Embed Size (px)
Citation preview
Shen JG
CURRICULUM VITAE
Jiangang Shen
CONTACT INFORMATIONSchool of Chinese Medicine,University of Hong Kong,10 Sassoon Road, Hong Kong,Hong Kong SAR, ChinaPhone: +852-2589 0429 Fax: + 852-2168 4259 E-mail: [email protected];
CURRENT ACAEMIC POSITIONSAssociate Professor, Assitent Director,Coordinator for Research Affairs,School of Chinese Medicine, University of Hong Kong
CURRENT ADMMINISTRATION APPOINTMENTS
Administration Appointments Held in University of Hong Kong(1) Chair of Department of Research Postgraduate Students Committee, School of Chinese Medicine(2) Co-opted member of the Committee of Management of School of Chinese Medicine(3) Board member of Faculty of Medicine, University of Hong Kong(4) Board member of Studies of Chinese Medicine (5) Member of Examiner Board for the Bachelor of Chinese Medicine
Administration Appointments Held in Hong Kong Hospital Authority (1) Co-opted member in Clinic Management Committee of Tung Wah Group of Hospital-HKU
Clinic Center for Teaching and Research in Chinese Medicine (Eastern)(2) Co-opted member in Clinic Management Committee of Hong Kong Buddhist Hospital-HKU
Clinic Centre for Teaching and Research in Chinese Medicine(3) Member of Centre Committee of Chinese Medicine Strategic Development of Hospital
Authority
1
Shen JG
EDUCATION AND TRAINING:
Education1995.9-1998.7 Ph.D. in Molecular Biophysics, Institute of Biophysics Chinese Academy of Science,
China1987.9-1990.7 Master of Medical Science in Integrated Medicine. Sun Yat-sen University of
Medical Science, China1979.7-1984.7 M.B.B.S. in Chinese Medicine, Hunan Chinese Medical University, China
Postdoctoral training1998.9-1999.8 Postdoctoral Research fellow, Anesthesia Research Laboratories, Brigham and Women’s Hospital and Harvard Medical School, Boston, U.S.A.1984.7-1987.8 Resident training, Internal Medicine and Traditional Chinese Medicine,
Nan-Fang Hospital, The First Military Medical University, Guangzhou, China
PROFESSIONAL APPOINTMENTS:
Academic Appointments:2007.1- Associate Professor, Assistant Director, School of Chinese Medicine, University of
Hong Kong, China 2005.11-2007.1 Assistant Professor, School of Chinese Medicine, Chinese University of Hong
Kong, Hong Kong, China 2004.8-2005.12 Assistant Professor, Director, EPR Center, College of Pharmacy, Health Science
Center, University of New Mexico, USA2001.9- 2004.9 Research Assistant Professor, Department of Medicine, The University of Hong
Kong, Hong Kong, China 1999.8- 2001.9 Senior Research Scientist, National EPR center, Department of Radiology,
Dartmouth Medical School, Hanover, USA1995.7-1998.7 Associate Professor, Associate Director, Institute of Chinese Medicine, Nan-Fang
Hospital, The First Military Medical University, China1990.7-1995.7 Lecturer, Institute of Chinese Medicine, Nan-Fang Hospital, The First Military Medical University, China
Hospital Appointments:1995-1998 Associate Director, Associate Professor, Department of Chinese Medicine,
Nan-Fang Hospital and The First Military Medical University, China1990-1995 Attending Physician, Division of Cardiology, Institute of Chinese Medicine, Nan-Fang Hospital and The First Military Medical University, China
2
Shen JG
Professional Societies 2010- Member, World Stroke Organization 2005- Member, American Chemical Society2000- Member, Oxygen Society1999- Member, International Society on Oxygen Transport to Tissue1996- Member, American Association for the Advancement of Science1995- Member, International Society of Free radical Research1996- Member, The New York Academy of Sciences1989- Member, Chinese Biophysical Society
HONORS AND PROFESSIONAL ACTIVITIES
Honor Professorship:2008.10 Honorary Professor, Wenzhou Medical College, China2008.1 Honorary Professor, South China University of Technology, China2006.9 Honorary Professor, Hunan Chinese Medical University, China2006.1 Assistant Professor, College of Pharmacy, University of New Mexico, USA2005.7 Honor Professor, China West Hospital, Sichuan University, China
Honors and Awards2009 National Scientific Achievement Award , Chinese Medical Chapter, P.R.China 2008 Member, Local Organizing Committee, XIV Biennial Meeting of the Society for Free
Radical Research International 18-22 October, 2008 Beijing, China2008 Co-ordinator, Scientific Advisor Board Member, the 7th National Conference on Free
Radical Biology & Medicine, 17-18 October, Beijing, China 2007 Co-Chair, Neuroimaging Section, World Congress on Aging and Dementia in Chinese
Community . Hong Kong, 20072002 Young Investigator Award, the 7th Medical Research Conference, Hong Kong1998 Scientific Achievement Award (Second Class), National Military Medical Ministry, China1998 Dio Award, Chinese Academy of Science, China1997 Scientific Achievement Award (Third Class), National Military Medical Ministry, China1997 Young Scientist Traveling Award of the Fifth International Meeting of Nitric Oxide Biology,
September 15-19, 1997 in Kyoto, Japan.1997 Young Scientist Traveling Award of the First Asia – Pacific Symposium of EPR/ESR,
January 17-20, 1997 in Hong Kong
National and Local Scientific Panel and Grant Reviewer 2007- Chairman, Reviewer Panel, Pong Ding Yuen Endowment Fund for Research in Chinese-
3
Shen JG
western Medicine, Hong Kong2006- Invited Grant Reviewer, Chinese Medicine Panel, National Natural Science Foundation of
China1998 Member, Chinese Medicine Panel, Natural Science and Technology Foundation of
Guangdong Province, China
Clinical ServicesRegistered Senior TCM Practitioner in Internal MedicineSpecialist in Cardiovascular Diseases, Neurological Diseases, Depression and Mental Disorders
Teaching CoursesBCHM3002 Chinese Internal MedicineMCHM 6107 Application of Modern Statistics for Data Process in Chinese Medicine MCHM 6303 Chinese Internal Medicine Series IMCHM 6400 Chinese Internal Medicine Series IIMCHM6401 Chinese Internal Medicine for Clinical Teaching MBBS Selective Course: TCM Basic Principles and Methods Certificate Course for Hospital Authory: TCM Diagnostics
JOURNAL REFEREE ACTIVITIESAd Hoc reviewer: Archives of Biochemistry and Biophysics, Neuroscience Letter. Acta Pharmacologica Sinica, Journal of Neurochemistry, Neural Regeneration Research,Journal of Alzheimer's Disease, Brain Research, etc.Editorial Board: American Journal of Biomedical Sciences
CURRENT RESEARCH DIRECTIONS1. Drug discovery from herbal medicine for neural regeneration and recovery of neurological
functions in the treatments of post-stroke and neurodegenative diseases2. Development of nano-antioxidants isolated from herbal medicine for protection of neural cells
from oxidative injury in ischemic stroke3. Signal transduction, molecular and functional imaging for ischemic brain injury 4. Quality control and clinical evaluation on traditional Chinese herbal formula for the treatment of
ischemic stroke and others AWARDED SCIENTIFIC GRANTSPrincipal Investigator for External Competitive Grants:
