 Hinton, D.E. Spontaneous and experimentally induced hepatic fibrosis in two

strains of mice. Ph.D. Dissertation. 6. 1970 Hinton, D.E. A comparison of age-dependent and induced hepatic fibrosis in

mice. Gerontol. 10:21. 7. 1972 Hinton, D.E. and Pool, C.R. Ultrastructural localization of acid

phosphatase in liver of channel catfish (Ictalurus punctatus). Anat. Rec. 172:331.

8. 1972 Pool, C.R. and Hinton, D.E. The fine structure of lipoprotein inclusion bodies in catfish liver. Proceedings of the 30th Annual Electron Microscopy Society of America Meeting. G.W. Bailey, Ed., Claitor's Publishing Division. Baton Rouge, pp. 262-263. 9. 1973 Hinton, D.E., Thurman, P.L. and Bidwai, P.P. Alteration in liver and kidney

of channel catfish following dietary administration of methyl mercury. J. of South Carolina Med. Assoc. 69:25.

10. 1975 Hinton, D.E., Heatfield, B.M. and Trump, B.F. Co-Carcinogenic effect of lead

and N-4-4', fluorobiphenyl acetamide in production of rat renal adenocarcinoma. Lab. Invest. 32:10-11.

11. 1975 Trump, B.F., Hinton, D.E., Dees, J.H., Heatfield, B.M. and Barrett, L.A.

Renal adenocarcinomas induced by N-4-4', fluorobiphenyl acetamide and their comparison with human renal adenocarcinomas. Lab. Invest. 32:22.

12. 1975 Heatfield, B.M., Hinton, D.E. and Trump, B.F. Enzyme histochemistry of renal adenocarcinoma induced in rats by N-(4' fluoro-4-biphenyl) – acetamide. Presented at Histochemical Society Meeting, Atlantic City, New Jersey, April, 12-13. 13. 1975 Trump, B.F., Hinton, D.E., Heatfield, B.M. and Barrett, L.A. Studies on the

histogenesis of renal carcinoma. Third Annual Collaborative Conf. NCI. Carcinogenesis program, Carlton House, Orlando, Florida, February 2-5.

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14. 1976 Hinton, D.E. and Glaumann, H. Electron microscopic and biochemical studies on the fatty liver produced by acute exposure to polychlorinated biphenyl (PCB) in the rat. Anat. Rec. 184:429.

15. 1976 Heatfield, B.M., Dees, J.H., Hinton, D.E. and Trump, B.F. Site of origin of

renal adenocarcinoma. XI International Congress, International Academy of Pathology, Washington, D.C., October 17-23, p. 116.

l6. 1977 Koch, T.R., Nipper, H.C. and Hinton, D.E. A new method for tissue cadmium

analysis employing differential pulse anodic stripping voltammetry. Presented at National Meeting of American Association for Clinical Chemistry.

17. 1977 Hinton, D.E., Klaunig, J.E. and Lipsky, M.M. PCB induced alterations in

teleost liver. A model for environmental disease in fish. Paper presented at Second Annual Eastern Fish Health Workshop. Easton, Maryland.

18. 1977 Hinton, D.E., Trump, B.F., Kasza, L., Weinberger, M.A., Friedman, L. and

Garthoff, L.H. Comparative toxicology of polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) in the rat liver. Light and electron microscopic alterations after subacute dietary exposure. Presented at International Symposium on Animals as Monitors of Environmental Pollutants. University of Connecticut, Storrs, Connecticut.

19. 1977 Lipsky, M.M., Klaunig, J.E. and Hinton, D.E. Effects of acute exposure to

PCB on the hepatic mixed function oxidative system of the channel catfish (Ictalurus punctatus, Rafinesque). A biochemical and ultrastructural study. Presented at International Symposium on Environmental Pollutants. University of Connecticut, Storrs, Connecticut.

20. 1979 Klaunig, J.E., Goldblatt, P.J., Hinton, D.E., Lipsky, M.M. and Trump, B.F.

Isolation and primary culture of mouse liver cells. Conference on Differentiation and Carcinogenesis in the Liver Cell Culture, New York Academy of Science, New York, New York, October 9.

21. 1980 Lipsky, M.M., Hinton, D.E., Klaunig, J.E. and Trump, B.F. A new

histochemical marker for carcinogen-induced premalignant and malignant hepatocellular alterations in mice. Presented at Annual Meeting of American Association of Cancer Researchers, Los Angeles, Calif.

22. 1980 Jones, R.T., Klaunig, J.E. and Hinton, D.E. Fish organ explants: A technique

for studying fish diseases. Presented at 5th Annual Eastern Fish Health Workshop, Leetown, West Virginia, June 17-19.

23. 1980 Kontir, D.M. and Hinton, D.E. Effect of Mn++ on in vitro BP(OH)ase activity

and on liver morphology in the rainbow trout (Salmo gairdneri). Presented at 5th Annual Eastern Fish Health Workshop, Leetown, West Virginia, June 17-19.

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24. 1980 Zuchelkowski, E.M., Pinkstaff, C.A., Lantz, R.C. and Hinton, D.E. Mucus

cells in epidermis of contro and acid-stressed brown bullhead catfish (Ictalurus nebulosus): A histochemical and morphometric study. Presented at 5th Annual Eastern Fish Health Workshop, Leetown, West Virginia, June 17-19.

25. 1980 Zuchelkowski, E.M., Pinkstaff, C.A. and Hinton, D.E. Mucous cells in

epidermis of control and acid-stressed brown bullhead catfish (Ictalurus nebulosus): A histochemical study. Anat. Rec. 196:79A.

26. 1980 Hinton, D.E., Lipsky, M.M., Klaunig, J.E. and Trump, B.F. Correlated

biochemical and morphological analysis of liver alterations in BALB/c mice during chronic safrole exposure. Anat. Rec. 196:79A.

27. 1980 Hinton, D.E. Morphologic alterations in teleost gill following acute exposure

to aqueous suspension of particulate Fe2 O3. Presented at 5th Annual Eastern Fish Health Workshop, Leetown, West Virginia, June 17-19.

28. 1980 Jones, G.S., Miles, P.R., Lantz, R.C., Hinton, D.E., Shreve, J.M. and Castranova, V. Effects of metallic ions on the oxygen consumption of isolated type II pneumocytes. Presented at 12th Annual Hanford Life Sciences Symposium "Coal Conversion and the Environment," Batelle Northwest, Richland, Washington, October. 29. 1981 Lantz, R.C. and Hinton, D.E. Alteration of lung structure by particulate

effluents from fluidized bed coal combustion: A morphometric study. Anat. Rec. 199:298.

30. 1981 Hinton, D.E., Walker, E.R. and Strohl, J.H. Manganese-induced alteration in

gill of fathead minnow (Pimephales promelas, Rafinesque): A light and electron microscopic study. Anat. Rec. 199:289-299.

31. 1981 Hinton, D.E., Lantz, R.C. and Zuchelkowski, E.M. Acid stress induced hyperplasia in skin of brown bullhead: A morphometric study. Presented at l2th Annual Conference of the International Association for Aquatic Animal Medicine, April, Mystic, Connecticut. 32. 1982 Lantz, R.C. and Hinton, D.E. Alteration in hamster distal lung following

exposure to fly ash from fluidized bed coal combustion: A morphometric study. Anat. Rec. 202:107A.

33. 1982 Jones, G.S., Miles, P.R., Lantz, R.C., Hinton, D.E. and Castranova V. Ionic

content and regulation of cellular volume in rat alveolar type II cells. Fed. Proc. 41:1601.

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34. 1983 Eacho, P.I., Brogan, W.C., Hinton, D.E. and Colby, H.D. Carbon tetrachloride (CCl4)-induced adrenal cortical necrosis in guinea pigs. Site of CCl4 activation. Toxicologist 3:104.

35. 1983 Lantz, R.C. and Hinton, D.E. Development of alteration in hamster distal lung

following exposure to fly ash from fluidized bed coal combustion: A morphometric study. Anat. Rec. 205(3):106A.

36. 1983 Zuchelkowski, E.M., Lantz, R.C. and Hinton, D.E. Cytogenesis of

acid-induced hyperplasia in epidermis of brown bullhead catfish Ictalurus nebulosus (Le Sueur). Second International Symposium on Responses of Marine Organisms to Pollutants. Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, April 24-26.

37. 1984 Kontir, D.M., Lantz, R.C. and Hinton, D.E. Ultrastructural morphometry of

rainbow trout (Salmo gairdneri) hepatocytes during 3 methylcholanthrene (3-MC) induction of MFOS. Mar. Environ. Res. 14:420-421.

38. 1984 Lantz, R.C., Hinton, D.E. and Burrell, R. The effect of inhaled bacterial

lipopolysaccharide (LPS) on pulmonary endothelium. 8th Cotton Dust Research Conference. Atlanta, Georgia, January 9-10.

39. 1984 Pisano, F., McCawley, M., Hinton, D.E., Stanley, C. and Lantz, R.C.

Evaluation of the concentration and size distribution of aerosols greater than 5 micrometers in the Hazleton animal exposure chamber. Coal Mine Dust Conference, Morgantown, West Virginia, October 8-10.

40. 1985 Hinton, D.E., Hampton, J.A. and Lantz, R.C. Morphometric analysis of liver

in rainbow trout: Quantitatively defining an organ important in xenobiotic metabolism. Presented at 3rd International Symposium on Responses of Marine Organisms to Pollutants. Plymouth, England, April 19-20.

41. 1985 Hampton, J.A., Lantz, R.C. and Hinton, D.E. The intrahepatic biliary system

of the rainbow trout liver: An enzyme histochemical and morphometric study. Presented at American Association of Anatomists meeting. Toronto, Canada, May.

42. 1985 Lantz, R.C., Burrell, R. and Hinton, D.E. Morphometric alterations in the lung

induced by inhaled bacterial endotoxin. Presented at Fourth European Society for Stereology. Gothenburg, Sweden, August 26-29.

43. 1985 Burrell, R., Lantz, R.C. and Hinton, D.E. The effect of inhaled bacterial

lipopolysaccharide (LPS) on the lung. Presented at 12th International Congress of Allergy and Clinical Immunology. Washington, D.C. October 20-25.

44. 1986 Holliday, T.L. and D.E. Hinton. Effect of diethylnitrosamine on development

of Pimephales promelas embryos. The Toxicologist 6(1):27.

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45. 1986 Hinton, D.E. Enzyme altered foci in medaka (Oryzias latipes) liver carcinogenesis. The Toxicologist 6(1):27.

46. 1986 Droy, B.F., Miller, E.R. and D.E. Hinton. Immunohistochemical utilization of

anti BrdU monoclonal antibodies as indicators of replication and DNA repair. The Toxicologist 6(1):222.

47. 1986 Hinton, D.E., Banks, M.A. and Martin, W.G. Effect of selenium

supplementation on histopathology of vitamin E deficiency in the Syrian golden hamster. Presented at the 70th Annual Meeting of the Federation of American Societies for Experimental Biology, St. Louis, Missouri, May.

48. 1986 Banks, M.A., Martin, W.G. and Hinton, D.E. Effect of vitamin E deficiency

on pancreatic tumors induced by N-nitrosobis (Z-oxopropyl) amine (BOP) in the Syrian golden hamster. Presented at the 70th Annual Meeting of the Federation of American Societies for Experimental Biology, St. Louis, Missouri, May.

