CURRICULUM VITAE Dale H. Cowan, MD, JD, FACP ADDRESS: Cancer

CURRICULUM VITAE Dale H. Cowan, MD, JD, FACP

ADDRESS: The Cleveland Clinic Foundation Cancer Center 6100 West Creek Road #15 Independence, Ohio 44131-2133 PHONE: (216)524-7979 FAX: (216)524-8343 E-MAIL: [email protected] EDUCATION: A.B.c.l., Harvard College, 1959 M.D., Harvard Medical School, 1963 J.D., Case Western Reserve University, 1981 CURRENT POSITION: Director, Regional Programs Cleveland Clinic Cancer Center ACADEMIC APPOINTMENTS:

1985 - Clinical Professor of Environmental Health Sciences Case Western Reserve University

1983 - 1984 Clinical Professor of Epidemiology and Community Health Case Western Reserve University 1978 - 1982 Director, Division of Medical Oncology and Hematology - Department of Medicine, and Medical Coordinator of the Multidisciplinary Cancer Unit, St. Luke’s Hospital, Cleveland, Ohio

1980 - 1985 Lecturer in Law Medicine, Case Western Reserve University School of Law, Cleveland, Ohio 1975 - 1983 Associate Professor of Medicine, Case Western Reserve University 1970 - 1975 Assistant Professor of Medicine, Case Western Reserve University 1975 - 1978 Associate Physician, Cleveland Metropolitan General Hospital, Cleveland, Ohio

Dale H. Cowan, M.D. Curriculum Vitae

1970 - 1975 Assistant Physician, Cleveland Metropolitan General Hospital, and Assistant Physician University Hospitals of Cleveland TRAINING: 1968 - 1970 USPHS Trainee in Hematology, Cleveland Metropolitan General Hospital - Case Western Reserve University, School of Medicine 1968 -1969 Chief Resident in Medicine, Cleveland Metropolitan General Hospital (4/1/69 - 6/30/99) 1967 - 1968 Senior Assistant Resident in Medicine, Cleveland Metropolitan General Hospital 1965 - 1967 Clinical Associate, USPHS, Clinical Hematology Branch,

NIAMID, National Institutes of Health, Bethesda, Maryland 1964 - 1965 Assistant Resident in Medicine, Cleveland Metropolitan General Hospital 1963 - 1964 Internship, straight medical, Cleveland Metropolitan General Hospital LICENSURE: MEDICINE LAW Ohio, August, 1964 Ohio Bar, May, 1981 California, June, 1969 CERTIFICATIONS: July 1965 National Board of Medical Examiners October 1969 American Board of Internal Medicine October 1972 American Board of Internal Medicine, Subspecialty Certification in Hematology October 1975 American Board of Internal Medicine, Subspecialty Certification in Medical Oncology DIRECTORY LISTINGS: Who’s Who in America

Who’s Who in the World Who’s Who in Medicine and Healthcare AWARDS:

1995 David J. Greenburg Service Award, National Health Lawyers Association

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ACTIVITIES:

1973 – 1976 Investigator, Eastern Cooperative Group (ECOG) Member, Cancer Center, Inc. 1976 – 1996 Senior Investigator (ECOG) 1976 – 1989 Member, Steering Committee of Cancer Control Program 11/1997 Chairman and Moderator, Cancer Control Workshop on Legal

Aspects of the Diagnosis and Management of Cancer (ECOG) 4/1979 Chairman and Moderator, Workshop on Supportive Care of the

Cancer Patient, Northeast Ohio Society of Clinic Oncology Chairman and Moderator, Cancer Control Workshop on Informed

11/1979 Consent (ECOG) Organizer, Educational Symposium on Ethical and Financial Issues 6/1989 in Innovative Cancer Treatment (ECOG)

SOCIETIES: (MEDICINE) Fellow, American College of Physicians

Fellow, American College of Legal Medicine American Society of Hematology American Heart Association, Council on Thrombosis American Society of Clinical Oncology American Association for Cancer Research American Association for the Advancement of Science Cleveland Academy of Medicine American Medical Association International Society on Thrombosis and Hemostasis American Society of Law and Medicine American College of Physician Executives

OFFICES:

1973 – 1976 Secretary-Treasurer, Medical Staff, Cuyahoga County Hospitals 1975 – 1978 Chairman, Committee on Investigation in Humans, Cleveland Metropolitan General Hospital 1976 – 1978 Chairman, Utilization Review Committee, Department of Medicine,

Cleveland Metropolitan General Hospital 1976 – 1981 Chairman, Phase II Hematology Committee, Case Western Reserve University (CWRU) School of Medicine

1976 – 1980 Chairman, Ethical Review Committee (ECOG) 1987 – 1991 Chairman, Ethical Review Committee (ECOG) 1992 - 1996 Chairman, Ethical Review Committee (ECOG) 1978 – 1980 Chairman, CWRU Council on Human Research 1979 – 1984 Chairman, Dying Patient Committee, Cleveland Academy of Medicine

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1979 – 1981 Chairman, Cancer Committee, St. Luke’s Hospital 1979 - 1983 Chairman, Nellie Westerman Prize Committee, American Federation

for Clinical Research 1981 – 1982 President, Northeast Ohio Society of Clinical Oncology

1982 - 1983 Vice-President, Physicians Peer Review Organization 1983 - 1984 President, Northern Ohio Health Providers Organization

1987 - 1988 President, Northern Ohio Health Providers Organization 1985 – 1987 Treasurer, Medical Staff, Marymount Hospital 1987 – 1989 Secretary, Medical Staff, Marymount Hospital 1984 – 1989 Chairman, Institutional Review Board, Bellefaire/Jewish Children’s Bureau 1981 – 1997 Director, Hematology/Oncology and Chairman, Cancer Committee,

Marymount Hospital, Cleveland, Ohio 1987 – 1996 Chairman, Institutional Review Board, Marymount Hospital 1994 - Chairman, Ethics Committee, Marymount Hospital

1988 – 1990 Chairman, Forum on Law, American College of Physician Executive 1989 – 1996 Chairman, Cancer Committee, Parma Community General Hospital