4
Shen JG
2011.9-2014.8 Effects of reactive nitrogen species inhibitors on preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in cerebral ischemia-reperfusion injury. RGC GRF grant, Hong Kong, HK$ 890,000
2010.9-2013.8 Elucidating caveolin-1 as a negative modulating protein for proliferation anddifferentiation of neural stem/progenitor cells in post-ischemic brain. RGC GRF grant, No. 777610M, Hong Kong, HK$1,084,600
2009.1-2011.12 Interactions of reactive nitrogen species, caveolins and matrix metalloproteinases: A novel signal mechanism in disruption of blood brain barrier during ischemic stroke. RGC GRF grant No. 774408M, Hong Kong, HK$ 1,191,369
2005.1-2007.12 Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke. RGC Competitive Earmarked Research Grant No. 749504M, Hong Kong HK$ 939,968
2004.1-2006.12 Effects of “Huang Shan Yao” on regulating lipid metabolism and protecting ischemic myocardium. National Natural Science Foundation of China. RMB: 200,000
2004.1-2006.12 Effects of Buyang Huanwu Decoction on neuronal regeneration after ischemic brain injury and chemical analysis of ingredients. National Natural Science Foundation of China RMB: 190,000
1999.1-2002.12 Molecular pharmacological study of Buyan Huangwu Decoction, a classic TCM formula, against cerebral ischemia damage. Grant from National Natural Science Foundation of China. RMB: 140,000
1998.1-2000.12 Serum pharmacological study of Yiqi Tongluo Pill against cardiomyocyte apoptosis in hypoxia-reoxygenation injury. Grant from Natural Science Foundation in Guangdong Province, China. RMB: 100,000
1994.1-1996.12 Protective mechanisms of an Chinese medicine “Yiqi Tongluo Pill” on myocardial ischemia-reperfusion injury. Grant from National Natural Science Foundation of China. RMB 60,000
Principal Investigator for Internal Competitive Grants, Donations and Match Funds:
2011.4-2012.3 Effects of reactive nitrogen species inhibitors on preventing thrombolysis-induced blood brain barrier disruption and hemorrhagic transformation in cerebral ischemia-reperfusion injury. Seed Funding for Basic Research, The University of Hong Kong HKD: 98,590
2010.6-2011.5 Development of Hydroxysafflor Yellow A (HSYA) as a Botanical Drug for Reducing Blood Brain Barrier Permeability and Preventing Infarction Enlargement in Stroke Treatment. Seed Funding for Applied Research, The University of Hong Kong HK$ 100,000
2009.4-2010.3 Effects of Baicalin on promoting differentiation of neural stem cells into neurons in post-ischemic stroke rats. Seed Funding for Basic Research, The University of Hong Kong HKD: 70,000
5
Shen JG
2010.1.1-2010.12 Elucidating Effects and Mechanisms of Isoflavonoids from Astragalus Mongholicus in Improving Neurogenesis for Post-stroke Treatment. Small Grant for Basic Research, The University of Hong Kong HK$ 60,000
2008.11-2010.10 Development of caveolin-1 as a target molecule for screening active compounds from herbal medicine in promoting neurogenesis for ischemic stroke. Small Grant for Basic Research, The University of Hong Kong HK$ 60,000
2009.1-2011.7 Interactions of reactive nitrogen species, caveolins and matrix metalloproteinases: A novel signal mechanism in disruption of blood brain barrier during ischemic stroke. Merit Award for GRF project, HKU, HK$ 50,000
2008.1-2010.12 Research and development of Chinese Medicine for improving neural regeneration and recovery of neurological function in post-stroke treatment. Private Donation for Research, HK$ 500,000
2008.3-2010.3 Research and development of Chinese Medicine for improving neural regeneration and recovery of neurological function in post-stroke treatment. Government Match Fund for Donation on TCM stroke research, HK$ 125,000
2008.1-2009.12 Development of TCM for stroke treatment. GB Donation HK$ 150,0002008.1-2009.12 Development of nano-salvianic acids for protecting neural cells from oxidative
injury. Seed Funding Programme for Basic Research, The University of Hong Kong. HK$ 80,000
2007.1-2008.12 Seeking active components from Buyang Huanwu Decoction for improving proliferation and differentiation of neural progenitor cells in post-stroke treatment. Seed Funding for Applied Research, The University of Hong Kong HK$ 200,000
2006.1-2007.12 Effects of Buyang Hanwu Decoction on improving neuronal regeneration in hippocampus and recovery of neurological function after ischemic brain injury. Director Grant, Chinese University of Hong Kong HK$ 60,000
2004.1-2005.12 Effects of Buyang Huanwu Decoction, a classic formula of Traditional Chinese Medicine, on neuronal regeneration in experimental ischemic stroke. Seed Funding for Basic Research, The University of Hong Kong HKD: 90,000
2004.1-2005.12 Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke. Small Project Funding, The University of Hong Kong HK$ 120,000
2003.1-2004.12 Role of caveolins in free radical generation of hypoxia-reoxygenated neuronal cells: implication for neuronal oxidative damage of ischemia stroke. Seed Funding for Basic Research, The University of Hong Kong. HK$ 200,000
2002.1-2003.12 Effect of intracellular cholesterol trafficking on nitric oxide synthase, reactive oxygen species and cell death in Chinese hamster ovary cells under oxidative stress. Seed Funding for Basic Research, The University of Hong Kong HK$ 120,000
2002.1-2003.12 Relationship among cellular oxygen, abundance of cholesterol and cell death in Chinese hamster ovary cells and endothelial cells under oxidative damage. Research Grant of University Department of Medicine, The University of Hong Kong HK$ 75,000
6
Shen JG
1993.1-1994.12 Free radical mechanisms of ischemia heart diseases and protection of a Chinese medicine decoction. Grant from President Foundation of the First Military Medical University, China RMB 20,000
Co-PI or Co-I for External Competitive Grants :2009.1-2011.12 Multiple center clinical trials and experimental research on Si-Mo Decoction for
gastrointestinal motility disorders. National 973 Exploration Project (Co-I) RMB 6,000,000
2009.1-2011.12 Caveolin-1/Notch1 pathway is one of the signal mechanisms of Buyang Huanwu Decoction in promotion of neurogenesis after ischemic stroke (Co-I). National Natural Science Foundation of China. RMB: 400,000
2004.1-2006.12 Adiponectin as a novel diagnostic marker and therapeutic target for treatment of diabetes, steatohepatitis and other metabolic disorders. Innovation and Technology Fund of Hong Kong (Collaborator, PI for one branch) HKD: 3,000,000
1992.1-1995.12 Stress and aging hyperliidema. Grant from Military Medical Ministry of PLA, P. R. China (Co-investigator) RMB 100,000
PUBLICATIONS Selective Peer-refereed Academic Journals1. Zhao H*, Ren CC, Chen XM, Shen JG.. From rapid to delayed and remote postconditioning: the evolving
concept of ischemic postconditioning in brain ischemia. Current Drug Targets 2012; 13(2):1-142. Wang Z, Cheng Y, Wang N, Wang DM, Li YW, Han F, Shen JG, Yang DP, Guan XY, Chen JP.
Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins. Cancer Biology & Therapy 2012; 13(3), Feb 2012
3. Li Y, Zhuang PW, Shen BR, Zhang YJ, Shen JG*. Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression. Brain Research 1429:36-42; 2012
4. Gu Y, Zheng GQ, Xu MJ, Li Y, Chen XM, Zhu WZ, Tong Y, Chung SK, Liu KJ, Shen JG*. Caveolin-1 regulates nitric oxide mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. Journal of Neurochemistry 2011 Oct 18. doi: 10.1111/j.1471-4159.2011.07542.x. [Epub ahead of print] (Highlight of the Issue with Editorial Comments)
5. Lee W, Xu M, Li Y, Gu Y, Chen J, Wong D, Fung PC , Shen JG*. Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury . Arch Biochem Biophys. 2011, 514(1-2):57-67. (Cover Story)
6. Li Y, Luo JM, Zheng GQ, Fu SP, Wang TT, Zeng HP, So KF, Chung SK, Tong Y, Liu KJ, Shen JG*. Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. PLoS One 6(8):e22901, 2011
7. Xu WC, Shen JG*, Jiang JQ. Phytochemical and biological studies of the plants from the genus daphne. Chem Biodivers. 8(7):1215-1233; 2011
7
Shen JG
8. Li Y, Lau WM. So, KF, Tong Y, Shen JG*. Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression. Neurochemistry International 59(2):114-121, 2011
9. Li Y, Lau WM, So KF, Tong Y, Shen JG*. Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochemical and Biophysical Research Communications 407(3):517-524, 2011
10. Wang ZY, Loo TY, Shen JG, Wang N, Wang DM, Yang DP, Mo SL, Guan XY, Chen JP. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. Breast Cancer Res Treat. 2011 Mar 31. [Epub ahead of print]
11. Shen JG*, Lee WS, Chen JP, Yang DP. Caveolin-3 peptide protects cardiomyocytes from apoptotic cell death via preserving superoxide dismutase activity and inhibiting caspase-3 activation under hypoxia-reoxygenation. American Journal Biomedical Sciences 3(2), 126-144; 2011
12. Shen JG*, Gu Y, Tong Y, Fung PC, Tong L. Ginkgo biloba extract (EGb 761) prevents apoptosis in hypoxia-reoxygenated cardiomyocytes: involvement of mitochondria-dependent caspase pathway. Chinese Medicine 6: 8, 2011
13. Zheng GQ, Zhao ZM, Wang Y, Gu Y, Li Y, Chen XM, Fu SP, Shen JG*. Meta-analysis of scalp acupuncture for acute hypertensive intracerebral hemorrhage. Journal of Alternative and Complementary Medicine 17(4):293-299, 2011
14. Gu Y, Dee CM, Shen JG*. Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability in cerebral ischemia and reperfusion injury. Frontier in Bioscience 3:1216-1231, 2011
15. Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. Journal of Ethnopharmacology133(2):751-758, 2011
16. Xu XC, Yang Y, Du LB, Shen JG*, Wang GQ, He Z, Tian Q, Liu Y. Autoxidation and prooxidation mechanism of Danshensu. Acta Phys Chim Sin 26(7):1737-1741, 2010
17. Zheng GQ, Li Y, Gu Y, Chen XM, Zhou Y, Zhao SZ, Shen JG*. Beyond water channel: Aquaporin-4 in adult neurogenesis. Neurochemistry International. 56(5):651-654, 2010
18. Zhai JJ, Liu ZL, Li JM, Chen JP, Jiang L, Wang DM, Yuan J, Shen JG, Yang DP, Chen JQ. Different mechanisms of cis-9,trans-11- and trans-10,cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. Journal of Nutritional Biochemistry. 21(11):1099-105; 2010
19. Shen JG, Sood R, Weaver J, Timmins GS, Schnell A, Miyake M, Kao JP, Rosen GM, Liu KJ. Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: Application to focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism29(10):1695-1703, 2009
20. Tu TZ, Shen JG, Jiang JQ. Studies on constituents from the roots of astrgalus membranaceus (Fisch.) Bge. Hisao. West China Journal of Pharmaceutical Sciences 24(5): 27-29, 2009.