49. 1986 Hinton, D.E., Holliday, T.L. and Lantz, R.C. Effect of diethylnitrosamine on

development of Pimephales promelas embryos. The Toxicologist 5. 50. 1986 Hinton, D.E., Holliday, T.L. Direct transchorionic embryonated egg exposure

in Pimephales promelas. Presented at National Institute of Environmental Health Sciences meeting "Mechanisms of Pollutant Action in Aquatic Organisms." Research Triangle Park, North Carolina, May 21-23.

51. 1986 Hinton, D.E., Holliday, T.L. and Lantz, R.C. Mechanism of pollutant action in

aquatic organisms. The Toxicologist Vol 6, pp 5. 52. 1986 Hinton, D.E. and Couch, J.A. Cytological changes during progression of

neoplasia. Toxic Chemicals and Aquatic Life: Research and Management. September 16-18, Seattle, Washington.

53. 1986 Hinton, D.E., Holliday, T.L., Giam, C.S. and Lantz, R.C. Bioassay of

groundwater contaminants using embryonated fish eggs. Presented at Joint Meeting of U.S. E.P.A. and West Virginia State Department of Fish and Game Conference. October 1986, Wheeling, West Virginia.

54. 1987 Stegeman, J.J., Miller, M.R. and Hinton, D.E. Immunohistochemical

localization of cytochrome P-450e in gill, heart, and liver of scup (Stenotomus versicolor). Presented at the 71st Annual Meeting of the Federation of American Societies for Experimental Biology, Washington, D.C., March, 1987.

55. 1987 Droy, B.F. and Hinton, D.E. Allyl formate-induced hepatotoxicity in rainbow

trout. Presented at the Fourth International Symposium on Pollutant Responses in Marine Animals. Woods Hole, Massachusetts, April 22-24, 1987.

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56. 1987 Hinton, D.E., Teh, S.J., Laurén, D.J. and Giam, C.S. Ultrastructural analysis of liver cellular alterations during diethylnitrosamine-induced neoplasia in Japanese medaka (Oryzias latipes). Presented at the Fourth International Symposium on Pollutant Responses in Marine Animals. Woods Hole, Massachusetts, April 22-24, 1987.

57. 1987 Miller, M.R., Hinton, D.E. and Stegeman, J.J. Immunocytochemical

localization of cytochrome P-450e in gill, heart, and liver of scup (Stenotomus versicolor) and rainbow trout (Salmo gairdneri). Presented at the Fourth International Symposium on Pollutant Responses in Marine Animals. Woods Hole, Massachusetts, April 22-24, 1987.

58. 1988 Holliday, T.L., Davis, M.E., and Hinton, D.E. Comparison of uptake and

distribution of diethylnitrosamine (DENA) in Oryzias latipes and Pimephales promelas. The Toxicologist 8(1):55.

59. 1988 Singh, Y., McEuen, S., Warren, D., Hinton, D. and Miller, M. Metabolism and lipid peroxidation in the trout and rat. Society for Toxicology 1988 Annual Meeting. 60. 1989 Parker, L.M., Laurén, D.J., Hinton, D.E. Substrate preferences and affinities

of cytosolic and microsomal aldehyde dehydrogenase in the liver of the rainbow trout. SETAC 10th Annual Meeting, November, 1989.

61. 1990 Parker, L.M., Hinton, D.E. The enhanced expression of phase I and phase II

enzymes in tumor containing liver of the rainbow trout (Oncorhynchus mykiss). International Society for the Study of Xenobiotics, San Diego, July, 1990.

62. 1991 Marty, G.D, Okihiro, M.S., Nunez, J. M. and Hinton, D.E. Morphology and

management of Mycobacterium avium infection in laboratory-reared medaka Oryzias latipes. 14th Annual AFS/FHS Meeting, 32nd Western Fish Disease Conference, Newport, Oregon, July 31 - August 3, 1991.

63. 1991 Parker, L.M., Hinton, D.E. and Laurén, D.J. Histochemical and biochemical

analysis of phase I and phase II enzymes in tumor containing liver of the rainbow trout, Oncorhynchus mykiss. Society of Environmental Toxicology and Chemistry 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

64. 1991 Bailey, H.C., Ostrach, D.J., Miller, M.J., Strella, T. and Hinton, D.E. Method

development and toxicity testing with the Korean prawn (Palaemon macrodactylus). Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

65. 1991 Ostrach, D.J., Bennett, W.A., and Hinton, D.E. Evaluating the starvation

hypothesis for larval striped bass using quantitative morphometric and histopathologic data. Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

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66. 1991 Lester, S.M., Braunbeck, T.A., Teh, S.J., Hinton, D.E., Stegeman, J.J. and

Miller,M.R. Immunocytochemical localization of cytochrome P450 IA1 in liver of rainbow trout (Oncorhynchus mykiss). Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

67. 1991 DeKoven, D., Nunez, J., Lester, S., Conklin, D., Marty, G., Parker, L. and

Hinton, D. A purified diet for medaka (Oryzias latipes) providing adequate and consistent nutrition for toxicologic research. Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

68. 1991 Hinton, D.E., Teh, S.J., Okihiro, M.S., Cooke, J.B. and Parker, L.M.

Phenotypically altered hepatocyte populations in diethylnitrosamine-induced medaka liver carcinogenesis: resistance, growth, and fate. Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

69. 1991 Hinton, D.E. Refinements on the medaka (Oryzias latipes) model enabling

analysis of environmental modulators of carcinogenesis. Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, Seattle, Washington, November 3-7, 1991.

70. 1992 Wolfe, M.F., Seiber, N. and Hinton, D.E. Establishing the utility of the larval

medaka bioassay for use in toxicity identification evaluations. Presented at Northern California Society of Environmental Toxicology and Chemistry, Oakland, California, May 29, 1992.

71. 1992 Hinton, D.E., Torten, M., Liu, Z., Teh, S.J., Okihiro, M.S., Bailey, H.A.

Genetic cellular and histologic biomarkers of diethylnitrosamine-induced hepatotoxicity in medaka (Oryzias latipes). Presented at Society of Environmental Toxicology and Chemistry, 13th Annual Meeting, Cincinnati, Ohio, November 8-12, 1992.

72. 1992 Gawlicka, A., Teh, S.J., Hung, S.S.O, de la Noüe, J., Hinton, D.E. Digestive

enzyme histochemistry of white sturgeon larvae during ontogenic development. 21st Fish Nutrition Workshop, 6-9 October, 1992, Davis, CA. pp. 14.

73. 1993 Wolfe, M.F., Villalobos, S.A., Seiber, J.N. and Hinton, D.E. A comparison of

carbamate toxicity to medaka (Oryzias latipes) embryos and larvae. Presented at Society of Toxicology Annual Meeting, New Orleans, Louisiana, March 14-18, 1993.

74. 1993 Bailey, H.C., DiGiorgio, and Hinton, D.E. Trends in the toxicity of

agricultural return waters to early life stages of striped bass (Morone saxatilis) and opossum shrimp (Neomysis mercedis). Western Wetlands Conference, University of California, Davis, March 25-27, 1993.

37

75. 1993 Wolfe, M.F., Seiber, J.N. and Hinton, D.E. Aqueous sample preparation for

bioassay using supercritical fluid extraction. Presented before the Division of Environmental Chemistry, American Chemical Society, Denver, Colorado, March 28-April 2, 1993.

76. 1993 Hinton, D.E., Teh, S.J. and Okihiro, M.S. Diethylnitrosamine-induced

hepatocarcinogenesis in a small, rapidly responding vertebrate. Joint Meeting of the European Association of Cancer Research and Abteilung Experimentelle Krebsforschung der Deutschen Krebgesellschaft, Heidelberg, Germany, April 19, 1993.

77. 1993 Bailey, H.C, Miller, M.J., Alexander, C.A. and Hinton, D.E. Trends in the

toxicity of agricultural return waters to early life stages of striped bass (Morone saxatilis) and opossum shrimp (Neomysis mercedis).

78. 1993 Wolfe, M.F., Villalobos, S.A., Seiber, J.N. and Hinton, D.E. A Comparison of Carbamate Toxicity to Medaka (Oryzias latipes) Embryos and Larvae Presented at the Seventh Annual Pollution and the Environment Meeting of the Royal Microscopic Society, Oxford, England, April 14-16, 1993. 79. 1993 Hinton, D.E., Teh, S.J., Okihiro, M.S. and Parker, L.R. Histo- and

Biochemical Cellular Markers for Hepatocarcinogenesis Studies in Medaka (Oryzias latipes) and Rainbow Trout (Oncorhynchus mykiss). Presented at the Seventh Annual Pollution and the Environment Meeting of the Royal Microscopic Society, Oxford, England, April 14-16, 1993.

80. 1993 Hinton, D.E., Bailey, H.A., Bennett, W.O. and Ostrach, D.J. Field and

Laboratory Investigations Involving Recruitment of Young-of-the-Year Striped Bass (Morone saxatilis). Presented at the Seventh Annual Pollution and the Environment Meeting of the Royal Microscopic Society, Oxford, England, April 14-16, 1993.

81. 1993 Gawlicka, A., Teh, S.J., Hung, S.S.O., de la Noüe, J. and Hinton, D.E.

Changements histoenzymologiques dans le tube digestif des larves d’Esturgeon blanc. 61e Congress of ACFAS. 17-21 May, 1993, Rimouski, Quebec. pp. 77.

82. 1993 Teh, S.J., Okihiro, M.S. and Hinton, D.E. Normal, regenerational, and

diethylnitrosamine-promoted hepatic growth in the medaka (Oryzias latipes). Presented at Eighty-Fourth Annual Meeting of American Association of Cancer Research, Orlando, Florida, May 19-22, 1993.

83. 1993 Gawlicka, A., Teh, S.J., Hung, S.S.O., de la Nouë, J., and Hinton, D.E.

Changements histoenzymologiques dans le tube digestif des larves d'esturgeon blanc, Acipenser transmontanus. The 61st Congress of the Fench-Canadian

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Association for the Advancement of Science, Rimouski (Quebec), May 17-21, 1993.

84. 1993 Hinton, D.E. Sacramento & San Joaquin Rivers, Delta and Northern San

Francisco Bay ecosystem: integrated, hydrodynamic modeling and toxicologic investigation as part of the center for ecological health research. Presented at the Northern California Society of Environmental Toxicology and Chemistry meeting, Sacramento, CA, May 21, 1993.

85. 1993 Hinton, D.E., Wilson, B.W., Bailey, H.C. Sacramento & San Joaquin Rivers,

Delta and Northern San Francisco Bay Ecosystem: Integrated, Hydrodynamic Modeling and Toxicologic Investigation as Part of the Center for Ecological Health Research. Presented at the Northern California Society of Environmental Toxicology and Chemistry meeting, Sacramento, CA, May 21, 1993.

86. 1993 Gawlicka, A., Teh, S.J., Hung, S.S.O., de la Noüe, J., Hinton, D.E.

Histological and histochemical changes in the digestive tract of white sturgeon larvae during ontogenic development. XV International Congress of Nutrition, 26 September - 1 October 1993, Adelaide, Australia. Book 2, pp. 653.

87. 1993 Gawlicka, A., Teh, S.J., Hung, S.S.O., de la Noüe, J., Hinton, D.E. Ontogenic

development of white sturgeon larvae: histology of the digestive tract and digestive enzyme histochemistry. Proceedings of the VI Int. Symp. on Fish Nutrition and Feeding. 4-7 October 1993, Hobart, Australia.

88. 1993 Hinton, D.E., Wilson, B.W., Fry, D.M. and Bailey H.C. Avian and Aquatic

Animals as Sentinels of Presence and Bioavailability of Pesticides. Presented at the Society of Environmental Toxicology and Chemistry, 14th Annual Meeting, Houston, Texas, 14-18 November, 1993.