1989 – 1990 Chairman, Professional Standards Committee, Parma 1991 – 1993 Chairman, Administrative Affairs Committee, Parma Community General Hospital 1991 – 1993 Chairman, Clinical Risk Committee, Parma General Hospital 1991 – 1994 President, Ohio/West Virginia Oncology Society 1997 – 1998 President of Medical Staff, Parma Community General Hospital 1997 – 1998 President, Academy of Medicine of Cleveland 1999 – 2001 Chairman, Board of Trustees, Northern Ohio Cancer

Resource Center EDITORIAL POSITIONS: Member, Editorial Board, IRB Member, Editorial Board, Journal of Legal Medicine Member, Editorial Board, Medical Staff Counselor

Member, Editorial Board, Alcoholism - Clinical and Experimental Research (1977 – 1982)

Member, Editorial Board, Health Matrix (1980 – 1982) Editor, Medical Staff Management, Rynd Communications National

Health Publishing, Baltimore, MD COMMITTEES: General Research Support Grant Review Committee Case Western

Reserve University (1975 – 1981) American Cancer Society Institutional Grant Review Committee Case Western Reserve University (1975 – 1981)

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Scientific Advisory Committee, American Cancer Society, Cuyahoga

Society County Unit (1975 – Peer Norms Committee, Cleveland Academy of Medicine

(1976 – 1978) Public Policy and Legislation Committee, Cleveland Academy of Medicine (1976 – 1978) Clinical Research Committee, American Society of Clinical

Oncology (1976 – 1978) Nellie Westerman Prize Committee, American Federation for Clinical Research (1977 – 1983) Technical Advisory Committee, Cancer Data System Greater Cleveland Hospital Association (1979 – 1982) Clinical Practices Committee, American Society of Clinical Oncology (1982– 1990) Member, Subcommittee on Reimbursement, Quality Assessment, and CPT-4 Editorial Changes Patient Care Evaluation Committee, Parma Community General

Hospital (1989 – 1992) Cancer Committee, Deaconess Hospital (1991 - 2000)

BOARD POSITIONS: Organizing Board of Directors, Emerald Health Network (1983)

Board of Trustees, Physicians Peer Review Organization (1981 – 1983) Board of Trustees, Health Care Review Organization (1982 – 1983) Board of Directors, American Society of Law and Medicine (1982 –1983) Board of Trustees, American Heart Association - Northeast Ohio Chapter (1983 – 1985) Board of Directors, National Health Lawyers Association (1988 – 1991) (1991 – 1994) Board of Directors, Innova Medical Services, Inc. (1993 – 1995) Board of Directors, Academy of Medicine of Cleveland (1994 – 1999) Board of Trustees, Northern Ohio Cancer Resource Center (1998 - 2001) Member, Board of Governors, American College of Legal Medicine (ACLM) 2001 - 2004

SOCIETIES: Greater Cleveland Bar Association (LAW) Ohio State Bar Association

American Health Lawyers Association American Society of Law and Medicine

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ADVISORY POSITIONS: Member, National Advisory Council of the National Heart, Lung and

Blood Institute, National institutes of Health, Department of Health and Human Services, Presidential Appointment (1981 – 1985) Special Consultant to the President’s Commission on Bioethics (1981) Member, Advisory Committee of the Center for Professional Ethics, Case Western Reserve University (1982 – 1985) Member, Scientific Advisory Committee on Cancer, Cancer Data System Inc. (1980 – 1983) Associate, Health Systems Management Center, Case Western Reserve University (1982 – 1989)

Member, Regional Advisory Committee, Regional Cancer Resource Center, Case Western Reserve University

(1985 - 1989) Panel Member: Consensus Development Conference on The Impact of Routine HTLV-III Antibody Testing of Blood and Plasma Donors on Public Health. Sponsored by the National Institutes on Health, the NIH Office of Medical Applications of Research, the Center for Disease Control, the Food and Drug Administration.

Bethesda, MD (July 7-9, 1986) Member, Human Fetal Tissue Transplantation Research Panel, Consultations to the Advisory Committee to the Director, National Institutes of Health, Bethesda, MD (1988)

SPECIAL LECTURES:

1. Guest Speaker: Legal Implications of a Quality Assurance Program. Quality Assurance Utilization Review Seminar. Cleveland Metropolitan General Hospital, June 8, 1976.

2. Chairman and Moderator, Cancer Control Workshop on Legal Aspects of the Diagnosis

and Management of Cancer. Eastern Cooperative Oncology Group (ECOG), Chicago, IL November 1977.

3. Chairman and Moderator, Cancer Control Workshop on Informed Consent. Eastern

Cooperative Oncology Group, Cleveland, Ohio November 1977. 4. Keynote Address: Legal Issues Affecting Health Care for the Elderly. Conference on

Health Care for the Elderly sponsored by Center for Aging. Case Western Reserve University, June 19, 1981.

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5. Faculty and Guest Speaker, Workshop on Institutional Review Boards and Human

Subjects Research. Sponsored by the Hastings Center for Society, Ethics and the Life Sciences, Colorado, Co., July 12-18, 1981.

6. Guest Speaker, Conference on Privacy and Confidentiality: Can They be Protected?

Sponsored by Public Responsibility in Research and Medicine, Boston, MA, October, 1981.

7. Guest Speaker: Legal Consequences of Prescribing an Approved Drug for a non-

Approved Use. Community Health Grand Rounds, Cleveland Urban Area Health Education Center, Cleveland, Ohio, December 16, 1981.

8. Guest Speaker: Randomized Clinical Trials. Research in the 80’s. A Symposium

presented by the Bronson Clinical Investigational Unit and sponsored by The Upjohn Company. Augusta, Michigan, March 2, 1982.

9. Guest Speaker: How to Review Medical Records. Seminar on Hospital and Medical

Liability. Continuing Legal Educational Program, Cleveland Marshall School of Law Cleveland State University, Cleveland, Ohio, June 2, 1982.

10. Guest Speaker: Compensation for Research-Related Injuries. Research on Special

Populations. Sponsored by PRIM & R, Boston, Massachusetts, October 11, 1982. 11. Faculty and Guest Speaker: Ethical Controversies at the End of Life. Sponsored by

the Center for the Critically Ill. Beachwood, Ohio, October 28, 1982. 12. Guest Speaker: Competition in Health Care: What’s In It For You? Meeting of

Harvard University Club of Cleveland. January 26, 1983. 13. Guest Speaker: Preferred Provider Organizations at Seminars on Competition – A

Question of Survival. Sponsored by the Academy of Medicine of Cleveland. Cleveland, Ohio. March 23, 1983.