21. Mao WW, Wang TT, Zeng HP, Wang ZY, Chen JP, Shen JG*. The design, synthesis, and evaluation of novel substituted 5-hydroxycoumarin and pyranocoumarin derivatives exhibiting high antiproliferative activity. Bioorganic & Medicinal Chemistry Letters19(16): 4570-4573, 2009
8
Shen JG
22. Ye XS, Feng YB, Tong Y, Ng KM, Tsao SW, Liu GK, Sze CW, Zhang YB, Tang J, Shen JG, Kobayashi S. Hepatoprotective and anti-oxidative effects of Coptidis Rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. Journal of Ethnopharmacology 124(1):130-136, 2009
23. Liu WL, Hendren J, Yuan ZR, Shen JG, Liu KJ. Normobaric hyperoxia attenuates early blood brain barrier disruption by inhibiting MMP-9-mediated occluding in focal cerebral ischemia. Journal of Neurochemistry 108:811-820, 2009
24. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH, Shen JG*. Characterization of the chemical components in the Extracts from Si-wu decoction induce proliferation of rat mesenchymal stem cells (rMSCs). Bioorganic & Medicinal Chemistry 16(9):5109-5114, 2008
25. Shen JG*, Lee WS, Li Y, Lau CF, Ng KM, Fung ML, Liu KJ. Interaction of caveolin-1, nitric oxide, and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells. Journal of Neurochemistry 107:478-487, 2008
26. Rong JH, Cheung CY, Lau AS, Shen JG, Tam PH, Cheng YC. Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress. International Journal of Molecular Medicine 21: 405-411, 2008
27. Shi J, Tong Y, Shen JG, Li HX. Effectiveness and safety of herbal medicines in the treatment of irritable bowel syndrome: A systematic review. World Journal of Gastroenterology14(3):454-462, 2008
28. Liu BY, Shen JG. Effects of Buyang Huanwu Decoction on caveolin-1 and -2 expression in cerebral ischemic rats. Journal of Hunan Chinese Medical University 28(1):22-28, 2008
29. Tong L., Tan X.H., Shen JG., Comparative study of Buyang Huanwu Decoction and the different combinations of its ingredients on neurogenesis following ischemic stroke in rats, Chinese Journal of Intergrated Medicine. 27(6): 519-22, 2007
30. Ren JY, Fung PC, Chang CQ, Shen GX, Chan FH, Shen JG*. A comparison study on blood and tissue nitric oxide concentration during renal ischemia-reperfusion injury with electron paramagnetic resonance spectroscopy. Applied Magnetic Resonance 32:243-255, 2007
31. Rong JH, Titon R, Shen JG, Ng KM, Liu C, Tam PK, Lau AS, Cheng YC. Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the eselection of multiple marker genes as a potential metric for quality control. Journal of Ethnopharmacology 113(1):35-44, 2007
32. Cai GX, Liu BY, Liu W, Tan XH, Rong JH, Chen XM, Tong L, Shen JG*. Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. Journal of Ethnopharmacology 113 (2): 292-299, 2007
33. Miyake M, Shen JG, Liu SM, Shi HL, Liu WL, Yuan ZR, Pritchard A, Kao JPY, Liu KJ, Rosen GM. Acetoxymethoxycarbonyl nitroxides as EPR pro-imaging agents to measure O2 levels in mouse brain: A pharmacokinetic and pharmacodynamic study. Journal of Pharmacology and Experimental Therapeutics 318, 1187-1193, 2006.
34. Yang D, Wang H., Sun Z, Chung NW, Shen JG, A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells , Journal of the American Chemical Society. 128: 6004-6005, 2006.
9
Shen JG
35. Shen JG, Liu SM, Miyake M, Liu WL, Pritchard A, Kao JP, Rosen GM, Timmins GS, Tong Y, Liu KJ. Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe for measurement of tissue oxygenation in mouse brain. Magnetic Resonance in Medicine 55, 1433-1440, 2006
36. Shen JG*, Ma S, Chan CP, Fung PC, Cheung RTF, Liu KJ. Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion. Journal of Neurochemistry 96; 1078-1089, 2006
37. Chen BY, Lam KS, Wang Y, Wu DH, Lam MC, Shen JG, Wong LC, Hoo RL, Zhang JL, Xu AM. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications 341: 549-556, 2006
38. Tan XH, Qu HD, Peng K, Chen YY, Tong L, Shen JG, Zhu CW. Effects of Buyang Huanwu decoction on nerve proliferation in rats with sequelae of ischemic stroke. Journal of Southern Medical University. 26(2):189-92, 2006
39. Chang CQ, Ren JY, Fung PCW, Hung YS, Shen JG, Chan FHY. Novel sparse component analysis approach to free radical EPR spectra decomposition. Journal of Magnetic Resonance 175: 242-255, 2005
40. Ren JY, Chang CQ, Fung PCW, Shen JG, Chan FHY. Free Radical EPR Spectroscopy Analysis using blind source separation. Journal of Magnetic Resonance 166(1):82-91,2004 (Citation 7)
41. Qu HD, Tong L, Shen JG. Effect of buyang huanwu decoction drug serum on expression of p53 and p21 genes in cultured rat's cerebral cortical neuron after hypoxia in vitro. Chinese Journal of Integrated Medicine 24(2):133-5. 2004
42. Shen JG, Khan N, Lewis LD, Ray A, Swartz H. Cellular respiration rates and oxygen concentration in lymphoblastic Molt-4 cells and there ρ0 derivative. Biophysical Journal 84(2): 1291-1298, 2003
43. Khan N, Shen JG, Chang TY, Fung PCW, Grinberg O, Swartz H. Plasma membrane cholesterol: a possible barrier to intracellular oxygen gradients in CHO cells. Biochemistry 42(1): 23-29,2003
44. Liao CL, Tong L, Shen JG. Experimental studies of Buyang Huanwu decoction (BYHWD) against cerebral ischemia injury. Chinese Remedies & Clinics 3(3): 176-178, 2003
45. Liao CL, Tong L, Shen JG. Effects of Buyang Huanwu decoction (BYHWD) on nitric oxide synthase activities in mouse MCAO ischemic brain. Pharmacology and Chinese Material Medicine 19(4)﹕ 5-7 2003
46. Shen JG, Qiu XS, Jiang B, Zhang DL, Xin WJ, Fung PC, Zhao BL. Nitric oxide and oxygen radicals induced apoptosis via bcl-2 and p53 pathway in hypoxia-reoxygenated cardiomyocytes. Science in China (Series C) 46(1): 28-39, 2002
47. Shen JG, Bottle S, Khan N, Micallef A, Swartz HM. Development of isoindoline nitroxides for EPR oxymetry in viable biological systems. Applied Magnetic Resonance 22:357-368, 2002
48. Tong L, Shen JG, Qiu XS. Preventive effect of Buyang Huanwu Decoction on cardiomyocyte apoptosis induced by hypoxia-reoxygenation in rats. Chinese Journal of Integrated Medicine 22(7):522-4, 2002
10
Shen JG
49. Qu HD, Tong L, Shen JG, Chen YY. Protective effect of Buyang Huanwu decoction on cultured rat cortical neurons against hypoxia-induced apoptosis. Journal of the First Medical University of PLA 22(1):35-8, 2002
50. Tong L, Qu HD, Chen YY, Shen JG. Effects of Buyang Huanwu decoction (BYHWT) on proliferation of cultured rat cortical neurons. Journal of the First Medical University of PLA 22(8):711-2. 2002
51. Chen SY, Qu HD, Lu L, Shen JG. Nitric oxide induced apoptotic cell death in hypoxic neurons via regulating bcl-2 pathway. Journal of Changcun Chinese Medical College 16(7): 28-31, 2001
52. Xu AG, Li SG, Liu JH, Shen JG, Gan AH. Huangsheng formula induces apoptotic cell death in gastric carcinomatic cells via nitric oxide mechanism. Chinese Journal of Practical Internal Medicine 21(4): 225-226, 2001
53. Shen JG, Tong L, Qiu XS, Qu HD, Chen YY. “Yiqi Tongluo” pellet inhibits cardiomyocyte apoptosis induced by reoxygenation following hypoxia. Journal of the First Medical University of PLA 21(10):743-745, 2001
54. Qiu XS, Chen SY, Shen JG. Experimental study on YQTLD's effect on bcl-2 expression of cardiac myocyte under hypoxia-reoxygenation. Chinese Journal of Basic Medicine In Traditional Chinese Medicine 7(3):38-40, 2001
55. Shen JG, Li M, Xin WJ, Zhao BL. Effects of chinonin on nitric oxide free radical, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Applied Magnetic Resonance 19: 9-19,2000.