89. 1993 Anderson, M.J., Miller, M.R., and Hinton, D.E. Cytochrome P450 1A

Inducing Compounds as Potential Inhibitors of Vitellogenesis in Fishes. Presented at the Society of Environmental Toxicology and Chemistry, 14th Annual Meeting, Houston, Texas, 14-18 November, 1993.

90. 1993 Villalobos, S.A., Hamm, J.T. and Hinton, D.E. Toxic effects of thiobencarb

(TBC) on medaka (Oryzias latipes) embryos. Presented at the Society of Environmental Toxicology and Chemistry, 14th Annual Meeting, Houston, Texas, 14-18 November, 1993.

91. 1993 Cooke, J.B. and Hinton, D.E. Tumor enhancement by 17- -estradiol and -

hexachlorocyclohexane in liver of medaka (Oryzias latipes). Presented at the Society of Environmental Toxicology and Chemistry, 14th Annual Meeting, Houston, Texas, 14-18 November, 1993.

92. 1993 Anderson, M.J., Miller, M.R., Gibb, T.L., Moussalli, M.J., Teh, S.J., Plopper,

C.G. and Hinton, D.E. Polycyclic aromatic hydrocarbon (PAH) interaction

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with isolated liver cells from medaka (Oryzias latipes): CYP 1A induction and Phase II response. Presented at the Society of Environmental Toxicology and Chemistry, 14th Annual Meeting, Houston, Texas, 14-18 November, 1993.

93. 1993 Bailey, H.C., Kroll, K., DiGorgio, C. and Hinton, D.E. Development of

procedures for identifying pesticide toxicity in effluents and ambient waters. Presented at workshop on Toxicity Identification Evaluation (TIE's) in the San Francisco Bay Region: Lessons Learned. Conducted by San Francisco Bay-Delta Aquatic Habitat Institute.

94. 1994 Bailey, H.C., DiGiorgio, C.L., Kroll, K., Hinton, D.E., Miller, J.L., and

Starrett, G. Procedures for identifying pesticide toxicity in effluents and ambient waters. Presented at Northern California Society of Environmental Toxicology and Chemistry.

95. 1994 Bailey, H.C., DiGiorgio, C. and Hinton, D.E. 1994. Trends in the toxicity of

agricultural return waters to early life stages of striped bass (Morone saxatilis) and opossum shrimp (Neomysis mercedis). In: Kent, D.M. and Zentner, J.J. eds. Western Wetlands, Selected Proceedings of the 1993 Conference of the Society of Wetland Scientists, Institute of Ecology, University of California, Davis, Ca, pp. 83-89.

96. 1994 DiGiorgio, C.L., Bailey, H.C., Clarke, J.C., Hinton, D.E., Costankos, S.,

Starrett, G. Toxicity of ambient waters collected from the Imperial Valley, CA. Presented at Northern California Society of Environmental Toxicology and Chemistry.

97. 1994 Reyes, E., Bailey, H., Hinton, D. and Connor V. The role of microorganisms and zinc in the Ceriodaphnia mortality observed in Sacramento River bioassays. NorCal SETAC annual meeting, Oakland, CA. 1994. 98. 1995 Washburn, B.S., Tullis, K., Baden, D.G. Rein, K., Walsh, P.J. Hinton, D.E. and Denison, M.S. Mechanism of induction of cytochrome P4501A by brevetoxin (PbTx), a polyether marine neurotoxin. Presented at Northern California Society of Environmental Toxicology and Chemistry. 99. 1996 Rogers, J.M., Chang, A., Hinton, D.E. and Washburn, B.S. Biomarkers for

oxidative stress in fish. Presented at Northern California Society of Environmental Toxicology and Chemistry.

100. 1996 Clark, S.L., Deanovic, L.A., Bailey, H.C., and Hinton, D.E. Toxicity

identification procedures for the freshwater algae, Selenastrum capricornutum. Presented at Northern California Society of Environmental Toxicology and Chemistry.

101. 1996 Hamm, J., Wilson, B.W., and Hinton, D.E. Mechanistic Studies of Diazinon

Toxicity in Early Life Stages of a Euryhaline Teleost, Medaka, (Oryzias

40

Latipes). From Cumulative Impacts Towards Sustainable Solutions: Critical Methodologies for the Study of Ecosystem Health. Center For Ecological Health Research, University of California, Davis, September 10-11, 1996.

102. 1996 Villalobos, S.A., Fan, T. W-M. , Higashi, R.M. and Hinton, D.E. “Exposures

of Medaka (Oryzias latipes” Embryos to Thiobencarb: Factors Modulating Embryo Toxicity.” From Cumulative Impacts Towards Sustainable Solutions: Critical Methodologies for the Study of Ecosystem Health. Center For Ecological Health Research, University of California, Davis, September 10-11, 1996.

103. 1997 Gawlicka, A., Leggiadro, C.T., Teh, S.J., O’Neil, D., Hinton, D.E., Gagnon,

D., Hung, S.S.O and de la Noüe, J. Enzyme histochemistry of white sturgeon larvae fed low and high protein diets. 24th Annual Meeting of Microscopical Society of Canada 24:104-105. University of Alberta, Edmonton, Canada 4-7 June 1997.

104. 1997 Clark, S.L., Deanovic, L.A., Connor, V.M., Bailey, H.C., Hinton, D.E., Miller,

J.L. and Miller, M.J. 1997. Toxicity identification evaluation procedures for the freshwater alga, Selenastrum capricornutum, exposed to urban runoff and agriculture drainage samples. SETAC 17th annual meeting, Washington, DC, November 17-21, 1997.

105. 1997 Foe, C., Croyle, W., Hinton, D. Mercury loading to the San Francisco Bay

Delta Estuary from the Sacramento watershed. Society of Environmental Toxicology and Chemistry. San Francisco, November 16-20, 1997.

106. 1997 Werner, I., Clark, S.L., Teh, S.J. and Hinton, D.E. Field validation of

biomarkers in Asian clam (Potamocorbula amurensis) collected along a contamination gradient in Northern San Francisco Bay. Society of Environmental Toxicology and Chemistry. San Francisco, November 16-20, 1997.

107. 1998 Werner, I., Kaufman R.C., Clark, S.L. and Hinton, D.E. Spatial and temporal

profiles of stress protein (hsp70) and metallothionein in Asian clam (Potamocorbula amurensis) in Northern San Francisco Bay. Poster presentation, SETAC 19th Annual Meeting, 15-19 Nov. 1998, Charlotte, NC.

108. 1999 Kullman, S.W. and Hinton, D.E. Identification of multiple isoforms of cytochrome P450 3A in medaka Oryzias latipes: characterizaion and ontogeny. Tenth Annual Symposium Pollutant responses in Marine Organisms (PRIMO), April 25-30, 1999, College of William and Mary, Williamsburg, VA.

109. 1999 Kullman, S.W., Erecius, L., Matsumura, F., Enan, E. and Hinton, D.E.

Estrogen signaling in trout liver: estrogen receptor and non-estrogen receptor mediated cellular response. Tenth Annual Symposium Pollutant responses in Marine Organisms (PRIMO), April 25-30, 1999, College of William and Mary, Williamsburg, VA.

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110. 1999 Koger, C.S., Teh, S.J. and Hinton, D.E. Determining the sensitive developmental stages of intersex induction in medaka (Oryzias latipes) exposed to 17 β-estradiol. Tenth Annual Symposium Pollutant responses in Marine Organisms (PRIMO), April 25-30, 1999, College of William and Mary, Williamsburg, VA.

111. 1999. Clark, S.L. and Hinton, D.E. Tissue and cellular alterations in Asian clam

(Potamocorbula amurensis) from San Francisco Bay: toxicologic indicators of exposure. Tenth Annual Symposium Pollutant responses in Marine Organisms (PRIMO), April 25-30, 1999, College of William and Mary, Williamsburg, VA.

112. 2000. Arukwe, A., S. W. Kullman, and D. E. Hinton.. Molecular cloning. characterization and expression of the eggshell zona radiata gene in Nonylphenol and Estrogen-treated Rainbow Trout (Oncorhynchus mykiss). Presented at the Society of Environmental Toxicology and Chemistry, World Congress. 113. 2001. Kullman, S.W., S. Kashiwada, and D.E. Hinton. 2001. Functional Characterization of medaka cytochrome CYP 3A38 and Cyp 3A40 by

expression in a recombinant baculovirus system. Presented at the Eleventh International Symposium on Pollutant Responses in Marine Organisms. July.

114. 2002. Kullman, S.W., S. Kashiwada, and D.E. Hinton. 2002. Functional

characterization of medaka cytochrome P450’s; role in endogenous ligand homeostasis and endocrine disruption. Presented at the Society of Environmental Toxicology and Chemistry. November 2002.

115. 2002. Hinton, D.E. Chemical Carcinogenesis in Fishes. Presented at the International

Symposium on Environmental Pollutants and their action. Minimata Japan. 116. 2002. Hinton, D.E., Use of see-through medaka in biomedical research with

emphasis on liver. Invited Speaker on occasion of retirement of Professor Kenji Ozato, Biosciences Center, Nagoya University, Nagoya, Japan.

117. 2002. Hinton, D.E. Chemical Carcinogenesis in Medaka. Presented at Department of

Biology, Dresden, Germany. 118. 2002. Hinton, D.E. The tubular architecture of liver of fishes. Invited Presentation in

special symposium on livers of lower vertebrates. 6th International Congress on Vertebrate Morphology, Jena Germany.

119. 2003. Kullman, S.W., S. Kashiwada, and D.E. Hinton. Analysis of medaka

cytpchrome P4503A heterotropic cooperativity: an alternate mechanism of endocrine disruption. Presented at the 12th International Symposium on Pollutant Responses in Marine Organisms.

120. 2003. Hinton, D.E. Imaging liver development and morphogenesis. International

Conference on Cells of the Hepatic Sinusoid. Tucson Arizona, August.

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121. 2004. Hinton, D.E. Use of medaka in carcinogenesis research – an synopsis. U.S.

Environmental Protection Agency, Environmental Research laboratory, Duluth, MN.

122. 2004. Hinton, D.E. Use of see-through medaka in liver toxicity research. Invited

Seminar, School of Pharmacy, University of Carolina, Chapel Hill. 123. 2004. Hinton, D.E. Use of see-through medaka in higher throughput research- the

nervous system. U.S. Environmental Protection Agency, Invited Seminar, Neurotoxicology Division, Human Health Effects Research Laboratory, RTP, NC.

124. 2005. Hinton, D.E. 2005. Detection of hepatobiliary toxicity, hepatocellular carcinogenesis and drug-induced toxicity in the see-through medaka. Invited Paper. International Symposium on Standardization of Medaka Bioresources. 13-16 November 2005, Noyori Conference Hall, Nagoya University, Nagoya, Japan. Paper was selected as best example of use of the see through medaka in environmental and biomedical research. 125. 2005. Hinton, D.E.*, Kullman,S.W., Volz, D.C., and R.C. Hardman.