14. Faculty and Guest Speaker: Alternative Organization for Medical Practice. 23rd

International Conference on Legal Medicine. Sponsored by American College of Legal Medicine. Kona, HI, May 9, 1983.

15. Faculty and Guest Speaker: Hospital Responsibility for Innovative Therapy. 23rd

International Conference on Legal Medicine. Sponsored by American College of Legal Medicine. Kona, HI, May 1983.

16. Guest Speaker: An In-Depth Look at PPO’s Seminar on Survival in an Era of

Competition. Sponsored by The Cleveland Dental Society. Cleveland, Ohio, June 7, 1983.

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17. Guest Speaker: Preferred Provider Organizations. Medical Grand Rounds. Lutheran

Medical Center. Cleveland, Ohio. June 15, 1983. 18. Guest Speaker: Physicians-Sponsored PPO’s. Seminar on Hospital Involvement with

Preferred Provider Organizations (PPO’s). Sponsored by Ohio Hospital Association. Columbus, Ohio. June 21, 1983.

19. Faculty: Symposium on Preferred Provider Organizations. Sponsored by National

Health Lawyers Association. Topic: Business Consideration in PPO Contracting – from the PPO Perspective. Washington, DC, September 22, 1983.

20. Faculty: Symposium on Contracts for Health Care Providers. Sponsored by National

Health Lawyers Association. Topic: PPO Contracts. Crystal City, VA. October 3, 1983.

21. Faculty: Symposium on Contracts for Health Care Providers. Sponsored by National

Health Lawyers Association. Topic: PPO Contracts. Crystal City, VA, October 3, 1983.

22. Faculty: Conference on Competition, Economic Change and Antitrust Issuer in the

Health Care Industry. Sponsored by the American Bar Association. Topic: Practical Suggestions and Models for Establishing and Operating PPO’s, MeSHs, and Other Alternative Delivery Systems. New Orleans, LA, February 2-4, 1984.

23. Guest Speaker: 1984 Governor’s on Alternative Health Delivery system. Sponsored by

the Pennsylvania Department of Health. Topic: Physician Participation in Sponsorship of HMO’S/PPO’S. Hershey, PA, April 30 - May 1, 1984.

24. Faculty: Symposium on Tax Problems of Nonprofit Health Care Organizations.

Sponsored by The National Health Lawyers Association. Topic: Preferred Provider Organizations. Toronto, Canada, November 9, 1984.

25. Guest Speaker: Healthcare Perspectives - Transition Continues. Sponsored by the

American Marketing Association. Topic: Review of Alternative Delivery Systems: Potential & Problems. Cleveland, Ohio, November 28, 1984.

26. Faculty: Update on Protection of Human Subjects and Institutional Review Boards.

Sponsored by U.S. Food and Drug Administration and State University of New York at Buffalo. Topic: Review of Multi-Institutional Clinical Trails. Buffalo, NY, November 29, 1984.

27. Faculty: Conference on Antitrust in the Health Care Field. Sponsored by the

National Health Lawyers Association. Topic: Joint Ventures - Hospitals and Physicians. Washington, D.C., January 23-25, 1985.

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28. Faculty: Conference on Medical Staff Legal Issues. Sponsored by the National Health

Lawyers Association. Topic: Practical Application as to the Delineation of Clinical Privileges. Miami, FL, March 3-5, 1985.

29. Speaker: Professional Survival in the Eighties - HMO’S PPO’s and DRG’s.

Sponsored by Rhode Island Group Hospital Association. Memorial Hospital, Pawtucket, RI. March 8, 1985.

30. Speaker: Health Law Luncheon Series. Sponsored by the Health Law Section of the

Bar Association of Greater Cleveland. Topic: Privileging and Credentialing of Hospital Medical Staff. Cleveland, Ohio March 19, 1985.

31. Speaker: Conference on HMO Issues 1985: A Seminar for State Regulators.

Sponsored by Aspen Systems Corporation. Topic: PPO’s, CMPs, Joint Ventures. Hilton Head, SC., March 21, 1985.

32. Co-organizer, Moderator, and Speaker: Conference on Legal and Ethical Issues

Surrounding Organ Transplantation. Sponsored by American College of Legal Medicine, American Society of Law & Medicine, and the National Heart, Lung and Blood Institute. Topic: Regulation of Medical Practice. Arlington, VA., April 18-20, 1985.

33. Speaker: Conference on PPO’s - Lessons from Success. Sponsored by the

American Association of Preferred Provider Organizations. Topic: Physician - Based PPO Strategies. Washington, D.C., April 19, 1985.

34. Speaker: Health Care Law Seminar. Sponsored by the Health Law Section off the Bar

Association of Greater Cleveland. Topic: Alternative Delivery Systems. Cleveland, Ohio, April 26, 1985.

35. Organizer and Speaker: NIH/FDA Regional Workshop on The Protection of Human

Subjects. Sponsored by The School of Medicine and The Law/Medicine Center of The School of Law of Case Western Reserve University and Northeast Ohio Universities College of Medicine. Topics: The IRB’s Role and Scope: Implementing the Principles of Risk/Benefit Analysis and Informed Consent; Concern with Scientific Design: Where is the Point of No Return? Cleveland, Ohio, April 27, 1985.

36. Faculty: Conference on Professional Competition and Survival in the Eighties. Sponsored by the American College of Legal Medicine. Topic: Joint Ventures Between Hospitals and Physicians. New Orleans, LA, May 11, 1985.

37. Speaker: Symposium on Clinical Practice. Sponsored by the American Society

of Clinical Oncology. Topic: Legal Issues Affecting Oncology Practice. Houston, TX, May 19, 1985.

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38. Speaker: Conference on American Bar Association Tort and Insurance Practice.

Sponsored by the American Bar Association. Topic: Innovative Therapy Versus Experimentation. Washington, D.C., July 8, 1985.

39. Faculty: Conference on Legal Issues in Transfusion Medicine. Sponsored by the

National Health Lawyers Association and the American Association of Blood Banks. Washington, D.C., September 19, 1985.