56. Shen JG, Quo X, Li M, Xin WJ, Zhao BL. Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation. Biochimica et Biophysica Acta 1500: 217-226, 2000 (Citation 38)
57. Xu AG, Li SG, Liu JH, Shen JG, Jiang B, Gang AH. Correlation between apoptosis and proliferation in gastric pre-carcinomatic patients. Chinese Medical Journal 79(3):185-186, 1999.
58. Xu AG, Li SG, Liu JH, Shen JG, Gang AH. Clinical study on Huang-Sheng Capsule in treatment of stomach carcinoma patients: Involvement of nitric oxide-induced apoptosis. World Chinese Journal of Digestive Diseases 7(4):364-365, 1999
59. Xu AG, Li SG, Liu JH, Shen JG. Comparative study of 5-FU and Huangsheng formula inducing apoptotic cell death in gastric carcinomatic cells. Chinese Journal of Digestive Diseases 19(3): 202-204, 1999
60. Shen JG, Wang J, Zhao BL, Hou JW, Gao TL, Xin WJ. Effects of EGb 761 on generation of nitric oxide, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Biochimica et Biophysica Acta 1406:228-236,1998
61. Zhao B, Shen JG, Tang C, Hou J, Xin W. Analysis of ESR spectroscopy of nitric oxide free radicals trapped by DETC iron complex in biological tissue. Chinese Journal of Magnetic Resonance 4:138-142, 1998
62. Guo Z, Shen JG, Chen Y, Jia M, Liu Y, and Chen S. Effects of Ginkgo biloba extract on oxygen free radicals, nitric oxide and fibrinolytic activity in patients with coronary artery diseases. South China Journal of Cardiology 4(4):234-238,1998
11
Shen JG
63. Shen JG, Guo Z, Tong L, Chen Y, Jia M, Liu Y. Mechanisms of Yiqi Tongluo pill in oxygen free radicals, nitric oxide and fibrinolysis in coronary heart diseases and hypertension patients. Chinese Journal of Integrated Medicine 17(7):410-3,1997
64. Zhao B, Shen JG, Hou J, Xin W. Studies on NO free radical generated from ischemia-reperfusion tissue and polymorphonuclear leukocyte (PMN). Chinese Journal of Magnetic Resonance 14(2):99-106, 1997
65. Zhao B, Shen JG, Li M, Li MF, Wan Q, Xin WJ. Scavenging effects of Chinonin on NO and oxygen free radicals and its protective effects on the myocardium from the injury of ischemia-reperfusion. Biochimica et Biophysica Acta 1315: 131-137,1996 (Citation 20)
66. Zhao BL, Shen JG, Hu J, Wan Q, Xin W. Synergic effects of NO and oxygen free radicals in the injury of ischemia-reperfused myocardium---ESR studies on NO free radicals generated from ischemia-reperfused myocardium. Science in China (Series C) 26, 491-500, 1996
67. Shen JG, Zhao BL, Hu JG, Wan Q, Xin W. Effect of “Yi Qi Tong Luo Ye” on oxygen free radicals, nitric oxide and myocardial damage after ischemia-reperfusion. Medical Biophysics 8, 7-11, 1996
68. Guo Z, Shen JG, Tong L, Chen Y, Jia M, Liu Y. The relationship of serum MDA, nitric oxide, tissue-type plasmogen fibrinolytic activator in ischemia heart diseases and hypertension patients. Chinese Journal of Circulation. 11(7):435-437, 1996
69. Shen JG, Guo Z, Tong L, Chen Y, Jia M, Liu Y. Effects of “Yiqi Tingluo Pill” on plasma free radicals, nitric oxide and fibrinolytic activates in ischemia heart diseases and hypertension patients (I). Pharmacology and Chinese Material Medicine 12(3): 42-44, 1996
70. Tong L, Chen Y, Shen JG. Myocardial ischemia-reperfusion injury in aging rats and the protective effects of “Yiqi tongliu dan”. Chinese Journal of Experimental Traditional Medicine Formula. 2(4):46-47, 1996
71. Shen JG, Guo Z, Chen S. Influence of “Yiqi tongluo dan” on lipid peroxide and fibrinolytic activities during myocardial ischemia-reperfusion injury. Chinese Journal of Pathophysiology. 12(2): 139-143, 1996
72. Guo ZG, Shen JG, Liu YL, Zhang RH. Effects of low dose lovastatin on hypercholesterolemia patients. Journal of the First Medical University of PLA 15(4):299, 1995
73. Jia YH, Chen SY, Lu ZP, Xu WX, Cui ZY, Shen JG. Relationship between tongue colour and cardiovascular functions: A clinic study on 116 cases of cardiovascular diseases. Chinese Journal of Integrated Medicine 15(6): 331-333, 1995
74. Shen JG, Zhou D. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochemistry and Molecular Biology International 35(1): 125-134, 1995 (Citation 71)
75. Shen JG, Hou C, Chen Y and Liu Z. Hyperbaric oxygen induced lipid peroxidation injury. Basic Medicine and Clinic 12(3):59-60, 1992
76. Shen JG, Chen Y, Liu Z, Hou C. Effects of ebselen against hyperbaric oxygen-induced lipid peroxidation injury. Bulletin of Chinese Pharmacology 8(2): 160-161, 1992
77. Shen JG, Chen Y, Zhou M, Hou C, Liu Z. Experimental studies of extraneous superoxide dismutase against free radical injury under hyperbaric oxygen. National Medicine Journal of China 71(11):642-644, 1991
12
Shen JG
78. Shen JG, Chen Y, Zhou M, Hou C, Liu Z. Effects of “ Gaoyan lin” and “Yiqi tonglu dan” against lipid peroxidation injury under hyperbaric oxygen. Chinese Journal of Integrated Medicine Suppl: 337-340, 1991
79. Shen JG, Chen Y. Antioxidants in Chinese medicine. Academic Journal of the First Medical University of PLA 10(suppl 1):491-494, 1990
80. Shen JG, Chen Y, Zhou M, Hou C and Liu Z. Preliminary studies of hyperbaric oxygen induced lipid peroxidation injury. Academic Journal of the First Medical University of PLA 10(4):351-353, 1990
Book Chapters1. Yang D, Sun ZN, Peng T, Wang HL, Shen JG, Chen Y, Tam PKH. Synthetic fluorescent probes
for imaging of peroxynitrite and hypo chlorous acid in living cells. Live Cell Imaging Methods and Protocols. Series: Methods in Molecular Biology Vol 591 (Eds. Papkovsky DB ). Springer USA 2009
2. Feng YB, Chen XM, Wang N, Shen JG. Current Progress on Medicinal Plants and their Biological Properties in Contemporary China. Recent Progress in Medicinal Plants. (Eds. J.N. Govil). Studium Press LLC, Houston, USA 2009 pp 529-588