Imaging Hepatic Toxicity in the See through Medaka (Oryzias Latipes). Third Aquatic Models of Human Disease Conference. University of Georgia, Athens, Ga, October 29 – November 2, 2005

126. 2005. Hardman, R.C., Hinton, D.E., Kullman, S.W. Non-invasive In Vivo Imaging of Hepatobiliary Structure and Function in a Unique Transparent Fish. Aquatic Models of Human Disease Conference. University of Georgia. Athens Ga, October 29 – November 2, 2005 125. 2005. Volz, D.C., Hinton, D.E., Law, J.M., Kullman, S.W. Dynamic gene expression changes precede dioxin-induced liver pathogenesis in medaka. Presented at the Society Environmental Toxicology and Chemistry. Baltimore, MD, November 13-17, 2005 128. 2005 Carney, M, Hinton, D. E. and Kullman, S. W. Differential toxicity of

naphthoic acid isomers in medaka (Oryzias latipes) embryos using a 96-well plate format. Presented at the Society Environmental Toxicology and Chemistry. Baltimore, MD, November 13-17, 2005

129. 2005. Chen, P.-J., Kullman, S. W. Hinton, D. E. Linden, K.G. Removal of

estrogenic activity from a mixture of endocrine disrupting compounds with UV/H2O2 oxidation treatment. Presented at the Society Environmental Toxicology and Chemistry. Baltimore, MD, November 13-17, 2005

130. 2005. Volz, D. C., D. E. Hinton, J. M. Law, and S. W. Kullman. 2005. Detection of

alphanaphthylisothiocyanate – induced biliary toxicity in the adult see-through medaka (Oryzias latipes). Third Aquatic Models of Human Disease

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Conference. University of Georgia, Athens Ga, October 29 – November 2, 2005

131. 2005. Rocha, E., Marcos, R., Galante, M.H., Monterio, R.A.F. and D. E. Hinton. Preneoplastic foci and benign neoplasms in brown trout liver – Induction by MNNG and promotion by estradiol and alkylphenols. Presented at the13th Intl. Meeting of Pollutant Responses in Marine Organisms. Italy.

132. 2006. Oxendine, S., D. E. Hinton, J. Cowden, and S. Padilla. Developmental effects of ethanol in the Japanese medaka fish (Oryzias latipes): Windows of vulnerability. Neurotoxicology

27(5): 925-925.

FUNDING RECORD-COMPLETED AND CURRENT PROJECTS 1. 1971-1973 Enzyme and Tissue Alterations in Fishes: A measure of water quality. $18,000/ year. Department of the Interior, Office of Water Resources Research. Role, Principal Investigator. 2. 1976-1980 Biology of Liver Neoplasms in the Mouse. N.C.I. Contract #N0l CP 95762-69. $240,000 total direct costs. Renewed for one additional year. Role, Co-Principal Investigator. 3. 1977-1979 Grant #E.P.A.R-804866-01-0; Detection of Mutagenic/Carcinogenic Alteration in Fish and its Application to Human Health, $110,000. Role, Principal Investigator. 4. 1977-1980 Cellular Bioassay of Fish: A Sensitive Measure of Water Quality Related to Mine Water. $39,000. Department of Interior, Office of Water Resources Research. Role, Principal Investigator. 5. 1978-1982 Microscopic Anatomy of Key Freshwater Fish Species. United States Fish and Wildlife Service Contract #14-16-0009-042. $70,000. Role, Principal Investigator. 6. 1980-1982 Effects of Effluents of Coal Combustion and Gasification on Lung Structure and Function, $163,000.00. Department of Energy Morgantown Energy Technology Center. Role, Principal Investigator. 7. 1980 Non-invasive In Vivo Microscopic Detection of Hepatic Neoplasia in Aquarium Fishes. $5,000.00. American Cancer Society, Institutional Grant. Role, Co-principal Investigator. 8. 1980-1983 Cellular Bioassay of Fish as a Sensitive Index of Water

44

Quality Related to Ash from Coal Combustion, $35,000.00. Department of Interior, Office of Water Resources Research. Role, Principal Investigator. 9. 1982-1986 Evaluation of Endotoxin as an Injurious Component of Cotton Dust. $36,000.00 annual support. Cotton Research Incorporated. Role Co-principal Investigator with Drs. Robert R. Burrell and R. Clark Lantz. 10. 1983-1984 U.S. Department of the Interior, Geological Survey, Water Resources Division."Effects of Fe++ in Streams on Gill Morphology, O2 Consumption and Phytoplankton/Benthic Invertebrate Distribution." $115,000.00 total support. Role, Co-principal Investigator with Dr. Ed Keller. 11. 1983-1985 U.S. Environmental Protection Agency. "Enzyme Altered Foci in Fish Liver Carcinogenesis." CR-811017-01-1. $80,000.00 total support. Role, Principal Investigator. 12. 1983-1987 U.S. Department of the Interior, Bureau of Mines. Pennsylvania State University and West Virginia University Generic Center for Research on Respirable Coal Mine Dust. R.l. D2/WV5. "Pulmonary Inhalation Toxicity of Respirable Coal Mine Dusts: A Morphometric Study." Award Amount – $94,980. Role, Co-Principal Investigator. 13. 1984-1987 National Science Foundation. "Functional Units in Teleost Liver." Award Amount - $251,000.00. Role, Principal Investigator. 14. 1985-1987 U.S. Department of the Interior, Geological Survey, Water Resources Division. "Bioassay of Contaminated Ground Water Using a Fish Embryo Toxicity Test." Award Amount – $40,000. Role, Principal Investigator. 15. 1985-1990 National Institute of General Medical Sciences, National Institutes of Health. Graduate Training in Pharmacological Sciences. 5-T32-MG 07039-09. Role, Participating Faculty (Aquatic Toxicology). Department of Pharmacology and Toxicology, West Virginia University. 16. 1992-2002 United States Environmental Protection Agency, U.C. Davis "Center for Ecological Health Research." EPA #CR819658- 010. $30,000/yr. Role- Participating Faculty, Leader for Sacramento River, Delta and Upper San Francisco Bay Ecosystem. 17. 1986-2000 National Institutes of Health, National Cancer Institute. "Cell

45

and Matrix Biology of Fish Liver Carcinogenesis." 1 RO1 CA45131. Total award first 5 years $1,084,598. Competitively renewed for one three year and one five year period at similar funding level. Role- Principal Investigator. 18. 1992-2000 National Institute of Environmental Health Sciences. "Postdoctoral Training Grant in Environmental Pathology." #2-T32-ESO 7055, P.I. Dennis W. Wilson. Role, Co- investigator participating faculty mentor for three postdoctoral students. 19. 1987-1998 National Institute of Environmental Health Sciences. "Environmental Toxicology Training Grant." 5-T32-ESO7059. P.I. Dennis P.H. Hsieh and Robert R. Rice. Role, Co- investigator. 20. 1988-2004 National Institutes of Health, National Institute of Environmental Health Sciences. Superfund Basic Research Program. "Biomarkers of Exposure to Hazardous Substances: Genotoxicity Screening of Chemical Wastes." 2P42 ESO 4699-14. Average annual support $87,714.00. Role, co-investigator, project #2. 21. 1989-1994 U.S. Army Biomedical Research and Development Laboratory. Fort Detrick. DAMD 17-90-C-0003. 5 year award. "Dietary Refinements in a Sensitive Fish Liver Tumor Model." Total Award $239,748.00. Role- Principal Investigator. 22. 1992-1994 Martin Marietta Energy Systems, Inc., for U.S. Department of

Energy. "Histopathologic and Morphometric Determinations in Fish Liver." 19X-SC878V. 10/1/92 - 9/30/94 $85,000.

23. 1993-1996 USDA, Western Regional Aquaculture Consortium. #332033, Project 3D. "Effects of broodstock nutrition on maturation and subsequent reproductive performance of salmonids." $30,000.00/yr. Renewed for 1 additional year at $14,000. Role Principal Investigator. 24. 1992-1994 Department of Fish & Game. State of California. "Fish & Game Bay Protection & Toxic Cleanup Program." #1-165-250-0. Total support $205,827. Role- Principal Investigator. 25. 1992-1994 State of California, Water Quality Control Board. "Evaluation of Health of Striped Bass Larvae in Suisun Marsh, Sacramento and San Joaquin Rivers, California." $205,000.00. Role- Principal Investigator. 26. 1991-1993 State of California, Water Resources Control Board. "Toxicity of

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the Colusa Basin Drain (CBD) to Striped Bass (Morone saxatilis) larvae." #1-050-250-0. $100,000. Role- Principal Investigator. 27. 1992-1994 State of California, Water Resources Control Board. "DWQ Project." $178,000. Role-Principal investigator. 28. 1991-1992 State of California, Water Resources Control Board. “Investigation into the extent, nature, and source of toxicity from agriculture in high-priority waters in the Colorado River Basin.” $268,000.00 and administratively continued through 3/31/94. Role- Principal Investigator. 29. 1992-1994 State of California, Water Resources Control Board. "Master Contract." #2-088-250-0, $234,500.00. Role- Principal Investigator. 30. 1992-1994 State of California Regional Water Quality Control Board: Los Angeles Region. "Development of Site-Specific Objectives for Two Effluent Dominated Streams: Santa Clara and San Gabriel Rivers." #1-085-254-0. $240,000.00. Role- Principal Investigator. 31. 1992-1993 State of California Regional Water Quality Control Board: Region 8. "Newport Bay Watershed Stormwater and Nuisance Water Management Program." #1-146-258-0. $56,000.00. Role- Principal Investigator. 32. 1992-1993 State of California Regional Water Quality Control Board: Santa Ana Region. "Chronic Toxicity Bioassays of Big Bear Lake and its Surrounding Watershed." #1-007-180-0. $36,000.00. Role- Principal Investigator. 33. 1992-1993 State of California Regional Water Quality Board: Anaheim Bay Project. "Chronic Toxicity Bioassays of inland Surface Waters in the Santa Ana Region." #1-153-258-0. $36,000.00. Role- Principal Investigator. 34. 1992-1993 State of Alaska, Department of Fish and Game. "Histopathologic Services in Support of Investigations of Long-term Effects of the Exxon Valdez Oil Spill." #IHP-93-016. $30,000.00. Co Investigator with Gary D. Marty, PhD. 35. 1993-1995 State of California State Water Resources Control Board. "Biomarker type field toxicity investigations." #1-165-250-0. $180,000/year. Role- Principal Investigator. 36. 1994-1995 Martin Marietta Energy Systems, Inc., for U.S. Department of Energy. "Histopathological Analysis of Cape Cod Fish Tissue." 6/1/94 - 5/31/95. $75,000. Role- Principal Investigator.

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37. 1993-1994 California Department of Fish & Game. "Goby Biomarker/Inland Bay Protection and Toxic Cleanup Program." #FG2305ES. $40,000.00. Role- Principal Investigator. 38. 1994-1995 State of California, Water Resources Control Board. "Master Contract" #3-117-250-0, $90,000.00. Role- Principal Investigator. 39. 1994 Alaska Department of Fish & Game. "Disease Impacts on Prince William Sound Herring Populations." #94320-S. $75,000. Role- Co Investigator with Gary D. Marty, DVM. 40. 1995-1996 United States Department of Commerce, National Oceanographic and Atmospheric Administration, Contract #43ABNF501457. “Determine Extent of Histopathological Lesions in Pacific Herring Adults Exposed to Petroleum Hydrocarbons.” $12,475. Role, Co -Investigator with Gary D. Marty DVM. 41. 1994-1996 State Water Resources Control Board, #105329V. Toxicity Testing. $195,000.00. Role- Principal Invetigator. 42. 1995-1998 U.S. Environmental Protection Agency. #R823297-01-0. “Linkage of Stress Proteins and Toxic Alterations: a Laboratory and Field Investigation.” Total support- $474,658. Role- Co Principal Investigator with Brenda Sanders PhD. 43. 1996-1999 U.S. Environmental Protection Agency. #R825298-10-0. “An in vivo model for detection of reproductive effects of endocrine disruptors. Total award $581,753.00. Role- Principal Investigator. 44. 1996-2000 University of California, System-wide Ecotoxicology Lead Campus Graduate Training Program. Annual support- $250,00 (year 1), $200,00 (year 2), $300.00 (years 3-5). Role- Program Director. 45. 1996-1998 State of California, Water Resources Control Board. UC Davis Agreement #96-0883227V “Pesticide Runoff.” $163,750.00. Role- Project Director. 46. 1996-1997 Sacramento Regional County Sanitation District #80499. UC Davis Agreement #96-08319V “Wastewater Monitoring, Consulting” $100,000.00. Role- Project Director. 47. 1997-1999 State Water Resources Control Board. “Agricultural Management Practices Contract”. $130,000. Role- Co- Investigator. 53. 1998-2000 Calfed Bay-Delta Program. B211. "Alternative Practices For Reducing Pesticide Impacts On Water Quality." $ 243,000. Role- Co- Principal Investigator.