40. Faculty: Conference on Medical Malpractice in New York: Current Crisis and Future

Trend. Sponsored by Center for Law and Health, Benjamin N. Cardozo School of Law. Topic: Innovative Therapy and Standards for Medical Practice: Implications for Malpractice Liability. New York, NY., September 20, 1985.

41. Luncheon Speaker: Seminar on Health Care Contracts. Sponsored by Columbus Bar

Association, Health Care Law Committee. Topic: Future Trends in Medical Practice. Columbus, Ohio, September 27, 1985.

42. Faculty: Inaugural National Medical Staff Conference. Sponsored by American

Medical Association. Topic: Credentialing: Establishing Who Will Practice in the Hospital. Washington, D.C., October 18, 1985.

43. Faculty: Seminar on Antitrust in The Health Care Industry. Sponsored by Ohio State

Bar Association, Sections on Antitrust and on Health Law. Topic: Medical Staff By-Laws and Credentialing. Columbus, Ohio, October 25, 1985.

44. Faculty: Second Institute on Health Contracts. Sponsored by National Health Lawyers

Association. Topic: Preferred Provider Organization Contracting. Philadelphia, PA., November 12, 1985.

45. Co-Chairman and Speaker; National Symposium and Workshop to explore Hospital

and Physician Relationships in the Decade Ahead. Sponsored by the American Academy of Hospital Attorneys. Topic: Legal/Ethical Issues of Changing Medical Practices. New Orleans, LA, November 18-19, 1985.

46. Faculty: Conference on Legal and Operational Issues of HMO’s, PPO’s & CMP’s.

Sponsored by the National Health Lawyers Association. Topic: Physician-Sponsored Preferred Provider Organizations. Chicago, IL, December 12, 1985.

47. Speaker: Hospital-Physician Relationships: The Decade Ahead. Sponsored by the

Office of Community Health. Case Western Reserve University School of Medicine. Cleveland, Ohio, January 22, 1986.

48. Faculty: Practice Management and Marketing Seminar. Sponsored by Academy of Medicine of Cleveland. Topic: Contracting with Alternative Delivery Systems (HMO’S, IPA’s & PPO’s). Cleveland, Ohio, April 26, 1986.

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49. Faculty: Blue Cross and Blue Shield National Health Care Institute. Sponsored by the

Blue Cross and Blue Shield Association and the Program and Bureau of Hospital Administration, the University of Michigan. Topic: Legal Issues in Plan Management. Ann Arbor, MI, June 10, 1986.

50. Faculty: Data Managers Educational Session. Sponsored by Eastern Cooperative

Oncology Group. Topic: Legal Issues in Informed Consent. Chicago, IL, June 19, 1986.

51. Faculty: Workshop on The Business of Managing Healthcare: Critical Issues for

Survival. Sponsored by MedEcon Services, Inc. Topic: How to Negotiate and Effective HMO/PPO. Cincinnati, Ohio. June 20, 1986.

52. Speaker: Privileging and Credentialing of Non-Physician Professionals. Address to

Oregon Medical Association - Hospital Medical Staff Section. Portland, Oregon, November 7, 1986.

53. Speaker: Credentialing and Quality Assurance. Address to Missouri Medical

Association - Hospital Medical Staff Section. Columbia, MO. January 31, 1987. 54. Speaker: Continuing Medical Education Program. Piqua Memorial Medical Center.

Topic: The Credentialing Process. February 5, 1987. 55. Key note Speaker: “Tricks of the Trade” Cancer-Related Screening and Prevention.

Queen on the Valley Hospital. Topic: Obligations and Risks: The Law and You. West Covina, CA. June 27, 1987.

56. Faculty: Health Care Institute. Contracts by Health Professionals with Alternative

Delivery Systems. Sponsored by National Health Lawyers Association. General Session Address. Boston, MA. November 9, 1987.

57. Faculty: National Institute on Health Care Leadership and Management. Sponsored by

American Academy of Medical Directors. Course 7: Essentials of Contracting: Employment and Personal Services. Tucson, AZ. November 17-18, 1987.

58. Speaker: Forum on the Practice of Hematology. Topic: Managed Medicine and

Vertical Integration: The Hospital’s Position - The Hematologist Position - Are They Compatible. 29th Annual Meeting American Society of Hematology, Washington, D.C., December 5, 1987.

59. Faculty: Physician Recruitment, Retention, and Incentives: A Practical Approach.

Sponsored by the National Health Lawyers Association. Topic: Medical Staff issues. Washington, D.C., February 25, 1988.

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60. Faculty: Progressive Approaches to Breast Cancer: A Symposium. Sponsored by

Parma Community General Hospital. Topic: Role of Chemotherapy and Radiation Therapy in the Management of Breast Cancer. Cleveland, Ohio, May 7, 1988.

61. Faculty: Protection on Human Subjects in Healthcare Research. Sponsored by Case

Western Reserve University. Topic: Monitoring Human Research. Cleveland, Ohio, May 10, 1988.

62. Faculty: National Institute of Health Care Leadership and Management. Sponsored by

American Academy of Medical Directors. Course 4: Essentials of Health Law for Managing Legal Counsel. Fort Lauderdale, FL, November 14-18, 1988.

63. Co-Chairman and Faculty: Legal Issues in Organ Transplantation. Sponsor: The

National Health Lawyers Association. Washington, D.C., February 23-24, 1989. 64. Chairman and Moderator: Forum on Law and Medicine Workshop. Sponsor: The

American College of Physician Executive. Washington, D.C., May 3, 1989. 65. Co-Chairman and Faculty: Drugs, Devices, and Biotechnology: Legal Issues.

Sponsor: National Health Lawyers Association. Baltimore, MD, October 30-31, 1989. 66. Faculty: Health Contracts - Negotiating in the 1990’s. Sponsor: National Health

Lawyers Association. Topic: Employer and Employee Contracting -Among Physicians, B) Between Physicians and Other Health Care Providers. Chicago, IL, November 9-10, 1989.

67. Faculty: Physician’s Survival Guide: Legal Pitfalls and Solutions. Sponsor: National

Health Lawyers Association. Topic: Contracts Between Physicians and Hospitals. San Diego, CA, April 10-20, 1991.