3. Shen JG. Pharamcology and toxicology of Chinese herbal medicine for improving blood circulation. Pharamcology and Toxicology of Chinese Herbal Medicine. (Eds. Yibin Feng). Commercial Press, Hong Kong 2009
4. Shen JG., Liu S., Miyake M. and Liu K.J., Cerebral tissue oxygenation: transportation, metabolism, measurement, and significance in the ischemic brain. Hyperbaric Oxygen for Neurological Disorders. (Eds. John Zhang). Flagstaff, Arizona, U.S.A., Best Publishing Co. 65-84, 2007
5. Shen JG, Reactive oxygen species and apoptosis. Basic and Clinical Studies of Apoptosis (Eds. Jiang B). People’s Military Medicine Press, Beijing, China 1999
6. Shen JG, Differential diagnostics of sympotoms in Chinese Medicine. Practical Diagnostics in Traditional Chinese Medicine (Eds. Jin SY and Chen SY), People’s Military Medicine Press, Beijing, China 1996
7. Shen JG, Natural antioxidants from herbal medicine and their application in cardiovascular and cerebrovascular disorders. New Forms of Medicine and Clinical Application (Eds. Hou LB), People’s Military Medicine Press, Beijing, China 1996
8. Shen JG, Application of multimedia teaching methods in TCM Diagnostics. Design of Multimedia Teaching Methods in Medicine (Eds. Liu GZ and Lu KD), People’s Military Medicine Press, Beijing, China 1996
9. Shen JG, Zhao B, Li MF, Wan Q, and Xin W. Inhibitory effects of Ginkgo biloba extract (EGb 761) on oxygen free radicals, nitric oxide and myocardial injury in isolated ischemic-reperfused hearts. Proceedings of the International Symposium on Natural Antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, U.S.A. 1996, pp453-465 (Citation 4)
13
Shen JG
10. Zhao B, Shen JG, Hou J, Xin W . Studies on NO free radical generated from ischemia-reperfusion tissue and polymorphonuclear leukocytes (PMN). Modern Applications of EPR/ESR from Biophysics to Material Science (Eds. Rudowicz CZ, Yu KN and Hiraoka H) Springer, 1997
11. Zhao B, Shen JG, Li M, Li M, Wan Q, and Xin W. Chinionin can scavenge NO free radicals and protect myocardia against ischemia-reperfusion injury. Proceedings of the International Symposium on Natural antioxidant: Molecular Mechanisms and Health effects (Eds. Packer L, Traber MG & Xin W), American Oil Chemistry Society Press, Champaign, Illinois, U.S.A. 1996, pp378-391
Patent Reagents for highly specific detection of peroxynitrite, Patent: U.S. CN2006002177
Conference PresentationsInvited Speaker:1. Shen JG. Current Progress in Medical Imaging Diagnosis and Therapeutic Strategies for Stroke :
Opportunities and Challenges for Chinese Medicine. Overseas Excellent Expert Lecture at Hunan University of Traditional Chinese Medicine, November 28, 2011, Changsha, China.
2. Shen JG. Strategical reform for enhancing life-time learning ability for Chinese medical students under globalization of Chinese medicine. Pan- Pearl River Reagion Chinese Medical Education Reform Collaboration Meeting, November 24-27, 2011, Changsha, China.
3. Shen JG. Dual Roles of Caveolin-1 in Cerebral Ischemia and Reperfusion Injury: Protection of Blood Brain Barrier but Inhibition of Neurogenesis. The 17th International Biophysics Congress (IUPAB) & 12th National Biphysical Congress, October 30-November 3, 2011, Beijing, China
4. Shen JG. Acupuncture for post-stroke rehabilitation: Insights form neurobiology, neuroimaging evidence and systemic review of clinical trials. The First Forum of Integrated Neurology, October 29 -30, Beijing, China
5. Shen JG. Drug discovery from herbal medicine for post-stroke treatment. International Symposium on Exploration and Utilization of the Medicinal Plant Resources from Qinling Mountains, May 27-29, 2011, Baoji, China
6. Shen JG. Cancer stem cells: Implications for novel drug development and understanding therapeutic principles of Chinese herbal medicine for cancer treatment., Shanghai International Integrative Medicine Congress. Shanghai, China, 2011
7. Shen JG. Baicalin protects neural cells from cerebral ischemia reperfusion injury by scavenging peroxynitrite, GRC Conference on Oxidative Stress & Disease LA, USA 2011
8. Shen JG. Acupuncture for post-stroke rehabilitation: insights from neurobiological progress, neuroimaging evidence and clinical prospective. Hong Kong Acupuncture International Conference, Neurological and Mental Illness, HKAIC 2011, January 17-19, Hong Kong, China
9. Shen JG. From Traditional Chinese Medicine to Modernization of Chinese Medicine: Rethinking Chinese Medicine education and research direction in Mainland China and Hong Kong. Hong Kong Chinese Medical Strategy Symposium, 2011
10. Shen JG. Interaction of Caveolin-1, Nitric Oxide and Matrix Metalloproteinases Impacts on Blood Brain Barrier Disruption and Infarction in Cerebral Ischemia and Reperfusion Injury, Annual Meeting of Guangzhou, Hong Kong and Macau in Neurology, 2011, Macau, China
14
Shen JG
11. Shen JG. Drug discovery of herbal medicine: Where we are? Where we go? A case study on an herbal formula for treatment of post-stroke disability. International Symposium on Natural Medicine 2010, Dalian, China 2010, 10.10-12
12. Shen JG. Interaction of Caveolin-1 and Nitric Oxide Impacts on Regulation of Blood Brain Barrier Permeability and Infarction Enlargement in Cerebral Ischemia and Reperfusion Injury, Southern Medical University, Guangzhou, 2010. 6.
13. Shen JG. Integration of Multiple Comprehensive Approaches for Understanding Therapeutic Principles of BHD-01 in Post-stroke Treatment, Wuhan Science and Technology University, 2010.4
14. Shen JG. Exploration of Active Components from a Classic TCM Formula for Post-stroke Neurogenesis ___A New Approach for Drug Discovery from Herbal Medicine. TCM Workshop, University of Hong Kong 2010. 7.