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54. 1997-1999 County of Yolo, Dept. of Health/SWRCB. "Cache Creek and Putah Creek Management Plan." $ 93,062.00. Role- Project Director. 55. 1998-2000 Sacramento Water Regional Control Board “Surface Waters Toxicity Testing of Inland Waters in the Central Valley, Imperial Valley and in Ventura County.” $97,500.00. Role- Project Director. 56. 1997-1998 State Water Resources Control Board. UCD Agreement #97 -10831V “Conduct toxicity testing on Central Valley watershed with potential codling moth including Sacramento, San Joaquin Delta Estuary, Yolo County irrigation tail water ponds and Revolon Slough.” SWRCB #6-066-2500. $153,000.00. Role- Project Director. 57. 2000-2002 North Carolina Biotechnology Center. Start up equipment for David E. Hinton, Nicholas Professor, Duke University. $150,000.00. 58. 2001-2003 NCBC 2001-ARG-0030 S. W. Kullman (PI) Hinton was CO-PI. North Carolina Biotechnology Center. Academic Research Initiation Grants Program. Toxicant Induced Differential Gene Expression and Production of an Aquatic Gene Microarray Array. 59. 2005-2006 1900-0003-17/WRRI S. W. Kullman (PI) Hinton (co-pi) Water Resources Research Institute. Bioanalytical Analysis and Reproductive Effects of Environmental Endocrine Disruptors at Concentrated Animal Feed Operations Affecting North Carolina River Waters 60. AWWARF #2897 K. G. Linden (PI) 12/01/02-08/30/05 American Water Works Association Research Foundation Impact of UV and UV Advanced Oxidation Processes on Toxicity of Endocrine Disrupting Compounds in Water 01/01/06-07/01/06 Project Continuation Reserve Proposal Kullman Role (Co-PI) Hinton Role (investigator) Application of in vivo and in vitro bioanalytical assays for assessment of endocrine mediated toxicity following enhanced photochemical degradation of contaminated surface, drinking and STP finish waters. 61. P42 ES10356-10 R. T. Di Giulio (PI) Hinton (investigator- project 6) 04/01/05-3/31/09 NIH/NIEHS Duke University Superfund Basic Research Center. 62. WERF 01-HHE-21T S.W. Kullman (PI) D.E. Hinton (co-PI) 05/15/02-01/15/06 Water Environment Research Foundation. “Innovative DNA Array Technology for Detection of Pharmaceuticals in Aquatic Environments”.. Establish and employ a differential gene expression tools including subtractive hybridization and microarray analysis to identify exposure and effects of PPARα agonists in aquatic environments.

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63. RO1 RR18583 D.E. Hinton (PI) 08/08/03-05/30/07 NIH/NCRR Enhanced Image Analysis of a Transparent Fish Model. Role: (Co-PI). Establishing specific molecular imaging technologies to study organ system growth and development in the see through medaka and enhance this models potential to study effects of hepatic architecture and gene function for assessment of environmental and human disease. 64. R21CA106084-01A1 S.W. Kullman (PI) D.E. Hinton (mentor) 08/01/04-07/30/06 NIH/NCI. In vivo Transgenic Reporter for Hepatobiliary Toxicity. Role: (PI) Development of an in vivo transgenic reporter system for screening hepatobiliary toxicity during pharmaceutical development. 65. Duke University Comprehensive Cancer Center S. W. Kullman (PI) 01/01/06-12/31/07 Membrance Initiated Steroidal Signaling: A Potential Novel Mechanism for Xenobiotic Induced Tumor Promotion. Role: D.E. Hinton is Investigator on this grant. Pilot project for DCCC to investigate the role of the membrane associated tyrosine kinase receptor ERBB2 activation by xenoestrogens in breast cancer promotion. 66. Duke University Comprehensive Cancer Center Yin-Xiong, Li (PI) 01/01/06-12/31/07 Zebrafish model of hepatocarcinogenesis. Role: D.E. Hinton is co-PI. Pilot project for DCCC to investigate the role of hepatic stem cells in carcinogenesis. Work will integrate medaka and zebrafish strengths. Other Investigators include Anna Mae Diehl, M.D. – Chief of Gastroenterology – Duke University. 67. Duke University Comprehensive Cancer Center “SELENIUM EXPOSURE, DNA METHYLATION, AND MAMMARY CARCINOGENESIS” 01/01/06-12/31/07. Two questions are to be investigated: 1 “Does selenium exhibit complex interactions with dietary compounds (folate) and environmental agents (arsenic) that affect DNA methylation?” and 2 “Does the dose and/or timing of selenium exposure determine the ability of selenium to either prevent or promote breast cancer?” Victoria Seewaldt, M.D.; David Hinton, Ph.D.; Randy Jirtle, Ph.D.; Seth Kullman, Ph.D.; and Robert Cardiff, M.D., Ph.D. are the team members.

68. WERF 01-HHE-4A (Schlenk) (PI)

07/01/03-01/31/06 10%. Water Environment Research Foundation “Use of Japanese medaka as an on-line Screening Platform for the Evaluation of Potable Water” Role: Co-PI

69. 1P42 ES 10356-02 Di Giulio & Slotkin 4/01/05 – 3/31/10 NIEHS Superfund Chemicals Impact on Reproduction and Development. Co-Investigator in Project 6. 10%

70. EF-830093. (Wiesner, PI; Hinton, Investigator in Project 2, 10% effort)

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10/01/08-09/13/13. NSF and U.S. EPA Center for the Environmental Impacts of Nanotechnology.

TEACHING EXPERIENCE 1. 1967-196 9 Department of Anatomy, University of Mississippi, Medical Center, Jackson, MS. Laboratory Instructor in Human Gross Anatomy 2. 1969-1973 Department of Anatomy, University of Louisville, School of Medicine, Louisville, KT. Human Gross Anatomy for medical Students 3. 1973-1974 Department of Pathology, University of Maryland, School of Medicine, Baltimore, MD Selected lectures in cell injury to sophomore medical students and residents 4. 1975-1976 Department of Pathology, University of Maryland, School of Medicine, Baltimore, MD Coordinator of Pathology Education 5. 1977-1986 Department of Anatomy, West Virginia University, School of Medicine, Morgantown, WV Developmental and Gross Anatomy for medical students (Primary responsibility: Embryology, Abdomen, Pelvis/Perineum) 6. 1978-1986 Department of Pathology, West Virginia University, School of Medicine, Morgantown, WV Lectures on Cell Injury and on Chemical Carcinogenesis 7. 1978-1986 Department of Pharmacology and Toxicology, West Virgina University, School of Medicine, Morgantown, WV Lectures on Carcinogenesis, Toxicity of Chlorinated Biphenyls, and Morphological Assessment of Toxicity 8. 1987-1992 Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA Aquatic Animal Medicine (VM416). Lectures on: Physiology and Anatomy of Fishes, Environmentally-Induced Diseases of Fishes, Nutritional Diseases and Neoplasms in Fishes. 9. 1987-1988 Deparment of Pharmacology and Toxicology, School of Veterinary

Medicine, University of California, Davis, CA Veterinary Toxicology (VM410). Aquatic Pollutants and Their Effects

10. 1988-2000 Department of Pharmacology and Toxicology, School of Medicine, University of California, Davis, CA (VMD414C) “Aquatic Toxicology.” 11. 1988 Toxicology Graduate Group. University of California, Davis, CA

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(PTX 290) Graduate Seminar on Aquatic Toxicology 12. 1988-1992 Department of Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA Veterinary Toxicology-Advanced Course (VDM410) “Water Pollution and Toxicants.” 13. 1988-2000 Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA (VTP253) “Metabolism-Xenobiotic-Biotransformation Reactions in Fish. One Lecture Every Other Year 14. 1990 Department of Surgery, School of Veterinary Medicine, University of California, Davis, CA (SVM291) Anesthesia/Critical Patients Care. Basic Science Program. One Lecture on Anesthesia in Fish. 15. 1990-2000 Department of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California, Davis, CA (APC220; formerly PHC220). One Lecture on Liver Structure. 16. 1990, 1992 Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA (VTP247). Natural Toxicants. Lectures on Saffrole. 17. 1990-2000 Department of Environmental Toxicology, School of Agriculture and Environmental Sciences, University of California, Davis, CA. (ETX240). Undergraduate Ecotoxicology. Two Lectures per Year on “Aquatic Toxicology.” 18. 1991- 1992 Department of Applied Behavioral Science, Community Studies and Development, University of California, Davis, CA. Laboratory on Aquaculture/Embryo Development during the 1991 and 1992 University of California, Davis Summer Science Instititute. 19. 1992 Department of Surgery, School of Veterinary Medicine, University of California, Davis, CA (SVM293) Anesthesia/Critical Patients Care. Basic Sciences Program. Lecture on Anesthesia in Fish.

20. 1992-2000 Graduate Group in Pharmacology and Toxicology, University of California, Davis. (PTX 203) Environmental Toxicology, Block III - Environmental

Toxicology, Risk Assessment and Epidemiology. Lecture on "Toxicity to Aquatic Systems and Aquatic Toxicity Testing."

21. 1994-2000 Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis. (APC 100) Advanced Undergraduate Course. Lectures (7) and Labs (3) each year on Digestive and Urinary Systems. 22. 1995-2000 Department of Environmental Toxicology, University of California, Davis.

(ETX 101). Principles of Environmental Toxicology. Lecture on Aquatic

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Toxicology. 23. 1995-2000 Department of Environmental Toxicology, University of California, Davis. (ETX 240). Ecotoxicology. Two lectures on Aquatic Toxicology. 24. 1995 Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis. (VMD 432) Normal GI and Mammary Gland Systems. Four lectures and four labs. 25. 1995-2000 Department of Medicine and Epidemiology, School of Veterinary

Medicine, University of California, Davis. (VMD 432) Normal GI and Mammary Gland Systems. Four lectures and four labs.

26. 1995-2000 Department of Anatomy, Physiology and Cell Biology, School of

Veterinary Medicine, University of California, Davis. (APC 220/420). Physiology and Pathophysiology of the Anatomy and Histology of the Liver. Lecture on Anatomy and Histology of the Liver.

27. 1995-2000 Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis. (VMD 414C). Veterinary Toxicology. Lecture on Aquatic Toxicology 28. 1996-2000 Department of Anatomy, Physiology and Cell Biology, School of

Veterinary Medicine, University of California, Davis. (VMD 432) Normal GI and Mammary Gland Systems.