68. Faculty: Oncology in the 1990’s. Practice Issues with Chemotherapy. Sponsor: The

Cleveland Clinic Cancer Center, Department of Experimental Therapeutics. Cleveland, Ohio, September 24, 1991.

69. Faculty: The New Medical Staff Legal. Legal Issues Update. Sponsor: The National Health Lawyers Association. Chicago, IL, September 27-28, 1991.

70. Faculty: Health Law Update and Annual Meeting. Sponsor: National Health Lawyers Association. Topic: The Role of the Medical Staff Counsel: A Physician’s Perspective. Laguna Niguel, CA, June 10-12, 1992.

71. Speaker: Coagulation Disorders. Parma Community General Hospital, CME

Presentation. June 23, 1992.

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72. Faculty: The Medical Staff: Current Legal Issues in a Changing Delivery System.

Sponsor: National Health Lawyers Association. Topic: Physician-Hospital Organizations. Chicago, IL November 1-2, 1993.

73. Speaker: Medical Futility. Sponsor: Meridia Hillcrest Cancer Center, Cleveland,

Ohio, April 23, 1994.

74. Co-Moderator: Colloquium on Legal Issues Related to Clinical Practice Guidelines. Sponsor: National Health Lawyers Association. Washington D.C, July 9, 1994.

75. Speaker: Practice Parameters: Adversarial or Beneficial? Sponsor: Physician

Insurers Association of America. Orlando, FL. June 2, 1995.

76. Speaker: Legal Aspects of Clinical Guidelines. Sponsor: Physician Executives of Northeast Ohio. Cleveland, Ohio, September 13, 1995.

77. Speaker: Medicare and Managed Care. Sponsor: Albany Law School, Topic:

National Legal Trends Practice Perspective. Albany, NY, November 3, 1995.

78. Speaker: The Amgen Physician Oncology Preceptorship Program. Sponsor: The Cleveland Clinic Foundation and The Cleveland Clinic Cancer Center. Topic: Medical Oncology and Managed Care. Cleveland, Ohio, March 1-2, 1996.

79. Speaker: Physician Relations - Practice Acquisition, Physician Alliances, Quality

Outcomes, Industry Consolidation. Sponsor: The Northeast Ohio Chapter of the Healthcare Finance Management Association. Topic: Buying Doctors- The Return of Indentured Servitude. Cleveland, Ohio, March 19, 1996.

80. Faculty: Physicians and Hospitals: Business Transactions and Medical Staff Issues.

Sponsor: The National Health Lawyers Association. Topic: Organizing Physician Specialty Networks. Atlanta, Georgia, April 17-19, 1996.

81. Speaker: Managed Oncology Care. Sponsor: International Business

Communications. Topic: Community vs. Hospital Initiated Oncology Networks. Lake Buena Vista, FL, September 19-20, 1996.

82. Speaker: Building Bridges to Oncology in the 21st Century. Sponsor: Association

of Community Cancer Centers. Topic: Regional Oncology Networks. Washington, D.C, March 19-22, 1997.

83. Speaker: Survival Strategies for Oncologists in the Managed Care Area. Sponsor:

The Institute for Medical Studies. Topic: Developing Non-Hospital Groups. Oakbrook, IL, April 19, 1997.

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84. Speaker: New Perspectives in Research and Treatment: Antifolates in Malignancies.

Sponsor: ProED Communications, Inc. Topic: Reimbursement Initiatives for New Agent’s in the Treatment of Malignancies. Philadelphia, PA, May 2, 1998.

85. Speaker: Fundamentals of Governance. Sponsor: Health Trustee and Leadership

Institute, The Center for Health Affairs. Topic: Organization of the Medical Staff. Cleveland, Ohio, June 2, 1998.

86. Speaker: The Changing System of Health Care…From a Physician Perspective.

Sponsor: Lake to River Health Care Coalition. Annual Luncheon Meeting, Warren, Ohio, June 16, 1998.

87. Speaker: The Unionization of the Medical Profession. Sponsor: Faculty-Staff

Public Affairs Discussion Group, Case Western Reserve University. Cleveland, Ohio, August 27, 1999.

88. Speaker: Current Issues in Unionizing Physicians. Sponsor: Industrial Relations

Research Association. Cleveland Ohio, September 23, 1999.

89. Program Moderator: Oncology Update 1999. Sponsor: Parma Community General Hospital. Cleveland, Ohio, October 27, 1999.

90. Speaker: Duties of Medical Staff Leaders. Medical Staff Leadership Seminar.

Sponsor: St. John West Shore Hospital, Westlake, Ohio. February 23, 2000.

91. Program Moderator: Radiation Oncology Symposium and Speaker: Update on Management of Lung Cancer. Sponsor: Parma Community General Hospital, Parma, Ohio. May 24, 2000.

BIBLIOGRAPHY Original Articles - Medicine

1. Libre EP, Cowan, DH, Watkins, SP, Jr. and Shulman, NR: Relationships between

spleen, platelets and factor VIII levels. Blood 31:358-369, 1968.

2. Hines JD and Cowan DH: Studies on pathogenesis of alcohol-induced sideroblastic bone marrow abnormalities. N Eng J Med 283:441-446, 1970.

3. Cowan DH and Hines, JD: Thrombocytopenia of severe alcoholism. Ann Int Med

74:37-43, 1971. 4. Cowan DH and Haut MJ: Platelet function in acute leukemia. J Lab Clin Med

79:893-905, 1972.

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5. Cowan DH: Thrombokinetic studies in alcohol-related thrombocytopenia. J Lab

Clin Med 81:64-76, 1973.

6. Cowan DH and Hines JD: Thrombokinetics in dietary induced folate deficiency in human subjects. J Clin Med 81:577-586, 1973.

7. Cowan, DH: Platelet Metabolism in acute Leukemia. J Lab Clin Med 82:54-66,

1973.

8. Haut MJ, Cowan DH, Harris, JW: Platelet function and survival in sickle cell disease. J Lab Clin Med 82:44-53, 1973.

9. Haut, MJ and Cowan DH: Effect of ethanol on hemostatic properties of human blood

platelets. Am J Med 56:22-23, 1974.