15. Shen JG. Integration of multiple comprehensive approaches for exploration of therapeutic principle of BHD-01 in post-stroke treatment, Frontier in Pharmaceutical Studies Series Lectures, Sun Yat-sen University, 2009.4
16. Shen JG. Effects of Buyang Huanwu Decoction on improving neurogenesis and recovery of neurological functions in post-stroke treatment, The 5th Symposium on Collateral Disease Theory, Guangzhou, China, 2009
17. Shen JG, Rosen G.M. and Liu K.J. Development of 3-actoxymethoxycarbonyl- 2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an Electron Paramagnetic Resonance Imaging Reagent for In Vivo Mapping Brain Oxygen Distribution in Ischemic Brain , 6th Annual World Congress for Brain Mapping and Image Guided Therapy, Boston, USA August 26-29, 2009
18. Shen J. Systemical evaluation of Buyang Huanwu Decoction on promoting neurogenesis and functional recovery for post-stroke treatment. TCM Treatment for Aging-related Diseases. Pong Dingyung Symposium for Chinese Medicine. University of Hong Kong. Hong Kong Dec 10-11, 2008
19. Shen J. Seeking for chemical ingredients and molecular targets of Buyang Huanwu Decoction on promoting neurogenesis and functional recovery for post-stroke treatment. Phytochemistry and Chinese Herbal Medicine Analysis Symposium, Shen Zhen, December 5-7, 2008
20. Shen J. Interaction of caveolin-1, nitric oxide, and nitric oxide synthase: A potential signal pathway in regulating neural oxidative injury in hypoxic human SK-N-MC cells and rat ischemic brain. Progress in Biochemistry and Biophysics 35(suppl):151, 2008. The 14th Biennial Meeting of the Society for Free Radical Research International, Beijing. Oct 18-22, 2008
21. Shen JG. Development of novel antioxidant drugs from bench to bedside for treatment of renal ischemia-reperfusion injury. A future prospective for treatment of ischemic acute renal failure. The Third Meeting for Renal diseases with Integrated Medicine, 20-22 September, 2008. Shenzhen, China
22. Shen JG. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH. Characterization of chemical components in Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells. The 7th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Taipei, August 28-30, 2008
15
Shen JG
23. Shen JG. Integration of multiple comprehensive approaches for exploration of therapeutic principle of BHD-01, a Chinese herbal formula, in post-stroke treatment. Invited speaker at Department of Pharamcology, Yale University. 7 May, 2008, New Havern, U.S.A.
24. Shen JG. Current progress and trend in stroke treatment with traditional Chinese medicine. Prevention and Treatment of Common Diseases with Chinese Medicine. Pong Dingyung Symposium for Chinese Medicine. University of Hong Kong. Hong Kong 2007
25. Shen JG., Tong Y. and Liu K.J., Development of electronic paramagnetic resonance imaging: A promising imaging technology for in vivo mapping brain oxygen distribution and infarction in ischemic stroke, 2007 World Congress on Ageing and Dementia in Chinese Community. Hong Kong, 2007
26. Shen JG., Tong Y., Rosen G.M. and Liu K.J., Development of electron paramagnetic resonance imaging: A potential imaging technology for evaluation of traditional Chinese medicine in ischemic stroke, World Congress on Chinese Medicine:Charting the Course of Development. 2006, Hong Kong
27. Shen JG, Xu A, Lee CW, Dan QH, Fung PCW, Lam KS. Adiponectin can inhibit superoxide production, increase superoxide dismutase activity and prevent apoptotic cell death in hypoxic cardiomyocytes. XVIII ISHR World Congress on the Endothelial Factors and Coronary Disease: New Understanding and Effects of Natural Products. August 15-17, 2006. Hong Kong
28. Shen JG, L Tong, CL Liao CL, Fung PCW. Evaluation of Buyang-Huanwu Decoction (BYHWD), a traditional Chinese medicinal formula, against ischemic brain injury in vivo and in vitro. 9th Hong Kong Medical Research Conference, 1, 2004
29. Shen JG, Ma S, Chan S, Cheung RT, Fung PC, Liu KJ. Ischemia-reperfusion induces nitric oxide production and down-regulates caveolin-1 expression in rat brains of middle cerebral artery occlusion. International Workship on EPR studies of viable systems and related techniques. September 19 – 23, 2004 Hanover, New Hampshire, USA
Conference Abstracts1. Shen JG. Interaction of caveolin-1, nitric oxide and matrix metalloproteinases impacts on blood
brain barrier disruption and infarction enlargement in cerebral ischemia-reperfusion injury. 7th World Stroke Conference, Seoul, Kerea, October 13 - 16, 2010
2. Shen JG. Interaction o caveolin-1, cholesterol and nitric oxide synthases in hypoxic human SK-N-MC neuroblastoma cells. 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET. Chicago, IL, June 29 - July 3, 2009. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Volume: 29 Pages: S459-S459 Suppl. S1, 2009
3. Shen JG, Lee W, Chen J. Caveolin-3 peptide prevents apoptotic cell death via preserving superoxide dismutase activity and inhibiting caspase 3 activation in hypoxia-reoxygenated cardiomyocytes. The 4th International Symposium on Healty Aging: Emerging Therapies for an Aging Population. Hong Kong March 7-8, 2009
4. Shen JG, Lee W, Feng Y. Plasma membrane cholesterol homeostasis is essential for modulating caveolin-1 expression and nitric oxide –induced oxidative injury in hypoxic human SK-N-MC neuroblastoma cells. The 6th Asian Biophysics Association (ABA) Symposium& The 27th Hong Kong Society of Neuroscience Annual Meeting, HKUST, Hong Kong Jan 11-15, 2009
16
Shen JG
5. Li Y, DU R, Zhuang P, Shen JG, Zhang Y. Baicalin can promote neuronal differentiation via modulating Jak/Stat3 and Mash1 pathways in rat neural progenitor cells. The 6th Asian Biophysics Association (ABA) Symposium& The 27th Hong Kong Society of Neuroscience Annual Meeting, HKUST, Hong Kong Jan 11-15, 2009
6. Shen JG. Zeng HP, Wang, TT, Chen W, Wang CY, Chen DH. Characterization of chemical components in Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells. The 7th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Taipei, August 28-30, 2008
7. Shen JG, Lee W.S., So K.F. and Tong Y., Nitric oxide stimulates caveolin-1 expression and interaction of caveolin-1 and nitric oxide synthase regulates nitric oxide production in human SK-N-MC neural cells under hypoxia condition Second International Symposium on Healthy Aging: “Meeting the Challenges of an Aging Population”. Hong Kong, 2007.
8. Shen JG., Tong Y. and Tang X.H., Ginkgo biloba extracts (EGb 761) can reduce neurological deficit scores via stimulating neural proliferation and differentiation in transient focal cerebral ischaemic rat brains, 2007 Diet and Optimum Health Conference. Portland, Oregon, U.S.A. 2007
9. Shen JG, Rong JH, Ng KM, Tong Y, So KF, Lau A, Liu J, Tam PKH, Cheng YC. Integration of systemic biology, chemical profile fingerprint and functional imaging technology for understanding therapeutic principle of Chinese medicinal formula: A study on classical post-stroke formula The 6th Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Beijing, China 2008
10. Rong J., Shen JG., Ng K.M., Liu C., Tam P.K.H. and Lau A.S.Y., Application of biological response fingerprinting (BioReF) to define marker genes as potential quality control of botanical drug products, 2006 World Congress on Chinese Medicine (CM2006). Hong Kong, 2006.