29. 1996-2000 Course leader ECL 290 “Ecotoxicology Seminar Series.” 30. 1998-2000 Course leader PTX 230 “Perspectives in Aquatic Toxicology.” 31. 2002-Present Course leader ENV 274 “Seeing the Big Picture: Lessons from Watershed Management in California. Nicholas School of the Environment Duke University. Usual enrollment is 9-15 MEM students and 1-2 undergraduates. 32. 2003- Present Course Leader ENV 298.60. “Integrative and comparative pathobiology for toxicologists.”Nicholas School of Environment, Duke University. Usual enrollment is 4-5 PhD students and 1-2 MEM students.Course concerns various animal models, REACH EU legislation and use of animals in research. 33. 2007- Present Duke Environmental Leadership. “Seeing the Big Picture: Lessons from Watershed Management in California. Nicholas School of the Environment Duke University. 10 Midcareer professionals take this course each year. We use web-based instruction and two 4 hour encounters face to face. 34. 2004-Present Presentation of two lectures each year in Environmental Chemistry and Toxicology ENV 160. 35. 2005-Present Team instructor in “Natural Catastrophes: Response and Repair” co-

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taught with David Schaad of School of Engineering. 36. 2005 – Present Offer individual instruction when requested. Have completed 2, 3 hour credit courses for MEM Students. 37. 2007-2008 Mentor for James Wong undergraduate student. Research and Final paper preparation. 38. 2009- Present Environmental Management ENV 302. Team taught with 7 faculty

and 160 MEM Students. INVITED SPEAKER AND RESEARCH RELATED ACTIVITIES 1. 1972 American Society of Testing and Materials. Symposium on Biological

Monitoring of the Aquatic Environment, Los Angeles, California, June 19, 1972. Use of histological and histochemical assessments in the prognosis of the effects of aquatic pollutants.

2. 1973 Environmental Protection Agency. Workshop on Role of Histopathology

in Aquatic Pollution Studies. Gulf Breeze, Florida, May, 13-16, 1973. Acute and subacute methyl mercury-induced alteration in channel catfish.

3. 1974 Virginia Polytechnic Institute and State University, Center for

Environmental Studies, Blacksburg, Virginia, March, 1974. Morphologic studies of pollutant-induced alteration in fresh-water fish species.

4. 1975 Department of Cell Biology, University of Jyvaskyla, Jyvaskyla, Finland, May, 1975. Environmental pathology related to fishes. 5. 1975 Zoologisches Institute, University of Salzburg, Salzburg, Austria, July,

1975. Aquatic pollution and fish toxicopathology. 6. 1977 Baltimore-Washington Chapter of American Association of Clinical

Chemists, Baltimore, Maryland, April, 1977. Environmental pollutants: Hazards and mode of action.

7. 1977 Department of Health, Education and Welfare Public Health Service,

Food and Drug Administration, Washington, D.C., May, 1977. Pharmacology - Toxicology Seminar, Comparative Toxicology of Polychlorinated biphenyl (PCB) and polybrominated biphenyl (PBB) in rat liver: Light and electron microscopic observations.

8. 1977 Second Annual Meeting, Easton Fish Health Workshop, Easton, Maryland, May,

1977. PCB induced alterations in telost liver: A model for environmental disease in fish.

9. 1977 Environmental Pathology Lectures in Sophmore Pathology Course, University of Maryland, School of Medicine, Baltimore, Maryland, September, 1977.

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10. 1977 Environmental Pathology Lectures, Department of Pathology, University de Calais, Calais, Puerto Rico, October, 1977.

11. 1978 National Cancer Institute, Division of Toxicology, Bethesda, Maryland, June,

1978, Studies of PCB toxicity in liver of fish and rat.

12. 1978 Environmental Protection Agency International Workshop on Polycyclic Aromatic Hydrocarbons in the Marine Environment, Gulf Breeze, Florida, August, 1978.Chemical carcinogenesis in fish: Induction of hepatic drug metabolizing enzymes and bacterial mutagenesis with polycyclic aromatic hydrocarbons (PAH).

13. 1978 Lectures on Cell Injury, Department of Pathology, West Virginia University, School of Medicine, September, 1978.

14. 1979 Interagency Collaborative Group on Environmental Carcinogenesis, H.F. Kraybill,Ph.D., Program Chairman, Bethesda, Maryland, January 10, 1979. Chemical carcinogenesis studies in fish: Comparison to mammalian systems.

15. 1979 Consulting participant in Pennsylvania State University - Environmental Protection Agency Project "Evaluation of Current Environmental Research and Establishment of Priorities." Member of work group on carcinogenesis and immunological effects, April, 1979.

16. 1979 Environmental Pathology Lectures in Sophomore Pathology Course, Medical

College of Ohio, Toledo, Ohio, May, 1979.

17. 1979 Fourth American Society for Testing and Materials (ASTM). Symposium on Aquatic Toxicology. Chicago, Illinois, October, 1979.

18. 1980 Environmental Pathology Lecture, Sophomore Pathology Course, Medical College of Ohio, Toledo, Ohio, May, 1980.

19. 1980 Consultant to Environmental Protection Agency, Division of Pesticide

Toxicology, 1980.

20. 1980 West Virginia University Cancer Teaching Days, Department of Surgery, April

11,1980. Microscopic and gross anatomical features of developing and adult

colon.

21. 1981 Environmental Protection Agency/National Cancer Institute Workshop on "Use

of small aquarium fishes in carcinogenesis research." Bethesda, Maryland, December 7-9,1981.

22. 1982 National Oceanographic and Atmospheric Administration and Environmental Protection Agency Workshop, "Meaningful Measures of Marine Pollution Effects."Pensacola, Florida, April 25-29, 1982. Pathobiological measures of marine pollution effects.

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23. 1984 United States Army, Biomedical Engineering, Environmental Assessment

Branch, The Japanese medaka liver tumor model: new findings and review of literature. Ft. Detrick, Maryland, January 18-20, 1984.

24. 1984 Research Seminar, “Enzyme altered foci in liver carcinogenesis.” U.S. Environmental Protection Agency, Gulf Breeze, Florida, March 10, 1984.

25. 1984 National Cancer Institute, National Institute of Health, Invited Participant in “Workshop on Fish Neoplasia.” Bethesda, Maryland, December 12-14, 1984.

26. 1985 Institute for Marine Environmental Research, Plymouth, England. Third International Symposium on Responses of Marine Organisms to Pollutants. April 17-19, 1985. "Morphometric Analysis of Liver in Rainbow Trout: Quantitatively Defining An Organ Important in Xenobiotic metabolism."

27. 1985 United States Environmental Protection Agency, Region III Biology Workshop. April, 1985. "An overview of Fish Carcinogenesis: Rationale and Approaches to Sampling Feral Populations."

28. 1985 United States Department of the Interior, Fish and Wildlife Service. Special Consultant. Determination of criteria for establishing Cancer Injury in Fishes and Wildlife. Washington, D.C., May 19-23, 1985.

29. 1986 National Institute of Environmental Health Sciences. Symposium on

"Mechanisms of Pollutant Action in Aquatic Organisms." May 21-23, 1986. Research Triangle Park, North Carolina. "Normal versus abnormal structure: Considerations in morphologic responses of teleosts to pollutants."

30. 1986 National Oceanic and Atmospheric Administration, Environmental Protection Agency, National Cancer Institute and U.S. Army. Symposium on "Toxic

chemicals and aquatic life: Research and management." Seattle, Washington, September 16-18, 1986. "Cytological changes during progression of neoplasia."

31. 1986 Charleston Area Medical Center, Charleston, WV Oncology Update '86. Panel

presentation and discussion "Water Pollution: Current West Virginia Studies." 32. 1987 Invited Speaker. Marine and Freshwater Biomedical Research Center. Oregon

State University. Cellular Organization of Teleost Liver: Relationship to Toxicity. Corvallis, Oregon, March 2-4, 1987.

33. 1987 American Fisheries Society, National Meeting, Winston Salem, North Carolina.

Invited Seminar Speaker in Special Seminar on "Effects of Environmental Stress on Fish Populations." Presentation title "Quantitative histopathology as a measure of environmental stressors in fish." September 18, 1987.

34. 1987 NIEHS, Extramural Reviewer, Marine and Freshwater Biomedical Research

Center. October 21-23. Oregon State University, Corvallis.

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35. 1988 Oregon State University Environmental Health Sciences Center Review Meeting, Salishan Lodge, Gleneden Beach, Oregon, March 27-29, 1988.

36. 1988 International Meeting of the Fish Health Section of the U.S. and Canadian Fisheries Society. Vancouver, British Columbia, July 20-24, 1988. Invited Speaker and Co-chair of Session on "Neoplastic and Proliferative Disorders of Fishes." Presentation entitled "Histo-and cytochemical differentiation of liver in Japanese medaka (Oryzias latipes}."

37. 1988 Environmental Conservation Division, Northwest and Alaska Fisheries Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, U.S. Department of Commerce, Seattle, Washington. Invited Seminar. July 25, 1988. "The intrahepatic biliary system of fish and its relationship to toxicity." 38. 1988 International Symposium on Fish Marking Techniques, Seattle, Washington, June 27-July 1. Bordner, C.E., Doroshov, S., Hinton, D.E., Pipkin, R., Fridley, R. and Haw, F. "An Evaluation of Marking Techniques for Juvenile Sturgeon in Captivity." 39. 1988 Special Endocrine Research Group Seminar. Department of Zoology, University of California, Berkeley, California. September 20, 1988. "Liver structure and its alteration by toxicity in selected fish species." 40. 1988 International Meeting of Pathologists in Aquaculture. October 2-6, 1988.

Virginia Institute of Marine Science, Gloucester, Virginia. Co-chair of session on Pathobiology and Toxicology. Delivered concluding remarks for the session.

41. 1988 Special Invited Member of Graduate Student Ph.D. Preliminary Examination Committee, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, October 7, 1988. 42. 1988 Lawrence Livermore Laboratory, Environmental Toxicology and Carcinogenesis Group. Invited Seminar Speaker. November 12, 1988. "Advantages of using Small fish in cancer research." 43. 1989 Invited Participant. Fish Carcinogenesis and Molecular Genetics Workshop, Mt.Hood, Oregon, August 1989. "Hepatocarcinogenesis in a small fish species." 44. 1989 Visiting Lecturer Series, Duke University Integrated Toxicology Program,

November 8-10, 1989. "Enzyme altered foci and their progression in liver of medaka {Oryzias latipes) exposed to diethylnitrosamine."

45. 1990 California Fish & Game Striped Bass Workshop, Donald Stevens, Coordinator. 46. 1990 Special Invited Speaker at Environmental Monitoring Systems Laboratory,

United States Environmental Protection Agency, Office of Research and

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Development, Cincinnati, Ohio. February, 1990. "Hepatocarcinogenesis in small fish species: a model ready for application."

47. 1990 Special Invited Speaker, United States Environmental Protection Agency, Sabine Island, Gulf Breeze, Florida. Symposium on pollutants in the marine environment and diseases in fish and shellfish. October 29 - November 1, 1990. "Toxicologic pathology of fishes." 48. 1990-91 Extramural Invited Member of PhD Dissertation Committee. Woods Hole Oceanographic Institution and Massachusetts Institute of Technology. 49. 1991 Invited Seminar Speaker, United States Environmental Protection Agency,

Office of Research and Development, Environmental Processes and Effects Research Seminar Series, Washington, D.C., March 12, 1991. "Marine animal diseases - relationship to pollution?.”