10. Cowan, DH: Thrombokinetics in acute non-lymphocytic leukemia. J Lab Clin Med 82:911-923, 1973.

11. Cowan, DH: Platelet metabolism in alcohol-related thrombocytopenia. Thromb

Diath Haemorrh 31:149-159, 1974.

12. Cowan DH and Graham RC, Jr.: Structural-functional relationships in platelets in acute leukemia and related disorders. Ser Haemat 8:68-100, 1975.

13. Cowan DH, Graham RC, Jr, and Baunach, D: The platelet defect in leukemia.

Platelet ultrastructure, adenine nucleotide metabolism, and the release reaction. J Clin Invest: 56:188-200, 1975.

14. Cowan DH: The platelet defect in alcoholism. In: Symposium on Medical Aspects

of Alcoholism. Ann NY Acad Sci 252:328-341, 1975.

15. Cowan DH and Graham, RC, Jr.: Studies on the platelet defect in alcoholism. Thromb Diath Haemorrh 33:310-327, 1975.

16. Czarnetzki B, Cowan, DH and Belcher, RW: The effect of polyanions on NBT

reduction, hexose monophosphate shunt activity and ultrastructure of polymorphonuclear leukocytes. Am J Clin Pathol 64:34-40, 1975.

17. Cowan DH, Graham, RC Jr., Shook, P and Griffin, R: The influence of

ascorbic acid on platelet structure and function. Thromb Diath Haemorrh 34:50-62, 1975.

18. Sokol RJ, Reed GB, Cowan DH and Hutcheson, P: Amelanotic malignant melanoma

metastatic to the placenta. Am J OB-GYN 124:431-432, 1976.

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19. Cowan DH, Bowman LS, Fratianne, RB and Ahmed, F: Platelet aggregation as a

sign of septicemia in patients with thermal injury. J Am Med Assoc, 235:1230-1234, 1976.

20. Cowan DH, Graham RT Jr, and Shook P: Hyperosmolality - a factor in ethanol-

related platelet dysfunction? Sem in Hematol 13:103-114, 1976.

21. Walton AG, Solomon D and Cowan DH: Interaction of blood platelets with synthetic copolypeptide films. In: Colloid and Interface Science, Vol. V., Academic Press, 1976. New York, San Francisco, London. Pgs. 1-21.

22. Schwartz AL, Polmar SH, Stern RC, and Cowan DH: Abnormal platelet

aggregation in severe combined immunodeficiency disease with adenosine deaminase deficiency. Brit J Haematol 39:189-194, 1978.

23. Walton AG, Soderguist MD, Solomon DD, Cowan DH and Gersham H: Attachment

of cells to copolypeptide films. Polymer Preprints 20:24-26, 1979.

24. Thorgeirsson G, Robertson AL Jr, and Cowan DH: Migration of human vascular endothelial and smooth muscle cells. Laboratory Investigation 45:765-782, 1979.

25. Solomon DD, Cowan DH, Anderson JM and Walton AG: Platelet interaction with

synthetic copolypeptide films. J Biomater Res 13:765-782, 1979.

26. Cowan DH, Robertson AL, Shook P and Giroski P: Platelet adherence to collagen: Role of plasma, ADP, and divalent cations. Brit J Haematol 47:257-267, 1981.

27. Cowan DH: Platelet adherence to collagen: role of prostaglandin thromboxane

synthesis. Brit J Haematol 49:425-434, 1981.

28. Cowan DH and Graham J: Effect of platelet lysate on growth of human tumor colonies. In: Interaction of Platelets and Tumor Cells. Progress in Clinical and Biological Research Vol. 89. Ed. By G. Jamieson. Alan R. Liss, Ins., New York, 1982, 99:249-268.

29. Cowan DH and Graham J: Stimulation of human tumor colony formation by platelet

lysate. J Lab Clin Med 102:973-986, 1983.

30. Cowan DH, Graham J, Paskevich MC, and Quinn PG: Influence of platelet lysate on colony formation on human breast cells. Breast Cancer Res Treat 3:171-178, 1983.

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Review Articles - Medicine

1. Shulman NR, Cowan DH, Libre EP, Watkins SP Jr, and Marder VJ: Clinical Staff Conference: The physiologic basis for therapy of classic hemophilia (factor VIII deficiency) and related disorders. Ann Int Med 67:856-882, 1967.

2. Cowan DH and Hines JD: Alcohol, vitamins and platelets. In: Dimitrov,

NV and Nodine JH (eds.), Drugs and Hematologic Reactions, 29th Hahnemann International Symposium. New York: Grune & Stratton, 283-295, 1974.

3. Hines JD and Cowan DH: Anemia and alcoholism. In: Dimitrov, NV and Nodine

HH (eds.), Drugs and Hematologic Reactions, with Hahnemann International Symposium. NewYork: Grune & Stratton, page 141-153, 1974.

4. Cowan DH: Acquired disorders of platelet function. In: Colman RW, Hirsch J,

Marder VJ and Salzman EW (eds.), textbook of Hemostasis and Thrombosis. J.B. Lippincott Co., Philadelphia, Pennsylvania. Pgs. 516-524.

5. Cowan DH: Effects of alcoholism on hemostasis. Sem Hematol 17:137-147, 1980.

Original Articles - Law/Ethics

1. Cowan DH: Human experimentation: The review process in practice. 25 Case

Western Reserve Law Review, 533-564, 1975.

2. Cowan DH: Ethical consideration of metabolic research in alcoholic patients. Alcoholism. Clinical and Experimental research, 193-198, 1977.

3. Levine RJ and Cowan DH: Ethical consideration in clinical trials. In: Proceedings

of the National Conference on Clinical Trials Methodology. 25(2) Clin Pharm & Ther 728-746, 1979.

4. Cowan DH and Adams BR: Research with medical records: Ethical and legal

considerations for IRBs. 1 IRB 1-4, 8, 1979.

5. Cowan DH: Research on the therapy of cancer with comment on IRB review of multi-institutional trials. In Human Subjects Research. Edited by R.A. Greenwald, MK Ryan, JE Mulvihill. Plenum Publishing Corporation, New York, 1982, pp. 151 - 167.

6. Cowan DH: Randomized clinical trials. Procedural issues for IRB’s. 2(9) IRB 1-4,

1980.