11. Rong J., Shen JG., Ng K.M., Liu C., Tam P.K.H. and Lau A.S.Y., Genome-wide biological response fingerprinting (BioReF) enables selection of multiple marker genes as potential quality control of botanical drug products, Fifth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). Zhuhai, China 2006.
12. Rong J., Cheung Y.H., Shen JG., Tam P.K.H. and Lau A.S.Y., Genome-wide biological response fingerprinting (BioReF) of Traditional Chinese Medicine formula ISF-1 reveals a potential role of heme oxygenase-1 pathway in the antioxidant therapy, The 7th International Conference of System Biology. Yokohama, Japan, 2006.
13. Shen JG., Liu B.Y. and Tong Y., Buyang Huanwu Decoction Can Improve Recovery of Neurological Function via Stimulating Neural Proliferation and Differentiation and Modulating VEGF and Flk1 Expressions in Transient Focal Cerebral Ischaemic Rat Brains, 2nd International Symposium on Nutrition, Oxygen Biology and Medicine. Paris, France 2007.
14. Shen JG, Liu SM, Rosen G, Timmins G, Shi HL, Liu KJ. Development of in vivo electron paramagnetic resonance imaging for mapping infarction area and oxygen distribution in ischemic brain. Stroke 37(2):730, 2006
15. KMT Ho, JG Shen, PCW Fung, FCW Lee, PC Tam. Effect of ischemia-reperfusion on nitric oxide production in the pig bladder. European Urology Supplements, Volume 2, Number 1, February 2003, pp. 170-170.
17
Shen JG
16. Chan CP, Shen JG, Fung PC, Cheung RTF. Activation of neuropeptide Y (NPV) Y1 receptors during middle cerebral artery occlusion (MCAO) partly mediates nitric oxide (NO) overproduction from neuronal NO synthase (NOS) in the rat. Stroke 35 (6): E246-E246, 2004
17. Shen JG, Ren J. Chan F, Fung PCW. Extraction of nitric oxide EPR spectra from mixture spectra. International Workship on EPR studies of viable systems and related techniques. Sept 19 – 23, 2004 Hanover, New Hampshire, U.S.A.
18. Dan QH, Xu AM, Shen JG, Lam KS. Adiponectin stimulates the production of manganese superoxide dismutase (SOD2) in human aortic smooth muscle cells. 40th EASD Annual Meeting, Munich, Germany, Sept 16-18, 2004.
19. Wong JC, Lai KW, Cheah KS, Shen JG, Lau CP, Tse HF, Zhang JC. In vivo differentiation of mouse embryonic stem cells in myocardial infraction is a disease-specific process. Annual Meeting of American Heart Association. New Orieans, USA, Sept 2004
20. Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y Y1 receptors, Neurology 62(Suppl 5): A144, 2004.
21. Shen JG, Lu G, Fung PCW, Chu KW. Ultrastructural changes of mitochondria in colorectal adenocarcinoma patients. 9th Hong Kong Medical Research Conference, Hong Kong 1, 2004
22. Shen JG, Lee CW, Fung PCW. Cellular cholesterol accumulation promotes productions of reactive oxygen species and nitric oxide and apoptotic cell death in Chinese hamster ovary (CHO) cells under oxidative stress. 9th Hong Kong Medical Research Conference, 1. 2004
23. Shen JG, Lee CW, Fung PCW. Reactive oxygen species mediate intracellular cholesterol accumulation via modulating caveolin-1 expression in Chinese hamster ovary cells. Stress, Signalling and Control. 679th Biochemical Society Meeting at University of Essex, UK, 63; 2003
24. Shen JG, Fung PCW, Swartz HM. Electron paramagnetic resonance (EPR) oximetry: a novel opportunity for monitoring tissue and cellular oxygen concentration in biological systems in vivo and in vitro. Hong Kong Medical Journal 9(suppl.): 40, 2003
25. Shen JG, Fung PCW, Chang TY. Plasma membrane cholesterol homeostasis is essential for preventing oxidative damage in Chinese hamster ovary cells. Hong Kong Medical Journal 9(suppl.): 40, 2003
26. Shen JG, Fung PCW, Xin WJ, Zhao BL. Nitric oxide contributes to redistribution of phosphatidylserine and triggers apoptosis via p53 and p21/waf-1/cip-1 pathway in hypoxia-reoxygenated cardiomyocytes. Free Radical Biology & Medicine 33: 212 (Suppl.) 1; 2002
27. Fung PCW, Shen JG, Xin WJ, Zhao BL. Ginkgo biloba extract (EGb 761) against hypoxia-reoxygenation-induced cardiomyocytes apoptosis via inhibiting NO/ONOO- pathway and adjusting bcl-2, p53 and p21/waf1/cip1 expressions. Free Radical Biology & Medicine 33: 212 (Suppl.) 1; 2002
28. Shen JG, Khan N, Chang TY, Fung PCW, Grinberg O, Swartz H. Plasma membrane cholesterol is a key molecule in formation of intracellular oxygen gradients in CHO cells. The Hong Kong Practitioner,Journal of Hong Kong College of Family Physicians 24 (2):13,2002
29. Shen JG, Bottle S, Khan N, Reid R, Micallef A, Swartz H. Development of isoindoline nitroxides for EPR oxymetry in viable biological systems. 28th Annual Meeting, International Society on Oxygen Transport to Tissue. Nertherlands, August 2000
18
Shen JG
30. Zhao BL, Shen JG, Hou JW, and Xin WJ. The role of NO and oxygen free radicals in the ischemia-reperfused myocardium: Molecular mechanisms of protection by the bioflavonoid chinonin. 1999 World Congress: Oxidants and Antioxidants in Biology. Santa Barbara, California, USA, March, 1999
31. Shen JG, Wang J, Zhao B, Hou J, Gao T, Xin W. In vivo spin trapping of nitric oxide from ischemia-reperfusion myocardium and effects of L-arginine-NO pathway on myocardial damage and arrhythmias. Japanese Journal of Pharmacology 75(suppl. I): p 152, 1997
32. Shen JG, Wang J, Zhao B, Hou J, Gao T, Xin W. Effects of EGb 761 on generation of nitric oxide, myocardial damage and arrhythmias in ischemia-reperfusion injury in vivo. Japanese Journal of Pharmacology 75(suppl. I): p 239, 1997
19