50. 1992 Annual Meeting of the Contractees of the U.S. Army Biomedical Research and

Development Laboratory, Fort Detrick, Frederick, Maryland, April 21-22, 1992. "Dietary Refinements in a Sensitive Fish Liver Tumor Model: Comparison of hepatic Neoplasm Frequency in Medaka Fed a Purified Casein Based or Conventional Diet."

51. 1992 Chesapeake Biological Laboratory, Solomons, Maryland. Present seminar, October 1-4,1992.

52. 1992 Oregon State University, Corvallis, Oregon. Site visit for the Environmental Health Sciences Program Project Application (2 P01 ESO 4766-06). October 13- 15, 1992.

53. 1992 Society of Environmental Toxicology and Chemistry, 12th Annual Meeting, November 9-12, 1992, Cincinnati, Ohio. Presentation entitled "Genetic Cellular and Histological Biomarkers of Diethylnitrosamine (DEN)-Induced Hepatotoxicity in medaka {Oryzias latipes)"

54. 1993 Invited Seminar Speaker, Tulane University, School of Public Health, New

Orleans, Louisiana, March 13, 1993. "The Medaka Hepatocarcinogenesis Model: A 20-Year Perspective."

55. 1993 Invited Speaker at the Pollution and the Environment Meeting of the Royal Microscopic Society, Oxford, England, April 14-16, 1993. Presentation entitled

"The Medaka {Oryzias latipes) Hepatocarcinogenesis Model: a Laboratory Surrogate for Aquatic Environmental Carcinogenesis Studies."

56. 1993 Seventh International Symposium on Responses of Marine Organisms to Pollutants (PRIMO 7), Goteborg, Sweden, April 20-22, 1993. Presentation entitled "Normal, Regenerational, and Diethylnitrosamine-Promoted Hepatic Growth in the Medaka {Oryzias latipes)."

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57. 1993 Member, Site Visit Team, Public Health Service, National Institutes of Environmental Health Sciences, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, May 5-7, 1993

58. 1993 Reviewer at the second Technical Advisory Committee (TAC) meeting of

the Toxics Theme Area ofNOAA's Coastal Ocean Program, Seattle, August 26-27, 1993.

59. 1993 Invited Participant, Joint Conference of the European Association for

Cancer Research (EACR) and Abteilung Experimentelle Krebsforschung der Deutschen Krebsgesellschaft (AEK) on hepatocarcinogenesis in Heidelberg, Germany, September 12-15, 1993.

60. 1993 Invited Participant in the Napa Conference on Genetic and Molecular

Ecotoxicology, Yountville, CA, October 12-15, 1993. 61. 1993 University of California Ecotoxicology Conference in Sacramento,,

October 14-15, 1993. Presentation entitled "Effects of Multiple Stresses on Ecosystems."

62. 1993 Invited Lecturer at Fifth Annual Research Review. U.S. Army Biomedical

Research and Development Laboratory, Frederick, Maryland. October 26- 27, 1993. "Dietary Refinements in a Sensitive Fish Liver Carcinogenesis Model."

63. 1993 Society of Environmental Toxicology and Chemistry 14th Annual

Meeting, 14-18 November 1993, Houston, Texas. Invited Presentation entitled "Avian and Aquatic Animals as Sentinels of Presence and Bioavailability of Pesticides."

64. 1993 Invited Lecturer at National Institute of Environmental Sciences, Marine

and Freshwater Biomedical Sciences Center, Rosenstiel School of Marine and Atmospheric Science, University of Miami, December 4-5, 1993. "Hepatic Biomarkers of Aquatic Toxicity: Defining the Cell-Specific Alterations within a Sensitive Teleost Organ."

65. 1993 Invited Lecturer and Participant in Pathology Working Group. National

Institute of Environmental Health Sciences. National Toxicologic Program. Research Triangle Park, North Carolina, December 15-16, 1993. December 15. Lecture Title: "Morphological Considerations for Selected Liver Lesions ofTeleosts." December 16. One of 16 Reviewers of Pathology Data from Dose Response Relationships for Hepatocarcinogenesis in Medaka Exposed to Waterbome N-Nitrosodiethylamine.

66. 1994 U.S. Department of Justice and State of California Attorney General's

Office. Presentation of Histopathology of Kelp Bass from Reference and Contaminated Sites off Southern California. January 25-26, 1994.

67. 1994 Invited Lecturer, Senior Class in Microscopic Anatomy, Department of

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Biology, The Citadel, The Military College of South Carolina, Charleston, South Carolina, February 24, 1994. "Histologic Criteria in Experimental Carcinogenesis Research in Liver."

68. 1994 Invited Lecturer, South Carolina Sea Grant Consortium, Fort Johnson

Marine Science Seminar Series - University of Charleston Marine-Freshwater Biomedical Research Center, February, 1994. “Cellular Alterations in Chronic Toxicity of Teleost Hepatocarcinogenesis: Cellular Selection, Clonal Expansion and their Importance.”

69. 1994 Conducted tour of laboratory and UC Davis for scientists working with fish

carcinogenesis and attending American Association for Cancer Research, San Francisco, CA, April 10-13, 1994.

70. 1994 Plenary Speaker at the International Symposium on Aquatic Animal Health in

Seattle, WA, September 4-8, 1994. "Biomarkers as indicators of toxic exposures."

71. 1994 Invited Speaker at the Sixth Annual Research Review. U.S. Army Biomedical

Research and Development Laboratory. "Dietary Refinements in a Sensitive Fish Liver Tumor Model." Frederick, MD, September 20-21, 1994.

72. 1994 Invited Lecturer. Department of Biology, Sonoma State University, Rohnert

Park, CA. "Histologic Approaches to the Investigation of Tumors in Fishes." November 22, 1994.

73. 1994 Invited Speaker at the Northern California Chapter of the Society of Toxicology,

Walnut Creek, CA. "Environmental Estrogens." November 14, 1994. 74. 1994 Seminar Speaker. West Virginia University, Department of Biochemistry, School

of Medicine, Morgantown, WV. "Correlated Biochemical and Structural Studies on Gender and Sensitivity to Liver Carcinogenesis: Using a fish in vivo model." December 8-9, 1994.

75. 1995 Society of Toxicology Meeting. Baltimore, MD, March 6-8, 1995. 76. 1995 Invited Speaker, Department of Pathology, University of Maryland, School of

Medicine, Baltimore, MD. "Biomarkers of Exposure and Adverse Effect in Ecotoxicology." March 6, 1995.

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77. 1995 State of California, Interagency Bay-Delta Ecological Task Force Meeting, Asilomar, CA. March 9-10, 1995. 78. 1995 Invited Workshop Discussant, "Critical Issues in Assessing Ecological Risk." University Extension, University of California; and Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Co- Sponsors. Asilomar Conference Center, Pacific Grove, CA. January 23-25, 1995. 79. 1995 Member, Steering Committee, Critical Issues in Assessing Ecological Risk. Environmental Hazard Management Program. University Extension, University Of California; and Office of Environmental Health Hazard Assessment, California Environmental Protection Agency - Co-sponsors.

80. 1995 Guidelines for Ecological Risk Assessment. Invited Speaker. "Biomarkers of Exposure and Adverse Effect in Ecological Risk Assessment. University Extension, University of California; and Office of Environmental Health Hazard Assessment, California Environmental Protection Agency - Co-sponsors. March 29-31, 1995. 81. 1995 National Institute of Environmental Health Sciences Ad Hoc Review Committee. Research Triangle Park, NC. March 16-17, 1995.

82. 1995 Host and Organizing Committee Chair. Eighth International Conference on "Pollutant Responses in Marine Organisms" (PRIMO 8). Asilomar Conference Center, Pacific Grove, CA. April 3-5, 1995. 83. 1995 Invited Participant. United States Environmental Protection Agency Workshop on "Endocrine Disrupters in the Environment." Raleigh, NC. April 10-13, 1995.

84. 1995 Invited Speaker. Fourth International Conference on Ecosystem Health Research. "Histopathological Indicators of Multiple Stressor Effects in Fish." Coimbra, Portugal. May 12-18, 1995.

85. 1995 Reviewer, Research Applications to Division of Agriculture and Natural Resources. U.C. Systemwide Committee. Review of 15 Applications. Oakland, CA. June 13, 1995.

86. 1995 Provided technical review on Directions and Administrative Materials for the County Sanitation Districts of Orange County, California - "Long Term Monitoring Program - Strategies and Methods for Analysis and Display of Data." Fountain Valley, CA. August 22-23, 1995.

87. 1995 Invited Speaker. West Coast Teratology Society, California Regional Primate Research Center, Davis, California, "Session II: Animal Models for Early Embryonic/Reproductive Damage: Fish" August 24-25, 1995.

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88. 1995 Participant. Central Valley Regional Water Quality Control Board, Sacramento, CA. "Investigate feasibility of an agricultural drain water wetlands "flow-through" system to biologically reduce selenium concentration." September 26, 1995.

89. 1996 Invited Participant. Sacramento River Toxic Pollutant Control Program Waste Management Board. Sacramento, February 21, 1996. 90. 1996 Participant. California Department of Pesticide Regulation. Hearing on acute toxicity of organophosphates to aquatic organisms. Sacramento, February 26, 1996. 91. 1996 Invited Speaker. Organization for Economic Co-operation and Development sponsored meeting on: Ecotoxicology: Responses, Biomarkers and Risk Assessment. "Histologic responses signifying exposure or effect and their application to aquatic ecotoxicology." Maui, Hawaii, April 1-13, 1996. 92. 1996 Invited Reviewer for Institute of Toxicology, Zurich, Switzerland. Review sponsored by University of Zurich and the Eidgenossische Technische Hochschule Zurich. April 27 – May 2,1996. 93. 1996 Invited Lecturer. Plymouth Marine Laboratory, Plymouth, England. "Ecotoxicologic investigations on the Sacramento River, its Delta and the upper San Francisco Bay. September 3, 1996. 94. 1997 Invited Expert Reviewer. United States Environmental Protection Agency.

Health Effects Research Laboratory, Duluth, MN. Conducted programmatic review as member of five person panel. March 25-27, 1997.

95. 1997 Invited Speaker at Duke University School of the Environment, Durham, NC. "Ecotoxicologic investigation on an imperiled watershed in Northern, California." April 17-19,1997. 96. 1997 Invited Faculty Lecturer. Short course in Aquatic Toxicology, University of Bergen, Bergen, Norway. "Teleost liver in health and toxicity." April 25, 1997. 97. 1997 Invited Platform Speaker. 9th International Meeting "Pollutant Responses

in Marine Organisms." University of Bergen, Bergen, Norway. April 27 - April 30, 1997.

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98. 1997 Invited Lecturer. National Institute of Public Health and the Environment, Bilthoven, The Netherlands. "Ecotoxicologic investigation on an imperiled watershed in Northern, California." May 1, 1997.

99. 1997 Invited Faculty. Institute de Biologia Molecular e Celular, Porto, Portugal. Short course in Molecular Ecotoxicology. "Molecular Pathology in Fishes." Porto, Portugal. May 5-9, 1997. 100. 1997 Invited Speaker. Sacramento Watershed Shareholders Meeting. Research at University of California - Davis in support of Sacramento River Watershed. Red Bluff, California. June 20, 1997. 101. 1997 Invited Participant. Workgroup on Toxicologic Mechanisms. Society of

Environmental Toxicology and Chemistry Pellston Conference. Workshop on developmental and reproductive toxicity in oviparous and viviparous vertebrates. Butte, Montana, July 12-17, 1997.