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7. Cowan DH: Tort liability of patentee licensor. 64 J Patent Office Soc 87-104, 1982.

8. Cowan DH: Large Scale Clinical Trials. In: Guidebook for Institutional Review

Boards. The President’s Commissions for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Washington, DC 1983.

9. Cowan DH: Legal consequences of prescribing an approved drug for a non-approved

use. Health Matrix 51 - 57, 1983.

10. Cowan DH: Alternative organization for medical practice. Legal Aspects of Medical Practice. October, 1983: 2-5.

11. Cowan DH and Bertsch E: Innovative Therapy: The Responsibility of Hospitals. J

Legal Med 219-251, 1984.

12. Cowan DH: Business Considerations Affecting PPO Contracting: The PPO Perspective. In: Physicians and Attorneys Look at Preferred Provider Organizations. National Health Lawyers Association, Washington, DC, 1984.

13. Cowan DH: Innovative Therapy v. Experimentation. 21(4) Tort & Insurance Law

Journal, 619-633, Summer, 1986.

14. Cowan DH: Medical Staff Legal Issues. 17(4) Toledo Law Review, 851-865, 1986.

15. Cowan DH: The Regulation of Novel Medical Practices. Part I 2(10) Ohio Health Law Insider, 1-6, Part II 2(11) Ohio Law Insider, 1-6, 1988.

16. Cowan DH: PHO’s Represent an Attractive Compromise For Many Physicians.

3(1) The PHO-IHO Report. January, 1995.

BOOKS 1. Cowan DH: Preferred Providers Organizations: Planning, Organization and

Operation. Aspen Systems Corporation. Rockville, Maryland. July, 1984. 2. Cowan DH, Kantorowitz J, Moskowitz J, and Rheinstein, P: Proceedings of

Conference on Legal and Ethical Issues Surrounding Organ Transplantation. Health Administration Press. Ann Arbor, MI, 1987.

BOOK CHAPTERS 1. Cowan DH: Health Maintenance Organizations and Preferred Provider

Organizations. In Hospital Management: Winning Strategies for the 80’s.

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Edited by J. Pena and V.A. Glesnes-Anderson. Aspen Systems Corporation. Rockville, Maryland. December, 1984.

2. Cowan DH: Regulation of Medical Practice. In Proceedings of Conference on

Legal and Ethical Issues Surrounding Organ Transplantation. Edited by Cowan, D.H., Kantrowitz, J., Moskowith, J., and Rheinstein, P. Health Administration Press. Ann Arbor, MI., 1987.

3. “Physician and Patient” in Volume 3, Chapter 32, pps 89-124. Couse’s Ohio Form

Book. Glen Weissenberger, Editor in Chief. Anderson Publishing Co., Cincinnati, Ohio. 1985

4. Cowan DH: “Alternative Health Care Delivery Systems: Health Maintenance

Organizations and Preferred Provider Organizations” In Legal Medicine 1986. Edited by Cyril H. Wecht, M.D., J.D. Appleton Century Crofts, New York, NY.

5. Cowan DH: Contracts Between Physicians and Hospitals. In: Physician Managers

and the Law: Employment and Personal Service Contracts. American Academy of Medical Directors. Tampa, FL, 1987.

6. Cowan, DH: Physician Contracting with Preferred Provider Organizations. In:

Physician Managers and the Law: Employment and Personal Service Contracts. American Academy of Medical Directors. Tampa, FL, 1987.

7. Goheen JC and Cowan DH: “Business and Financial Aspects of Medical

Practice.” In Legal Medicine: Legal Dynamics of Medical Encounters. The American College of Legal Medicine. C.V. Mosby Co., St. Louis, MO, 1988.

8. Cowan DH: “Issues in the Review of Clinical Drug Trials by IRB’s.” In Clinical

Drug Trials and Tribulations. Edited by Cato, A. Marcel Dekker, New York. 1988.

9. Cowan DH: “The Structure and Function of the Medical Staff: The Medical Staff

and Quality Assurance.” In Legal Aspects of Medical Quality Management. The American College of Physician Executives. Tampa, FL 1989.

10. Cowan DH: “Contracts Between Physicians and Hospitals.” In Physician’s

Survival Guide. Legal Pitfalls and Solutions. American Medical Association and National Health Lawyers Association. Chicago, IL and Washington, DC, 1991.

11. Cowan, DH: “Issues in the Review of Clinical Drug Trials by IRBs.” In: Clinical

Drug Trials and Tribulations. Second Edition, Revised and Expanded. Edited by Cato A and Sutton L. Marcel Dekker, New York. 2002.

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BOOK REVIEWS

1. Cowan, DH: Review of Health Care at the Abyss: Managed Care vs. The Goals of Medicine, by Williams, ED and Vander Reis L, The Journal of Ethics, Law and Aging, Vol 4, pp 121-126, 1998.

ABSTRACTS (* Denotes paper presented)

*1. Libre EP, Cowan, DH and Shulman, NR: Influence of spleen and platelets on factor VIII levels. Blood 26:850-51, 1965.

*2. Watkins SP Jr, Cowan DH and Shulman NR: Differentiation of immunologic forms

of idiopathic thrombocytopenic purpura. J Clinc Invest 46:1129, 1967.

*3. Cowan DH: Thrombokinetics in alcoholism. J Lab Clin Med 74:865, 1969. *4. Cowan DH: Effect of alcohol on circulating platelets. Blood 34:850, 1969. 5. Cowan DH and Stjernholm RL: Changes in human platelet metabolism with

alcohol ingestion. Clin Res 18:401, 1970.

6. Cowan DH and Stjernholm RL: Effect of alcohol ingestion on carbohydrate metabolism in human platelets. Abstract #257 in Proceedings on the 13th Annual Meeting of the American Society of Hematology. San Juan, Puerto Rico. December 6-8, 1970.

7. Haut MJ and Cowan DH: Effect of ethanol on human platelet function. J Clin

Invest 50:44a, 1971.

8. Cowan DH and Haut MJ: Qualitative platelet abnormalities in leukemia. Blood 38:816, 1971.

9. Haut MJ and Cowan DH: Ethanol-induced abnormalities of platelet function.

Abstract #252 in Proceedings of the 14th Annual Meeting of the American Society of Hematology. San Francisco, CA December 5-7, 1971.

10. Cowan DH: Thrombokinetic studies in acute leukemia. Abstract #69 in

Proceeding of the 64th Annual Meeting of the American Society for Clinical Investigation. Atlantic City, New Jersey. May 1, 1972, page 22a.

11. Haut MJ, Cowan, DH and Harria JW: Platelet Survival and function in sickle cell

anemia. Clin Res 20:489, 1972.

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*12. Cowan DH and Marsick SM: Platelet adenine Nucleotide metabolism in acute

leukemia. Presented at the Annual Meeting of the Central Society for Clinical Research. November 3, 1973. Clin Res 21:871, 1973.

13. Cowan DH, Marsick SM and Kolesar JD: Mechanism of platelet dysfunction in

acute leukemia. Abstract #57 in the Proceedings of the16th Annual Meeting of the American Society of Hematology. Chicago, Illinois December 3, 1973.

14. Cowan DH, Shook, P and Graham RC: Effect of acidified anticoagulants on

platelet behavior. Abstract #301 in the Proceedings of the 16th Annual Meeting of the American Society of Hematology. Chicago, Illinois December 1-4, 1973.

*15. Cowan DH, Bowman, LS, Fratianne, RB and Ahmed F: Changes in platelet

function and clotting in patients with severe thermal injury. Abstract #60 in the Proceedings of the 6th Annual Meting of the American Burn Association. Cincinnati, Ohio. April 5-6, 1974.

*16. Cowan DH, Shook PL and Graham RC, Jr.: Hyperosmolality, effect on platelet

function and ultrastructure. In the Proceedings of the XV Congress of the International Society of Hematology. Jerusalem, Israel September 1-6, 1974. Page 200.

17. Cowan DH, Shook PJ and Graham RC, Jr.: Hyperosmolality, effect on platelet

function and ultrastructure. Clin Res 22:38A, 1974.

18. Cowan DH, Giroski P: Alteration of platelet adherence to collagen by aspirin. Abstract #460 in the Proceedings of the 2nd National Conference on Thrombosis and Hemostasis, 49th scientific Session of the American Heart Association. Dallas, Texas. October 16, 1976. Circulation 54(4) Suppl II:17, 1976.

19. Cowan DH and Baunach DC: Cyclic AMP and ethanol: observations in human

blood platelets. Clin Res 24:570A, 1976.

20. Cowan DH and Baunach DC: Platelet cyclic AMP reduction in alcohol- related thrombocytopathia. Abstract #434 in the Proceedings of the 19th Annual Meeting of the American Society of Hematology. Boston, Massachusetts. December 4-6, 1976. Page 198.

21. Cowan DH and Shook P: Effects of ethanol on platelet serotonin

metabolism. Abstract #435 in the Proceedings of the 19th Annual Meeting of the American Society of Hematology. Boston, Massachusetts. December 4-7, 1976. Page 198.

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22. Cowan DH and Shook P: Effects of ethanol on platelet serotonin

metabolism. VI International Congress on Thrombosis and Hemostasis. Philadelphia, Pennsylvania. June 27, 1977. Thromb Haemost 38:33, 1977.

*23. Cowan DH, Kikta M and Baunach D: Alteration of platelet cyclic AMP

(CAMP) by ethanol. VI International Congress on Thrombosis and Haemostasis. Philadelphia, Pennsylvania. June 27, 1977. Thromb Haemost 38:270, 1977.

*24. Cowan, DH, Robertson, AL Jr., Giroski P and Shook P: The effect of inhibition of

prostaglandin synthesis on human platelet-collagen interaction. In the Proceedings of the 6th International Symposium on Drugs Affecting Lipid Metabolism. Philadelphia, Pennsylvania. August 29, 1977, Page 16.

*25. Cowan DH: The role of thrombin and fibrin formation in platelet-collagen

interaction. Presented at the 53rd Annual Meeting of the Central Society for Clinical Research. Chicago, Illinois. November 6, 1980. Clin Res 28:767a, 1980.

*26. Cowan DH and Graham J: Effect of platelet lysate on growth of human tumors

colonies. Clin Res 28:76A, 1980. *27. Cowan DH: Ethical issues attending recruiting subjects for clinical trials of

adjuvant therapy. Presented at the 3rd International Conference on the Adjuvant Therapy of Cancer. Tucson, Arizona. March 18-21, 1981.

*28. Cowan DH and Graham J: Effect of platelet-derived factors on human colony

growth. Presented at the 72nd Annual Meeting of the American Association for Cancer Research. Washington, DC, April 29, 1981.

*29. Cowan DH and Graham J: Effect of platelet lysate on growth of human tumor

colonies. Presented at the Chesapeake Conference on Hemostasis and Malignancy. Interaction of Platelets and Tumor Cells. St. Mary’s, Maryland. June 26-30, 1981.

*30. Cowan DH: Stimulation of human tumor colony formation by platelet-derived

growth factor(s) PDGF. Presented at the Third Conference on Human Tumor Cloning. Tucson, Arizona. January 10-12, 1982.

*31. Cowan DH, Paskevich MC and Quinn PG: Characteristics of a platelet-derived

growth factor (PDGF) that stimulates human tumor colony formation. Presented at the 73rd Annual Meeting of the American Association for Cancer Research. St. Louis, Missouri. April 28, 1982.

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*32. Cowan DH, Graham J, Paskevich MC and Quinn PG: Effect of platelet-derived growth factor (PDGF) on colony formation of human breast cancer cells. Presented at the 5th Annual Conference on Breast Cancer. San Antonio, Texas. November 5, 1982.

*33. Cowan DH and McGinnis B: Influence of arachidonic acid on platelet

adherence of collagen. American Society of Hematology. Blood *34. Quinn PG, Paskevich MC and Cowan DH: Enhanced plating efficiency of human

tumors in soft agar using 15mm culture wells: effect on chemosensitivity testing. Abstract #25. Presented at the International Conference on Predictive Drug Testing on Human Tumor Cells. Zurich, Switzerland. July 20-22, 1983. May, 1994.

Documents

CURRICULUM VITAE Dale H. Cowan, MD, JD, FACP ADDRESS: Cancer