102. 1997 Invited Speaker. Bodega Marine Laboratory. Seminar Series. "Gender- specific growth and sensitivity to neoplasia in a fish species." Bodega Bay, CA. July 24-25, 1997. 103. 1998 Invited Speaker. University of Nagoya, Japan. Detection of Endocrine disrupting properties of xenobiotics. Nagoya, Japan. December 12-15. 104. 1999 Invited Speaker. Ninth Bi Annual Meeting. Pollutant Responses in Marine Organisms. College of William and Mary, Williamsburg, Virginia. May 30 – June 3, 1999. 105. 2001 Invited Speaker and Session Chairman. International Meeting on Endocrine Disrupting Compounds. Nagoya Japan. January 29-31. 106. 2001 Invited Speaker. 10th Biannual Meeting. Pollutant Responses in Marine Organisms. Plymouth England. 107. 2001 Invited Speaker. Session on livers of lower vertebrates. International Congress on Morphology, Jena, Germany. June 15-19. 108. 2001. Invited Speaker. University of Dresden. Dresden, Germany. “ “Carcinogenesis in small fish species: what accelerated investigations are possible using these sensitive vertebrates? “ June 16, 2001. 109. 2002 Visiting Professor. Department of Agriculture University of Nagoya. Laboratory of Fresh Water Fish Stocks. January 1- March 31, 2002. 110. 2002 Invited speaker. International Meeting on Medaka as a research Resource. Minimata, Japan. March 10-12, 2002.

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111. 2002 Invited Participant. U.S. E.P.A. Workshop on Use of Small Fish Species in risk assessment. August 14-17. 112. 2003 Student in “Quantitative flourescence microscopy”. June 1-6, 2003. Mount Desert Island Laboratory, Maine. 113. 2003 Invited Speaker. Cells of the Hepatic Sinusoids. Tucson, AZ August, 2003. EDITORIAL BOARDS Anatomical Record- Associate Editor, 1979-1995 Aquatic Toxicology, 1989-Present. Editor-in-Chief, 1996-2001 Comparative Hepatology- Deputy Editor, 2002- present Diseases of Aquatic Organisms-

Subject Editor,Relationship to Veterinary Research, 1987-1993; Subject Editor, Toxicant-Induced Pathology, 1993-1995 CRC Critical Reviews in Aquatic Toxicology- Member, Editorial Advisory Board, 1986-1990 Associate Editor, Toxicologic Pathology, March 1988-1995 Reviews in Aquatic Sciences-Associate Editor, 1988-1990 Bulletin of Environmental Contamination and Toxicology, Member, Editorial Board, 1991 Invited Reviewer, U.S. Army Corps of Engineers, “Effects of Dredge Material on Marine

Organisms,” 1984 REVIEW OF MANUSCRIPTS American Journal of Anatomy American Journal of Epidemiology Aquatic Toxicology Biochemical Pharmacology Canadian Journal of Zoology Canadian Journal of Fisheries and Aquatic Sciences Carcinogenesis Cancer Research Cell and Tissue Research Diseases of Aquatic Organisms Journal of Fish Physiology and Biochemistry Pesticide Biochemistry and Physiology Proceedings National Academy of Science REVIEW OF GRANT APPLICATIONS

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National Science Foundation (1979, 1980, 1983, 1984, 1985, 1986). Member, Special Review Committee. Contract Applications on Chemical Carcinogenesis Studies in Drinking Water. National Cancer Institute, Bethesda, Maryland, March, 15, 1982. NIEHS Ad Hoc Reviewer, 2002-2003 Chairman, Special Review Committee. Contract Application on Tumor Registry in lower Animals. National Cancer Institute, Bethesda, Maryland, March 15-16, 1982. March of Dimes Foundation, July, 1982. Consultant Member, Review Committee. National Institute Occupational Safety and Health, Cincinnati, Ohio, May, 1983. March of Dimes Foundation, September, 1984. U.S. Food and Drug Administration, July, 1988 U.S. Department of Agriculture, 1989, 1991 Norwegian Research Council, Regular Reviewer since 2001; Review Team Leader 2007 THESES AND DISSERTATIONS DIRECTED 1. 1972 M.K. Kendall, Ph.D. Acute effects of administration of methyl mercuric

chloride on tissues and enzyme activity in channel catfish (Ictalurus punctatus).University of Louisville, School of Medicine.

2. 1973 J.C.E. Koenig, Jr., M.S. Cell fractionation and characterization of hepatic acid phosphatase in fish exposed to methyl mercuric chloride. University

of Louisville, School of Medicine. 3. 1976 G.J. Kolaja, Ph.D. Effects of DDT on eggshell formation in the mallard duck. University of Maryland, School of Medicine. 4. 1979 M.M. Lipsky, Ph.D. Studies on the pathogenesis of safrole-induced hepatic neoplasia in the mouse. University of Maryland, School of Medicine. 5. 1980 J.E. Klaunig, Ph.D. Mouse liver cell culture. Isolation, primary culture, and application to carcinogenesis studies. University of Maryland, School of Medicine. 6. 1980 R.M. Jack, Ph.D. Studies on the hepatic microsomal mixed function oxidase system of channel catfish (Ictalurus punctatus, Rafinesque).

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Characterization, induction by xenobiotics, and benzo (a) pyrene metabolism, 1980. University of Maryland, School of Medicine. 7. 1983 E.M. Zuchelkowski, Ph.D. Effects of acid stress on epidermal mucous cells of the brown bullhead catfish (Ictalurus nebulosus, Lesueur). West Virginia University School of Medicine. 8. 1984 D.M. Kontir, Ph.D. Coal-associated pollutants and trout liver structure/function. West Virginia University School of Medicine. 9. 1985 J.A. Hampton, Ph.D. Histochemical and morphometric analysis of the tubular liver in rainbow trout (Salmo gairdneri). West Virginia University School of Medicine. 10. 1988 B.F. Droy, Ph.D. Effect of reference hepatotoxins on rainbow trout liver. West Virginia University School of Medicine. 11. 1988 T.L. Holliday, Ph.D. Comparison of carcinogenesis in resistant and sensitive teleost species. West Virginia University School of Medicine. 12. 1994 L.M. Parker, Ph.D. Biochemistry of normal and neoplastic change in two teleost laboratory models of hepatocarcinogenesis. West Virginia University School of Medicine. 13. 1995 M.J. Anderson, Ph.D. Modulation of estridiol-induced responses in fish by cytochrome P4501A1 inducing compounds: effects on liver sysnthesis of vitellogenin. Pharmacology and Toxicology. University of California – Davis. 14. 1996 Swee, J. Teh, Ph.D. Cellular aspects of hepatocarcinogenesis in medaka

(Oryzias latipes): dynamics of histogenesis and gender-related sensitivity. Comparative Pathology Graduate Group. University of California-Davis. 15. 1996 Mark S. Okihiro, DVM, Ph.D. Regenerative, hyperplastic, and neoplastic-

hepatic growth in medaka (Oryzias latipes) and rainbow trout (Oncorhynchus mykiss): an investigation of the role of the biopolar hepatic stem cell. Comparative Pathology Graduate Group. University of California-Davis.

16. 1996 Alex Villalobos, Ph.D. Developmental toxicity in embryos of the teleost medaka (Oryzias latipes) exposed to selected environmental contaminants. Pharmacology and Toxicology Graduate Group. University of California – Davis.

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17. 1996 Zi Liu, Ph.D. Sequences of ras proto-oncogenes in medaka (Oryzia latipes) and striped bass (Moron saxatilis) and in mutated ras alleles of diethylnitrosamine- induced hepatic neoplasms of medaka. Pharmacology and Toxicology Graduate Group. University of California – Davis.

18. 1996 Gary Marty, DVM, PhD. Microscopic structural analysis of fish development in aquaculture and aquatic toxicity testing. Comparative Pathology Graduate Group. University of California-Davis.

19. 1997 Jonathan Hamm, Ph.D. Developmental changes in the toxicity and bioactiviation of diazanon by embryos of medaka (Oryzias latipes). Pharmacology and Toxicology Graduate Group. University of California – Davis.

20. 1997 Janis Brencher Cooke, Ph.D. Effects of 17-beta-estradiol and

beta-hexachlorocyclohexane on liver and gonad morphology and on liver tumorigenesis induced by diethylnitrosamine in medaka (Oryzias latipes).

Pharmacology and Toxicology Graduate Group. University of California – Davis. 21. 2001 Debra Lynn Denton. Integrated Toxicological and Hydrological Assessments of Diazinon and Esfenvalerate. Hydrological Sciences. University of California-Davis. 22. 2002 Korey Scott Coger, Ph.D. Development and Use of A Teleost Model, Medaka (Oryzias latipes) for detection of xenobiotic induced reproductive toxicity. Pharmacology and Toxicology Graduate Group. University of California –Davis. 23. 2003 Corrine Davis, Ph.D. Gender and cultural factors affecting growth of medaka (Oryzias latipes) and their role as modulators of diethylnitrosamine-induced liver Carcinogenesis.Comparative Pathology Graduate Group. University of California-Davis. 24. 2004 Chris A. Pincetich, Ph.D. Metabolic changes in Japanese medaka (Oryzias latipes) during embryogenesis and hypoxia as determined by in vivo 31P NMR. Pharmacology and Toxicology Graduate Group. University of California-Davis. 25. 2005 David C. Volz, Ph.D. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Induces Organ- Specific Differential Gene Expression in Male Japanese Medaka (Oryzias latipes). Integrative Toxicology Program. Duke University.

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26. 2006 Regina Gail Linville, Ph.D. Effects of Excess Selenium on the Health and Reproduction of White Sturgeon (Acipenser transmontanus): Implications for San Francisco Bay-Delta. Ecology Graduate Group. University of California-Davis. 27. 2006 Ronald C. Hardman, Ph.D. In vivo in situ imaging of liver development and hepatobiliary toxicity in the see-through medaka (Oryzias latipes). Nicholas School of the Environment and Earth Sciences. Duke University. 28. 2009 Deanna L. Howarth, Ph.D. Characterization of FXR Alpha in Medaka and

its Involvement in Hepatobiliary Injury. Integrated Toxicology and Environmental Health Program, Duke University

POST DOCTORAL STUDENTS DIRECTED 1. 1979-82 R. Clark Lantz, Ph.D., West Virginia University 2. 1985-86 Arunthavarani Thiyagarajah, DVM, Sri Lanka, Ph.D., Auburn

University 3. 1987 Darrell Jon Laurén, Ph.D. McMaster University 4. 1996 Inge Werner, Ph.D., University of Mainz, Germany, and San Francisco State University, Tiburon, CA 5. 1996 Seth Kullman, Ph.D., University of California, Davis 6. 2000-2003 Shosaku Kashiwada, Ph.D. Nicholas School, 7. 2000-2002 Miguel Gonzalez-Doncel, Ph.D.Complutense University, Madrid, Spain. 8. 2002-2004 David C. Bencic, Ph.D., University of Idaho, Moscow ID. 9. 2005-2007 Bonny Bun Ho Yuen, Ph.D., City University of Hong Kong. 10. 2009-Present Wing Hin Kevin Patrick Kwok, University of Hong Kong. SABBATICAL FELLOWS SPONSORED 1. 1990 Thomas A. Braunbeck, Assistant Professor of Zoology, University of Heidelberg, Heidelberg, Germany 2. 1990-91 David F. Hanes, Professor, Department of Biology, Somona State

University, Somona, California 3. 2009 Julie Mondon, Lecturer, Deakin University, Warrnambool,

Australia